UBE2E3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.35242578
2nucleobase catabolic process (GO:0046113)4.85036758
3sequestering of actin monomers (GO:0042989)4.49437021
4viral mRNA export from host cell nucleus (GO:0046784)4.39318559
5protein neddylation (GO:0045116)4.05332733
6CENP-A containing nucleosome assembly (GO:0034080)3.99365043
7presynaptic membrane assembly (GO:0097105)3.94105056
8presynaptic membrane organization (GO:0097090)3.73477444
9chromatin remodeling at centromere (GO:0031055)3.73464278
10kinetochore organization (GO:0051383)3.72956235
11kinetochore assembly (GO:0051382)3.66006700
12positive regulation of mitochondrial fission (GO:0090141)3.62586409
13retinal ganglion cell axon guidance (GO:0031290)3.57841475
14telomere maintenance via semi-conservative replication (GO:0032201)3.56662114
15DNA replication-independent nucleosome organization (GO:0034724)3.56629019
16DNA replication-independent nucleosome assembly (GO:0006336)3.56629019
17axonal fasciculation (GO:0007413)3.56539002
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.53036418
19attachment of spindle microtubules to kinetochore (GO:0008608)3.49490598
20cullin deneddylation (GO:0010388)3.46573545
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.44981433
22postsynaptic membrane organization (GO:0001941)3.44514021
23intraciliary transport (GO:0042073)3.42242785
24DNA strand elongation involved in DNA replication (GO:0006271)3.34188128
25protein localization to synapse (GO:0035418)3.32726436
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.30727537
27establishment of mitochondrion localization (GO:0051654)3.28819259
28telomere maintenance via recombination (GO:0000722)3.28153088
29mitotic recombination (GO:0006312)3.27724678
30DNA strand elongation (GO:0022616)3.26135467
31negative regulation of RNA splicing (GO:0033119)3.25167942
32protein deneddylation (GO:0000338)3.25068283
33DNA double-strand break processing (GO:0000729)3.24951832
34mitotic spindle assembly checkpoint (GO:0007094)3.20937894
35neuron recognition (GO:0008038)3.18289584
36* protein K11-linked ubiquitination (GO:0070979)3.18093667
37spindle assembly checkpoint (GO:0071173)3.17702865
38negative regulation of mitotic sister chromatid separation (GO:2000816)3.17479036
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17479036
40negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17479036
41negative regulation of sister chromatid segregation (GO:0033046)3.17479036
427-methylguanosine mRNA capping (GO:0006370)3.17439377
43DNA damage response, detection of DNA damage (GO:0042769)3.16397531
44nonmotile primary cilium assembly (GO:0035058)3.15937783
45RNA capping (GO:0036260)3.15747434
467-methylguanosine RNA capping (GO:0009452)3.15747434
47neuron projection extension involved in neuron projection guidance (GO:1902284)3.15726843
48axon extension involved in axon guidance (GO:0048846)3.15726843
49ganglion development (GO:0061548)3.14776838
50DNA replication initiation (GO:0006270)3.12598770
51DNA ligation (GO:0006266)3.12055721
52histone exchange (GO:0043486)3.10534178
53spliceosomal complex assembly (GO:0000245)3.09183311
54mitotic spindle checkpoint (GO:0071174)3.08477332
55neuron cell-cell adhesion (GO:0007158)3.07886863
56spindle checkpoint (GO:0031577)3.07496085
57negative regulation of chromosome segregation (GO:0051985)3.07343598
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07337451
59DNA topological change (GO:0006265)3.06442904
60histone H2A acetylation (GO:0043968)3.06325209
61DNA replication checkpoint (GO:0000076)3.05565800
62mitotic metaphase plate congression (GO:0007080)3.04819872
63behavioral response to nicotine (GO:0035095)3.03434938
64negative regulation of axon guidance (GO:1902668)3.02815748
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02655307
66olfactory bulb development (GO:0021772)3.01712185
67metaphase plate congression (GO:0051310)3.01136412
68transcription-coupled nucleotide-excision repair (GO:0006283)3.00604667
69regulation of sister chromatid segregation (GO:0033045)2.98292308
70regulation of mitotic sister chromatid separation (GO:0010965)2.98292308
71regulation of mitotic sister chromatid segregation (GO:0033047)2.98292308
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.98071759
73termination of RNA polymerase III transcription (GO:0006386)2.98071759
74chaperone-mediated protein transport (GO:0072321)2.97395215
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95155531
76DNA deamination (GO:0045006)2.92775860
77calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.92714292
78spinal cord association neuron differentiation (GO:0021527)2.92393491
79ribosomal small subunit assembly (GO:0000028)2.91499574
80response to pheromone (GO:0019236)2.89856354
81spliceosomal snRNP assembly (GO:0000387)2.87949032
82negative regulation of mRNA processing (GO:0050686)2.86187267
83telomere maintenance via telomere lengthening (GO:0010833)2.86115963
84cell differentiation involved in metanephros development (GO:0072202)2.84776492
85mRNA splice site selection (GO:0006376)2.83870639
86purine nucleobase biosynthetic process (GO:0009113)2.83569948
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.82856239
88cerebral cortex radially oriented cell migration (GO:0021799)2.82334034
89termination of RNA polymerase II transcription (GO:0006369)2.80951517
90proteasome assembly (GO:0043248)2.80722520
91mitotic sister chromatid cohesion (GO:0007064)2.80711418
92substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79477079
93substrate-independent telencephalic tangential migration (GO:0021826)2.79477079
94deoxyribonucleotide biosynthetic process (GO:0009263)2.77673733
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.77627487
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76140870
97DNA-templated transcription, termination (GO:0006353)2.75688296
98somite development (GO:0061053)2.72880428
99positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.71727813
100mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.71727813
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70425656
102protein polyglutamylation (GO:0018095)2.70349217
103regulation of mRNA splicing, via spliceosome (GO:0048024)2.70192243
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.70000809
105resolution of meiotic recombination intermediates (GO:0000712)2.69795296
106negative regulation of mitosis (GO:0045839)2.68282156
107RNA splicing, via transesterification reactions (GO:0000375)2.68193733
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.68024661
109mRNA splicing, via spliceosome (GO:0000398)2.68024661
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67414202
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67414202
112regulation of development, heterochronic (GO:0040034)2.67341180
113ribonucleoprotein complex disassembly (GO:0032988)2.67235638
114short-term memory (GO:0007614)2.67015395
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66515500
116mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.66310594
117microtubule depolymerization (GO:0007019)2.66034140
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65872315
119intra-S DNA damage checkpoint (GO:0031573)2.64785403
120ATP-dependent chromatin remodeling (GO:0043044)2.64421948
121DNA unwinding involved in DNA replication (GO:0006268)2.64328863
122organelle disassembly (GO:1903008)2.63747112
123poly(A)+ mRNA export from nucleus (GO:0016973)2.63360565
124pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63025190
125GMP metabolic process (GO:0046037)2.62967343
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62797802
127synapse assembly (GO:0007416)2.62629593
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61846126
129transcription elongation from RNA polymerase I promoter (GO:0006362)2.61792420
130forebrain neuron differentiation (GO:0021879)2.61556091
131histone mRNA metabolic process (GO:0008334)2.61417718
132transmission of nerve impulse (GO:0019226)2.60422303
133regulation of chromosome segregation (GO:0051983)2.60354824
134neurotransmitter-gated ion channel clustering (GO:0072578)2.59100385
135neurofilament cytoskeleton organization (GO:0060052)2.55925048
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.55456425
137NADH dehydrogenase complex assembly (GO:0010257)2.55456425
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55456425
139negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55145508
140mismatch repair (GO:0006298)2.54809135
141limb bud formation (GO:0060174)2.54706203
142mesenchymal cell differentiation involved in renal system development (GO:2001012)2.54519888
143mesenchymal cell differentiation involved in kidney development (GO:0072161)2.54519888
144regulation of mitochondrial translation (GO:0070129)2.53512393
145formation of translation preinitiation complex (GO:0001731)2.52745822
146regulation of cilium movement (GO:0003352)2.52296602
147establishment of integrated proviral latency (GO:0075713)2.52063890
148establishment of chromosome localization (GO:0051303)2.52053099
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52045821
150epithelial cilium movement (GO:0003351)2.51737385
151axon extension (GO:0048675)2.51620444
152mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51590274
153regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51377622
154neuronal action potential propagation (GO:0019227)2.51299832
155termination of RNA polymerase I transcription (GO:0006363)2.50910486
156regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50868584
157cytoskeleton-dependent intracellular transport (GO:0030705)2.49835849
158positive regulation of synapse assembly (GO:0051965)2.48443268
159protein localization to cilium (GO:0061512)2.48044877
160vocalization behavior (GO:0071625)2.46130701
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.45810530
162mitochondrion transport along microtubule (GO:0047497)2.45810530
163dendritic spine morphogenesis (GO:0060997)2.45643186
164auditory behavior (GO:0031223)2.45611143
165ATP synthesis coupled proton transport (GO:0015986)2.45279953
166energy coupled proton transport, down electrochemical gradient (GO:0015985)2.45279953
167cholesterol biosynthetic process (GO:0006695)2.42068759
168DNA integration (GO:0015074)2.40048849
169negative chemotaxis (GO:0050919)2.37210869
170cerebral cortex cell migration (GO:0021795)2.36789053
171central nervous system projection neuron axonogenesis (GO:0021952)2.36305562
172hippocampus development (GO:0021766)2.36269643
173establishment of melanosome localization (GO:0032401)2.32338434
174regulation of feeding behavior (GO:0060259)2.32315130
175microtubule-based transport (GO:0010970)2.32109402
176cilium morphogenesis (GO:0060271)2.31981525
177regulation of timing of cell differentiation (GO:0048505)2.30602306
178negative regulation of transcription regulatory region DNA binding (GO:2000678)2.29618513
179protein complex biogenesis (GO:0070271)2.29128599
180neuronal ion channel clustering (GO:0045161)2.28988383
181spinal cord development (GO:0021510)2.28934206
182de novo posttranslational protein folding (GO:0051084)2.28546624
183cell migration in hindbrain (GO:0021535)2.27292159
184mechanosensory behavior (GO:0007638)2.27235158
185neuron fate determination (GO:0048664)2.26466777
186neuron migration (GO:0001764)2.25405236
187positive regulation of gastrulation (GO:2000543)2.24491163
188de novo protein folding (GO:0006458)2.23031201
189melanosome transport (GO:0032402)2.22686069
190epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.22673826
191platelet dense granule organization (GO:0060155)2.21869473
192sterol biosynthetic process (GO:0016126)2.19739891
193cilium assembly (GO:0042384)2.17482092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.17746710
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.91065035
