UBE2F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protein neddylation (GO:0045116)5.01249171
2neutrophil activation involved in immune response (GO:0002283)4.97017482
3response to peptidoglycan (GO:0032494)4.89495911
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54601913
5positive regulation of interferon-alpha production (GO:0032727)4.19188437
6positive regulation of chemokine biosynthetic process (GO:0045080)4.14283234
7DNA deamination (GO:0045006)4.09145517
8regulation of chemokine biosynthetic process (GO:0045073)4.08658845
9thrombin receptor signaling pathway (GO:0070493)4.00469014
10Arp2/3 complex-mediated actin nucleation (GO:0034314)4.00412214
11regulation of interferon-alpha production (GO:0032647)3.96528825
12hydrogen peroxide biosynthetic process (GO:0050665)3.86905536
13natural killer cell mediated cytotoxicity (GO:0042267)3.85593269
14natural killer cell mediated immunity (GO:0002228)3.85593269
15reactive oxygen species biosynthetic process (GO:1903409)3.81867834
16regulation of fever generation (GO:0031620)3.77593332
17lipopolysaccharide-mediated signaling pathway (GO:0031663)3.75836901
18positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.73089409
19granulocyte activation (GO:0036230)3.71048181
20response to muramyl dipeptide (GO:0032495)3.66981887
21immunoglobulin mediated immune response (GO:0016064)3.64593273
22positive regulation of heat generation (GO:0031652)3.58991469
23neutrophil activation (GO:0042119)3.58550143
24cytidine metabolic process (GO:0046087)3.57751792
25cytidine catabolic process (GO:0006216)3.57751792
26cytidine deamination (GO:0009972)3.57751792
27regulation of T-helper 1 cell differentiation (GO:0045625)3.54080901
28superoxide anion generation (GO:0042554)3.52111730
29cellular response to interferon-beta (GO:0035458)3.52043285
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50686981
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.50686981
32modulation by symbiont of host immune response (GO:0052553)3.50686981
33positive regulation by symbiont of host defense response (GO:0052509)3.50686981
34modulation by symbiont of host defense response (GO:0052031)3.50686981
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50686981
36respiratory burst (GO:0045730)3.49456947
37regulation of activation of Janus kinase activity (GO:0010533)3.45456048
38platelet dense granule organization (GO:0060155)3.44942112
39response to interferon-beta (GO:0035456)3.29929108
40actin nucleation (GO:0045010)3.29214376
41myeloid dendritic cell differentiation (GO:0043011)3.28914962
42defense response to protozoan (GO:0042832)3.26939655
43neutrophil mediated immunity (GO:0002446)3.25149754
44leukocyte mediated cytotoxicity (GO:0001909)3.22684567
45myeloid leukocyte mediated immunity (GO:0002444)3.22256213
46positive regulation of interleukin-12 production (GO:0032735)3.22106986
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21435972
48myeloid dendritic cell activation (GO:0001773)3.18115100
49NIK/NF-kappaB signaling (GO:0038061)3.18051802
50pyrimidine nucleoside catabolic process (GO:0046135)3.16597663
51leukocyte degranulation (GO:0043299)3.14362433
52regulation of platelet activation (GO:0010543)3.13685266
53type I interferon signaling pathway (GO:0060337)3.12672961
54cellular response to type I interferon (GO:0071357)3.12672961
55regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.11792542
56negative regulation of viral genome replication (GO:0045071)3.11706964
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.10537227
58regulation of chronic inflammatory response (GO:0002676)3.09340852
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08939740
60cellular response to exogenous dsRNA (GO:0071360)3.08765280
61response to type I interferon (GO:0034340)3.06693277
62regulation of regulatory T cell differentiation (GO:0045589)3.04127953
63negative regulation of interleukin-17 production (GO:0032700)3.03606397
64pyrimidine ribonucleoside catabolic process (GO:0046133)3.02893444
65positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.02266328
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00980368
67B cell mediated immunity (GO:0019724)3.00286219
68negative regulation of growth of symbiont in host (GO:0044130)2.99352694
69negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.99352694
70modulation of growth of symbiont involved in interaction with host (GO:0044144)2.99352694
71regulation of growth of symbiont in host (GO:0044126)2.99352694
72positive regulation of macrophage differentiation (GO:0045651)2.99035914
73proteasome assembly (GO:0043248)2.98298427
74cellular response to zinc ion (GO:0071294)2.97974750
75autophagic vacuole fusion (GO:0000046)2.97791364
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.96857518
77interferon-gamma-mediated signaling pathway (GO:0060333)2.95293571
78regulation of RIG-I signaling pathway (GO:0039535)2.95087039
79lipoxygenase pathway (GO:0019372)2.94549497
80positive regulation of mast cell activation (GO:0033005)2.93268966
81response to protozoan (GO:0001562)2.92255123
82negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91893535
83positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.89752984
84monocyte chemotaxis (GO:0002548)2.88493645
85signal peptide processing (GO:0006465)2.87841153
86positive regulation of interferon-beta production (GO:0032728)2.87678499
