ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	4.93125881
2	protein complex biogenesis (GO:0070271)	4.31661214
3	behavioral response to nicotine (GO:0035095)	4.07071084
4	NADH dehydrogenase complex assembly (GO:0010257)	3.93854712
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.93854712
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.93854712
7	respiratory chain complex IV assembly (GO:0008535)	3.89474956
8	mitochondrial respiratory chain complex assembly (GO:0033108)	3.82294365
9	cytochrome complex assembly (GO:0017004)	3.72866191
10	cellular ketone body metabolic process (GO:0046950)	3.63951055
11	regulation of hexokinase activity (GO:1903299)	3.59918997
12	regulation of glucokinase activity (GO:0033131)	3.59918997
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.30980627
14	ketone body metabolic process (GO:1902224)	3.29009985
15	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.28604682
16	inositol phosphate catabolic process (GO:0071545)	3.17962754
17	indole-containing compound catabolic process (GO:0042436)	3.14019652
18	indolalkylamine catabolic process (GO:0046218)	3.14019652
19	tryptophan catabolic process (GO:0006569)	3.14019652
20	kynurenine metabolic process (GO:0070189)	3.12923126
21	regulation of skeletal muscle contraction (GO:0014819)	3.12602737
22	response to pheromone (GO:0019236)	3.08753249
23	nitric oxide mediated signal transduction (GO:0007263)	3.07198745
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.01743507
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.00514156
26	platelet dense granule organization (GO:0060155)	2.96695436
27	neuronal action potential propagation (GO:0019227)	2.96182211
28	dopamine transport (GO:0015872)	2.92004477
29	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.89518707
30	regulation of neurotransmitter uptake (GO:0051580)	2.88036694
31	indolalkylamine metabolic process (GO:0006586)	2.87915688
32	axoneme assembly (GO:0035082)	2.85598752
33	detection of light stimulus involved in visual perception (GO:0050908)	2.83885195
34	detection of light stimulus involved in sensory perception (GO:0050962)	2.83885195
35	DNA deamination (GO:0045006)	2.83313682
36	auditory receptor cell stereocilium organization (GO:0060088)	2.81250408
37	xenobiotic catabolic process (GO:0042178)	2.80603486
38	ubiquinone biosynthetic process (GO:0006744)	2.79784835
39	synaptic transmission, cholinergic (GO:0007271)	2.79522886
40	positive regulation of meiosis (GO:0045836)	2.77145491
41	branched-chain amino acid catabolic process (GO:0009083)	2.76863560
42	inositol phosphate dephosphorylation (GO:0046855)	2.72041846
43	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.72041846
44	aromatic amino acid family catabolic process (GO:0009074)	2.69553542
45	regulation of relaxation of muscle (GO:1901077)	2.68104090
46	glycerophospholipid catabolic process (GO:0046475)	2.67114766
47	muscle filament sliding (GO:0030049)	2.62770870
48	actin-myosin filament sliding (GO:0033275)	2.62770870
49	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.61445007
50	C4-dicarboxylate transport (GO:0015740)	2.61032729
51	electron transport chain (GO:0022900)	2.61010958
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.60673846
53	respiratory electron transport chain (GO:0022904)	2.58773259
54	neuronal action potential (GO:0019228)	2.58574597
55	benzene-containing compound metabolic process (GO:0042537)	2.58492992
56	dentate gyrus development (GO:0021542)	2.58159631
57	proline transport (GO:0015824)	2.57550047
58	calcium ion import (GO:0070509)	2.57355089
59	protein polyglutamylation (GO:0018095)	2.57236142
60	ubiquinone metabolic process (GO:0006743)	2.56077843
61	alanine transport (GO:0032328)	2.55669107
62	mannosylation (GO:0097502)	2.55277891
63	tryptophan metabolic process (GO:0006568)	2.55227484
64	positive regulation of meiotic cell cycle (GO:0051446)	2.53904067
65	cellular biogenic amine catabolic process (GO:0042402)	2.52564702
66	amine catabolic process (GO:0009310)	2.52564702
67	piRNA metabolic process (GO:0034587)	2.51150514
68	positive regulation of mitochondrial fission (GO:0090141)	2.47450956
69	startle response (GO:0001964)	2.47080294
70	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.45961667
71	L-methionine salvage (GO:0071267)	2.45901754
72	L-methionine biosynthetic process (GO:0071265)	2.45901754