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.36758071
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33954687
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21906350
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.19098156
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.02852584
8IGF1R_20145208_ChIP-Seq_DFB_Human2.87297516
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79202904
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.78935007
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.77710161
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66468671
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.65076931
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62007960
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.56083375
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.36526912
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35806604
18TAF15_26573619_Chip-Seq_HEK293_Human2.29272133
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23300796
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19891749
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13907919
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12762523
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12000452
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10436865
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10303309
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06985371
27VDR_23849224_ChIP-Seq_CD4+_Human2.03569833
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98840744
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97784154
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97574362
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96040183
32* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95657378
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90769853
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89792459
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86990121
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85894413
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84382161
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84095919
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83506183
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81609031
41ELK1_19687146_ChIP-ChIP_HELA_Human1.79876759
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.75485297
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75161963
44XRN2_22483619_ChIP-Seq_HELA_Human1.69505661
45FOXP3_21729870_ChIP-Seq_TREG_Human1.67292085
46P300_19829295_ChIP-Seq_ESCs_Human1.66998969
47VDR_22108803_ChIP-Seq_LS180_Human1.65072885
48GABP_19822575_ChIP-Seq_HepG2_Human1.64867158
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.61139695
50* EWS_26573619_Chip-Seq_HEK293_Human1.60419419
51TTF2_22483619_ChIP-Seq_HELA_Human1.60185965
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60114007
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.58230080
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58034270
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56840152
56DCP1A_22483619_ChIP-Seq_HELA_Human1.56743651
57FUS_26573619_Chip-Seq_HEK293_Human1.56636640
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56630728
59CIITA_25753668_ChIP-Seq_RAJI_Human1.53380404
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50793076
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49245726
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48705930
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46795710
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46551004
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38656043
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37559466
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37080300
68MYC_18940864_ChIP-ChIP_HL60_Human1.36992817
69GBX2_23144817_ChIP-Seq_PC3_Human1.34752503
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34115019
71REST_21632747_ChIP-Seq_MESCs_Mouse1.33618691
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31972908
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.31221290
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.31152450
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30773315
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30092996
77RNF2_27304074_Chip-Seq_NSC_Mouse1.29827396
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.28218884
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28006660
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27973336
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26075117
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24936242
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.24675395
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.24364418
85* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24052803
86* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23266597
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.22370175
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20321898
89IRF1_19129219_ChIP-ChIP_H3396_Human1.19679573
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19054472
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18866436
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18713379
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18073067
94JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17873492
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17634622
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16188764
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.16009050
98* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16008333
99SMAD4_21799915_ChIP-Seq_A2780_Human1.13291442
100* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13044328
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12495292
102AR_21909140_ChIP-Seq_LNCAP_Human1.12079034
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.11987660
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07854517
105SOX9_26525672_Chip-Seq_HEART_Mouse1.07141068
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06149860
107ZNF274_21170338_ChIP-Seq_K562_Hela1.06015893
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05881224
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04974220
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02668251
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01794233
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00853609
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00575190
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98740101
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98424024
116KDM5A_27292631_Chip-Seq_BREAST_Human0.97420347
117* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97153812
118SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96384192
119JUN_21703547_ChIP-Seq_K562_Human0.95809566
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95760920
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95686493
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.95496891
123* AR_25329375_ChIP-Seq_VCAP_Human0.94708228
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94506021
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94210926
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93764293
127EZH2_27294783_Chip-Seq_ESCs_Mouse0.93681350
128* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93637852
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93125376
130EZH2_22144423_ChIP-Seq_EOC_Human0.93105922
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92839236
132* PIAS1_25552417_ChIP-Seq_VCAP_Human0.92802766
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92406891
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.92327699
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92104538
136POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91605529
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91370590
138REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91249437
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.91228110
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91132096
141FLI1_27457419_Chip-Seq_LIVER_Mouse0.89917791
142RUNX2_22187159_ChIP-Seq_PCA_Human0.89782881
143SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89618680
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88713931
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88039491
146FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88009456
147EZH2_27304074_Chip-Seq_ESCs_Mouse0.87898247
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86606624
149EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85827211
150RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85827211
151ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84041316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.53082834
2MP0010094_abnormal_chromosome_stability3.01079869
3MP0003123_paternal_imprinting2.96598879
4MP0003121_genomic_imprinting2.72994523
5MP0008007_abnormal_cellular_replicative2.71900799
6MP0003693_abnormal_embryo_hatching2.68665708
7MP0002938_white_spotting2.46433613
8MP0003122_maternal_imprinting2.44210579
9MP0008877_abnormal_DNA_methylation2.44073383
10MP0008058_abnormal_DNA_repair2.42766903
11MP0001188_hyperpigmentation2.34664493
12MP0000566_synostosis2.33336972
13MP0002102_abnormal_ear_morphology2.31242271
14MP0003111_abnormal_nucleus_morphology2.25942335
15MP0003077_abnormal_cell_cycle2.23895785
16MP0002822_catalepsy2.21244060
17MP0008057_abnormal_DNA_replication2.16087256
18MP0003315_abnormal_perineum_morphology2.10522192
19MP0002653_abnormal_ependyma_morphology2.07444894
20MP0003787_abnormal_imprinting2.07262238
21MP0004859_abnormal_synaptic_plasticity2.02848662
22MP0004957_abnormal_blastocyst_morpholog1.99197284
23MP0008789_abnormal_olfactory_epithelium1.84926503
24MP0000049_abnormal_middle_ear1.83686793
25MP0003786_premature_aging1.80819672
26MP0010030_abnormal_orbit_morphology1.75386203
27MP0004133_heterotaxia1.71855885
28MP0008995_early_reproductive_senescence1.70917828
29MP0004270_analgesia1.67840304
30MP0008932_abnormal_embryonic_tissue1.63047336
31MP0004147_increased_porphyrin_level1.62726350
32MP0001984_abnormal_olfaction1.62648913
33MP0000778_abnormal_nervous_system1.61172082
34MP0002234_abnormal_pharynx_morphology1.54608536
35MP0005187_abnormal_penis_morphology1.52569064
36MP0000955_abnormal_spinal_cord1.47822509
37MP0002163_abnormal_gland_morphology1.47485851
38MP0003938_abnormal_ear_development1.46035391
39MP0000631_abnormal_neuroendocrine_gland1.44746651
40MP0009697_abnormal_copulation1.44434308
41MP0003880_abnormal_central_pattern1.41084032
42MP0002751_abnormal_autonomic_nervous1.40272940
43MP0002736_abnormal_nociception_after1.37470287
44MP0003635_abnormal_synaptic_transmissio1.36970916
45MP0009250_abnormal_appendicular_skeleto1.36620416
46MP0002396_abnormal_hematopoietic_system1.32732599
47MP0006072_abnormal_retinal_apoptosis1.32445988
48MP0003942_abnormal_urinary_system1.30659726
49MP0002557_abnormal_social/conspecific_i1.29336713
50MP0002160_abnormal_reproductive_system1.28667064
51MP0002272_abnormal_nervous_system1.27692459
52MP0004142_abnormal_muscle_tone1.26941772
53MP0001529_abnormal_vocalization1.26246778
54MP0002210_abnormal_sex_determination1.26079391
55MP0004811_abnormal_neuron_physiology1.25902133
56MP0001299_abnormal_eye_distance/1.25000335
57MP0002734_abnormal_mechanical_nocicepti1.23556226
58MP0002063_abnormal_learning/memory/cond1.20579144
59MP0002752_abnormal_somatic_nervous1.19707528
60MP0002095_abnormal_skin_pigmentation1.18388048
61MP0000681_abnormal_thyroid_gland1.18385325
62MP0003937_abnormal_limbs/digits/tail_de1.18151909
63MP0002572_abnormal_emotion/affect_behav1.17931993
64MP0001968_abnormal_touch/_nociception1.17573058
65MP0001486_abnormal_startle_reflex1.17550979
66MP0005645_abnormal_hypothalamus_physiol1.17547507
67MP0002882_abnormal_neuron_morphology1.17406254
68MP0000647_abnormal_sebaceous_gland1.17281734
69MP0005394_taste/olfaction_phenotype1.17037291
70MP0005499_abnormal_olfactory_system1.17037291
71MP0005379_endocrine/exocrine_gland_phen1.16910369
72MP0009046_muscle_twitch1.14899538
73MP0002735_abnormal_chemical_nociception1.14741995
74MP0002638_abnormal_pupillary_reflex1.14307408
75MP0002152_abnormal_brain_morphology1.14271210
76MP0009379_abnormal_foot_pigmentation1.12690335
77MP0009745_abnormal_behavioral_response1.11475797
78MP0002067_abnormal_sensory_capabilities1.09686685
79MP0003136_yellow_coat_color1.09597450
80MP0003385_abnormal_body_wall1.08105187
81MP0003755_abnormal_palate_morphology1.07273464
82MP0005171_absent_coat_pigmentation1.05135333
83MP0003943_abnormal_hepatobiliary_system1.05042462
84MP0003119_abnormal_digestive_system1.04083876
85MP0002009_preneoplasia1.03982140
86MP0002177_abnormal_outer_ear1.03233822
87MP0001293_anophthalmia1.03223067
88MP0003861_abnormal_nervous_system1.02847425
89MP0001145_abnormal_male_reproductive1.01656242
90MP0001286_abnormal_eye_development1.01499113
91MP0003567_abnormal_fetal_cardiomyocyte0.98962991
92MP0002233_abnormal_nose_morphology0.98247604
93MP0002733_abnormal_thermal_nociception0.97033192
94MP0001970_abnormal_pain_threshold0.96126483
95MP0004808_abnormal_hematopoietic_stem0.95177577
96MP0005389_reproductive_system_phenotype0.94700621
97MP0005084_abnormal_gallbladder_morpholo0.94205578
98MP0003115_abnormal_respiratory_system0.94153257
99MP0000537_abnormal_urethra_morphology0.93926271
100MP0003935_abnormal_craniofacial_develop0.93788600
101MP0002064_seizures0.93623664
102MP0000653_abnormal_sex_gland0.90461874
103MP0005386_behavior/neurological_phenoty0.90285272
104MP0004924_abnormal_behavior0.90285272
105MP0005551_abnormal_eye_electrophysiolog0.90263171
106MP0001905_abnormal_dopamine_level0.89784504
107MP0002116_abnormal_craniofacial_bone0.89608831
108MP0002249_abnormal_larynx_morphology0.89066270
109MP0001929_abnormal_gametogenesis0.88944033
110MP0005391_vision/eye_phenotype0.88774618
111MP0005195_abnormal_posterior_eye0.88755613
112MP0000015_abnormal_ear_pigmentation0.88746504
113MP0006276_abnormal_autonomic_nervous0.88645005
114MP0003890_abnormal_embryonic-extraembry0.88559480
115MP0000026_abnormal_inner_ear0.88397469
116MP0002114_abnormal_axial_skeleton0.87626286
117MP0001119_abnormal_female_reproductive0.87134463
118MP0002697_abnormal_eye_size0.86954241
119MP0001697_abnormal_embryo_size0.86915546
120MP0002085_abnormal_embryonic_tissue0.86673662
121MP0000350_abnormal_cell_proliferation0.86162374
122MP0002932_abnormal_joint_morphology0.85807027
123MP0000534_abnormal_ureter_morphology0.85243289
124MP0004145_abnormal_muscle_electrophysio0.85141824
125MP0005248_abnormal_Harderian_gland0.84644589
126MP0000678_abnormal_parathyroid_gland0.84623399
127MP0001485_abnormal_pinna_reflex0.83876793
128MP0001270_distended_abdomen0.82342936
129MP0002184_abnormal_innervation0.81705315
130MP0009053_abnormal_anal_canal0.81567849
131MP0000751_myopathy0.80121619
132MP0002081_perinatal_lethality0.79680223
133MP0005646_abnormal_pituitary_gland0.78985416
134MP0002282_abnormal_trachea_morphology0.77010183
135MP0005380_embryogenesis_phenotype0.75379314
136MP0001672_abnormal_embryogenesis/_devel0.75379314
137MP0004134_abnormal_chest_morphology0.74968371
138MP0005423_abnormal_somatic_nervous0.74885126
139MP0003221_abnormal_cardiomyocyte_apopto0.74669126
140MP0002066_abnormal_motor_capabilities/c0.74528384
141MP0000313_abnormal_cell_death0.74269744
142MP0005503_abnormal_tendon_morphology0.73470406
143MP0005253_abnormal_eye_physiology0.73299894
144MP0004885_abnormal_endolymph0.73110386
145MP0001177_atelectasis0.70555512
146MP0001186_pigmentation_phenotype0.69851379
147MP0005174_abnormal_tail_pigmentation0.69247597
148MP0006054_spinal_hemorrhage0.69196628
149MP0003718_maternal_effect0.68953462
150MP0000428_abnormal_craniofacial_morphol0.68554975

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.52155348
2Birth length less than 3rd percentile (HP:0003561)3.23734831
3Abnormality of the heme biosynthetic pathway (HP:0010472)2.95866483
4Abnormal lung lobation (HP:0002101)2.93002092
5Myokymia (HP:0002411)2.84985229
6Vaginal atresia (HP:0000148)2.83973471
7Genital tract atresia (HP:0001827)2.81907211
8Retinal dysplasia (HP:0007973)2.81599722
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80933795
10Polyphagia (HP:0002591)2.80135066
11Abnormality of the labia minora (HP:0012880)2.80094104
12Patellar aplasia (HP:0006443)2.78205370
13Nephroblastoma (Wilms tumor) (HP:0002667)2.75938100
14Aplastic anemia (HP:0001915)2.74817714
15Acute necrotizing encephalopathy (HP:0006965)2.71288770
16Type I transferrin isoform profile (HP:0003642)2.67511557
17Aplasia/Hypoplasia of the patella (HP:0006498)2.66291314
18Embryonal renal neoplasm (HP:0011794)2.64575159
19Septo-optic dysplasia (HP:0100842)2.62968473
20Colon cancer (HP:0003003)2.60642209
21Chromsome breakage (HP:0040012)2.58856172
22Hypothermia (HP:0002045)2.58169050
23True hermaphroditism (HP:0010459)2.55994910
24Hyperglycinemia (HP:0002154)2.54298166
25Specific learning disability (HP:0001328)2.52591255
26Acute encephalopathy (HP:0006846)2.46795961
27Limb dystonia (HP:0002451)2.44287431
28Irregular epiphyses (HP:0010582)2.38586734
29Abnormal mitochondria in muscle tissue (HP:0008316)2.37423839
30Capillary hemangiomas (HP:0005306)2.36056022
31Nephronophthisis (HP:0000090)2.31268692
32Broad foot (HP:0001769)2.31073862
33Meckel diverticulum (HP:0002245)2.29289091
34Anophthalmia (HP:0000528)2.28373908
35Hypoplasia of the brainstem (HP:0002365)2.27848165
36Aplasia/Hypoplasia of the brainstem (HP:0007362)2.27848165
37Drooling (HP:0002307)2.27007873
38Optic nerve hypoplasia (HP:0000609)2.26918411
39Supernumerary spleens (HP:0009799)2.25925224
40Diastasis recti (HP:0001540)2.25836486
41Pancreatic fibrosis (HP:0100732)2.23874235
42Flat capital femoral epiphysis (HP:0003370)2.23354205
43Shoulder girdle muscle weakness (HP:0003547)2.22200850
44Abnormality of the musculature of the pelvis (HP:0001469)2.22123670
45Abnormality of the hip-girdle musculature (HP:0001445)2.22123670
46Type 2 muscle fiber atrophy (HP:0003554)2.21939811
47Volvulus (HP:0002580)2.20117240
48Postaxial hand polydactyly (HP:0001162)2.19980281
49Ectopic kidney (HP:0000086)2.18917404
50Abnormality of the ileum (HP:0001549)2.18739784
51Progressive macrocephaly (HP:0004481)2.15155058
52Short middle phalanx of the 5th finger (HP:0004220)2.15060273
53Decreased testicular size (HP:0008734)2.13165527
54Embryonal neoplasm (HP:0002898)2.12675185
55Pachygyria (HP:0001302)2.12444330
56Mitochondrial inheritance (HP:0001427)2.12213254
57Intestinal atresia (HP:0011100)2.12164041
58Protruding tongue (HP:0010808)2.11684880
59Medulloblastoma (HP:0002885)2.11617823
60Sclerocornea (HP:0000647)2.11595639
61Abnormality of the corticospinal tract (HP:0002492)2.11366598
62Postaxial foot polydactyly (HP:0001830)2.10069087
63Abnormality of the lower motor neuron (HP:0002366)2.09108269
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.05893590
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05893590
66Duodenal stenosis (HP:0100867)2.03729701
67Small intestinal stenosis (HP:0012848)2.03729701
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02597419
69Adrenal hypoplasia (HP:0000835)2.00639291
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.99596959
71Abnormality of the columella (HP:0009929)1.99064204
72Impulsivity (HP:0100710)1.97513384
73Occipital encephalocele (HP:0002085)1.97007089
74Exercise-induced muscle cramps (HP:0003710)1.96877160
75Aplasia/Hypoplasia of the sternum (HP:0006714)1.96825983
76Excessive salivation (HP:0003781)1.96092518
77Absent septum pellucidum (HP:0001331)1.95583423
78Pancreatic cysts (HP:0001737)1.95118235
79Abnormality of the preputium (HP:0100587)1.94582970
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.94097832
81Asymmetry of the thorax (HP:0001555)1.93114454
82Muscle fiber atrophy (HP:0100295)1.91480726
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91198661
84Short 4th metacarpal (HP:0010044)1.91198661
85Abnormality of chromosome stability (HP:0003220)1.91008747
86Gait imbalance (HP:0002141)1.90846447
87Oligodactyly (hands) (HP:0001180)1.90562118
88Increased hepatocellular lipid droplets (HP:0006565)1.90478797
89Rimmed vacuoles (HP:0003805)1.89762769
90Abnormality of the phalanges of the hallux (HP:0010057)1.89649054
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88878783
92Pendular nystagmus (HP:0012043)1.88833518
93Micropenis (HP:0000054)1.88647455
94Abnormality of the renal collecting system (HP:0004742)1.88510063
95Reduced antithrombin III activity (HP:0001976)1.88313102
96Amyotrophic lateral sclerosis (HP:0007354)1.87415951
97Impaired vibration sensation in the lower limbs (HP:0002166)1.86870304
98Vitreoretinal degeneration (HP:0000655)1.86098524
99Abnormality of the renal medulla (HP:0100957)1.85967067
100Bifid tongue (HP:0010297)1.85620372
1013-Methylglutaconic aciduria (HP:0003535)1.84891079
102Myelodysplasia (HP:0002863)1.84762277
103Congenital primary aphakia (HP:0007707)1.84469974
104Medial flaring of the eyebrow (HP:0010747)1.84454506
105Abnormal hair whorl (HP:0010721)1.83534930
106Abnormality of the phalanges of the 5th finger (HP:0004213)1.82437044
107Failure to thrive in infancy (HP:0001531)1.82264802
108Narrow forehead (HP:0000341)1.81799455
109Reticulocytopenia (HP:0001896)1.81113453
110Increased CSF lactate (HP:0002490)1.79960468
111Nephrogenic diabetes insipidus (HP:0009806)1.79641607
112Aplasia/Hypoplasia of the lens (HP:0008063)1.79132059
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.78982545
114Abnormality of the intervertebral disk (HP:0005108)1.78227574
115Gonadotropin excess (HP:0000837)1.78180616
116Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78164554
117Amblyopia (HP:0000646)1.77913470
118Renal hypoplasia (HP:0000089)1.77409958
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76127884
120Abnormality of alanine metabolism (HP:0010916)1.76127884
121Hyperalaninemia (HP:0003348)1.76127884
122Heterochromia iridis (HP:0001100)1.75520207
123Increased serum pyruvate (HP:0003542)1.75141101
124Poor suck (HP:0002033)1.74520980
125Abnormality of the duodenum (HP:0002246)1.74447006
126Atresia of the external auditory canal (HP:0000413)1.74368896
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73858549
128Abnormal protein N-linked glycosylation (HP:0012347)1.73858549
129Abnormal protein glycosylation (HP:0012346)1.73858549
130Abnormal glycosylation (HP:0012345)1.73858549
13111 pairs of ribs (HP:0000878)1.73842678
132Preaxial hand polydactyly (HP:0001177)1.73513473
133Tracheomalacia (HP:0002779)1.73291762
134Aganglionic megacolon (HP:0002251)1.73250598
135Lissencephaly (HP:0001339)1.73101415
136Focal motor seizures (HP:0011153)1.72934588
137Hypoplastic pelvis (HP:0008839)1.72805250
138Anencephaly (HP:0002323)1.71974456
139Oligodactyly (HP:0012165)1.71458043
140Hepatoblastoma (HP:0002884)1.70676658
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.69572153
142Broad-based gait (HP:0002136)1.69380275
143Renal Fanconi syndrome (HP:0001994)1.68923662
144Molar tooth sign on MRI (HP:0002419)1.68691564
145Abnormality of midbrain morphology (HP:0002418)1.68691564
146Abnormality of the nasolacrimal system (HP:0000614)1.68413044
147Triphalangeal thumb (HP:0001199)1.68345747
148Urinary urgency (HP:0000012)1.67827603
149Abnormal respiratory epithelium morphology (HP:0012253)1.67616310
150Abnormal respiratory motile cilium morphology (HP:0005938)1.67616310
151Breast hypoplasia (HP:0003187)1.67382843
152Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67124581
153Focal seizures (HP:0007359)1.66523763
154Tubulointerstitial nephritis (HP:0001970)1.65936479
155Lipid accumulation in hepatocytes (HP:0006561)1.65903743
156Atonic seizures (HP:0010819)1.65596339
157Neoplasm of the adrenal cortex (HP:0100641)1.65497705
158Abnormal number of erythroid precursors (HP:0012131)1.65127081
159Methylmalonic acidemia (HP:0002912)1.63122173
160Hepatocellular necrosis (HP:0001404)1.62932484
161Type II lissencephaly (HP:0007260)1.62630659
162Growth hormone deficiency (HP:0000824)1.62463752
163Abnormality of the anterior horn cell (HP:0006802)1.61698843
164Degeneration of anterior horn cells (HP:0002398)1.61698843
165Fibular hypoplasia (HP:0003038)1.61288045
166Abnormality of incisor morphology (HP:0011063)1.60991345
167Poor coordination (HP:0002370)1.60070780
168Thyroid-stimulating hormone excess (HP:0002925)1.59981030
169Abnormality of the lacrimal duct (HP:0011481)1.59739370
170Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.59679598
171Polymicrogyria (HP:0002126)1.59637178
172Midline defect of the nose (HP:0004122)1.59582954
173Short tibia (HP:0005736)1.59547142
174Dandy-Walker malformation (HP:0001305)1.59522919
175Horseshoe kidney (HP:0000085)1.58963344
176Acute lymphatic leukemia (HP:0006721)1.57661709
177Hemivertebrae (HP:0002937)1.57606846
178Hypoplastic iliac wings (HP:0002866)1.57568056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK193.59453079
2TRIM283.30399321
3MKNK13.25362746
4BUB12.90791797
5ACVR1B2.82413054
6MKNK22.78458377
7BRSK22.66334828
8CDC72.61041219
9WEE12.45670199
10STK162.44172932
11CCNB12.38370453
12CASK2.34854806
13DYRK32.22884786
14ERBB32.19323050
15MAP4K22.12946942
16SRPK12.10067165
17TAOK22.05990447
18PLK42.01985104
19ZAK2.00615095
20VRK11.97019749
21TNIK1.96480798
22SIK31.91918803
23EIF2AK11.85808638
24PLK31.82264395
25CDK81.79515522
26PRPF4B1.78136788
27MAP3K121.73007829
28MAPK131.61424752
29DYRK21.60906869
30BRSK11.60655775
31MARK11.59228010
32BCKDK1.58682098
33LIMK11.57988598
34MAP2K71.52351476
35EPHA31.39160155
36BCR1.37037722
37CDK31.23293493
38CHEK21.23038159
39PASK1.22671919
40FRK1.21073689
41NUAK11.19064121
42KSR11.17833360
43TESK11.16723759
44PNCK1.16156328
45YES11.14091519
46PLK11.11090146
47NTRK21.06406696
48PAK31.05760123
49STK241.02935588
50BRD40.99266212
51MAP2K40.98526355
52ATR0.97076730
53NEK20.94325045
54PRKCG0.93071795
55VRK20.88774896
56TLK10.88728734
57BMPR1B0.87623074
58NEK10.86003447
59TGFBR10.85532175
60CAMKK20.85338656
61CDK70.82273502
62AURKB0.81110027
63EPHB20.80740665
64EIF2AK30.80282932
65DYRK1A0.79663695
66AKT30.78755892
67FGFR20.78413808
68TIE10.75741806
69GRK10.74486272
70CDK150.74422467
71UHMK10.71642864
72EIF2AK20.69461461
73TSSK60.69051107
74PHKG20.64306258
75PHKG10.64306258
76CDK50.64040107
77PAK60.64021738
78CSNK1G30.63897822
79PKN10.63783050
80NTRK30.61551621
81WNK30.61254127
82AURKA0.60593123
83CAMK2A0.59797218
84PRKCE0.59541717
85CLK10.58169848
86TTK0.57142206
87PLK20.55508543
88ATM0.53941529
89BMPR20.53426404
90DAPK10.52537629
91MUSK0.52495335
92STK38L0.52351864
93TESK20.52010086
94PBK0.51819020
95BRAF0.51585854
96CSNK2A10.50911344
97CDK10.49748330
98MINK10.49695187
99RPS6KA50.49443500
100MAP3K60.48089854
101TEC0.48085406
102CHEK10.48035256
103OBSCN0.47904154
104NME20.46957553
105ADRBK20.46083885
106CSNK1A1L0.44819319
107EPHA40.44585066
108PINK10.43637299
109KIT0.43243030
110CAMK2B0.41271428
111DYRK1B0.40871693
112SGK20.40594791
113PRKD30.40122501
114FLT30.39973798
115CSNK1G20.39774213
116MAP3K40.39391918
117* CDK20.38587814
118MAPKAPK50.38300713
119SGK2230.38170213
120SGK4940.38170213
121CSNK1E0.37611693
122ADRBK10.36912162
123CDK11A0.36804141
124PRKACA0.36367225
125NTRK10.35204845
126CDK180.34644168
127CSNK1A10.33851273
128ERBB20.33189670
129GRK50.32427083
130PRKG10.31430720
131CSNK1G10.31202246
132CAMK40.30134312
133MAP3K50.30108113
134NME10.29528113
135MAPK150.28907722
136RPS6KA40.28708719
137LMTK20.28601236
138INSRR0.27139287
139CDK140.25905286
140ILK0.24710866
141CSNK2A20.24623172
142STK30.23530493

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.14982065
2Mismatch repair_Homo sapiens_hsa034303.57127154
3Spliceosome_Homo sapiens_hsa030403.27247099
4RNA polymerase_Homo sapiens_hsa030203.24724258
5Cell cycle_Homo sapiens_hsa041102.95563909
6Base excision repair_Homo sapiens_hsa034102.94895037
7Nucleotide excision repair_Homo sapiens_hsa034202.83427198
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63154851
9Homologous recombination_Homo sapiens_hsa034402.57333100
10Basal transcription factors_Homo sapiens_hsa030222.53978599
11Steroid biosynthesis_Homo sapiens_hsa001002.53322033
12Proteasome_Homo sapiens_hsa030502.40041729
13Pyrimidine metabolism_Homo sapiens_hsa002402.36486090
14RNA transport_Homo sapiens_hsa030132.33968604
15Protein export_Homo sapiens_hsa030602.32107988
16Fanconi anemia pathway_Homo sapiens_hsa034602.23665642
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22588711
18mRNA surveillance pathway_Homo sapiens_hsa030152.14130290
19Ribosome_Homo sapiens_hsa030101.98366897
20RNA degradation_Homo sapiens_hsa030181.90095223
21Cardiac muscle contraction_Homo sapiens_hsa042601.74680263
22Fatty acid elongation_Homo sapiens_hsa000621.56449393
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55346278
24Purine metabolism_Homo sapiens_hsa002301.52060883
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51149316
26Oocyte meiosis_Homo sapiens_hsa041141.49932425
27Propanoate metabolism_Homo sapiens_hsa006401.46882648
28Non-homologous end-joining_Homo sapiens_hsa034501.39421981
29Synaptic vesicle cycle_Homo sapiens_hsa047211.31354622
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26881271
31* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20116796
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19460357
33Cocaine addiction_Homo sapiens_hsa050301.17056921
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15711357
35p53 signaling pathway_Homo sapiens_hsa041151.14945020
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14493562
37Pyruvate metabolism_Homo sapiens_hsa006201.13094765
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11188103
39Butanoate metabolism_Homo sapiens_hsa006501.05634137
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01662907
41N-Glycan biosynthesis_Homo sapiens_hsa005101.01233340
42Alcoholism_Homo sapiens_hsa050340.94615102
43Hedgehog signaling pathway_Homo sapiens_hsa043400.92276298
44Epstein-Barr virus infection_Homo sapiens_hsa051690.92137323
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.92133378
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91113449
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90518482
48Biosynthesis of amino acids_Homo sapiens_hsa012300.90258844
49Collecting duct acid secretion_Homo sapiens_hsa049660.88069990
50Basal cell carcinoma_Homo sapiens_hsa052170.87425536
51Nicotine addiction_Homo sapiens_hsa050330.86979798
52Peroxisome_Homo sapiens_hsa041460.85080859
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85014053
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84365769
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84202572
56Wnt signaling pathway_Homo sapiens_hsa043100.83625468
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83195822
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83002607
59Colorectal cancer_Homo sapiens_hsa052100.81421782
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.80645471
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80160746
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78660662
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78244297
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77983382
65Carbon metabolism_Homo sapiens_hsa012000.76876209
66Systemic lupus erythematosus_Homo sapiens_hsa053220.75931245
67Hippo signaling pathway_Homo sapiens_hsa043900.75789905
68Herpes simplex infection_Homo sapiens_hsa051680.75022898
69Huntingtons disease_Homo sapiens_hsa050160.74053973
70HTLV-I infection_Homo sapiens_hsa051660.69801202
71Regulation of autophagy_Homo sapiens_hsa041400.69682686
72Axon guidance_Homo sapiens_hsa043600.69250984
73Endometrial cancer_Homo sapiens_hsa052130.68918502
74Thyroid cancer_Homo sapiens_hsa052160.67087090
75Circadian rhythm_Homo sapiens_hsa047100.67018128
76Phototransduction_Homo sapiens_hsa047440.65204427
77Parkinsons disease_Homo sapiens_hsa050120.64849959
78Arginine and proline metabolism_Homo sapiens_hsa003300.64300844
79Metabolic pathways_Homo sapiens_hsa011000.62707384
80Melanoma_Homo sapiens_hsa052180.60394650
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60230550
82Fatty acid metabolism_Homo sapiens_hsa012120.60140789
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59225791
84Vibrio cholerae infection_Homo sapiens_hsa051100.59185821
85Serotonergic synapse_Homo sapiens_hsa047260.56300270
86One carbon pool by folate_Homo sapiens_hsa006700.55754285
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54473914
88TGF-beta signaling pathway_Homo sapiens_hsa043500.54427883
89beta-Alanine metabolism_Homo sapiens_hsa004100.54361730
90Taste transduction_Homo sapiens_hsa047420.52952696
91MicroRNAs in cancer_Homo sapiens_hsa052060.52638105
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52427907
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52279664
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51995700
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49040709
96Morphine addiction_Homo sapiens_hsa050320.48712429
97Glutathione metabolism_Homo sapiens_hsa004800.48249617
98Arachidonic acid metabolism_Homo sapiens_hsa005900.47762369
99Sulfur relay system_Homo sapiens_hsa041220.47617627
100Dopaminergic synapse_Homo sapiens_hsa047280.47615240
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46813955
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44937296
103Long-term depression_Homo sapiens_hsa047300.44792371
104Viral carcinogenesis_Homo sapiens_hsa052030.44316384
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43410108
106Insulin secretion_Homo sapiens_hsa049110.43071819
107Prostate cancer_Homo sapiens_hsa052150.41903831
108Tight junction_Homo sapiens_hsa045300.41839092
109Long-term potentiation_Homo sapiens_hsa047200.40743247
110Circadian entrainment_Homo sapiens_hsa047130.40083796
111Pathways in cancer_Homo sapiens_hsa052000.39924512
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39782347
113Glutamatergic synapse_Homo sapiens_hsa047240.39670047
114FoxO signaling pathway_Homo sapiens_hsa040680.39458984
115Amphetamine addiction_Homo sapiens_hsa050310.39263829
116Dilated cardiomyopathy_Homo sapiens_hsa054140.38925826
117Hepatitis B_Homo sapiens_hsa051610.38216442
118Gap junction_Homo sapiens_hsa045400.37922461
119Vitamin B6 metabolism_Homo sapiens_hsa007500.37020709
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.36920973
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35824078
122Notch signaling pathway_Homo sapiens_hsa043300.34268901
123Olfactory transduction_Homo sapiens_hsa047400.32963742
124Non-small cell lung cancer_Homo sapiens_hsa052230.32941107
125Oxidative phosphorylation_Homo sapiens_hsa001900.32524600
126Melanogenesis_Homo sapiens_hsa049160.32409598
127Small cell lung cancer_Homo sapiens_hsa052220.30703618
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30602521
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30040102
130Glioma_Homo sapiens_hsa052140.29384713
131Alzheimers disease_Homo sapiens_hsa050100.25206575
132MAPK signaling pathway_Homo sapiens_hsa040100.22016250
133GABAergic synapse_Homo sapiens_hsa047270.21876007
134Renal cell carcinoma_Homo sapiens_hsa052110.20557662
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19007927
136Folate biosynthesis_Homo sapiens_hsa007900.18818925
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18779861
138Ras signaling pathway_Homo sapiens_hsa040140.18703893
139Cholinergic synapse_Homo sapiens_hsa047250.18505485

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