UBE2D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.11174025
2axon ensheathment in central nervous system (GO:0032291)5.11174025
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.94762616
4neutrophil activation involved in immune response (GO:0002283)4.84583310
5sarcoplasmic reticulum calcium ion transport (GO:0070296)4.79176593
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.68952202
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.68952202
8modulation by symbiont of host immune response (GO:0052553)4.68952202
9positive regulation by symbiont of host defense response (GO:0052509)4.68952202
10modulation by symbiont of host defense response (GO:0052031)4.68952202
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.68952202
12response to peptidoglycan (GO:0032494)4.63969417
13neutrophil mediated immunity (GO:0002446)4.43326042
14muscle filament sliding (GO:0030049)4.38955907
15actin-myosin filament sliding (GO:0033275)4.38955907
16macrophage activation involved in immune response (GO:0002281)4.31246160
17detection of molecule of bacterial origin (GO:0032490)4.30800756
18negative regulation of interleukin-12 production (GO:0032695)4.29059920
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08569482
20negative regulation of cell killing (GO:0031342)4.08569482
21regulation of cell communication by electrical coupling (GO:0010649)3.97180054
22skeletal muscle contraction (GO:0003009)3.96885256
23microglial cell activation (GO:0001774)3.96865860
24regulation of interleukin-8 biosynthetic process (GO:0045414)3.92290806
25respiratory burst (GO:0045730)3.90961440
26neuronal action potential propagation (GO:0019227)3.90188476
27myeloid leukocyte mediated immunity (GO:0002444)3.88976603
28regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.78333607
29cerebral cortex radially oriented cell migration (GO:0021799)3.77710574
30neutrophil activation (GO:0042119)3.76740353
31regulation of interferon-beta biosynthetic process (GO:0045357)3.75498193
32presynaptic membrane organization (GO:0097090)3.74900563
33synaptic vesicle maturation (GO:0016188)3.66127965
34regulation of skeletal muscle contraction (GO:0014819)3.62655541
35detection of other organism (GO:0098543)3.62286714
36response to pheromone (GO:0019236)3.60441890
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.58553127
38neuron cell-cell adhesion (GO:0007158)3.57022511
39actin-mediated cell contraction (GO:0070252)3.51326262
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.49887671
41granulocyte activation (GO:0036230)3.47675370
42macrophage activation (GO:0042116)3.47482061
43regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.45452418
44positive regulation of gamma-delta T cell activation (GO:0046645)3.42363415
45dendritic spine morphogenesis (GO:0060997)3.42129177
46presynaptic membrane assembly (GO:0097105)3.42098068
47establishment of mitochondrion localization (GO:0051654)3.37243394
48cranial nerve morphogenesis (GO:0021602)3.36860910
49neuron recognition (GO:0008038)3.34939574
50negative regulation of protein localization to cell surface (GO:2000009)3.34211659
51detection of external biotic stimulus (GO:0098581)3.33951640
52leukocyte migration involved in inflammatory response (GO:0002523)3.31622745
53axonal fasciculation (GO:0007413)3.30623361
54regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.29174172
55neuromuscular synaptic transmission (GO:0007274)3.25036511
56response to host immune response (GO:0052572)3.22431097
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.22431097
58postsynaptic membrane organization (GO:0001941)3.21422129
59central nervous system projection neuron axonogenesis (GO:0021952)3.19895108
60neural tube formation (GO:0001841)3.18818896
61positive regulation of interleukin-1 beta secretion (GO:0050718)3.17658775
62cell migration in hindbrain (GO:0021535)3.17587208
63cellular extravasation (GO:0045123)3.14883432
64dendrite morphogenesis (GO:0048813)3.14553912
65sequestering of actin monomers (GO:0042989)3.13556644
66pyrimidine nucleobase catabolic process (GO:0006208)3.13433000
67regulation of synapse structural plasticity (GO:0051823)3.13159736
68layer formation in cerebral cortex (GO:0021819)3.12655361
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12086623
70positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05868014
71detection of biotic stimulus (GO:0009595)3.05379782
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.04083615
73detection of bacterium (GO:0016045)3.01685370
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01110068
75positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.00228535
76mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.00228535
77negative regulation of axon extension (GO:0030517)2.99162959
78positive regulation of mitochondrial fission (GO:0090141)2.98612323
79immunoglobulin mediated immune response (GO:0016064)2.97775022
80response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.97716826
81skeletal muscle fiber development (GO:0048741)2.97458316
82protein localization to synapse (GO:0035418)2.96381239
83negative regulation of axonogenesis (GO:0050771)2.95491851
84regulation of MHC class II biosynthetic process (GO:0045346)2.94704788
85negative regulation of T cell mediated immunity (GO:0002710)2.94153220
86positive regulation of interleukin-1 secretion (GO:0050716)2.92997443
87regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90332443
88skeletal muscle adaptation (GO:0043501)2.89392796
89negative regulation of interleukin-1 beta production (GO:0032691)2.86217927
90negative regulation of NF-kappaB import into nucleus (GO:0042347)2.85548955
91regulation of interferon-alpha production (GO:0032647)2.85489461
92regulation of interleukin-1 beta secretion (GO:0050706)2.84137514
93neuron fate determination (GO:0048664)2.83414503
94synaptic vesicle exocytosis (GO:0016079)2.83111624
95germinal center formation (GO:0002467)2.82980284
96response to inactivity (GO:0014854)2.81606856
97regulation of B cell receptor signaling pathway (GO:0050855)2.79116922
98glutamate secretion (GO:0014047)2.78369644
99negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77936409
100myeloid cell activation involved in immune response (GO:0002275)2.77338273
101actin filament-based movement (GO:0030048)2.77212768
102regulation of collateral sprouting (GO:0048670)2.75708606
103negative regulation of interleukin-1 production (GO:0032692)2.75215882
104purine nucleotide salvage (GO:0032261)2.75160278
105sarcomere organization (GO:0045214)2.74333648
106positive regulation of interferon-alpha production (GO:0032727)2.72146523
107positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71479254
108regulation of mast cell activation (GO:0033003)2.70800023
109production of molecular mediator involved in inflammatory response (GO:0002532)2.70169899
110myelination (GO:0042552)2.69984589
111regulation of synaptic vesicle exocytosis (GO:2000300)2.69757556
112activated T cell proliferation (GO:0050798)2.69408276
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69148026
114ensheathment of neurons (GO:0007272)2.68770716
115axon ensheathment (GO:0008366)2.68770716
116cerebellar granule cell differentiation (GO:0021707)2.68213980
117positive regulation of mast cell activation (GO:0033005)2.68209083
118myofibril assembly (GO:0030239)2.67102636
119leukocyte aggregation (GO:0070486)2.66884412
120regulation of relaxation of muscle (GO:1901077)2.66590190
121locomotory exploration behavior (GO:0035641)2.65097019
122plasma membrane repair (GO:0001778)2.64073265
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61592395
124regulation of glutamate receptor signaling pathway (GO:1900449)2.61418573
125negative regulation of microtubule polymerization (GO:0031115)2.61413678
126positive regulation of interleukin-6 production (GO:0032755)2.61238357
127regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60414838
128response to host (GO:0075136)2.60189860
129response to host defenses (GO:0052200)2.60189860
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60189860
131regulation of NF-kappaB import into nucleus (GO:0042345)2.60005923
132lipopolysaccharide-mediated signaling pathway (GO:0031663)2.59275688
133regulation of glutamate secretion (GO:0014048)2.58978479
134neuronal ion channel clustering (GO:0045161)2.58464625
135ionotropic glutamate receptor signaling pathway (GO:0035235)2.57213028
136striated muscle contraction (GO:0006941)2.56939899
137regulation of dendritic spine morphogenesis (GO:0061001)2.56801858
138negative regulation of neurotransmitter secretion (GO:0046929)2.56724233
139negative regulation of necroptotic process (GO:0060546)2.56457185
140auditory behavior (GO:0031223)2.56452341
141mitochondrion transport along microtubule (GO:0047497)2.56324271
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.56324271
143vocalization behavior (GO:0071625)2.56171315
144regulation of fever generation (GO:0031620)2.55562811
145positive regulation of interferon-beta production (GO:0032728)2.54223355
146positive regulation of interleukin-17 production (GO:0032740)2.53879922
147regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53241891
148myotube cell development (GO:0014904)2.53026810
149regulation of necroptotic process (GO:0060544)2.52539469
150membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52215359
151central nervous system neuron axonogenesis (GO:0021955)2.51956003
152regulation of interleukin-17 production (GO:0032660)2.51613349
153negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.51457188
154synaptic vesicle docking involved in exocytosis (GO:0016081)2.51419068
155positive regulation of synapse assembly (GO:0051965)2.51024388
156interferon-gamma production (GO:0032609)2.50978899
157positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.50159835
158neutrophil chemotaxis (GO:0030593)2.49812735
159negative regulation of neurotransmitter transport (GO:0051589)2.49232542
160regulation of respiratory system process (GO:0044065)2.49146926
161eye photoreceptor cell differentiation (GO:0001754)2.48379318
162photoreceptor cell differentiation (GO:0046530)2.48379318
163regulation of calcium ion transmembrane transport (GO:1903169)2.47869440
164regulation of calcium ion transmembrane transporter activity (GO:1901019)2.47869440
165purine-containing compound salvage (GO:0043101)2.47764963
166cytokine secretion (GO:0050663)2.47630661
167positive regulation of NF-kappaB import into nucleus (GO:0042346)2.47582538
168regulation of synapse assembly (GO:0051963)2.47095913
169B cell mediated immunity (GO:0019724)2.45360685
170myotube differentiation (GO:0014902)2.45314649
171phagosome maturation (GO:0090382)2.44914043
172leukocyte mediated cytotoxicity (GO:0001909)2.44774160
173positive regulation of type 2 immune response (GO:0002830)2.43678667
174adult walking behavior (GO:0007628)2.43324146
175neutrophil migration (GO:1990266)2.43238138
176regulation of interleukin-6 biosynthetic process (GO:0045408)2.42725293
177defense response to protozoan (GO:0042832)2.42481341
178limb bud formation (GO:0060174)2.42265378
179dendritic spine organization (GO:0097061)2.41810217
180regulation of neuronal synaptic plasticity (GO:0048168)2.40941530
181nerve growth factor signaling pathway (GO:0038180)2.39233636
182negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.38922069
183muscle cell cellular homeostasis (GO:0046716)2.37894041
184regulation of extent of cell growth (GO:0061387)2.37086624
185mechanosensory behavior (GO:0007638)2.36403849
186substantia nigra development (GO:0021762)2.36179602
187creatine metabolic process (GO:0006600)2.35842332
188negative regulation of axon extension involved in axon guidance (GO:0048843)2.35560865
189substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.35547210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.10415225
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.78831888
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15348361
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.02302555
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93922881
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83323350
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83323350
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82565396
9GBX2_23144817_ChIP-Seq_PC3_Human2.80628614
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66659408
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61602905
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.50681117
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49374199
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.48021838
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.39665091
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39402621
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37803397
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.31808148
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.29369814
20AR_21572438_ChIP-Seq_LNCaP_Human2.29301327
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25462863
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20445890
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.18537189
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14061815
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02854777
26* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02762085
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.02125492
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01884225
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.98737201
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97837801
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95932444
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.91195574
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90362892
34DROSHA_22980978_ChIP-Seq_HELA_Human1.87354163
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86125259
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81946178
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79779245
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77819493
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.77322761
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75202194
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72198803
42REST_21632747_ChIP-Seq_MESCs_Mouse1.71488099
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69353623
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66828966
45SPI1_23547873_ChIP-Seq_NB4_Human1.64398905
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61847615
47EWS_26573619_Chip-Seq_HEK293_Human1.60206958
48VDR_24787735_ChIP-Seq_THP-1_Human1.58729108
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58314895
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57883452
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56621217
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56404276
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55774296
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54660154
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.53199578
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.51050102
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.50362834
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.49322081
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47550053
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.45802097
61RNF2_27304074_Chip-Seq_NSC_Mouse1.45491473
62ZNF274_21170338_ChIP-Seq_K562_Hela1.44867489
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44714436
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43451313
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38810216
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36944435
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35280290
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.35135774
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35033867
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34795352
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33953716
72EGR1_19032775_ChIP-ChIP_M12_Human1.31044869
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29064378
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28422026
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28080572
76* FLI1_21867929_ChIP-Seq_TH2_Mouse1.27711141
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25352097
78* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24311870
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24275325
80VDR_22108803_ChIP-Seq_LS180_Human1.22660045
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22534433
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.21210991
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.20098745
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19490828
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.19394826
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18377993
87* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17046116
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16836469
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.16720823
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.16546425
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15499399
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14638524
93* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13268345
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.12301978
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12285892
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11761231
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11761231
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11510168
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11207378
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11207378
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10406111
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09671540
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09421011
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09343954
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08523335
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07827103
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07576900
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06429227
109P300_19829295_ChIP-Seq_ESCs_Human1.06366143
110HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06290516
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06192777
112WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05981540
113NANOG_19829295_ChIP-Seq_ESCs_Human1.05497582
114SOX2_19829295_ChIP-Seq_ESCs_Human1.05497582
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05478462
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05368700
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.05278128
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04473152
119CBP_20019798_ChIP-Seq_JUKART_Human1.03724013
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03724013
121* KDM2B_26808549_Chip-Seq_K562_Human1.03359790
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03350983
123IGF1R_20145208_ChIP-Seq_DFB_Human1.03306512
124NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02689484
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02488197
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01948645
127ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01883783
128TAF15_26573619_Chip-Seq_HEK293_Human1.01559659
129SALL4_22934838_ChIP-ChIP_CD34+_Human1.01018364
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00935145
131NOTCH1_21737748_ChIP-Seq_TLL_Human1.00209672
132SMAD4_21799915_ChIP-Seq_A2780_Human0.99515919
133P53_22387025_ChIP-Seq_ESCs_Mouse0.99136656
134* PU_27001747_Chip-Seq_BMDM_Mouse0.98925737
135MYB_26560356_Chip-Seq_TH2_Human0.98880257
136RUNX_20019798_ChIP-Seq_JUKART_Human0.98240687
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97501263
138KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97331423
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.96616220
140STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96160539
141NFE2_27457419_Chip-Seq_LIVER_Mouse0.96081442
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96029347
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95168569
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95130471
145ELK1_19687146_ChIP-ChIP_HELA_Human0.95078287
146AR_19668381_ChIP-Seq_PC3_Human0.94191878
147FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93512519
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.92524823
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92196220
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91346358
151KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91078697
152VDR_23849224_ChIP-Seq_CD4+_Human0.91077647
153ER_23166858_ChIP-Seq_MCF-7_Human0.89973517
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89949000
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.89587668
156SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89253196
157AR_25329375_ChIP-Seq_VCAP_Human0.88807949
158POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87837459
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.87097380
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86361225
161CTCF_27219007_Chip-Seq_Bcells_Human0.84040604
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83206842
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.80802165
164TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80695201
165SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80103289
166KDM2B_26808549_Chip-Seq_DND41_Human0.78117353
167STAT3_23295773_ChIP-Seq_U87_Human0.78016872
168FUS_26573619_Chip-Seq_HEK293_Human0.77959515
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.76984349
170NFIB_24661679_ChIP-Seq_LUNG_Mouse0.76464359
171KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76389374
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.75822935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.16177410
2MP0004145_abnormal_muscle_electrophysio4.50429053
3MP0004859_abnormal_synaptic_plasticity3.73806708
4MP0003880_abnormal_central_pattern3.65839085
5MP0003303_peritoneal_inflammation3.57681897
6MP0003221_abnormal_cardiomyocyte_apopto3.44833404
7MP0004270_analgesia3.40773012
8MP0000751_myopathy3.11751036
9MP0000749_muscle_degeneration2.89347790
10MP0006082_CNS_inflammation2.72434577
11MP0009785_altered_susceptibility_to2.64167390
12MP0001835_abnormal_antigen_presentation2.44947015
13MP0005423_abnormal_somatic_nervous2.37150108
14MP0003646_muscle_fatigue2.34223000
15MP0003635_abnormal_synaptic_transmissio2.31456497
16MP0000747_muscle_weakness2.20662797
17MP0000778_abnormal_nervous_system2.19519283
18MP0009764_decreased_sensitivity_to2.14307119
19MP0003436_decreased_susceptibility_to2.13755024
20MP0002106_abnormal_muscle_physiology2.12678142
21MP0002419_abnormal_innate_immunity2.05246453
22MP0000759_abnormal_skeletal_muscle2.04640178
23MP0003828_pulmonary_edema1.96342105
24MP0005671_abnormal_response_to1.94936356
25MP0002734_abnormal_mechanical_nocicepti1.94325299
26MP0002063_abnormal_learning/memory/cond1.90464932
27MP0005369_muscle_phenotype1.85961494
28MP0005025_abnormal_response_to1.79381560
29MP0002148_abnormal_hypersensitivity_rea1.76252875
30MP0002064_seizures1.75223531
31MP0009278_abnormal_bone_marrow1.72478708
32MP0009745_abnormal_behavioral_response1.72304920
33MP0001486_abnormal_startle_reflex1.71451300
34MP0005000_abnormal_immune_tolerance1.69051853
35MP0004233_abnormal_muscle_weight1.66914442
36MP0005171_absent_coat_pigmentation1.66550384
37MP0002822_catalepsy1.66328129
38MP0004036_abnormal_muscle_relaxation1.65446203
39MP0000920_abnormal_myelination1.65311355
40MP0002272_abnormal_nervous_system1.63472712
41MP0004087_abnormal_muscle_fiber1.62454333
42MP0002132_abnormal_respiratory_system1.62355204
43MP0002184_abnormal_innervation1.61532180
44MP0003122_maternal_imprinting1.61510041
45MP0001800_abnormal_humoral_immune1.60057069
46MP0001968_abnormal_touch/_nociception1.56746746
47MP0005451_abnormal_body_composition1.56656722
48MP0000733_abnormal_muscle_development1.55856483
49MP0000343_altered_response_to1.55539221
50MP0005167_abnormal_blood-brain_barrier1.54904630
51MP0002723_abnormal_immune_serum1.54760072
52MP0008569_lethality_at_weaning1.52048046
53MP0002735_abnormal_chemical_nociception1.50423742
54MP0008260_abnormal_autophagy1.50360959
55MP0005620_abnormal_muscle_contractility1.49480757
56MP0002452_abnormal_antigen_presenting1.49143445
57MP0002837_dystrophic_cardiac_calcinosis1.48625886
58MP0002572_abnormal_emotion/affect_behav1.48453329
59MP0002277_abnormal_respiratory_mucosa1.47958293
60MP0000955_abnormal_spinal_cord1.47580595
61MP0001790_abnormal_immune_system1.44514615
62MP0005387_immune_system_phenotype1.44514615
63MP0005248_abnormal_Harderian_gland1.44007857
64MP0006276_abnormal_autonomic_nervous1.42913858
65MP0006054_spinal_hemorrhage1.41404662
66MP0002067_abnormal_sensory_capabilities1.41010358
67MP0004142_abnormal_muscle_tone1.39554912
