ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.66201122
2	proteasome assembly (GO:0043248)	4.83955729
3	cytidine deamination (GO:0009972)	4.74517796
4	cytidine metabolic process (GO:0046087)	4.74517796
5	cytidine catabolic process (GO:0006216)	4.74517796
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.43160456
7	DNA deamination (GO:0045006)	4.36968123
8	regulation of response to tumor cell (GO:0002834)	4.35671186
9	positive regulation of response to tumor cell (GO:0002836)	4.35671186
10	positive regulation of immune response to tumor cell (GO:0002839)	4.35671186
11	regulation of immune response to tumor cell (GO:0002837)	4.35671186
12	cullin deneddylation (GO:0010388)	4.11096569
13	lactate metabolic process (GO:0006089)	4.04200913
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.99432781
15	rRNA methylation (GO:0031167)	3.96127054
16	protein deneddylation (GO:0000338)	3.91235428
17	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.72551644
18	rRNA modification (GO:0000154)	3.59284272
19	negative regulation of thymocyte apoptotic process (GO:0070244)	3.31711214
20	positive regulation of T cell cytokine production (GO:0002726)	3.16590838
21	protein maturation by protein folding (GO:0022417)	3.16418256
22	regulation of translational termination (GO:0006449)	3.11867159
23	interferon-gamma production (GO:0032609)	3.10496154
24	DNA catabolic process, exonucleolytic (GO:0000738)	3.06943744
25	regulation of cellular amino acid metabolic process (GO:0006521)	3.04807776
26	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.03513030
27	autophagic vacuole fusion (GO:0000046)	3.02645989
28	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.00883419
29	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.00207508
30	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.99206097
31	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.97301512
32	organelle membrane fusion (GO:0090174)	2.97295262
33	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.96031480
34	pseudouridine synthesis (GO:0001522)	2.95516179
35	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.93896849
36	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.92668325
37	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.92053720
38	regulation of T cell chemotaxis (GO:0010819)	2.91418328
39	positive regulation of T cell chemotaxis (GO:0010820)	2.91418328
40	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.91056597
41	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.91056597
42	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.91056597
43	ribosome assembly (GO:0042255)	2.90908367
44	regulation of meiosis I (GO:0060631)	2.90633095
45	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.90583111
46	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.90583111
47	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.90439048
48	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.86511856
49	negative regulation of ligase activity (GO:0051352)	2.86511856
50	nucleobase biosynthetic process (GO:0046112)	2.83793222
51	positive regulation of granulocyte differentiation (GO:0030854)	2.79956731
52	regulation of translation in response to stress (GO:0043555)	2.79415800
53	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.79385047
54	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.79385047
55	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.78944779
56	DNA double-strand break processing (GO:0000729)	2.78326820
57	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.75734200
58	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.75652128
59	branched-chain amino acid catabolic process (GO:0009083)	2.75562989
60	negative regulation of execution phase of apoptosis (GO:1900118)	2.74457716
61	regulation of alpha-beta T cell proliferation (GO:0046640)	2.74334847
62	phospholipid homeostasis (GO:0055091)	2.70872285
63	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.69391646
64	heparin metabolic process (GO:0030202)	2.68055487
65	heparin biosynthetic process (GO:0030210)	2.68055487
66	regulation of lymphocyte chemotaxis (GO:1901623)	2.62834097
67	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.62631516
68	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.62631516
69	isotype switching (GO:0045190)	2.62631516
70	regulation of T cell mediated cytotoxicity (GO:0001914)	2.60014861
