UBE2D3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.91697865
2DNA deamination (GO:0045006)7.68803437
3signal peptide processing (GO:0006465)6.24799651
4regulation of translational termination (GO:0006449)5.40358266
5cytidine metabolic process (GO:0046087)5.29727936
6cytidine catabolic process (GO:0006216)5.29727936
7cytidine deamination (GO:0009972)5.29727936
8sphingosine metabolic process (GO:0006670)5.20330600
9diol metabolic process (GO:0034311)4.71986585
10regulation of immunoglobulin secretion (GO:0051023)4.60720045
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.34754047
12lipopolysaccharide biosynthetic process (GO:0009103)4.28551444
13sphingoid metabolic process (GO:0046519)4.26399834
14regulation of cytokine production involved in inflammatory response (GO:1900015)4.24564970
15regulation of interleukin-12 biosynthetic process (GO:0045075)4.00605117
16negative regulation of T-helper cell differentiation (GO:0045623)3.99857922
17negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.99857922
18proteasome assembly (GO:0043248)3.99025241
19negative regulation by host of viral transcription (GO:0043922)3.98617115
20regulation of meiosis I (GO:0060631)3.92207618
21lipopolysaccharide metabolic process (GO:0008653)3.73449411
22cytochrome complex assembly (GO:0017004)3.64236002
23positive regulation of defense response to virus by host (GO:0002230)3.60395567
24DNA methylation involved in gamete generation (GO:0043046)3.59930675
25ribonucleoprotein complex disassembly (GO:0032988)3.57563101
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52138502
27positive regulation of uterine smooth muscle contraction (GO:0070474)3.45628955
28tachykinin receptor signaling pathway (GO:0007217)3.43230386
29regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.41564396
30actin nucleation (GO:0045010)3.39863328
31adaptation of signaling pathway (GO:0023058)3.38817454
32sequestering of actin monomers (GO:0042989)3.37564825
33regulation of cellular amino acid metabolic process (GO:0006521)3.33156602
34regulation of chronic inflammatory response (GO:0002676)3.33065730
35negative regulation of glycoprotein biosynthetic process (GO:0010561)3.28053575
36sulfate transmembrane transport (GO:1902358)3.27924859
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.25345075
38cellular response to interleukin-15 (GO:0071350)3.25242186
39rRNA modification (GO:0000154)3.24966375
40piRNA metabolic process (GO:0034587)3.24004376
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22341588
42platelet dense granule organization (GO:0060155)3.22150061
43organelle disassembly (GO:1903008)3.21265951
44T-helper cell differentiation (GO:0042093)3.20890242
45CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.20890242
46respiratory chain complex IV assembly (GO:0008535)3.19880443
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18124921
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16553293
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16553293
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16553293
51DNA double-strand break processing (GO:0000729)3.14569685
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12013396
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12013396
54indole-containing compound catabolic process (GO:0042436)3.11372713
55indolalkylamine catabolic process (GO:0046218)3.11372713
56tryptophan catabolic process (GO:0006569)3.11372713
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09869042
58regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.04071017
59positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.03789339
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02682729
61regulation of isotype switching to IgG isotypes (GO:0048302)3.01228252
62sulfate transport (GO:0008272)3.00669792
63signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98760051
64signal transduction involved in DNA damage checkpoint (GO:0072422)2.98760051
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98062606
66terpenoid biosynthetic process (GO:0016114)2.97081472
67dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.95641118
