UBE2E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.84026276
2positive regulation of mitochondrial fission (GO:0090141)4.83234192
3synaptic vesicle exocytosis (GO:0016079)4.75179390
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66079201
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.64369787
6chaperone-mediated protein transport (GO:0072321)4.61666561
7vocalization behavior (GO:0071625)4.60506810
8protein localization to synapse (GO:0035418)4.50863613
9glutamate secretion (GO:0014047)4.44881920
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41457029
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.37256743
12presynaptic membrane assembly (GO:0097105)4.36051704
13glutamate receptor signaling pathway (GO:0007215)4.19745930
14regulation of synaptic vesicle exocytosis (GO:2000300)4.16346171
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.12740404
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.12470286
17regulation of glutamate receptor signaling pathway (GO:1900449)4.12162108
18presynaptic membrane organization (GO:0097090)4.08015658
19synaptic transmission, glutamatergic (GO:0035249)4.01767924
20pyrimidine nucleobase catabolic process (GO:0006208)4.01473274
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94731930
22neuron-neuron synaptic transmission (GO:0007270)3.92616904
23gamma-aminobutyric acid signaling pathway (GO:0007214)3.91363618
24proteasome assembly (GO:0043248)3.90101615
25neurotransmitter-gated ion channel clustering (GO:0072578)3.86048784
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.84927699
27synaptic vesicle maturation (GO:0016188)3.83007361
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82899483
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77651715
30neuron recognition (GO:0008038)3.77576661
31cullin deneddylation (GO:0010388)3.73220684
32establishment of integrated proviral latency (GO:0075713)3.71195500
33locomotory exploration behavior (GO:0035641)3.71054659
34regulation of synaptic vesicle transport (GO:1902803)3.69714223
35neuronal action potential propagation (GO:0019227)3.69312527
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.58497918
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.57545270
38exploration behavior (GO:0035640)3.55559831
39postsynaptic membrane organization (GO:0001941)3.54857448
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49509646
41ATP synthesis coupled proton transport (GO:0015986)3.49509646
42protein deneddylation (GO:0000338)3.47858800
43regulation of neuronal synaptic plasticity (GO:0048168)3.47595411
44transmission of nerve impulse (GO:0019226)3.45847108
45synaptic vesicle endocytosis (GO:0048488)3.45551102
46establishment of viral latency (GO:0019043)3.44460527
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43935966
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42937995
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38488218
50establishment of mitochondrion localization (GO:0051654)3.35530430
51axonal fasciculation (GO:0007413)3.32965075
52regulation of postsynaptic membrane potential (GO:0060078)3.28991017
53neurotransmitter secretion (GO:0007269)3.28536967
54long-term synaptic potentiation (GO:0060291)3.26777693
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.24879682
56regulation of mitochondrial fission (GO:0090140)3.21300734
57positive regulation of synapse maturation (GO:0090129)3.21031596
58regulation of vesicle fusion (GO:0031338)3.20265919
59respiratory electron transport chain (GO:0022904)3.17934818
60gamma-aminobutyric acid transport (GO:0015812)3.17656247
61regulation of dendritic spine morphogenesis (GO:0061001)3.15440985
62protein targeting to mitochondrion (GO:0006626)3.14793423
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10471396
64regulation of glutamate secretion (GO:0014048)3.10243923
65regulation of synaptic plasticity (GO:0048167)3.08953619
66regulation of neurotransmitter secretion (GO:0046928)3.08947738
67startle response (GO:0001964)3.08761609
68protein localization to mitochondrion (GO:0070585)3.08340842
69positive regulation of membrane potential (GO:0045838)3.06934201
70electron transport chain (GO:0022900)3.06214379
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05557551
72negative regulation of membrane potential (GO:0045837)3.03654723
73de novo posttranslational protein folding (GO:0051084)3.02478461
74substrate-independent telencephalic tangential migration (GO:0021826)3.02191653
75substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.02191653
76protein neddylation (GO:0045116)3.00918790
77de novo protein folding (GO:0006458)2.99880773
78positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99240741
79long-term memory (GO:0007616)2.98983096
80positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.98858686
81mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.98858686
82behavioral response to cocaine (GO:0048148)2.98748693
83outer ear morphogenesis (GO:0042473)2.98226185
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96416335
85cerebellar granule cell differentiation (GO:0021707)2.96195933
86protein maturation by protein folding (GO:0022417)2.96115894
87innervation (GO:0060384)2.95605758
88positive regulation of synapse assembly (GO:0051965)2.95336246
89establishment of protein localization to mitochondrion (GO:0072655)2.92991596
90behavioral defense response (GO:0002209)2.92649222
91behavioral fear response (GO:0001662)2.92649222
92organelle disassembly (GO:1903008)2.92349789
93regulation of synapse structural plasticity (GO:0051823)2.91933131
94layer formation in cerebral cortex (GO:0021819)2.91899570
95neurotransmitter transport (GO:0006836)2.89713801
96negative regulation of amino acid transport (GO:0051956)2.89234284
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88854137
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88336436
99synapse assembly (GO:0007416)2.87538217
100dendritic spine morphogenesis (GO:0060997)2.85390416
101negative regulation of neurotransmitter transport (GO:0051589)2.84372998
102regulation of synapse maturation (GO:0090128)2.83998418
103learning (GO:0007612)2.83438994
104regulation of dendritic spine development (GO:0060998)2.82938283
105regulation of neurotransmitter transport (GO:0051588)2.82387662
106regulation of mitochondrial translation (GO:0070129)2.81948657
107ribonucleoprotein complex disassembly (GO:0032988)2.81020062
108cell migration in hindbrain (GO:0021535)2.80995429
109membrane depolarization (GO:0051899)2.80342823
110dendrite development (GO:0016358)2.79084233
111ATP hydrolysis coupled proton transport (GO:0015991)2.78934162
112energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.78934162
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78436905
114adult walking behavior (GO:0007628)2.78014398
115nucleobase catabolic process (GO:0046113)2.77799649
116ubiquinone metabolic process (GO:0006743)2.77572552
117membrane hyperpolarization (GO:0060081)2.77337702
118long-chain fatty acid biosynthetic process (GO:0042759)2.77214021
119serotonin receptor signaling pathway (GO:0007210)2.76945448
120synaptic transmission (GO:0007268)2.76573575
121response to histamine (GO:0034776)2.76437503
122dendrite morphogenesis (GO:0048813)2.76266304
123neurofilament cytoskeleton organization (GO:0060052)2.75366403
124protein complex biogenesis (GO:0070271)2.74230978
125polyamine metabolic process (GO:0006595)2.73926736
126fear response (GO:0042596)2.71838299
127regulation of synaptic transmission (GO:0050804)2.71600349
128righting reflex (GO:0060013)2.70985519
129regulation of respiratory system process (GO:0044065)2.70938374
130polyamine biosynthetic process (GO:0006596)2.70793926
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70131911
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.70131911
133NADH dehydrogenase complex assembly (GO:0010257)2.70131911
134regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.70072558
135regulation of female receptivity (GO:0045924)2.68788931
136positive regulation of neurotransmitter secretion (GO:0001956)2.68472506
137female mating behavior (GO:0060180)2.67425249
138DNA damage response, detection of DNA damage (GO:0042769)2.66864302
139negative regulation of dendrite development (GO:2000171)2.66463055
140negative regulation of dendrite morphogenesis (GO:0050774)2.66042636
141regulation of synaptic transmission, GABAergic (GO:0032228)2.65514124
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.64566812
143membrane depolarization during action potential (GO:0086010)2.64321717
144long term synaptic depression (GO:0060292)2.63005204
145regulation of synapse assembly (GO:0051963)2.62978601
146positive regulation of synaptic transmission (GO:0050806)2.62842481
147cellular potassium ion homeostasis (GO:0030007)2.61989422
148central nervous system projection neuron axonogenesis (GO:0021952)2.61941444
149positive regulation of dendritic spine development (GO:0060999)2.61847121
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58992835
151anterograde synaptic vesicle transport (GO:0048490)2.58087096
152ubiquinone biosynthetic process (GO:0006744)2.58020717
153short-term memory (GO:0007614)2.55036983
154axon extension involved in axon guidance (GO:0048846)2.53583720
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.53583720
156regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.51761544
157anterograde axon cargo transport (GO:0008089)2.51431696
158mitochondrion morphogenesis (GO:0070584)2.49031092
159mitochondrion transport along microtubule (GO:0047497)2.48869773
160establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48869773
161inner mitochondrial membrane organization (GO:0007007)2.47973775
162mitochondrial respiratory chain complex assembly (GO:0033108)2.47215934
163establishment of melanosome localization (GO:0032401)2.46712997
164negative regulation of ligase activity (GO:0051352)2.45569489
165negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.45569489
166nonmotile primary cilium assembly (GO:0035058)2.44823605
167regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.44011856
168L-serine metabolic process (GO:0006563)2.43211228
169axon extension (GO:0048675)2.42688582
170tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.41422587
171RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.41422587
172regulation of cellular amino acid metabolic process (GO:0006521)2.40678569
173striatum development (GO:0021756)2.39611918
174pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.39187398
175chromatin remodeling at centromere (GO:0031055)2.37757589
176negative regulation of microtubule polymerization (GO:0031115)2.37459524
177calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37257097
178positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.36964519
179heart process (GO:0003015)2.36204749
180heart contraction (GO:0060047)2.36204749
181adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.35880764
182CENP-A containing nucleosome assembly (GO:0034080)2.35768231
183transcription elongation from RNA polymerase III promoter (GO:0006385)2.35525098
184termination of RNA polymerase III transcription (GO:0006386)2.35525098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89727160
2GBX2_23144817_ChIP-Seq_PC3_Human4.19825986
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27172748
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02300766
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96316771
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92762695
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.90970251
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73773052
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64837555
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62240735
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59773103
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57899478
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56563565
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56563565
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.56248668
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55512460
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.52816564
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41778431
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38927576
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36574435
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35029923
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34361752
23* TAF15_26573619_Chip-Seq_HEK293_Human2.32460126
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30010518
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.29996362
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.24072995
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23564114
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.23059862
29REST_21632747_ChIP-Seq_MESCs_Mouse2.21176485
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10294969
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.09480244
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09351828
33* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09238779
34RNF2_27304074_Chip-Seq_ESCs_Mouse2.08945309
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98237224
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98232298
37AR_21572438_ChIP-Seq_LNCaP_Human1.93443206
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93024660
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91953166
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89752322
41DROSHA_22980978_ChIP-Seq_HELA_Human1.89582375
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87806449
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85398723
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83439024
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80796165
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80564003
47* P300_19829295_ChIP-Seq_ESCs_Human1.78216795
48* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76875251
49ELK1_19687146_ChIP-ChIP_HELA_Human1.76782612
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74389689
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.73761569
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.72115828
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71681121
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.71504908
55DCP1A_22483619_ChIP-Seq_HELA_Human1.69067731
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68862256
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67826816
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67614664
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66308374
60* CBX2_27304074_Chip-Seq_ESCs_Mouse1.66058428
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64935625
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62971266
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60386803
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59769103
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57471333
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.52251938
67* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51946417
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51489551
69GABP_19822575_ChIP-Seq_HepG2_Human1.50811049
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.50701582
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50425320
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.50309475
73FUS_26573619_Chip-Seq_HEK293_Human1.50066019
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47590142
75IGF1R_20145208_ChIP-Seq_DFB_Human1.47395311
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44496808
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43693473
78RNF2_27304074_Chip-Seq_NSC_Mouse1.43534429
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43312990
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43295908
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43117527
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42318937
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42284269
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41246607
85TTF2_22483619_ChIP-Seq_HELA_Human1.35724456
86* AR_25329375_ChIP-Seq_VCAP_Human1.35608139
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33620901
88VDR_23849224_ChIP-Seq_CD4+_Human1.32124052
89VDR_22108803_ChIP-Seq_LS180_Human1.31899194
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31210060
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30505590
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28434710
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28246467
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.27945871
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27721344
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27282314
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.26942553
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26398902
99MYC_18940864_ChIP-ChIP_HL60_Human1.25615349
100* STAT3_23295773_ChIP-Seq_U87_Human1.24796185
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24733230
102* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22504665
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22212872
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.21013431
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20739202
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20734421
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20414267
108* ER_23166858_ChIP-Seq_MCF-7_Human1.19098593
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18739666
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17716203
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.17553840
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.16504876
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15643037
114* EWS_26573619_Chip-Seq_HEK293_Human1.15067587
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15066610
116* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15018875
117REST_19997604_ChIP-ChIP_NEURONS_Mouse1.14983762
118TCF4_23295773_ChIP-Seq_U87_Human1.14331819
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14222398
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14117617
121ZNF274_21170338_ChIP-Seq_K562_Hela1.13759185
122YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13597064
123SRF_21415370_ChIP-Seq_HL-1_Mouse1.13033918
124SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12410007
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.12121380
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.12116414
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11745779
128TP53_18474530_ChIP-ChIP_U2OS_Human1.11181053
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09865932
130* RUNX2_22187159_ChIP-Seq_PCA_Human1.09652938
131HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08966859
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.08684238
133NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08513610
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08223960
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07903887
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07903887
137SMAD_19615063_ChIP-ChIP_OVARY_Human1.07874397
138YY1_21170310_ChIP-Seq_MESCs_Mouse1.07838561
139XRN2_22483619_ChIP-Seq_HELA_Human1.07316531
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06694621
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06479860
142* JUN_21703547_ChIP-Seq_K562_Human1.06363066
143RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05999286
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05817550
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03376395
146* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03095622
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03070230
148* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02584346
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02564772
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02083311
151RING1B_27294783_Chip-Seq_NPCs_Mouse1.01898888
152* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01663540
153AHR_22903824_ChIP-Seq_MCF-7_Human1.01270700
154E2F1_18555785_Chip-Seq_ESCs_Mouse1.00018287
155FOXP3_21729870_ChIP-Seq_TREG_Human1.00000703
156KDM2B_26808549_Chip-Seq_REH_Human0.99296069
157CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99222239
158* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98242042
159CMYC_18555785_Chip-Seq_ESCs_Mouse0.96501150
160* AR_19668381_ChIP-Seq_PC3_Human0.95817396
161* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95319359
162P53_22387025_ChIP-Seq_ESCs_Mouse0.93643842
163ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93521985
164MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92390576
165SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90151262
166SMAD4_21741376_ChIP-Seq_HESCs_Human0.89705049
167GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88744246
168YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88693755
169BCAT_22108803_ChIP-Seq_LS180_Human0.88344090
170RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88108460
171SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87816052
172PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87491759
173PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86294570
174LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85236664
175* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84832755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.57510209
2MP0004859_abnormal_synaptic_plasticity5.27872730
3MP0004270_analgesia3.57832283
4MP0003635_abnormal_synaptic_transmissio3.56476429
5MP0001968_abnormal_touch/_nociception3.31001259
6MP0009745_abnormal_behavioral_response3.11337236
7MP0002736_abnormal_nociception_after2.99515516
8MP0002064_seizures2.92234593
9MP0002063_abnormal_learning/memory/cond2.92050135
10MP0002735_abnormal_chemical_nociception2.80488420
11MP0009046_muscle_twitch2.66072256
12MP0002572_abnormal_emotion/affect_behav2.63255875
13MP0002272_abnormal_nervous_system2.61166714
14MP0001486_abnormal_startle_reflex2.60730257
15MP0002734_abnormal_mechanical_nocicepti2.59422635
16MP0006276_abnormal_autonomic_nervous2.29671540
17MP0003121_genomic_imprinting2.25482574
18MP0005423_abnormal_somatic_nervous2.22224966
19MP0002102_abnormal_ear_morphology2.20782307
20MP0001501_abnormal_sleep_pattern2.17181673
21MP0001440_abnormal_grooming_behavior2.16099110
22MP0002067_abnormal_sensory_capabilities2.06141974
23MP0000778_abnormal_nervous_system2.04147698
24MP0008877_abnormal_DNA_methylation2.03165370
25MP0002733_abnormal_thermal_nociception1.97884647
26MP0001970_abnormal_pain_threshold1.91488696
27MP0002184_abnormal_innervation1.87738059
28MP0001188_hyperpigmentation1.86743500
29MP0009379_abnormal_foot_pigmentation1.83873009
30MP0001529_abnormal_vocalization1.82680072
31MP0001984_abnormal_olfaction1.79288178
32MP0008789_abnormal_olfactory_epithelium1.77398368
33MP0005646_abnormal_pituitary_gland1.73725692
34MP0003123_paternal_imprinting1.62940605
35MP0001905_abnormal_dopamine_level1.60784688
36MP0002822_catalepsy1.59566369
37MP0004142_abnormal_muscle_tone1.58447817
38MP0004924_abnormal_behavior1.57284062
39MP0005386_behavior/neurological_phenoty1.57284062
40MP0003941_abnormal_skin_development1.56703107
41MP0002557_abnormal_social/conspecific_i1.56278536
42MP0000955_abnormal_spinal_cord1.53677482
43MP0005171_absent_coat_pigmentation1.51900983
44MP0003890_abnormal_embryonic-extraembry1.50052001
45MP0005645_abnormal_hypothalamus_physiol1.49540092
46MP0003122_maternal_imprinting1.49301203
47MP0003329_amyloid_beta_deposits1.46009137
48MP0001502_abnormal_circadian_rhythm1.44511294
49MP0008569_lethality_at_weaning1.44274634
50MP0000049_abnormal_middle_ear1.40673524
51MP0008058_abnormal_DNA_repair1.38831221
52MP0001542_abnormal_bone_strength1.38755350
53MP0002882_abnormal_neuron_morphology1.38214052
54MP0004742_abnormal_vestibular_system1.34883136
55MP0004811_abnormal_neuron_physiology1.34815668
56MP0003186_abnormal_redox_activity1.33913278
57MP0003879_abnormal_hair_cell1.33095175
58MP0004885_abnormal_endolymph1.32854624
59MP0002233_abnormal_nose_morphology1.32522425
60MP0002066_abnormal_motor_capabilities/c1.32047857
61MP0003221_abnormal_cardiomyocyte_apopto1.29646192
62MP0004858_abnormal_nervous_system1.29143030
63MP0000750_abnormal_muscle_regeneration1.28987190
64MP0010030_abnormal_orbit_morphology1.27964708
65MP0002876_abnormal_thyroid_physiology1.25976831
66MP0003787_abnormal_imprinting1.22006777
67MP0005551_abnormal_eye_electrophysiolog1.19317299
68MP0000920_abnormal_myelination1.15842710
69MP0006292_abnormal_olfactory_placode1.15413893
70MP0008932_abnormal_embryonic_tissue1.12916009
71MP0001963_abnormal_hearing_physiology1.10847812
72MP0002653_abnormal_ependyma_morphology1.09549317
73MP0006035_abnormal_mitochondrial_morpho1.09237235
74MP0010386_abnormal_urinary_bladder1.05643705
75MP0003633_abnormal_nervous_system1.02257182
76MP0009780_abnormal_chondrocyte_physiolo1.01896920
77MP0004215_abnormal_myocardial_fiber1.01845310
78MP0002752_abnormal_somatic_nervous1.00250784
79MP0004133_heterotaxia0.98144089
80MP0003631_nervous_system_phenotype0.96244161
81MP0002229_neurodegeneration0.96033921
82MP0002152_abnormal_brain_morphology0.95866616
83MP0002837_dystrophic_cardiac_calcinosis0.95750723
84MP0008007_abnormal_cellular_replicative0.91909977
85MP0001293_anophthalmia0.86889826
86MP0002069_abnormal_eating/drinking_beha0.86883336
87MP0003634_abnormal_glial_cell0.85684559
88MP0002295_abnormal_pulmonary_circulatio0.85313748
89MP0000026_abnormal_inner_ear0.84907716
90MP0001177_atelectasis0.84633719
91MP0003567_abnormal_fetal_cardiomyocyte0.84523333
92MP0003861_abnormal_nervous_system0.84492330
93MP0000631_abnormal_neuroendocrine_gland0.84479606
94MP0000358_abnormal_cell_content/0.84336444
95MP0004147_increased_porphyrin_level0.83883449
96MP0004085_abnormal_heartbeat0.83470449
97MP0003937_abnormal_limbs/digits/tail_de0.82531051
98MP0004145_abnormal_muscle_electrophysio0.82072101
99MP0005253_abnormal_eye_physiology0.81891203
100MP0001485_abnormal_pinna_reflex0.81796084
101MP0002909_abnormal_adrenal_gland0.81461967
102MP0000569_abnormal_digit_pigmentation0.81199434
103MP0001664_abnormal_digestion0.80612767
104MP0008874_decreased_physiological_sensi0.80598551
105MP0000343_altered_response_to0.77047670
106MP0000751_myopathy0.76414474
107MP0003755_abnormal_palate_morphology0.76394695
108MP0005248_abnormal_Harderian_gland0.75452819
109MP0003632_abnormal_nervous_system0.75054614
110MP0005409_darkened_coat_color0.73523675
111MP0005499_abnormal_olfactory_system0.73510639
112MP0005394_taste/olfaction_phenotype0.73510639
113MP0000647_abnormal_sebaceous_gland0.73157054
114MP0003690_abnormal_glial_cell0.73088865
115MP0003315_abnormal_perineum_morphology0.72765456
116MP0005451_abnormal_body_composition0.72300453
117MP0008872_abnormal_physiological_respon0.71791354
118MP0002210_abnormal_sex_determination0.70605578
119MP0002177_abnormal_outer_ear0.70049250
120MP0002751_abnormal_autonomic_nervous0.67279379
121MP0001727_abnormal_embryo_implantation0.67259528
122MP0002090_abnormal_vision0.66810759
123MP0005535_abnormal_body_temperature0.66794258
124MP0004510_myositis0.66062862
125MP0001986_abnormal_taste_sensitivity0.63853564
126MP0004484_altered_response_of0.63158339
127MP0003938_abnormal_ear_development0.58761299
128MP0000604_amyloidosis0.55813489
129MP0003137_abnormal_impulse_conducting0.55337729
130MP0001299_abnormal_eye_distance/0.54371530
131MP0001943_abnormal_respiration0.53572432
132MP0005623_abnormal_meninges_morphology0.53214450
133MP0002638_abnormal_pupillary_reflex0.51668538
134MP0003136_yellow_coat_color0.50934185
135MP0001346_abnormal_lacrimal_gland0.50802147
136MP0005595_abnormal_vascular_smooth0.50650963
137MP0002234_abnormal_pharynx_morphology0.49637697
138MP0006072_abnormal_retinal_apoptosis0.48542408
139MP0005195_abnormal_posterior_eye0.48065674
140MP0003868_abnormal_feces_composition0.46552961

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.59406062
2Myokymia (HP:0002411)6.19573043
3Epileptic encephalopathy (HP:0200134)5.16069515
4Febrile seizures (HP:0002373)5.09697173
5Focal seizures (HP:0007359)4.82532845
6Atonic seizures (HP:0010819)4.82155484
7Hyperventilation (HP:0002883)4.22828769
8Progressive cerebellar ataxia (HP:0002073)4.17332213
9Visual hallucinations (HP:0002367)3.89069302
10Absence seizures (HP:0002121)3.88990399
11Abnormal mitochondria in muscle tissue (HP:0008316)3.72016899
12Cortical dysplasia (HP:0002539)3.69726386
13Dialeptic seizures (HP:0011146)3.69160292
14Mitochondrial inheritance (HP:0001427)3.48187577
15Generalized tonic-clonic seizures (HP:0002069)3.33858975
16Progressive macrocephaly (HP:0004481)3.28619578
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23902045
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23902045
19Acute encephalopathy (HP:0006846)3.20432994
20Increased hepatocellular lipid droplets (HP:0006565)3.14210920
21Increased CSF lactate (HP:0002490)3.08100366
22Hepatocellular necrosis (HP:0001404)3.01394520
23Lipid accumulation in hepatocytes (HP:0006561)3.00982359
24Dysmetria (HP:0001310)3.00377775
25Supranuclear gaze palsy (HP:0000605)2.97057474
26Broad-based gait (HP:0002136)2.94865556
27Action tremor (HP:0002345)2.94529164
28Abnormality of the labia minora (HP:0012880)2.87379367
29Gaze-evoked nystagmus (HP:0000640)2.86258352
30Neurofibrillary tangles (HP:0002185)2.83643076
31Absent speech (HP:0001344)2.79367870
32Scanning speech (HP:0002168)2.75120826
33Amblyopia (HP:0000646)2.74893931
34Renal Fanconi syndrome (HP:0001994)2.74303511
35Abnormality of the corticospinal tract (HP:0002492)2.66914308
36Hepatic necrosis (HP:0002605)2.65056134
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.64907096
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64907096
39Pheochromocytoma (HP:0002666)2.62132170
40Increased serum pyruvate (HP:0003542)2.61905594
41Cerebral inclusion bodies (HP:0100314)2.60284378
42Epileptiform EEG discharges (HP:0011182)2.59020034
43Drooling (HP:0002307)2.58400802
44Excessive salivation (HP:0003781)2.58400802
45Atrophy/Degeneration involving motor neurons (HP:0007373)2.58374281
46Dysdiadochokinesis (HP:0002075)2.57837330
47Ankle clonus (HP:0011448)2.55314234
48Retinal dysplasia (HP:0007973)2.53940298
49Progressive inability to walk (HP:0002505)2.53126048
50Increased intramyocellular lipid droplets (HP:0012240)2.51825421
51Abnormality of glycolysis (HP:0004366)2.51094341
52Inability to walk (HP:0002540)2.49169141
53Anxiety (HP:0000739)2.48088726
54Blue irides (HP:0000635)2.46975726
55Cerebral edema (HP:0002181)2.43539182
56Abnormality of the lower motor neuron (HP:0002366)2.42484421
57Spastic gait (HP:0002064)2.41437394
58Fetal akinesia sequence (HP:0001989)2.41075663
59Gait imbalance (HP:0002141)2.39082982
60Colon cancer (HP:0003003)2.38753681
61EEG with generalized epileptiform discharges (HP:0011198)2.35488829
62Poor eye contact (HP:0000817)2.34861080
63Degeneration of anterior horn cells (HP:0002398)2.33320488
64Abnormality of the anterior horn cell (HP:0006802)2.33320488
65Abnormal eating behavior (HP:0100738)2.33174210
66Sensory axonal neuropathy (HP:0003390)2.31854388
67Neuroendocrine neoplasm (HP:0100634)2.31209606
68Urinary bladder sphincter dysfunction (HP:0002839)2.29944458
69Hyperglycinemia (HP:0002154)2.28605049
70Amyotrophic lateral sclerosis (HP:0007354)2.28341076
71Exercise-induced muscle cramps (HP:0003710)2.28316417
72Torticollis (HP:0000473)2.27565390
73Polyphagia (HP:0002591)2.26885442
74Upper limb muscle weakness (HP:0003484)2.24904849
75Truncal ataxia (HP:0002078)2.23031035
76Impaired vibration sensation in the lower limbs (HP:0002166)2.21217543
77Limb dystonia (HP:0002451)2.19998997
78Termporal pattern (HP:0011008)2.17920550
79Insidious onset (HP:0003587)2.17920550
80Increased muscle lipid content (HP:0009058)2.16947259
81Exercise intolerance (HP:0003546)2.16580073
82Dynein arm defect of respiratory motile cilia (HP:0012255)2.16431976
83Absent/shortened dynein arms (HP:0200106)2.16431976
84Medial flaring of the eyebrow (HP:0010747)2.16224058
85Respiratory failure (HP:0002878)2.15964173
86Delayed gross motor development (HP:0002194)2.14546227
87Thickened helices (HP:0000391)2.14011209
88Akinesia (HP:0002304)2.13234957
89Generalized myoclonic seizures (HP:0002123)2.13136983
90CNS hypomyelination (HP:0003429)2.11190618
91Shoulder girdle muscle weakness (HP:0003547)2.10716064
92Exertional dyspnea (HP:0002875)2.09477672
93Hypsarrhythmia (HP:0002521)2.09386740
94Failure to thrive in infancy (HP:0001531)2.08420243
95Depression (HP:0000716)2.07924844
96Lactic acidosis (HP:0003128)2.07789393
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07185369
98Abnormality of alanine metabolism (HP:0010916)2.07185369
99Hyperalaninemia (HP:0003348)2.07185369
100Genetic anticipation (HP:0003743)2.05957543
101Protruding tongue (HP:0010808)2.05428703
102Congenital primary aphakia (HP:0007707)2.04626750
103Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02725865
104Focal dystonia (HP:0004373)2.01887613
105Abnormal hair whorl (HP:0010721)2.01245285
106Postural instability (HP:0002172)1.97940004
107Lower limb muscle weakness (HP:0007340)1.96673448
108Poor suck (HP:0002033)1.96660444
109Genital tract atresia (HP:0001827)1.95622708
110Hypoplastic left heart (HP:0004383)1.95472145
111Methylmalonic acidemia (HP:0002912)1.95453316
112Urinary urgency (HP:0000012)1.95343614
113Specific learning disability (HP:0001328)1.95240533
114Impaired social interactions (HP:0000735)1.95161765
115Abnormal social behavior (HP:0012433)1.95161765
116Abnormality of the motor neurons (HP:0002450)1.94747026
117Abnormal neuron morphology (HP:0012757)1.94747026
118Hydroureter (HP:0000072)1.93963540
119Postnatal microcephaly (HP:0005484)1.92268791
120Diminished motivation (HP:0000745)1.92048671
121Nephrogenic diabetes insipidus (HP:0009806)1.91739705
122Vaginal atresia (HP:0000148)1.91668124
123Parakeratosis (HP:0001036)1.91296167
124Aplasia involving bones of the upper limbs (HP:0009823)1.90313467
125Aplasia of the phalanges of the hand (HP:0009802)1.90313467
126Aplasia involving bones of the extremities (HP:0009825)1.90313467
127Leukodystrophy (HP:0002415)1.90226161
128Sensorimotor neuropathy (HP:0007141)1.89541766
129Craniofacial dystonia (HP:0012179)1.89109413
130Broad foot (HP:0001769)1.88040921
131Narrow nasal bridge (HP:0000446)1.87946862
132Delusions (HP:0000746)1.87808547
133Increased serum lactate (HP:0002151)1.87359875
134Hemiparesis (HP:0001269)1.85436242
135Stenosis of the external auditory canal (HP:0000402)1.85252690
136Apathy (HP:0000741)1.85150817
137Mutism (HP:0002300)1.85131232
138Cerebral hypomyelination (HP:0006808)1.84660305
139Abnormality of salivation (HP:0100755)1.84377501
140Agnosia (HP:0010524)1.83010355
141Sclerocornea (HP:0000647)1.82753416
142Esotropia (HP:0000565)1.80238371
143Oligomenorrhea (HP:0000876)1.79962474
144Decreased muscle mass (HP:0003199)1.79445211
145Short tibia (HP:0005736)1.79238235
146Abnormality of the musculature of the pelvis (HP:0001469)1.78642152
147Abnormality of the hip-girdle musculature (HP:0001445)1.78642152
148Widely spaced teeth (HP:0000687)1.78193668
149Acute necrotizing encephalopathy (HP:0006965)1.78058425
150Incomplete penetrance (HP:0003829)1.78051088
151Intention tremor (HP:0002080)1.77838900
152Medulloblastoma (HP:0002885)1.75604954
153Abnormality of binocular vision (HP:0011514)1.74964804
154Diplopia (HP:0000651)1.74964804
155Type II lissencephaly (HP:0007260)1.74846550
156Dysphonia (HP:0001618)1.74807343
157Fair hair (HP:0002286)1.74531618
158Methylmalonic aciduria (HP:0012120)1.74354756
159Septo-optic dysplasia (HP:0100842)1.73952007
160Abnormality of renal resorption (HP:0011038)1.73756084
161Morphological abnormality of the pyramidal tract (HP:0002062)1.73538147
162Megalencephaly (HP:0001355)1.73333775
163Psychosis (HP:0000709)1.70702444