87purinergic nucleotide receptor signaling pathway (GO:0035590)2.86989768
88regulation of vitamin D biosynthetic process (GO:0060556)2.86873593
89mitochondrial calcium ion transport (GO:0006851)2.85974347
90negative regulation of T cell apoptotic process (GO:0070233)2.85683025
91macrophage activation involved in immune response (GO:0002281)2.82766739
92negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81648048
93regulation of platelet aggregation (GO:0090330)2.81266725
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81015635
95negative regulation of cell killing (GO:0031342)2.81015635
96positive regulation of interleukin-17 production (GO:0032740)2.80680627
97purine-containing compound salvage (GO:0043101)2.76878017
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74634586
99negative regulation of myeloid cell apoptotic process (GO:0033033)2.74289709
100positive regulation of monocyte chemotaxis (GO:0090026)2.74250241
101positive regulation of cAMP-mediated signaling (GO:0043950)2.72913095
102regulation of interleukin-12 production (GO:0032655)2.72066033
103positive regulation of gamma-delta T cell activation (GO:0046645)2.72056967
104myeloid cell activation involved in immune response (GO:0002275)2.71857830
105leukocyte migration involved in inflammatory response (GO:0002523)2.71697199
106antigen processing and presentation of endogenous antigen (GO:0019883)2.71614075
107antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.70987036
108positive regulation of alpha-beta T cell proliferation (GO:0046641)2.70601488
109leukocyte aggregation (GO:0070486)2.70126334
110eosinophil chemotaxis (GO:0048245)2.68727476
111regulation of immunoglobulin secretion (GO:0051023)2.68521083
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.66560588
113regulation of interleukin-12 biosynthetic process (GO:0045075)2.66197984
114G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.66059056
115regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65980667
116response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65848535
117response to host immune response (GO:0052572)2.65848535
118response to interferon-alpha (GO:0035455)2.65727559
119positive regulation of B cell differentiation (GO:0045579)2.65624331
120organelle membrane fusion (GO:0090174)2.65377103
121pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.64527489
122sequestering of actin monomers (GO:0042989)2.63233736
123negative regulation of calcium ion transport into cytosol (GO:0010523)2.62745789
124regulation of heat generation (GO:0031650)2.62200436
125polyamine biosynthetic process (GO:0006596)2.62197583
126cellular response to virus (GO:0098586)2.61180136
127T-helper 1 type immune response (GO:0042088)2.60580865
128eosinophil migration (GO:0072677)2.60438661
129positive regulation of natural killer cell mediated immunity (GO:0002717)2.60410578
130regulation of alpha-beta T cell proliferation (GO:0046640)2.60058453
131regulation of interferon-beta biosynthetic process (GO:0045357)2.59702398
132positive regulation of DNA recombination (GO:0045911)2.58990556
133negative regulation of heart rate (GO:0010459)2.58881861
134detection of molecule of bacterial origin (GO:0032490)2.57551031
135regulation of natural killer cell mediated immunity (GO:0002715)2.57109153
136regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.57109153
137regulation of mononuclear cell migration (GO:0071675)2.56704344
138regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56554545
139positive regulation of T-helper cell differentiation (GO:0045624)2.56331953
140positive regulation of type 2 immune response (GO:0002830)2.56005013
141positive regulation of humoral immune response (GO:0002922)2.55610448
142regulation of mast cell activation (GO:0033003)2.54831937
143regulation of interleukin-17 production (GO:0032660)2.54620790
144negative regulation of interleukin-12 production (GO:0032695)2.54336150
145antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54293682
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54293682
147negative regulation of mast cell activation (GO:0033004)2.54011720
148adenosine receptor signaling pathway (GO:0001973)2.53525168
149regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.53054462
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.48995290
151natural killer cell activation involved in immune response (GO:0002323)2.47104473
152positive regulation of interleukin-10 production (GO:0032733)2.46963113
153negative regulation of thymocyte apoptotic process (GO:0070244)2.46641636
154positive regulation of B cell mediated immunity (GO:0002714)2.46569179
155positive regulation of immunoglobulin mediated immune response (GO:0002891)2.46569179
156mast cell activation (GO:0045576)2.44652271
157positive regulation of isotype switching (GO:0045830)2.44169789
158positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.43372004
159positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.40096320
160interferon-gamma production (GO:0032609)2.39725344
161adenosine metabolic process (GO:0046085)2.39065589
162cellular response to interleukin-15 (GO:0071350)2.38395803
163purinergic receptor signaling pathway (GO:0035587)2.37903488
164negative regulation of T cell mediated immunity (GO:0002710)2.37827759
165deoxyribonucleotide catabolic process (GO:0009264)2.37443261
166regulation of inflammatory response to antigenic stimulus (GO:0002861)2.33425856
167deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.29203820
168purine nucleotide salvage (GO:0032261)2.28792903
169regulation of gamma-delta T cell activation (GO:0046643)2.28143000
170phagosome maturation (GO:0090382)2.27652070
171regulation of mast cell degranulation (GO:0043304)2.27044697
172regulation of MHC class II biosynthetic process (GO:0045346)2.26334071
173adaptation of signaling pathway (GO:0023058)2.25869234
174deoxyribose phosphate catabolic process (GO:0046386)2.25356436
175positive regulation of lymphocyte migration (GO:2000403)2.24848133
176regulation of leukocyte mediated cytotoxicity (GO:0001910)2.23026517
177L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.22634660
178regulation of T cell tolerance induction (GO:0002664)2.22542942
179response to interleukin-15 (GO:0070672)2.22217739
180platelet aggregation (GO:0070527)2.22024714
181regulation of integrin-mediated signaling pathway (GO:2001044)2.21707092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.96229500
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.56690999
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.22920779
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.12014128
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25476395
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05480573
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.99425447
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83441698
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68037138
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60444190
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59056921
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58492488
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58374748
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50038354
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49508388
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38434367
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31574588
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21958532
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19805205
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.18041674
21* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15094736
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11622587
23SPI1_23547873_ChIP-Seq_NB4_Human2.07738401
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.01505385
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98548812
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93442196
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.92334514
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87862536
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87822636
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78749468
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.78336948
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78045644
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75068752
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73238412
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70411671
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.67136907
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66656215
38ELK1_19687146_ChIP-ChIP_HELA_Human1.63524235
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62578810
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57348745
41VDR_23849224_ChIP-Seq_CD4+_Human1.54591955
42* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52951938
43DCP1A_22483619_ChIP-Seq_HELA_Human1.52843754
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.52809120
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50111459
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49115507
47* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43791495
48MYB_26560356_Chip-Seq_TH2_Human1.42887662
49HTT_18923047_ChIP-ChIP_STHdh_Human1.41367140
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41210359
51* RUNX_20019798_ChIP-Seq_JUKART_Human1.40165374
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39475383
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.37918464
54SPI1_23127762_ChIP-Seq_K562_Human1.37195630
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.37131680
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36782864
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.35965412
58GATA1_19941826_ChIP-Seq_K562_Human1.34841057
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34801511
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33854689
61* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33504555
62* PU_27001747_Chip-Seq_BMDM_Mouse1.29918067
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29810511
64* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29337404
65* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28492882
66* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28133900
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27824799
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27470019
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27319451
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27296189
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27249744
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25533067
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21689002
74* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21098715
75* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18571200
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18258853
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17562602
78GATA1_22025678_ChIP-Seq_K562_Human1.15509947
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15508804
80GATA2_19941826_ChIP-Seq_K562_Human1.14372947
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14003373
82MYB_26560356_Chip-Seq_TH1_Human1.13091173
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12789671
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12195615
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.11796604
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11513507
87STAT1_20625510_ChIP-Seq_HELA_Human1.10194313
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.09555339
89* MAF_26560356_Chip-Seq_TH1_Human1.07097361
90GATA3_26560356_Chip-Seq_TH2_Human1.05222659
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05174915
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04673399
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04211061
94VDR_24763502_ChIP-Seq_THP-1_Human1.02788564
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01038900
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00539599
97UTX_26944678_Chip-Seq_JUKART_Human1.00428836
98NANOG_20526341_ChIP-Seq_ESCs_Human0.99875007
99NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99770569
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99551753
101SCL_19346495_ChIP-Seq_HPC-7_Human0.99278673
102* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98238121
103VDR_22108803_ChIP-Seq_LS180_Human0.98077218
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96568584
105* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96040114
106GATA3_21878914_ChIP-Seq_MCF-7_Human0.95789223
107* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95604021
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95159129
109* FOXP3_21729870_ChIP-Seq_TREG_Human0.94819436
110TFEB_21752829_ChIP-Seq_HELA_Human0.94559345
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94232787
112THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94028615
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94007803
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93989933
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93040166
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92848641
117GATA3_27048872_Chip-Seq_THYMUS_Human0.92694684
118TP53_22573176_ChIP-Seq_HFKS_Human0.92017583
119* AR_20517297_ChIP-Seq_VCAP_Human0.91656477
120* GATA3_26560356_Chip-Seq_TH1_Human0.90965732
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90922141
122* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90852112
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89528943
124FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89479806
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89177758
126VDR_24787735_ChIP-Seq_THP-1_Human0.88319776
127E2F7_22180533_ChIP-Seq_HELA_Human0.88026650
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87489410
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.87320229
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86436352
131* GABP_19822575_ChIP-Seq_HepG2_Human0.85260383
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84916604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.85800744
2MP0009785_altered_susceptibility_to4.26184240
3MP0003436_decreased_susceptibility_to3.60289996
4MP0002148_abnormal_hypersensitivity_rea3.48835368
5MP0005671_abnormal_response_to3.31705664
6MP0005000_abnormal_immune_tolerance2.91953657
7MP0005025_abnormal_response_to2.88286970
8MP0002419_abnormal_innate_immunity2.87431677
9MP0006082_CNS_inflammation2.87175756
10MP0000685_abnormal_immune_system2.77361953
11MP0008004_abnormal_stomach_pH2.67338082
12MP0003724_increased_susceptibility_to2.63033242
13MP0003186_abnormal_redox_activity2.43608793
14MP0002452_abnormal_antigen_presenting2.40121523
15MP0001853_heart_inflammation2.37167040
16MP0001790_abnormal_immune_system2.33479385
17MP0005387_immune_system_phenotype2.33479385
18MP0002723_abnormal_immune_serum2.32596947
19MP0001800_abnormal_humoral_immune2.17408160
20MP0001819_abnormal_immune_cell2.12577368
21MP0002420_abnormal_adaptive_immunity2.07687392
22MP0005464_abnormal_platelet_physiology2.04048894
23MP0003656_abnormal_erythrocyte_physiolo1.98824776
24MP0009764_decreased_sensitivity_to1.97971749
25MP0001845_abnormal_inflammatory_respons1.85648252
26MP0003303_peritoneal_inflammation1.84784016
27MP0001533_abnormal_skeleton_physiology1.84686806
28MP0009333_abnormal_splenocyte_physiolog1.84550737
29MP0003806_abnormal_nucleotide_metabolis1.83014715
30MP0008469_abnormal_protein_level1.82113911
31MP0005083_abnormal_biliary_tract1.80352321
32MP0002837_dystrophic_cardiac_calcinosis1.78388583
33MP0002006_tumorigenesis1.66990221
34MP0004510_myositis1.64712175
35MP0002405_respiratory_system_inflammati1.64626087
36MP0003646_muscle_fatigue1.61637095
37MP0000858_altered_metastatic_potential1.60917681
38MP0000465_gastrointestinal_hemorrhage1.59557402
39MP0000343_altered_response_to1.57802934