68DNA demethylation (GO:0080111)2.94944000
69signal transduction involved in cell cycle checkpoint (GO:0072395)2.93739320
70cytokine biosynthetic process (GO:0042089)2.93244986
71negative regulation of ligase activity (GO:0051352)2.89007525
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89007525
73positive regulation of developmental pigmentation (GO:0048087)2.88359697
74negative regulation of stress fiber assembly (GO:0051497)2.87357133
75protein complex biogenesis (GO:0070271)2.86883787
76protein neddylation (GO:0045116)2.85510414
77protein-chromophore linkage (GO:0018298)2.83411563
78alpha-beta T cell differentiation involved in immune response (GO:0002293)2.83084937
79alpha-beta T cell activation involved in immune response (GO:0002287)2.83084937
80T cell differentiation involved in immune response (GO:0002292)2.83084937
81tyrosine metabolic process (GO:0006570)2.82557452
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80821161
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80596674
84negative regulation of alpha-beta T cell differentiation (GO:0046639)2.80084927
85gonadal mesoderm development (GO:0007506)2.78064015
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76654285
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76654285
88cornea development in camera-type eye (GO:0061303)2.76302590
89regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75187355
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73378340
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73353877
92regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.70588644
93heme transport (GO:0015886)2.70134054
94GTP biosynthetic process (GO:0006183)2.69176129
95rhodopsin mediated signaling pathway (GO:0016056)2.67660217
96response to interleukin-15 (GO:0070672)2.66859895
97cytolysis (GO:0019835)2.66355379
98amino acid salvage (GO:0043102)2.62495534
99L-methionine salvage (GO:0071267)2.62495534
100L-methionine biosynthetic process (GO:0071265)2.62495534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.17731890
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09192730
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.08528518
4ZNF274_21170338_ChIP-Seq_K562_Hela3.38454205
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.19786109
6IGF1R_20145208_ChIP-Seq_DFB_Human3.16558272
7VDR_22108803_ChIP-Seq_LS180_Human2.96520786
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.89630427
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.85373911
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81787460
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36602672
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.31191727
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.23262385
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.18455454
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11883592
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.05440939
17ELK1_19687146_ChIP-ChIP_HELA_Human1.97621106
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93007728
19TP53_22573176_ChIP-Seq_HFKS_Human1.88621378
20P300_19829295_ChIP-Seq_ESCs_Human1.83537829
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81369061
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79338748
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78098328
24VDR_23849224_ChIP-Seq_CD4+_Human1.77859664
25ER_23166858_ChIP-Seq_MCF-7_Human1.75597535
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73166115
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68731574
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.67186677
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65684835
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.58321137
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57469010
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57373431
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53385959
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45979981
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.44140945
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.42187657
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40755684
