UBE2CP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.67491774
2regulation of cilium movement (GO:0003352)4.96394858
3ovulation cycle (GO:0042698)4.67644014
4regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.58522695
5pericardium development (GO:0060039)4.45334176
6muscle cell cellular homeostasis (GO:0046716)4.30551047
7photoreceptor cell maintenance (GO:0045494)4.10047698
8protein K11-linked deubiquitination (GO:0035871)3.86536421
9artery smooth muscle contraction (GO:0014824)3.84321694
10regulation of sarcomere organization (GO:0060297)3.77904541
11peptidyl-histidine modification (GO:0018202)3.77613327
12N-terminal protein amino acid acetylation (GO:0006474)3.72350042
13tonic smooth muscle contraction (GO:0014820)3.62909700
14regulation of telomere maintenance (GO:0032204)3.62623006
15negative regulation of nitric-oxide synthase activity (GO:0051001)3.59955448
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.55402451
17replication fork processing (GO:0031297)3.54020937
18positive regulation of mitochondrial fission (GO:0090141)3.53830187
19DNA deamination (GO:0045006)3.52691951
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.49191088
21reciprocal meiotic recombination (GO:0007131)3.42688007
22reciprocal DNA recombination (GO:0035825)3.42688007
23negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.41505562
24regulation of protein glycosylation (GO:0060049)3.36550746
25multicellular organismal movement (GO:0050879)3.33572022
26musculoskeletal movement (GO:0050881)3.33572022
27histone H2A acetylation (GO:0043968)3.32581635
28branched-chain amino acid catabolic process (GO:0009083)3.27545969
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.27004565
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25910182
31vascular smooth muscle contraction (GO:0014829)3.24238832
32protein localization to cilium (GO:0061512)3.23892824
33intraciliary transport (GO:0042073)3.23365797
34positive regulation of chemokine secretion (GO:0090197)3.23332004
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.16005536
36lysine catabolic process (GO:0006554)3.13896059
37lysine metabolic process (GO:0006553)3.13896059
38alkaloid metabolic process (GO:0009820)3.13083168
39cellular response to leptin stimulus (GO:0044320)3.11000373
40response to folic acid (GO:0051593)3.08155509
41brain morphogenesis (GO:0048854)3.07843530
42regulation of acyl-CoA biosynthetic process (GO:0050812)3.07148319
43regulation of sulfur metabolic process (GO:0042762)3.03132540
44establishment of protein localization to Golgi (GO:0072600)2.98544121
45regulation of integrin-mediated signaling pathway (GO:2001044)2.95856486
46multicellular organism reproduction (GO:0032504)2.94657544
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.94253480
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.94253480
49regulation of translation, ncRNA-mediated (GO:0045974)2.94253480
50establishment of protein localization to mitochondrial membrane (GO:0090151)2.92104810
51regulation of chemokine secretion (GO:0090196)2.88828684
52telomere maintenance via telomerase (GO:0007004)2.87228272
53spindle checkpoint (GO:0031577)2.85664080
54histone mRNA catabolic process (GO:0071044)2.83881640
55striated muscle atrophy (GO:0014891)2.83560627
56microtubule nucleation (GO:0007020)2.81682331
57negative regulation of DNA recombination (GO:0045910)2.80242770
58organelle disassembly (GO:1903008)2.77903362
59membrane raft organization (GO:0031579)2.77834817
60regulation of relaxation of muscle (GO:1901077)2.77146332
61dendritic spine morphogenesis (GO:0060997)2.76163871
62muscle atrophy (GO:0014889)2.75498462
63retinal ganglion cell axon guidance (GO:0031290)2.72467376
64protein heterotetramerization (GO:0051290)2.71800391
65cullin deneddylation (GO:0010388)2.71040432
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69082238
67regulation of mitochondrial fission (GO:0090140)2.68601413
68neuronal action potential (GO:0019228)2.65035292
69glyoxylate metabolic process (GO:0046487)2.65020166
70negative regulation of response to food (GO:0032096)2.63778186
71negative regulation of appetite (GO:0032099)2.63778186
72myelin assembly (GO:0032288)2.63755745
73synaptic transmission, cholinergic (GO:0007271)2.62156201
74positive regulation of interleukin-8 secretion (GO:2000484)2.61645606
75ribonucleoprotein complex disassembly (GO:0032988)2.61389213
76mitotic spindle checkpoint (GO:0071174)2.61368762
77regulation of coenzyme metabolic process (GO:0051196)2.60797613
78regulation of cofactor metabolic process (GO:0051193)2.60797613
79microtubule anchoring (GO:0034453)2.58295114
80cilium morphogenesis (GO:0060271)2.56165179
81nucleus localization (GO:0051647)2.54596095
82striatum development (GO:0021756)2.54553613
83nonmotile primary cilium assembly (GO:0035058)2.53938587
84galactose catabolic process (GO:0019388)2.52921190
85signal peptide processing (GO:0006465)2.52624731
86cellular response to dsRNA (GO:0071359)2.51700826
87mitotic spindle assembly checkpoint (GO:0007094)2.51354251
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.50327755
89response to X-ray (GO:0010165)2.49813163
90branched-chain amino acid metabolic process (GO:0009081)2.46789950
91spindle assembly checkpoint (GO:0071173)2.46442681
92ventricular cardiac muscle cell development (GO:0055015)2.44798905
93negative regulation of protein localization to cell surface (GO:2000009)2.44571223
94RNA-dependent DNA replication (GO:0006278)2.44363943
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.43666969
96regulation of mitotic spindle checkpoint (GO:1903504)2.43666969
97protein-chromophore linkage (GO:0018298)2.41855990
98heart contraction (GO:0060047)2.41829019
99heart process (GO:0003015)2.41829019
100double-strand break repair via homologous recombination (GO:0000724)2.41613293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.42963747
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.37468471
3IGF1R_20145208_ChIP-Seq_DFB_Human3.13592335
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82421520
5ZNF274_21170338_ChIP-Seq_K562_Hela2.78576004
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69884516
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65769845
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.59303711
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51606357
10GBX2_23144817_ChIP-Seq_PC3_Human2.45486882
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.33118127
12FUS_26573619_Chip-Seq_HEK293_Human2.29110549
13EWS_26573619_Chip-Seq_HEK293_Human2.28754557
14TAF15_26573619_Chip-Seq_HEK293_Human2.20853463
15ER_23166858_ChIP-Seq_MCF-7_Human2.05032199
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93910855
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92935072
18SMAD4_21799915_ChIP-Seq_A2780_Human1.91865851
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88206921
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87463665
21P300_19829295_ChIP-Seq_ESCs_Human1.86592757
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85924706
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.85606839
24ELK1_19687146_ChIP-ChIP_HELA_Human1.85493532
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.82303565
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81624217
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80552578
28VDR_22108803_ChIP-Seq_LS180_Human1.78527854
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77495533
30STAT3_23295773_ChIP-Seq_U87_Human1.76578442
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76341132
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.76121402
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73747094
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.73363718
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71330317
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70403780
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70214480
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65713465
39CBP_20019798_ChIP-Seq_JUKART_Human1.65713465
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59565314
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56450376
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54853732