164Pancreatic fibrosis (HP:0100732)1.70397608
165Anosmia (HP:0000458)1.70132611
166Agitation (HP:0000713)1.69610695
167Sleep apnea (HP:0010535)1.68182156
168Spastic tetraplegia (HP:0002510)1.67423338
169Ulnar claw (HP:0001178)1.66757887
170Abnormality of midbrain morphology (HP:0002418)1.66130548
171Molar tooth sign on MRI (HP:0002419)1.66130548
172Emotional lability (HP:0000712)1.65588661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.43758502
2EPHA44.24591021
3CASK3.96722304
4MAP2K73.02479902
5TRIM282.89053130
6MAP3K42.77000104
7PRPF4B2.69251880
8LIMK12.55959286
9MAP3K92.51674228
10MARK12.37991139
11TESK12.30645061
12MAP3K122.30625722
13TNIK2.23858720
14MINK12.19310774
15NEK12.05016278
16VRK21.95881235
17MAP2K41.93243450
18PLK21.93098927
19DAPK21.91949780
20DYRK21.76263096
21BCKDK1.74286945
22GRK51.73225136
23MAP4K21.65967863
24RIPK41.64047754
25CDK191.61791638
26OXSR11.60162759
27ARAF1.57442399
28DYRK31.56790348
29PAK61.55263469
30ERBB31.55242184
31MAPK131.53622440
32FLT31.52722752
33BUB11.49221244
34CSNK1G11.49199230
35SIK31.46565958
36MAP3K131.45281732
37EPHB21.39967368
38SRPK11.37714829
39NTRK21.37602822
40WNK31.33018098
41BCR1.32926118
42CDK51.29908616
43NTRK11.24813758
44STK391.24766934
45PIM21.24739181
46RPS6KA41.23242111
47CAMK2A1.22466263
48KSR21.21422171
49PNCK1.20426948
50KSR11.18364498
51CAMK2B1.17907799
52PRKCG1.13508608
53SGK4941.11728112
54SGK2231.11728112
55FES1.08958205
56BMPR21.08543381
57DAPK11.03746098
58PTK2B1.01742223
59FGR0.98440035
60TESK20.97749611
61VRK10.97486026
62CCNB10.96603694
63MOS0.95663401
64NME20.95076024
65NME10.94505187
66MUSK0.93690555
67FER0.93593707
68MAP3K60.92590988
69UHMK10.91321029
70PLK30.89068532
71AKT30.88454389
72CAMK2D0.87764503
73PRKCE0.86521038
74CSNK1G20.84754366
75CDC70.83994372
76DAPK30.82887965
77ABL20.82405369
78PRKD30.82327097
79PINK10.81807613
80LATS20.81710542
81GRK10.80409701
82CAMK2G0.79865020
83SGK20.78940312
84SIK20.78698743
85PHKG10.76298507
86PHKG20.76298507
87PAK30.76257546
88PKN10.75939310
89GRK70.74904687
90PDK20.74314190
91ADRBK20.73841420
92CDK140.73475245
93DYRK1A0.73070268
94TAF10.72624797
95CDK180.72301132
96MAP3K110.71821879
97CAMK10.71644558
98PLK10.69251730
99MKNK10.66969317
100MAP3K50.66464115
101CDK150.66293512
102MARK20.65820779
103SGK10.65692718
104MKNK20.64703389
105NEK60.64231376
106TNK20.63167058
107AURKA0.62759174
108BMPR1B0.60630692
109STK160.60458131
110PBK0.60364133
111ROCK20.60346235
112CSNK1A1L0.58654430
113CSNK1G30.58304383
114CDK11A0.56603455
115ZAK0.55912104
116RET0.53254480
117MYLK0.53157365
118STK380.52892729
119MAP3K20.52345999
120STK240.50941551
121BRAF0.50464834
122PLK40.49744464
123TIE10.48203968
124CAMKK10.47838215
125TTK0.47821498
126WNK10.47692460
127PAK40.46778607
128PAK10.46267234
129STK38L0.45977728
130ADRBK10.45821043
131MAP3K10.45330774
132MAP2K10.44629748
133BRSK10.43830886
134STK110.43455144
135RAF10.43176473
136CDK30.41963546
137PRKCZ0.41037673
138PRKG10.41001835
139WNK40.39936238
140INSRR0.39764842
141MAPKAPK50.39733822
142TYRO30.39329209
143PRKACA0.38646222
144PRKCH0.38229707
145EIF2AK30.36853516
146MAP3K70.36018480
147CDK80.35383035
148CAMKK20.34701524
149CAMK40.34398304

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08304133
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26920771
3Proteasome_Homo sapiens_hsa030502.96273227
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89964203
5Protein export_Homo sapiens_hsa030602.85732114
6GABAergic synapse_Homo sapiens_hsa047272.69246272
7Circadian entrainment_Homo sapiens_hsa047132.66993062
8Glutamatergic synapse_Homo sapiens_hsa047242.57553931
9Morphine addiction_Homo sapiens_hsa050322.55652976
10Olfactory transduction_Homo sapiens_hsa047402.43549269
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.41074438
12Long-term potentiation_Homo sapiens_hsa047202.25989271
13Taste transduction_Homo sapiens_hsa047422.20443675
14Amphetamine addiction_Homo sapiens_hsa050312.19854526
15Collecting duct acid secretion_Homo sapiens_hsa049662.18303667
16Dopaminergic synapse_Homo sapiens_hsa047282.05465367
17Serotonergic synapse_Homo sapiens_hsa047262.01385055
18Ribosome_Homo sapiens_hsa030101.99315959
19Salivary secretion_Homo sapiens_hsa049701.97984696
20Mismatch repair_Homo sapiens_hsa034301.78467674
21Folate biosynthesis_Homo sapiens_hsa007901.76434088
22Insulin secretion_Homo sapiens_hsa049111.72208408
23Long-term depression_Homo sapiens_hsa047301.70763638
24Renin secretion_Homo sapiens_hsa049241.69610924
25Cholinergic synapse_Homo sapiens_hsa047251.68201196
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65390526
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64329830
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61474977
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60696165
30Calcium signaling pathway_Homo sapiens_hsa040201.60545603
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54606379
32Base excision repair_Homo sapiens_hsa034101.52748870
33RNA polymerase_Homo sapiens_hsa030201.52613821
34Gastric acid secretion_Homo sapiens_hsa049711.48580705
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48302111
36Axon guidance_Homo sapiens_hsa043601.42142976
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39942239
38Oxidative phosphorylation_Homo sapiens_hsa001901.38997858
39Cocaine addiction_Homo sapiens_hsa050301.38775274
40Oxytocin signaling pathway_Homo sapiens_hsa049211.37145073
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29411092
42DNA replication_Homo sapiens_hsa030301.28279939
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27832144
44Vibrio cholerae infection_Homo sapiens_hsa051101.27750927
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25665041
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23889006
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23080377
48Pyruvate metabolism_Homo sapiens_hsa006201.21655634
49RNA degradation_Homo sapiens_hsa030181.19003008
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18038704