73	amino acid salvage (GO:0043102)	2.45901754
74	nonmotile primary cilium assembly (GO:0035058)	2.45311640
75	GPI anchor metabolic process (GO:0006505)	2.44151760
76	cullin deneddylation (GO:0010388)	2.43678825
77	polyol catabolic process (GO:0046174)	2.41491904
78	adenosine metabolic process (GO:0046085)	2.41313460
79	fucose catabolic process (GO:0019317)	2.41189859
80	L-fucose metabolic process (GO:0042354)	2.41189859
81	L-fucose catabolic process (GO:0042355)	2.41189859
82	gamma-aminobutyric acid transport (GO:0015812)	2.39003238
83	vitamin biosynthetic process (GO:0009110)	2.37353302
84	C-terminal protein amino acid modification (GO:0018410)	2.37020433
85	somite development (GO:0061053)	2.36890642
86	action potential (GO:0001508)	2.36103682
87	kidney morphogenesis (GO:0060993)	2.35299978
88	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.34693271
89	sulfation (GO:0051923)	2.34401984
90	indole-containing compound metabolic process (GO:0042430)	2.33654211
91	anterograde synaptic vesicle transport (GO:0048490)	2.33132547
92	aspartate family amino acid catabolic process (GO:0009068)	2.30515064
93	membrane depolarization during action potential (GO:0086010)	2.30509381
94	skeletal muscle contraction (GO:0003009)	2.30103960
95	regulation of sarcomere organization (GO:0060297)	2.30055058
96	S-adenosylmethionine metabolic process (GO:0046500)	2.29755705
97	protein localization to cilium (GO:0061512)	2.29469494
98	neuromuscular synaptic transmission (GO:0007274)	2.29253692
99	regulation of action potential (GO:0098900)	2.28912978
100	pyrimidine nucleobase catabolic process (GO:0006208)	2.28803819

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.21154258
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08431160
3	VDR_22108803_ChIP-Seq_LS180_Human	2.73657782
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.72139315
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70638867
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.56278981
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.52008378
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.49836908
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32864446
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21894658
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.10727817
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08856119
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04087269
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90771552
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79152288
16	FUS_26573619_Chip-Seq_HEK293_Human	1.74734682
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.73228386
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.73177423
19	P300_19829295_ChIP-Seq_ESCs_Human	1.72673921
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.71590683
21	EWS_26573619_Chip-Seq_HEK293_Human	1.66749628
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66603260
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63086992
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62568396
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61144646
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57752945
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.55608494
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55608494
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53991881
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.51080598
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.50808288
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.50101463
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.49415599
34	AR_25329375_ChIP-Seq_VCAP_Human	1.47748130
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43319532
36	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43319532
37	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.43050528
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.42941284
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42442802
40	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.42282971
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40646032
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39651453
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39258686
44	STAT3_23295773_ChIP-Seq_U87_Human	1.38764302