40MP0004947_skin_inflammation1.56197293
41MP0002398_abnormal_bone_marrow1.51543845
42MP0000716_abnormal_immune_system1.51247045
43MP0010155_abnormal_intestine_physiology1.48377781
44MP0003191_abnormal_cellular_cholesterol1.44941665
45MP0003448_altered_tumor_morphology1.42480646
46MP0001545_abnormal_hematopoietic_system1.42000419
47MP0005397_hematopoietic_system_phenotyp1.42000419
48MP0005058_abnormal_lysosome_morphology1.40362931
49MP0006054_spinal_hemorrhage1.37080041
50MP0002429_abnormal_blood_cell1.30307503
51MP0005410_abnormal_fertilization1.27662222
52MP0000689_abnormal_spleen_morphology1.26544778
53MP0003300_gastrointestinal_ulcer1.23527784
54MP0002138_abnormal_hepatobiliary_system1.19121771
55MP0003866_abnormal_defecation1.17854800
56MP0002722_abnormal_immune_system1.15227652
57MP0003195_calcinosis1.15096914
58MP0000230_abnormal_systemic_arterial1.14311577
59MP0002736_abnormal_nociception_after1.14099381
60MP0009763_increased_sensitivity_to1.10819677
61MP0003075_altered_response_to1.10180809
62MP0004147_increased_porphyrin_level1.08469920
63MP0002163_abnormal_gland_morphology1.08305652
64MP0005174_abnormal_tail_pigmentation1.07887493
65MP0008260_abnormal_autophagy1.06351365
66MP0004084_abnormal_cardiac_muscle1.04926723
67MP0002277_abnormal_respiratory_mucosa1.03827326
68MP0004036_abnormal_muscle_relaxation1.03564802
69MP0002166_altered_tumor_susceptibility1.03528205
70MP0000372_irregular_coat_pigmentation0.99772436
71MP0006035_abnormal_mitochondrial_morpho0.99631229
72MP0002933_joint_inflammation0.99212429
73MP0008872_abnormal_physiological_respon0.98961064
74MP0005167_abnormal_blood-brain_barrier0.97796630
75MP0002998_abnormal_bone_remodeling0.97796144
76MP0005084_abnormal_gallbladder_morpholo0.97069896
77MP0009697_abnormal_copulation0.96858289
78MP0005310_abnormal_salivary_gland0.96365005
79MP0005636_abnormal_mineral_homeostasis0.96017347
80MP0005075_abnormal_melanosome_morpholog0.95306945
81MP0005166_decreased_susceptibility_to0.95215216
82MP0000569_abnormal_digit_pigmentation0.92922925
83MP0000490_abnormal_crypts_of0.92831332
84MP0003638_abnormal_response/metabolism_0.92409016
85MP0004782_abnormal_surfactant_physiolog0.92401604
86MP0004215_abnormal_myocardial_fiber0.92381182
87MP0001764_abnormal_homeostasis0.92234537
88MP0002139_abnormal_hepatobiliary_system0.90354554
89MP0005164_abnormal_response_to0.89805580
90MP0005319_abnormal_enzyme/_coenzyme0.88228825
91MP0001666_abnormal_nutrient_absorption0.88070482
92MP0005390_skeleton_phenotype0.86815265
93MP0001663_abnormal_digestive_system0.86799449
94MP0003172_abnormal_lysosome_physiology0.85457813
95MP0001542_abnormal_bone_strength0.84259579
96MP0005646_abnormal_pituitary_gland0.83575812
97MP0003828_pulmonary_edema0.81735358
98MP0003763_abnormal_thymus_physiology0.81629277
99MP0005451_abnormal_body_composition0.81028885
100MP0000371_diluted_coat_color0.80726810
101MP0000015_abnormal_ear_pigmentation0.79797217
102MP0003183_abnormal_peptide_metabolism0.79644242
103MP0001905_abnormal_dopamine_level0.79006320
104MP0000703_abnormal_thymus_morphology0.78315033
105MP0001968_abnormal_touch/_nociception0.77344233
106MP0005165_increased_susceptibility_to0.76679702
107MP0001851_eye_inflammation0.76285916
108MP0004808_abnormal_hematopoietic_stem0.75562215
109MP0005408_hypopigmentation0.72612927
110MP0010386_abnormal_urinary_bladder0.72532911
111MP0003693_abnormal_embryo_hatching0.71834001
112MP0000358_abnormal_cell_content/0.71753670
113MP0000249_abnormal_blood_vessel0.70420272
114MP0002693_abnormal_pancreas_physiology0.69384798
115MP0001881_abnormal_mammary_gland0.69251351
116MP0008775_abnormal_heart_ventricle0.68842916
117MP0004142_abnormal_muscle_tone0.68729952
118MP0002638_abnormal_pupillary_reflex0.68308961
119MP0002254_reproductive_system_inflammat0.67989410
120MP0002132_abnormal_respiratory_system0.67917620
121MP0005584_abnormal_enzyme/coenzyme_acti0.67243121
122MP0002876_abnormal_thyroid_physiology0.66343530
123MP0009840_abnormal_foam_cell0.66286518
124MP0002332_abnormal_exercise_endurance0.65440354
125MP0009765_abnormal_xenobiotic_induced0.65178054
126MP0003453_abnormal_keratinocyte_physiol0.64846723
127MP0000598_abnormal_liver_morphology0.63226920
128MP0006036_abnormal_mitochondrial_physio0.62500099
129MP0002019_abnormal_tumor_incidence0.62358484

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.90728308
2Recurrent bacterial skin infections (HP:0005406)5.59236305
3Prolonged bleeding time (HP:0003010)5.52746235
4Eczematoid dermatitis (HP:0000976)5.43918772
5Elevated erythrocyte sedimentation rate (HP:0003565)5.35488683
6Recurrent gram-negative bacterial infections (HP:0005420)4.83253523
7Myositis (HP:0100614)4.33408984
8Mediastinal lymphadenopathy (HP:0100721)4.18209720
9Orchitis (HP:0100796)4.07753778
10Optic neuritis (HP:0100653)4.02285968
11Retrobulbar optic neuritis (HP:0100654)4.02285968
12Increased mean platelet volume (HP:0011877)3.96712460
13Abnormality of macrophages (HP:0004311)3.91770113
14Menorrhagia (HP:0000132)3.88679940
15Abnormal platelet volume (HP:0011876)3.88145711
16Autoimmune thrombocytopenia (HP:0001973)3.39784549
17Increased IgM level (HP:0003496)3.39438543
18Recurrent skin infections (HP:0001581)3.39347881
19Acute necrotizing encephalopathy (HP:0006965)3.38060893
20Generalized aminoaciduria (HP:0002909)3.23493208
21Obstructive lung disease (HP:0006536)3.21200436
