UBE2HP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of execution phase of apoptosis (GO:1900118)5.85219996
2ribosomal small subunit assembly (GO:0000028)5.40249762
3oxygen transport (GO:0015671)5.27053799
4maturation of SSU-rRNA (GO:0030490)5.17477288
5auditory receptor cell differentiation (GO:0042491)5.15742118
6regulation of sarcomere organization (GO:0060297)4.82657649
7neuronal stem cell maintenance (GO:0097150)4.75394937
8gas transport (GO:0015669)4.48181069
9embryonic retina morphogenesis in camera-type eye (GO:0060059)4.46824390
10establishment of mitochondrion localization (GO:0051654)4.42264599
11water-soluble vitamin biosynthetic process (GO:0042364)4.34173402
12spinal cord association neuron differentiation (GO:0021527)4.34139442
13ectodermal placode formation (GO:0060788)4.28484846
14regulation of telomere maintenance via telomerase (GO:0032210)4.26354673
15negative regulation of telomere maintenance (GO:0032205)4.11062742
16tongue development (GO:0043586)4.09491039
17mannosylation (GO:0097502)4.02754203
18postsynaptic membrane organization (GO:0001941)3.96435176
19protein polyglutamylation (GO:0018095)3.92446460
20ribonucleoprotein complex disassembly (GO:0032988)3.91248079
21viral transcription (GO:0019083)3.91226729
22forebrain neuron differentiation (GO:0021879)3.88403797
23ribosomal small subunit biogenesis (GO:0042274)3.85711225
24translational termination (GO:0006415)3.77746132
25preassembly of GPI anchor in ER membrane (GO:0016254)3.70615609
26negative regulation of potassium ion transmembrane transport (GO:1901380)3.67967884
27nonmotile primary cilium assembly (GO:0035058)3.66523839
28spliceosomal complex assembly (GO:0000245)3.61045620
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57024541
30positive regulation of respiratory burst (GO:0060267)3.47639038
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47319240
32negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.46513353
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38024447
34cotranslational protein targeting to membrane (GO:0006613)3.37726143
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.37703074
36regulation of telomerase activity (GO:0051972)3.35550298
37protein neddylation (GO:0045116)3.35367646
38cell proliferation in forebrain (GO:0021846)3.34671676
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.34546335
40mitochondrion transport along microtubule (GO:0047497)3.34546335
41pyrimidine nucleobase catabolic process (GO:0006208)3.30371730
42tachykinin receptor signaling pathway (GO:0007217)3.29811497
43translational elongation (GO:0006414)3.28023995
44response to gravity (GO:0009629)3.24622784
45protein targeting to ER (GO:0045047)3.23216714
46peptidyl-histidine modification (GO:0018202)3.22469644
47presynaptic membrane organization (GO:0097090)3.20619896
48protein localization to synapse (GO:0035418)3.18485689
49presynaptic membrane assembly (GO:0097105)3.15262530
50ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.10940940
51cardiovascular system development (GO:0072358)3.10748282
52dendritic spine morphogenesis (GO:0060997)3.09853622
53behavioral response to cocaine (GO:0048148)3.09440472
54cellular response to vitamin D (GO:0071305)3.07943287
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07160876
56regulation of cilium movement (GO:0003352)3.06967591
57protein localization to endoplasmic reticulum (GO:0070972)3.00713726
58viral life cycle (GO:0019058)2.95617259
59N-glycan processing (GO:0006491)2.95402473
60short-term memory (GO:0007614)2.94949357
61C-terminal protein lipidation (GO:0006501)2.94401717
62cerebellar granule cell differentiation (GO:0021707)2.92524020
63auditory behavior (GO:0031223)2.91456106
64negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90561679
65inner ear receptor cell differentiation (GO:0060113)2.90007657
66ATP synthesis coupled proton transport (GO:0015986)2.89890939
67energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89890939
68cellular protein complex disassembly (GO:0043624)2.87039681
69negative regulation of glycogen metabolic process (GO:0070874)2.86843275
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86019389
71neurotransmitter-gated ion channel clustering (GO:0072578)2.84821900
72regulation of type B pancreatic cell apoptotic process (GO:2000674)2.84602758
73translational initiation (GO:0006413)2.79654414
74C-terminal protein amino acid modification (GO:0018410)2.78646296
75regulation of microtubule-based movement (GO:0060632)2.74714022
76chemosensory behavior (GO:0007635)2.74505335
77sequestering of actin monomers (GO:0042989)2.74434435
78establishment of tissue polarity (GO:0007164)2.73510283
79establishment of planar polarity (GO:0001736)2.73510283
80lymphangiogenesis (GO:0001946)2.72326915
81organelle disassembly (GO:1903008)2.72263186
82protein complex biogenesis (GO:0070271)2.71352086
83primitive streak formation (GO:0090009)2.70820831
84S-adenosylmethionine metabolic process (GO:0046500)2.69918172
85biotin metabolic process (GO:0006768)2.68594442
86response to redox state (GO:0051775)2.68588854
87behavioral response to nicotine (GO:0035095)2.66494098
88axonal fasciculation (GO:0007413)2.65357214
89neuron cell-cell adhesion (GO:0007158)2.64589936
90nucleobase catabolic process (GO:0046113)2.64315235
91regulation of bile acid biosynthetic process (GO:0070857)2.63953277
92positive regulation of Notch signaling pathway (GO:0045747)2.63422644
93response to auditory stimulus (GO:0010996)2.63000036
94cornea development in camera-type eye (GO:0061303)2.62692367
95regulation of G0 to G1 transition (GO:0070316)2.61699586
96macromolecular complex disassembly (GO:0032984)2.59793604
97hair cell differentiation (GO:0035315)2.58743601
98head development (GO:0060322)2.57199778
99protein K6-linked ubiquitination (GO:0085020)2.56797901
100NADH dehydrogenase complex assembly (GO:0010257)2.56674677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.39302663
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.82247334
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.56233079
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.08920469
5VDR_22108803_ChIP-Seq_LS180_Human3.78321483
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.58286196
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04573562
8IGF1R_20145208_ChIP-Seq_DFB_Human3.03807563
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.94589073
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90589173
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68371378
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.66130455
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.54073652
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42032443
15IRF1_19129219_ChIP-ChIP_H3396_Human2.29253119
16SOX2_16153702_ChIP-ChIP_HESCs_Human2.26508518
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11047171
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98577851
19ZNF274_21170338_ChIP-Seq_K562_Hela1.91400083
20MYC_18940864_ChIP-ChIP_HL60_Human1.87122007
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86342328
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84560284
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82106029
24TP53_22573176_ChIP-Seq_HFKS_Human1.81636815
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.79918302
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.79052188
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.66333171
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65730999
29RNF2_27304074_Chip-Seq_NSC_Mouse1.62046802
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.52145389
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50086410
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48878139
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.46421743
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42846580
35GBX2_23144817_ChIP-Seq_PC3_Human1.42642718
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39540857
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38692428
38EWS_26573619_Chip-Seq_HEK293_Human1.37495991
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31712743
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30903518
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23629804
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23006396
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22992721
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.22066599
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18106584
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.18010603
47REST_21632747_ChIP-Seq_MESCs_Mouse1.17463058
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.16811341
49HTT_18923047_ChIP-ChIP_STHdh_Human1.16782710
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14462341
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.14145915
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10111850
53SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09538697
54FUS_26573619_Chip-Seq_HEK293_Human1.07497746
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05939474
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04682906
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04029969
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03842549
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.03648416
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01033878
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99567825
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99366740
63P300_19829295_ChIP-Seq_ESCs_Human0.99179510
64POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97160278
65TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96533526
66MYC_19829295_ChIP-Seq_ESCs_Human0.96301958
67VDR_23849224_ChIP-Seq_CD4+_Human0.95206419
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93716187
69RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92328984
70EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92328984
71RNF2_27304074_Chip-Seq_ESCs_Mouse0.91919645
72ELF1_20517297_ChIP-Seq_JURKAT_Human0.91827637
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91707384
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91340786
75AR_20517297_ChIP-Seq_VCAP_Human0.90743402
76GATA3_21878914_ChIP-Seq_MCF-7_Human0.88428021
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87191151
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87191151
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85625321
80WDR5_24793694_ChIP-Seq_LNCAP_Human0.85606864
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84613915
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82914120
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82353908
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82249000
85GABP_19822575_ChIP-Seq_HepG2_Human0.81274619
86SALL4_22934838_ChIP-ChIP_CD34+_Human0.80514151
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79755359
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78997773
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78685917
90ELK1_19687146_ChIP-ChIP_HELA_Human0.78407403
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78248363
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.76614286
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.75104249
94GATA3_21867929_ChIP-Seq_TH1_Mouse0.74665744
95XRN2_22483619_ChIP-Seq_HELA_Human0.74431272
96DCP1A_22483619_ChIP-Seq_HELA_Human0.73471628
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.72955424
98CREB1_15753290_ChIP-ChIP_HEK293T_Human0.71669421
99SOX9_26525672_Chip-Seq_HEART_Mouse0.71595659
100TDRD3_21172665_ChIP-Seq_MCF-7_Human0.71435853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.72255396
2MP0000015_abnormal_ear_pigmentation3.41194155
3MP0003880_abnormal_central_pattern3.40951673
4MP0005645_abnormal_hypothalamus_physiol3.34970710
5MP0002653_abnormal_ependyma_morphology2.78361547
6MP0009379_abnormal_foot_pigmentation2.78248513
7MP0000566_synostosis2.72436232
8MP0002277_abnormal_respiratory_mucosa2.58768098
9MP0006276_abnormal_autonomic_nervous2.39641385
10MP0003122_maternal_imprinting2.28251331
11MP0003878_abnormal_ear_physiology2.24041927
12MP0005377_hearing/vestibular/ear_phenot2.24041927
13MP0000778_abnormal_nervous_system2.22729876
14MP0002163_abnormal_gland_morphology2.20088339
15MP0001986_abnormal_taste_sensitivity2.14803282
16MP0004145_abnormal_muscle_electrophysio2.14147546
17MP0001485_abnormal_pinna_reflex2.10319660
18MP0002095_abnormal_skin_pigmentation1.96672382
19MP0006292_abnormal_olfactory_placode1.82644813
20MP0001529_abnormal_vocalization1.68616764
21MP0003787_abnormal_imprinting1.67610664
22MP0001293_anophthalmia1.65215495
23MP0009046_muscle_twitch1.60104611
24MP0002938_white_spotting1.57429206
25MP0004133_heterotaxia1.56720892
26MP0001984_abnormal_olfaction1.54394647
27MP0003183_abnormal_peptide_metabolism1.53538532
28MP0004742_abnormal_vestibular_system1.52974201
29MP0000631_abnormal_neuroendocrine_gland1.52345813
30MP0004270_analgesia1.50210575
31MP0003011_delayed_dark_adaptation1.47445874
32MP0004142_abnormal_muscle_tone1.41587172
33MP0008877_abnormal_DNA_methylation1.36184877
34MP0003938_abnormal_ear_development1.34692987
35MP0003121_genomic_imprinting1.34178706
36MP0008789_abnormal_olfactory_epithelium1.32766246
37MP0000955_abnormal_spinal_cord1.32321756
38MP0005423_abnormal_somatic_nervous1.31972443
39MP0005499_abnormal_olfactory_system1.31735594
40MP0005394_taste/olfaction_phenotype1.31735594
41MP0002272_abnormal_nervous_system1.30300188
42MP0002876_abnormal_thyroid_physiology1.27701016
43MP0005084_abnormal_gallbladder_morpholo1.26954716
44MP0002184_abnormal_innervation1.24020400
45MP0001727_abnormal_embryo_implantation1.23950632
46MP0005379_endocrine/exocrine_gland_phen1.23800397
47MP0002822_catalepsy1.22431159
48MP0004885_abnormal_endolymph1.20053265
49MP0001905_abnormal_dopamine_level1.17076598
50MP0001502_abnormal_circadian_rhythm1.16634739
51MP0008872_abnormal_physiological_respon1.14780433
52MP0002751_abnormal_autonomic_nervous1.14645516
53MP0009745_abnormal_behavioral_response1.13354404
54MP0010368_abnormal_lymphatic_system1.13020087
55MP0000026_abnormal_inner_ear1.10643261
56MP0003283_abnormal_digestive_organ1.09162312
57MP0002063_abnormal_learning/memory/cond1.09125355
58MP0004147_increased_porphyrin_level1.08973774
59MP0002882_abnormal_neuron_morphology1.08508251
60MP0002928_abnormal_bile_duct1.08174458
61MP0002752_abnormal_somatic_nervous1.06763006
62MP0004811_abnormal_neuron_physiology1.05591256
63MP0003879_abnormal_hair_cell1.03618717
64MP0002177_abnormal_outer_ear1.02891238
65MP0008995_early_reproductive_senescence1.02750725
66MP0002572_abnormal_emotion/affect_behav0.98047283
67MP0003635_abnormal_synaptic_transmissio0.96369384
68MP0002557_abnormal_social/conspecific_i0.96278413
69MP0002734_abnormal_mechanical_nocicepti0.95848863
70MP0008058_abnormal_DNA_repair0.95366034
71MP0002067_abnormal_sensory_capabilities0.94126718
72MP0002127_abnormal_cardiovascular_syste0.92558864
73MP0002282_abnormal_trachea_morphology0.91630748
74MP0003755_abnormal_palate_morphology0.90501030
75MP0004859_abnormal_synaptic_plasticity0.88544610
76MP0006072_abnormal_retinal_apoptosis0.87725054
77MP0002837_dystrophic_cardiac_calcinosis0.84212620
78MP0002152_abnormal_brain_morphology0.84202552
79MP0005551_abnormal_eye_electrophysiolog0.83368363
80MP0002735_abnormal_chemical_nociception0.81559051
81MP0001963_abnormal_hearing_physiology0.81062941
82MP0005195_abnormal_posterior_eye0.78808208
83MP0001968_abnormal_touch/_nociception0.78174722
84MP0003942_abnormal_urinary_system0.77626538
85MP0001324_abnormal_eye_pigmentation0.76722837
86MP0002102_abnormal_ear_morphology0.76672760
87MP0001286_abnormal_eye_development0.76641944
88MP0006054_spinal_hemorrhage0.76371931
89MP0005167_abnormal_blood-brain_barrier0.74403659
90MP0002064_seizures0.74296442
91MP0002736_abnormal_nociception_after0.74280865
92MP0002132_abnormal_respiratory_system0.73925111
93MP0005253_abnormal_eye_physiology0.71864870
94MP0002234_abnormal_pharynx_morphology0.70856450
95MP0001542_abnormal_bone_strength0.70685925
96MP0001944_abnormal_pancreas_morphology0.69695138
97MP0002229_neurodegeneration0.69533596
98MP0000230_abnormal_systemic_arterial0.69396472
99MP0000372_irregular_coat_pigmentation0.68416256
100MP0003935_abnormal_craniofacial_develop0.66632882

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)5.76711958
2Tubulointerstitial nephritis (HP:0001970)5.05036817
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.44586815
4Acute necrotizing encephalopathy (HP:0006965)4.35489800
5Abnormal mitochondria in muscle tissue (HP:0008316)3.91228380
6Tubular atrophy (HP:0000092)3.78074686
7Septo-optic dysplasia (HP:0100842)3.73055486
8Acute encephalopathy (HP:0006846)3.68589978
9Progressive macrocephaly (HP:0004481)3.51758480
10Hip dysplasia (HP:0001385)3.44240052
11Stenosis of the external auditory canal (HP:0000402)3.38002168
12Myokymia (HP:0002411)3.34821637
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.33503740
14Maternal diabetes (HP:0009800)3.20023989
15Abnormality of cells of the erythroid lineage (HP:0012130)3.19465192
16Nephronophthisis (HP:0000090)3.18766925
17Pancreatic fibrosis (HP:0100732)3.05749516
18Hepatic necrosis (HP:0002605)2.99390377
19Pallor (HP:0000980)2.95151346
20Overriding aorta (HP:0002623)2.89423182
21Polyphagia (HP:0002591)2.87805366
22Mitochondrial inheritance (HP:0001427)2.86226055
23Reticulocytopenia (HP:0001896)2.85737598
24Abnormality of the diencephalon (HP:0010662)2.82487177
25Hyperglycinemia (HP:0002154)2.76298374
26Hepatocellular necrosis (HP:0001404)2.75630924
27Abnormality of the renal medulla (HP:0100957)2.75289993
28Anencephaly (HP:0002323)2.74822326
29Tubulointerstitial abnormality (HP:0001969)2.74072488
30Pancreatic cysts (HP:0001737)2.73108081
31Increased CSF lactate (HP:0002490)2.71341515
32Homocystinuria (HP:0002156)2.66754404
33Abnormality of homocysteine metabolism (HP:0010919)2.66754404
34Medial flaring of the eyebrow (HP:0010747)2.66630336
35Anophthalmia (HP:0000528)2.63709890
36Cerebral edema (HP:0002181)2.63363758
37Hypothermia (HP:0002045)2.62723770
38Absent septum pellucidum (HP:0001331)2.57798376
39Partial duplication of thumb phalanx (HP:0009944)2.57084241
4011 pairs of ribs (HP:0000878)2.53826021
41Optic nerve hypoplasia (HP:0000609)2.52886417
42Supernumerary spleens (HP:0009799)2.50026888
43Hyperventilation (HP:0002883)2.49563230
44Nephrogenic diabetes insipidus (HP:0009806)2.48139245
45Elfin facies (HP:0004428)2.46715501
46Severe muscular hypotonia (HP:0006829)2.43193456
47Molar tooth sign on MRI (HP:0002419)2.41829686
48Abnormality of midbrain morphology (HP:0002418)2.41829686
49Abnormality of the labia minora (HP:0012880)2.40182392
50Rib fusion (HP:0000902)2.37465285
51Sclerocornea (HP:0000647)2.32047958
52Microcytic anemia (HP:0001935)2.28173500
53Retinal dysplasia (HP:0007973)2.27808800
54True hermaphroditism (HP:0010459)2.22064851
55Abnormal number of erythroid precursors (HP:0012131)2.21669556
56Gait imbalance (HP:0002141)2.21423465
57Microvesicular hepatic steatosis (HP:0001414)2.19628183
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19493061
59Albinism (HP:0001022)2.17737790
60Abnormality of reticulocytes (HP:0004312)2.16510581
61Abnormal hair whorl (HP:0010721)2.14251510
62Methylmalonic acidemia (HP:0002912)2.11968942
63Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.10667395
64Congenital primary aphakia (HP:0007707)2.08931809
65Abnormality of the septum pellucidum (HP:0007375)2.07830988
66Vaginal atresia (HP:0000148)2.04845173
67Abnormal pancreas size (HP:0012094)2.04234697
68Partial duplication of the phalanx of hand (HP:0009999)2.03106323
69Hypogonadotrophic hypogonadism (HP:0000044)2.02938440
70Insomnia (HP:0100785)2.01193487
71Spinal muscular atrophy (HP:0007269)1.99619579
72Hypochromic anemia (HP:0001931)1.98169572
73Broad distal phalanx of finger (HP:0009836)1.96208000
74Microretrognathia (HP:0000308)1.95105077
75Pachygyria (HP:0001302)1.95078448
76Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.94943919
77Vertebral hypoplasia (HP:0008417)1.94943919
78Genital tract atresia (HP:0001827)1.94872013
79Tachypnea (HP:0002789)1.94352127
80Lethargy (HP:0001254)1.93742401
81Methylmalonic aciduria (HP:0012120)1.91764115
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.91426919
83Renovascular hypertension (HP:0100817)1.91021428
84Flat capital femoral epiphysis (HP:0003370)1.89628377
85Degeneration of anterior horn cells (HP:0002398)1.88995206
86Abnormality of the anterior horn cell (HP:0006802)1.88995206
87Macrocytic anemia (HP:0001972)1.88348826
88Oligodactyly (HP:0012165)1.87379574
89Cystic liver disease (HP:0006706)1.86528928
90Optic disc pallor (HP:0000543)1.86181797
91Reticulocytosis (HP:0001923)1.83718836
92Patent foramen ovale (HP:0001655)1.80736893
93Missing ribs (HP:0000921)1.78813299
94Hypoplasia of the brainstem (HP:0002365)1.78329216
95Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78329216
96Esotropia (HP:0000565)1.77717965
97Humeroradial synostosis (HP:0003041)1.77318304
98Synostosis involving the elbow (HP:0003938)1.77318304
99Esophageal atresia (HP:0002032)1.76898986
100Leukodystrophy (HP:0002415)1.76103703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.55602640
2BMPR1B3.78854328
3ZAK3.02116745
4WNK42.82046933
5STK392.68948844
6PDK22.54383683
7VRK12.40364283
8MAP3K92.32110743
9DYRK22.29727762
10MAP3K42.27710799
11KSR12.25945032
12TLK12.10462500
13MARK11.96876730
14PAK31.94316120
15MAP2K71.77904351
16WNK31.67141175
17EPHB21.65243550
18SRPK11.57010629
19BCKDK1.56150752
20RPS6KA51.53528861
21DMPK1.46092532
22LRRK21.45499354
23CCNB11.44773613
24BCR1.44121725
25MAPK131.41941502
26MAP4K21.39215725
27CSNK1G31.35625988
28DYRK31.35611401
29CSNK1G21.23898226
30TRIM281.17183185
31STK241.15815352
32NME11.14719868
33BRAF1.14218352
34EPHA41.13646523
35KSR21.13613394
36MOS1.12659033
37GRK11.09522137
38NEK11.06838129
39ARAF1.03709902
40PRKCG1.01379120
41CSNK1G10.98633947
42PASK0.97650186
43ABL20.97617012
44EPHA30.93072954
45CDC70.88863492
46PHKG20.87631797
47PHKG10.87631797
48PKN10.85022367
49PAK60.82698153
50PRKCQ0.80196238
51PAK20.78108908
52AURKA0.72063388
53DYRK1B0.71686839
54WNK10.71128292
55DAPK30.70001742
56BLK0.69063900
57IRAK10.67850365
58LIMK10.67477527
59FGFR10.67383407
60CAMK2D0.65539050
61SIK20.64699877
62PRKAA10.64060150
63PRKCE0.64040340
64CSNK1E0.63700703
65ADRBK10.62687162
66MAP3K50.61406597
67CAMK2A0.60948483
68CSNK1A1L0.59521129
69CAMK2B0.58771813
70RPS6KA20.57724404
71CAMK2G0.53169280
72AURKB0.51707237
73RAF10.51456770
74TAF10.51277549
75RPS6KA40.50290537
76PRKACA0.50272797
77TAOK30.50209577
78CHUK0.46056538
79CSNK2A20.45606654
80PRKG10.45482479
81EGFR0.42188132
82DYRK1A0.41695689
83ADRBK20.41233166
84CSF1R0.40945804
85CDK50.40114783
86CSNK1A10.39924099
87MAPK90.39391980
88MAP2K10.38912994
89EPHB10.38888392
90PRKCZ0.37795289
91PINK10.36254240
92ERBB20.35529812
93PRKCH0.35217959
94CAMK10.34606053
95PRKCB0.34206486
96PLK20.32397512
97STK40.32268276
98MAP2K40.31037962
99MINK10.29424141
100VRK20.28871622

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.09264749
2Oxidative phosphorylation_Homo sapiens_hsa001903.99313273
3Systemic lupus erythematosus_Homo sapiens_hsa053223.97660284
4Alcoholism_Homo sapiens_hsa050343.48839092
5Parkinsons disease_Homo sapiens_hsa050123.35512632
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.23172436
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66548704
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.36029037
9Huntingtons disease_Homo sapiens_hsa050162.35003471
10Nicotine addiction_Homo sapiens_hsa050332.29412883
11Cardiac muscle contraction_Homo sapiens_hsa042602.26513780
12Protein export_Homo sapiens_hsa030602.17117572
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17041012
14Alzheimers disease_Homo sapiens_hsa050102.08742407
15Sulfur metabolism_Homo sapiens_hsa009202.01893094
16Collecting duct acid secretion_Homo sapiens_hsa049661.95298929
17Steroid biosynthesis_Homo sapiens_hsa001001.93235461
18Basal transcription factors_Homo sapiens_hsa030221.92385076
19Proteasome_Homo sapiens_hsa030501.68341986
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63673707
21Sulfur relay system_Homo sapiens_hsa041221.59978982
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56720957
23GABAergic synapse_Homo sapiens_hsa047271.53499390
24Synaptic vesicle cycle_Homo sapiens_hsa047211.45872318
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42049429
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39444667
27Insulin secretion_Homo sapiens_hsa049111.32546248
28RNA degradation_Homo sapiens_hsa030181.24160056
29Base excision repair_Homo sapiens_hsa034101.19031589
30Phototransduction_Homo sapiens_hsa047441.17995674
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14759795
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11604861
33Butanoate metabolism_Homo sapiens_hsa006501.09234244
34Glutamatergic synapse_Homo sapiens_hsa047241.03528900
35Fanconi anemia pathway_Homo sapiens_hsa034600.96632488
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94692818
37Axon guidance_Homo sapiens_hsa043600.94673806
38Hedgehog signaling pathway_Homo sapiens_hsa043400.94581728
39Propanoate metabolism_Homo sapiens_hsa006400.93971927
40One carbon pool by folate_Homo sapiens_hsa006700.93917302
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92541719
42Regulation of autophagy_Homo sapiens_hsa041400.90405450
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89164732
44Morphine addiction_Homo sapiens_hsa050320.85486162
45Basal cell carcinoma_Homo sapiens_hsa052170.85222091
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.82071978
47Cocaine addiction_Homo sapiens_hsa050300.80858159
48Notch signaling pathway_Homo sapiens_hsa043300.79741274
49Dopaminergic synapse_Homo sapiens_hsa047280.79677569
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74729867
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71886641
52Hippo signaling pathway_Homo sapiens_hsa043900.67765318
53N-Glycan biosynthesis_Homo sapiens_hsa005100.65419156
54Nitrogen metabolism_Homo sapiens_hsa009100.64527438
55Metabolic pathways_Homo sapiens_hsa011000.63662650
56Peroxisome_Homo sapiens_hsa041460.63009819
57Viral carcinogenesis_Homo sapiens_hsa052030.62804845
58Dorso-ventral axis formation_Homo sapiens_hsa043200.61469921
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59976940
60Long-term depression_Homo sapiens_hsa047300.57390722
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53957428
62Serotonergic synapse_Homo sapiens_hsa047260.52553046
63Vibrio cholerae infection_Homo sapiens_hsa051100.51335233
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48597665
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47094134
66Spliceosome_Homo sapiens_hsa030400.46933582
67Amphetamine addiction_Homo sapiens_hsa050310.46629417
68Folate biosynthesis_Homo sapiens_hsa007900.46576141
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46069959
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43899498
71RNA polymerase_Homo sapiens_hsa030200.43163266
72Selenocompound metabolism_Homo sapiens_hsa004500.41237810
73RNA transport_Homo sapiens_hsa030130.41013424
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40604128
75Circadian entrainment_Homo sapiens_hsa047130.39042907
76Retinol metabolism_Homo sapiens_hsa008300.37824581
77Tryptophan metabolism_Homo sapiens_hsa003800.36935194
78Linoleic acid metabolism_Homo sapiens_hsa005910.36402066
79Circadian rhythm_Homo sapiens_hsa047100.36303472
80Melanogenesis_Homo sapiens_hsa049160.36012882
81Gap junction_Homo sapiens_hsa045400.35990874
82Asthma_Homo sapiens_hsa053100.35892012
83Sphingolipid metabolism_Homo sapiens_hsa006000.34535950
84Nucleotide excision repair_Homo sapiens_hsa034200.34415863
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34177431
86Cholinergic synapse_Homo sapiens_hsa047250.32948676
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32911191
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32683607
89Rheumatoid arthritis_Homo sapiens_hsa053230.30565634
90beta-Alanine metabolism_Homo sapiens_hsa004100.30390328
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26803749
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26102296
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.25546666
94Wnt signaling pathway_Homo sapiens_hsa043100.25425404
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24485501
96Pyruvate metabolism_Homo sapiens_hsa006200.22418889
97Homologous recombination_Homo sapiens_hsa034400.18498682
98Oocyte meiosis_Homo sapiens_hsa041140.18419852
99Chemical carcinogenesis_Homo sapiens_hsa052040.16950043
100Phagosome_Homo sapiens_hsa041450.16370673

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