45	TCF4_23295773_ChIP-Seq_U87_Human	1.37970864
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37789104
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36617329
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36514806
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36188141
50	* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35535478
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33836952
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32783842
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32679766
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31057594
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29541914
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29175562
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27345955
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25366376
59	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.25195990
60	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.23000788
61	NCOR_22424771_ChIP-Seq_293T_Human	1.22365308
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21121717
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19389580
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.19377983
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18930026
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18703796
67	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16633662
68	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15032118
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14480828
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14480828
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13820579
72	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13777641
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13293024
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12418640
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12193511
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11257684
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09908458
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.09338029
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08222518
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07921186
81	AR_20517297_ChIP-Seq_VCAP_Human	1.07204562
82	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07111381
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06731288
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06687399
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05972155
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05525334
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05401680
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04587311
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03458874
90	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02366570
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02273426
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01831536
93	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01146454
94	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.01055165
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00793356
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00121418
97	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98996311
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98281915
99	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.98153189
100	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98021361

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.73547879
2	MP0003646_muscle_fatigue	3.73490472
3	MP0004145_abnormal_muscle_electrophysio	3.34085261
4	MP0003195_calcinosis	3.27559754
5	MP0005646_abnormal_pituitary_gland	2.41953177
6	MP0002876_abnormal_thyroid_physiology	2.38463224
7	MP0006072_abnormal_retinal_apoptosis	2.25752431
8	MP0005551_abnormal_eye_electrophysiolog	2.18855657
9	MP0008877_abnormal_DNA_methylation	2.07329093
10	MP0005645_abnormal_hypothalamus_physiol	2.04680838
11	MP0000372_irregular_coat_pigmentation	1.94523814
12	MP0003283_abnormal_digestive_organ	1.92277919
13	MP0008875_abnormal_xenobiotic_pharmacok	1.91122657
14	MP0009046_muscle_twitch	1.89061425
15	MP0009745_abnormal_behavioral_response	1.83466146
16	MP0002272_abnormal_nervous_system	1.82304569
17	MP0004215_abnormal_myocardial_fiber	1.81350303
18	MP0005253_abnormal_eye_physiology	1.79343281