51GnRH signaling pathway_Homo sapiens_hsa049121.17546428
52Gap junction_Homo sapiens_hsa045401.15519126
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15015257
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14709236
55Biosynthesis of amino acids_Homo sapiens_hsa012301.13602114
56Alzheimers disease_Homo sapiens_hsa050101.13404611
57cAMP signaling pathway_Homo sapiens_hsa040241.13088523
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.12899212
59Carbon metabolism_Homo sapiens_hsa012001.11418274
60Nucleotide excision repair_Homo sapiens_hsa034201.10652604
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09670423
62Melanogenesis_Homo sapiens_hsa049160.99253394
63Pyrimidine metabolism_Homo sapiens_hsa002400.98684487
64Cardiac muscle contraction_Homo sapiens_hsa042600.98504961
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97934013
66ErbB signaling pathway_Homo sapiens_hsa040120.96410128
67Phototransduction_Homo sapiens_hsa047440.96235807
68RNA transport_Homo sapiens_hsa030130.96202738
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94303995
70Basal transcription factors_Homo sapiens_hsa030220.93617019
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.93004783
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90960058
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88129426
74Propanoate metabolism_Homo sapiens_hsa006400.87126006
75Parkinsons disease_Homo sapiens_hsa050120.86473384
76Regulation of autophagy_Homo sapiens_hsa041400.85606602
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80557226
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80013009
79Spliceosome_Homo sapiens_hsa030400.78813038
80Glioma_Homo sapiens_hsa052140.78038799
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77216826
82Estrogen signaling pathway_Homo sapiens_hsa049150.76965554
83Sulfur relay system_Homo sapiens_hsa041220.75417543
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71964656
85Type II diabetes mellitus_Homo sapiens_hsa049300.71857274
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71619315
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67499237
88Rheumatoid arthritis_Homo sapiens_hsa053230.66941111
89Pancreatic secretion_Homo sapiens_hsa049720.66466006
90Ras signaling pathway_Homo sapiens_hsa040140.66264295
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66055415
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64879319
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64800341
94* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64250863
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63912092
96Hippo signaling pathway_Homo sapiens_hsa043900.63770812
97Glutathione metabolism_Homo sapiens_hsa004800.63720576
98Homologous recombination_Homo sapiens_hsa034400.62801388
99Fanconi anemia pathway_Homo sapiens_hsa034600.62376102
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.62219560
101Fatty acid elongation_Homo sapiens_hsa000620.62128592
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58512635
103Dorso-ventral axis formation_Homo sapiens_hsa043200.56993161
104Purine metabolism_Homo sapiens_hsa002300.56165220
105Metabolic pathways_Homo sapiens_hsa011000.56154309
106Vitamin B6 metabolism_Homo sapiens_hsa007500.55322755
107mRNA surveillance pathway_Homo sapiens_hsa030150.55270148
108Choline metabolism in cancer_Homo sapiens_hsa052310.54860688
109Arginine and proline metabolism_Homo sapiens_hsa003300.53887574
110MAPK signaling pathway_Homo sapiens_hsa040100.53532578
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53050295
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.51952437
113Huntingtons disease_Homo sapiens_hsa050160.51942094
114beta-Alanine metabolism_Homo sapiens_hsa004100.50747793
115Ether lipid metabolism_Homo sapiens_hsa005650.50033259
116Steroid biosynthesis_Homo sapiens_hsa001000.50022417
117Cell cycle_Homo sapiens_hsa041100.49430197
118Thyroid hormone synthesis_Homo sapiens_hsa049180.48939116
119Ovarian steroidogenesis_Homo sapiens_hsa049130.48845978
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.48328177
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47314299
122Dilated cardiomyopathy_Homo sapiens_hsa054140.47148837
123African trypanosomiasis_Homo sapiens_hsa051430.46672475
124Wnt signaling pathway_Homo sapiens_hsa043100.46347497
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46162189
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45436823
127Butanoate metabolism_Homo sapiens_hsa006500.44429186
128Salmonella infection_Homo sapiens_hsa051320.43877038
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42693772
130Rap1 signaling pathway_Homo sapiens_hsa040150.42067251
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40945909
132Circadian rhythm_Homo sapiens_hsa047100.40559217
133Selenocompound metabolism_Homo sapiens_hsa004500.39973362
134Pentose phosphate pathway_Homo sapiens_hsa000300.39864226
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37028546
136Phagosome_Homo sapiens_hsa041450.36589337
137Phenylalanine metabolism_Homo sapiens_hsa003600.36539182
138Bile secretion_Homo sapiens_hsa049760.35319516
139Inositol phosphate metabolism_Homo sapiens_hsa005620.35111775
140Peroxisome_Homo sapiens_hsa041460.35056333
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34478116
142Oocyte meiosis_Homo sapiens_hsa041140.33519543
143Tight junction_Homo sapiens_hsa045300.33196115
144Melanoma_Homo sapiens_hsa052180.31308131
145p53 signaling pathway_Homo sapiens_hsa041150.29539352
146Sphingolipid metabolism_Homo sapiens_hsa006000.28895319
147Prion diseases_Homo sapiens_hsa050200.27792464
148Glucagon signaling pathway_Homo sapiens_hsa049220.26280733
149Alcoholism_Homo sapiens_hsa050340.23378040
150Renal cell carcinoma_Homo sapiens_hsa052110.22376694
151Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22357535
152VEGF signaling pathway_Homo sapiens_hsa043700.21347687
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.20850611

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