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.50923865
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49378073
45TCF4_23295773_ChIP-Seq_U87_Human1.48689457
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48437143
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48323328
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47658505
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46866145
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45981450
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45476837
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45092966
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44414704
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42754799
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41823328
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41318109
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.38184878
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35804901
59BCAT_22108803_ChIP-Seq_LS180_Human1.35124074
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.34832204
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.34452477
62TP53_16413492_ChIP-PET_HCT116_Human1.32510234
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32402037
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.31485771
65AR_25329375_ChIP-Seq_VCAP_Human1.28442999
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27379922
67SALL4_22934838_ChIP-ChIP_CD34+_Human1.26950876
68CJUN_26792858_Chip-Seq_BT549_Human1.26511539
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25814027
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25674028
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24212317
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24212317
73BRD4_25478319_ChIP-Seq_HGPS_Human1.23546912
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21347298
75P53_22387025_ChIP-Seq_ESCs_Mouse1.20511644
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16456578
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15887096
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13092896
79TCF4_22108803_ChIP-Seq_LS180_Human1.12602515
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11621757
81RUNX2_22187159_ChIP-Seq_PCA_Human1.09849354
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09531113
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.09498227
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.07452974
85VDR_23849224_ChIP-Seq_CD4+_Human1.06911507
86CDX2_22108803_ChIP-Seq_LS180_Human1.06825684
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06537890
88KDM2B_26808549_Chip-Seq_REH_Human1.05195229
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05042812
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.04328271
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03439929
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03370664
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02888880
94P300_18555785_Chip-Seq_ESCs_Mouse1.02107590
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00074792
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99828388
97OCT4_18555785_Chip-Seq_ESCs_Mouse0.99507615
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98535332
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98535332
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.98162585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.12503775
2MP0006054_spinal_hemorrhage4.61027691
3MP0000569_abnormal_digit_pigmentation3.78348533
4MP0008058_abnormal_DNA_repair2.94045800
5MP0000749_muscle_degeneration2.35672413
6MP0004084_abnormal_cardiac_muscle2.31736985
7MP0004215_abnormal_myocardial_fiber2.29406649
8MP0001986_abnormal_taste_sensitivity2.19934232
9MP0001984_abnormal_olfaction2.11251591
10MP0005084_abnormal_gallbladder_morpholo1.96641910
11MP0005253_abnormal_eye_physiology1.95752963
12MP0003195_calcinosis1.86591675
13MP0003011_delayed_dark_adaptation1.83486390
14MP0005220_abnormal_exocrine_pancreas1.82535723
15MP0000372_irregular_coat_pigmentation1.73963472
16MP0009697_abnormal_copulation1.73949938
17MP0002102_abnormal_ear_morphology1.70990404
18MP0002736_abnormal_nociception_after1.70415552
19MP0002160_abnormal_reproductive_system1.68159641
20MP0004133_heterotaxia1.63892819
21MP0008260_abnormal_autophagy1.63812921
22MP0002168_other_aberrant_phenotype1.62888147
23MP0005310_abnormal_salivary_gland1.61852550
24MP0001764_abnormal_homeostasis1.59365775
25MP0000427_abnormal_hair_cycle1.53506135
26MP0005551_abnormal_eye_electrophysiolog1.52586824
27MP0004883_abnormal_blood_vessel1.52012088
28MP0004145_abnormal_muscle_electrophysio1.51196449
29MP0003943_abnormal_hepatobiliary_system1.51013788
30MP0000538_abnormal_urinary_bladder1.45468927
31MP0004036_abnormal_muscle_relaxation1.42633935
32MP0008057_abnormal_DNA_replication1.37315950
33MP0008007_abnormal_cellular_replicative1.36635940
34MP0005395_other_phenotype1.33625111
35MP0000516_abnormal_urinary_system1.33023813
36MP0005367_renal/urinary_system_phenotyp1.33023813
37MP0001661_extended_life_span1.31922273
38MP0003172_abnormal_lysosome_physiology1.30125770
39MP0001853_heart_inflammation1.28671886
40MP0005360_urolithiasis1.28436175
41MP0003045_fibrosis1.25825700
42MP0010094_abnormal_chromosome_stability1.23214506
43MP0002928_abnormal_bile_duct1.21699534
44MP0000383_abnormal_hair_follicle1.19094687
45MP0005391_vision/eye_phenotype1.15500654
46MP0006072_abnormal_retinal_apoptosis1.14487455
47MP0009384_cardiac_valve_regurgitation1.14120724
48MP0003077_abnormal_cell_cycle1.11275988
49MP0001293_anophthalmia1.10970390
50MP0001968_abnormal_touch/_nociception1.10383864
51MP0001286_abnormal_eye_development1.06555663
52MP0010307_abnormal_tumor_latency1.05737903
53MP0003183_abnormal_peptide_metabolism1.05538489
54MP0004272_abnormal_basement_membrane1.04364752
55MP0002254_reproductive_system_inflammat1.04161459
56MP0002751_abnormal_autonomic_nervous1.03919355
57MP0005195_abnormal_posterior_eye1.03371840
58MP0001486_abnormal_startle_reflex1.02939347
59MP0003283_abnormal_digestive_organ1.02312034
60MP0005389_reproductive_system_phenotype1.01671072
61MP0010678_abnormal_skin_adnexa1.01411768
62MP0003718_maternal_effect1.01363685
63MP0000230_abnormal_systemic_arterial1.00872618
64MP0001177_atelectasis1.00406251
65MP0000647_abnormal_sebaceous_gland0.99471283
66MP0005595_abnormal_vascular_smooth0.99083392
67MP0005410_abnormal_fertilization0.98262801
68MP0002127_abnormal_cardiovascular_syste0.97527596
69MP0002396_abnormal_hematopoietic_system0.96935553
70MP0005171_absent_coat_pigmentation0.96554511
71MP0003121_genomic_imprinting0.96472369
72MP0002108_abnormal_muscle_morphology0.96346997
73MP0003111_abnormal_nucleus_morphology0.95296617
74MP0001119_abnormal_female_reproductive0.93176023
75MP0000358_abnormal_cell_content/0.92788233
76MP0002933_joint_inflammation0.90485350
77MP0003787_abnormal_imprinting0.90431046
78MP0002233_abnormal_nose_morphology0.89997551
79MP0004808_abnormal_hematopoietic_stem0.87319615
80MP0005275_abnormal_skin_tensile0.86799782
81MP0001299_abnormal_eye_distance/0.85835131
82MP0000015_abnormal_ear_pigmentation0.84871850
83MP0005408_hypopigmentation0.84597120
84MP0003786_premature_aging0.84278511
85MP0002095_abnormal_skin_pigmentation0.83460565
86MP0003828_pulmonary_edema0.83044339
87MP0005174_abnormal_tail_pigmentation0.82428228
88MP0006276_abnormal_autonomic_nervous0.82340362
89MP0005164_abnormal_response_to0.79645566
90MP0008789_abnormal_olfactory_epithelium0.79327592
91MP0003937_abnormal_limbs/digits/tail_de0.78298582
92MP0001324_abnormal_eye_pigmentation0.77880634
93MP0000428_abnormal_craniofacial_morphol0.77228014
94MP0001756_abnormal_urination0.76926088
95MP0001929_abnormal_gametogenesis0.76507509
96MP0002332_abnormal_exercise_endurance0.72082474
97MP0002109_abnormal_limb_morphology0.68570190
98MP0003890_abnormal_embryonic-extraembry0.68151151
99MP0005620_abnormal_muscle_contractility0.68095858
100MP0002282_abnormal_trachea_morphology0.67827546

Predicted human phenotypes

RankGene SetZ-score
1Popliteal pterygium (HP:0009756)6.49960172
2Type 2 muscle fiber atrophy (HP:0003554)5.11003629
3Amniotic constriction ring (HP:0009775)4.53970519
4Abnormality of placental membranes (HP:0011409)4.53970519
5Muscle fiber atrophy (HP:0100295)4.15239953
6Congenital primary aphakia (HP:0007707)3.69233376
7Gait imbalance (HP:0002141)3.47318366
8Aplasia of the musculature (HP:0100854)3.31202253
9Supernumerary spleens (HP:0009799)3.29764510
10Dyschromatopsia (HP:0007641)3.26379174
11Cystic hygroma (HP:0000476)3.26271442
12Medial flaring of the eyebrow (HP:0010747)3.25889094
13Aplasia/Hypoplasia of the tongue (HP:0010295)3.21981218
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.16292432
15Absent/shortened dynein arms (HP:0200106)3.16292432
16Nephrogenic diabetes insipidus (HP:0009806)3.14402674
17Pancreatic fibrosis (HP:0100732)3.10827488
18Pterygium (HP:0001059)3.09014240
19Volvulus (HP:0002580)2.97613032
20Genital tract atresia (HP:0001827)2.94605536
21Nephronophthisis (HP:0000090)2.92987708
22Postaxial foot polydactyly (HP:0001830)2.87391555
23Poor coordination (HP:0002370)2.85335477
24Weak cry (HP:0001612)2.84566310
25Abnormality of the neuromuscular junction (HP:0003398)2.81602015
26Fatigable weakness (HP:0003473)2.81602015
27Fetal akinesia sequence (HP:0001989)2.79058962
28True hermaphroditism (HP:0010459)2.76148227
29Vaginal atresia (HP:0000148)2.73676665
30Tubulointerstitial nephritis (HP:0001970)2.71506546
31Chronic hepatic failure (HP:0100626)2.67586427
32Metaphyseal dysplasia (HP:0100255)2.65018396
33Pancreatic cysts (HP:0001737)2.62360748
34Malignant hyperthermia (HP:0002047)2.56496566
35Microglossia (HP:0000171)2.54705966
36Gowers sign (HP:0003391)2.53945160
37Long clavicles (HP:0000890)2.52106189
38Abnormality of the renal medulla (HP:0100957)2.47897261
39Abnormality of midbrain morphology (HP:0002418)2.46571766
40Molar tooth sign on MRI (HP:0002419)2.46571766
41Bifid tongue (HP:0010297)2.43237475
42Hyperventilation (HP:0002883)2.41651784
43Mesomelia (HP:0003027)2.39231112
44Hyperglycinemia (HP:0002154)2.36765445
45Atonic seizures (HP:0010819)2.35387778
46Chin dimple (HP:0010751)2.33835595
47Akinesia (HP:0002304)2.29513938
48Gaze-evoked nystagmus (HP:0000640)2.29043919
49Hypoplastic iliac wings (HP:0002866)2.23619971
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.22996941
51Aplasia/Hypoplasia of the lens (HP:0008063)2.21814315
52Pancreatic islet-cell hyperplasia (HP:0004510)2.20274310
53Left ventricular hypertrophy (HP:0001712)2.18473387
54Cone-rod dystrophy (HP:0000548)2.15406914
55Postaxial hand polydactyly (HP:0001162)2.13544650
56Calf muscle hypertrophy (HP:0008981)2.13351210
57Abnormality of the parathyroid morphology (HP:0011766)2.08289568
58Renal cortical cysts (HP:0000803)2.06051218
59Hypoplastic pelvis (HP:0008839)2.05668934
60Specific learning disability (HP:0001328)2.04377132
61Abnormality of the wing of the ilium (HP:0011867)2.04341518
62Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.02337279
63Anencephaly (HP:0002323)2.01479760
64Spinal muscular atrophy (HP:0007269)2.01317265
65Cystic liver disease (HP:0006706)2.01180771
66Intestinal atresia (HP:0011100)2.01176989
67Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.99558239
68Broad foot (HP:0001769)1.93527876
69Decreased muscle mass (HP:0003199)1.93265312
70Abnormality of the epiphyses of the hand (HP:0005924)1.92557818
71Decreased testicular size (HP:0008734)1.92524925
72Thin ribs (HP:0000883)1.91596293
73Depressed nasal tip (HP:0000437)1.91550358
74Astigmatism (HP:0000483)1.91482258
75Short thorax (HP:0010306)1.90077668
76Hypoplastic labia majora (HP:0000059)1.89745888
77Reduced subcutaneous adipose tissue (HP:0003758)1.88836823
78Gastrointestinal atresia (HP:0002589)1.88070388
79Embryonal renal neoplasm (HP:0011794)1.86573517
80Decreased lacrimation (HP:0000633)1.86302062
81Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85979015
82Fatigue (HP:0012378)1.84021393
83Nephroblastoma (Wilms tumor) (HP:0002667)1.83601909
84Long toe (HP:0010511)1.79984481
85Thyroid carcinoma (HP:0002890)1.78810227
86Retinitis pigmentosa (HP:0000510)1.77768063
87Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77144845
88Abnormality of the labia majora (HP:0012881)1.76677897
89Abnormality of the ischium (HP:0003174)1.76633920
90Papillary thyroid carcinoma (HP:0002895)1.75014999
91Bile duct proliferation (HP:0001408)1.74620562
92Abnormal biliary tract physiology (HP:0012439)1.74620562
93Muscle hypertrophy of the lower extremities (HP:0008968)1.74456651
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73540325
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.73540325
96Abnormality of the corticospinal tract (HP:0002492)1.72197379
97Easy fatigability (HP:0003388)1.71517564
98Spastic diplegia (HP:0001264)1.71482156
99Sensory axonal neuropathy (HP:0003390)1.68236701
100Abnormal ciliary motility (HP:0012262)1.67680573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.12564362
2BMPR1B3.67988313
3ACVR1B3.34536769
4EIF2AK33.09353508
5TNIK2.86074508
6CCNB12.60308111
7PNCK2.44439954
8NUAK12.24653321
9AKT32.18182541
10MELK2.07871865
11MKNK22.05987525
12PBK1.98891213
13PLK41.96868029
14CDK81.92259778
15EPHB11.81810271
16SGK21.68987110
17BCKDK1.64754422
18PLK31.62030288
19TGFBR11.59483541
20TSSK61.58824249
21NLK1.57438894
22PLK21.54236502
23ZAK1.47578810
24WNK31.46811550
25ERBB31.45236010
26PKN21.42826764
27FLT31.34181699
28MAPK131.30664931
29BRSK21.30511007
30MKNK11.27678739
31GRK11.21438864
32TNK21.20570934
33FGFR21.19364451
34TAOK31.18808830
35INSRR1.11420327
36MAPK111.11164538
37PIK3CA1.05960693
38NEK91.04260870
39SGK4940.99982464
40SGK2230.99982464
41STK40.99364462
42WEE10.95230604
43PAK30.94635873
44BRD40.93124133
45FES0.92226473
46TEC0.90453184
47DMPK0.86160317
48MAP3K120.83819890
49PLK10.83560542
50PRKD30.82317313
51BRSK10.80866295
52FGFR10.80295988
53IKBKE0.80205598
54WNK10.80096628
55TRPM70.78524505
56CAMK1G0.76875231
57FER0.75639660
58NEK60.75433285
59MAP3K50.73201590
60SGK30.72238913
61MAP4K20.71973208
62BMPR20.71515165
63MUSK0.63159664
64CDK90.62418571
65DYRK1A0.62058943
66VRK10.59695731
67AURKB0.58175437
68ATM0.58159201
69CHEK10.57827921
70EIF2AK10.57365402
71PRKCE0.56820613
72STK390.54301100
73LATS10.50719208
74MYLK0.50503097
75PIM10.50022658
76TRIM280.49157205
77ROCK10.45854073
78CDK190.45335538
79TTK0.44659921
80CAMK1D0.43489842
81RAF10.43280128
82ABL10.42241166
83PIK3CG0.41526084
84OXSR10.41033435
85PRKCQ0.40919679
86CHEK20.39012896
87MARK30.37535310
88TGFBR20.37194803
89NEK10.36491359
90HCK0.35733224
91INSR0.35665434
92WNK40.35293584
93SGK10.34315693
94STK30.33082184
95CLK10.32512755
96IGF1R0.31974104
97ATR0.31965358
98PRKACB0.31574430
99CHUK0.31545975
100FGFR30.29889644

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.42449727
2Propanoate metabolism_Homo sapiens_hsa006403.12446024
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.99481760
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97748721
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86002274
6Homologous recombination_Homo sapiens_hsa034402.68757535
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65113776
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61098246
9Protein export_Homo sapiens_hsa030602.57798254
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11290476
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89727154
12Steroid biosynthesis_Homo sapiens_hsa001001.89664090
13Selenocompound metabolism_Homo sapiens_hsa004501.76165804
14Lysine degradation_Homo sapiens_hsa003101.75469492
15Fanconi anemia pathway_Homo sapiens_hsa034601.74425951
16Circadian rhythm_Homo sapiens_hsa047101.71146822
17RNA degradation_Homo sapiens_hsa030181.64432863
18Nitrogen metabolism_Homo sapiens_hsa009101.57993054
19Basal transcription factors_Homo sapiens_hsa030221.53689797
20Pyruvate metabolism_Homo sapiens_hsa006201.51852469
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51091810
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50370338
23One carbon pool by folate_Homo sapiens_hsa006701.47657160
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47420059
25Fatty acid elongation_Homo sapiens_hsa000621.46838189
26Taste transduction_Homo sapiens_hsa047421.45889069
27Butanoate metabolism_Homo sapiens_hsa006501.40951349
28Peroxisome_Homo sapiens_hsa041461.40873895
29Regulation of autophagy_Homo sapiens_hsa041401.38673696
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38414421
31RNA polymerase_Homo sapiens_hsa030201.31800327
32Cell cycle_Homo sapiens_hsa041101.31124170
33Fatty acid metabolism_Homo sapiens_hsa012121.30369767
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29731903
35beta-Alanine metabolism_Homo sapiens_hsa004101.28719407
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27681625
37RNA transport_Homo sapiens_hsa030131.24274135
38p53 signaling pathway_Homo sapiens_hsa041151.16249120
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14183141
40Arginine and proline metabolism_Homo sapiens_hsa003301.12554394
41TGF-beta signaling pathway_Homo sapiens_hsa043501.11881395
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09146265
43Proteasome_Homo sapiens_hsa030501.08247965
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.06584730
45Linoleic acid metabolism_Homo sapiens_hsa005911.06064332
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05544288
47Legionellosis_Homo sapiens_hsa051341.04988210
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98985991
49Hedgehog signaling pathway_Homo sapiens_hsa043400.98933073
50Adherens junction_Homo sapiens_hsa045200.96156667
51Purine metabolism_Homo sapiens_hsa002300.94572997
52Tryptophan metabolism_Homo sapiens_hsa003800.94228084
53Sulfur metabolism_Homo sapiens_hsa009200.91006665
54Systemic lupus erythematosus_Homo sapiens_hsa053220.89327606
55Base excision repair_Homo sapiens_hsa034100.87962261
56Mismatch repair_Homo sapiens_hsa034300.86867118
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.83678223
58Arachidonic acid metabolism_Homo sapiens_hsa005900.81471434
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78932165
60Nucleotide excision repair_Homo sapiens_hsa034200.77746817
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70945427
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69021505
63Fatty acid degradation_Homo sapiens_hsa000710.68638955
64Fatty acid biosynthesis_Homo sapiens_hsa000610.66120837
65Colorectal cancer_Homo sapiens_hsa052100.65907737
66Histidine metabolism_Homo sapiens_hsa003400.64849821
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64486638
68Glycerolipid metabolism_Homo sapiens_hsa005610.62315856
69Pyrimidine metabolism_Homo sapiens_hsa002400.60540936
70Sulfur relay system_Homo sapiens_hsa041220.58179059
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57204133
72Ether lipid metabolism_Homo sapiens_hsa005650.56838581
73Basal cell carcinoma_Homo sapiens_hsa052170.55149984
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.49917469
75Glutathione metabolism_Homo sapiens_hsa004800.49548125
76Tight junction_Homo sapiens_hsa045300.45136769
77Dilated cardiomyopathy_Homo sapiens_hsa054140.45113889
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43639385
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41745852
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.41511325
81Oocyte meiosis_Homo sapiens_hsa041140.36955253
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36718456
83Retinol metabolism_Homo sapiens_hsa008300.34219710
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.33974414
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33819196
86Alcoholism_Homo sapiens_hsa050340.31705194
87Metabolic pathways_Homo sapiens_hsa011000.29873766
88FoxO signaling pathway_Homo sapiens_hsa040680.28475893
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27262340
90Vitamin digestion and absorption_Homo sapiens_hsa049770.27133946
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26906814
92Proteoglycans in cancer_Homo sapiens_hsa052050.26698572
93Chemical carcinogenesis_Homo sapiens_hsa052040.26570692
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26107303
95Platelet activation_Homo sapiens_hsa046110.21847314
96MicroRNAs in cancer_Homo sapiens_hsa052060.21566920
97Oxytocin signaling pathway_Homo sapiens_hsa049210.19368547
98Dorso-ventral axis formation_Homo sapiens_hsa043200.18933668
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18826612
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17632111

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