19	MP0006036_abnormal_mitochondrial_physio	1.79218049
20	MP0004270_analgesia	1.79049224
21	MP0001984_abnormal_olfaction	1.78670374
22	MP0002638_abnormal_pupillary_reflex	1.74171950
23	MP0000749_muscle_degeneration	1.74136891
24	MP0001968_abnormal_touch/_nociception	1.69826645
25	MP0002102_abnormal_ear_morphology	1.63183859
26	MP0003787_abnormal_imprinting	1.60650446
27	MP0003880_abnormal_central_pattern	1.60359422
28	MP0004142_abnormal_muscle_tone	1.53802027
29	MP0001501_abnormal_sleep_pattern	1.53285767
30	MP0002909_abnormal_adrenal_gland	1.49996709
31	MP0006276_abnormal_autonomic_nervous	1.46679488
32	MP0002064_seizures	1.43522426
33	MP0004885_abnormal_endolymph	1.43002605
34	MP0003011_delayed_dark_adaptation	1.41150349
35	MP0000013_abnormal_adipose_tissue	1.38744125
36	MP0005379_endocrine/exocrine_gland_phen	1.38046900
37	MP0004036_abnormal_muscle_relaxation	1.35625091
38	MP0004043_abnormal_pH_regulation	1.35021315
39	MP0010386_abnormal_urinary_bladder	1.30910575
40	MP0001986_abnormal_taste_sensitivity	1.29532484
41	MP0002163_abnormal_gland_morphology	1.28782215
42	MP0001905_abnormal_dopamine_level	1.28252693
43	MP0008775_abnormal_heart_ventricle	1.26784747
44	MP0001485_abnormal_pinna_reflex	1.26761641
45	MP0001486_abnormal_startle_reflex	1.26551065
46	MP0002736_abnormal_nociception_after	1.25989163
47	MP0005332_abnormal_amino_acid	1.25969415
48	MP0002734_abnormal_mechanical_nocicepti	1.25787516
49	MP0004130_abnormal_muscle_cell	1.24531945
50	MP0008872_abnormal_physiological_respon	1.18776189
51	MP0009780_abnormal_chondrocyte_physiolo	1.17969353
52	MP0002938_white_spotting	1.17812894
53	MP0000631_abnormal_neuroendocrine_gland	1.17751299
54	MP0002572_abnormal_emotion/affect_behav	1.17728741
55	MP0005167_abnormal_blood-brain_barrier	1.16942551
56	MP0001970_abnormal_pain_threshold	1.13659638
57	MP0002229_neurodegeneration	1.12362739
58	MP0005620_abnormal_muscle_contractility	1.11847226
59	MP0002557_abnormal_social/conspecific_i	1.11710449
60	MP0003635_abnormal_synaptic_transmissio	1.09533564
61	MP0005084_abnormal_gallbladder_morpholo	1.08419592
62	MP0002160_abnormal_reproductive_system	1.07723775
63	MP0002106_abnormal_muscle_physiology	1.06948298
64	MP0003879_abnormal_hair_cell	1.06514591
65	MP0002234_abnormal_pharynx_morphology	1.05617950
66	MP0002733_abnormal_thermal_nociception	1.04840553
67	MP0002653_abnormal_ependyma_morphology	1.04193790
68	MP0005670_abnormal_white_adipose	1.03267147
69	MP0003137_abnormal_impulse_conducting	1.02571511
70	MP0005075_abnormal_melanosome_morpholog	1.01974202
71	MP0003122_maternal_imprinting	1.00890085
72	MP0004085_abnormal_heartbeat	1.00527423
73	MP0004084_abnormal_cardiac_muscle	0.99709548
74	MP0002693_abnormal_pancreas_physiology	0.99528356
75	MP0002067_abnormal_sensory_capabilities	0.99144105
76	MP0005386_behavior/neurological_phenoty	0.98886727
77	MP0004924_abnormal_behavior	0.98886727
78	MP0002735_abnormal_chemical_nociception	0.98010624
79	MP0000569_abnormal_digit_pigmentation	0.97940753
80	MP0000230_abnormal_systemic_arterial	0.95995750
81	MP0002063_abnormal_learning/memory/cond	0.93424939
82	MP0006292_abnormal_olfactory_placode	0.92543995
83	MP0001944_abnormal_pancreas_morphology	0.91235763
84	MP0002127_abnormal_cardiovascular_syste	0.90915009
85	MP0002138_abnormal_hepatobiliary_system	0.90700338
86	MP0005369_muscle_phenotype	0.89712894
87	MP0005389_reproductive_system_phenotype	0.89500177
88	MP0004133_heterotaxia	0.88379648
89	MP0001440_abnormal_grooming_behavior	0.87489038
90	MP0002332_abnormal_exercise_endurance	0.86033649
91	MP0010329_abnormal_lipoprotein_level	0.85387995
92	MP0002139_abnormal_hepatobiliary_system	0.84982101
93	MP0000751_myopathy	0.84578452
94	MP0003950_abnormal_plasma_membrane	0.83899605
95	MP0005174_abnormal_tail_pigmentation	0.83626509
96	MP0005423_abnormal_somatic_nervous	0.82546539
97	MP0002078_abnormal_glucose_homeostasis	0.81139125
98	MP0005266_abnormal_metabolism	0.79015836
99	MP0003252_abnormal_bile_duct	0.78133544
100	MP0003633_abnormal_nervous_system	0.77875878

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.39775593
2	Muscle fiber inclusion bodies (HP:0100299)	3.39186370
3	Hepatic necrosis (HP:0002605)	3.32294619
4	Nemaline bodies (HP:0003798)	3.30428978
5	Mitochondrial inheritance (HP:0001427)	3.24568677
6	Progressive macrocephaly (HP:0004481)	3.24202903
7	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.20780260
8	Hepatocellular necrosis (HP:0001404)	3.18798080
9	Pancreatic cysts (HP:0001737)	3.18417984
10	Muscle hypertrophy of the lower extremities (HP:0008968)	3.12857574
11	Abnormality of midbrain morphology (HP:0002418)	3.05189928
12	Molar tooth sign on MRI (HP:0002419)	3.05189928
13	Increased CSF lactate (HP:0002490)	3.04319419
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.01392577
15	Acute encephalopathy (HP:0006846)	3.01106172
16	Calf muscle hypertrophy (HP:0008981)	3.00381287
17	Ketoacidosis (HP:0001993)	2.96757896
18	Pancreatic fibrosis (HP:0100732)	2.93953154
19	True hermaphroditism (HP:0010459)	2.85057519
20	Abnormality of the renal cortex (HP:0011035)	2.82785187
21	Medial flaring of the eyebrow (HP:0010747)	2.81982903
22	Type 2 muscle fiber atrophy (HP:0003554)	2.81802954
23	Methylmalonic acidemia (HP:0002912)	2.78688330
24	Type II lissencephaly (HP:0007260)	2.77537932
25	Congenital stationary night blindness (HP:0007642)	2.73900877
26	Renal cortical cysts (HP:0000803)	2.70935556
27	Nephronophthisis (HP:0000090)	2.69594588
28	Ketosis (HP:0001946)	2.60271255
29	Hypomagnesemia (HP:0002917)	2.53940717
30	Hyperventilation (HP:0002883)	2.50775682
31	Congenital sensorineural hearing impairment (HP:0008527)	2.46805845
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.43185982
33	Methylmalonic aciduria (HP:0012120)	2.41788543
34	Respiratory failure (HP:0002878)	2.39832936
35	Large for gestational age (HP:0001520)	2.32243425
36	Hemiparesis (HP:0001269)	2.29986277
37	Abnormality of the renal medulla (HP:0100957)	2.29904474
38	Hypothermia (HP:0002045)	2.27163316
39	Abolished electroretinogram (ERG) (HP:0000550)	2.25115841
40	Cerebral edema (HP:0002181)	2.22674942
41	Attenuation of retinal blood vessels (HP:0007843)	2.20478945
42	Agitation (HP:0000713)	2.19179729
43	Muscle fiber atrophy (HP:0100295)	2.18745871
44	Pendular nystagmus (HP:0012043)	2.17100694
45	3-Methylglutaconic aciduria (HP:0003535)	2.15935980
46	Exercise-induced muscle cramps (HP:0003710)	2.13648133
47	Polydipsia (HP:0001959)	2.12193873
48	Abnormal drinking behavior (HP:0030082)	2.12193873
49	Gait imbalance (HP:0002141)	2.11007576
50	Lactic acidosis (HP:0003128)	2.10646583
51	Lipid accumulation in hepatocytes (HP:0006561)	2.06641786
52	Optic disc pallor (HP:0000543)	2.04969391
53	CNS demyelination (HP:0007305)	2.03906526
54	Bundle branch block (HP:0011710)	2.03629633
55	Polyuria (HP:0000103)	2.01607346
56	Hyperglycinuria (HP:0003108)	2.01426398
57	Congenital primary aphakia (HP:0007707)	1.99052650
58	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97053561
59	Lethargy (HP:0001254)	1.96074013
60	Abnormality of the calf musculature (HP:0001430)	1.95860004
61	Hypoglycemic coma (HP:0001325)	1.93886169
62	Increased serum lactate (HP:0002151)	1.93692746
63	Gaze-evoked nystagmus (HP:0000640)	1.92363719
64	Tachypnea (HP:0002789)	1.92138721
65	Absent phalangeal crease (HP:0006109)	1.91432662
66	Abnormality of magnesium homeostasis (HP:0004921)	1.90571747
67	Syncope (HP:0001279)	1.90385386
68	Increased hepatocellular lipid droplets (HP:0006565)	1.90177293
69	Abnormality of vitamin B metabolism (HP:0004340)	1.89887011
70	Insulin-resistant diabetes mellitus (HP:0000831)	1.89406351
71	Abnormality of alanine metabolism (HP:0010916)	1.88962596
72	Hyperalaninemia (HP:0003348)	1.88962596
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88962596
74	Progressive cerebellar ataxia (HP:0002073)	1.87472386
75	Hyperglycinemia (HP:0002154)	1.85388190
76	Abnormal EKG (HP:0003115)	1.83354348
77	Progressive inability to walk (HP:0002505)	1.82732379
78	Retinal dysplasia (HP:0007973)	1.82590267
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81560102
80	Exercise-induced myalgia (HP:0003738)	1.81055676
81	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.80428775
82	Dicarboxylic aciduria (HP:0003215)	1.80428775
83	Hypoplasia of the fovea (HP:0007750)	1.79975309
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.79975309
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.79782441
86	Abnormality of glycine metabolism (HP:0010895)	1.79782441
87	Left ventricular hypertrophy (HP:0001712)	1.78614949
88	Glycosuria (HP:0003076)	1.78524519
89	Abnormality of urine glucose concentration (HP:0011016)	1.78524519