22Chronic obstructive pulmonary disease (HP:0006510)3.21200436
23Abnormal mitochondria in muscle tissue (HP:0008316)3.13177452
24Vasculitis (HP:0002633)3.12180716
25Gingivitis (HP:0000230)2.96071864
26Encephalitis (HP:0002383)2.96031817
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.94887449
28Recurrent fungal infections (HP:0002841)2.93688123
29Stomatitis (HP:0010280)2.93665901
30Nausea (HP:0002018)2.90890322
31Impaired platelet aggregation (HP:0003540)2.90325861
32Abnormal platelet function (HP:0011869)2.90325861
33Urticaria (HP:0001025)2.89074208
34Hyperlipoproteinemia (HP:0010980)2.88074168
35Acute encephalopathy (HP:0006846)2.83567124
36Poor head control (HP:0002421)2.81922146
37Progressive macrocephaly (HP:0004481)2.81276811
38Abnormality of lateral ventricle (HP:0030047)2.73155691
39Basal ganglia calcification (HP:0002135)2.72793325
40Tetraparesis (HP:0002273)2.71776427
41Pulmonary infiltrates (HP:0002113)2.70001171
42Vacuolated lymphocytes (HP:0001922)2.69253363
43Paralysis (HP:0003470)2.62976066
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.61468366
45Systemic lupus erythematosus (HP:0002725)2.60231429
46Abnormal pupillary function (HP:0007686)2.59541409
47Gastrointestinal infarctions (HP:0005244)2.58956123
48Recurrent pneumonia (HP:0006532)2.57637477
49Recurrent viral infections (HP:0004429)2.56412624
50Petechiae (HP:0000967)2.53985855
51Increased CSF lactate (HP:0002490)2.52726784
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51487136
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51487136
54Thrombocytosis (HP:0001894)2.50385981
55Keratoconjunctivitis sicca (HP:0001097)2.49532030
56Abnormality of alanine metabolism (HP:0010916)2.42445059
57Hyperalaninemia (HP:0003348)2.42445059
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42445059
59Anorexia (HP:0002039)2.42320485
60Abnormality of T cells (HP:0002843)2.41772023
61Vertebral compression fractures (HP:0002953)2.41342678
62Leukocytosis (HP:0001974)2.40932866
63IgG deficiency (HP:0004315)2.40584576
64Spontaneous hematomas (HP:0007420)2.40253427
65Hypergammaglobulinemia (HP:0010702)2.38702727
66Periodontitis (HP:0000704)2.38215371
67Autoimmune hemolytic anemia (HP:0001890)2.36842317
68Exertional dyspnea (HP:0002875)2.32942271
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.31679385
70Hemoptysis (HP:0002105)2.31486321
71Keratoconjunctivitis (HP:0001096)2.31444037
72Dyschromatopsia (HP:0007641)2.31378385
73Neoplasm of head and neck (HP:0012288)2.29838119
74Esophageal neoplasm (HP:0100751)2.29838119
75Increased serum ferritin (HP:0003281)2.28425871
76Recurrent cutaneous fungal infections (HP:0011370)2.28105489
77Chronic mucocutaneous candidiasis (HP:0002728)2.28105489
78Interstitial pulmonary disease (HP:0006530)2.27115110
79Arterial thrombosis (HP:0004420)2.26069918
80Abnormality of liposaccharide metabolism (HP:0010968)2.24933285
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.24933285
82Abnormality of glycolipid metabolism (HP:0010969)2.24933285
83Meningitis (HP:0001287)2.24734566
84Increased cerebral lipofuscin (HP:0011813)2.23868518
85Episodic fever (HP:0001954)2.19689223
86Abnormality of the pericardium (HP:0001697)2.19210963
87Increased intramyocellular lipid droplets (HP:0012240)2.18908297
88Pustule (HP:0200039)2.18090023
89Eosinophilia (HP:0001880)2.17716941
90Aplastic anemia (HP:0001915)2.16602325
91Gingival bleeding (HP:0000225)2.16218429
92Albinism (HP:0001022)2.11960171
93Hepatosplenomegaly (HP:0001433)2.11648574
94Abnormality of T cell number (HP:0011839)2.08674972
95Abnormality of the pleura (HP:0002103)2.08534171
96Joint swelling (HP:0001386)2.04877963
97Granulocytopenia (HP:0001913)2.03833682
98Increased hepatocellular lipid droplets (HP:0006565)2.02692786
99Peritonitis (HP:0002586)2.02447122
100Poikilocytosis (HP:0004447)2.01733700
101Irregular epiphyses (HP:0010582)2.01478221
102Recurrent lower respiratory tract infections (HP:0002783)2.01129050
103Reduced antithrombin III activity (HP:0001976)2.01080987
104Osteomyelitis (HP:0002754)1.99866641
105Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99713872
106Premature loss of primary teeth (HP:0006323)1.97832101
107Prolonged neonatal jaundice (HP:0006579)1.97327632
1083-Methylglutaconic aciduria (HP:0003535)1.97159609
109Lactic acidosis (HP:0003128)1.96880062
110Cerebral edema (HP:0002181)1.95197261
111Arthropathy (HP:0003040)1.95163503
112Posterior subcapsular cataract (HP:0007787)1.95126967
113Purpura (HP:0000979)1.94292005
114Myocardial infarction (HP:0001658)1.93666361
115Epistaxis (HP:0000421)1.93325361
116Axonal loss (HP:0003447)1.93235638
117Gangrene (HP:0100758)1.92871508
118Severe visual impairment (HP:0001141)1.91307025
119Cellulitis (HP:0100658)1.91046503
120Chronic otitis media (HP:0000389)1.90103208
121Acute hepatic failure (HP:0006554)1.89563222
122Arthralgia (HP:0002829)1.89347499
123Abnormality of iron homeostasis (HP:0011031)1.88490122
124Dicarboxylic aciduria (HP:0003215)1.88353927
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88353927
126Hepatic necrosis (HP:0002605)1.87634890
127Mitochondrial inheritance (HP:0001427)1.87416009
128Lipid accumulation in hepatocytes (HP:0006561)1.87359290
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85995350
130Severe combined immunodeficiency (HP:0004430)1.85355492
131Panhypogammaglobulinemia (HP:0003139)1.84806688
132Abnormality of the prostate (HP:0008775)1.84184862
133Joint hemorrhage (HP:0005261)1.84103251
134Hypoproteinemia (HP:0003075)1.83566791
135Increased muscle lipid content (HP:0009058)1.82085890
136Tinnitus (HP:0000360)1.81507173
137Conjunctival telangiectasia (HP:0000524)1.81477719
138Renal Fanconi syndrome (HP:0001994)1.80778829
139Polyneuropathy (HP:0001271)1.80721871
140Renal cortical cysts (HP:0000803)1.79435047
141Dysostosis multiplex (HP:0000943)1.79338989
142Abnormality of eosinophils (HP:0001879)1.79295815
143Hepatocellular necrosis (HP:0001404)1.78886475
144Amyloidosis (HP:0011034)1.78463467
145Progressive neurologic deterioration (HP:0002344)1.77691058
146Pathologic fracture (HP:0002756)1.77686076
147T lymphocytopenia (HP:0005403)1.74875392
148Cutaneous photosensitivity (HP:0000992)1.72065841
149Cerebral palsy (HP:0100021)1.70050270
150Abnormality of transition element cation homeostasis (HP:0011030)1.70026838
151Abnormality of T cell physiology (HP:0011840)1.69224636
152Thick nail (HP:0001805)1.69205569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.31682973
2IRAK33.57210287
3MAP4K23.48444851
4PBK3.41953982
5TBK13.40331627
6NME22.90756818
7EIF2AK12.85030378
8PIM22.78309552
9IRAK42.72462260
10RIPK42.65368659
11BLK2.62619708
12IKBKE2.49239104
13IKBKB2.42287492
14TXK2.25256619
15TYK22.11826360
16JAK32.06890814
17SIK31.96373803
18MST41.71718172
19EIF2AK21.68072676
20TESK11.62438175
21NEK91.57399595
22MAP4K11.54109256
23ABL21.51849123
24TNK21.48068577
25ACVR1B1.47659883
26FES1.45866058
27ZAP701.44913819
28RPS6KA41.44875019
29ITK1.43030037
30ERN11.41554080
31CHUK1.41180128
32STK161.40537064
33EIF2AK31.38120150
34ARAF1.35458845
35NUAK11.32988542
36BCKDK1.29805028
37BMPR21.26961784
38MAP2K31.26595062
39KIT1.26238885
40BMPR1B1.24798102
41YES11.23025014
42MAPKAPK31.20400499
43MAP3K121.20152574
44MAP3K111.17583873
45ILK1.13748163
46GRK51.11968939
47JAK11.11429371
48FGR1.08084730
49TEC1.06921674
50CDK191.05169402
51GRK11.03822782
52STK41.01480489
53ERBB31.00826131
54PTK2B0.99689628
55PIM10.99389135
56SYK0.98469370
57TLK10.97150938
58GRK60.96932037
59MAP3K30.95471186
60BUB10.90910183
61PRKCQ0.88220662
62PIK3CG0.86644902
63ADRBK20.84544397
64PLK40.83798067
65PAK10.81977486
66BTK0.81854041
67SRPK10.81792507
68TRIM280.80708767
69TGFBR20.79302496
70CSF1R0.77837411
71PINK10.77547356
72IRAK10.76162551
73MAP3K50.75353630
74LYN0.75111760
75LCK0.71380503
76MARK30.71070085
77TRPM70.68694613
78KDR0.68426178
79PRKCD0.68166993
80STK240.67426567
81CAMKK20.62972647
82LIMK10.61042647
83DAPK10.60474573
84FLT30.58912312
85PRKG20.57725388
86ADRBK10.57705004
87ZAK0.56943566
88BRSK20.56176708
89TAOK30.55581237
90JAK20.54755724
91MYLK0.54739981
92GRK70.54539587
93NLK0.54236107
94TAOK20.54009854
95MOS0.53577805
96FGFR30.52623044
97DAPK20.52363841
98MAPKAPK20.52094289
99TAOK10.51775571
100EPHA20.51701540
101MST1R0.51422964
102BCR0.50416444
103CDK80.50365324
104MAP3K130.47788352
105RPS6KA50.46260483
106TIE10.45806640
107PDK20.45729338
108IGF1R0.44190838
109BRAF0.43991622
110HCK0.43262452
111WNK40.43210751
112CSK0.42133786
113VRK10.41891901
114PLK20.41213677
115EPHA30.40564116
116MAP2K60.39810474
117STK100.39410404
118WEE10.37787058
119ABL10.37081609
120CSNK1G30.36177974
121OBSCN0.36032739
122DAPK30.34107350
123IRAK20.34066684
124PAK40.34063210
125TGFBR10.34031130
126MUSK0.33690292
127TESK20.32481978
128BMX0.31691073
129MATK0.31295873
130DYRK30.31056468
131PDK10.30089228
132FGFR40.29601386

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.74367804
2Proteasome_Homo sapiens_hsa030503.34085764
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.29714903
4Legionellosis_Homo sapiens_hsa051342.97412406
5Leishmaniasis_Homo sapiens_hsa051402.89914647
6Allograft rejection_Homo sapiens_hsa053302.89223304
7Sulfur metabolism_Homo sapiens_hsa009202.69248892
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.47749375
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42185065
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.31775922
11Type I diabetes mellitus_Homo sapiens_hsa049402.20609000
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13562057
13Rheumatoid arthritis_Homo sapiens_hsa053232.05052772
14Malaria_Homo sapiens_hsa051442.00002403
15Measles_Homo sapiens_hsa051621.97100954
16Pertussis_Homo sapiens_hsa051331.95470764
17Platelet activation_Homo sapiens_hsa046111.94548586
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92703671
19Influenza A_Homo sapiens_hsa051641.81946075
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.76104929
21Staphylococcus aureus infection_Homo sapiens_hsa051501.73026982
22Protein export_Homo sapiens_hsa030601.70627494
23TNF signaling pathway_Homo sapiens_hsa046681.62325784
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60018699
25Tuberculosis_Homo sapiens_hsa051521.59218723
26Herpes simplex infection_Homo sapiens_hsa051681.58448734
27African trypanosomiasis_Homo sapiens_hsa051431.51735326
28Asthma_Homo sapiens_hsa053101.50692382
29Osteoclast differentiation_Homo sapiens_hsa043801.45853278
30Salmonella infection_Homo sapiens_hsa051321.44418028
31Ribosome_Homo sapiens_hsa030101.40713035
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38173359
33Phagosome_Homo sapiens_hsa041451.36749219
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28338847
35Hematopoietic cell lineage_Homo sapiens_hsa046401.26730678
36Regulation of autophagy_Homo sapiens_hsa041401.25381161
37Antigen processing and presentation_Homo sapiens_hsa046121.25065965
38Shigellosis_Homo sapiens_hsa051311.18955210
39Autoimmune thyroid disease_Homo sapiens_hsa053201.17832053
40Apoptosis_Homo sapiens_hsa042101.17283408
41Oxidative phosphorylation_Homo sapiens_hsa001901.15947042
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13563234
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11938567
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10303851
45Toxoplasmosis_Homo sapiens_hsa051451.10029984
46Folate biosynthesis_Homo sapiens_hsa007901.09514088
47Fatty acid elongation_Homo sapiens_hsa000621.06975638
48Lysosome_Homo sapiens_hsa041421.01096222
49Nitrogen metabolism_Homo sapiens_hsa009100.99463856
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97252507
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96036954
52Viral myocarditis_Homo sapiens_hsa054160.95890761
53One carbon pool by folate_Homo sapiens_hsa006700.95160646
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93766081
55Cardiac muscle contraction_Homo sapiens_hsa042600.92052063
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91682391
57Epstein-Barr virus infection_Homo sapiens_hsa051690.90844545
58Parkinsons disease_Homo sapiens_hsa050120.90462535
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.88550050
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83823992
61Primary immunodeficiency_Homo sapiens_hsa053400.81472381
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80132272
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79949725
64Phototransduction_Homo sapiens_hsa047440.78512569
65Hepatitis B_Homo sapiens_hsa051610.77335310
66Other glycan degradation_Homo sapiens_hsa005110.74962689
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74860190
68Hepatitis C_Homo sapiens_hsa051600.70955415
69B cell receptor signaling pathway_Homo sapiens_hsa046620.67333732
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65363978
71DNA replication_Homo sapiens_hsa030300.64329945
72Pyrimidine metabolism_Homo sapiens_hsa002400.63819245
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63268494
74Chemokine signaling pathway_Homo sapiens_hsa040620.61760976
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60227156
76RNA polymerase_Homo sapiens_hsa030200.59149217
77Purine metabolism_Homo sapiens_hsa002300.58922415
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58543114
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57718223
80Endocytosis_Homo sapiens_hsa041440.57502342
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57212607
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56291157
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55999675
84Complement and coagulation cascades_Homo sapiens_hsa046100.54396914
85Huntingtons disease_Homo sapiens_hsa050160.52367478
86Steroid biosynthesis_Homo sapiens_hsa001000.51209682
87Alzheimers disease_Homo sapiens_hsa050100.50504020
88Linoleic acid metabolism_Homo sapiens_hsa005910.50380763
89Pentose phosphate pathway_Homo sapiens_hsa000300.50208347
90Collecting duct acid secretion_Homo sapiens_hsa049660.50156087
91Peroxisome_Homo sapiens_hsa041460.47178917
92Glutathione metabolism_Homo sapiens_hsa004800.47163048
93p53 signaling pathway_Homo sapiens_hsa041150.44553071
94Mismatch repair_Homo sapiens_hsa034300.44200297
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43245918
96Base excision repair_Homo sapiens_hsa034100.42055829
97Caffeine metabolism_Homo sapiens_hsa002320.41870567
98Basal transcription factors_Homo sapiens_hsa030220.39612800
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38855634
100Prion diseases_Homo sapiens_hsa050200.38333980
101Metabolic pathways_Homo sapiens_hsa011000.38193378
102Homologous recombination_Homo sapiens_hsa034400.38191540
103Arachidonic acid metabolism_Homo sapiens_hsa005900.37368781
104T cell receptor signaling pathway_Homo sapiens_hsa046600.35167969
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.34723639
106Sulfur relay system_Homo sapiens_hsa041220.33677236
107Vibrio cholerae infection_Homo sapiens_hsa051100.33142245
108Acute myeloid leukemia_Homo sapiens_hsa052210.32678520
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.32390012
110Amoebiasis_Homo sapiens_hsa051460.32020960
111Systemic lupus erythematosus_Homo sapiens_hsa053220.31790177
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31001623
113Galactose metabolism_Homo sapiens_hsa000520.30478961
114Fat digestion and absorption_Homo sapiens_hsa049750.30075657
115Synaptic vesicle cycle_Homo sapiens_hsa047210.28470641
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.28215385
117Glycerolipid metabolism_Homo sapiens_hsa005610.27763573
118Viral carcinogenesis_Homo sapiens_hsa052030.27038599
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.26912622
120Tryptophan metabolism_Homo sapiens_hsa003800.26507058
121Fructose and mannose metabolism_Homo sapiens_hsa000510.26491588
122Selenocompound metabolism_Homo sapiens_hsa004500.26221171
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25837170
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25387732
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24905552
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24576203

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