UBE2D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.71509315
2mitotic chromosome condensation (GO:0007076)4.44675793
3metaphase plate congression (GO:0051310)4.17967097
4proteasome assembly (GO:0043248)4.11643011
5establishment of chromosome localization (GO:0051303)3.91905747
6mitotic nuclear envelope disassembly (GO:0007077)3.90707283
7CENP-A containing nucleosome assembly (GO:0034080)3.90283033
8attachment of spindle microtubules to kinetochore (GO:0008608)3.87733386
9DNA double-strand break processing (GO:0000729)3.85731404
10chromatin remodeling at centromere (GO:0031055)3.83881799
11nuclear pore complex assembly (GO:0051292)3.79042876
12nuclear pore organization (GO:0006999)3.75502275
13protein localization to kinetochore (GO:0034501)3.74113365
14DNA replication-independent nucleosome assembly (GO:0006336)3.73219669
15DNA replication-independent nucleosome organization (GO:0034724)3.73219669
16membrane disassembly (GO:0030397)3.72955026
17nuclear envelope disassembly (GO:0051081)3.72955026
18meiotic chromosome segregation (GO:0045132)3.71329576
19DNA replication checkpoint (GO:0000076)3.68672932
20mitotic sister chromatid cohesion (GO:0007064)3.68386032
21cullin deneddylation (GO:0010388)3.62570260
22kinetochore organization (GO:0051383)3.58819190
23regulation of spindle organization (GO:0090224)3.58009470
24protein localization to chromosome, centromeric region (GO:0071459)3.57730722
25regulation of helicase activity (GO:0051095)3.40598285
26regulation of sister chromatid cohesion (GO:0007063)3.33318860
27ribosome assembly (GO:0042255)3.31892555
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31124728
29protein deneddylation (GO:0000338)3.29879653
30histone exchange (GO:0043486)3.28115923
31DNA ligation (GO:0006266)3.26725402
32spindle checkpoint (GO:0031577)3.26419329
33DNA replication initiation (GO:0006270)3.24206617
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24058951
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24058951
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.24058951
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22975844
38negative regulation of DNA recombination (GO:0045910)3.15665406
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15434963
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13582045
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13527463
42regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13412860
43regulation of chromosome segregation (GO:0051983)3.13258378
44kinetochore assembly (GO:0051382)3.11981575
45positive regulation of gamma-delta T cell activation (GO:0046645)3.10941572
46folic acid-containing compound biosynthetic process (GO:0009396)3.10775198
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.09180709
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09180709
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09180709
50negative regulation of sister chromatid segregation (GO:0033046)3.09180709
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09160245
52spindle assembly checkpoint (GO:0071173)3.08633896
53DNA replication-dependent nucleosome assembly (GO:0006335)3.07847325
54DNA replication-dependent nucleosome organization (GO:0034723)3.07847325
55mitotic sister chromatid segregation (GO:0000070)3.07288231
56protein localization to chromosome (GO:0034502)3.06923031
57regulation of mitotic spindle organization (GO:0060236)3.06751975
58somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.06554765
59isotype switching (GO:0045190)3.06554765
60somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.06554765
61mitotic G2/M transition checkpoint (GO:0044818)3.05983979
62mitotic spindle assembly checkpoint (GO:0007094)3.05875876
63negative regulation of chromosome segregation (GO:0051985)3.04775947
64monoubiquitinated protein deubiquitination (GO:0035520)3.04461494
65DNA strand elongation involved in DNA replication (GO:0006271)3.02852819
66positive regulation of chromosome segregation (GO:0051984)3.02640644
67sister chromatid segregation (GO:0000819)3.02192122
68histone H2A monoubiquitination (GO:0035518)3.01316381
69negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.00659276
70mitotic spindle checkpoint (GO:0071174)3.00105103
71chromosome segregation (GO:0007059)2.99463221
72protein K6-linked ubiquitination (GO:0085020)2.97553640
73neutrophil activation involved in immune response (GO:0002283)2.97285371
74chromatin assembly or disassembly (GO:0006333)2.96005133
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95418154
76telomere maintenance via recombination (GO:0000722)2.93677010
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93436191
78regulation of sister chromatid segregation (GO:0033045)2.93028644
79regulation of mitotic sister chromatid separation (GO:0010965)2.93028644
80regulation of mitotic sister chromatid segregation (GO:0033047)2.93028644
81regulation of centrosome cycle (GO:0046605)2.92705696
82nuclear envelope organization (GO:0006998)2.92577632
83DNA unwinding involved in DNA replication (GO:0006268)2.90400036
84DNA strand elongation (GO:0022616)2.90215280
85regulation of centriole replication (GO:0046599)2.89676755
86mitotic G2 DNA damage checkpoint (GO:0007095)2.88386123
87mitotic recombination (GO:0006312)2.87639144
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87001943
89negative regulation of ligase activity (GO:0051352)2.87001943
90pore complex assembly (GO:0046931)2.81943311
91telomere maintenance via semi-conservative replication (GO:0032201)2.81399159
92regulation of telomere maintenance via telomerase (GO:0032210)2.79611343
93positive regulation of granulocyte differentiation (GO:0030854)2.79118928
94regulation of double-strand break repair via homologous recombination (GO:0010569)2.78015731
95establishment of integrated proviral latency (GO:0075713)2.77597412
96regulation of histone H3-K27 methylation (GO:0061085)2.76562714
97maturation of 5.8S rRNA (GO:0000460)2.76042718
98histone mRNA catabolic process (GO:0071044)2.74911593
99DNA damage induced protein phosphorylation (GO:0006975)2.72960561
100regulation of B cell receptor signaling pathway (GO:0050855)2.72631218
101purine nucleobase biosynthetic process (GO:0009113)2.72417176
102DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.68206148
103sister chromatid cohesion (GO:0007062)2.65354773
104IMP metabolic process (GO:0046040)2.64662979
105negative regulation of meiosis (GO:0045835)2.62030394
106RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60688933
107DNA damage response, signal transduction resulting in transcription (GO:0042772)2.59979065
108DNA catabolic process, exonucleolytic (GO:0000738)2.59958629
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59801431
110double-strand break repair via nonhomologous end joining (GO:0006303)2.58492630
111non-recombinational repair (GO:0000726)2.58492630
112somatic cell DNA recombination (GO:0016444)2.57807133
113somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.57807133
114dosage compensation (GO:0007549)2.57791821
115negative regulation of histone methylation (GO:0031061)2.57713147
116ATP-dependent chromatin remodeling (GO:0043044)2.56705389
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.55786167
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55433825
119translesion synthesis (GO:0019985)2.53651470
120histone mRNA metabolic process (GO:0008334)2.52985013
121regulation of mitotic spindle checkpoint (GO:1903504)2.52871405
122regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.52871405
123histone H2A ubiquitination (GO:0033522)2.52857533
124IMP biosynthetic process (GO:0006188)2.52596452
125positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.52479731
126mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.52479731
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.51991452
128telomere maintenance via telomere lengthening (GO:0010833)2.51630625
129organelle disassembly (GO:1903008)2.50865968
130protein neddylation (GO:0045116)2.49680415
131N-terminal protein amino acid acetylation (GO:0006474)2.49099999
132DNA duplex unwinding (GO:0032508)2.47179521
133piRNA metabolic process (GO:0034587)2.46928694
134positive regulation of ligase activity (GO:0051351)2.46881073
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46526689
136negative regulation of mitosis (GO:0045839)2.46019672
137DNA geometric change (GO:0032392)2.45691406
138nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.45332462
139negative regulation of cell division (GO:0051782)2.43978142
140positive regulation of B cell differentiation (GO:0045579)2.43807218
141regulation of cellular amino acid metabolic process (GO:0006521)2.43585016
142signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.42986806
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.42986806
144signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.42986806
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42361396
146intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42361396
147nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41296705
148regulation of ubiquitin-protein transferase activity (GO:0051438)2.41275189
149negative regulation of nuclear division (GO:0051784)2.41117234
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.40972305
151somatic diversification of immune receptors (GO:0002200)2.40452796
152regulation of chromatin silencing (GO:0031935)2.39920331
153B cell mediated immunity (GO:0019724)2.39877136
154positive regulation of alpha-beta T cell proliferation (GO:0046641)2.38213853
155positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.36564973
156establishment of viral latency (GO:0019043)2.36222861
157antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.35150603
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.34738284
159regulation of ligase activity (GO:0051340)2.34379780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.75232737
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.14354970
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75926033
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.52886552
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.30183355
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.06149023
7AR_21909140_ChIP-Seq_LNCAP_Human2.70893138
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55704168
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.32172909
10NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25517532
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23803443
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22572311
13* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10349704
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.08197666
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07534434
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07061385
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.04635507
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00793783
19* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92401892
20MYC_22102868_ChIP-Seq_BL_Human1.91624031
21VDR_23849224_ChIP-Seq_CD4+_Human1.87613167
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87481808
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87090470
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86229371
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.79730199
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79440375
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.78878955
28* ELK1_19687146_ChIP-ChIP_HELA_Human1.67848914
29* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67495978
30IGF1R_20145208_ChIP-Seq_DFB_Human1.63758468
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62947121
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.61247087
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60602091
34* SMAD_19615063_ChIP-ChIP_OVARY_Human1.60459528
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60394051
36XRN2_22483619_ChIP-Seq_HELA_Human1.57481260
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.55352301
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54307520
39DCP1A_22483619_ChIP-Seq_HELA_Human1.51498019
40EWS_26573619_Chip-Seq_HEK293_Human1.50098470
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49519844
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.48733981
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48525909
44* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47970711
45GABP_19822575_ChIP-Seq_HepG2_Human1.47232327
46FOXP3_21729870_ChIP-Seq_TREG_Human1.46314893
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43034475
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41330041
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41151544
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41080575
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.39502983
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.39089355
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38837180
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38729035
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38497850
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38382007
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38273585
58CIITA_25753668_ChIP-Seq_RAJI_Human1.38202736
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36942794
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36176391
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35254194
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34449532
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34449532
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34449532
65KDM5A_27292631_Chip-Seq_BREAST_Human1.33277217
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32803709
67MYB_26560356_Chip-Seq_TH2_Human1.32664611
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31496213
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30894844
70TFEB_21752829_ChIP-Seq_HELA_Human1.28946675
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28854104
72* SPI1_23547873_ChIP-Seq_NB4_Human1.26697674
73* TTF2_22483619_ChIP-Seq_HELA_Human1.26599592
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24932263
75FUS_26573619_Chip-Seq_HEK293_Human1.24292032
76TAF15_26573619_Chip-Seq_HEK293_Human1.23627642
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23370324
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23081862
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22423137
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22114735
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21494487
82MYB_26560356_Chip-Seq_TH1_Human1.20932737
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20466552
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19427021
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18409327
86* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17910743
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.16910182
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.13847495
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12888957
90* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11992674
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07988824
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07740079
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.07574170
94GATA3_26560356_Chip-Seq_TH2_Human1.07437952
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04492915
96* GATA3_27048872_Chip-Seq_THYMUS_Human1.02859909
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02708727
98* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02121783
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.01710788
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01138130
101* SALL4_22934838_ChIP-ChIP_CD34+_Human0.98698904
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98166723
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97835387
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97781322
105RUNX_20019798_ChIP-Seq_JUKART_Human0.96751075
106IRF1_19129219_ChIP-ChIP_H3396_Human0.96072130
107SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94710867
108UTX_26944678_Chip-Seq_JUKART_Human0.94351917
109* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93618441
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91585173
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90855023
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90657304
113ZNF274_21170338_ChIP-Seq_K562_Hela0.89963729
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89883724
115* SRF_21415370_ChIP-Seq_HL-1_Mouse0.89781470
116P300_19829295_ChIP-Seq_ESCs_Human0.89555724
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89205607
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88976841
119MAF_26560356_Chip-Seq_TH1_Human0.88752238
120GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88284089
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87006165
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86268857
123MYC_18940864_ChIP-ChIP_HL60_Human0.84449580
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84212228
125* HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82370459
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80575387
127* RUNX1_22412390_ChIP-Seq_EML_Mouse0.79961145
128GATA1_22025678_ChIP-Seq_K562_Human0.79825774
129VDR_21846776_ChIP-Seq_THP-1_Human0.79220945
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78764019
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.78242954
132* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78197643
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77241203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.44291429
2MP0010094_abnormal_chromosome_stability3.53982702
3MP0003111_abnormal_nucleus_morphology3.34351003
4MP0003077_abnormal_cell_cycle3.22885143
5MP0004957_abnormal_blastocyst_morpholog3.13704367
6MP0008057_abnormal_DNA_replication2.84703434
7MP0003221_abnormal_cardiomyocyte_apopto2.79063493
8MP0002009_preneoplasia2.75884626
9MP0008007_abnormal_cellular_replicative2.42641376
10MP0010352_gastrointestinal_tract_polyps2.20762437
11MP0008058_abnormal_DNA_repair2.19855499
12MP0003763_abnormal_thymus_physiology2.01318215
13MP0002396_abnormal_hematopoietic_system1.96129364
14MP0009697_abnormal_copulation1.91854923
15MP0008260_abnormal_autophagy1.81330078
16MP0010307_abnormal_tumor_latency1.77211927
17MP0000350_abnormal_cell_proliferation1.74752885
18MP0008932_abnormal_embryonic_tissue1.74427825
19MP0003718_maternal_effect1.73393419
20MP0008877_abnormal_DNA_methylation1.71042167
21MP0003123_paternal_imprinting1.70393486
22MP0005075_abnormal_melanosome_morpholog1.69970399
23MP0002254_reproductive_system_inflammat1.65266067
24MP0000490_abnormal_crypts_of1.64128962
25MP0001730_embryonic_growth_arrest1.63903456
26MP0005076_abnormal_cell_differentiation1.63507666
27MP0006082_CNS_inflammation1.60299292
28MP0004808_abnormal_hematopoietic_stem1.59784516
29MP0010234_abnormal_vibrissa_follicle1.54296143
30MP0002006_tumorigenesis1.42757773
31MP0000569_abnormal_digit_pigmentation1.42178591
32MP0002019_abnormal_tumor_incidence1.39569099
33MP0001697_abnormal_embryo_size1.38625117
34MP0006054_spinal_hemorrhage1.38089571
35MP0005397_hematopoietic_system_phenotyp1.33536197
36MP0001545_abnormal_hematopoietic_system1.33536197
37MP0002398_abnormal_bone_marrow1.32697646
38MP0001835_abnormal_antigen_presentation1.32444779
39MP0000703_abnormal_thymus_morphology1.30954448
40MP0005387_immune_system_phenotype1.30773704
41MP0005380_embryogenesis_phenotype1.30668672
42MP0001672_abnormal_embryogenesis/_devel1.30668672
43MP0002877_abnormal_melanocyte_morpholog1.27705156
44MP0003656_abnormal_erythrocyte_physiolo1.27531669
45MP0003300_gastrointestinal_ulcer1.26468580
46MP0009333_abnormal_splenocyte_physiolog1.24155744
47MP0002166_altered_tumor_susceptibility1.23566032
48MP0002148_abnormal_hypersensitivity_rea1.21896835
49MP0001800_abnormal_humoral_immune1.21200281
50MP0003984_embryonic_growth_retardation1.20535390
51MP0006035_abnormal_mitochondrial_morpho1.19819293
52MP0002086_abnormal_extraembryonic_tissu1.19378323
53MP0001119_abnormal_female_reproductive1.18976736
54MP0002088_abnormal_embryonic_growth/wei1.18367020
55MP0002796_impaired_skin_barrier1.16488764
56MP0000689_abnormal_spleen_morphology1.16248592
57MP0002085_abnormal_embryonic_tissue1.16070175
58MP0003436_decreased_susceptibility_to1.16008221
59MP0001853_heart_inflammation1.15899711
60MP0002722_abnormal_immune_system1.15561487
61MP0005671_abnormal_response_to1.15246336
62MP0002084_abnormal_developmental_patter1.14404514
63MP0000858_altered_metastatic_potential1.14265734
64MP0008789_abnormal_olfactory_epithelium1.13255862
65MP0003806_abnormal_nucleotide_metabolis1.13242573
66MP0001188_hyperpigmentation1.13082103
67MP0002102_abnormal_ear_morphology1.12620615
68MP0002080_prenatal_lethality1.10274031
69MP0004264_abnormal_extraembryonic_tissu1.08332246
70MP0002452_abnormal_antigen_presenting1.08323345
71MP0000313_abnormal_cell_death1.07041131
72MP0000685_abnormal_immune_system1.04971368
73MP0004947_skin_inflammation1.04786858
74MP0006036_abnormal_mitochondrial_physio1.03955100
75MP0003566_abnormal_cell_adhesion1.02602821
76MP0002405_respiratory_system_inflammati1.01842652
77MP0005023_abnormal_wound_healing1.01497713
78MP0002420_abnormal_adaptive_immunity1.01479088
79MP0000716_abnormal_immune_system1.00966251
80MP0001819_abnormal_immune_cell1.00936361
81MP0005000_abnormal_immune_tolerance0.98631433
82MP0003787_abnormal_imprinting0.97744106
83MP0001873_stomach_inflammation0.97203983
84MP0002723_abnormal_immune_serum0.97085916
85MP0002429_abnormal_blood_cell0.95981163
86MP0003786_premature_aging0.95556704
87MP0001915_intracranial_hemorrhage0.95333867
88MP0002210_abnormal_sex_determination0.94489316
89MP0003121_genomic_imprinting0.93604921
90MP0003646_muscle_fatigue0.93088804
91MP0005621_abnormal_cell_physiology0.93058563
92MP0010155_abnormal_intestine_physiology0.91993181
93MP0005395_other_phenotype0.91733499
94MP0001191_abnormal_skin_condition0.91595967
95MP0004197_abnormal_fetal_growth/weight/0.90301696
96MP0004484_altered_response_of0.89385626
97MP0003724_increased_susceptibility_to0.88812375
98MP0005408_hypopigmentation0.88663745
99MP0003448_altered_tumor_morphology0.88203439
100MP0003699_abnormal_female_reproductive0.86959695
101MP0003941_abnormal_skin_development0.86948553
102MP0003828_pulmonary_edema0.86629110
103MP0000653_abnormal_sex_gland0.86216900
104MP0001929_abnormal_gametogenesis0.85237763
105MP0003705_abnormal_hypodermis_morpholog0.83709294
106MP0001177_atelectasis0.83170108
107MP0009278_abnormal_bone_marrow0.80509248
108MP0003453_abnormal_keratinocyte_physiol0.80348171
109MP0008995_early_reproductive_senescence0.79861154
110MP0001529_abnormal_vocalization0.79520243
111MP0005084_abnormal_gallbladder_morpholo0.79365563
112MP0002138_abnormal_hepatobiliary_system0.79362858
113MP0009785_altered_susceptibility_to0.79265116
114MP0002277_abnormal_respiratory_mucosa0.79026193
115MP0002132_abnormal_respiratory_system0.77985123
116MP0001145_abnormal_male_reproductive0.77940194
117MP0005501_abnormal_skin_physiology0.77719243
118MP0005384_cellular_phenotype0.77192839
119MP0000427_abnormal_hair_cycle0.76731950
120MP0005464_abnormal_platelet_physiology0.76691221
121MP0005499_abnormal_olfactory_system0.76587446
122MP0005394_taste/olfaction_phenotype0.76587446
123MP0004147_increased_porphyrin_level0.76469817
124MP0003890_abnormal_embryonic-extraembry0.76118732
125MP0002419_abnormal_innate_immunity0.74154853
126MP0000465_gastrointestinal_hemorrhage0.74011224
127MP0001845_abnormal_inflammatory_respons0.72469170
128MP0001293_anophthalmia0.70554419
129MP0005025_abnormal_response_to0.69778873
130MP0003567_abnormal_fetal_cardiomyocyte0.69341639
131MP0001790_abnormal_immune_system0.69126886

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.78050210
2Chromsome breakage (HP:0040012)3.90212356
3Stomatitis (HP:0010280)3.61831228
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47197336
5Breast hypoplasia (HP:0003187)3.33161545
6B lymphocytopenia (HP:0010976)3.32474853
7Abnormality of the fingertips (HP:0001211)3.21361182
8Abnormality of B cell number (HP:0010975)3.09604725
9Abnormality of chromosome stability (HP:0003220)3.03749017
10Amyotrophic lateral sclerosis (HP:0007354)2.92910881
11Acute myeloid leukemia (HP:0004808)2.92473792
12Gonadotropin excess (HP:0000837)2.90886265
13Thyroiditis (HP:0100646)2.71085966
14Aplastic anemia (HP:0001915)2.67041833
15Atrophy/Degeneration involving motor neurons (HP:0007373)2.65167368
16Thyroid carcinoma (HP:0002890)2.61513627
17Facial hemangioma (HP:0000329)2.59490096
18Embryonal renal neoplasm (HP:0011794)2.57926923
19Patellar aplasia (HP:0006443)2.57849427
20Myelodysplasia (HP:0002863)2.57028404
21Nephroblastoma (Wilms tumor) (HP:0002667)2.48628413
22Abnormality of the preputium (HP:0100587)2.47756986
23Meckel diverticulum (HP:0002245)2.45440636
24Papillary thyroid carcinoma (HP:0002895)2.42100351
25Hypoplasia of the thymus (HP:0000778)2.42013670
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.41674400
27IgM deficiency (HP:0002850)2.39215887
28Oral leukoplakia (HP:0002745)2.38605164
29Ectopic kidney (HP:0000086)2.35919626
30Aplasia/Hypoplasia of the patella (HP:0006498)2.35534627
31Carpal bone hypoplasia (HP:0001498)2.30176887
32Increased IgM level (HP:0003496)2.27993838
33Overlapping toe (HP:0001845)2.27314189
34Capillary hemangiomas (HP:0005306)2.27188906
35Acute hepatic failure (HP:0006554)2.26505470
36Abnormality of the ileum (HP:0001549)2.25732165
37Posterior subcapsular cataract (HP:0007787)2.24758514
38Methylmalonic acidemia (HP:0002912)2.24005595
39Recurrent bacterial skin infections (HP:0005406)2.20530789
40Abnormality of methionine metabolism (HP:0010901)2.19987732
41Panhypogammaglobulinemia (HP:0003139)2.19748707
42Ovarian neoplasm (HP:0100615)2.17375676
43Hypoproteinemia (HP:0003075)2.14962193
44Abnormality of eosinophils (HP:0001879)2.14606241
45Reticulocytopenia (HP:0001896)2.14439641
46Flat capital femoral epiphysis (HP:0003370)2.12587523
47Cortical dysplasia (HP:0002539)2.11586835
48Autoimmune hemolytic anemia (HP:0001890)2.09980136
49Colon cancer (HP:0003003)2.09930757
50Lip pit (HP:0100267)2.09608323
51Recurrent viral infections (HP:0004429)2.08533566
52Premature ovarian failure (HP:0008209)2.06373976
53Prominent nose (HP:0000448)2.06169851
54Chronic diarrhea (HP:0002028)2.06005914
55Duodenal stenosis (HP:0100867)2.04585908
56Small intestinal stenosis (HP:0012848)2.04585908
57Amaurosis fugax (HP:0100576)2.04376341
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04229994
59Prostate neoplasm (HP:0100787)2.03893021
60Neoplasm of the colon (HP:0100273)2.03057836
61Neoplasm of the small intestine (HP:0100833)2.02629929
62Disinhibition (HP:0000734)2.00107346
63Neoplasm of the pancreas (HP:0002894)1.99457019
64Abnormality of the musculature of the pelvis (HP:0001469)1.98813613
65Abnormality of the hip-girdle musculature (HP:0001445)1.98813613
66Leukocytosis (HP:0001974)1.98648152
67Abnormality of the labia minora (HP:0012880)1.98633326
68Thrombocytosis (HP:0001894)1.98404850
69Lymphoma (HP:0002665)1.97949663
70T lymphocytopenia (HP:0005403)1.97754576
71Abnormal lung lobation (HP:0002101)1.97534032
72Pelvic girdle muscle weakness (HP:0003749)1.97384051
73Medulloblastoma (HP:0002885)1.97051682
74Microretrognathia (HP:0000308)1.96471961
75Sparse lateral eyebrow (HP:0005338)1.96295759
76Pancreatic islet-cell hyperplasia (HP:0004510)1.96276049
77Abnormality of T cells (HP:0002843)1.96226799
78Postnatal microcephaly (HP:0005484)1.96001879
79Biliary tract neoplasm (HP:0100574)1.95368497
80Secondary amenorrhea (HP:0000869)1.93964220
81Abnormality of DNA repair (HP:0003254)1.92653901
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92619409
83Abnormal protein N-linked glycosylation (HP:0012347)1.92619409
84Abnormal protein glycosylation (HP:0012346)1.92619409
85Abnormal glycosylation (HP:0012345)1.92619409
86Encephalitis (HP:0002383)1.92174257
87Sandal gap (HP:0001852)1.91474592
88Clubbing of toes (HP:0100760)1.90617343
89Abnormal spermatogenesis (HP:0008669)1.90576420
90Hematochezia (HP:0002573)1.89710194
91Combined immunodeficiency (HP:0005387)1.89341351
92Abnormality of T cell number (HP:0011839)1.89268167
93Premature graying of hair (HP:0002216)1.89236736
94Myositis (HP:0100614)1.88256378
95High pitched voice (HP:0001620)1.87865983
96Aseptic necrosis (HP:0010885)1.87532976
97Pulmonary fibrosis (HP:0002206)1.87215846
98Rhabdomyosarcoma (HP:0002859)1.86998222
99Bone marrow hypocellularity (HP:0005528)1.86938687
100Abnormality of T cell physiology (HP:0011840)1.86254431
101Blepharitis (HP:0000498)1.85687364
102Selective tooth agenesis (HP:0001592)1.84263403
103Absent radius (HP:0003974)1.83305196
104Rough bone trabeculation (HP:0100670)1.83092333
105Abnormal hair whorl (HP:0010721)1.81856700
106Slender long bone (HP:0003100)1.80526341
107Eczematoid dermatitis (HP:0000976)1.80481661
108Keratoconjunctivitis sicca (HP:0001097)1.80379097
109Abnormality of serum amino acid levels (HP:0003112)1.79958634
110Cellular immunodeficiency (HP:0005374)1.79930125
111Spondylolisthesis (HP:0003302)1.79108983
112Exercise-induced muscle cramps (HP:0003710)1.78542951
113Volvulus (HP:0002580)1.78517332
114Facial diplegia (HP:0001349)1.77771615
115Recurrent fungal infections (HP:0002841)1.77626892
116Sloping forehead (HP:0000340)1.77248681
117Neoplasm of the rectum (HP:0100743)1.76463848
118Cafe-au-lait spot (HP:0000957)1.76183632
119Microvesicular hepatic steatosis (HP:0001414)1.75931974
120Multiple enchondromatosis (HP:0005701)1.75754858
121Neoplasm of the adrenal gland (HP:0100631)1.75577708
122Deep philtrum (HP:0002002)1.75501376
123Long clavicles (HP:0000890)1.74608104
124Entropion (HP:0000621)1.74566035
125Broad palm (HP:0001169)1.74114268
126Abnormal biliary tract morphology (HP:0012440)1.73846659
127Basal cell carcinoma (HP:0002671)1.73184981
128Granulocytopenia (HP:0001913)1.72795884
129Abnormality of the vitamin B12 metabolism (HP:0004341)1.71684222
130Severe combined immunodeficiency (HP:0004430)1.71678075
131Urticaria (HP:0001025)1.71653994
132Erythroderma (HP:0001019)1.69416463
133Agnosia (HP:0010524)1.69093099
134Retrobulbar optic neuritis (HP:0100654)1.68884517
135Optic neuritis (HP:0100653)1.68884517
136Short 4th metacarpal (HP:0010044)1.68881237
137Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68881237
138Median cleft lip (HP:0000161)1.68645244
139IgA deficiency (HP:0002720)1.68614432
140Autoimmune thrombocytopenia (HP:0001973)1.68499367
141Leukopenia (HP:0001882)1.68414825
142Abnormality of the anterior horn cell (HP:0006802)1.68120704
143Degeneration of anterior horn cells (HP:0002398)1.68120704
144Malignant gastrointestinal tract tumors (HP:0006749)1.67918014
145Gastrointestinal carcinoma (HP:0002672)1.67918014
146Bicuspid aortic valve (HP:0001647)1.67275232
147Osteomyelitis (HP:0002754)1.67008154
148Hypochromic microcytic anemia (HP:0004840)1.67005965
149Aplasia involving forearm bones (HP:0009822)1.66889146
150Absent forearm bone (HP:0003953)1.66889146
151Ankle contracture (HP:0006466)1.66343129
152Absent thumb (HP:0009777)1.66330697
153Recurrent abscess formation (HP:0002722)1.66236299
154Abnormality of the prostate (HP:0008775)1.66152219
155Abnormality of the carotid arteries (HP:0005344)1.66084466
156Long eyelashes (HP:0000527)1.65848474
157Type I transferrin isoform profile (HP:0003642)1.65729990
158Increased density of long bones (HP:0006392)1.65462179
159Abnormality of the calcaneus (HP:0008364)1.65431942
160Eosinophilia (HP:0001880)1.65419609
161Curly hair (HP:0002212)1.64991979
162IgG deficiency (HP:0004315)1.64388710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.55844665
2CDC73.55488901
3BCR3.31374604
4PLK43.25363762
5MST43.21933269
6SIK33.10830895
7ACVR1B2.93055765
8BUB12.56497959
9EIF2AK12.51621722
10ERBB32.48125708
11RPS6KA42.46347758
12LATS12.39369242
13WEE12.38071466
14STK102.32574708
15TTK2.27957394
16NEK22.26283688
17MAP4K22.08979882
18TSSK62.02604966
19BRSK22.00411490
20CDK191.95790612
21EEF2K1.95294078
22MAPKAPK31.80721937
23BMPR21.76979592
24JAK31.71226992
25SRPK11.64391287
26TAOK31.63871391
27IRAK31.62514797
28PBK1.61577763
29DYRK31.60163793
30SCYL21.53572880
31MAP3K81.52453352
32PLK11.51807081
33EIF2AK31.51556939
34RPS6KB21.51242153
35STK31.49745824
36BRD41.47258144
37AURKB1.42668708
38WNK31.37850987
39MELK1.34717266
40TESK21.34038676
41ATR1.32867002
42MAP4K11.32078009
43RAF11.27755655
44CHEK21.23771368
45NEK91.16264710
46MAP3K61.15426557
47ZAK1.15357076
48TGFBR11.14908488
49CDK121.14398330
50KDR1.12823890
51TYK21.12531535
52FLT31.12262956
53KSR21.11625754
54MAP3K131.10280959
55CDK81.08953349
56NUAK11.07440920
57LATS21.05566443
58NLK1.01694473
59FRK1.01411024
60CDK91.00749461
61CDK41.00460509
62EPHA20.97977694
63VRK10.97529735
64PLK30.96615979
65TEC0.93879117
66BCKDK0.92184208
67STK38L0.91565178
68MAP3K120.90792969
69TXK0.90229968
70ZAP700.89188573
71MAP3K40.88979214
72ERBB40.88370517
73TAOK10.87342392
74BRAF0.86460045
75CDK70.86055837
76NEK10.85605033
77LRRK20.85022492
78FGR0.84339446
79ATM0.83557045
80CHEK10.82741208
81CSNK1G10.81753170
82CDK60.81174373
83BRSK10.80095046
84PASK0.79452005
85PIM10.77914187
86CSNK1G30.77740327
87MAP3K30.75854140
88CSNK1A1L0.75090268
89MAP3K50.74861016
90RIPK40.73706164
91STK40.73040893
92ITK0.70972559
93BMPR1B0.70580361
94EGFR0.69201875
95CHUK0.68380606
96IRAK40.67110004
97YES10.66921986
98CLK10.66034583
99AURKA0.63953961
100CSK0.62256473
101PKN20.61092698
102AKT30.60438251
103TNIK0.60015955
104EPHA30.59621414
105MAP3K100.59515575
106CSNK1G20.59393540
107MARK30.57747876
108FES0.57475219
109FGFR30.56773850
110MKNK10.55775050
111MAP2K70.54828548
112TRPM70.54742994
113BTK0.54162254
114EIF2AK20.53489188
115STK240.53118038
116LCK0.52939341
117MKNK20.52860645
118GRK60.52624640
119HCK0.52162449
120IRAK10.52104449
121PIK3CG0.50550475
122MATK0.50006031
123JAK20.49384244
124OXSR10.49372526
125MOS0.49165547
126STK160.49162572
127LYN0.48943130
128CDK20.48598679
129RPS6KA50.48238370
130PAK40.48088288
131NEK60.47940847
132KIT0.47292654
133KSR10.47190048
134PLK20.46929177
135MAP2K30.46397949
136SYK0.45607420
137TBK10.44239905
138MAP3K140.43722347
139IKBKE0.43112699
140JAK10.42019543
141TAOK20.41680851
142TESK10.41548852
143TLK10.41235587
144MAPK110.38914095
145HIPK20.36906337
146CAMKK20.36457506

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.42964717
2Cell cycle_Homo sapiens_hsa041103.21840748
3Mismatch repair_Homo sapiens_hsa034302.74974629
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58095525
5RNA transport_Homo sapiens_hsa030132.42954655
6Homologous recombination_Homo sapiens_hsa034402.30691146
7RNA degradation_Homo sapiens_hsa030182.28055857
8p53 signaling pathway_Homo sapiens_hsa041152.25288281
9Base excision repair_Homo sapiens_hsa034102.22806466
10Non-homologous end-joining_Homo sapiens_hsa034502.17779041
11Nucleotide excision repair_Homo sapiens_hsa034202.06760713
12Spliceosome_Homo sapiens_hsa030402.06742830
13Fanconi anemia pathway_Homo sapiens_hsa034602.06317102
14Allograft rejection_Homo sapiens_hsa053301.92627176
15Basal transcription factors_Homo sapiens_hsa030221.86637086
16Autoimmune thyroid disease_Homo sapiens_hsa053201.84110401
17One carbon pool by folate_Homo sapiens_hsa006701.82838204
18RNA polymerase_Homo sapiens_hsa030201.78584765
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65567654
20Propanoate metabolism_Homo sapiens_hsa006401.59204903
21Herpes simplex infection_Homo sapiens_hsa051681.54902527
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54589450
23Pyrimidine metabolism_Homo sapiens_hsa002401.53754566
24Antigen processing and presentation_Homo sapiens_hsa046121.49667526
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46544983
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.45699224
27Steroid biosynthesis_Homo sapiens_hsa001001.45344601
28Asthma_Homo sapiens_hsa053101.42865796
29Type I diabetes mellitus_Homo sapiens_hsa049401.39171574
30mRNA surveillance pathway_Homo sapiens_hsa030151.36923940
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.34878856
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34024785
33Epstein-Barr virus infection_Homo sapiens_hsa051691.28754797
34Viral carcinogenesis_Homo sapiens_hsa052031.27640272
35Primary immunodeficiency_Homo sapiens_hsa053401.27602538
36Pancreatic cancer_Homo sapiens_hsa052121.24570053
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23500189
38Measles_Homo sapiens_hsa051621.22693858
39HTLV-I infection_Homo sapiens_hsa051661.20761891
40MicroRNAs in cancer_Homo sapiens_hsa052061.20563178
41Proteasome_Homo sapiens_hsa030501.19462152
42Small cell lung cancer_Homo sapiens_hsa052221.17482644
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16066926
44TGF-beta signaling pathway_Homo sapiens_hsa043501.15185901
45Regulation of autophagy_Homo sapiens_hsa041401.14196405
46Hepatitis B_Homo sapiens_hsa051611.12992266
47Legionellosis_Homo sapiens_hsa051341.12511838
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11357737
49* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08900160
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08134917
51Oocyte meiosis_Homo sapiens_hsa041141.04315624
52Shigellosis_Homo sapiens_hsa051311.02405799
53Apoptosis_Homo sapiens_hsa042101.00783318
54Leishmaniasis_Homo sapiens_hsa051401.00537085
55Chronic myeloid leukemia_Homo sapiens_hsa052201.00401033
56Systemic lupus erythematosus_Homo sapiens_hsa053220.98012356
57Influenza A_Homo sapiens_hsa051640.97132667
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96504160
59Colorectal cancer_Homo sapiens_hsa052100.96295627
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94437582
61Thyroid cancer_Homo sapiens_hsa052160.94358432
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94268881
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92186238
64Fatty acid elongation_Homo sapiens_hsa000620.91791809
65* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91772955
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.91454426
67Adherens junction_Homo sapiens_hsa045200.89891511
68TNF signaling pathway_Homo sapiens_hsa046680.89530750
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88889718
70Hematopoietic cell lineage_Homo sapiens_hsa046400.86811311
71Toxoplasmosis_Homo sapiens_hsa051450.82622221
72T cell receptor signaling pathway_Homo sapiens_hsa046600.81651314
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81328350
74Selenocompound metabolism_Homo sapiens_hsa004500.81006262
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78129537
76Rheumatoid arthritis_Homo sapiens_hsa053230.76931754
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.76767247
78Circadian rhythm_Homo sapiens_hsa047100.74830786
79Viral myocarditis_Homo sapiens_hsa054160.73901885
80Osteoclast differentiation_Homo sapiens_hsa043800.73830005
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71213078
82B cell receptor signaling pathway_Homo sapiens_hsa046620.70902752
83Prolactin signaling pathway_Homo sapiens_hsa049170.70788911
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69929804
85Acute myeloid leukemia_Homo sapiens_hsa052210.69887068
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68646344
87Purine metabolism_Homo sapiens_hsa002300.68014713
88FoxO signaling pathway_Homo sapiens_hsa040680.67074923
89Salmonella infection_Homo sapiens_hsa051320.66444450
90Ribosome_Homo sapiens_hsa030100.65839069
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65819418
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64976198
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64131937
94mTOR signaling pathway_Homo sapiens_hsa041500.63810579
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.61613389
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61222376
97Bladder cancer_Homo sapiens_hsa052190.57173982
98Protein export_Homo sapiens_hsa030600.56298383
99Prostate cancer_Homo sapiens_hsa052150.55977749
100Malaria_Homo sapiens_hsa051440.53363716
101Notch signaling pathway_Homo sapiens_hsa043300.53016738
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52412405
103Folate biosynthesis_Homo sapiens_hsa007900.50501023
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.49995918
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47176408
106Carbon metabolism_Homo sapiens_hsa012000.47104081
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45838904
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45693279
109Hippo signaling pathway_Homo sapiens_hsa043900.44344919
110Chemokine signaling pathway_Homo sapiens_hsa040620.43082156
111Pentose phosphate pathway_Homo sapiens_hsa000300.42997220
112Lysine degradation_Homo sapiens_hsa003100.42843088
113Tuberculosis_Homo sapiens_hsa051520.41727744
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40365113
115Hepatitis C_Homo sapiens_hsa051600.40341827
116Pathways in cancer_Homo sapiens_hsa052000.40010232
117Vitamin B6 metabolism_Homo sapiens_hsa007500.39832525
118HIF-1 signaling pathway_Homo sapiens_hsa040660.39223744
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38949960
120Proteoglycans in cancer_Homo sapiens_hsa052050.38124336
121Caffeine metabolism_Homo sapiens_hsa002320.37785605
122Endometrial cancer_Homo sapiens_hsa052130.37680266
123VEGF signaling pathway_Homo sapiens_hsa043700.37395068
124Graft-versus-host disease_Homo sapiens_hsa053320.36131508
125Other glycan degradation_Homo sapiens_hsa005110.35782799
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34788622
127Biosynthesis of amino acids_Homo sapiens_hsa012300.34464393
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33914211
129Pyruvate metabolism_Homo sapiens_hsa006200.29462165
130Sulfur metabolism_Homo sapiens_hsa009200.29412361
131Glutathione metabolism_Homo sapiens_hsa004800.28632895
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28587717
133Pertussis_Homo sapiens_hsa051330.27496210
134Phagosome_Homo sapiens_hsa041450.26802753

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