38NANOG_19829295_ChIP-Seq_ESCs_Human1.40640827
39SOX2_19829295_ChIP-Seq_ESCs_Human1.40640827
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40487031
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.37752499
42NCOR_22424771_ChIP-Seq_293T_Human1.36165874
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35828326
44FOXP3_21729870_ChIP-Seq_TREG_Human1.34608879
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32032371
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31721466
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.30915275
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30915275
49TAF15_26573619_Chip-Seq_HEK293_Human1.30698328
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30405934
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.30284791
52TCF4_22108803_ChIP-Seq_LS180_Human1.28519186
53FUS_26573619_Chip-Seq_HEK293_Human1.27531604
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27079850
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26298283
56CDX2_22108803_ChIP-Seq_LS180_Human1.25966594
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25892303
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25475440
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25254985
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25047448
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.24092569
62HOXB7_26014856_ChIP-Seq_BT474_Human1.23962339
63GATA3_26560356_Chip-Seq_TH2_Human1.22027442
64AR_20517297_ChIP-Seq_VCAP_Human1.18584067
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16668143
66HTT_18923047_ChIP-ChIP_STHdh_Human1.16051596
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.14609072
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12912785
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12415256
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12187559
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10595493
72MYC_18940864_ChIP-ChIP_HL60_Human1.10001278
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.09638699
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09583266
75BCAT_22108803_ChIP-Seq_LS180_Human1.09576245
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08814176
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08309792
78CBP_20019798_ChIP-Seq_JUKART_Human1.08309792
79GBX2_23144817_ChIP-Seq_PC3_Human1.07674891
80MYC_19829295_ChIP-Seq_ESCs_Human1.07237657
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06148447
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05428017
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.04435816
84AR_21572438_ChIP-Seq_LNCaP_Human1.04371155
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.02802577
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02721744
87TAF2_19829295_ChIP-Seq_ESCs_Human1.02210817
88MYB_26560356_Chip-Seq_TH2_Human1.01625294
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00734893
90P53_21459846_ChIP-Seq_SAOS-2_Human1.00637474
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99450562
92DCP1A_22483619_ChIP-Seq_HELA_Human0.98681723
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98125030
94NANOG_20526341_ChIP-Seq_ESCs_Human0.98012598
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95927992
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.95687714
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94488867
98EGR1_19032775_ChIP-ChIP_M12_Human0.93953249
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93802361
100ERG_20517297_ChIP-Seq_VCAP_Human0.93400272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.82205768
2MP0005171_absent_coat_pigmentation3.89256855
3MP0003045_fibrosis3.86258155
4MP0003136_yellow_coat_color3.62565821
5MP0002653_abnormal_ependyma_morphology3.41997761
6MP0004147_increased_porphyrin_level3.00194289
7MP0000569_abnormal_digit_pigmentation2.78062292
8MP0005671_abnormal_response_to2.63968009
9MP0003646_muscle_fatigue2.63457881
10MP0009697_abnormal_copulation2.63251975
11MP0002102_abnormal_ear_morphology2.55450034
12MP0008875_abnormal_xenobiotic_pharmacok2.38233495
13MP0004381_abnormal_hair_follicle2.29716735
14MP0001661_extended_life_span2.28618216
15MP0001835_abnormal_antigen_presentation2.20348312
16MP0005387_immune_system_phenotype2.19928540
17MP0001790_abnormal_immune_system2.19928540
18MP0006072_abnormal_retinal_apoptosis2.16034555
19MP0000749_muscle_degeneration2.15719917
20MP0009785_altered_susceptibility_to2.06474375
21MP0004145_abnormal_muscle_electrophysio2.05817237
22MP0008877_abnormal_DNA_methylation2.02968203
23MP0006082_CNS_inflammation1.95956323
24MP0000372_irregular_coat_pigmentation1.83694589
25MP0001873_stomach_inflammation1.72984499
26MP0002095_abnormal_skin_pigmentation1.68132527
27MP0002933_joint_inflammation1.66744862
28MP0002166_altered_tumor_susceptibility1.65987208
29MP0002138_abnormal_hepatobiliary_system1.64301495
30MP0003786_premature_aging1.62052726
31MP0002168_other_aberrant_phenotype1.53438000
32MP0003137_abnormal_impulse_conducting1.53255117
33MP0001501_abnormal_sleep_pattern1.50735277
34MP0002254_reproductive_system_inflammat1.50017912
35MP0008872_abnormal_physiological_respon1.49671787
36MP0005167_abnormal_blood-brain_barrier1.46516954
37MP0003195_calcinosis1.45524651
38MP0005187_abnormal_penis_morphology1.44199047
39MP0001800_abnormal_humoral_immune1.34127045
40MP0005253_abnormal_eye_physiology1.32574922
41MP0005085_abnormal_gallbladder_physiolo1.31491999
42MP0001348_abnormal_lacrimal_gland1.28145052
43MP0003879_abnormal_hair_cell1.27800822
44MP0002148_abnormal_hypersensitivity_rea1.27777929
45MP0002006_tumorigenesis1.27306180
46MP0005646_abnormal_pituitary_gland1.25127816
47MP0005174_abnormal_tail_pigmentation1.25051944
48MP0000427_abnormal_hair_cycle1.24382064
49MP0003890_abnormal_embryonic-extraembry1.22442190
50MP0001968_abnormal_touch/_nociception1.16226874
51MP0006054_spinal_hemorrhage1.12305174
52MP0002160_abnormal_reproductive_system1.12212289
53MP0000015_abnormal_ear_pigmentation1.08623040
54MP0002736_abnormal_nociception_after1.08570157
55MP0005551_abnormal_eye_electrophysiolog1.08336930
56MP0005025_abnormal_response_to1.06248970
57MP0002723_abnormal_immune_serum1.04709360
58MP0005083_abnormal_biliary_tract1.01730528
59MP0001529_abnormal_vocalization1.00450363
60MP0005636_abnormal_mineral_homeostasis0.98467049
61MP0003763_abnormal_thymus_physiology0.98264785
62MP0005000_abnormal_immune_tolerance0.95477144
63MP0010155_abnormal_intestine_physiology0.95378314
64MP0005395_other_phenotype0.94663298
65MP0005075_abnormal_melanosome_morpholog0.88090519
66MP0002452_abnormal_antigen_presenting0.87054877
67MP0002420_abnormal_adaptive_immunity0.86288065
68MP0001765_abnormal_ion_homeostasis0.85840222
69MP0006036_abnormal_mitochondrial_physio0.82105828
70MP0004130_abnormal_muscle_cell0.81786194
71MP0000685_abnormal_immune_system0.80648856
72MP0005389_reproductive_system_phenotype0.80471354
73MP0001819_abnormal_immune_cell0.79943900
74MP0002277_abnormal_respiratory_mucosa0.78507892
75MP0005310_abnormal_salivary_gland0.77881532
76MP0008995_early_reproductive_senescence0.77620197
77MP0003866_abnormal_defecation0.77046942
78MP0002269_muscular_atrophy0.74275521
79MP0005330_cardiomyopathy0.74079994
80MP0000747_muscle_weakness0.71576217
81MP0001845_abnormal_inflammatory_respons0.70267602
82MP0005365_abnormal_bile_salt0.70195862
83MP0002938_white_spotting0.69704967
84MP0003252_abnormal_bile_duct0.69702816
85MP0003436_decreased_susceptibility_to0.69614483
86MP0004043_abnormal_pH_regulation0.67810541
87MP0003011_delayed_dark_adaptation0.67580295
88MP0002405_respiratory_system_inflammati0.65325250
89MP0008469_abnormal_protein_level0.64609409
90MP0004484_altered_response_of0.63961366
91MP0001764_abnormal_homeostasis0.62485776
92MP0001485_abnormal_pinna_reflex0.62266675
93MP0003878_abnormal_ear_physiology0.61496399
94MP0005377_hearing/vestibular/ear_phenot0.61496399
95MP0005410_abnormal_fertilization0.61438216
96MP0005319_abnormal_enzyme/_coenzyme0.59673956
97MP0009840_abnormal_foam_cell0.59572302
98MP0001542_abnormal_bone_strength0.58050050
99MP0002735_abnormal_chemical_nociception0.57958403
100MP0002722_abnormal_immune_system0.56937029

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.06810125
2Pancreatic cysts (HP:0001737)3.78406316
3Stomatitis (HP:0010280)3.76829421
4Abolished electroretinogram (ERG) (HP:0000550)3.41667016
5IgG deficiency (HP:0004315)3.41403191
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.38353986
7Increased IgM level (HP:0003496)3.35009522
8Type 2 muscle fiber atrophy (HP:0003554)3.32369141
9Parakeratosis (HP:0001036)3.28662052
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21933567
11Amelogenesis imperfecta (HP:0000705)3.18812758
12Mitochondrial inheritance (HP:0001427)3.10136996
13Autoimmune hemolytic anemia (HP:0001890)2.99200624
14Chronic diarrhea (HP:0002028)2.97709138
15Increased hepatocellular lipid droplets (HP:0006565)2.96976291
16Chronic hepatic failure (HP:0100626)2.91770621
17Muscle fiber atrophy (HP:0100295)2.89625455
18Increased CSF lactate (HP:0002490)2.87427468
19Severe visual impairment (HP:0001141)2.86260053
20Pancreatic fibrosis (HP:0100732)2.79976323
21Generalized aminoaciduria (HP:0002909)2.78398861
22Hematochezia (HP:0002573)2.71853583
23Lipid accumulation in hepatocytes (HP:0006561)2.71816915
243-Methylglutaconic aciduria (HP:0003535)2.70140497
25Congenital stationary night blindness (HP:0007642)2.69898707
26Pigmentary retinal degeneration (HP:0001146)2.69545297
27Progressive inability to walk (HP:0002505)2.66324439
28Colon cancer (HP:0003003)2.65698172
29Pendular nystagmus (HP:0012043)2.63694800
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63437852
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63437852
32Autoimmune thrombocytopenia (HP:0001973)2.61880168
33True hermaphroditism (HP:0010459)2.60398043
34Abnormality of the renal cortex (HP:0011035)2.58363207
35Acute necrotizing encephalopathy (HP:0006965)2.58192658
36Congenital, generalized hypertrichosis (HP:0004540)2.53518395
37Hypoalbuminemia (HP:0003073)2.53270530
38Abnormal albumin level (HP:0012116)2.53270530
39Acute encephalopathy (HP:0006846)2.47545657
40IgA deficiency (HP:0002720)2.45208227
41Renal Fanconi syndrome (HP:0001994)2.44056848
42Macular degeneration (HP:0000608)2.43178799
43Acute hepatic failure (HP:0006554)2.42715714
44Abnormal rod and cone electroretinograms (HP:0008323)2.42065301
45Albinism (HP:0001022)2.41583058
46Methylmalonic aciduria (HP:0012120)2.40247381
47Hepatic necrosis (HP:0002605)2.38464323
48Abnormality of T cells (HP:0002843)2.35990888
49Methylmalonic acidemia (HP:0002912)2.35393418
50Exertional dyspnea (HP:0002875)2.32259396
51Chorioretinal atrophy (HP:0000533)2.29539960
52Hepatocellular necrosis (HP:0001404)2.27699208
53Abnormality of T cell physiology (HP:0011840)2.27640437
54Focal motor seizures (HP:0011153)2.27574523
55Agitation (HP:0000713)2.26237129
56Progressive macrocephaly (HP:0004481)2.24297483
57Polydipsia (HP:0001959)2.23600096
58Abnormal drinking behavior (HP:0030082)2.23600096
59Abnormality of macular pigmentation (HP:0008002)2.23290279
60Increased intramyocellular lipid droplets (HP:0012240)2.21004693
61Type I transferrin isoform profile (HP:0003642)2.20711121
62Flat capital femoral epiphysis (HP:0003370)2.19352891
63Decreased circulating renin level (HP:0003351)2.18561315
64Cheilitis (HP:0100825)2.16849846
65Abnormal mitochondria in muscle tissue (HP:0008316)2.16681170
66Pancytopenia (HP:0001876)2.15685208
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.11945713
68Glycosuria (HP:0003076)2.11369910
69Abnormality of urine glucose concentration (HP:0011016)2.11369910
70Increased serum lactate (HP:0002151)2.10848600
71Hemoptysis (HP:0002105)2.09317731
72Erythroderma (HP:0001019)2.08053342
73Nephronophthisis (HP:0000090)2.06963763
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.03378207
75Gangrene (HP:0100758)1.99909907
76Hypothermia (HP:0002045)1.99476503
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96223741
78Abnormality of T cell number (HP:0011839)1.94670724
79Congenital ichthyosiform erythroderma (HP:0007431)1.93807369
80Mesomelia (HP:0003027)1.93645210
81Lactic acidosis (HP:0003128)1.89792232
82T lymphocytopenia (HP:0005403)1.87965166
83Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85972049
84Cystic liver disease (HP:0006706)1.85913623
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.85271497
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84400434
87Abnormality of the renal medulla (HP:0100957)1.84342107
88IgM deficiency (HP:0002850)1.83142545
89Decreased central vision (HP:0007663)1.81827310
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.80965724
91Acanthocytosis (HP:0001927)1.80032347
92Renal cortical cysts (HP:0000803)1.79122901
93Hypoplasia of the pons (HP:0012110)1.78605251
94Lethargy (HP:0001254)1.77332038
95Gaze-evoked nystagmus (HP:0000640)1.77254298
96Hypoproteinemia (HP:0003075)1.77042474
97Increased muscle lipid content (HP:0009058)1.76473121
98Submucous cleft hard palate (HP:0000176)1.76195333
99Molar tooth sign on MRI (HP:0002419)1.75274314
100Abnormality of midbrain morphology (HP:0002418)1.75274314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.37730029
2LATS14.20387066
3STK38L3.75478711
4EIF2AK33.36493397
5TXK3.25512552
6BCKDK3.20170075
7FRK2.57829926
8KDR2.42391465
9TIE12.30747934
10ADRBK22.20220293
11LATS22.16848945
12WNK42.13340238
13NME11.99159204
14ACVR1B1.95541255
15MST41.87390660
16EIF2AK11.83354644
17TAOK31.73886998
18DAPK21.72138223
19FER1.70544132
20PRKD31.70359315
21MAP3K121.62987233
22ZAK1.61981634
23NEK11.59332543
24GRK11.58762745
25VRK21.54076997
26TLK11.43810312
27GRK71.39840282
28TESK21.39283664
29AKT31.39160083
30ITK1.38018370
31MAPKAPK31.37762038
32LIMK11.36401024
33MELK1.34732864
34VRK11.23094135
35BRSK21.19679244
36NLK1.17970481
37OXSR11.16961586
38NUAK11.15908794
39PIK3CG1.11583008
40TESK11.08401694
41BUB11.05298031
42CLK11.03924946
43PAK31.02313121
44STK390.99373866
45TNK20.95044138
46PLK20.94242993
47CSNK1A1L0.88599720
48EPHA30.85605111
49INSRR0.84189696
50TRPM70.83091345
51MAP2K70.82844383
52WEE10.78528588
53STK30.73099236
54WNK30.71154385
55DAPK10.70488659
56BMPR20.69862843
57MYLK0.68013252
58IKBKB0.63124833
59EIF2AK20.62596346
60TRIM280.62098767
61BMPR1B0.61736271
62PHKG10.60926936
63PHKG20.60926936
64PRKCI0.60521670
65TYK20.58907235
66NEK20.56838464
67GRK50.55818959
68WNK10.55415056
69MAPKAPK50.54609622
70BRSK10.54550487
71SRPK10.53937551
72PLK30.51806568
73ADRBK10.49956932
74TGFBR20.49402420
75TAF10.48569492
76MAP3K40.47492466
77MKNK20.47391928
78STK380.46024243
79BCR0.45168111
80TEC0.44201853
81PRKAA20.43857350
82STK100.38861472
83CAMKK20.38565024
84MAP4K20.38367936
85PRKD10.38304953
86RPS6KA50.37961538
87FES0.37775011
88PRKCE0.37568410
89MAP2K20.36341509
90IKBKE0.35501526
91CSNK1G30.33867934
92TYRO30.33208070
93PIM10.32802846
94LCK0.31302409
95JAK30.28111526
96OBSCN0.27429930
97TBK10.26651482
98MAPKAPK20.25417653
99NEK60.23899264
100MAPK130.20782110

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.93871970
2Protein export_Homo sapiens_hsa030604.32021765
3Autoimmune thyroid disease_Homo sapiens_hsa053203.10292535
4Caffeine metabolism_Homo sapiens_hsa002322.99003928
5Phototransduction_Homo sapiens_hsa047442.85469643
6Oxidative phosphorylation_Homo sapiens_hsa001902.81899019
7Allograft rejection_Homo sapiens_hsa053302.57020743
8RNA polymerase_Homo sapiens_hsa030202.55090698
9Parkinsons disease_Homo sapiens_hsa050122.24731432
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20646742
11Asthma_Homo sapiens_hsa053102.19237118
12Primary immunodeficiency_Homo sapiens_hsa053402.06174865
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.96065306
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87543557
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83526238
16Alzheimers disease_Homo sapiens_hsa050101.75481738
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.65922758
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64219349
19Homologous recombination_Homo sapiens_hsa034401.49119815
20Huntingtons disease_Homo sapiens_hsa050161.46414345
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45549356
22Nitrogen metabolism_Homo sapiens_hsa009101.42624218
23Rheumatoid arthritis_Homo sapiens_hsa053231.38306734
24Graft-versus-host disease_Homo sapiens_hsa053321.35426459
25Basal transcription factors_Homo sapiens_hsa030221.29877143
26Sulfur metabolism_Homo sapiens_hsa009201.26870554
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21569414
28Selenocompound metabolism_Homo sapiens_hsa004501.20647011
29Phenylalanine metabolism_Homo sapiens_hsa003601.19136154
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18062725
31Hematopoietic cell lineage_Homo sapiens_hsa046401.17944401
32RNA degradation_Homo sapiens_hsa030181.15922584
33Antigen processing and presentation_Homo sapiens_hsa046121.14093689
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09944906
35Measles_Homo sapiens_hsa051621.08875789
36Fanconi anemia pathway_Homo sapiens_hsa034601.06547606
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06479010
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06002201
39Vitamin B6 metabolism_Homo sapiens_hsa007501.05848799
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02905900
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99439465
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94307089
43Cardiac muscle contraction_Homo sapiens_hsa042600.94271085
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93916715
45Linoleic acid metabolism_Homo sapiens_hsa005910.93901646
46Viral myocarditis_Homo sapiens_hsa054160.91862015
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91428437
48Pyrimidine metabolism_Homo sapiens_hsa002400.85872462
49Type I diabetes mellitus_Homo sapiens_hsa049400.84576250
50One carbon pool by folate_Homo sapiens_hsa006700.82372327
51Histidine metabolism_Homo sapiens_hsa003400.82249217
52Taste transduction_Homo sapiens_hsa047420.81955383
53Propanoate metabolism_Homo sapiens_hsa006400.81819127
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80460089
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79253537
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76835247
57N-Glycan biosynthesis_Homo sapiens_hsa005100.76662039
58Chemical carcinogenesis_Homo sapiens_hsa052040.74290821
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.74171974
60T cell receptor signaling pathway_Homo sapiens_hsa046600.73891660
61Tyrosine metabolism_Homo sapiens_hsa003500.73714361
62Nucleotide excision repair_Homo sapiens_hsa034200.71746402
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70809957
64Sphingolipid metabolism_Homo sapiens_hsa006000.70748936
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.69043916
66Tryptophan metabolism_Homo sapiens_hsa003800.66639319
67Purine metabolism_Homo sapiens_hsa002300.64685339
68Nicotine addiction_Homo sapiens_hsa050330.62704074
69Retinol metabolism_Homo sapiens_hsa008300.61216431
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.59943234
71DNA replication_Homo sapiens_hsa030300.56292551
72RNA transport_Homo sapiens_hsa030130.53379026
73Butanoate metabolism_Homo sapiens_hsa006500.52223290
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52057896
75Metabolic pathways_Homo sapiens_hsa011000.49185897
76Collecting duct acid secretion_Homo sapiens_hsa049660.49131489
77Arachidonic acid metabolism_Homo sapiens_hsa005900.48171577
78Mismatch repair_Homo sapiens_hsa034300.46440764
79beta-Alanine metabolism_Homo sapiens_hsa004100.45650129
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44967150
81TGF-beta signaling pathway_Homo sapiens_hsa043500.43810416
82Fructose and mannose metabolism_Homo sapiens_hsa000510.42114563
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41885142
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.41597817
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40056744
86Salivary secretion_Homo sapiens_hsa049700.39384947
87Calcium signaling pathway_Homo sapiens_hsa040200.39074911
88Malaria_Homo sapiens_hsa051440.38107676
89Peroxisome_Homo sapiens_hsa041460.38012176
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.37830663
91Epstein-Barr virus infection_Homo sapiens_hsa051690.37145162
92Mineral absorption_Homo sapiens_hsa049780.36198297
93Glutathione metabolism_Homo sapiens_hsa004800.35293219
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.35172939
95Ovarian steroidogenesis_Homo sapiens_hsa049130.32593472
96Spliceosome_Homo sapiens_hsa030400.30632005
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30390155
98Folate biosynthesis_Homo sapiens_hsa007900.30383909
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29292623
100Olfactory transduction_Homo sapiens_hsa047400.22191325

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