UBE2G1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.40461748
2central nervous system myelination (GO:0022010)6.40461748
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.14004321
4microtubule severing (GO:0051013)5.08017642
5cellular ketone body metabolic process (GO:0046950)4.97804347
6regulation of acyl-CoA biosynthetic process (GO:0050812)4.61073817
7lysine metabolic process (GO:0006553)4.53374274
8lysine catabolic process (GO:0006554)4.53374274
9mitotic sister chromatid cohesion (GO:0007064)4.53095950
10pyrimidine nucleobase catabolic process (GO:0006208)4.50660756
11branched-chain amino acid catabolic process (GO:0009083)4.48146442
12mitotic metaphase plate congression (GO:0007080)4.37417203
13fatty acid elongation (GO:0030497)4.32624257
14DNA double-strand break processing (GO:0000729)4.22498746
15ketone body metabolic process (GO:1902224)4.20292688
16IMP biosynthetic process (GO:0006188)4.19557837
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.17109824
18regulation of cofactor metabolic process (GO:0051193)4.11894895
19regulation of coenzyme metabolic process (GO:0051196)4.11894895
20regulation of sulfur metabolic process (GO:0042762)4.03110495
21ribosome assembly (GO:0042255)4.01023279
22histone H2A ubiquitination (GO:0033522)3.99433119
23protein localization to kinetochore (GO:0034501)3.95086183
24metaphase plate congression (GO:0051310)3.90888068
25negative regulation of neurotransmitter secretion (GO:0046929)3.88209202
26nuclear pore complex assembly (GO:0051292)3.84696187
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.84240579
28spindle checkpoint (GO:0031577)3.83215281
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.82012429
30L-phenylalanine catabolic process (GO:0006559)3.79675199
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.79675199
32histone exchange (GO:0043486)3.79302412
33mitotic spindle checkpoint (GO:0071174)3.76641761
34nuclear pore organization (GO:0006999)3.73700463
35regulation of mitotic spindle checkpoint (GO:1903504)3.72857526
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.72857526
37histone H2A monoubiquitination (GO:0035518)3.72320835
38positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.71450337
39mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.71450337
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69888439
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.69888439
42L-methionine salvage (GO:0071267)3.66917548
43L-methionine biosynthetic process (GO:0071265)3.66917548
44amino acid salvage (GO:0043102)3.66917548
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.64241820
46establishment of mitochondrion localization (GO:0051654)3.63360480
47branched-chain amino acid metabolic process (GO:0009081)3.61779285
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.60364846
49negative regulation of sister chromatid segregation (GO:0033046)3.60364846
50negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.60364846
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.60364846
52negative regulation of mitotic sister chromatid segregation (GO:0033048)3.60364846
53regulation of helicase activity (GO:0051095)3.58911272
54negative regulation of chromosome segregation (GO:0051985)3.57666138
55glycerophospholipid catabolic process (GO:0046475)3.55631580
56base-excision repair, AP site formation (GO:0006285)3.52469575
57regulation of mitotic metaphase/anaphase transition (GO:0030071)3.51455155
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.51455155
59positive regulation of chromosome segregation (GO:0051984)3.51228672
60glyoxylate metabolic process (GO:0046487)3.50772083
61mitotic sister chromatid segregation (GO:0000070)3.47528653
62double-strand break repair via nonhomologous end joining (GO:0006303)3.47302894
63non-recombinational repair (GO:0000726)3.47302894
64viral mRNA export from host cell nucleus (GO:0046784)3.46924040
65aspartate family amino acid catabolic process (GO:0009068)3.45199313
66sister chromatid segregation (GO:0000819)3.43847728
67cullin deneddylation (GO:0010388)3.42196665
68regulation of chromosome segregation (GO:0051983)3.41437501
69regulation of mitotic sister chromatid separation (GO:0010965)3.39452707
70regulation of mitotic sister chromatid segregation (GO:0033047)3.39452707
71regulation of sister chromatid segregation (GO:0033045)3.39452707
72pyrimidine nucleotide catabolic process (GO:0006244)3.39002295
73establishment of chromosome localization (GO:0051303)3.38755109
74protein localization to chromosome, centromeric region (GO:0071459)3.37009552
75DNA replication checkpoint (GO:0000076)3.34634611
76regulation of DNA endoreduplication (GO:0032875)3.33777665
77DNA replication-dependent nucleosome assembly (GO:0006335)3.33379503
78DNA replication-dependent nucleosome organization (GO:0034723)3.33379503
79mitotic spindle assembly checkpoint (GO:0007094)3.32657100
80L-phenylalanine metabolic process (GO:0006558)3.29477647
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.29477647
82myelination (GO:0042552)3.29053142
83spindle assembly checkpoint (GO:0071173)3.27087814
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.26843164
85negative regulation of neurotransmitter transport (GO:0051589)3.26037282
86mitotic nuclear envelope disassembly (GO:0007077)3.25169238
87ensheathment of neurons (GO:0007272)3.22680472
88axon ensheathment (GO:0008366)3.22680472
89aspartate family amino acid metabolic process (GO:0009066)3.22404299
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.22279102
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.22279102
92isotype switching (GO:0045190)3.22279102
93response to X-ray (GO:0010165)3.20209919
94nucleobase catabolic process (GO:0046113)3.20206678
95attachment of spindle microtubules to kinetochore (GO:0008608)3.19842143
96serine family amino acid biosynthetic process (GO:0009070)3.14284313
97DNA strand elongation involved in DNA replication (GO:0006271)3.13648481
98protein K11-linked ubiquitination (GO:0070979)3.11592841
99protein deneddylation (GO:0000338)3.09820768
100proteasome assembly (GO:0043248)3.09803286
101positive regulation of mitotic sister chromatid separation (GO:1901970)3.09477800
102positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09477800
103positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09477800
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08750657
105regulation of triglyceride catabolic process (GO:0010896)3.06600690
106purine nucleobase biosynthetic process (GO:0009113)3.05485416
107bile acid biosynthetic process (GO:0006699)3.05403667
108negative regulation of astrocyte differentiation (GO:0048712)3.04972749
109citrulline biosynthetic process (GO:0019240)3.04234894
110mitotic G2/M transition checkpoint (GO:0044818)3.03994365
111somatic recombination of immunoglobulin gene segments (GO:0016447)3.03726974
112RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03275231
113regulation of centriole replication (GO:0046599)3.03067421
114biotin metabolic process (GO:0006768)3.02468264
115membrane disassembly (GO:0030397)3.01899338
116nuclear envelope disassembly (GO:0051081)3.01899338
117DNA damage induced protein phosphorylation (GO:0006975)3.01734446
118transcription from mitochondrial promoter (GO:0006390)3.01441230
119muscle filament sliding (GO:0030049)3.00857473
120actin-myosin filament sliding (GO:0033275)3.00857473
121DNA catabolic process, exonucleolytic (GO:0000738)2.99591111
122DNA strand elongation (GO:0022616)2.98997863
123regulation of histone H3-K27 methylation (GO:0061085)2.98949949
124negative regulation of DNA recombination (GO:0045910)2.95628534
125magnesium ion transport (GO:0015693)2.95476136
126replication fork processing (GO:0031297)2.94418748
127maturation of 5.8S rRNA (GO:0000460)2.94315532
128L-serine metabolic process (GO:0006563)2.93177208
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92883081
130DNA ligation (GO:0006266)2.92089451
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91359808
132histone H2A acetylation (GO:0043968)2.91356350
133telomere maintenance via telomerase (GO:0007004)2.90646245
134regulation of meiosis I (GO:0060631)2.90075180
135righting reflex (GO:0060013)2.89986903
136DNA damage response, detection of DNA damage (GO:0042769)2.89299604
137piRNA metabolic process (GO:0034587)2.88679335
138establishment of viral latency (GO:0019043)2.88441801
139cholesterol biosynthetic process (GO:0006695)2.88248927
140kinetochore assembly (GO:0051382)2.85217415
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.82479017
142lactate metabolic process (GO:0006089)2.82216076
143deoxyribose phosphate catabolic process (GO:0046386)2.80963081
144negative regulation of mitosis (GO:0045839)2.80432098
145mitochondrion transport along microtubule (GO:0047497)2.80338748
146establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.80338748
147nucleobase biosynthetic process (GO:0046112)2.78862486
148mitotic chromosome condensation (GO:0007076)2.78386349
149metanephric tubule development (GO:0072170)2.78212654
150metanephric nephron tubule development (GO:0072234)2.78212654
151positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77941546
152protein K6-linked ubiquitination (GO:0085020)2.77708320
153telomere maintenance via semi-conservative replication (GO:0032201)2.76422605
154aromatic amino acid family catabolic process (GO:0009074)2.75510305
155cysteine metabolic process (GO:0006534)2.73772414
156CENP-A containing nucleosome assembly (GO:0034080)2.70410146
157deoxyribonucleotide catabolic process (GO:0009264)2.69970518
158alpha-linolenic acid metabolic process (GO:0036109)2.69623880
159establishment of integrated proviral latency (GO:0075713)2.68191795
160inner mitochondrial membrane organization (GO:0007007)2.67807287
161IMP metabolic process (GO:0046040)2.66850629
162S-adenosylmethionine metabolic process (GO:0046500)2.66640325
163resolution of meiotic recombination intermediates (GO:0000712)2.66441792
164isoprenoid biosynthetic process (GO:0008299)2.63773500
165sterol biosynthetic process (GO:0016126)2.60902413
166regulation of female gonad development (GO:2000194)2.60192258
167DNA replication-independent nucleosome assembly (GO:0006336)2.59956713
168DNA replication-independent nucleosome organization (GO:0034724)2.59956713
169chaperone-mediated protein transport (GO:0072321)2.58551905
170polyketide metabolic process (GO:0030638)2.57478386
171doxorubicin metabolic process (GO:0044598)2.57478386
172daunorubicin metabolic process (GO:0044597)2.57478386
173histone ubiquitination (GO:0016574)2.55726601
174kinetochore organization (GO:0051383)2.55298377
175creatine metabolic process (GO:0006600)2.55205219
176purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.51678054
177chromatin remodeling at centromere (GO:0031055)2.51086262
178membrane tubulation (GO:0097320)2.50827013
179negative regulation of epidermal cell differentiation (GO:0045605)2.50036284
180positive regulation of mitochondrial membrane permeability (GO:0035794)2.49279562
181myelination in peripheral nervous system (GO:0022011)2.47802156
182peripheral nervous system axon ensheathment (GO:0032292)2.47802156
183serine family amino acid metabolic process (GO:0009069)2.46678107
184response to muscle activity (GO:0014850)2.43718461
185regulation of exit from mitosis (GO:0007096)2.43581896
186platelet dense granule organization (GO:0060155)2.43164800
187metanephric nephron epithelium development (GO:0072243)2.42606194
188very long-chain fatty acid metabolic process (GO:0000038)2.41914852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.72356803
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.52883854
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.41523023
4E2F7_22180533_ChIP-Seq_HELA_Human3.22954433
5AR_21909140_ChIP-Seq_LNCAP_Human3.03718935
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.01313222
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55409922
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33911026
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.31399584
10FUS_26573619_Chip-Seq_HEK293_Human2.28702925
11TAF15_26573619_Chip-Seq_HEK293_Human2.28230863
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.27271109
13PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.16209999
14MYC_18940864_ChIP-ChIP_HL60_Human2.11066558
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09176562
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07573286
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00729296
18HTT_18923047_ChIP-ChIP_STHdh_Human1.98481321
19IGF1R_20145208_ChIP-Seq_DFB_Human1.98136809
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.94789210
21* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91766826
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90778511
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90217747
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.85939598
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.85938632
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84081761
27* VDR_23849224_ChIP-Seq_CD4+_Human1.84011725
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81178026
29FOXP3_21729870_ChIP-Seq_TREG_Human1.81071839
30EWS_26573619_Chip-Seq_HEK293_Human1.80701336
31SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.79857394
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79708366
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.79403564
34VDR_22108803_ChIP-Seq_LS180_Human1.77438486
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.74384017
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72940319
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71333219
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65937889
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64837547
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63606153
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55861718
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55456933
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.55315276
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.50210108
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49736889
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47747762
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46617244
48DCP1A_22483619_ChIP-Seq_HELA_Human1.45841407
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45496478
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44143719
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42272192
52ZNF274_21170338_ChIP-Seq_K562_Hela1.41021431
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40602596
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38568963
55LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38251280
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37468245
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36710651
58SCL_19346495_ChIP-Seq_HPC-7_Human1.36567645
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.35289655
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34055432
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33649339
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33210734
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.32399543
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30918379
65IRF1_19129219_ChIP-ChIP_H3396_Human1.30001310
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28218200
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27543541
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24937707
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23586129
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23165695
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23165695
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22803361
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22594061
74ER_23166858_ChIP-Seq_MCF-7_Human1.21838471
75SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20578253
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20344116
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19409283
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.19007219
79AR_21572438_ChIP-Seq_LNCaP_Human1.18815935
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18758143
81* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.17805110
82* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17727108
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.17466366
84* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16393155
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.15385648
86RNF2_27304074_Chip-Seq_NSC_Mouse1.14215082
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13369854
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13234583
89TTF2_22483619_ChIP-Seq_HELA_Human1.12551191
90* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08693678
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08584334
92* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07844283
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.07319044
94CDX2_22108803_ChIP-Seq_LS180_Human1.06996332
95* CLOCK_20551151_ChIP-Seq_293T_Human1.06869770
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.06165251
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06150380
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05936916
99GABP_19822575_ChIP-Seq_HepG2_Human1.05464025
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04972514
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.03356928
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03103120
103* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02864453
104* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02858075
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02843087
106GBX2_23144817_ChIP-Seq_PC3_Human1.02293126
107JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01744225
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01676365
109* GATA1_26923725_Chip-Seq_HPCs_Mouse1.00496098
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00205392
111SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99199754
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94778461
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94376501
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94335145
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94208209
116ERG_20517297_ChIP-Seq_VCAP_Human0.93421018
117* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93396951
118* P300_19829295_ChIP-Seq_ESCs_Human0.93290049
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92793032
120OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91009541
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90195637
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.86790636
123NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85729334
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85719452
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.85443872
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84994428
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84659239
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84141193
129GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83703935
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.82976513
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82341553
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82341553
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82341553
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81832066
135ELK1_19687146_ChIP-ChIP_HELA_Human0.81565377
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81147933
137* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81104258
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.80775061
139REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80703943
140* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80398361
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79186483
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.78845235
143* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.78427824
144KDM5A_27292631_Chip-Seq_BREAST_Human0.76966719
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75067463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.23776975
2MP0008057_abnormal_DNA_replication4.01652865
3MP0003646_muscle_fatigue3.75591752
4MP0008058_abnormal_DNA_repair3.68540929
5MP0003693_abnormal_embryo_hatching3.54139624
6MP0003806_abnormal_nucleotide_metabolis3.46046795
7MP0005360_urolithiasis3.37498055
8MP0004145_abnormal_muscle_electrophysio3.31000214
9MP0003941_abnormal_skin_development3.25117745
10MP0003111_abnormal_nucleus_morphology3.20758483
11MP0008877_abnormal_DNA_methylation3.17146983
12MP0003718_maternal_effect2.96051450
13MP0005365_abnormal_bile_salt2.82145665
14MP0005085_abnormal_gallbladder_physiolo2.68776110
15MP0005451_abnormal_body_composition2.64227686
16MP0008007_abnormal_cellular_replicative2.38573544
17MP0008875_abnormal_xenobiotic_pharmacok2.33386056
18MP0005423_abnormal_somatic_nervous2.31871302
19MP0003890_abnormal_embryonic-extraembry2.19784123
20MP0004270_analgesia2.01873288
21MP0004134_abnormal_chest_morphology1.98853779
22MP0003221_abnormal_cardiomyocyte_apopto1.96915753
23MP0004036_abnormal_muscle_relaxation1.95370601
24MP0001485_abnormal_pinna_reflex1.94438897
25MP0000566_synostosis1.90287000
26MP0010030_abnormal_orbit_morphology1.89850179
27MP0010352_gastrointestinal_tract_polyps1.87274347
28MP0003937_abnormal_limbs/digits/tail_de1.81845861
29MP0002249_abnormal_larynx_morphology1.77235302
30MP0000372_irregular_coat_pigmentation1.74465754
31MP0009672_abnormal_birth_weight1.71939389
32MP0004215_abnormal_myocardial_fiber1.69686820
33MP0004885_abnormal_endolymph1.68663373
34MP0000465_gastrointestinal_hemorrhage1.68065633
35MP0003252_abnormal_bile_duct1.66640721
36MP0002254_reproductive_system_inflammat1.64400202
37MP0010094_abnormal_chromosome_stability1.61261920
38MP0000733_abnormal_muscle_development1.59509261
39MP0006035_abnormal_mitochondrial_morpho1.55793906
40MP0000920_abnormal_myelination1.51437462
41MP0002106_abnormal_muscle_physiology1.51355238
42MP0005646_abnormal_pituitary_gland1.50793994
43MP0001293_anophthalmia1.48017767
44MP0001529_abnormal_vocalization1.47744753
45MP0000049_abnormal_middle_ear1.46893421
46MP0003938_abnormal_ear_development1.46067507
47MP0009697_abnormal_copulation1.43117906
48MP0000350_abnormal_cell_proliferation1.42412217
49MP0010234_abnormal_vibrissa_follicle1.39679165
50MP0004957_abnormal_blastocyst_morpholog1.39396592
51MP0003943_abnormal_hepatobiliary_system1.38731626
52MP0003567_abnormal_fetal_cardiomyocyte1.38131161
53MP0005620_abnormal_muscle_contractility1.38094139
54MP0001905_abnormal_dopamine_level1.37103535
55MP0006292_abnormal_olfactory_placode1.36913133
56MP0001672_abnormal_embryogenesis/_devel1.36390955
57MP0005380_embryogenesis_phenotype1.36390955
58MP0003786_premature_aging1.35704309
59MP0003195_calcinosis1.35629108
60MP0000747_muscle_weakness1.33806694
61MP0003868_abnormal_feces_composition1.33209800
62MP0003656_abnormal_erythrocyte_physiolo1.31797826
63MP0008789_abnormal_olfactory_epithelium1.31708029
64MP0003011_delayed_dark_adaptation1.31357775
65MP0003950_abnormal_plasma_membrane1.30710827
66MP0005369_muscle_phenotype1.29646234
67MP0003880_abnormal_central_pattern1.28932488
68MP0004197_abnormal_fetal_growth/weight/1.27084051
69MP0008932_abnormal_embryonic_tissue1.25401568
70MP0000579_abnormal_nail_morphology1.24008697
71MP0005187_abnormal_penis_morphology1.23833115
72MP0004147_increased_porphyrin_level1.23783481
73MP0006036_abnormal_mitochondrial_physio1.23758494
74MP0009703_decreased_birth_body1.23681951
75MP0001666_abnormal_nutrient_absorption1.23470917
76MP0002837_dystrophic_cardiac_calcinosis1.18801097
77MP0001730_embryonic_growth_arrest1.17343423
78MP0003984_embryonic_growth_retardation1.16128871
79MP0002088_abnormal_embryonic_growth/wei1.15135920
80MP0002009_preneoplasia1.13537985
81MP0001188_hyperpigmentation1.12958411
82MP0005408_hypopigmentation1.12420474
83MP0000749_muscle_degeneration1.11336181
84MP0010307_abnormal_tumor_latency1.11018456
85MP0004142_abnormal_muscle_tone1.10936445
86MP0000639_abnormal_adrenal_gland1.10241896
87MP0003699_abnormal_female_reproductive1.08381954
88MP0009250_abnormal_appendicular_skeleto1.07055165
89MP0002080_prenatal_lethality1.06042029
90MP0001849_ear_inflammation1.03283024
91MP0004185_abnormal_adipocyte_glucose1.02857180
92MP0002102_abnormal_ear_morphology1.01767497
93MP0004233_abnormal_muscle_weight0.99703107
94MP0005395_other_phenotype0.98231016
95MP0005330_cardiomyopathy0.96600889
96MP0006072_abnormal_retinal_apoptosis0.96498609
97MP0005367_renal/urinary_system_phenotyp0.96487918
98MP0000516_abnormal_urinary_system0.96487918
99MP0000751_myopathy0.96154231
100MP0004087_abnormal_muscle_fiber0.95504010
101MP0003119_abnormal_digestive_system0.95309115
102MP0003121_genomic_imprinting0.94338637
103MP0001929_abnormal_gametogenesis0.94080260
104MP0000759_abnormal_skeletal_muscle0.93356955
105MP0005084_abnormal_gallbladder_morpholo0.92905637
106MP0001286_abnormal_eye_development0.92721904
107MP0002751_abnormal_autonomic_nervous0.91391654
108MP0002932_abnormal_joint_morphology0.90447823
109MP0002127_abnormal_cardiovascular_syste0.90119148
110MP0004084_abnormal_cardiac_muscle0.89785596
111MP0000631_abnormal_neuroendocrine_gland0.89180968
112MP0006054_spinal_hemorrhage0.87606594
113MP0001119_abnormal_female_reproductive0.85805747
114MP0002396_abnormal_hematopoietic_system0.85599095
115MP0003137_abnormal_impulse_conducting0.85246608
116MP0000313_abnormal_cell_death0.84972382
117MP0003077_abnormal_cell_cycle0.84948822
118MP0002234_abnormal_pharynx_morphology0.84861111
119MP0008260_abnormal_autophagy0.84572964
120MP0001984_abnormal_olfaction0.82624166
121MP0005499_abnormal_olfactory_system0.82026688
122MP0005394_taste/olfaction_phenotype0.82026688
123MP0002282_abnormal_trachea_morphology0.81008101
124MP0002269_muscular_atrophy0.80924523
125MP0002210_abnormal_sex_determination0.80841163
126MP0000358_abnormal_cell_content/0.80080161
127MP0002163_abnormal_gland_morphology0.79806691
128MP0000653_abnormal_sex_gland0.79639258
129MP0002796_impaired_skin_barrier0.78800253
130MP0000613_abnormal_salivary_gland0.78017443
131MP0003755_abnormal_palate_morphology0.77858592
132MP0005584_abnormal_enzyme/coenzyme_acti0.77797073
133MP0002972_abnormal_cardiac_muscle0.77574913
134MP0001697_abnormal_embryo_size0.77444188
135MP0002086_abnormal_extraembryonic_tissu0.77025669
136MP0005332_abnormal_amino_acid0.76936243
137MP0001661_extended_life_span0.76700789
138MP0002085_abnormal_embryonic_tissue0.76331164
139MP0001346_abnormal_lacrimal_gland0.76309935
140MP0010678_abnormal_skin_adnexa0.75217806
141MP0005248_abnormal_Harderian_gland0.74470880
142MP0003186_abnormal_redox_activity0.74231368
143MP0005075_abnormal_melanosome_morpholog0.73096933
144MP0001177_atelectasis0.72772267
145MP0002084_abnormal_developmental_patter0.72644692
146MP0004484_altered_response_of0.69437047
147MP0001145_abnormal_male_reproductive0.69319794
148MP0002233_abnormal_nose_morphology0.69260866
149MP0009840_abnormal_foam_cell0.67549865
150MP0000383_abnormal_hair_follicle0.67269043
151MP0004742_abnormal_vestibular_system0.67068867
152MP0003787_abnormal_imprinting0.66710997
153MP0010329_abnormal_lipoprotein_level0.66092414
154MP0003935_abnormal_craniofacial_develop0.66034803
155MP0001544_abnormal_cardiovascular_syste0.65894983
156MP0009053_abnormal_anal_canal0.65667192
157MP0002938_white_spotting0.64681790
158MP0003329_amyloid_beta_deposits0.64635203
159MP0010630_abnormal_cardiac_muscle0.64143012

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.84703221
2Muscle fiber inclusion bodies (HP:0100299)3.96225664
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.96012242
4Nemaline bodies (HP:0003798)3.83283075
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.82453776
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.71487280
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.71487280
8Spastic paraparesis (HP:0002313)3.62411244
9Abnormality of the labia minora (HP:0012880)3.52519121
10Chromsome breakage (HP:0040012)3.46587483
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44936133
12Parakeratosis (HP:0001036)3.22730834
13Colon cancer (HP:0003003)3.18870152
14Hypobetalipoproteinemia (HP:0003563)3.18288406
15Abnormality of alanine metabolism (HP:0010916)3.12632355
16Hyperalaninemia (HP:0003348)3.12632355
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.12632355
18Increased serum pyruvate (HP:0003542)3.08523627
19Abnormality of glycolysis (HP:0004366)3.08523627
20Nephroblastoma (Wilms tumor) (HP:0002667)3.02976790
21Pheochromocytoma (HP:0002666)3.02395457
22CNS hypomyelination (HP:0003429)3.01409217
23Abnormality of methionine metabolism (HP:0010901)2.91630322
24Deep venous thrombosis (HP:0002625)2.90785571
25Calf muscle hypertrophy (HP:0008981)2.89937961
26Abnormality of chromosome stability (HP:0003220)2.87419454
27Abnormality of the corticospinal tract (HP:0002492)2.87136943
28Embryonal renal neoplasm (HP:0011794)2.86464860
29Type 1 muscle fiber predominance (HP:0003803)2.82660647
30Ependymoma (HP:0002888)2.76768903
31Anterior segment dysgenesis (HP:0007700)2.76413974
32Nonprogressive disorder (HP:0003680)2.71306629
33Hyperammonemia (HP:0001987)2.70413752
34Meckel diverticulum (HP:0002245)2.70033116
35Exercise-induced myalgia (HP:0003738)2.68248285
36Exercise-induced muscle cramps (HP:0003710)2.66224005
37Abnormality of the left ventricular outflow tract (HP:0011103)2.63276702
38Subaortic stenosis (HP:0001682)2.63276702
39Absent phalangeal crease (HP:0006109)2.59523572
40Retinal dysplasia (HP:0007973)2.59162727
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58706987
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.57846650
43Rhabdomyosarcoma (HP:0002859)2.57747393
44Ketosis (HP:0001946)2.56335279
45Abnormality of the ileum (HP:0001549)2.55888477
46Delayed myelination (HP:0012448)2.55190553
47Abnormality of the preputium (HP:0100587)2.53571284
48Calcaneovalgus deformity (HP:0001848)2.52181311
49Volvulus (HP:0002580)2.51988531
50Hyperglycinemia (HP:0002154)2.51854321
51Neuroendocrine neoplasm (HP:0100634)2.50715028
52Muscle hypertrophy of the lower extremities (HP:0008968)2.50073488
53Morphological abnormality of the inner ear (HP:0011390)2.49423158
54Abnormality of serum amino acid levels (HP:0003112)2.48617633
55Paraparesis (HP:0002385)2.48264461
56Mutism (HP:0002300)2.45718171
57Prolonged partial thromboplastin time (HP:0003645)2.45315606
58Neoplasm of the adrenal gland (HP:0100631)2.42467806
59Hypolipoproteinemia (HP:0010981)2.42163133
60Small intestinal stenosis (HP:0012848)2.40990717
61Duodenal stenosis (HP:0100867)2.40990717
62Cerebral hypomyelination (HP:0006808)2.40818706
63Steatorrhea (HP:0002570)2.35072185
64Upper motor neuron abnormality (HP:0002127)2.31650949
65Intestinal atresia (HP:0011100)2.31099945
66Increased intramyocellular lipid droplets (HP:0012240)2.30720035
67Fat malabsorption (HP:0002630)2.30456125
68Abnormality of the calf musculature (HP:0001430)2.29773149
69Pancreatic islet-cell hyperplasia (HP:0004510)2.29209516
70Areflexia of lower limbs (HP:0002522)2.27118034
71Abnormality of the duodenum (HP:0002246)2.26146433
72Round ear (HP:0100830)2.26016216
73Rhabdomyolysis (HP:0003201)2.25245725
74Adrenal hypoplasia (HP:0000835)2.23757988
75Abnormality of lateral ventricle (HP:0030047)2.23366575
76Delayed CNS myelination (HP:0002188)2.21999003
77Deformed tarsal bones (HP:0008119)2.21899319
78Long clavicles (HP:0000890)2.21835464
79Methylmalonic acidemia (HP:0002912)2.21318637
80Abnormality of glycine metabolism (HP:0010895)2.20933758
81Abnormality of serine family amino acid metabolism (HP:0010894)2.20933758
82Hypoglycemic coma (HP:0001325)2.20791641
83Hyperglycinuria (HP:0003108)2.20204350
84Biliary tract neoplasm (HP:0100574)2.18382635
85Abnormal finger flexion creases (HP:0006143)2.16883637
86Lethargy (HP:0001254)2.15657047
87Myoglobinuria (HP:0002913)2.14722007
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14222035
89Increased muscle lipid content (HP:0009058)2.14066586
90Neoplasm of the adrenal cortex (HP:0100641)2.13897185
91Breast carcinoma (HP:0003002)2.13168926
92EMG: myopathic abnormalities (HP:0003458)2.10943356
93Metabolic acidosis (HP:0001942)2.10068237
94Diminished motivation (HP:0000745)2.08778145
95Glioma (HP:0009733)2.08129835
96Astrocytoma (HP:0009592)2.07460142
97Abnormality of the astrocytes (HP:0100707)2.07460142
98Type II lissencephaly (HP:0007260)2.07267071
99Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06058383
100Neoplasm of the colon (HP:0100273)2.04188394
101Tetraplegia (HP:0002445)2.04072331
102Distal arthrogryposis (HP:0005684)2.03614394
103Muscle fiber splitting (HP:0003555)2.02549060
104Hypoplasia of the uterus (HP:0000013)2.02437178
105Type 2 muscle fiber atrophy (HP:0003554)2.00777247
106Hypoalphalipoproteinemia (HP:0003233)2.00454397
107Facial hemangioma (HP:0000329)1.99760365
108Abnormal lung lobation (HP:0002101)1.98269305
109Reduced antithrombin III activity (HP:0001976)1.97156731
110Sloping forehead (HP:0000340)1.96910318
111Confusion (HP:0001289)1.96005906
112Neck muscle weakness (HP:0000467)1.95752504
113Leukodystrophy (HP:0002415)1.94259922
114Capillary hemangiomas (HP:0005306)1.93907968
115Multiple enchondromatosis (HP:0005701)1.92582029
116Stenosis of the external auditory canal (HP:0000402)1.92176616
117Disinhibition (HP:0000734)1.91959434
118Shoulder girdle muscle weakness (HP:0003547)1.91287716
119Choreoathetosis (HP:0001266)1.90383266
120Depressed nasal tip (HP:0000437)1.90051639
121Hyperbilirubinemia (HP:0002904)1.88375873
122Birth length less than 3rd percentile (HP:0003561)1.87766953
123Myopathic facies (HP:0002058)1.86871951
124Ovarian neoplasm (HP:0100615)1.85993849
125Abnormality of the musculature of the pelvis (HP:0001469)1.85558670
126Abnormality of the hip-girdle musculature (HP:0001445)1.85558670
127Carpal bone hypoplasia (HP:0001498)1.84255407
128Medulloblastoma (HP:0002885)1.83370918
129Gonadotropin excess (HP:0000837)1.78883871
130Muscle fiber atrophy (HP:0100295)1.78544738
131Type I transferrin isoform profile (HP:0003642)1.77428959
132Embryonal neoplasm (HP:0002898)1.76669023
133Hyperlipoproteinemia (HP:0010980)1.75725257
134Neoplasm of the small intestine (HP:0100833)1.75598670
135Generalized aminoaciduria (HP:0002909)1.75151138
136Abnormality of fatty-acid metabolism (HP:0004359)1.75113147
137Cortical dysplasia (HP:0002539)1.74996342
138Progressive external ophthalmoplegia (HP:0000590)1.74944247
139Microglossia (HP:0000171)1.74888704
140Rimmed vacuoles (HP:0003805)1.74721444
141Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74659153
142Hyperinsulinemic hypoglycemia (HP:0000825)1.74154101
143Short 4th metacarpal (HP:0010044)1.74105629
144Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74105629
145Lipid accumulation in hepatocytes (HP:0006561)1.73022483
146Insidious onset (HP:0003587)1.72819951
147Termporal pattern (HP:0011008)1.72819951
148Clonus (HP:0002169)1.71320208
149Ketoacidosis (HP:0001993)1.70034600
150Epidermoid cyst (HP:0200040)1.69958145
151Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69057866
152Supernumerary spleens (HP:0009799)1.68442126
153Increased hepatocellular lipid droplets (HP:0006565)1.67760334
154Hyporeflexia of lower limbs (HP:0002600)1.67595591
155Prominent metopic ridge (HP:0005487)1.67087138
156Abnormality of the vitreous humor (HP:0004327)1.66821400
157Aqueductal stenosis (HP:0002410)1.66465344
158Horseshoe kidney (HP:0000085)1.66371868
159Spastic paraplegia (HP:0001258)1.66159115
160Purpura (HP:0000979)1.65617192
161Hypoglycemic seizures (HP:0002173)1.64056250
162Myelodysplasia (HP:0002863)1.63653809
163Uterine neoplasm (HP:0010784)1.62699147
164Absent radius (HP:0003974)1.61879088
165Abnormal hair whorl (HP:0010721)1.61594074
166Increased nuchal translucency (HP:0010880)1.60755618
167Abnormality of the metopic suture (HP:0005556)1.60633852
168Ectopic kidney (HP:0000086)1.59403207
169Abnormal protein glycosylation (HP:0012346)1.58591812
170Abnormal glycosylation (HP:0012345)1.58591812
171Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.58591812
172Abnormal protein N-linked glycosylation (HP:0012347)1.58591812
173Proximal amyotrophy (HP:0007126)1.57301465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.71305641
2TRIM283.82544376
3MUSK3.45119054
4EIF2AK13.14165352
5MST43.09436259
6PRPF4B3.06362488
7BCR2.93713415
8TSSK62.93074793
9MAP3K62.89781156
10MAPKAPK32.69209989
11PLK32.53018730
12DYRK22.44197158
13STK392.20284906
14BRSK22.18752638
15ERBB42.03422197
16CCNB11.98320704
17WNK31.91699118
18TAF11.90823814
19ACVR1B1.87336450
20PBK1.85603933
21OXSR11.81020877
22FLT31.79345448
23OBSCN1.77768047
24ZAK1.77698073
25CSNK1G31.75812422
26NME11.73128993
27WEE11.72975704
28NUAK11.68230530
29VRK21.63323066
30CSNK1G11.59891508
31MKNK11.59565296
32CDK81.54024765
33BCKDK1.53953322
34KDR1.50916076
35PHKG21.50345220
36PHKG11.50345220
37CDK191.43914165
38STK161.42217657
39TTK1.40348181
40SRPK11.37358419
41TNIK1.32020155
42PRKD21.30659192
43CSNK1G21.29198850
44EIF2AK31.27887075
45MAP3K101.27796884
46SIK31.22619033
47PINK11.21346923
48PLK21.17171190
49PLK41.16467238
50STK31.16065375
51KSR11.15385000
52MAPKAPK51.14150349
53FGFR21.14095405
54CSNK1A1L1.11793452
55PRKAA21.06657053
56ERBB31.04882576
57BMPR1B0.99260005
58TIE10.97716849
59BRSK10.97119975
60LATS20.96406839
61PASK0.96149133
62ATR0.94148160
63EPHB10.92735125
64UHMK10.91919328
65PIK3CA0.90104394
66MAPK130.89188929
67BRD40.89105107
68DYRK30.85913090
69MELK0.83921482
70KIT0.80338254
71KSR20.79711612
72LIMK10.79521830
73CDC70.79102995
74FRK0.78427333
75NLK0.78091149
76CHEK10.77745660
77NEK10.77682537
78STK240.76893837
79MAP4K20.76820397
80CASK0.76562487
81MAP2K40.76483597
82ATM0.76005693
83MARK10.74307027
84VRK10.72398886
85PNCK0.70591811
86EIF2AK20.66970467
87BUB10.66685494
88MAP2K30.66625518
89PIK3CG0.66211498
90DYRK1B0.64116425
91RAF10.62436258
92PKN10.61717593
93NEK60.60184299
94RPS6KA40.57288520
95PAK60.57207140
96MAP3K40.57038835
97NEK20.56798040
98ILK0.56439377
99TGFBR10.55084234
100NEK90.53486683
101TAOK30.52717353
102MAPK120.52696597
103PKN20.52609503
104STK100.51004384
105HIPK20.50834800
106CLK10.50095613
107STK40.46890947
108PRKG10.45945974
109BRAF0.45885819
110TTN0.45755223
111CHEK20.45423925
112MAP3K80.44767704
113MAP2K70.42489899
114CDK60.42203099
115PDK20.42068373
116YES10.41609550
117MAP3K120.39067149
118RET0.38545589
119CDK10.38086124
120ALK0.37606695
121SGK4940.37574754
122SGK2230.37574754
123GRK10.36605138
124MET0.36446762
125BMPR20.35415021
126PLK10.35176941
127CDK20.32930588
128CSNK2A10.32492232
129EEF2K0.31890640
130CSNK2A20.31346737
131ROCK20.31123785
132CSNK1D0.30969285
133STK38L0.30562366
134CSNK1E0.30444829
135PRKCE0.30107570
136MKNK20.29902592
137PRKDC0.29896007
138CDK70.29676959
139DMPK0.29533062
140MAP2K60.29325795
141AURKB0.28729908
142CDK140.28617699
143FGFR10.28393494
144PRKCI0.27278925
145CDK180.26923958
146PRKCH0.26854038
147MAP3K90.26711840
148PAK30.25962822

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.19438181
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.04372142
3Proteasome_Homo sapiens_hsa030503.18048988
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.96503511
5Propanoate metabolism_Homo sapiens_hsa006402.91372435
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.87145288
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.79205223
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73443563
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69097173
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.56936622
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44930788
12Fatty acid elongation_Homo sapiens_hsa000622.44045971
13Fanconi anemia pathway_Homo sapiens_hsa034602.31951474
14Butanoate metabolism_Homo sapiens_hsa006502.06486660
15DNA replication_Homo sapiens_hsa030301.95218625
16Folate biosynthesis_Homo sapiens_hsa007901.91996286
17Fatty acid degradation_Homo sapiens_hsa000711.88711970
18Pyruvate metabolism_Homo sapiens_hsa006201.84353685
19RNA polymerase_Homo sapiens_hsa030201.81835114
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.79212985
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76138528
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72269222
23Steroid biosynthesis_Homo sapiens_hsa001001.64504901
24RNA degradation_Homo sapiens_hsa030181.63184974
25Fatty acid metabolism_Homo sapiens_hsa012121.59226915
26Arginine biosynthesis_Homo sapiens_hsa002201.55100644
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53892106
28Cell cycle_Homo sapiens_hsa041101.53517873
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48512163
30Peroxisome_Homo sapiens_hsa041461.47327229
31One carbon pool by folate_Homo sapiens_hsa006701.41763968
32Non-homologous end-joining_Homo sapiens_hsa034501.38395766
33Selenocompound metabolism_Homo sapiens_hsa004501.35780647
34Caffeine metabolism_Homo sapiens_hsa002321.30366856
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28216505
36Basal transcription factors_Homo sapiens_hsa030221.22637918
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.15934287
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15250833
39Carbon metabolism_Homo sapiens_hsa012001.13433238
40Biosynthesis of amino acids_Homo sapiens_hsa012301.04299604
41Tryptophan metabolism_Homo sapiens_hsa003801.02722718
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01629285
43beta-Alanine metabolism_Homo sapiens_hsa004101.01348753
44Retinol metabolism_Homo sapiens_hsa008301.01239440
45Chemical carcinogenesis_Homo sapiens_hsa052041.00171660
46Circadian rhythm_Homo sapiens_hsa047101.00054742
47Pyrimidine metabolism_Homo sapiens_hsa002400.99662708
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91863160
49Homologous recombination_Homo sapiens_hsa034400.88155419
50Base excision repair_Homo sapiens_hsa034100.88145576
51Sulfur metabolism_Homo sapiens_hsa009200.86648314
52Arginine and proline metabolism_Homo sapiens_hsa003300.85264218
53Purine metabolism_Homo sapiens_hsa002300.84237643
54Spliceosome_Homo sapiens_hsa030400.82881995
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80054638
56Histidine metabolism_Homo sapiens_hsa003400.79662570
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78173559
58Ovarian steroidogenesis_Homo sapiens_hsa049130.74973096
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.74389591
60Complement and coagulation cascades_Homo sapiens_hsa046100.74367033
61Ether lipid metabolism_Homo sapiens_hsa005650.74151843
62Protein export_Homo sapiens_hsa030600.73604422
63Sulfur relay system_Homo sapiens_hsa041220.71991481
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71927729
65Adherens junction_Homo sapiens_hsa045200.70507431
66Mismatch repair_Homo sapiens_hsa034300.69859579
67RNA transport_Homo sapiens_hsa030130.68339117
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66370676
69Tight junction_Homo sapiens_hsa045300.66331280
70Oocyte meiosis_Homo sapiens_hsa041140.65350936
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63769976
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63303190
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62488170
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62201068
75TGF-beta signaling pathway_Homo sapiens_hsa043500.60682430
76Bile secretion_Homo sapiens_hsa049760.60462706
77Wnt signaling pathway_Homo sapiens_hsa043100.59912638
78Linoleic acid metabolism_Homo sapiens_hsa005910.59503627
79Vitamin B6 metabolism_Homo sapiens_hsa007500.57983371
80Regulation of autophagy_Homo sapiens_hsa041400.56062007
81Glucagon signaling pathway_Homo sapiens_hsa049220.54264557
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54058013
83Huntingtons disease_Homo sapiens_hsa050160.53621153
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52875472
85Hedgehog signaling pathway_Homo sapiens_hsa043400.52706927
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52188885
87Renal cell carcinoma_Homo sapiens_hsa052110.50579264
88Colorectal cancer_Homo sapiens_hsa052100.49966772
89Lysine degradation_Homo sapiens_hsa003100.48127422
90PPAR signaling pathway_Homo sapiens_hsa033200.47802422
91Glutathione metabolism_Homo sapiens_hsa004800.47733372
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47209806
93Axon guidance_Homo sapiens_hsa043600.46229869
94Metabolic pathways_Homo sapiens_hsa011000.46173897
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44623210
96Epstein-Barr virus infection_Homo sapiens_hsa051690.44420170
97* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40981886
98Systemic lupus erythematosus_Homo sapiens_hsa053220.40627301
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40026218
100Starch and sucrose metabolism_Homo sapiens_hsa005000.39418012
101mRNA surveillance pathway_Homo sapiens_hsa030150.38962238
102Oxidative phosphorylation_Homo sapiens_hsa001900.38854119
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37696041
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37007191
105Vitamin digestion and absorption_Homo sapiens_hsa049770.35926501
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35683999
107Phototransduction_Homo sapiens_hsa047440.35650326
108* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34128214
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33379045
110Prostate cancer_Homo sapiens_hsa052150.32178161
111Notch signaling pathway_Homo sapiens_hsa043300.31062110
112Pentose phosphate pathway_Homo sapiens_hsa000300.30009178
113Dorso-ventral axis formation_Homo sapiens_hsa043200.29885271
114Nucleotide excision repair_Homo sapiens_hsa034200.28907445
115Basal cell carcinoma_Homo sapiens_hsa052170.27883475
116Cardiac muscle contraction_Homo sapiens_hsa042600.27546821
117Thyroid cancer_Homo sapiens_hsa052160.26751575
118Viral carcinogenesis_Homo sapiens_hsa052030.22836387
119MicroRNAs in cancer_Homo sapiens_hsa052060.22446659
120Parkinsons disease_Homo sapiens_hsa050120.22234827
121Ras signaling pathway_Homo sapiens_hsa040140.21177109
122Dilated cardiomyopathy_Homo sapiens_hsa054140.20798879
123Insulin signaling pathway_Homo sapiens_hsa049100.20766821
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19994629
125p53 signaling pathway_Homo sapiens_hsa041150.19190012
126Hippo signaling pathway_Homo sapiens_hsa043900.18569631
127Alzheimers disease_Homo sapiens_hsa050100.18458969
128Choline metabolism in cancer_Homo sapiens_hsa052310.16962102
129N-Glycan biosynthesis_Homo sapiens_hsa005100.12306165

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