68MP0003300_gastrointestinal_ulcer1.39386594
69MP0004883_abnormal_blood_vessel1.39077720
70MP0009046_muscle_twitch1.37752512
71MP0002653_abnormal_ependyma_morphology1.36983225
72MP0004742_abnormal_vestibular_system1.36527076
73MP0002420_abnormal_adaptive_immunity1.34689029
74MP0002733_abnormal_thermal_nociception1.34521911
75MP0000465_gastrointestinal_hemorrhage1.34448637
76MP0001819_abnormal_immune_cell1.34058468
77MP0002269_muscular_atrophy1.33783599
78MP0001970_abnormal_pain_threshold1.32935472
79MP0001299_abnormal_eye_distance/1.32844324
80MP0004811_abnormal_neuron_physiology1.29464375
81MP0006036_abnormal_mitochondrial_physio1.29055608
82MP0009250_abnormal_appendicular_skeleto1.27436182
83MP0003656_abnormal_erythrocyte_physiolo1.26707590
84MP0005266_abnormal_metabolism1.26338847
85MP0002882_abnormal_neuron_morphology1.25661873
86MP0003137_abnormal_impulse_conducting1.25205625
87MP0005409_darkened_coat_color1.24758860
88MP0001440_abnormal_grooming_behavior1.24484509
89MP0000750_abnormal_muscle_regeneration1.23357878
90MP0001529_abnormal_vocalization1.21706459
91MP0000049_abnormal_middle_ear1.17753584
92MP0003806_abnormal_nucleotide_metabolis1.17540486
93MP0004130_abnormal_muscle_cell1.15833355
94MP0002557_abnormal_social/conspecific_i1.14113239
95MP0006035_abnormal_mitochondrial_morpho1.13859826
96MP0005084_abnormal_gallbladder_morpholo1.13576900
97MP0001905_abnormal_dopamine_level1.12746050
98MP0002066_abnormal_motor_capabilities/c1.12553852
99MP0002736_abnormal_nociception_after1.11451510
100MP0010030_abnormal_orbit_morphology1.11433250
101MP0001845_abnormal_inflammatory_respons1.08248535
102MP0002108_abnormal_muscle_morphology1.06407192
103MP0001533_abnormal_skeleton_physiology1.06296001
104MP0004484_altered_response_of1.04890766
105MP0004924_abnormal_behavior1.04756775
106MP0005386_behavior/neurological_phenoty1.04756775
107MP0001545_abnormal_hematopoietic_system1.04275925
108MP0005397_hematopoietic_system_phenotyp1.04275925
109MP0004858_abnormal_nervous_system1.02802534
110MP0002938_white_spotting1.02744071
111MP0004134_abnormal_chest_morphology1.02205714
112MP0004885_abnormal_endolymph0.99040553
113MP0002751_abnormal_autonomic_nervous0.98902790
114MP0002405_respiratory_system_inflammati0.98769247
115MP0003385_abnormal_body_wall0.97760539
116MP0002234_abnormal_pharynx_morphology0.97497849
117MP0008469_abnormal_protein_level0.97383530
118MP0002152_abnormal_brain_morphology0.97372722
119MP0001188_hyperpigmentation0.96998895
120MP0005083_abnormal_biliary_tract0.95045637
121MP0002752_abnormal_somatic_nervous0.94765518
122MP0001502_abnormal_circadian_rhythm0.94583903
123MP0000716_abnormal_immune_system0.93464196
124MP0000858_altered_metastatic_potential0.91214888
125MP0000631_abnormal_neuroendocrine_gland0.89608009
126MP0000685_abnormal_immune_system0.88930783
127MP0004084_abnormal_cardiac_muscle0.88572176
128MP0005376_homeostasis/metabolism_phenot0.88399462
129MP0000689_abnormal_spleen_morphology0.87962543
130MP0005645_abnormal_hypothalamus_physiol0.86661993
131MP0008874_decreased_physiological_sensi0.86540171
132MP0003690_abnormal_glial_cell0.86394278
133MP0001485_abnormal_pinna_reflex0.86185416
134MP0002102_abnormal_ear_morphology0.86045268
135MP0002249_abnormal_larynx_morphology0.85877830
136MP0001348_abnormal_lacrimal_gland0.85159306
137MP0003861_abnormal_nervous_system0.85051270
138MP0005164_abnormal_response_to0.84304551
139MP0004215_abnormal_myocardial_fiber0.84174823
140MP0006292_abnormal_olfactory_placode0.84077172
141MP0004133_heterotaxia0.83995835
142MP0002638_abnormal_pupillary_reflex0.83948205
143MP0005166_decreased_susceptibility_to0.83094867
144MP0003634_abnormal_glial_cell0.82701592
145MP0001544_abnormal_cardiovascular_syste0.82091958
146MP0005385_cardiovascular_system_phenoty0.82091958
147MP0002972_abnormal_cardiac_muscle0.81914535
148MP0008789_abnormal_olfactory_epithelium0.81864401
149MP0003121_genomic_imprinting0.79646628
150MP0003787_abnormal_imprinting0.78703501
151MP0002932_abnormal_joint_morphology0.78666611
152MP0001727_abnormal_embryo_implantation0.78243442
153MP0009765_abnormal_xenobiotic_induced0.78166513
154MP0001542_abnormal_bone_strength0.77827489
155MP0003755_abnormal_palate_morphology0.76956445
156MP0002127_abnormal_cardiovascular_syste0.76839375
157MP0003938_abnormal_ear_development0.76238739
158MP0002177_abnormal_outer_ear0.75749369
159MP0008004_abnormal_stomach_pH0.75237581
160MP0004510_myositis0.72213997
161MP0002722_abnormal_immune_system0.72105857
162MP0003567_abnormal_fetal_cardiomyocyte0.71975165
163MP0001943_abnormal_respiration0.71706779
164MP0002116_abnormal_craniofacial_bone0.71064003
165MP0003942_abnormal_urinary_system0.70857523
166MP0002332_abnormal_exercise_endurance0.70480528
167MP0002114_abnormal_axial_skeleton0.69660354
168MP0005330_cardiomyopathy0.69158948
169MP0002081_perinatal_lethality0.69018835

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.35536282
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.30123224
3Nemaline bodies (HP:0003798)6.13986234
4Exercise-induced myalgia (HP:0003738)5.48932378
5Muscle hypertrophy of the lower extremities (HP:0008968)5.16278639
6Exercise-induced muscle cramps (HP:0003710)4.57859025
7Calf muscle hypertrophy (HP:0008981)4.55214737
8Distal arthrogryposis (HP:0005684)4.33880716
9Round ear (HP:0100830)4.17252155
10Stomatitis (HP:0010280)4.16464324
11Difficulty running (HP:0009046)4.01980324
12Myopathic facies (HP:0002058)3.94864703
13Retrobulbar optic neuritis (HP:0100654)3.93790919
14Optic neuritis (HP:0100653)3.93790919
15Type 1 muscle fiber predominance (HP:0003803)3.90048344
16Recurrent bacterial skin infections (HP:0005406)3.78094976
17Orchitis (HP:0100796)3.70596820
18Myositis (HP:0100614)3.66520912
19EMG: myopathic abnormalities (HP:0003458)3.50378416
20Eczematoid dermatitis (HP:0000976)3.49266926
21Recurrent abscess formation (HP:0002722)3.41405357
22Focal motor seizures (HP:0011153)3.41359219
23Abnormality of the calf musculature (HP:0001430)3.38723446
24Muscle fiber splitting (HP:0003555)3.36803845
25Calcaneovalgus deformity (HP:0001848)3.35485980
26Abnormality of macrophages (HP:0004311)3.24169006
27Disinhibition (HP:0000734)3.22838421
28Myotonia (HP:0002486)3.20152988
29Ankle clonus (HP:0011448)3.15395361
