UBE2E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.04168441
2nuclear pore complex assembly (GO:0051292)5.33673446
3ribosomal small subunit assembly (GO:0000028)5.33565111
4viral transcription (GO:0019083)5.08492762
5translational termination (GO:0006415)5.05970557
6ribosomal small subunit biogenesis (GO:0042274)4.67725957
7maturation of SSU-rRNA (GO:0030490)4.63059752
8translational elongation (GO:0006414)4.53025491
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45202834
10nuclear pore organization (GO:0006999)4.43838603
11cotranslational protein targeting to membrane (GO:0006613)4.38530576
12protein targeting to ER (GO:0045047)4.34992408
13protein localization to endosome (GO:0036010)4.34766130
14translational initiation (GO:0006413)4.32810431
15pore complex assembly (GO:0046931)4.23322526
16protein localization to endoplasmic reticulum (GO:0070972)4.19919736
17mitotic chromosome condensation (GO:0007076)4.18824814
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.16765029
19proteasome assembly (GO:0043248)4.12986633
20ribosomal large subunit biogenesis (GO:0042273)4.12046451
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.09468592
22regulation of early endosome to late endosome transport (GO:2000641)4.00276767
23viral life cycle (GO:0019058)3.97970209
24cellular protein complex disassembly (GO:0043624)3.96156826
25* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90658741
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.90169249
27termination of RNA polymerase III transcription (GO:0006386)3.83343939
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.83343939
29regulation of RNA export from nucleus (GO:0046831)3.69068324
30ribosome assembly (GO:0042255)3.67685029
31ribonucleoprotein complex biogenesis (GO:0022613)3.65057393
32* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64752322
33* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60997453
34chaperone-mediated protein transport (GO:0072321)3.57708458
35formation of translation preinitiation complex (GO:0001731)3.56827442
36regulation of nucleobase-containing compound transport (GO:0032239)3.53380824
37* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53317212
38regulation of cellular amino acid metabolic process (GO:0006521)3.50387732
39protein complex disassembly (GO:0043241)3.50185259
40RNA stabilization (GO:0043489)3.49510380
41mRNA stabilization (GO:0048255)3.49510380
42heterochromatin organization (GO:0070828)3.47741203
43regulation of NFAT protein import into nucleus (GO:0051532)3.46077311
44* negative regulation of ligase activity (GO:0051352)3.44672239
45* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.44672239
46rRNA processing (GO:0006364)3.42973700
47regulation of translational fidelity (GO:0006450)3.38726464
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38187521
49macromolecular complex disassembly (GO:0032984)3.35556005
50translation (GO:0006412)3.35265218
51pseudouridine synthesis (GO:0001522)3.35198641
52rRNA metabolic process (GO:0016072)3.34810800
53DNA replication initiation (GO:0006270)3.31498546
54negative regulation of erythrocyte differentiation (GO:0045647)3.31453284
55DNA strand elongation involved in DNA replication (GO:0006271)3.30800010
56planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30151258
57purine nucleobase biosynthetic process (GO:0009113)3.29724199
58DNA unwinding involved in DNA replication (GO:0006268)3.29724075
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25504855
60COPI coating of Golgi vesicle (GO:0048205)3.24237032
61Golgi transport vesicle coating (GO:0048200)3.24237032
62* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20480887
63nuclear-transcribed mRNA catabolic process (GO:0000956)3.20158077
64regulation of glucose import in response to insulin stimulus (GO:2001273)3.20041760
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18776749
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.17864940
67cellular protein complex localization (GO:0034629)3.17527495
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13735351
69ribosome biogenesis (GO:0042254)3.13176097
70mitotic metaphase plate congression (GO:0007080)3.12331166
71nucleobase biosynthetic process (GO:0046112)3.12113440
72* positive regulation of ligase activity (GO:0051351)3.11166723
73DNA strand elongation (GO:0022616)3.10099127
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10081416
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10081416
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08937418
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08937418
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08937418
793-UTR-mediated mRNA stabilization (GO:0070935)3.08517215
80positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.08455889
81telomere maintenance via semi-conservative replication (GO:0032201)3.07741483
827-methylguanosine mRNA capping (GO:0006370)3.06838396
83cellular component biogenesis (GO:0044085)3.06255016
84DNA replication checkpoint (GO:0000076)3.05913334
85mRNA catabolic process (GO:0006402)3.03942084
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02026486
87regulation of mammary gland epithelial cell proliferation (GO:0033599)3.01395357
88RNA capping (GO:0036260)3.01185257
897-methylguanosine RNA capping (GO:0009452)3.01185257
90cell cycle G1/S phase transition (GO:0044843)3.00083590
91G1/S transition of mitotic cell cycle (GO:0000082)3.00083590
92signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00039915
93signal transduction involved in DNA damage checkpoint (GO:0072422)3.00039915
94mitotic sister chromatid cohesion (GO:0007064)2.96461355
95termination of RNA polymerase I transcription (GO:0006363)2.96093637
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.94387767
97DNA topological change (GO:0006265)2.92740836
98protein targeting to membrane (GO:0006612)2.92504643
99protein retention in ER lumen (GO:0006621)2.92451191
100spliceosomal snRNP assembly (GO:0000387)2.92446583
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92266880
102GMP metabolic process (GO:0046037)2.92212652
103guanosine-containing compound biosynthetic process (GO:1901070)2.91306080
104protein localization to chromosome, centromeric region (GO:0071459)2.91016794
105rRNA modification (GO:0000154)2.90856051
106RNA catabolic process (GO:0006401)2.90027592
107establishment of integrated proviral latency (GO:0075713)2.89593010
108protein complex localization (GO:0031503)2.89531847
109regulation of helicase activity (GO:0051095)2.83990991
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82428334
111negative regulation of RNA splicing (GO:0033119)2.82063050
112transcription elongation from RNA polymerase I promoter (GO:0006362)2.81614768
113telomere maintenance via recombination (GO:0000722)2.81157713
114* regulation of ubiquitin-protein transferase activity (GO:0051438)2.77072432
115epithelial cell differentiation involved in prostate gland development (GO:0060742)2.76623701
116stress fiber assembly (GO:0043149)2.76391396
117positive regulation of protein export from nucleus (GO:0046827)2.75656087
118regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.74501399
119positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.74501399
120negative regulation of transcription by competitive promoter binding (GO:0010944)2.74494471
121activation of MAPKKK activity (GO:0000185)2.73464398
122pentose-phosphate shunt (GO:0006098)2.73123141
123* regulation of ligase activity (GO:0051340)2.71244638
124deoxyribose phosphate biosynthetic process (GO:0046385)2.69677955
1252-deoxyribonucleotide biosynthetic process (GO:0009265)2.69677955
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69374209
127maturation of 5.8S rRNA (GO:0000460)2.69139791
128paraxial mesoderm development (GO:0048339)2.68862240
129negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.68758080
130L-fucose catabolic process (GO:0042355)2.68646729
131fucose catabolic process (GO:0019317)2.68646729
132L-fucose metabolic process (GO:0042354)2.68646729
133adherens junction assembly (GO:0034333)2.68202302
134kinetochore assembly (GO:0051382)2.67959997
135regulation of vitamin D biosynthetic process (GO:0060556)2.67160243
136pinocytosis (GO:0006907)2.65560769
137modulation by symbiont of host cellular process (GO:0044068)2.64483668
138lymphoid progenitor cell differentiation (GO:0002320)2.64279184
139nucleobase-containing small molecule interconversion (GO:0015949)2.62510662
140regulation of cellular amine metabolic process (GO:0033238)2.61784339
141mitotic recombination (GO:0006312)2.61076335
142DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.60000235
143cell-substrate adherens junction assembly (GO:0007045)2.57054441
144focal adhesion assembly (GO:0048041)2.57054441
145spliceosomal tri-snRNP complex assembly (GO:0000244)2.57006712
146protein export from nucleus (GO:0006611)2.56582376
147pre-miRNA processing (GO:0031054)2.55662023
148cortical actin cytoskeleton organization (GO:0030866)2.55562689
149regulation of chromatin binding (GO:0035561)2.52877844
150myeloid cell homeostasis (GO:0002262)2.51140203
151embryonic process involved in female pregnancy (GO:0060136)2.50823135
152protein-DNA complex disassembly (GO:0032986)2.50749679
153nucleosome disassembly (GO:0006337)2.50749679
154response to peptidoglycan (GO:0032494)2.48713157
155cellular hyperosmotic response (GO:0071474)2.46188782
156activation of Rac GTPase activity (GO:0032863)2.43956408
157positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43822973
158NADPH regeneration (GO:0006740)2.41125010
159cellular response to virus (GO:0098586)2.38227680
160negative regulation of DNA repair (GO:0045738)2.36732597
161negative regulation of histone methylation (GO:0031061)2.36355034
162response to muramyl dipeptide (GO:0032495)2.35592648
163trophoblast giant cell differentiation (GO:0060707)2.34558078
164sister chromatid segregation (GO:0000819)2.33586143
165dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.33581044
166protein localization to microtubule (GO:0035372)2.32468466
167regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.32212438
168DNA duplex unwinding (GO:0032508)2.32205837
169protein localization to kinetochore (GO:0034501)2.31128174
170lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30425285
171epithelial cell-cell adhesion (GO:0090136)2.30303968
172negative regulation of striated muscle cell differentiation (GO:0051154)2.30254591
173folic acid-containing compound biosynthetic process (GO:0009396)2.29735064
174regulation of mRNA stability (GO:0043488)2.29165596
175glycosphingolipid catabolic process (GO:0046479)2.27831829
176establishment of viral latency (GO:0019043)2.25883219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.83527744
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38973369
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.17088975
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.15116228
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.77624542
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.55711768
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.53163822
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41354862
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36900407
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28336987
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22481389
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.21071066
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09682748
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05500065
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00572496
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.93841168
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82785824
18VDR_23849224_ChIP-Seq_CD4+_Human2.81479518
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73784436
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73228691
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58411963
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57211704
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52353084
24XRN2_22483619_ChIP-Seq_HELA_Human2.51066648
25CLOCK_20551151_ChIP-Seq_293T_Human2.48414931
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.44062112
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.33046834
28TTF2_22483619_ChIP-Seq_HELA_Human2.32234103
29GABP_19822575_ChIP-Seq_HepG2_Human2.23818451
30FOXP3_21729870_ChIP-Seq_TREG_Human2.20009119
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19041397
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18359955
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17783297
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.14705028
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10370536
36DCP1A_22483619_ChIP-Seq_HELA_Human2.09067851
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04643837
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03101396
39ZFX_18555785_ChIP-Seq_MESCs_Mouse2.01582319
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99788134
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95884193
42ELK1_19687146_ChIP-ChIP_HELA_Human1.92098410
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.91301674
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.87702370
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84961067
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84949439
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84225120
48MYC_22102868_ChIP-Seq_BL_Human1.81508947
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79239453
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78410704
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77302731
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74093237
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72601779
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.71297957
55TCF7_22412390_ChIP-Seq_EML_Mouse1.71204899
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71002309
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68472242
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67156938
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.65987955
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63506403
61* SPI1_23547873_ChIP-Seq_NB4_Human1.59933300
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59676817
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.58333421
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56734037
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55684058
66AR_21909140_ChIP-Seq_LNCAP_Human1.53647508
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52829949
68MYC_18940864_ChIP-ChIP_HL60_Human1.52473972
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52049579
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.49802960
71KDM2B_26808549_Chip-Seq_K562_Human1.47026796
72KDM2B_26808549_Chip-Seq_DND41_Human1.45903178
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45206495
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43948506
75IGF1R_20145208_ChIP-Seq_DFB_Human1.42964429
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42829809
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42709116
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42190008
79RACK7_27058665_Chip-Seq_MCF-7_Human1.42171711
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40300571
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39180239
82LXR_22292898_ChIP-Seq_THP-1_Human1.38835415
83CIITA_25753668_ChIP-Seq_RAJI_Human1.38200014
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36772448
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35774429
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35763139
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34530102
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34190585
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33907604
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33623164
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32035769
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.31386475
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30002811
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29596208
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29360595
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.27626449
97ZNF263_19887448_ChIP-Seq_K562_Human1.27268292
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27071609
99* E2F1_21310950_ChIP-Seq_MCF-7_Human1.26640665
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26413446
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26345538
102SCL_19346495_ChIP-Seq_HPC-7_Human1.26269964
103ELK1_22589737_ChIP-Seq_MCF10A_Human1.24855853
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24344434
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.23953134
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23770588
107UBF1/2_26484160_Chip-Seq_HMECs_Human1.23344832
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22047856
109NCOR1_26117541_ChIP-Seq_K562_Human1.21821645
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21547104
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.21209486
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20721363
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20420061
114CHD1_26751641_Chip-Seq_LNCaP_Human1.19476784
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19307780
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19307780
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19307780
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19261415
119KDM5A_27292631_Chip-Seq_BREAST_Human1.17372398
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16409115
121BP1_19119308_ChIP-ChIP_Hs578T_Human1.15430928
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15287551
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15149294
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15062978
125ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15052540
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14525285
127VDR_24763502_ChIP-Seq_THP-1_Human1.14186502
128WT1_19549856_ChIP-ChIP_CCG9911_Human1.14040539
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13934511
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13476669
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12791738
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10874291
133TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10200269
134* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09195153
135* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08997539
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08856053
137* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08736294
138ATF3_27146783_Chip-Seq_COLON_Human1.08181840
139MAF_26560356_Chip-Seq_TH1_Human1.07184957
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06837481
141* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06429948
142TFEB_21752829_ChIP-Seq_HELA_Human1.05780668
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05520166
144SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05370617
145FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04483321
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04285701
147* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03532995
148PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03397285
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02956352
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00607397
151CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99913714
152MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98176913
153CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96781968
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94745632
155IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93013924
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89756360
157DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87273058
158TAF15_26573619_Chip-Seq_HEK293_Human0.83323478
159IRF8_21731497_ChIP-ChIP_J774_Mouse0.83102723
160MYB_26560356_Chip-Seq_TH2_Human0.81243768
161KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80857615
162STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78641738
163IRF8_22096565_ChIP-ChIP_GC-B_Human0.78151383
164CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76265953
165CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75932305
166VDR_21846776_ChIP-Seq_THP-1_Human0.74830750
167EWS_26573619_Chip-Seq_HEK293_Human0.74497628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.83567351
2MP0003705_abnormal_hypodermis_morpholog4.23142241
3MP0001984_abnormal_olfaction3.59058968
4MP0004957_abnormal_blastocyst_morpholog3.56523123
5MP0002877_abnormal_melanocyte_morpholog3.54599817
6MP0003303_peritoneal_inflammation3.07046115
7MP0010094_abnormal_chromosome_stability3.03243443
8MP0004185_abnormal_adipocyte_glucose2.92326002
9MP0010234_abnormal_vibrissa_follicle2.67887581
10MP0010352_gastrointestinal_tract_polyps2.65916648
11MP0003111_abnormal_nucleus_morphology2.58374085
12MP0002396_abnormal_hematopoietic_system2.34145352
13MP0008058_abnormal_DNA_repair2.29904005
14MP0002102_abnormal_ear_morphology2.29329272
15MP0005058_abnormal_lysosome_morphology2.24091235
16MP0005076_abnormal_cell_differentiation2.23374411
17MP0003453_abnormal_keratinocyte_physiol2.20632538
18MP0003123_paternal_imprinting2.16147852
19MP0003077_abnormal_cell_cycle2.14769423
20MP0003300_gastrointestinal_ulcer2.13666641
21MP0005174_abnormal_tail_pigmentation2.12273722
22MP0002009_preneoplasia2.01208251
23MP0000490_abnormal_crypts_of2.00594152
24MP0005671_abnormal_response_to1.98786854
25MP0003566_abnormal_cell_adhesion1.94469784
26MP0006292_abnormal_olfactory_placode1.91339463
27MP0003763_abnormal_thymus_physiology1.88463663
28MP0003941_abnormal_skin_development1.88458114
29MP0005666_abnormal_adipose_tissue1.87778789
30MP0009785_altered_susceptibility_to1.84637741
31MP0001849_ear_inflammation1.83936428
32MP0009333_abnormal_splenocyte_physiolog1.82058276
33MP0001529_abnormal_vocalization1.80687765
34MP0003786_premature_aging1.79573113
35MP0004510_myositis1.76069175
36MP0008932_abnormal_embryonic_tissue1.73639372
37MP0003091_abnormal_cell_migration1.73182149
38MP0005257_abnormal_intraocular_pressure1.71518810
39MP0003938_abnormal_ear_development1.66551730
40MP0008057_abnormal_DNA_replication1.64485631
41MP0005084_abnormal_gallbladder_morpholo1.64206805
42MP0008260_abnormal_autophagy1.61976864
43MP0000537_abnormal_urethra_morphology1.61070773
44MP0009379_abnormal_foot_pigmentation1.60000867
45MP0008877_abnormal_DNA_methylation1.58498199
46MP0009053_abnormal_anal_canal1.56443636
47MP0002398_abnormal_bone_marrow1.56358384
48MP0001905_abnormal_dopamine_level1.55891029
49MP0005623_abnormal_meninges_morphology1.55614759
50MP0001835_abnormal_antigen_presentation1.54682939
51MP0004808_abnormal_hematopoietic_stem1.53977145
52MP0008438_abnormal_cutaneous_collagen1.53976276
53MP0004233_abnormal_muscle_weight1.53936467
54MP0009278_abnormal_bone_marrow1.53620656
55MP0001188_hyperpigmentation1.53024333
56MP0000685_abnormal_immune_system1.53015141
57MP0010307_abnormal_tumor_latency1.52773213
58MP0000465_gastrointestinal_hemorrhage1.49407060
59MP0005075_abnormal_melanosome_morpholog1.47833952
60MP0005423_abnormal_somatic_nervous1.47087243
61MP0008007_abnormal_cellular_replicative1.46807677
62MP0002638_abnormal_pupillary_reflex1.42812679
63MP0003718_maternal_effect1.39728833
64MP0000733_abnormal_muscle_development1.39699599
65MP0002796_impaired_skin_barrier1.39064535
66MP0009672_abnormal_birth_weight1.39008831
67MP0003880_abnormal_central_pattern1.38263947
68MP0005409_darkened_coat_color1.34782790
69MP0001915_intracranial_hemorrhage1.32750677
70MP0003724_increased_susceptibility_to1.31121284
71MP0002095_abnormal_skin_pigmentation1.30516877
72MP0001545_abnormal_hematopoietic_system1.30349397
73MP0005397_hematopoietic_system_phenotyp1.30349397
74MP0000858_altered_metastatic_potential1.29623562
75MP0000428_abnormal_craniofacial_morphol1.29450916
76MP0005025_abnormal_response_to1.25872407
77MP0001672_abnormal_embryogenesis/_devel1.24823639
78MP0005380_embryogenesis_phenotype1.24823639
79MP0002163_abnormal_gland_morphology1.24164601
80MP0008995_early_reproductive_senescence1.23649008
81MP0002722_abnormal_immune_system1.21799243
82MP0003984_embryonic_growth_retardation1.21757423
83MP0002420_abnormal_adaptive_immunity1.21211224
84MP0002697_abnormal_eye_size1.20840747
85MP0001819_abnormal_immune_cell1.20710851
86MP0002723_abnormal_immune_serum1.19266475
87MP0000716_abnormal_immune_system1.18424181
88MP0003448_altered_tumor_morphology1.17896167
89MP0001986_abnormal_taste_sensitivity1.16838517
90MP0000689_abnormal_spleen_morphology1.15163947
91MP0002088_abnormal_embryonic_growth/wei1.15010383
92MP0004145_abnormal_muscle_electrophysio1.14374068
93MP0002092_abnormal_eye_morphology1.13909849
94MP0004947_skin_inflammation1.13893029
95MP0005375_adipose_tissue_phenotype1.12246982
96MP0001853_heart_inflammation1.10647366
97MP0002429_abnormal_blood_cell1.10622613
98MP0002086_abnormal_extraembryonic_tissu1.10425268
99MP0003879_abnormal_hair_cell1.09482641
100MP0006036_abnormal_mitochondrial_physio1.09407115
101MP0001800_abnormal_humoral_immune1.07876236
102MP0002085_abnormal_embryonic_tissue1.06920811
103MP0002019_abnormal_tumor_incidence1.06825474
104MP0003315_abnormal_perineum_morphology1.06559571
105MP0002452_abnormal_antigen_presenting1.05253616
106MP0000747_muscle_weakness1.05210778
107MP0003866_abnormal_defecation1.05019571
108MP0005000_abnormal_immune_tolerance1.04769743
109MP0001697_abnormal_embryo_size1.04052677
110MP0000703_abnormal_thymus_morphology1.03777349
111MP0005501_abnormal_skin_physiology1.03703930
112MP0004272_abnormal_basement_membrane1.02447165
113MP0002184_abnormal_innervation1.00190821
114MP0002084_abnormal_developmental_patter0.99346732
115MP0005621_abnormal_cell_physiology0.99134444
116MP0002938_white_spotting0.97224202
117MP0000313_abnormal_cell_death0.96701439
118MP0010030_abnormal_orbit_morphology0.95346025
119MP0006276_abnormal_autonomic_nervous0.94603196
120MP0000343_altered_response_to0.93864829
121MP0010630_abnormal_cardiac_muscle0.93551678
122MP0001348_abnormal_lacrimal_gland0.92859451
123MP0010386_abnormal_urinary_bladder0.92543739
124MP0000372_irregular_coat_pigmentation0.92403675
125MP0002148_abnormal_hypersensitivity_rea0.92092190
126MP0002751_abnormal_autonomic_nervous0.91045799
127MP0000350_abnormal_cell_proliferation0.90688950
128MP0003329_amyloid_beta_deposits0.90598687
129MP0003385_abnormal_body_wall0.90306106
130MP0006035_abnormal_mitochondrial_morpho0.90270919
131MP0005464_abnormal_platelet_physiology0.89889300
132MP0002132_abnormal_respiratory_system0.89525846
133MP0001730_embryonic_growth_arrest0.88941599
134MP0003634_abnormal_glial_cell0.88094078
135MP0003943_abnormal_hepatobiliary_system0.87168145
136MP0005451_abnormal_body_composition0.86420094
137MP0003635_abnormal_synaptic_transmissio0.85371436
138MP0002998_abnormal_bone_remodeling0.85320994
139MP0002734_abnormal_mechanical_nocicepti0.84902207
140MP0002060_abnormal_skin_morphology0.84864602
141MP0001727_abnormal_embryo_implantation0.84614902
142MP0006054_spinal_hemorrhage0.84430078
143MP0001216_abnormal_epidermal_layer0.84151589
144MP0003942_abnormal_urinary_system0.82615577
145MP0009840_abnormal_foam_cell0.82447371
146MP0003890_abnormal_embryonic-extraembry0.81463057
147MP0003221_abnormal_cardiomyocyte_apopto0.81164697
148MP0004859_abnormal_synaptic_plasticity0.81069588
149MP0004381_abnormal_hair_follicle0.80895906
150MP0000604_amyloidosis0.80594666
151MP0004087_abnormal_muscle_fiber0.79215343
152MP0002896_abnormal_bone_mineralization0.78511073
153MP0000681_abnormal_thyroid_gland0.77930356
154MP0008789_abnormal_olfactory_epithelium0.77709321
155MP0000631_abnormal_neuroendocrine_gland0.77157326
156MP0004858_abnormal_nervous_system0.76542928
157MP0005384_cellular_phenotype0.76457177
158MP0005197_abnormal_uvea_morphology0.76333437
159MP0005193_abnormal_anterior_eye0.76086711
160MP0000358_abnormal_cell_content/0.76063184
161MP0005023_abnormal_wound_healing0.75274105
162MP0004197_abnormal_fetal_growth/weight/0.75007294
163MP0002006_tumorigenesis0.74990591
164MP0003567_abnormal_fetal_cardiomyocyte0.74643881
165MP0001485_abnormal_pinna_reflex0.74439691
166MP0000678_abnormal_parathyroid_gland0.74137819
167MP0001970_abnormal_pain_threshold0.73617604
168MP0000759_abnormal_skeletal_muscle0.73433701
169MP0002080_prenatal_lethality0.73290598
170MP0003690_abnormal_glial_cell0.71826627
171MP0003191_abnormal_cellular_cholesterol0.71785144
172MP0002089_abnormal_postnatal_growth/wei0.71639144
173MP0002166_altered_tumor_susceptibility0.70775793
174MP0003436_decreased_susceptibility_to0.70402264
175MP0010155_abnormal_intestine_physiology0.69267756
176MP0003075_altered_response_to0.69124535
177MP0001845_abnormal_inflammatory_respons0.67526429
178MP0002210_abnormal_sex_determination0.67380816

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.09551884
2Abnormal number of erythroid precursors (HP:0012131)4.62664926
3Aplastic anemia (HP:0001915)4.62494714
4Birth length less than 3rd percentile (HP:0003561)4.33668203
5Reticulocytopenia (HP:0001896)3.90214599
6Pallor (HP:0000980)3.52968570
7Abnormality of alanine metabolism (HP:0010916)3.51317166
8Hyperalaninemia (HP:0003348)3.51317166
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.51317166
10Chronic otitis media (HP:0000389)3.39447911
11Hyperacusis (HP:0010780)3.35923360
12Macrocytic anemia (HP:0001972)3.33364441
13Colon cancer (HP:0003003)3.27202676
14Oral leukoplakia (HP:0002745)3.11385017
15Elevated erythrocyte sedimentation rate (HP:0003565)3.09911242
16Cerebral hypomyelination (HP:0006808)3.08822610
17IgM deficiency (HP:0002850)3.02955840
18Rough bone trabeculation (HP:0100670)2.97815485
19Ankyloglossia (HP:0010296)2.97758892
20Postnatal microcephaly (HP:0005484)2.97139909
21Insomnia (HP:0100785)2.86791911
22Cortical dysplasia (HP:0002539)2.82387398
23Muscle fiber atrophy (HP:0100295)2.82051825
24Petechiae (HP:0000967)2.79364569
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76984686
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76984686
27Missing ribs (HP:0000921)2.70632410
28Poor head control (HP:0002421)2.60255074
29Hypothermia (HP:0002045)2.56341737
30Myositis (HP:0100614)2.54639149
31Pancytopenia (HP:0001876)2.54348106
32Achilles tendon contracture (HP:0001771)2.53426232
33Microretrognathia (HP:0000308)2.50913728
34CNS hypomyelination (HP:0003429)2.50743870
35Type 2 muscle fiber atrophy (HP:0003554)2.47032964
36Protrusio acetabuli (HP:0003179)2.46294296
37Premature rupture of membranes (HP:0001788)2.45633824
38Neurofibrillary tangles (HP:0002185)2.43112022
39Thrombocytosis (HP:0001894)2.42238501
40Cerebral inclusion bodies (HP:0100314)2.36866426
41Hepatocellular necrosis (HP:0001404)2.36570094
42Deep palmar crease (HP:0006191)2.35940648
43Syringomyelia (HP:0003396)2.35572018
44Spinal cord lesions (HP:0100561)2.35572018
45Overriding aorta (HP:0002623)2.35251323
46Asymmetry of the thorax (HP:0001555)2.34470891
47Abnormal trabecular bone morphology (HP:0100671)2.32588531
48Multiple enchondromatosis (HP:0005701)2.30847805
49Insidious onset (HP:0003587)2.30036221
50Termporal pattern (HP:0011008)2.30036221
51Progressive external ophthalmoplegia (HP:0000590)2.29923533
52Vertebral compression fractures (HP:0002953)2.29403479
53Pelvic girdle muscle weakness (HP:0003749)2.28382987
54Limb dystonia (HP:0002451)2.25375611
55Cleft eyelid (HP:0000625)2.24998060
56Shoulder girdle muscle weakness (HP:0003547)2.24357194
57Flat acetabular roof (HP:0003180)2.22497286
58Calcaneovalgus deformity (HP:0001848)2.20858712
59Spastic diplegia (HP:0001264)2.20218484
60Abnormality of the hip-girdle musculature (HP:0001445)2.19927851
61Abnormality of the musculature of the pelvis (HP:0001469)2.19927851
62Long palpebral fissure (HP:0000637)2.18557749
63Papilledema (HP:0001085)2.18004196
64Renal duplication (HP:0000075)2.17612008
65IgG deficiency (HP:0004315)2.16270678
66Abnormality of oral frenula (HP:0000190)2.16248505
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15917436
68Visual hallucinations (HP:0002367)2.15554676
69Premature graying of hair (HP:0002216)2.13202579
70Abnormality of the Achilles tendon (HP:0005109)2.12620579
71Upper motor neuron abnormality (HP:0002127)2.11558147
72Abnormality of the calcaneus (HP:0008364)2.10151040
73Breast hypoplasia (HP:0003187)2.08777860
74Delusions (HP:0000746)2.08381199
75Erythema (HP:0010783)2.08026563
76Focal motor seizures (HP:0011153)2.07011224
77Aplasia/Hypoplasia of the patella (HP:0006498)2.06940339
78Mitochondrial inheritance (HP:0001427)2.06466550
79Increased nuchal translucency (HP:0010880)2.06226543
80Myopathic facies (HP:0002058)2.04907998
81Deep philtrum (HP:0002002)2.04904270
82Abnormality of the thoracic spine (HP:0100711)2.04307904
83Respiratory difficulties (HP:0002880)2.04210924
84Deformed tarsal bones (HP:0008119)2.03552667
85Abnormality of the distal phalanx of the thumb (HP:0009617)2.03493121
86Pseudobulbar signs (HP:0002200)2.03120687
87Patellar aplasia (HP:0006443)2.02905755
88Type I transferrin isoform profile (HP:0003642)2.02895557
89Arnold-Chiari malformation (HP:0002308)2.02023241
90Entropion (HP:0000621)2.01947287
91Disproportionate tall stature (HP:0001519)2.01665654
92Elfin facies (HP:0004428)2.01581664
93Mitral regurgitation (HP:0001653)2.01458051
94Thoracic kyphosis (HP:0002942)2.01425836
95Centrally nucleated skeletal muscle fibers (HP:0003687)2.00482665
96Dysmetric saccades (HP:0000641)2.00038299
97Carpal bone hypoplasia (HP:0001498)1.98889615
98Progressive neurologic deterioration (HP:0002344)1.97855466
99Asplenia (HP:0001746)1.97675023
100Pancreatic fibrosis (HP:0100732)1.97555485
101Sparse eyelashes (HP:0000653)1.95483673
102Cellular immunodeficiency (HP:0005374)1.94212558
103Death in infancy (HP:0001522)1.94173905
104Exertional dyspnea (HP:0002875)1.94066983
105Premature ovarian failure (HP:0008209)1.93771916
10611 pairs of ribs (HP:0000878)1.93364181
107Reduced antithrombin III activity (HP:0001976)1.92545236
108Increased hepatocellular lipid droplets (HP:0006565)1.92106561
109Uterine leiomyosarcoma (HP:0002891)1.91446264
110Leiomyosarcoma (HP:0100243)1.91446264
111Abnormal large intestine physiology (HP:0012700)1.90823876
112Segmental peripheral demyelination/remyelination (HP:0003481)1.89473004
113Increased CSF lactate (HP:0002490)1.88940826
114Bowel incontinence (HP:0002607)1.88628942
115Hyperparathyroidism (HP:0000843)1.87657275
116Abnormality of liposaccharide metabolism (HP:0010968)1.87601901
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.87601901
118Abnormality of glycolipid metabolism (HP:0010969)1.87601901
119Disinhibition (HP:0000734)1.86479954
120Patellar dislocation (HP:0002999)1.85769270
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85413743
122Neonatal hypoglycemia (HP:0001998)1.85269114
123Relative macrocephaly (HP:0004482)1.84829046
124Severe visual impairment (HP:0001141)1.83591880
125Hypercalcemia (HP:0003072)1.83390657
126Turricephaly (HP:0000262)1.83358201
127Hepatic necrosis (HP:0002605)1.82819222
128Overgrowth (HP:0001548)1.82405750
129Increased serum lactate (HP:0002151)1.81046729
130Atrophy/Degeneration involving motor neurons (HP:0007373)1.79087309
131Horseshoe kidney (HP:0000085)1.78872306
132Slender long bone (HP:0003100)1.77987094
133Abnormal spermatogenesis (HP:0008669)1.77115203
134Lymphoma (HP:0002665)1.76940962
135Abnormal mitochondria in muscle tissue (HP:0008316)1.76361542
136Pointed chin (HP:0000307)1.75638468
137Cupped ribs (HP:0000887)1.75170314
138Acute necrotizing encephalopathy (HP:0006965)1.75114504
139Apathy (HP:0000741)1.74992406
140Personality changes (HP:0000751)1.74733889
141Basal ganglia calcification (HP:0002135)1.73516346
1423-Methylglutaconic aciduria (HP:0003535)1.73195102
143Abnormality of T cell physiology (HP:0011840)1.73175076
144Mitral valve prolapse (HP:0001634)1.72879270
145Cubitus valgus (HP:0002967)1.72728403
146Supernumerary spleens (HP:0009799)1.72354545
147Bladder diverticulum (HP:0000015)1.72235844
148Myelodysplasia (HP:0002863)1.71541311
149Diminished motivation (HP:0000745)1.71181769
150Ridged nail (HP:0001807)1.70368893
151Abnormality of the lumbar spine (HP:0100712)1.70056020
152Progressive muscle weakness (HP:0003323)1.69819917
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.69815767
154Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68994923
155Pancreatic cysts (HP:0001737)1.68812605
156Back pain (HP:0003418)1.68691376
157Degeneration of anterior horn cells (HP:0002398)1.68194411
158Abnormality of the anterior horn cell (HP:0006802)1.68194411
159Aplasia/hypoplasia of the uterus (HP:0008684)1.68091283
160Osteolytic defects of the hand bones (HP:0009699)1.67840164
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.67840164
162Deviation of the thumb (HP:0009603)1.67789465
163Encephalitis (HP:0002383)1.67506670
164Poor suck (HP:0002033)1.66578494
165Gastrointestinal stroma tumor (HP:0100723)1.66563477
166Abnormal protein glycosylation (HP:0012346)1.65791872
167Abnormal glycosylation (HP:0012345)1.65791872
168Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65791872
169Abnormal protein N-linked glycosylation (HP:0012347)1.65791872
170Trismus (HP:0000211)1.65357816
171Methylmalonic aciduria (HP:0012120)1.64371355
172Capillary hemangiomas (HP:0005306)1.63758515
173Acute lymphatic leukemia (HP:0006721)1.63595626
174Arterial tortuosity (HP:0005116)1.63536060
175Thick lower lip vermilion (HP:0000179)1.63036157
176Progressive inability to walk (HP:0002505)1.62832896
177Metaphyseal cupping (HP:0003021)1.62594249
178Hammertoe (HP:0001765)1.62543896
179Thoracolumbar scoliosis (HP:0002944)1.61881922
180Cellulitis (HP:0100658)1.60793163
181Nuclear cataract (HP:0100018)1.59526093
182Renovascular hypertension (HP:0100817)1.58435186
183Thin bony cortex (HP:0002753)1.57234810
184Increased variability in muscle fiber diameter (HP:0003557)1.56074645
185Selective tooth agenesis (HP:0001592)1.55982347
186Transitional cell carcinoma of the bladder (HP:0006740)1.55212406
187Genu recurvatum (HP:0002816)1.54738851
188Overlapping toe (HP:0001845)1.54412235
189Abnormality of the gastric mucosa (HP:0004295)1.53977097
190Increased connective tissue (HP:0009025)1.53741344
191Vertebral arch anomaly (HP:0008438)1.53543479
192Partial duplication of thumb phalanx (HP:0009944)1.53206664
193Abnormality of skeletal muscle fiber size (HP:0012084)1.52208540
194Gastrointestinal carcinoma (HP:0002672)1.51991482
195Malignant gastrointestinal tract tumors (HP:0006749)1.51991482
196Abnormality of the tricuspid valve (HP:0001702)1.51245341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.98948664
2STK163.77766062
3IRAK33.63431135
4WEE13.54842632
5BUB13.52433766
6TRIB33.48249384
7PRPF4B3.14081849
8TNIK3.04022965
9CDK192.88106198
10SMG12.86679173
11LATS22.72646313
12ICK2.54324186
13ACVR1B2.52555131
14DYRK32.51557520
15MAP3K122.47860022
16CDC72.13172903
17MKNK12.12062111
18CDK122.11913030
19MAP3K102.09925648
20PDGFRA2.07690106
21NLK1.83640279
22PIM21.82487740
23ARAF1.80277700
24SRPK11.79492609
25MAP3K141.79424864
26RIPK11.74808003
27CCNB11.73044306
28EIF2AK31.69774618
29EEF2K1.56950612
30MAP2K71.52181151
31MKNK21.51546392
32CAMK1D1.51357603
33CDK81.45372175
34KIT1.36561907
35MARK11.36445571
36TSSK61.36227100
37MAPKAPK51.32917680
38RPS6KA41.32884983
39PLK41.31912600
40DDR21.31168456
41NEK21.29260627
42TYRO31.28367933
43CAMK1G1.27961981
44BRSK21.27926398
45MAPKAPK31.25994356
46NME11.24313929
47BLK1.23413525
48CDK61.22517534
49SIK11.22445191
50TAOK21.20351152
51PKN21.18857306
52MUSK1.16229618
53ERBB31.16066466
54RAF11.13294452
55ZAP701.13112363
56DYRK21.12807626
57STK241.12152533
58TGFBR11.09219033
59NTRK11.08269722
60PAK41.06687429
61DMPK1.06220718
62TAF11.05602354
63IRAK21.03965974
64TBK11.01158518
65EIF2AK11.00837645
66TEC1.00807434
67BTK1.00534830
68NEK91.00148958
69MAP3K80.98889015
70VRK10.97686916
71RIPK40.96227253
72FGFR40.94179309
73TTN0.94128377
74CAMKK20.93470290
75NEK10.93292092
76PBK0.93171259
77AURKA0.91745421
78RPS6KB20.90879124
79ALK0.89359358
80MAP2K60.89176989
81SYK0.88758963
82MTOR0.87802439
83MINK10.87253197
84SIK30.86995634
85DAPK10.82595693
86PLK10.81188117
87CSNK1G30.80745161
88CDK40.77827591
89BRD40.76266912
90MAP3K130.73293341
91SCYL20.71920799
92KDR0.71789474
93MAP3K110.70721879
94BRSK10.68812808
95KSR20.68789977
96ATR0.67704201
97MARK20.66202151
98PAK20.66104353
99IRAK40.65058456
100LRRK20.64229605
101MAPK130.63611721
102CDK150.61512977
103LATS10.61343501
104KSR10.61241756
105NTRK30.61201559
106CSNK2A10.60922229
107CDK11A0.60652922
108MAP4K10.60379952
109ERN10.60329963
110BMX0.59278100
111PLK30.59164950
112CSNK2A20.59077914
113PDGFRB0.58693314
114CLK10.57081214
115MATK0.55966714
116ERBB40.55533554
117MAP2K30.55119440
118CDK180.54818877
119CDC42BPA0.53939223
120EIF2AK20.53449287
121AURKB0.52327277
122CHEK10.52009946
123FES0.51976185
124ABL20.51502633
125CDK140.51244584
126CSNK1G20.51021233
127PTK60.50786255
128STK30.50762351
129CDK70.49594009
130RPS6KL10.49300405
131RPS6KC10.49300405
132DAPK30.48412594
133MST40.48223473
134YES10.48202717
135EPHB20.48056538
136MAPK40.46808198
137IKBKE0.46792729
138PTK20.45381893
139SGK30.45105893
140AKT20.44609778
141MAP3K10.43146607
142MOS0.42441861
143MAP3K60.41763139
144BMPR1B0.41680723
145PINK10.40755354
146IKBKB0.40705634
147CSNK1G10.40381457
148EPHA30.40377287
149RPS6KA20.39491837
150ADRBK20.38778178
151PNCK0.38356813
152MAP2K40.38262254
153PASK0.36584962
154STK40.36321640
155LYN0.35740361
156ILK0.35696508
157MAPK100.35622101
158FGR0.35435328
159CSK0.33770465
160BRAF0.33278373
161IRAK10.32972640
162CHEK20.32520661
163CDK20.32141378
164MAP3K90.32085037
165TNK20.31967266
166DYRK1A0.30151718
167TTK0.29132427

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.76536490
2Proteasome_Homo sapiens_hsa030504.46541086
3RNA polymerase_Homo sapiens_hsa030203.80633322
4DNA replication_Homo sapiens_hsa030303.69485792
5Spliceosome_Homo sapiens_hsa030402.85574772
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83411692
7Pyrimidine metabolism_Homo sapiens_hsa002402.61505579
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41669585
9Mismatch repair_Homo sapiens_hsa034302.38904275
10Chronic myeloid leukemia_Homo sapiens_hsa052202.30152762
11RNA transport_Homo sapiens_hsa030132.21820261
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15744567
13Bladder cancer_Homo sapiens_hsa052192.13857866
14Nucleotide excision repair_Homo sapiens_hsa034202.04096220
15Homologous recombination_Homo sapiens_hsa034402.03966897
16Base excision repair_Homo sapiens_hsa034101.99763454
17Pancreatic cancer_Homo sapiens_hsa052121.96207037
18Cell cycle_Homo sapiens_hsa041101.94657644
19Protein export_Homo sapiens_hsa030601.93916545
20Basal transcription factors_Homo sapiens_hsa030221.73538172
21RNA degradation_Homo sapiens_hsa030181.72768992
22Prion diseases_Homo sapiens_hsa050201.72115272
23Renal cell carcinoma_Homo sapiens_hsa052111.67451703
24Other glycan degradation_Homo sapiens_hsa005111.66707391
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62535122
26Purine metabolism_Homo sapiens_hsa002301.62265339
27VEGF signaling pathway_Homo sapiens_hsa043701.60539377
28Non-small cell lung cancer_Homo sapiens_hsa052231.59241082
29Folate biosynthesis_Homo sapiens_hsa007901.53225700
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.51400898
31Olfactory transduction_Homo sapiens_hsa047401.50413784
32Endometrial cancer_Homo sapiens_hsa052131.46794449
33MicroRNAs in cancer_Homo sapiens_hsa052061.46542636
34Notch signaling pathway_Homo sapiens_hsa043301.38429474
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32996725
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27785851
37Adherens junction_Homo sapiens_hsa045201.26078345
38Small cell lung cancer_Homo sapiens_hsa052221.24469720
39Glioma_Homo sapiens_hsa052141.23643115
40Proteoglycans in cancer_Homo sapiens_hsa052051.22767091
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22513025
42Parkinsons disease_Homo sapiens_hsa050121.22489467
43Epstein-Barr virus infection_Homo sapiens_hsa051691.22449555
44ErbB signaling pathway_Homo sapiens_hsa040121.20161119
45p53 signaling pathway_Homo sapiens_hsa041151.18985542
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18721148
47Prostate cancer_Homo sapiens_hsa052151.18492555
48Systemic lupus erythematosus_Homo sapiens_hsa053221.12829379
49Regulation of autophagy_Homo sapiens_hsa041401.12082071
50N-Glycan biosynthesis_Homo sapiens_hsa005101.10364908
51Osteoclast differentiation_Homo sapiens_hsa043801.08253416
52Oocyte meiosis_Homo sapiens_hsa041141.07534830
53Amoebiasis_Homo sapiens_hsa051461.07196757
54Shigellosis_Homo sapiens_hsa051311.05658450
55* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05201445
56Prolactin signaling pathway_Homo sapiens_hsa049171.04821699
57Herpes simplex infection_Homo sapiens_hsa051681.03262425
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02169199
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01113924
60Hepatitis C_Homo sapiens_hsa051601.00202812
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99117607
62Oxidative phosphorylation_Homo sapiens_hsa001900.97736635
63Insulin signaling pathway_Homo sapiens_hsa049100.97407210
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96928046
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95815546
66Biosynthesis of amino acids_Homo sapiens_hsa012300.92606005
67HIF-1 signaling pathway_Homo sapiens_hsa040660.92143896
68mTOR signaling pathway_Homo sapiens_hsa041500.90980402
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89387140
70Antigen processing and presentation_Homo sapiens_hsa046120.88840156
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88104055
72Focal adhesion_Homo sapiens_hsa045100.87238034
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86992133
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86808713
75Alcoholism_Homo sapiens_hsa050340.85415880
76Malaria_Homo sapiens_hsa051440.85035804
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84990463
78Huntingtons disease_Homo sapiens_hsa050160.84931693
79Sulfur relay system_Homo sapiens_hsa041220.84578100
80mRNA surveillance pathway_Homo sapiens_hsa030150.82197774
81Toxoplasmosis_Homo sapiens_hsa051450.81773227
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79018689
83Type I diabetes mellitus_Homo sapiens_hsa049400.78286813
84Lysosome_Homo sapiens_hsa041420.77429527
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74405250
86Vitamin B6 metabolism_Homo sapiens_hsa007500.72923321
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.72907356
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.72629661
89Allograft rejection_Homo sapiens_hsa053300.72612388
90Pathways in cancer_Homo sapiens_hsa052000.72610262
91Melanoma_Homo sapiens_hsa052180.71407101
92Legionellosis_Homo sapiens_hsa051340.69238322
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68831386
94GnRH signaling pathway_Homo sapiens_hsa049120.68198047
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66938302
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66861562
97Carbon metabolism_Homo sapiens_hsa012000.66500538
98Asthma_Homo sapiens_hsa053100.66438963
99Leishmaniasis_Homo sapiens_hsa051400.66331703
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.65780452
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.65142648
102Estrogen signaling pathway_Homo sapiens_hsa049150.65039035
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.63784496
104Pentose phosphate pathway_Homo sapiens_hsa000300.63652177
105Thyroid cancer_Homo sapiens_hsa052160.63517067
106* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62882413
107Colorectal cancer_Homo sapiens_hsa052100.62509010
108Hepatitis B_Homo sapiens_hsa051610.61032798
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60893292
110Alzheimers disease_Homo sapiens_hsa050100.59376758
111Primary immunodeficiency_Homo sapiens_hsa053400.58871102
112Fanconi anemia pathway_Homo sapiens_hsa034600.58580107
113Choline metabolism in cancer_Homo sapiens_hsa052310.57587067
114Circadian rhythm_Homo sapiens_hsa047100.57304054
115Hippo signaling pathway_Homo sapiens_hsa043900.57239446
116Measles_Homo sapiens_hsa051620.56290920
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.54817790
118FoxO signaling pathway_Homo sapiens_hsa040680.54440091
119Basal cell carcinoma_Homo sapiens_hsa052170.53171446
120Long-term potentiation_Homo sapiens_hsa047200.51996689
121Nicotine addiction_Homo sapiens_hsa050330.51907456
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50871898
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49279056
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48666853
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47447245
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.46145594
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45959497
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45793643
129Non-homologous end-joining_Homo sapiens_hsa034500.45733585
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.44388972
131Vibrio cholerae infection_Homo sapiens_hsa051100.42947811
132Pertussis_Homo sapiens_hsa051330.41988200
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41686129
134Influenza A_Homo sapiens_hsa051640.39506711
135Rheumatoid arthritis_Homo sapiens_hsa053230.39493887
136Acute myeloid leukemia_Homo sapiens_hsa052210.38812191
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38753618
138B cell receptor signaling pathway_Homo sapiens_hsa046620.38429837
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36520213
140Hematopoietic cell lineage_Homo sapiens_hsa046400.35979635
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.35922222
142Salmonella infection_Homo sapiens_hsa051320.34621121
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.32540911
144T cell receptor signaling pathway_Homo sapiens_hsa046600.31723182
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30636493
146Caffeine metabolism_Homo sapiens_hsa002320.30458320
147Graft-versus-host disease_Homo sapiens_hsa053320.29560105
148Collecting duct acid secretion_Homo sapiens_hsa049660.29428136
149Apoptosis_Homo sapiens_hsa042100.29335069
150Viral carcinogenesis_Homo sapiens_hsa052030.29064884
151HTLV-I infection_Homo sapiens_hsa051660.28994643
152Synaptic vesicle cycle_Homo sapiens_hsa047210.26469841
153Sphingolipid metabolism_Homo sapiens_hsa006000.25694161
154TNF signaling pathway_Homo sapiens_hsa046680.25118638
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24639827
156Serotonergic synapse_Homo sapiens_hsa047260.24057907
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22458999
158Tuberculosis_Homo sapiens_hsa051520.21919025

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