71	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.59274174
72	purine nucleobase biosynthetic process (GO:0009113)	2.57079569
73	positive regulation of ligase activity (GO:0051351)	2.56058933
74	negative regulation of T cell apoptotic process (GO:0070233)	2.55780731
75	regulation of integrin-mediated signaling pathway (GO:2001044)	2.54916924
76	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.53647051
77	positive regulation of cell cycle arrest (GO:0071158)	2.52195237
78	7-methylguanosine mRNA capping (GO:0006370)	2.51674147
79	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.50735507
80	pyrimidine nucleoside catabolic process (GO:0046135)	2.47116657
81	NADPH regeneration (GO:0006740)	2.46266523
82	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.44984532
83	positive regulation of cell killing (GO:0031343)	2.44195078
84	positive regulation of DNA recombination (GO:0045911)	2.43519952
85	7-methylguanosine RNA capping (GO:0009452)	2.43212570
86	RNA capping (GO:0036260)	2.43212570
87	branched-chain amino acid metabolic process (GO:0009081)	2.41899025
88	folic acid-containing compound biosynthetic process (GO:0009396)	2.41381472
89	high-density lipoprotein particle remodeling (GO:0034375)	2.40847904
90	termination of RNA polymerase III transcription (GO:0006386)	2.40764548
91	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.40764548
92	hepatocyte apoptotic process (GO:0097284)	2.38911108
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.38391249
94	inner mitochondrial membrane organization (GO:0007007)	2.37482474
95	regulation of RIG-I signaling pathway (GO:0039535)	2.37426232
96	response to pheromone (GO:0019236)	2.37179472
97	NIK/NF-kappaB signaling (GO:0038061)	2.35883301
98	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.35205255
99	positive regulation of macrophage differentiation (GO:0045651)	2.35116235
100	regulation of ligase activity (GO:0051340)	2.34946499

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.60477327
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.39104534
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.35810530
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.19869605
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75641692
6	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.74321281
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.72414269
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.69794681
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.61236086
10	FOXP3_21729870_ChIP-Seq_TREG_Human	2.58771139
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.52775879
12	HOXB4_20404135_ChIP-ChIP_EML_Mouse	2.41880644
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.40567251
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.38638233
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.38026089
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.37191247
17	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.34953500
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24774090
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.20478671
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.10273768
21	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.06693078
22	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.98797919
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.94584040
24	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.88971717
25	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.88471556
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.87964426
27	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.85976299
28	GABP_19822575_ChIP-Seq_HepG2_Human	1.80245818
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.78943800
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.75479066
31	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.74200179
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69208224
33	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.68786523
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.66931480
35	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.66815141
36	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65481044
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.64419986
38	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.63151768
39	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.60732739
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59975555
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.58771963
42	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.57371913
43	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.57273541
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57240653
45	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.50425859
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.47401692
47	MYB_26560356_Chip-Seq_TH2_Human	1.47350798
48	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.47313680
49	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46493081
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44793817
51	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.43205968
52	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.41558268
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.40581259
54	ZNF274_21170338_ChIP-Seq_K562_Hela	1.39121552
55	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37485278
56	TFEB_21752829_ChIP-Seq_HELA_Human	1.32945982
57	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.31671823
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31258086
59	MYB_26560356_Chip-Seq_TH1_Human	1.31086235
60	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.30570281
61	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28398899
62	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.28029509
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27279531
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27142932
65	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.26370513
66	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.22705587
67	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.21481668
68	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.18976680
69	SPI1_23547873_ChIP-Seq_NB4_Human	1.18130373
70	GATA3_26560356_Chip-Seq_TH2_Human	1.17959608
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.15876622
72	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.15330034
73	CIITA_25753668_ChIP-Seq_RAJI_Human	1.15000101
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11600854
75	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.07337069
76	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06667836
77	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.05961819
78	VDR_22108803_ChIP-Seq_LS180_Human	1.05060988
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04684476
80	GATA1_22025678_ChIP-Seq_K562_Human	1.02039538
81	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.01666011
82	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01269122
83	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.00135589
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97027573
85	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.96813131
86	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.93823026
87	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.93699591
88	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92370710
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91418693
90	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.89332812
91	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.88573012
92	ELF5_23300383_ChIP-Seq_T47D_Human	0.88273120
93	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.87412317
94	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.87199367
95	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.87072028
96	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.86701760
97	GATA3_26560356_Chip-Seq_TH1_Human	0.86444921
98	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.83414309
99	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.82918294
100	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.82000921

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.42894980
2	MP0003950_abnormal_plasma_membrane	3.41945848
3	MP0008058_abnormal_DNA_repair	3.10867900
4	MP0005464_abnormal_platelet_physiology	3.01841708
5	MP0005451_abnormal_body_composition	2.86833364
6	MP0003786_premature_aging	2.70766523
7	MP0001835_abnormal_antigen_presentation	2.69345158
8	MP0009840_abnormal_foam_cell	2.61152145
9	MP0005671_abnormal_response_to	2.58254939
10	MP0009333_abnormal_splenocyte_physiolog	2.49634646
11	MP0005075_abnormal_melanosome_morpholog	2.40047696
12	MP0002877_abnormal_melanocyte_morpholog	2.22369152
13	MP0003111_abnormal_nucleus_morphology	2.15425541
14	MP0010094_abnormal_chromosome_stability	2.12345755
15	MP0003763_abnormal_thymus_physiology	2.12128047
16	MP0009785_altered_susceptibility_to	2.08628870
17	MP0000015_abnormal_ear_pigmentation	2.01485327
18	MP0002396_abnormal_hematopoietic_system	1.98942294
19	MP0008007_abnormal_cellular_replicative	1.89108711
20	MP0002102_abnormal_ear_morphology	1.84829522
21	MP0005645_abnormal_hypothalamus_physiol	1.79986453
22	MP0003718_maternal_effect	1.73836201
23	MP0005000_abnormal_immune_tolerance	1.69393037
24	MP0004147_increased_porphyrin_level	1.68658208
25	MP0006036_abnormal_mitochondrial_physio	1.66416152
26	MP0006054_spinal_hemorrhage	1.64829105
27	MP0009697_abnormal_copulation	1.62416987
28	MP0004957_abnormal_blastocyst_morpholog	1.57264211
29	MP0002398_abnormal_bone_marrow	1.51319695
30	MP0001661_extended_life_span	1.50795685
31	MP0005408_hypopigmentation	1.50713457
32	MP0002006_tumorigenesis	1.44262891
33	MP0003077_abnormal_cell_cycle	1.43045863
34	MP0008995_early_reproductive_senescence	1.41206932
35	MP0002148_abnormal_hypersensitivity_rea	1.38816119
36	MP0000703_abnormal_thymus_morphology	1.36121871
37	MP0000685_abnormal_immune_system	1.36083000
38	MP0000358_abnormal_cell_content/	1.33922359
39	MP0000689_abnormal_spleen_morphology	1.30970092
40	MP0008872_abnormal_physiological_respon	1.30656087
41	MP0002166_altered_tumor_susceptibility	1.30384596
42	MP0002722_abnormal_immune_system	1.28553939
43	MP0003283_abnormal_digestive_organ	1.28390630
44	MP0002420_abnormal_adaptive_immunity	1.23124237
45	MP0001819_abnormal_immune_cell	1.20341684
46	MP0002163_abnormal_gland_morphology	1.18040986
47	MP0002723_abnormal_immune_serum	1.15720095
48	MP0010155_abnormal_intestine_physiology	1.15112503
49	MP0003693_abnormal_embryo_hatching	1.14508711
50	MP0005257_abnormal_intraocular_pressure	1.14083610
51	MP0005410_abnormal_fertilization	1.13636766
52	MP0000716_abnormal_immune_system	1.12400833
53	MP0002019_abnormal_tumor_incidence	1.12342007
54	MP0002429_abnormal_blood_cell	1.12149315
55	MP0004381_abnormal_hair_follicle	1.11788944
56	MP0005174_abnormal_tail_pigmentation	1.11694145
57	MP0010352_gastrointestinal_tract_polyps	1.11683364
58	MP0002234_abnormal_pharynx_morphology	1.11262073
59	MP0001529_abnormal_vocalization	1.10177067
60	MP0005310_abnormal_salivary_gland	1.05286718
61	MP0000013_abnormal_adipose_tissue	1.04841098
62	MP0003448_altered_tumor_morphology	1.03896774
63	MP0008260_abnormal_autophagy	1.03319287
64	MP0005025_abnormal_response_to	1.01615323
65	MP0003866_abnormal_defecation	1.00964937
66	MP0002693_abnormal_pancreas_physiology	0.97984081
67	MP0001800_abnormal_humoral_immune	0.97937403
68	MP0002452_abnormal_antigen_presenting	0.97697911
69	MP0001929_abnormal_gametogenesis	0.97431629
70	MP0001666_abnormal_nutrient_absorption	0.96585134
71	MP0006082_CNS_inflammation	0.93175325
72	MP0001845_abnormal_inflammatory_respons	0.91594786
73	MP0010307_abnormal_tumor_latency	0.90209478
74	MP0000371_diluted_coat_color	0.89570320
75	MP0010329_abnormal_lipoprotein_level	0.87597715
76	MP0005220_abnormal_exocrine_pancreas	0.86695601
77	MP0002736_abnormal_nociception_after	0.86317380
78	MP0008057_abnormal_DNA_replication	0.85645364
79	MP0002876_abnormal_thyroid_physiology	0.84969854
80	MP0005167_abnormal_blood-brain_barrier	0.84816490
81	MP0006035_abnormal_mitochondrial_morpho	0.84034828
82	MP0008873_increased_physiological_sensi	0.83106152
83	MP0001790_abnormal_immune_system	0.82487631
84	MP0005387_immune_system_phenotype	0.82487631
85	MP0001119_abnormal_female_reproductive	0.82211752
86	MP0000313_abnormal_cell_death	0.81237616
87	MP0005253_abnormal_eye_physiology	0.80126128
88	MP0000490_abnormal_crypts_of	0.79506926
89	MP0008469_abnormal_protein_level	0.79471325
90	MP0009763_increased_sensitivity_to	0.78888422
91	MP0003186_abnormal_redox_activity	0.76514115
92	MP0000858_altered_metastatic_potential	0.76183360
93	MP0001764_abnormal_homeostasis	0.76080190
94	MP0001730_embryonic_growth_arrest	0.74441689
95	MP0002405_respiratory_system_inflammati	0.73144069
96	MP0003436_decreased_susceptibility_to	0.72018690
97	MP0008932_abnormal_embryonic_tissue	0.71904534
98	MP0002095_abnormal_skin_pigmentation	0.69009851
99	MP0005379_endocrine/exocrine_gland_phen	0.68697605
100	MP0003943_abnormal_hepatobiliary_system	0.68230517

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Optic neuritis (HP:0100653)	4.99874268
2	Retrobulbar optic neuritis (HP:0100654)	4.99874268
3	Orchitis (HP:0100796)	4.04929050
4	Abnormal pupillary function (HP:0007686)	3.93501701
5	Autoimmune hemolytic anemia (HP:0001890)	3.85454083
6	3-Methylglutaconic aciduria (HP:0003535)	3.80562369
7	Myositis (HP:0100614)	3.48172684
8	Petechiae (HP:0000967)	3.46519897
9	Keratoconjunctivitis sicca (HP:0001097)	3.28069252
10	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.26997529
11	Joint swelling (HP:0001386)	3.25260377
12	Upper limb muscle weakness (HP:0003484)	3.22725564
13	Keratoconjunctivitis (HP:0001096)	3.20018646
14	Abnormality of T cells (HP:0002843)	3.12219351
15	Abnormal gallbladder physiology (HP:0012438)	3.10106333
16	Cholecystitis (HP:0001082)	3.10106333
17	Encephalitis (HP:0002383)	3.05083493
18	Abnormality of T cell physiology (HP:0011840)	2.94039523
19	Abnormality of the anterior horn cell (HP:0006802)	2.92882250
20	Degeneration of anterior horn cells (HP:0002398)	2.92882250
21	Abnormality of T cell number (HP:0011839)	2.88920751
22	Abnormality of the pons (HP:0007361)	2.84719873
23	Cutaneous melanoma (HP:0012056)	2.82831852
24	T lymphocytopenia (HP:0005403)	2.82246549
25	Eosinophilia (HP:0001880)	2.81187374
26	Tetraparesis (HP:0002273)	2.73865003
27	Chronic hepatic failure (HP:0100626)	2.72150515
28	Tongue fasciculations (HP:0001308)	2.68395159
29	Panhypogammaglobulinemia (HP:0003139)	2.65444304
30	Granulocytopenia (HP:0001913)	2.64350721
31	Acute encephalopathy (HP:0006846)	2.61825994
32	Hypoproteinemia (HP:0003075)	2.57405237
33	Prolonged bleeding time (HP:0003010)	2.56597057
34	Increased CSF lactate (HP:0002490)	2.50169598
35	Type I transferrin isoform profile (HP:0003642)	2.48033636
36	Acute necrotizing encephalopathy (HP:0006965)	2.46208323
37	Abnormality of eosinophils (HP:0001879)	2.44458186
38	Arterial thrombosis (HP:0004420)	2.41246831
39	Hyperlipoproteinemia (HP:0010980)	2.40991107
40	Menorrhagia (HP:0000132)	2.40366287
41	IgG deficiency (HP:0004315)	2.37753282
42	Hepatosplenomegaly (HP:0001433)	2.36334355
43	Dyschromatopsia (HP:0007641)	2.33798705
44	Increased serum lactate (HP:0002151)	2.33434205
45	Hypothermia (HP:0002045)	2.27882852
46	Progressive muscle weakness (HP:0003323)	2.27620127
47	Anorexia (HP:0002039)	2.26381375
48	Abnormality of the pancreatic islet cells (HP:0006476)	2.24906549
49	Abnormality of endocrine pancreas physiology (HP:0012093)	2.24906549
50	Chronic diarrhea (HP:0002028)	2.24835670
51	Premature ovarian failure (HP:0008209)	2.24214525
52	Polyneuropathy (HP:0001271)	2.23958887
53	Abnormal mitochondria in muscle tissue (HP:0008316)	2.22377217
54	Pulmonary infiltrates (HP:0002113)	2.20864166
55	Muscle fibrillation (HP:0010546)	2.16592313
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13502289
57	IgA deficiency (HP:0002720)	2.12831316
58	Acute hepatic failure (HP:0006554)	2.10625244
59	Epistaxis (HP:0000421)	2.09102345
60	Abnormality of lateral ventricle (HP:0030047)	2.02802165
61	Generalized aminoaciduria (HP:0002909)	2.02127369
62	Progressive macrocephaly (HP:0004481)	2.00994358
63	Hepatocellular necrosis (HP:0001404)	1.98822200
64	Popliteal pterygium (HP:0009756)	1.96929744
65	Squamous cell carcinoma (HP:0002860)	1.96362254
66	Mitochondrial inheritance (HP:0001427)	1.92848533
67	Nausea (HP:0002018)	1.90023416
68	Increased IgM level (HP:0003496)	1.88426634
69	Increased mean platelet volume (HP:0011877)	1.87217135
70	Fatigue (HP:0012378)	1.87004765
71	Gangrene (HP:0100758)	1.84685254
72	Cerebral hypomyelination (HP:0006808)	1.84566566
73	Hypoplasia of the pons (HP:0012110)	1.81764322
74	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.81627174
75	Severe combined immunodeficiency (HP:0004430)	1.81530434
76	Abnormal platelet volume (HP:0011876)	1.80659695
77	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.79949297
78	Hypoplasia of the fovea (HP:0007750)	1.79949297
79	Late onset (HP:0003584)	1.75100263
80	Autoimmune thrombocytopenia (HP:0001973)	1.75017662
81	Abnormal protein glycosylation (HP:0012346)	1.74479930
82	Abnormal glycosylation (HP:0012345)	1.74479930
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.74479930
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.74479930
85	Glomerulopathy (HP:0100820)	1.73993010
86	Hepatic necrosis (HP:0002605)	1.73661349
87	Horizontal nystagmus (HP:0000666)	1.73036914
88	Progressive external ophthalmoplegia (HP:0000590)	1.72425713
89	Volvulus (HP:0002580)	1.71954311
90	Lactic acidosis (HP:0003128)	1.71573259
91	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.71426845
92	Long clavicles (HP:0000890)	1.70644379
93	Aplastic anemia (HP:0001915)	1.70540627
94	Nonimmune hydrops fetalis (HP:0001790)	1.69370394
95	Optic disc pallor (HP:0000543)	1.68430584
96	Purpura (HP:0000979)	1.68061609
97	CNS hypomyelination (HP:0003429)	1.66717443
98	Disproportionate short-trunk short stature (HP:0003521)	1.66691609
99	Loss of speech (HP:0002371)	1.66086711
100	Easy fatigability (HP:0003388)	1.65136964

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.88407376
2	EIF2AK3	4.64099412
3	EIF2AK1	3.81716752
4	BUB1	3.50128865
5	MAP2K6	2.96592224
6	TRIM28	2.83161813
7	TXK	2.73967769
8	MAP4K2	2.65350745
9	TAOK3	2.48320697
10	TSSK6	2.37168883
11	IRAK3	2.35917682
12	CLK1	2.13975665
13	SRPK1	2.00626926
14	MAP4K1	1.97007626
15	BCKDK	1.77443663
16	ZAK	1.67034590
17	PLK3	1.58427969
18	CDK8	1.39289957
19	BMPR1B	1.38518184
20	MAP3K14	1.38406194
21	KDR	1.36795070
22	NEK1	1.34706175
23	TGFBR2	1.33218715
24	PLK2	1.30881999
25	MKNK2	1.30450053
26	BCR	1.26829946
27	MAP3K12	1.24877748
28	NUAK1	1.22299616
29	ITK	1.22121051
30	STK3	1.18334004
31	STK16	1.17675379
32	WEE1	1.14300709
33	JAK3	1.13927539
34	SIK3	1.13329744
35	TNK2	1.11604907
36	BRSK2	1.09892782
37	TLK1	1.09548242
38	PDK2	1.07894814
39	VRK2	1.05945068
40	FGFR4	1.05627120
41	TESK2	0.97982433
42	GRK1	0.95347802
43	FGFR1	0.93750386
44	EIF2AK2	0.85971773
45	NEK9	0.85420158
46	PBK	0.85398146
47	MUSK	0.83985778
48	LIMK1	0.82611532
49	MYLK	0.81255391
50	TYK2	0.75822527
51	TTK	0.75642846
52	PRKCQ	0.75054692
53	VRK1	0.74483249
54	MAPK11	0.73716128
55	FRK	0.73017386
56	STK4	0.72057053
57	MKNK1	0.71920443
58	ILK	0.71236316
59	FER	0.68827958
60	PRKCI	0.67599267
61	MAPKAPK3	0.66963885
62	PRKCH	0.66178916
63	ATR	0.64750371
64	PNCK	0.64353220
65	CDK7	0.62292133
66	CSF1R	0.61664309
67	PLK1	0.61594204
68	SYK	0.60774376
69	PAK3	0.60166643
70	STK10	0.57200879
71	ALK	0.56326030
72	PIM2	0.55578368
73	WNK4	0.53784892
74	DAPK1	0.53403357
75	BMX	0.51603146
76	JAK1	0.47939099
77	PAK4	0.47504392
78	PAK1	0.44850361
79	CAMKK2	0.44637176
80	NME2	0.43271248
81	BRSK1	0.41353928
82	TGFBR1	0.40747019
83	BTK	0.40520215
84	CSNK1G3	0.38249558
85	ACVR1B	0.38149104
86	PTK2B	0.37214745
87	CHEK1	0.37149785
88	ERBB3	0.36865098
89	CHEK2	0.35462253
90	TEC	0.34859249
91	FLT3	0.34421885
92	TBK1	0.33218040
93	LCK	0.33096284
94	CSNK1A1L	0.31814088
95	ATM	0.31416637
96	FGFR3	0.30802763
97	MARK3	0.30383351
98	CSNK1G1	0.28470977
99	KIT	0.28319356
100	IKBKB	0.28187563

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.28144882
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.81991585
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.81752617
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.77732703
5	Basal transcription factors_Homo sapiens_hsa03022	2.44422962
6	RNA polymerase_Homo sapiens_hsa03020	2.38632508
7	Mismatch repair_Homo sapiens_hsa03430	2.25028509
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23770200
9	Protein export_Homo sapiens_hsa03060	2.22377195
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.18860386
11	Homologous recombination_Homo sapiens_hsa03440	2.11118714
12	Sulfur metabolism_Homo sapiens_hsa00920	2.09892856
13	One carbon pool by folate_Homo sapiens_hsa00670	1.99220617
14	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.89904379
15	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.85733818
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84155418
17	DNA replication_Homo sapiens_hsa03030	1.81631866
18	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.81504898
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.81287722
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.78897468
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.69930537
22	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.66083102
23	Propanoate metabolism_Homo sapiens_hsa00640	1.65904066
24	Fatty acid elongation_Homo sapiens_hsa00062	1.64557870
25	RNA transport_Homo sapiens_hsa03013	1.61681279
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56490331
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.55194591
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.50273455
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.48054975
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47083709
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.42481282
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32045476
33	Base excision repair_Homo sapiens_hsa03410	1.30780372
34	Pentose phosphate pathway_Homo sapiens_hsa00030	1.30514960
35	Measles_Homo sapiens_hsa05162	1.27676708
36	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.21183217
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20554539
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14877069
39	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.14428604
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13461179
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.10499689
42	Carbon metabolism_Homo sapiens_hsa01200	1.04391960
43	Spliceosome_Homo sapiens_hsa03040	1.02819817
44	Cell cycle_Homo sapiens_hsa04110	1.01566637
45	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.98776267
46	Herpes simplex infection_Homo sapiens_hsa05168	0.98090081
47	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.97429404
48	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.96142384
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.93692917
50	RNA degradation_Homo sapiens_hsa03018	0.92171059
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91205706
52	Shigellosis_Homo sapiens_hsa05131	0.88142424
53	Regulation of autophagy_Homo sapiens_hsa04140	0.86538992
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85786461
55	Allograft rejection_Homo sapiens_hsa05330	0.84653950
56	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.84375220
57	Legionellosis_Homo sapiens_hsa05134	0.83411660
58	Purine metabolism_Homo sapiens_hsa00230	0.83358337
59	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.83305534
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.76272718
61	Glutathione metabolism_Homo sapiens_hsa00480	0.75957873
62	Platelet activation_Homo sapiens_hsa04611	0.75838190
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.75179817
64	Butanoate metabolism_Homo sapiens_hsa00650	0.74302028
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.72568093
66	p53 signaling pathway_Homo sapiens_hsa04115	0.72430418
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.71099657
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70487537
69	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.64413093
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.64293657
71	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.61726849
72	African trypanosomiasis_Homo sapiens_hsa05143	0.60450940
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59498708
74	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.58984161
75	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.58809658
76	Apoptosis_Homo sapiens_hsa04210	0.56860379
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55536307
78	Oocyte meiosis_Homo sapiens_hsa04114	0.55264806
79	Metabolic pathways_Homo sapiens_hsa01100	0.53465830
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.52359091
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.51639025
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51098621
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.50964075
84	Graft-versus-host disease_Homo sapiens_hsa05332	0.49578862
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.49416898
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.48373952
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.44479639
88	Parkinsons disease_Homo sapiens_hsa05012	0.42781837
89	Huntingtons disease_Homo sapiens_hsa05016	0.42154289
90	Hepatitis B_Homo sapiens_hsa05161	0.41960688
91	Phototransduction_Homo sapiens_hsa04744	0.41515332
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.39738322
93	Sulfur relay system_Homo sapiens_hsa04122	0.37563986
94	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.35085062
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.30404511
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30199404
97	Chemokine signaling pathway_Homo sapiens_hsa04062	0.29817708
98	Linoleic acid metabolism_Homo sapiens_hsa00591	0.29486812
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29329269
100	Circadian rhythm_Homo sapiens_hsa04710	0.29306836

UBE2F-SCLY

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »