UBE2FP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.60584083
2response to peptidoglycan (GO:0032494)5.38587438
3negative regulation of erythrocyte differentiation (GO:0045647)4.68781928
4regulation of vitamin D biosynthetic process (GO:0060556)4.27480542
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.21779096
6regulation of T-helper 1 cell differentiation (GO:0045625)4.05805409
7response to muramyl dipeptide (GO:0032495)3.81531626
8negative regulation of interleukin-12 production (GO:0032695)3.59672690
9neutrophil activation (GO:0042119)3.55347080
10granulocyte activation (GO:0036230)3.54798153
11lipopolysaccharide-mediated signaling pathway (GO:0031663)3.40270798
12regulation of integrin activation (GO:0033623)3.36800193
13regulation of interleukin-8 biosynthetic process (GO:0045414)3.35134512
14negative regulation of interleukin-8 production (GO:0032717)3.33089937
15natural killer cell activation involved in immune response (GO:0002323)3.29916724
16positive regulation of gamma-delta T cell activation (GO:0046645)3.29081215
17regulation of vitamin metabolic process (GO:0030656)3.27789381
18cellular response to arsenic-containing substance (GO:0071243)3.25367197
19Rap protein signal transduction (GO:0032486)3.21609437
20cellular extravasation (GO:0045123)3.08210726
21positive regulation of B cell differentiation (GO:0045579)2.93353275
22regulation of mast cell degranulation (GO:0043304)2.91460345
23cellular response to thyroid hormone stimulus (GO:0097067)2.91339167
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90876997
25megakaryocyte development (GO:0035855)2.88790875
26regulation of MHC class II biosynthetic process (GO:0045346)2.88551632
27nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.86996593
28thrombin receptor signaling pathway (GO:0070493)2.86055770
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85932123
30histamine secretion (GO:0001821)2.84033072
31positive regulation of macrophage differentiation (GO:0045651)2.79517776
32negative regulation of T-helper cell differentiation (GO:0045623)2.77282484
33negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.77282484
34regulation of mast cell activation involved in immune response (GO:0033006)2.76891521
35germinal center formation (GO:0002467)2.76383051
36cell wall macromolecule catabolic process (GO:0016998)2.75307706
37positive regulation of extracellular matrix organization (GO:1903055)2.70039187
38pinocytosis (GO:0006907)2.69712691
39myeloid cell activation involved in immune response (GO:0002275)2.66660118
40platelet aggregation (GO:0070527)2.65866632
41positive regulation of mast cell activation (GO:0033005)2.65298934
42regulation of platelet activation (GO:0010543)2.64141893
43regulation of heterotypic cell-cell adhesion (GO:0034114)2.64132323
44response to laminar fluid shear stress (GO:0034616)2.63299321
45regulation of interleukin-12 biosynthetic process (GO:0045075)2.61249102
46regulation of mast cell activation (GO:0033003)2.59242510
47cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.58664886
48regulation of T-helper 2 cell differentiation (GO:0045628)2.57452204
49regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.56993367
50regulation of interferon-alpha production (GO:0032647)2.56746217
51regulation of leukocyte degranulation (GO:0043300)2.56174625
52macrophage activation involved in immune response (GO:0002281)2.51465806
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50742242
54regulation of chronic inflammatory response (GO:0002676)2.49939055
55immunoglobulin mediated immune response (GO:0016064)2.49521389
56modulation of growth of symbiont involved in interaction with host (GO:0044144)2.49445744
57regulation of growth of symbiont in host (GO:0044126)2.49445744
58negative regulation of growth of symbiont in host (GO:0044130)2.49445744
59negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.49445744
60leukocyte degranulation (GO:0043299)2.49037070
61negative regulation of dendrite morphogenesis (GO:0050774)2.47554762
62positive regulation of interleukin-6 production (GO:0032755)2.46983197
63positive regulation of chemokine biosynthetic process (GO:0045080)2.46596457
64positive regulation of nitric oxide biosynthetic process (GO:0045429)2.44966015
65glycosphingolipid catabolic process (GO:0046479)2.44213589
66neutrophil mediated immunity (GO:0002446)2.42597004
67poly(A)+ mRNA export from nucleus (GO:0016973)2.42444347
68nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.41659298
69embryonic process involved in female pregnancy (GO:0060136)2.41531151
70positive regulation of cellular amide metabolic process (GO:0034250)2.41452074
71positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.39766779
72regulation of interleukin-12 production (GO:0032655)2.39628600
73negative regulation of nitric oxide biosynthetic process (GO:0045019)2.39549421
74negative regulation of interleukin-6 production (GO:0032715)2.38714191
75regulation of interleukin-6 production (GO:0032675)2.37979537
76macrophage activation (GO:0042116)2.37836393
77regulation of nitric oxide biosynthetic process (GO:0045428)2.37316253
78NIK/NF-kappaB signaling (GO:0038061)2.36986739
79positive regulation of T-helper cell differentiation (GO:0045624)2.36961549
80interleukin-1-mediated signaling pathway (GO:0070498)2.36090231
81I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.35842993
82establishment of endothelial barrier (GO:0061028)2.35279523
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.34960705
84definitive hemopoiesis (GO:0060216)2.34823445
85cellular response to lipopolysaccharide (GO:0071222)2.34266853
86neutrophil chemotaxis (GO:0030593)2.33437570
87regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.33111021
88positive regulation of mast cell degranulation (GO:0043306)2.33085681
89positive regulation of mast cell activation involved in immune response (GO:0033008)2.33085681
90regulation of platelet aggregation (GO:0090330)2.33057121
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.32760405
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.32760405
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.32760405
94modulation by symbiont of host immune response (GO:0052553)2.32760405
95positive regulation by symbiont of host defense response (GO:0052509)2.32760405
96modulation by symbiont of host defense response (GO:0052031)2.32760405
97necroptotic process (GO:0070266)2.31894756
98positive regulation of interferon-beta production (GO:0032728)2.31346556
99positive regulation of interferon-alpha production (GO:0032727)2.30932321
100stress fiber assembly (GO:0043149)2.30765777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.78058198
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.98500017
3MYB_21317192_ChIP-Seq_ERMYB_Mouse3.74072623
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.32203791
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.31561612
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27900035
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16628111
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.11576917
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.11076444
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.06593638
11SMAD_19615063_ChIP-ChIP_OVARY_Human3.03818290
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80072321
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.74750785
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.65639084
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.59793170
16SCL_19346495_ChIP-Seq_HPC-7_Human2.42735516
17VDR_24763502_ChIP-Seq_THP-1_Human2.29388021
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26828062
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19531824
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16072332
21VDR_24787735_ChIP-Seq_THP-1_Human2.11826821
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01819729
23GATA1_22025678_ChIP-Seq_K562_Human2.01402959
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99824507
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99229707
26SPI1_23547873_ChIP-Seq_NB4_Human1.91605352
27MYB_26560356_Chip-Seq_TH2_Human1.84673665
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.82713723
29GATA1_19941826_ChIP-Seq_K562_Human1.77227450
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74452671
31RUNX_20019798_ChIP-Seq_JUKART_Human1.68361126
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.68146372
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65159893
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65159893
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65066135
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64360754
37TCF7_22412390_ChIP-Seq_EML_Mouse1.64168227
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63741473
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62960275
40SPI1_23127762_ChIP-Seq_K562_Human1.61353979
41MYC_22102868_ChIP-Seq_BL_Human1.59790152
42MYB_26560356_Chip-Seq_TH1_Human1.58588905
43PU_27001747_Chip-Seq_BMDM_Mouse1.56605738
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.56348656
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55935543
46GATA2_19941826_ChIP-Seq_K562_Human1.54695836
47VDR_21846776_ChIP-Seq_THP-1_Human1.50908778
48MAF_26560356_Chip-Seq_TH1_Human1.49012707
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47542763
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46528070
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46062832
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40933865
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40455974
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.37972992
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36182857
56TFEB_21752829_ChIP-Seq_HELA_Human1.35365183
57E2F7_22180533_ChIP-Seq_HELA_Human1.35054791
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.35023384
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32376831
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32352819
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30936680
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30031084
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28126222
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28022287
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23541592
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22383902
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21505726
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20516794
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18604748
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17132199
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16805031
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14436416
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14045467
74UTX_26944678_Chip-Seq_JUKART_Human1.13943448
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13620984
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.13546395
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12782019
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11912476
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11360239
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11051898
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10670377
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.10350896
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.10285422
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10116339
85GATA3_27048872_Chip-Seq_THYMUS_Human1.09441740
86NCOR1_26117541_ChIP-Seq_K562_Human1.09319239
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09119275
88CLOCK_20551151_ChIP-Seq_293T_Human1.07940319
89GATA3_26560356_Chip-Seq_TH2_Human1.05446333
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03207851
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.03076755
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.02566374
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02111709
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00858156
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99985949
96KDM2B_26808549_Chip-Seq_DND41_Human0.99635773
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97305413
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88558984
99ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87734699
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86674759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.35312502
2MP0005464_abnormal_platelet_physiology3.27520048
3MP0003436_decreased_susceptibility_to2.92375438
4MP0003724_increased_susceptibility_to2.79537099
5MP0003828_pulmonary_edema2.79131122
6MP0010352_gastrointestinal_tract_polyps2.61614826
7MP0001835_abnormal_antigen_presentation2.60531240
8MP0003656_abnormal_erythrocyte_physiolo2.31238562
9MP0005000_abnormal_immune_tolerance2.31085292
10MP0002148_abnormal_hypersensitivity_rea2.29012847
11MP0005058_abnormal_lysosome_morphology2.27361966
12MP0003300_gastrointestinal_ulcer2.26682857
13MP0004947_skin_inflammation2.21613737
14MP0002419_abnormal_innate_immunity2.14367475
15MP0001853_heart_inflammation2.12214974
16MP0008004_abnormal_stomach_pH2.09466565
17MP0009840_abnormal_foam_cell2.03867609
18MP0009785_altered_susceptibility_to1.96780813
19MP0005397_hematopoietic_system_phenotyp1.93007869
20MP0001545_abnormal_hematopoietic_system1.93007869
21MP0004510_myositis1.90954213
22MP0003172_abnormal_lysosome_physiology1.86855253
23MP0009278_abnormal_bone_marrow1.86435099
24MP0006082_CNS_inflammation1.85641781
25MP0005025_abnormal_response_to1.82347035
26MP0003566_abnormal_cell_adhesion1.82197938
27MP0002452_abnormal_antigen_presenting1.79405921
28MP0001800_abnormal_humoral_immune1.74488473
29MP0002723_abnormal_immune_serum1.71428901
30MP0003950_abnormal_plasma_membrane1.68285223
31MP0009764_decreased_sensitivity_to1.65622831
32MP0010155_abnormal_intestine_physiology1.61988842
33MP0006054_spinal_hemorrhage1.59727731
34MP0001533_abnormal_skeleton_physiology1.58956276
35MP0008057_abnormal_DNA_replication1.55786088
36MP0004808_abnormal_hematopoietic_stem1.55401618
37MP0002420_abnormal_adaptive_immunity1.55131815
38MP0003448_altered_tumor_morphology1.54558371
39MP0001819_abnormal_immune_cell1.54380921
40MP0000465_gastrointestinal_hemorrhage1.54084008
41MP0002009_preneoplasia1.46255364
42MP0000343_altered_response_to1.44942548
43MP0001845_abnormal_inflammatory_respons1.44174078
44MP0001851_eye_inflammation1.43972126
45MP0002398_abnormal_bone_marrow1.41926280
46MP0003191_abnormal_cellular_cholesterol1.36931752
47MP0000685_abnormal_immune_system1.35970321
48MP0003091_abnormal_cell_migration1.35014209
49MP0001790_abnormal_immune_system1.33550558
50MP0005387_immune_system_phenotype1.33550558
51MP0002405_respiratory_system_inflammati1.32365007
52MP0003453_abnormal_keratinocyte_physiol1.28364707
53MP0005671_abnormal_response_to1.25892480
54MP0002166_altered_tumor_susceptibility1.23810555
55MP0003075_altered_response_to1.23273187
56MP0005451_abnormal_body_composition1.22883293
57MP0002998_abnormal_bone_remodeling1.22351384
58MP0000716_abnormal_immune_system1.22111655
59MP0005310_abnormal_salivary_gland1.21416657
60MP0002139_abnormal_hepatobiliary_system1.18717466
61MP0005647_abnormal_sex_gland1.18412181
62MP0002877_abnormal_melanocyte_morpholog1.18176514
63MP0000858_altered_metastatic_potential1.15811518
64MP0000689_abnormal_spleen_morphology1.15284794
65MP0009333_abnormal_splenocyte_physiolog1.13839017
66MP0005164_abnormal_response_to1.11605389
67MP0002429_abnormal_blood_cell1.10835157
68MP0002722_abnormal_immune_system1.10627092
69MP0008260_abnormal_autophagy1.09229657
70MP0009765_abnormal_xenobiotic_induced1.09213093
71MP0008469_abnormal_protein_level1.08953813
72MP0002138_abnormal_hepatobiliary_system1.08239236
73MP0008007_abnormal_cellular_replicative1.06137589
74MP0010234_abnormal_vibrissa_follicle1.04440409
75MP0003763_abnormal_thymus_physiology1.03943345
76MP0005076_abnormal_cell_differentiation1.03371812
77MP0002006_tumorigenesis1.02180764
78MP0009763_increased_sensitivity_to1.00459112
79MP0002332_abnormal_exercise_endurance0.99564770
80MP0005167_abnormal_blood-brain_barrier0.99452969
81MP0004883_abnormal_blood_vessel0.95803542
82MP0002254_reproductive_system_inflammat0.95331681
83MP0005166_decreased_susceptibility_to0.94566186
84MP0003221_abnormal_cardiomyocyte_apopto0.91534886
85MP0008961_abnormal_basal_metabolism0.84786549
86MP0005670_abnormal_white_adipose0.84624174
87MP0000249_abnormal_blood_vessel0.84151502
88MP0001216_abnormal_epidermal_layer0.81767805
89MP0005390_skeleton_phenotype0.81397089
90MP0005023_abnormal_wound_healing0.80176069
91MP0005621_abnormal_cell_physiology0.79987915
92MP0005165_increased_susceptibility_to0.79847182
93MP0002132_abnormal_respiratory_system0.79831586
94MP0010307_abnormal_tumor_latency0.79706371
95MP0003045_fibrosis0.78946379
96MP0003795_abnormal_bone_structure0.74158631
97MP0000703_abnormal_thymus_morphology0.73923408
98MP0001663_abnormal_digestive_system0.73729124
99MP0005083_abnormal_biliary_tract0.73701229
100MP0001191_abnormal_skin_condition0.73522936

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)4.98826720
2Petechiae (HP:0000967)4.74480871
3Abnormal platelet volume (HP:0011876)4.19586860
4Increased mean platelet volume (HP:0011877)4.19571443
5Stomatitis (HP:0010280)4.03457251
6Elevated erythrocyte sedimentation rate (HP:0003565)3.92501421
7Menorrhagia (HP:0000132)3.77285994
8Epistaxis (HP:0000421)3.70343778
9Purpura (HP:0000979)3.66641915
10Abnormality of macrophages (HP:0004311)3.48128127
11Recurrent bacterial skin infections (HP:0005406)3.35324404
12Recurrent abscess formation (HP:0002722)3.31110463
13Autoimmune hemolytic anemia (HP:0001890)3.12831133
14Gingival bleeding (HP:0000225)3.12706931
15Autoimmune thrombocytopenia (HP:0001973)3.08567373
16Impaired platelet aggregation (HP:0003540)3.06267392
17Abnormal platelet function (HP:0011869)3.06267392
18Abnormality of glycolipid metabolism (HP:0010969)2.99926414
19Abnormality of liposaccharide metabolism (HP:0010968)2.99926414
20Abnormality of glycosphingolipid metabolism (HP:0004343)2.99926414
21Recurrent viral infections (HP:0004429)2.99632813
22Amyloidosis (HP:0011034)2.98961271
23Increased cerebral lipofuscin (HP:0011813)2.98850885
24Dysostosis multiplex (HP:0000943)2.95154264
25Spondylolisthesis (HP:0003302)2.86695649
26Optic neuritis (HP:0100653)2.72647483
27Retrobulbar optic neuritis (HP:0100654)2.72647483
28Hematochezia (HP:0002573)2.65359674
29Myositis (HP:0100614)2.64266004
30Abnormality of the vasculature of the conjunctiva (HP:0008054)2.62113202
31Orchitis (HP:0100796)2.61901565
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.61242536
33Abnormality of the prostate (HP:0008775)2.59711502
34Myocardial infarction (HP:0001658)2.57742038
35Vacuolated lymphocytes (HP:0001922)2.55334325
36Abnormality of the heme biosynthetic pathway (HP:0010472)2.51067646
37Hepatosplenomegaly (HP:0001433)2.47986890
38Loss of speech (HP:0002371)2.46609095
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.44308950
40Increased serum ferritin (HP:0003281)2.36403763
41Viral hepatitis (HP:0006562)2.35444250
42Episodic fever (HP:0001954)2.33715476
43Acute myeloid leukemia (HP:0004808)2.32111365
44Conjunctival telangiectasia (HP:0000524)2.31334394
45Eczematoid dermatitis (HP:0000976)2.29817925
46Arterial thrombosis (HP:0004420)2.27766128
47Polycythemia (HP:0001901)2.24999334
48Encephalitis (HP:0002383)2.24316537
49Vasculitis (HP:0002633)2.24216689
50Prostate neoplasm (HP:0100787)2.22627043
51Recurrent fungal infections (HP:0002841)2.22303939
52Recurrent skin infections (HP:0001581)2.21863954
53Tetraparesis (HP:0002273)2.20677787
54Increased IgM level (HP:0003496)2.20457212
55Granulocytopenia (HP:0001913)2.19902024
56Spontaneous hematomas (HP:0007420)2.18943379
57Keratoconjunctivitis sicca (HP:0001097)2.16767310
58Axonal loss (HP:0003447)2.14965927
59Leukocytosis (HP:0001974)2.13244939
60Stomach cancer (HP:0012126)2.13091965
61Abnormality of iron homeostasis (HP:0011031)2.13055943
62Recurrent cutaneous fungal infections (HP:0011370)2.11862950
63Chronic mucocutaneous candidiasis (HP:0002728)2.11862950
64Slow saccadic eye movements (HP:0000514)2.09734948
65Fatigue (HP:0012378)2.09618521
66Follicular hyperkeratosis (HP:0007502)2.07969024
67Poikilocytosis (HP:0004447)2.06970766
68Keratoconjunctivitis (HP:0001096)2.02913957
69Chronic obstructive pulmonary disease (HP:0006510)2.02008933
70Obstructive lung disease (HP:0006536)2.02008933
71Paralysis (HP:0003470)1.97062629
72Abnormality of polysaccharide metabolism (HP:0011012)1.96799846
73Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96799846
74Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96799846
75Eosinophilia (HP:0001880)1.94844432
76Pulmonary infiltrates (HP:0002113)1.93798077
77Alopecia of scalp (HP:0002293)1.93286068
78Panhypogammaglobulinemia (HP:0003139)1.92790996
79Abnormality of B cell number (HP:0010975)1.92148791
80Abnormality of lateral ventricle (HP:0030047)1.92129926
81Erythema (HP:0010783)1.91258283
82Abnormality of transition element cation homeostasis (HP:0011030)1.90486226
83Relative macrocephaly (HP:0004482)1.89691895
84Urinary glycosaminoglycan excretion (HP:0003541)1.89329526
85Mucopolysacchariduria (HP:0008155)1.89329526
86Acanthocytosis (HP:0001927)1.89323477
87Subacute progressive viral hepatitis (HP:0006572)1.89141456
88Nausea (HP:0002018)1.88829554
89Alveolar cell carcinoma (HP:0006519)1.88312284
90Mediastinal lymphadenopathy (HP:0100721)1.87872908
91Lower limb hyperreflexia (HP:0002395)1.84748598
92Anhidrosis (HP:0000970)1.84204915
93Dyschromatopsia (HP:0007641)1.83863463
94B lymphocytopenia (HP:0010976)1.82645781
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79770863
96Abnormality of the common coagulation pathway (HP:0010990)1.79298149
97Ocular albinism (HP:0001107)1.77799728
98Bruising susceptibility (HP:0000978)1.77013990
99Osteomyelitis (HP:0002754)1.76813278
100Distal lower limb amyotrophy (HP:0008944)1.76753950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.60121775
2BMPR23.49668655
3MAP3K143.30315653
4MST43.30140604
5PRPF4B3.29287325
6RIPK43.05927939
7MAP3K32.64923821
8TEC2.62656284
9SIK32.51462778
10MAP2K32.40688562
11TAOK22.25705414
12IKBKB2.22112558
13BTK2.02932961
14GRK71.89775576
15IRAK41.88736552
16MATK1.84687512
17IRAK11.82787852
18IRAK21.82019777
19EIF2AK31.75829608
20ZAP701.70651061
21TBK11.67052713
22EIF2AK11.61793345
23TYK21.50774523
24BRSK21.47653781
25IKBKE1.41073461
26AKT31.33144455
27PIK3CG1.31399173
28DYRK31.28901874
29TAOK11.28159505
30BLK1.26612021
31STK241.25153512
32STK101.17562742
33ITK1.16199118
34SYK1.13784284
35CDK121.11891135
36HCK1.10748645
37MOS1.07420914
38CHUK1.05521887
39STK31.04982074
40FGR1.01887239
41TRPM71.01027958
42BMX1.00783505
43MARK30.97897914
44TNK20.96105096
45NME20.93265408
46TGFBR20.91486531
47EPHA20.91173543
48JAK30.90552183
49MAP3K50.89870375
50TAOK30.89160834
51GRK60.88075150
52CSK0.85444965
53JAK10.85083705
54WEE10.84221291
55MAP3K10.83653945
56MAP4K10.79577877
57KIT0.78602610
58CLK10.78103783
59FES0.76287490
60MKNK20.74028344
61MAPK70.69451806
62CDK60.67937553
63LYN0.67629662
64TXK0.67575806
65ERBB30.64532576
66YES10.61980497
67SGK30.61254602
68STK38L0.60899413
69JAK20.59785344
70GSK3A0.59358235
71NEK90.56556428
72CSF1R0.55601535
73MYLK0.55210303
74NEK60.53840061
75RPS6KA40.50328043
76PIM20.49096966
77CDC42BPA0.48382308
78MAP3K110.44970828
79MAP3K130.43889490
80EIF2AK20.43033161
81PDK20.41998797
82PAK40.40917891
83TRIM280.40707398
84PAK10.40475361
85MAP3K80.39107392
86ABL10.38860528
87BRD40.38293091
88LCK0.38272917
89PDK10.38192034
90MKNK10.37567054
91MTOR0.35980512
92MAP2K10.35699107
93PTK2B0.35560249
94ERN10.35098000
95DDR20.35055962
96TTN0.34751224
97BCR0.32988295
98LATS20.31772963
99SGK20.31642721
100ABL20.31468578

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.39012387
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.30772642
3TNF signaling pathway_Homo sapiens_hsa046682.24389126
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23940942
5Legionellosis_Homo sapiens_hsa051342.16570817
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.15706480
7Other glycan degradation_Homo sapiens_hsa005112.11022609
8B cell receptor signaling pathway_Homo sapiens_hsa046622.02538959
9Leishmaniasis_Homo sapiens_hsa051402.01358628
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.96299646
11Acute myeloid leukemia_Homo sapiens_hsa052211.92468989
12Malaria_Homo sapiens_hsa051441.84840663
13Platelet activation_Homo sapiens_hsa046111.75035718
14Influenza A_Homo sapiens_hsa051641.68437087
15Hepatitis B_Homo sapiens_hsa051611.63351512
16Shigellosis_Homo sapiens_hsa051311.62188302
17Toxoplasmosis_Homo sapiens_hsa051451.59051069
18Tuberculosis_Homo sapiens_hsa051521.57929345
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56804737
20Measles_Homo sapiens_hsa051621.53860213
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52911878
22Pertussis_Homo sapiens_hsa051331.50883384
23Hematopoietic cell lineage_Homo sapiens_hsa046401.47890054
24T cell receptor signaling pathway_Homo sapiens_hsa046601.47283733
25Pancreatic cancer_Homo sapiens_hsa052121.44882363
26Chronic myeloid leukemia_Homo sapiens_hsa052201.41894516
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37048017
28African trypanosomiasis_Homo sapiens_hsa051431.35065168
29Sphingolipid metabolism_Homo sapiens_hsa006001.32411015
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.29695848
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27761847
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.27446665
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27342046
34Herpes simplex infection_Homo sapiens_hsa051681.24502388
35Chemokine signaling pathway_Homo sapiens_hsa040621.23510363
36Rheumatoid arthritis_Homo sapiens_hsa053231.19900309
37Lysosome_Homo sapiens_hsa041421.19009693
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18517115
39Apoptosis_Homo sapiens_hsa042101.18117114
40Hepatitis C_Homo sapiens_hsa051601.16560080
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14606606
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13523479
43Amoebiasis_Homo sapiens_hsa051461.13007173
44Staphylococcus aureus infection_Homo sapiens_hsa051501.11853629
45Bladder cancer_Homo sapiens_hsa052191.10255232
46Asthma_Homo sapiens_hsa053101.08940048
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08754320
48Salmonella infection_Homo sapiens_hsa051321.07814929
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07808465
50Prostate cancer_Homo sapiens_hsa052151.04519529
51Non-small cell lung cancer_Homo sapiens_hsa052231.02210391
52Sphingolipid signaling pathway_Homo sapiens_hsa040711.01942876
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.00511229
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99413827
55Renal cell carcinoma_Homo sapiens_hsa052110.97879926
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.97565744
57Allograft rejection_Homo sapiens_hsa053300.91956560
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91702304
59Endometrial cancer_Homo sapiens_hsa052130.89441161
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87845748
61FoxO signaling pathway_Homo sapiens_hsa040680.86021262
62Viral carcinogenesis_Homo sapiens_hsa052030.84326932
63Graft-versus-host disease_Homo sapiens_hsa053320.83786765
64Circadian rhythm_Homo sapiens_hsa047100.83480367
65Small cell lung cancer_Homo sapiens_hsa052220.78356980
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77383632
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.76756289
68Prolactin signaling pathway_Homo sapiens_hsa049170.76200241
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74775609
70VEGF signaling pathway_Homo sapiens_hsa043700.74271476
71Inositol phosphate metabolism_Homo sapiens_hsa005620.72372202
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.70878800
73Insulin resistance_Homo sapiens_hsa049310.68673178
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68613247
75Phagosome_Homo sapiens_hsa041450.68549027
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68267251
77mTOR signaling pathway_Homo sapiens_hsa041500.68169913
78Epstein-Barr virus infection_Homo sapiens_hsa051690.68122595
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67813921
80HIF-1 signaling pathway_Homo sapiens_hsa040660.65040481
81Colorectal cancer_Homo sapiens_hsa052100.61962861
82Viral myocarditis_Homo sapiens_hsa054160.61720929
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60769028
84Regulation of autophagy_Homo sapiens_hsa041400.59570198
85Autoimmune thyroid disease_Homo sapiens_hsa053200.57607850
86Choline metabolism in cancer_Homo sapiens_hsa052310.57420994
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57054574
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55733791
89Pentose phosphate pathway_Homo sapiens_hsa000300.54485411
90HTLV-I infection_Homo sapiens_hsa051660.52155234
91MicroRNAs in cancer_Homo sapiens_hsa052060.50156419
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.49007141
93Type II diabetes mellitus_Homo sapiens_hsa049300.48123376
94Primary immunodeficiency_Homo sapiens_hsa053400.47134151
95Dorso-ventral axis formation_Homo sapiens_hsa043200.43712519
96Endocytosis_Homo sapiens_hsa041440.43439846
97Complement and coagulation cascades_Homo sapiens_hsa046100.42431630
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41764679
99ErbB signaling pathway_Homo sapiens_hsa040120.41621366
100Proteoglycans in cancer_Homo sapiens_hsa052050.41232472

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