30Absent phalangeal crease (HP:0006109)3.08038598
31Deformed tarsal bones (HP:0008119)3.07287436
32Amyotrophic lateral sclerosis (HP:0007354)3.05399499
33Broad-based gait (HP:0002136)3.04970604
34Shoulder girdle muscle weakness (HP:0003547)3.02482929
35Myokymia (HP:0002411)3.00688479
36Ulnar deviation of the wrist (HP:0003049)2.93621486
37Fetal akinesia sequence (HP:0001989)2.88257266
38Hyporeflexia of lower limbs (HP:0002600)2.86473223
39Keratoconjunctivitis sicca (HP:0001097)2.85121141
40Elevated erythrocyte sedimentation rate (HP:0003565)2.79416947
41Abnormality of the hip-girdle musculature (HP:0001445)2.76438338
42Abnormality of the musculature of the pelvis (HP:0001469)2.76438338
43Recurrent gram-negative bacterial infections (HP:0005420)2.76132290
44Muscle stiffness (HP:0003552)2.70824536
45Keratoconjunctivitis (HP:0001096)2.68370435
46Neck muscle weakness (HP:0000467)2.65753409
47Abnormal finger flexion creases (HP:0006143)2.61882075
48Rhabdomyolysis (HP:0003201)2.60986647
49Malignant hyperthermia (HP:0002047)2.60966541
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.60730370
51Cortical dysplasia (HP:0002539)2.55336541
52Mediastinal lymphadenopathy (HP:0100721)2.55158589
53Encephalitis (HP:0002383)2.53040238
54Pelvic girdle muscle weakness (HP:0003749)2.52835939
55Abnormality of skeletal muscle fiber size (HP:0012084)2.51824506
56Abnormality of the left ventricular outflow tract (HP:0011103)2.43885851
57Subaortic stenosis (HP:0001682)2.43885851
58Spontaneous hematomas (HP:0007420)2.40441148
59Spastic gait (HP:0002064)2.38748925
60Increased variability in muscle fiber diameter (HP:0003557)2.38571084
61Agnosia (HP:0010524)2.36930072
62Rimmed vacuoles (HP:0003805)2.35460246
63Atrophy/Degeneration involving motor neurons (HP:0007373)2.32683017
64Nonprogressive disorder (HP:0003680)2.31586101
65Polyphagia (HP:0002591)2.31513773
66Inappropriate behavior (HP:0000719)2.30847025
67Urticaria (HP:0001025)2.29760486
68Supranuclear gaze palsy (HP:0000605)2.26891513
69Urinary urgency (HP:0000012)2.25402167
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22023246
71Chest pain (HP:0100749)2.18351801
72Myoglobinuria (HP:0002913)2.15920645
73EMG: neuropathic changes (HP:0003445)2.13556586
74Gastrointestinal infarctions (HP:0005244)2.12179963
75Gowers sign (HP:0003391)2.12167775
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10883639
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.10883639
78Episodic fever (HP:0001954)2.09355214
79Loss of speech (HP:0002371)2.08599433
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05905723
81Sudden death (HP:0001699)2.04001603
82Abnormality of the corticospinal tract (HP:0002492)2.02837467
83Focal seizures (HP:0007359)2.02035680
84Abnormality of the shoulder girdle musculature (HP:0001435)2.00985062
85Limb-girdle muscle weakness (HP:0003325)2.00023629
86Epileptic encephalopathy (HP:0200134)1.98426837
87Akinesia (HP:0002304)1.97677625
88Lower limb muscle weakness (HP:0007340)1.97288172
89Peripheral hypomyelination (HP:0007182)1.96493051
90Obstructive lung disease (HP:0006536)1.95923298
91Chronic obstructive pulmonary disease (HP:0006510)1.95923298
92Limb-girdle muscle atrophy (HP:0003797)1.94987151
93Hematochezia (HP:0002573)1.94119782
94Anorexia (HP:0002039)1.93372843
95Limb dystonia (HP:0002451)1.92480026
96Increased IgM level (HP:0003496)1.92199066
97Nasal speech (HP:0001611)1.91302012
98Alacrima (HP:0000522)1.89534568
99Cerebral hypomyelination (HP:0006808)1.88389420
100Recurrent skin infections (HP:0001581)1.87456377
101Bowel incontinence (HP:0002607)1.86922115
102Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85121192
103Hypoplasia of the brainstem (HP:0002365)1.85121192
104Abnormality of the endocardium (HP:0004306)1.84972318
105Progressive inability to walk (HP:0002505)1.84635385
106Abnormality of the foot musculature (HP:0001436)1.84130171
107Mutism (HP:0002300)1.83884054
108Weak cry (HP:0001612)1.83591315
109Hypochromic microcytic anemia (HP:0004840)1.83581425
110Leukocytosis (HP:0001974)1.83174732
111Proximal amyotrophy (HP:0007126)1.82479775
112Polycythemia (HP:0001901)1.82436454
113Atonic seizures (HP:0010819)1.81098802
114Amyloidosis (HP:0011034)1.80180952
115Foot dorsiflexor weakness (HP:0009027)1.79831756
116Polyneuropathy (HP:0001271)1.78739857
117Frequent falls (HP:0002359)1.76417946
118Exertional dyspnea (HP:0002875)1.75950746
119Insidious onset (HP:0003587)1.75399447
120Termporal pattern (HP:0011008)1.75399447
121Asymmetric septal hypertrophy (HP:0001670)1.74275219
122Difficulty climbing stairs (HP:0003551)1.74264134
123Lipid accumulation in hepatocytes (HP:0006561)1.72073020
124Increased intramyocellular lipid droplets (HP:0012240)1.71992170
125Areflexia of lower limbs (HP:0002522)1.71959096
126Obstructive sleep apnea (HP:0002870)1.71139327
127Scapular winging (HP:0003691)1.71042282
128Abnormal large intestine physiology (HP:0012700)1.69494616
129Hemoptysis (HP:0002105)1.68187655
130Increased hepatocellular lipid droplets (HP:0006565)1.67604550
131Lissencephaly (HP:0001339)1.67551222
132Respiratory insufficiency due to muscle weakness (HP:0002747)1.67255218
133Recurrent fungal infections (HP:0002841)1.65838610
134Diminished motivation (HP:0000745)1.65441393
135T lymphocytopenia (HP:0005403)1.65293374
136Agitation (HP:0000713)1.64015189
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64014032
138Abnormality of alanine metabolism (HP:0010916)1.64014032
139Hyperalaninemia (HP:0003348)1.64014032
140Stridor (HP:0010307)1.63530157
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.63118960
142Megalencephaly (HP:0001355)1.62348602
143Poor eye contact (HP:0000817)1.62343448
144Lower limb amyotrophy (HP:0007210)1.62281800
145Pheochromocytoma (HP:0002666)1.61461448
146Gait imbalance (HP:0002141)1.61211543
147Ulnar deviation of finger (HP:0009465)1.60061100
148Gangrene (HP:0100758)1.59816212
149Dysmetria (HP:0001310)1.59691864
150Retinal dysplasia (HP:0007973)1.59628367
151Vasculitis (HP:0002633)1.59613985
152Impaired vibration sensation in the lower limbs (HP:0002166)1.59469091
153Poor speech (HP:0002465)1.59397149
154Bulbar palsy (HP:0001283)1.58855604
155Congenital primary aphakia (HP:0007707)1.58575267
156Abnormality of the calcaneus (HP:0008364)1.58573770
157Visual hallucinations (HP:0002367)1.58335366
158Increased muscle lipid content (HP:0009058)1.57797751
159Hyperkalemia (HP:0002153)1.56714326
160Decreased lacrimation (HP:0000633)1.56353290
161Abnormality of the neuromuscular junction (HP:0003398)1.55962870
162Fatigable weakness (HP:0003473)1.55962870
163Adducted thumb (HP:0001181)1.55686085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.31615539
2PHKG24.12230567
3PHKG14.12230567
4LIMK13.04843560
5OBSCN2.95160222
6DYRK32.92839417
7CASK2.70215293
8TRIM282.44415764
9MAP3K62.39851638
10UHMK12.16861705
11CDK192.14585735
12MAP2K32.07627619
13TTN2.05975041
14EPHA32.04705216
15KSR12.02777553
16DYRK21.97956164
17BLK1.94911427
18NTRK31.94865573
19IRAK41.90142382
20SIK31.84629701
21NME11.83012850
22MAP3K51.76989281
23MAP3K91.71340195
24EPHA41.70455890
25TAOK11.68851897
26DMPK1.68739276
27RIPK41.67476173
28DYRK1B1.66002449
29PAK61.64123010
30NTRK21.62052333
31PRPF4B1.61494003
32MINK11.57780175
33MATK1.52295054
34CSK1.51345773
35PKN11.50825793
36ERBB31.50232140
37BCR1.49688570
38MAPK131.46077458
39RPS6KA41.44220194
40MAP3K121.42786012
41TAOK31.42542421
42MAP3K41.41215820
43TYK21.38960152
44CSNK1A1L1.35454599
45BCKDK1.33685248
46CSNK1G31.32334811
47GRK71.31032592
48OXSR11.29801783
49CSNK1G21.24966266
50EPHB11.23120908
51TNIK1.13800267
52MAP2K71.12832210
53STK391.12569845
54IRAK21.08962803
55FGFR21.08901763
56CDK51.08168226
57MARK21.07285838
58EPHB21.06094710
59BMPR21.05821558
60SRPK11.04570715
61TXK1.04204241
62BMPR1B1.02190220
63PINK11.01511250
64MAP2K41.01400389
65ICK0.99131618
66LATS20.97271573
67MUSK0.97060034
68CAMK2B0.97036951
69CDK140.96544806
70MAP3K140.96345096
71CSNK1G10.94563049
72MAP4K20.94483186
73ROCK20.93576964
74IKBKE0.90063764
75ZAP700.89202658
76WNK10.88743913
77SGK4940.87874139
78SGK2230.87874139
79ADRBK20.87359801
80MAPK120.86996012
81MAPK70.86693788
82SIK20.85535423
83CDK180.84374719
84NEK60.83762136
85KSR20.83194996
86MAP3K110.83194830
87PAK30.82064916
88JAK20.81908949
89HCK0.81537025
90CAMKK20.80120886
91LYN0.78540620
92TBK10.78487090
93WNK30.77985463
94CAMK2G0.77768482
95MAP3K30.77408226
96TYRO30.77213014
97CDK150.76391041
98CAMK40.76202060
99SYK0.72969745
100MAP3K10.72733710
101MAP4K10.72204632
102MAP3K70.70546016
103PBK0.70044945
104CAMK2A0.69970274
105CDK11A0.68582179
106ILK0.67946597
107PIK3CA0.67048059
108CAMK2D0.66493426
109DAPK20.58724399
110PRKD10.58121409
111RAF10.57717146
112TAOK20.57263904
113PIK3CG0.57155093
114ACVR1B0.55245378
115SGK10.55056705
116MARK30.54863085
117TESK20.54739456
118JAK30.54009819
119PNCK0.52365214
120DDR20.49445673
121ARAF0.49205756
122BTK0.48938935
123YES10.46123561
124LCK0.45623571
125EGFR0.44581431
126MKNK20.44216194
127PRKCE0.44211278
128PLK20.44032813
129TNK20.43888844
130FYN0.43640445
131ROCK10.43358141
132HIPK20.41932455
133DYRK1A0.40966201
134PRKG10.39832510
135FGR0.38984235
136PIM20.38129792
137NEK10.37972828
138STK110.37835395
139IRAK10.37812835
140MKNK10.37386476
141PLK40.37206458
142TESK10.36644632
143MAPK100.34723341
144MAP2K60.32007235
145PRKCG0.29681883
146DAPK30.29679987
147FES0.29331695
148FGFR10.28946660
149CAMK10.28826182
150CDC42BPA0.28623539
151CCNB10.27721823
152MAPK90.27422440

Predicted pathways (KEGG)

RankGene SetZ-score
1Legionellosis_Homo sapiens_hsa051342.88748802
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.70260463
3Osteoclast differentiation_Homo sapiens_hsa043802.68543448
4Leishmaniasis_Homo sapiens_hsa051402.63723188
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.43124846
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35350743
7Tuberculosis_Homo sapiens_hsa051522.34662610
8Axon guidance_Homo sapiens_hsa043602.27068218
9Staphylococcus aureus infection_Homo sapiens_hsa051502.26513618
10Rheumatoid arthritis_Homo sapiens_hsa053231.95310339
11Circadian entrainment_Homo sapiens_hsa047131.89993038
12Nicotine addiction_Homo sapiens_hsa050331.88753115
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79149153
14Cardiac muscle contraction_Homo sapiens_hsa042601.78605758
15Morphine addiction_Homo sapiens_hsa050321.77340427
16GABAergic synapse_Homo sapiens_hsa047271.76959020
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73571479
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73319708
19Oxytocin signaling pathway_Homo sapiens_hsa049211.72555402
20Dilated cardiomyopathy_Homo sapiens_hsa054141.71882725
21Graft-versus-host disease_Homo sapiens_hsa053321.71857781
22Malaria_Homo sapiens_hsa051441.70952088
23Pertussis_Homo sapiens_hsa051331.70943513
24Glutamatergic synapse_Homo sapiens_hsa047241.68546604
25Synaptic vesicle cycle_Homo sapiens_hsa047211.67303158
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66379564
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62737166
28Allograft rejection_Homo sapiens_hsa053301.62516779
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56631585
30Regulation of autophagy_Homo sapiens_hsa041401.54725338
31Long-term potentiation_Homo sapiens_hsa047201.53679674
32Dopaminergic synapse_Homo sapiens_hsa047281.52299084
33Long-term depression_Homo sapiens_hsa047301.50876429
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50790202
35Serotonergic synapse_Homo sapiens_hsa047261.43234716
36Cholinergic synapse_Homo sapiens_hsa047251.42618917
37Olfactory transduction_Homo sapiens_hsa047401.42565278
38Cocaine addiction_Homo sapiens_hsa050301.30223715
39Gap junction_Homo sapiens_hsa045401.29811769
40Protein export_Homo sapiens_hsa030601.28107079
41TNF signaling pathway_Homo sapiens_hsa046681.28022908
42Renal cell carcinoma_Homo sapiens_hsa052111.25211573
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22874505
44Asthma_Homo sapiens_hsa053101.22435223
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21896781
46Gastric acid secretion_Homo sapiens_hsa049711.21462496
47Wnt signaling pathway_Homo sapiens_hsa043101.21435057
48ErbB signaling pathway_Homo sapiens_hsa040121.20919051
49Autoimmune thyroid disease_Homo sapiens_hsa053201.20667253
50Amphetamine addiction_Homo sapiens_hsa050311.20025466
51Calcium signaling pathway_Homo sapiens_hsa040201.19874795
52Type I diabetes mellitus_Homo sapiens_hsa049401.19763860
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17485720
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14493831
55MAPK signaling pathway_Homo sapiens_hsa040101.14434410
56Circadian rhythm_Homo sapiens_hsa047101.13834224
57Renin secretion_Homo sapiens_hsa049241.12762647
58GnRH signaling pathway_Homo sapiens_hsa049121.12372261
59Hedgehog signaling pathway_Homo sapiens_hsa043401.12011417
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12003412
61Melanogenesis_Homo sapiens_hsa049161.11529728
62NF-kappa B signaling pathway_Homo sapiens_hsa040641.10687646
63Influenza A_Homo sapiens_hsa051641.09652154
64Measles_Homo sapiens_hsa051621.09433527
65Viral myocarditis_Homo sapiens_hsa054161.08191870
66Toxoplasmosis_Homo sapiens_hsa051451.06880552
67Basal cell carcinoma_Homo sapiens_hsa052171.06028655
68Colorectal cancer_Homo sapiens_hsa052101.05691535
69Insulin secretion_Homo sapiens_hsa049111.05301499
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01467573
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01259161
72Tight junction_Homo sapiens_hsa045301.01066238
73African trypanosomiasis_Homo sapiens_hsa051431.00691302
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99568162
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96285511
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95743933
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95438897
78Hippo signaling pathway_Homo sapiens_hsa043900.94919187
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.94306690
80Salmonella infection_Homo sapiens_hsa051320.94123880
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93934942
82Herpes simplex infection_Homo sapiens_hsa051680.93137625
83Hematopoietic cell lineage_Homo sapiens_hsa046400.92270951
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92107433
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91995929
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91544444
87cAMP signaling pathway_Homo sapiens_hsa040240.90094061
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90000556
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89069221
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.88400044
91Ras signaling pathway_Homo sapiens_hsa040140.88158320
92Endocytosis_Homo sapiens_hsa041440.87138442
93Salivary secretion_Homo sapiens_hsa049700.86488755
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86436355
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86119846
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85466943
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84544900
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.83412150
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83320442
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.83166312
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82524396
102Vibrio cholerae infection_Homo sapiens_hsa051100.80263841
103VEGF signaling pathway_Homo sapiens_hsa043700.79970772
104Hepatitis B_Homo sapiens_hsa051610.78930988
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78864641
106Oocyte meiosis_Homo sapiens_hsa041140.78044116
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.77957392
108Parkinsons disease_Homo sapiens_hsa050120.77909452
109Notch signaling pathway_Homo sapiens_hsa043300.77882324
110Insulin signaling pathway_Homo sapiens_hsa049100.77448091
111B cell receptor signaling pathway_Homo sapiens_hsa046620.76646346
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76441397
113Glioma_Homo sapiens_hsa052140.76414279
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76075339
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75852053
116Shigellosis_Homo sapiens_hsa051310.75702868
117Taste transduction_Homo sapiens_hsa047420.75182267
118Choline metabolism in cancer_Homo sapiens_hsa052310.74760836
119T cell receptor signaling pathway_Homo sapiens_hsa046600.74601590
120Antigen processing and presentation_Homo sapiens_hsa046120.73522192
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.72655184
122Alzheimers disease_Homo sapiens_hsa050100.71875109
123Type II diabetes mellitus_Homo sapiens_hsa049300.71635777
124Endometrial cancer_Homo sapiens_hsa052130.71230394
125Steroid biosynthesis_Homo sapiens_hsa001000.70452900
126Rap1 signaling pathway_Homo sapiens_hsa040150.70025871
127Lysosome_Homo sapiens_hsa041420.69573309
128Dorso-ventral axis formation_Homo sapiens_hsa043200.65413746
129Huntingtons disease_Homo sapiens_hsa050160.63751682
130Chemokine signaling pathway_Homo sapiens_hsa040620.62018976
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61220408
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59997982
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58958247
134Collecting duct acid secretion_Homo sapiens_hsa049660.58677113
135Oxidative phosphorylation_Homo sapiens_hsa001900.57903580
136Adherens junction_Homo sapiens_hsa045200.56819843
137Epstein-Barr virus infection_Homo sapiens_hsa051690.56671138
138Phagosome_Homo sapiens_hsa041450.56584144
139Focal adhesion_Homo sapiens_hsa045100.56412764
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56308266
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56271596
142Proteoglycans in cancer_Homo sapiens_hsa052050.56121467
143Melanoma_Homo sapiens_hsa052180.55937740
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55578616
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55442971
146Estrogen signaling pathway_Homo sapiens_hsa049150.54609923
147FoxO signaling pathway_Homo sapiens_hsa040680.52577314
148Hepatitis C_Homo sapiens_hsa051600.52134541
149Platelet activation_Homo sapiens_hsa046110.51677538
150Leukocyte transendothelial migration_Homo sapiens_hsa046700.50863872
151RNA degradation_Homo sapiens_hsa030180.48249274
152Prolactin signaling pathway_Homo sapiens_hsa049170.45242567
153Peroxisome_Homo sapiens_hsa041460.44080634
154Propanoate metabolism_Homo sapiens_hsa006400.43520162
155* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43195260
156HIF-1 signaling pathway_Homo sapiens_hsa040660.42261862
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.40677061
158Folate biosynthesis_Homo sapiens_hsa007900.40522756
159Fatty acid elongation_Homo sapiens_hsa000620.40132860
1602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40084573
161Apoptosis_Homo sapiens_hsa042100.32554242
162Phototransduction_Homo sapiens_hsa047440.31503494

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