UBE2G2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)7.52596541
2Golgi transport vesicle coating (GO:0048200)6.40798494
3COPI coating of Golgi vesicle (GO:0048205)6.40798494
4ribosomal small subunit biogenesis (GO:0042274)5.86735286
5nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.17732121
6translational initiation (GO:0006413)4.92859649
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.89504315
8DNA unwinding involved in DNA replication (GO:0006268)4.70286910
9cellular protein complex disassembly (GO:0043624)4.69804470
10ribosomal large subunit biogenesis (GO:0042273)4.65082328
11protein retention in ER lumen (GO:0006621)4.62944800
12viral life cycle (GO:0019058)4.62762826
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.40631948
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.40631948
15negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.39253510
16protein complex disassembly (GO:0043241)4.38036345
17transcription from RNA polymerase I promoter (GO:0006360)4.33175576
18DNA topological change (GO:0006265)4.14556935
19macromolecular complex disassembly (GO:0032984)4.12018109
20actin-myosin filament sliding (GO:0033275)4.10051778
21muscle filament sliding (GO:0030049)4.10051778
22negative regulation of RNA splicing (GO:0033119)4.00335590
23ribonucleoprotein complex biogenesis (GO:0022613)3.93034886
24DNA strand elongation involved in DNA replication (GO:0006271)3.87819837
25DNA replication checkpoint (GO:0000076)3.84573697
26negative regulation of mRNA processing (GO:0050686)3.83875491
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.81189597
28translation (GO:0006412)3.80246715
29mRNA splice site selection (GO:0006376)3.78051298
30nuclear-transcribed mRNA catabolic process (GO:0000956)3.77856186
31purine nucleotide salvage (GO:0032261)3.77028981
32viral mRNA export from host cell nucleus (GO:0046784)3.76932440
33positive regulation of nuclease activity (GO:0032075)3.74654957
34regulation of translational fidelity (GO:0006450)3.69659203
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69348503
36DNA strand elongation (GO:0022616)3.63949736
37mRNA catabolic process (GO:0006402)3.61523201
38antigen processing and presentation of endogenous antigen (GO:0019883)3.60481896
39rRNA processing (GO:0006364)3.56206315
40plasma membrane repair (GO:0001778)3.55662729
41mRNA splicing, via spliceosome (GO:0000398)3.53269914
42RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.53269914
43sarcomere organization (GO:0045214)3.50445221
44nucleobase biosynthetic process (GO:0046112)3.49080896
45RNA splicing, via transesterification reactions (GO:0000375)3.48964739
46oxaloacetate metabolic process (GO:0006107)3.48071575
47regulation of nuclease activity (GO:0032069)3.47738369
48protein targeting to membrane (GO:0006612)3.45437888
49purine nucleobase biosynthetic process (GO:0009113)3.44724746
50ribonucleoprotein complex assembly (GO:0022618)3.41234721
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.41020728
52rRNA metabolic process (GO:0016072)3.40508569
53protein maturation by protein folding (GO:0022417)3.40260054
54RNA catabolic process (GO:0006401)3.40258269
55termination of RNA polymerase II transcription (GO:0006369)3.38576372
564-hydroxyproline metabolic process (GO:0019471)3.38242767
57mitotic sister chromatid segregation (GO:0000070)3.35263898
58tricarboxylic acid cycle (GO:0006099)3.32636693
59activated T cell proliferation (GO:0050798)3.31078440
60tricarboxylic acid metabolic process (GO:0072350)3.30800181
61endoplasmic reticulum unfolded protein response (GO:0030968)3.28092963
62poly(A)+ mRNA export from nucleus (GO:0016973)3.27185902
63negative regulation of mRNA metabolic process (GO:1903312)3.26965382
64sister chromatid segregation (GO:0000819)3.26572526
65ncRNA 3-end processing (GO:0043628)3.25258477
66regulation of mitochondrial translation (GO:0070129)3.24415067
67cellular component biogenesis (GO:0044085)3.23284717
68ribonucleoprotein complex subunit organization (GO:0071826)3.21057434
69COPII vesicle coating (GO:0048208)3.20602688
70ribosomal small subunit assembly (GO:0000028)3.16686972
71antigen processing and presentation via MHC class Ib (GO:0002475)3.15969830
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15847946
73cellular response to unfolded protein (GO:0034620)3.15236259
74nuclear pore complex assembly (GO:0051292)3.13901526
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13745152
76ATP synthesis coupled proton transport (GO:0015986)3.13745152
77termination of RNA polymerase I transcription (GO:0006363)3.12429174
78heterochromatin organization (GO:0070828)3.10354605
79ribosome biogenesis (GO:0042254)3.08054822
80pentose-phosphate shunt (GO:0006098)3.07125306
81valine metabolic process (GO:0006573)3.06978026
82DNA-templated transcription, termination (GO:0006353)3.05923061
83peptidyl-proline hydroxylation (GO:0019511)3.05404021
84alternative mRNA splicing, via spliceosome (GO:0000380)3.05308852
85cellular response to topologically incorrect protein (GO:0035967)3.05153009
86RNA export from nucleus (GO:0006405)3.04742359
87DNA damage response, detection of DNA damage (GO:0042769)3.03315018
88actin-mediated cell contraction (GO:0070252)3.02641786
89telomere maintenance via semi-conservative replication (GO:0032201)3.00553978
90protein hydroxylation (GO:0018126)2.99743414
91negative regulation of cell size (GO:0045792)2.99576156
92DNA replication initiation (GO:0006270)2.99364879
93ER-nucleus signaling pathway (GO:0006984)2.97081144
94mRNA export from nucleus (GO:0006406)2.96318914
952-oxoglutarate metabolic process (GO:0006103)2.95832731
96regulation of translational elongation (GO:0006448)2.91752311
97peptidyl-histidine modification (GO:0018202)2.91570598
98mRNA polyadenylation (GO:0006378)2.90568984
99transcription elongation from RNA polymerase I promoter (GO:0006362)2.90335424
100barbed-end actin filament capping (GO:0051016)2.90276051
101IMP metabolic process (GO:0046040)2.90244729
102folic acid-containing compound biosynthetic process (GO:0009396)2.88736783
103mitotic chromosome condensation (GO:0007076)2.88493487
104spliceosomal snRNP assembly (GO:0000387)2.88276985
105NADH metabolic process (GO:0006734)2.87850939
106regulation of histone H3-K4 methylation (GO:0051569)2.87114047
107galactose catabolic process (GO:0019388)2.86959249
108regulation of skeletal muscle contraction (GO:0014819)2.86628226
109histone H2B ubiquitination (GO:0033523)2.85402576
110chromatin remodeling at centromere (GO:0031055)2.85280213
111purine-containing compound salvage (GO:0043101)2.84762222
112maternal placenta development (GO:0001893)2.83706788
113regulation of DNA damage checkpoint (GO:2000001)2.83634888
114RNA splicing (GO:0008380)2.81826090
115IMP biosynthetic process (GO:0006188)2.81085752
116protein localization to kinetochore (GO:0034501)2.80162225
117mitotic recombination (GO:0006312)2.77070764
118ncRNA processing (GO:0034470)2.76504793
119negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.76106193
120nuclear pore organization (GO:0006999)2.73148859
121transcription initiation from RNA polymerase I promoter (GO:0006361)2.72968846
122mRNA 3-end processing (GO:0031124)2.72700927
123RNA polyadenylation (GO:0043631)2.71359832
124sequestering of metal ion (GO:0051238)2.71128293
125telomere maintenance via recombination (GO:0000722)2.70299048
126spliceosomal complex assembly (GO:0000245)2.68990454
127mitotic nuclear envelope disassembly (GO:0007077)2.68848408
128DNA duplex unwinding (GO:0032508)2.68520172
129SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68364170
130spliceosomal tri-snRNP complex assembly (GO:0000244)2.65382615
131RNA 3-end processing (GO:0031123)2.64761371
132mitochondrial calcium ion transport (GO:0006851)2.61666122
133histone deubiquitination (GO:0016578)2.61556860
134rRNA modification (GO:0000154)2.61324092
135kinetochore organization (GO:0051383)2.61266874
136lysine catabolic process (GO:0006554)2.59310275
137lysine metabolic process (GO:0006553)2.59310275
138protein targeting to ER (GO:0045047)2.57828353
139NADPH regeneration (GO:0006740)2.57318464
140activation of MAPKKK activity (GO:0000185)2.56653558
141response to unfolded protein (GO:0006986)2.55975726
142signal peptide processing (GO:0006465)2.55259179
143cotranslational protein targeting to membrane (GO:0006613)2.52227660
144formation of translation preinitiation complex (GO:0001731)2.51243142
145nucleotide salvage (GO:0043173)2.49752634
146response to topologically incorrect protein (GO:0035966)2.48693910
147translational elongation (GO:0006414)2.46426772
148apoptotic cell clearance (GO:0043277)2.46177206
149establishment of protein localization to endoplasmic reticulum (GO:0072599)2.45734448
150negative regulation of fatty acid transport (GO:2000192)2.45139330
151vesicle coating (GO:0006901)2.44828574
152response to endoplasmic reticulum stress (GO:0034976)2.43402030
153protein localization to endoplasmic reticulum (GO:0070972)2.43216283
154chaperone mediated protein folding requiring cofactor (GO:0051085)2.41403427
155skin morphogenesis (GO:0043589)2.41293529
156nucleobase-containing small molecule interconversion (GO:0015949)2.40111507
157viral transcription (GO:0019083)2.38869620
158T cell apoptotic process (GO:0070231)2.37055150
159regulation of fatty acid oxidation (GO:0046320)2.35689010
160positive regulation of natural killer cell differentiation (GO:0032825)2.33373166
161negative regulation of erythrocyte differentiation (GO:0045647)2.33346241
162heme biosynthetic process (GO:0006783)2.31206641
163AMP metabolic process (GO:0046033)2.28107235
164translational termination (GO:0006415)2.27604277
165ethanol oxidation (GO:0006069)2.26788246
166negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.24570344
167pteridine-containing compound biosynthetic process (GO:0042559)2.23905430
168positive regulation of lamellipodium assembly (GO:0010592)2.23262817
169proline biosynthetic process (GO:0006561)2.22806827
170* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.22696523
171actin filament-based movement (GO:0030048)2.20507974
172platelet aggregation (GO:0070527)2.18496809
173regulation of fatty acid beta-oxidation (GO:0031998)2.18192306
174positive regulation of blood vessel endothelial cell migration (GO:0043536)2.17580583
175regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.15059554
176low-density lipoprotein particle clearance (GO:0034383)2.14691570
177primary alcohol catabolic process (GO:0034310)2.14491421
178positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.14440231
179negative regulation of fibrinolysis (GO:0051918)2.13929024
180DNA deamination (GO:0045006)2.13840981
181positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.13107734
182skeletal muscle contraction (GO:0003009)2.12886316
183oxidative phosphorylation (GO:0006119)2.10225496
184cellular response to arsenic-containing substance (GO:0071243)2.09644047
185glucose catabolic process (GO:0006007)2.08835428
186regulation of translational termination (GO:0006449)2.08426724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75239779
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.57184073
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.43522312
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.90645963
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83252468
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70676564
7THAP11_20581084_ChIP-Seq_MESCs_Mouse2.52446169
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50355866
9MYC_22102868_ChIP-Seq_BL_Human2.49060074
10TTF2_22483619_ChIP-Seq_HELA_Human2.47810182
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39797048
12YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38192593
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37152752
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34556706
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28834321
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.28230705
17FOXP3_21729870_ChIP-Seq_TREG_Human2.25641179
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.20428144
19VDR_21846776_ChIP-Seq_THP-1_Human2.00018992
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95639664
21* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88318488
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.86082875
23KDM5A_27292631_Chip-Seq_BREAST_Human1.86031324
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86010521
25CLOCK_20551151_ChIP-Seq_293T_Human1.85288272
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.84958468
27* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83763347
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82197553
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80297711
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77875423
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.77175778
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75856991
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75816967
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74331335
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74236095
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.72530261
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68914931
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.67701575
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66959007
40* RXR_22158963_ChIP-Seq_LIVER_Mouse1.65911608
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63657202
42* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63537037
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61939661
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61853519
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.61754330
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60584935
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59453391
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53380734
49* GABP_17652178_ChIP-ChIP_JURKAT_Human1.52396644
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52233137
51ELK1_19687146_ChIP-ChIP_HELA_Human1.51522655
52LXR_22292898_ChIP-Seq_THP-1_Human1.49759221
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44740171
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43982493
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43185641
56XRN2_22483619_ChIP-Seq_HELA_Human1.42362189
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.41856213
58MAF_26560356_Chip-Seq_TH1_Human1.41480397
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41478560
60ATF3_27146783_Chip-Seq_COLON_Human1.40865380
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40315329
62ZNF263_19887448_ChIP-Seq_K562_Human1.39744874
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39452955
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39324483
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37530755
66SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.36022784
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35374777
68* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34519901
69UTX_26944678_Chip-Seq_JUKART_Human1.34154706
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33681682
71DCP1A_22483619_ChIP-Seq_HELA_Human1.32392930
72* GABP_19822575_ChIP-Seq_HepG2_Human1.32304800
73* TCF7_22412390_ChIP-Seq_EML_Mouse1.31918665
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30129399
75SCL_19346495_ChIP-Seq_HPC-7_Human1.29834182
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29434404
77* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29095555
78* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28820480
79* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28783245
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28609652
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28494726
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27931228
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27411265
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27334459
85* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26782642
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.26128293
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25220146
88E2F7_22180533_ChIP-Seq_HELA_Human1.24296150
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24291355
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23351803
91VDR_24763502_ChIP-Seq_THP-1_Human1.21968408
92ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21852866
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21461214
94* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20981230
95SPI1_23547873_ChIP-Seq_NB4_Human1.20883418
96RACK7_27058665_Chip-Seq_MCF-7_Human1.20728990
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20677867
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20646555
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.20012924
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19948792
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19762592
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18846362
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17392303
104* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17113841
105TFEB_21752829_ChIP-Seq_HELA_Human1.16954222
106CIITA_25753668_ChIP-Seq_RAJI_Human1.16527929
107NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16515141
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.16325792
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14714968
110KDM2B_26808549_Chip-Seq_DND41_Human1.14322760
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12761210
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12428245
113GATA1_22025678_ChIP-Seq_K562_Human1.12081685
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10631241
115* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10107088
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09927342
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08335953
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07536846
119MYB_26560356_Chip-Seq_TH2_Human1.07200468
120MYC_18940864_ChIP-ChIP_HL60_Human1.07062014
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06946068
122CTCF_21964334_Chip-Seq_Bcells_Human1.06275427
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04685329
124BCL6_27268052_Chip-Seq_Bcells_Human1.04535214
125MAF_26560356_Chip-Seq_TH2_Human1.03971920
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03760325
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02621386
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02396735
129* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01564502
130SRF_21415370_ChIP-Seq_HL-1_Mouse1.01077324
131* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01024090
132* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00797220
133MYB_26560356_Chip-Seq_TH1_Human1.00159979
134* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99871916
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98431652
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98271868
137VDR_23849224_ChIP-Seq_CD4+_Human0.98125886
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97961711
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97715068
140* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97229739
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93644591
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92414186
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90795006
144* NCOR1_26117541_ChIP-Seq_K562_Human0.90268789
145CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84419537
146PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83336344
147IRF1_19129219_ChIP-ChIP_H3396_Human0.83027034
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79719328
149CHD1_26751641_Chip-Seq_LNCaP_Human0.79013218
150TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73241492
151FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71317809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.04153224
2MP0010094_abnormal_chromosome_stability3.85440165
3MP0003111_abnormal_nucleus_morphology3.63666930
4MP0002396_abnormal_hematopoietic_system2.99697858
5MP0000372_irregular_coat_pigmentation2.86681606
6MP0008058_abnormal_DNA_repair2.75592704
7MP0003705_abnormal_hypodermis_morpholog2.72882286
8MP0002837_dystrophic_cardiac_calcinosis2.69699128
9MP0000749_muscle_degeneration2.60296139
10MP0004957_abnormal_blastocyst_morpholog2.58045662
11MP0005075_abnormal_melanosome_morpholog2.56279088
12MP0008007_abnormal_cellular_replicative2.51732820
13MP0008438_abnormal_cutaneous_collagen2.47115158
14MP0003077_abnormal_cell_cycle2.46899691
15MP0005408_hypopigmentation2.46877699
16MP0006035_abnormal_mitochondrial_morpho2.43715518
17MP0008995_early_reproductive_senescence2.28500661
18MP0006292_abnormal_olfactory_placode2.24379241
19MP0006054_spinal_hemorrhage2.22670380
20MP0000751_myopathy2.21515755
21MP0000750_abnormal_muscle_regeneration2.19380474
22MP0008057_abnormal_DNA_replication2.18911588
23MP0003646_muscle_fatigue2.16634703
24MP0003786_premature_aging2.07409662
25MP0000013_abnormal_adipose_tissue1.94072300
26MP0003567_abnormal_fetal_cardiomyocyte1.92023061
27MP0008932_abnormal_embryonic_tissue1.91208875
28MP0004084_abnormal_cardiac_muscle1.91040954
29MP0003566_abnormal_cell_adhesion1.86419121
30MP0000747_muscle_weakness1.86175618
31MP0003136_yellow_coat_color1.78848125
32MP0001529_abnormal_vocalization1.70718929
33MP0009840_abnormal_foam_cell1.70590276
34MP0004087_abnormal_muscle_fiber1.70305385
35MP0002269_muscular_atrophy1.69341430
36MP0005058_abnormal_lysosome_morphology1.65352658
37MP0004036_abnormal_muscle_relaxation1.61939431
38MP0010368_abnormal_lymphatic_system1.61710247
39MP0004381_abnormal_hair_follicle1.61537573
40MP0003279_aneurysm1.61230978
41MP0005171_absent_coat_pigmentation1.58556835
42MP0001730_embryonic_growth_arrest1.57854018
43MP0003436_decreased_susceptibility_to1.57612792
44MP0005330_cardiomyopathy1.57152576
45MP0000759_abnormal_skeletal_muscle1.53731379
46MP0000350_abnormal_cell_proliferation1.52237959
47MP0002877_abnormal_melanocyte_morpholog1.51310141
48MP0000703_abnormal_thymus_morphology1.51040311
49MP0003806_abnormal_nucleotide_metabolis1.50593618
50MP0000858_altered_metastatic_potential1.50342195
51MP0004130_abnormal_muscle_cell1.49039768
52MP0010352_gastrointestinal_tract_polyps1.48076905
53MP0005275_abnormal_skin_tensile1.47549367
54MP0003011_delayed_dark_adaptation1.46158022
55MP0010307_abnormal_tumor_latency1.46149553
56MP0006036_abnormal_mitochondrial_physio1.45283915
57MP0002106_abnormal_muscle_physiology1.44937513
58MP0002095_abnormal_skin_pigmentation1.44496190
59MP0000343_altered_response_to1.41553680
60MP0005023_abnormal_wound_healing1.41336852
61MP0005083_abnormal_biliary_tract1.40371992
62MP0004233_abnormal_muscle_weight1.40251850
63MP0000685_abnormal_immune_system1.38549086
64MP0005365_abnormal_bile_salt1.35563809
65MP0005220_abnormal_exocrine_pancreas1.33361805
66MP0005174_abnormal_tail_pigmentation1.28594723
67MP0004808_abnormal_hematopoietic_stem1.26576445
68MP0003221_abnormal_cardiomyocyte_apopto1.25556391
69MP0000371_diluted_coat_color1.24343968
70MP0010630_abnormal_cardiac_muscle1.23467841
71MP0003656_abnormal_erythrocyte_physiolo1.22748117
72MP0000313_abnormal_cell_death1.21761498
73MP0003300_gastrointestinal_ulcer1.20966082
74MP0009333_abnormal_splenocyte_physiolog1.17154082
75MP0001697_abnormal_embryo_size1.17150356
76MP0002938_white_spotting1.16852983
77MP0001672_abnormal_embryogenesis/_devel1.16483645
78MP0005380_embryogenesis_phenotype1.16483645
79MP0002080_prenatal_lethality1.16156011
80MP0000733_abnormal_muscle_development1.15329555
81MP0001545_abnormal_hematopoietic_system1.14572106
82MP0005397_hematopoietic_system_phenotyp1.14572106
83MP0003984_embryonic_growth_retardation1.13291056
84MP0004145_abnormal_muscle_electrophysio1.12807040
85MP0005319_abnormal_enzyme/_coenzyme1.11895217
86MP0001835_abnormal_antigen_presentation1.11441963
87MP0002088_abnormal_embryonic_growth/wei1.10716272
88MP0005369_muscle_phenotype1.10222703
89MP0003191_abnormal_cellular_cholesterol1.09794076
90MP0009785_altered_susceptibility_to1.09280578
91MP0004947_skin_inflammation1.08769622
92MP0001533_abnormal_skeleton_physiology1.07492592
93MP0001544_abnormal_cardiovascular_syste1.07232894
94MP0005385_cardiovascular_system_phenoty1.07232894
95MP0003303_peritoneal_inflammation1.07192236
96MP0005464_abnormal_platelet_physiology1.07080660
97MP0002933_joint_inflammation1.05469718
98MP0004147_increased_porphyrin_level1.05245890
99MP0001293_anophthalmia1.05200420
100MP0003186_abnormal_redox_activity1.03690936
101MP0004185_abnormal_adipocyte_glucose1.03599687
102MP0003172_abnormal_lysosome_physiology1.02988971
103MP0008260_abnormal_autophagy1.02004805
104MP0002210_abnormal_sex_determination1.01477042
105MP0003937_abnormal_limbs/digits/tail_de1.00096653
106MP0002166_altered_tumor_susceptibility1.00088530
107MP0009672_abnormal_birth_weight0.99723016
108MP0005620_abnormal_muscle_contractility0.99325866
109MP0000609_abnormal_liver_physiology0.99295100
110MP0001661_extended_life_span0.98480619
111MP0002075_abnormal_coat/hair_pigmentati0.97425592
112MP0004510_myositis0.97036993
113MP0000598_abnormal_liver_morphology0.96657215
114MP0003693_abnormal_embryo_hatching0.96118351
115MP0002139_abnormal_hepatobiliary_system0.95042515
116MP0002019_abnormal_tumor_incidence0.94973483
117MP0001186_pigmentation_phenotype0.94908852
118MP0000358_abnormal_cell_content/0.94853334
119MP0003763_abnormal_thymus_physiology0.94505182
120MP0003724_increased_susceptibility_to0.94336249
121MP0001873_stomach_inflammation0.94180214
122MP0002909_abnormal_adrenal_gland0.93184888
123MP0005025_abnormal_response_to0.92673126
124MP0000462_abnormal_digestive_system0.92566473
125MP0001727_abnormal_embryo_implantation0.91514589
126MP0002722_abnormal_immune_system0.91029462
127MP0002693_abnormal_pancreas_physiology0.90835146
128MP0003938_abnormal_ear_development0.90333130
129MP0003283_abnormal_digestive_organ0.90307886
130MP0002085_abnormal_embryonic_tissue0.90222964
131MP0009697_abnormal_copulation0.90187188
132MP0009643_abnormal_urine_homeostasis0.89632474
133MP0001958_emphysema0.88788027
134MP0008961_abnormal_basal_metabolism0.87983518
135MP0001944_abnormal_pancreas_morphology0.87380561
136MP0003315_abnormal_perineum_morphology0.87362510
137MP0005670_abnormal_white_adipose0.86816570
138MP0002972_abnormal_cardiac_muscle0.86793618
139MP0001853_heart_inflammation0.86786285
140MP0002084_abnormal_developmental_patter0.86658010
141MP0001845_abnormal_inflammatory_respons0.86517581
142MP0000428_abnormal_craniofacial_morphol0.85841316
143MP0002419_abnormal_innate_immunity0.85545251
144MP0000003_abnormal_adipose_tissue0.85441695
145MP0000015_abnormal_ear_pigmentation0.85288429
146MP0002108_abnormal_muscle_morphology0.85163721
147MP0008469_abnormal_protein_level0.84580383
148MP0005076_abnormal_cell_differentiation0.83918582
149MP0003828_pulmonary_edema0.82799793
150MP0005375_adipose_tissue_phenotype0.82092559
151MP0002398_abnormal_bone_marrow0.81940417
152MP0001145_abnormal_male_reproductive0.81319052
153MP0009278_abnormal_bone_marrow0.80110826
154MP0002128_abnormal_blood_circulation0.79887799
155MP0000689_abnormal_spleen_morphology0.79834546
156MP0002234_abnormal_pharynx_morphology0.79610271
157MP0004215_abnormal_myocardial_fiber0.79427721
158MP0000767_abnormal_smooth_muscle0.79004569
159MP0001879_abnormal_lymphatic_vessel0.78918027
160MP0000249_abnormal_blood_vessel0.78768568
161MP0002078_abnormal_glucose_homeostasis0.78669272
162MP0001243_abnormal_dermal_layer0.78508755
163MP0005000_abnormal_immune_tolerance0.78262499
164MP0004197_abnormal_fetal_growth/weight/0.77331489
165MP0001324_abnormal_eye_pigmentation0.74291265
166MP0002429_abnormal_blood_cell0.73335099
167MP0002009_preneoplasia0.72989129
168MP0003943_abnormal_hepatobiliary_system0.70410311
169MP0001851_eye_inflammation0.69082806
170MP0000049_abnormal_middle_ear0.68824239
171MP0004142_abnormal_muscle_tone0.68128351
172MP0002086_abnormal_extraembryonic_tissu0.66147541
173MP0000653_abnormal_sex_gland0.65409827

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.19075841
2Abnormality of cells of the erythroid lineage (HP:0012130)4.81837922
3Abnormal number of erythroid precursors (HP:0012131)4.78251646
4Muscle fiber inclusion bodies (HP:0100299)4.38842562
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.30183380
6Microvesicular hepatic steatosis (HP:0001414)4.15984430
7Nemaline bodies (HP:0003798)3.98901361
8Type 1 muscle fiber predominance (HP:0003803)3.96733982
9Macrocytic anemia (HP:0001972)3.87610195
10Protrusio acetabuli (HP:0003179)3.64785643
11Myoglobinuria (HP:0002913)3.48617337
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.45434834
13Distal arthrogryposis (HP:0005684)3.44309766
14Pallor (HP:0000980)3.41842714
1511 pairs of ribs (HP:0000878)3.29703302
16Asymmetric septal hypertrophy (HP:0001670)3.28537063
17Increased connective tissue (HP:0009025)3.25644067
18Myopathic facies (HP:0002058)3.17289559
19Recurrent gram-negative bacterial infections (HP:0005420)3.17273496
20Exercise-induced muscle cramps (HP:0003710)3.16657096
21Mesomelia (HP:0003027)3.13764452
22Ulnar deviation of the wrist (HP:0003049)3.12930737
23Exercise-induced myalgia (HP:0003738)3.11566544
24Hypoglycemic coma (HP:0001325)3.10414107
25Chromsome breakage (HP:0040012)3.04008973
26Rhabdomyolysis (HP:0003201)3.02802083
27Muscle fiber splitting (HP:0003555)2.99308732
28Broad distal phalanx of finger (HP:0009836)2.96464801
29Abnormality of reticulocytes (HP:0004312)2.91344386
30Nasal speech (HP:0001611)2.91277260
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91095312
32Sparse scalp hair (HP:0002209)2.87717763
33Difficulty climbing stairs (HP:0003551)2.84537074
34Acute necrotizing encephalopathy (HP:0006965)2.83433083
35Panhypogammaglobulinemia (HP:0003139)2.77431424
363-Methylglutaconic aciduria (HP:0003535)2.76557431
37Facial cleft (HP:0002006)2.76331637
38Thrombocytosis (HP:0001894)2.73903232
39Abnormality of the intervertebral disk (HP:0005108)2.73628319
40Progressive muscle weakness (HP:0003323)2.72675836
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.71345156
42Abnormal mitochondria in muscle tissue (HP:0008316)2.66721294
43Abnormality of cochlea (HP:0000375)2.66062358
44Periodontitis (HP:0000704)2.65564398
45Abnormality of homocysteine metabolism (HP:0010919)2.64498696
46Homocystinuria (HP:0002156)2.64498696
47Deep philtrum (HP:0002002)2.63077740
48Broad palm (HP:0001169)2.63061750
49Abnormality of fatty-acid metabolism (HP:0004359)2.58737457
50Hyporeflexia of lower limbs (HP:0002600)2.57377633
51EMG: myopathic abnormalities (HP:0003458)2.55361257
52Acute lymphatic leukemia (HP:0006721)2.54933283
53Calcaneovalgus deformity (HP:0001848)2.53104749
54Abnormality of skeletal muscle fiber size (HP:0012084)2.50679298
55Late onset (HP:0003584)2.48466338
56Limb-girdle muscle atrophy (HP:0003797)2.46413548
57Autoimmune hemolytic anemia (HP:0001890)2.46341554
58Abnormal number of incisors (HP:0011064)2.45710704
59Mitochondrial inheritance (HP:0001427)2.40285751
60Round ear (HP:0100830)2.40005752
61Patellar aplasia (HP:0006443)2.38727788
62Hepatocellular necrosis (HP:0001404)2.37008134
63Ventricular tachycardia (HP:0004756)2.36955019
64Abnormality of T cell physiology (HP:0011840)2.35813765
65Deformed tarsal bones (HP:0008119)2.34235338
66Vertebral compression fractures (HP:0002953)2.31143174
67Spinal rigidity (HP:0003306)2.29983095
68Acute encephalopathy (HP:0006846)2.28366276
69Lipoatrophy (HP:0100578)2.26642016
70Increased hepatocellular lipid droplets (HP:0006565)2.26415362
71Aplasia/Hypoplasia of the patella (HP:0006498)2.26200845
72Polycythemia (HP:0001901)2.23337198
73Meckel diverticulum (HP:0002245)2.21947533
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.21591208
75Abnormality of the fingertips (HP:0001211)2.21339739
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.20538710
77Abnormality of the nasal mucosa (HP:0000433)2.19913234
78Myelodysplasia (HP:0002863)2.18570394
79Muscle stiffness (HP:0003552)2.18259319
80Premature rupture of membranes (HP:0001788)2.18002330
81Morphological abnormality of the inner ear (HP:0011390)2.17238926
82Abnormality of the calcaneus (HP:0008364)2.16356996
83Truncus arteriosus (HP:0001660)2.15941817
84Abnormal sex determination (HP:0012244)2.15714467
85Sex reversal (HP:0012245)2.15714467
86Seborrheic dermatitis (HP:0001051)2.15385847
87Muscle fiber atrophy (HP:0100295)2.15016119
88Difficulty running (HP:0009046)2.14820684
89Multiple enchondromatosis (HP:0005701)2.14272157
90Cerebral aneurysm (HP:0004944)2.13896544
91Myotonia (HP:0002486)2.13548725
92Increased variability in muscle fiber diameter (HP:0003557)2.12517585
93Subaortic stenosis (HP:0001682)2.10139338
94Abnormality of the left ventricular outflow tract (HP:0011103)2.10139338
95Hepatic necrosis (HP:0002605)2.09227511
96Progressive macrocephaly (HP:0004481)2.08713082
97Abnormality of the ileum (HP:0001549)2.08564683
98Calf muscle hypertrophy (HP:0008981)2.08014358
99Birth length less than 3rd percentile (HP:0003561)2.07663669
100Malignant hyperthermia (HP:0002047)2.06629789
101Beaking of vertebral bodies (HP:0004568)2.06204723
102Lipid accumulation in hepatocytes (HP:0006561)2.06173802
103Right ventricular cardiomyopathy (HP:0011663)2.05694931
104Increased CSF lactate (HP:0002490)2.02445861
105Aortic aneurysm (HP:0004942)2.01999839
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01416890
107Ketoacidosis (HP:0001993)2.00784256
108Neck muscle weakness (HP:0000467)1.99423645
109B lymphocytopenia (HP:0010976)1.97726768
110Frequent falls (HP:0002359)1.97048403
111Increased serum lactate (HP:0002151)1.96094931
112Sudden death (HP:0001699)1.96030193
113Abnormality of the intrinsic pathway (HP:0010989)1.95766104
114Granulocytopenia (HP:0001913)1.95705721
115Rib fusion (HP:0000902)1.95589100
116Rhizomelia (HP:0008905)1.94562975
117Exercise intolerance (HP:0003546)1.93007364
118Nasal polyposis (HP:0100582)1.92938392
119Mildly elevated creatine phosphokinase (HP:0008180)1.92545598
120Joint stiffness (HP:0001387)1.92422946
121Palpitations (HP:0001962)1.92299788
122Missing ribs (HP:0000921)1.92000169
123Respiratory difficulties (HP:0002880)1.91868060
124Dysostosis multiplex (HP:0000943)1.90278579
125Abnormality of the preputium (HP:0100587)1.90073336
126Abnormality of the labia minora (HP:0012880)1.89965755
127Type 2 muscle fiber atrophy (HP:0003554)1.88790426
128Abnormality of the calf musculature (HP:0001430)1.87233851
129Generalized aminoaciduria (HP:0002909)1.87028995
130Generalized amyotrophy (HP:0003700)1.86936566
131Muscle hypertrophy of the lower extremities (HP:0008968)1.86696338
132Severe combined immunodeficiency (HP:0004430)1.85642032
133Abnormality of chromosome stability (HP:0003220)1.85214349
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84828366
135Dicarboxylic aciduria (HP:0003215)1.84828366
136Dilated cardiomyopathy (HP:0001644)1.84346544
137Peritonitis (HP:0002586)1.84192796
138Insulin resistance (HP:0000855)1.83724716
139Reticulocytosis (HP:0001923)1.83471592
140Increased serum ferritin (HP:0003281)1.82970536
141Colon cancer (HP:0003003)1.82968928
142Abnormality of glycolysis (HP:0004366)1.82815873
143Cerebral edema (HP:0002181)1.82460687
144Chronic bronchitis (HP:0004469)1.81348400
145Abnormality of B cell number (HP:0010975)1.80476860
146Urinary glycosaminoglycan excretion (HP:0003541)1.79886639
147Mucopolysacchariduria (HP:0008155)1.79886639
148Increased intramyocellular lipid droplets (HP:0012240)1.79604562
149Hyperinsulinemic hypoglycemia (HP:0000825)1.79552638
150Abnormal platelet function (HP:0011869)1.79006780
151Impaired platelet aggregation (HP:0003540)1.79006780
152Overlapping toe (HP:0001845)1.78988241
153Impaired proprioception (HP:0010831)1.78886309
154Increased density of long bones (HP:0006392)1.78499860
155Hypoglycemic seizures (HP:0002173)1.78425065
156Cortical visual impairment (HP:0100704)1.77685221
157Testicular atrophy (HP:0000029)1.77454932
158Leukocytosis (HP:0001974)1.77200789
159Ketosis (HP:0001946)1.76954589
160Aplastic anemia (HP:0001915)1.76818742
161Cervical subluxation (HP:0003308)1.76573084
162Facial diplegia (HP:0001349)1.76307927
163Absent phalangeal crease (HP:0006109)1.76241646
164Cholecystitis (HP:0001082)1.76168928
165Abnormal gallbladder physiology (HP:0012438)1.76168928
166IgM deficiency (HP:0002850)1.76125658
167Recurrent abscess formation (HP:0002722)1.75641335
168Squamous cell carcinoma (HP:0002860)1.75041112
169Rhabdomyosarcoma (HP:0002859)1.73989122
170Abnormal cartilage morphology (HP:0002763)1.73196150
171Maternal diabetes (HP:0009800)1.73171054
172Degeneration of anterior horn cells (HP:0002398)1.73101899
173Abnormality of the anterior horn cell (HP:0006802)1.73101899
174Aplasia/Hypoplasia of the uvula (HP:0010293)1.72956226
175Elevated erythrocyte sedimentation rate (HP:0003565)1.72739429
176Abnormality of DNA repair (HP:0003254)1.72651295
177Acute myeloid leukemia (HP:0004808)1.72369906
178Conjunctival hamartoma (HP:0100780)1.71233369
179Areflexia of lower limbs (HP:0002522)1.69328301
180Ragged-red muscle fibers (HP:0003200)1.68309127
181Type I transferrin isoform profile (HP:0003642)1.67924326
182Spondylolisthesis (HP:0003302)1.67128678
183Generalized muscle weakness (HP:0003324)1.67022164
184Duplicated collecting system (HP:0000081)1.66873967
185Abnormality of the common coagulation pathway (HP:0010990)1.66525770
186Gout (HP:0001997)1.65252075
187Thick lower lip vermilion (HP:0000179)1.64987904
188Large for gestational age (HP:0001520)1.64523957
189Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.64479949
190Decreased activity of mitochondrial respiratory chain (HP:0008972)1.64479949
191Cupped ribs (HP:0000887)1.64470682
192Easy fatigability (HP:0003388)1.64455747
193Deep venous thrombosis (HP:0002625)1.63431327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.83920116
2ERN14.59137536
3PBK4.03697882
4FES3.99807007
5TTN3.60015257
6CDC73.53842434
7MAP3K133.28959559
8PKN23.00936992
9MAP2K32.80597796
10ICK2.80350645
11SRPK12.78730684
12BCKDK2.58634043
13VRK22.51175509
14EEF2K2.42773051
15NME22.30565827
16WEE12.11686676
17OBSCN2.05741793
18ZAP701.98508767
19MKNK11.90019253
20FLT31.87263324
21MAP3K31.80028564
22LRRK21.79252536
23KDR1.78775323
24MAPKAPK31.75887260
25TXK1.75388093
26TTK1.70298578
27MAP4K11.69184784
28SMG11.67918663
29ATR1.59504123
30MAP3K111.57458182
31TESK11.56873259
32PIK3CG1.54902718
33CDK121.54627435
34MKNK21.53726139
35NEK11.49131726
36RPS6KA41.49088352
37PIM21.45772406
38TGFBR11.40775699
39TYRO31.38209243
40BRSK21.36922397
41TGFBR21.35142149
42ALK1.32782277
43TBK11.32574080
44TAOK11.32389752
45PASK1.30141483
46MAP3K101.26993497
47NEK91.26225746
48EIF2AK11.23086758
49SCYL21.22978338
50CHEK11.19616744
51TIE11.17236433
52ILK1.15935708
53JAK31.15891286
54TESK21.15281536
55FGFR41.13343770
56STK101.09460114
57PLK41.08169196
58SIK11.07729702
59FER1.06258029
60TYK21.03745674
61PNCK1.02414072
62CHEK21.01565118
63TAOK30.96813292
64TAOK20.96680609
65TSSK60.96453709
66MYLK0.96394402
67PAK40.95335386
68STK40.94377522
69PTK60.93441535
70WNK10.92720269
71MAP3K80.91424603
72NME10.90591620
73ATM0.90192180
74PDGFRA0.87658035
75CLK10.85289377
76DMPK0.83004727
77TAF10.83000094
78BRD40.82767972
79LIMK10.82222876
80PLK30.81704242
81EPHA30.81535878
82BUB10.81094979
83MAP2K60.80978375
84IRAK30.80731481
85MOS0.79912275
86RPS6KB20.78812842
87PDK40.78089022
88PDK30.78089022
89STK160.78014306
90BLK0.77933061
91CSNK1E0.75662398
92EIF2AK20.75162307
93MAP3K50.74944886
94BTK0.74441385
95AURKB0.72530356
96PLK10.71691141
97MAP3K10.71345233
98CDK20.70964368
99EIF2AK30.70185010
100CDK70.68501895
101NUAK10.68362961
102FGFR20.67355548
103KIT0.65541425
104KSR20.63902923
105RIPK10.62214843
106BMPR1B0.61800663
107CDK10.61638977
108PAK20.61503029
109MAP3K70.61075856
110DYRK20.59839818
111JAK10.59389565
112MAPK110.57436574
113MAP2K10.57084531
114BRSK10.56240681
115BRAF0.55893217
116NLK0.55590635
117VRK10.55098065
118CSNK2A20.54823562
119SYK0.54488936
120PRKG20.52158655
121LATS20.50984010
122UHMK10.50040588
123FGFR10.49777340
124TEC0.49662617
125CDK190.49152954
126DAPK30.48818901
127PRKD30.47378556
128MAPK120.45607633
129DYRK30.44972200
130CDK30.44585408
131PTK20.44053494
132DAPK10.43841495
133PRKDC0.43572393
134PHKG20.42897103
135PHKG10.42897103
136CDK40.42552244
137ITK0.42034694
138RPS6KA10.41543149
139MAPKAPK20.41429905
140MARK30.39609441
141TRPM70.39293086
142KSR10.38519122
143MAPK140.38083975
144CSNK2A10.37741503
145RAF10.37549691
146LCK0.37535529
147MAP2K20.36958905
148MTOR0.36255358
149JAK20.35788118
150PRKCH0.35640953
151NEK20.35262478
152MAP3K140.34944166
153CSF1R0.34575919
154TNIK0.33984260
155RPS6KC10.33596534
156CDK80.32938654
157RET0.29827558
158CAMKK20.29502271
159MAPK40.28479823
160ABL20.28293299
161RPS6KA60.28099758
162FGFR30.27880379
163PDK20.27628542

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.37302170
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.01731868
3Spliceosome_Homo sapiens_hsa030403.77442851
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27851168
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.87046322
6Homologous recombination_Homo sapiens_hsa034402.66115577
7RNA transport_Homo sapiens_hsa030132.64707247
8Mismatch repair_Homo sapiens_hsa034302.52067021
9Non-homologous end-joining_Homo sapiens_hsa034502.40942324
10Sulfur relay system_Homo sapiens_hsa041222.25553895
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23580678
12* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.23326525
13Fatty acid degradation_Homo sapiens_hsa000712.07419143
14Carbon metabolism_Homo sapiens_hsa012002.03721508
15Protein export_Homo sapiens_hsa030602.02507128
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.00945944
17RNA degradation_Homo sapiens_hsa030181.98834017
18mRNA surveillance pathway_Homo sapiens_hsa030151.98816080
19Nucleotide excision repair_Homo sapiens_hsa034201.97830596
20Cell cycle_Homo sapiens_hsa041101.68413922
21Selenocompound metabolism_Homo sapiens_hsa004501.67352567
22Parkinsons disease_Homo sapiens_hsa050121.66876980
23Oxidative phosphorylation_Homo sapiens_hsa001901.65785708
24Biosynthesis of amino acids_Homo sapiens_hsa012301.64154407
25Galactose metabolism_Homo sapiens_hsa000521.63032248
26Ribosome_Homo sapiens_hsa030101.60392839
27Legionellosis_Homo sapiens_hsa051341.59569972
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59535493
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59354219
30Purine metabolism_Homo sapiens_hsa002301.57286214
31Fanconi anemia pathway_Homo sapiens_hsa034601.56880462
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56380729
33Proteasome_Homo sapiens_hsa030501.54169235
34Other glycan degradation_Homo sapiens_hsa005111.51632256
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.44912213
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40666554
37Pentose phosphate pathway_Homo sapiens_hsa000301.40594941
38Antigen processing and presentation_Homo sapiens_hsa046121.39322011
39Huntingtons disease_Homo sapiens_hsa050161.33975052
40Primary immunodeficiency_Homo sapiens_hsa053401.33472372
41Basal transcription factors_Homo sapiens_hsa030221.32663435
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32509493
43Non-small cell lung cancer_Homo sapiens_hsa052231.31641399
44Leishmaniasis_Homo sapiens_hsa051401.27387648
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.26729785
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26064526
47Viral myocarditis_Homo sapiens_hsa054161.25633996
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.25117642
49Folate biosynthesis_Homo sapiens_hsa007901.21533017
50N-Glycan biosynthesis_Homo sapiens_hsa005101.21348967
51Pyruvate metabolism_Homo sapiens_hsa006201.19152239
52Propanoate metabolism_Homo sapiens_hsa006401.17468975
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17460620
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13950727
55Starch and sucrose metabolism_Homo sapiens_hsa005001.11759254
56Lysine degradation_Homo sapiens_hsa003101.05879084
57DNA replication_Homo sapiens_hsa030301.03786292
58Insulin resistance_Homo sapiens_hsa049311.03723040
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02490477
60Shigellosis_Homo sapiens_hsa051311.02339405
61Bladder cancer_Homo sapiens_hsa052191.02056495
62Dilated cardiomyopathy_Homo sapiens_hsa054140.99163408
63Thyroid cancer_Homo sapiens_hsa052160.97864414
64Fructose and mannose metabolism_Homo sapiens_hsa000510.97093285
65Lysosome_Homo sapiens_hsa041420.96487459
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.93643987
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.92111103
68Base excision repair_Homo sapiens_hsa034100.87139621
69p53 signaling pathway_Homo sapiens_hsa041150.86880131
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.85822823
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85527628
72Apoptosis_Homo sapiens_hsa042100.84540604
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84051777
74Insulin signaling pathway_Homo sapiens_hsa049100.81961371
75One carbon pool by folate_Homo sapiens_hsa006700.81771840
76Alzheimers disease_Homo sapiens_hsa050100.78764319
77Complement and coagulation cascades_Homo sapiens_hsa046100.78700189
78Tryptophan metabolism_Homo sapiens_hsa003800.78632101
79HIF-1 signaling pathway_Homo sapiens_hsa040660.78328114
80Chronic myeloid leukemia_Homo sapiens_hsa052200.76456563
81Colorectal cancer_Homo sapiens_hsa052100.76158665
82Fatty acid metabolism_Homo sapiens_hsa012120.75846182
83Toxoplasmosis_Homo sapiens_hsa051450.75234002
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.74556131
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73037578
86Osteoclast differentiation_Homo sapiens_hsa043800.70760448
87Pyrimidine metabolism_Homo sapiens_hsa002400.70503019
88Phenylalanine metabolism_Homo sapiens_hsa003600.70439902
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69553031
90Focal adhesion_Homo sapiens_hsa045100.68688370
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68656695
92Acute myeloid leukemia_Homo sapiens_hsa052210.68611979
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68494447
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67976962
95Staphylococcus aureus infection_Homo sapiens_hsa051500.67528852
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.67416443
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66379251
98Pertussis_Homo sapiens_hsa051330.66297188
99Platelet activation_Homo sapiens_hsa046110.65898702
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.65668859
101VEGF signaling pathway_Homo sapiens_hsa043700.64810551
102Glucagon signaling pathway_Homo sapiens_hsa049220.63095470
103Cardiac muscle contraction_Homo sapiens_hsa042600.57355480
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57221941
105Peroxisome_Homo sapiens_hsa041460.56883058
106PPAR signaling pathway_Homo sapiens_hsa033200.56408277
107Caffeine metabolism_Homo sapiens_hsa002320.56001822
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53813928
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53345660
110Arginine biosynthesis_Homo sapiens_hsa002200.53113450
111Prostate cancer_Homo sapiens_hsa052150.53016985
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52476202
113Pancreatic cancer_Homo sapiens_hsa052120.52443637
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.52040486
115T cell receptor signaling pathway_Homo sapiens_hsa046600.51437822
116Prion diseases_Homo sapiens_hsa050200.50321134
117Sulfur metabolism_Homo sapiens_hsa009200.49996651
118Fat digestion and absorption_Homo sapiens_hsa049750.48856257
119Glycerolipid metabolism_Homo sapiens_hsa005610.47996657
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47306410
121Amoebiasis_Homo sapiens_hsa051460.46701034
122B cell receptor signaling pathway_Homo sapiens_hsa046620.46530066
123Epstein-Barr virus infection_Homo sapiens_hsa051690.45438270
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45203488
125Fatty acid elongation_Homo sapiens_hsa000620.44469772
126Herpes simplex infection_Homo sapiens_hsa051680.44443544
127HTLV-I infection_Homo sapiens_hsa051660.43667239
128Hepatitis B_Homo sapiens_hsa051610.43413091
129AMPK signaling pathway_Homo sapiens_hsa041520.43355378
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42858133
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42648896
132Measles_Homo sapiens_hsa051620.42091199
133Small cell lung cancer_Homo sapiens_hsa052220.41396280
134Influenza A_Homo sapiens_hsa051640.41273438
135* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40010546
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37913532
137FoxO signaling pathway_Homo sapiens_hsa040680.37740773
138Choline metabolism in cancer_Homo sapiens_hsa052310.37644224
139Linoleic acid metabolism_Homo sapiens_hsa005910.37328332
140Endometrial cancer_Homo sapiens_hsa052130.33037588
141Metabolic pathways_Homo sapiens_hsa011000.31908441
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.31551395
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30473140
144Glutathione metabolism_Homo sapiens_hsa004800.29887337
145mTOR signaling pathway_Homo sapiens_hsa041500.28353877
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27423990
147Hedgehog signaling pathway_Homo sapiens_hsa043400.27020981
148MicroRNAs in cancer_Homo sapiens_hsa052060.24583275
149Basal cell carcinoma_Homo sapiens_hsa052170.23964851
150Renal cell carcinoma_Homo sapiens_hsa052110.23855352
151Autoimmune thyroid disease_Homo sapiens_hsa053200.22124015
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19605083
153Oocyte meiosis_Homo sapiens_hsa041140.17379254
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16736896
155Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15812183
156Wnt signaling pathway_Homo sapiens_hsa043100.15455110
157Viral carcinogenesis_Homo sapiens_hsa052030.13336321

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