90	Late onset (HP:0003584)	1.78029891
91	Inability to walk (HP:0002540)	1.77992685
92	Progressive microcephaly (HP:0000253)	1.76802069
93	Fetal akinesia sequence (HP:0001989)	1.76468405
94	Generalized aminoaciduria (HP:0002909)	1.75795469
95	Broad-based gait (HP:0002136)	1.75385113
96	Decreased central vision (HP:0007663)	1.73910411
97	Abnormality of macular pigmentation (HP:0008002)	1.73870448
98	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.73621938
99	Renal Fanconi syndrome (HP:0001994)	1.73051287
100	Oligomenorrhea (HP:0000876)	1.72902870

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.53802340
2	BMPR1B	4.13585623
3	OBSCN	3.52128281
4	PHKG2	3.28130866
5	PHKG1	3.28130866
6	PINK1	3.19166970
7	MAP4K2	2.60136211
8	WNK3	2.44047937
9	TAOK3	2.41813076
10	GRK1	2.30179596
11	ADRBK2	2.24008019
12	MAPK13	1.95420107
13	NUAK1	1.77373102
14	BCKDK	1.68875302
15	PLK2	1.52717631
16	MARK1	1.50897995
17	MUSK	1.48562243
18	MST4	1.44082919
19	PAK3	1.42139631
20	INSRR	1.38476022
21	NTRK3	1.36121651
22	DAPK2	1.33395389
23	OXSR1	1.33016816
24	STK39	1.28967874
25	MAP3K4	1.26345438
26	LIMK1	1.26142138
27	WNK4	1.19915126
28	ZAK	1.17902071
29	MAPKAPK3	1.10873991
30	VRK2	1.05468311
31	CASK	1.05375727
32	IRAK1	1.03708352
33	CSNK1G2	1.02815206
34	ERBB3	0.99704039
35	CSNK1G1	0.98102606
36	TLK1	0.97523576
37	FER	0.97376190
38	CSNK1G3	0.94720058
39	PRKCE	0.93719032
40	FGFR2	0.91612711
41	ACVR1B	0.90525948
42	MAP2K6	0.88048371
43	DYRK2	0.83652994
44	EIF2AK3	0.82390478
45	PIK3CG	0.81410204
46	PDK2	0.81125574
47	STK16	0.80367371
48	CAMK2D	0.79940767
49	PTK2B	0.78199701
50	MAP2K7	0.76764529
51	VRK1	0.74618175
52	CAMK2A	0.74222258
53	TXK	0.73950789
54	PIK3CA	0.73322911
55	CSNK1A1L	0.71706865
56	PRKCG	0.71690414
57	MAPKAPK5	0.68956108
58	PKN1	0.68399205
59	ADRBK1	0.66391890
60	STK38L	0.65990118
61	GRK7	0.61921777
62	PRKCI	0.61608911
63	PRKACA	0.61043565
64	TIE1	0.58086867
65	GRK5	0.55910847
66	CAMK1	0.55605416
67	TNIK	0.52852563
68	TRPM7	0.51417780
69	IKBKB	0.50400773
70	MARK3	0.50291359
71	TNK2	0.49715769
72	CSNK1A1	0.48135340
73	PRKAA1	0.46652208
74	PRKG1	0.45183589
75	CCNB1	0.44284643
76	PRKCQ	0.44110755
77	AKT3	0.43424620
78	NME1	0.43344838
79	PAK6	0.42228653
80	EPHA4	0.41545277
81	PASK	0.41482969
82	CAMK2G	0.41442934
83	PRKAA2	0.41150527
84	PRKD3	0.39956317
85	MAP2K1	0.39805938
86	DAPK1	0.39376240
87	PLK3	0.39367024
88	CSNK1D	0.39261385
89	PRKACB	0.38496120
90	STK11	0.37402721
91	PRKD2	0.35735414
92	PRKCA	0.35074595
93	TRIM28	0.34061532
94	RPS6KA5	0.33028483
95	GSK3A	0.30788490
96	ROCK1	0.30372246
97	PRKACG	0.29599976
98	CAMK2B	0.29423798
99	TEC	0.28402507
100	EIF2AK1	0.27676896

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.88647552
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.78553026
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.42611326
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.41414577
5	Butanoate metabolism_Homo sapiens_hsa00650	2.38356529
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.37652595
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.36342726
8	Parkinsons disease_Homo sapiens_hsa05012	2.19622072
9	Propanoate metabolism_Homo sapiens_hsa00640	2.14801557
10	Phototransduction_Homo sapiens_hsa04744	2.10352949
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.00255043
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.97816580
13	Protein export_Homo sapiens_hsa03060	1.84863545
14	Fatty acid elongation_Homo sapiens_hsa00062	1.72742123
15	Nicotine addiction_Homo sapiens_hsa05033	1.72435279
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67504144
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.64150738
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62726382
19	Alzheimers disease_Homo sapiens_hsa05010	1.57942214
20	Peroxisome_Homo sapiens_hsa04146	1.56158392
21	Insulin secretion_Homo sapiens_hsa04911	1.50800658
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.45794426
23	Sulfur metabolism_Homo sapiens_hsa00920	1.45635112
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42587260
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.41231059
26	RNA polymerase_Homo sapiens_hsa03020	1.40426737
27	Caffeine metabolism_Homo sapiens_hsa00232	1.39229334
28	Fatty acid degradation_Homo sapiens_hsa00071	1.38586122
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.36699390
30	Collecting duct acid secretion_Homo sapiens_hsa04966	1.33701143
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30911910
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.29458533
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27770119
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27747397
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.27402690
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27137061
37	Huntingtons disease_Homo sapiens_hsa05016	1.26636925
38	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.23167934
39	Proteasome_Homo sapiens_hsa03050	1.21900099
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.21353589
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16269775
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.15330523
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.12563758
44	Regulation of autophagy_Homo sapiens_hsa04140	1.12198507
45	Circadian rhythm_Homo sapiens_hsa04710	1.10032514
46	Ether lipid metabolism_Homo sapiens_hsa00565	1.06761337
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93291957
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93061065
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91380465
50	Circadian entrainment_Homo sapiens_hsa04713	0.91220153
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.89636309
52	Retinol metabolism_Homo sapiens_hsa00830	0.87256138
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.86880418
54	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.86359572
55	Morphine addiction_Homo sapiens_hsa05032	0.86155743
56	Basal transcription factors_Homo sapiens_hsa03022	0.84312857
57	GABAergic synapse_Homo sapiens_hsa04727	0.83497083
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.82613256
59	Olfactory transduction_Homo sapiens_hsa04740	0.82477339
60	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.80710303
61	Salivary secretion_Homo sapiens_hsa04970	0.79648425
62	Metabolic pathways_Homo sapiens_hsa01100	0.79428897
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.75900731
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75656774
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75222641
66	Taste transduction_Homo sapiens_hsa04742	0.74529302
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74224534
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.73659015
69	ABC transporters_Homo sapiens_hsa02010	0.73247467
70	RNA degradation_Homo sapiens_hsa03018	0.73171361
71	Selenocompound metabolism_Homo sapiens_hsa00450	0.71466925
72	Purine metabolism_Homo sapiens_hsa00230	0.71130690
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70852735
74	Homologous recombination_Homo sapiens_hsa03440	0.70529236
75	Folate biosynthesis_Homo sapiens_hsa00790	0.70053181
76	Serotonergic synapse_Homo sapiens_hsa04726	0.69357690
77	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.66990120
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66457297
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.65101641
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64492959
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63514767
82	Histidine metabolism_Homo sapiens_hsa00340	0.63244556
83	Fanconi anemia pathway_Homo sapiens_hsa03460	0.58660086
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56871916
85	Amphetamine addiction_Homo sapiens_hsa05031	0.56602379
86	Renin secretion_Homo sapiens_hsa04924	0.55337728
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.54644582
88	One carbon pool by folate_Homo sapiens_hsa00670	0.54605003
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54329044
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.53967160
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51938632
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.51847582
93	Glutathione metabolism_Homo sapiens_hsa00480	0.49129662
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.48594559
95	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.48512309
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46142079
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.45066473
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44085252
99	PPAR signaling pathway_Homo sapiens_hsa03320	0.42681787
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.42508771

UBE2D4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »