UBE2I

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.53277396
2DNA strand elongation involved in DNA replication (GO:0006271)4.36518821
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.22572217
4DNA strand elongation (GO:0022616)4.18020239
5peptidyl-arginine omega-N-methylation (GO:0035247)4.17270884
6protein localization to kinetochore (GO:0034501)4.14793734
7ribosomal small subunit assembly (GO:0000028)4.10608848
8macromolecular complex disassembly (GO:0032984)4.08762615
9telomere maintenance via semi-conservative replication (GO:0032201)4.06836306
10DNA replication initiation (GO:0006270)4.01633154
11establishment of integrated proviral latency (GO:0075713)3.99929324
12negative regulation of DNA-templated transcription, elongation (GO:0032785)3.88471711
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.83131081
14mitotic nuclear envelope disassembly (GO:0007077)3.82789886
15heterochromatin organization (GO:0070828)3.81018510
16telomere maintenance via recombination (GO:0000722)3.72815073
17viral transcription (GO:0019083)3.70461051
18maturation of SSU-rRNA (GO:0030490)3.67288649
19protein localization to chromosome, centromeric region (GO:0071459)3.67020570
20DNA replication-dependent nucleosome organization (GO:0034723)3.66040121
21DNA replication-dependent nucleosome assembly (GO:0006335)3.66040121
22mitotic recombination (GO:0006312)3.63858857
23formation of translation preinitiation complex (GO:0001731)3.63757100
24translational termination (GO:0006415)3.63457794
25establishment of viral latency (GO:0019043)3.61829709
26negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.61620585
27protein-DNA complex disassembly (GO:0032986)3.60849176
28nucleosome disassembly (GO:0006337)3.60849176
29nuclear envelope disassembly (GO:0051081)3.55462008
30membrane disassembly (GO:0030397)3.55462008
31histone arginine methylation (GO:0034969)3.54323008
32mitotic metaphase plate congression (GO:0007080)3.52254936
33mitotic chromosome condensation (GO:0007076)3.51207524
34nuclear pore organization (GO:0006999)3.49575998
35DNA replication checkpoint (GO:0000076)3.48607106
36CENP-A containing nucleosome assembly (GO:0034080)3.41760104
37nuclear pore complex assembly (GO:0051292)3.39898197
38DNA replication-independent nucleosome organization (GO:0034724)3.37857225
39DNA replication-independent nucleosome assembly (GO:0006336)3.37857225
40chromatin remodeling at centromere (GO:0031055)3.35765465
41translational elongation (GO:0006414)3.35756201
42protein targeting to membrane (GO:0006612)3.35445675
43nuclear envelope reassembly (GO:0031468)3.35425517
44mitotic nuclear envelope reassembly (GO:0007084)3.35425517
45peptidyl-arginine methylation (GO:0018216)3.35300993
46peptidyl-arginine N-methylation (GO:0035246)3.35300993
47folic acid-containing compound biosynthetic process (GO:0009396)3.33512129
48pyrimidine nucleotide catabolic process (GO:0006244)3.32757063
49DNA deamination (GO:0045006)3.31849258
50regulation of mammary gland epithelial cell proliferation (GO:0033599)3.30314901
51translational initiation (GO:0006413)3.30035455
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28704212
53spliceosomal tri-snRNP complex assembly (GO:0000244)3.28641807
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27844668
55telomere maintenance via telomere lengthening (GO:0010833)3.25756932
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.25532938
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22738392
58negative regulation of RNA splicing (GO:0033119)3.22490805
59nucleobase biosynthetic process (GO:0046112)3.21427338
60kinetochore organization (GO:0051383)3.21067197
61mitotic sister chromatid segregation (GO:0000070)3.20316674
62pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20293507
633-UTR-mediated mRNA stabilization (GO:0070935)3.19983178
64mRNA catabolic process (GO:0006402)3.18749747
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17620956
66negative regulation of B cell apoptotic process (GO:0002903)3.16749960
67ribosomal small subunit biogenesis (GO:0042274)3.16028926
68translation (GO:0006412)3.13683557
69sister chromatid segregation (GO:0000819)3.13648923
70regulation of spindle organization (GO:0090224)3.11975888
71metaphase plate congression (GO:0051310)3.10969897
72RNA catabolic process (GO:0006401)3.08886574
73DNA duplex unwinding (GO:0032508)3.07312472
74attachment of spindle microtubules to kinetochore (GO:0008608)3.07007913
75DNA geometric change (GO:0032392)3.05088571
76UV protection (GO:0009650)3.04097340
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.00026030
78IMP biosynthetic process (GO:0006188)2.98945874
79chromatin assembly or disassembly (GO:0006333)2.95388531
80deoxyribonucleotide catabolic process (GO:0009264)2.95329725
81negative regulation of mRNA metabolic process (GO:1903312)2.94602242
82establishment of chromosome localization (GO:0051303)2.93834975
83translesion synthesis (GO:0019985)2.92293244
84regulation of sister chromatid cohesion (GO:0007063)2.91245299
85ribosomal large subunit biogenesis (GO:0042273)2.90397507
86viral life cycle (GO:0019058)2.89319115
87purine nucleobase biosynthetic process (GO:0009113)2.89185327
88protein targeting to ER (GO:0045047)2.88653064
89cotranslational protein targeting to membrane (GO:0006613)2.88556926
90histone exchange (GO:0043486)2.87960432
91ribosome assembly (GO:0042255)2.87873588
92negative regulation of chromosome segregation (GO:0051985)2.87801104
93ribonucleoprotein complex biogenesis (GO:0022613)2.87626542
94cellular protein complex disassembly (GO:0043624)2.87421641
95regulation of chromosome segregation (GO:0051983)2.86658997
96negative regulation of mitotic sister chromatid separation (GO:2000816)2.86557702
97negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86557702
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86557702
99negative regulation of sister chromatid segregation (GO:0033046)2.86557702
100mRNA splicing, via spliceosome (GO:0000398)2.85866368
101RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85866368
102RNA splicing, via transesterification reactions (GO:0000375)2.84605934
103base-excision repair (GO:0006284)2.84331773
104postreplication repair (GO:0006301)2.83758801
105mitotic sister chromatid cohesion (GO:0007064)2.83278956
106ribosome biogenesis (GO:0042254)2.82741224
107kinetochore assembly (GO:0051382)2.82632862
108ATP-dependent chromatin remodeling (GO:0043044)2.82540669
109protein maturation by protein folding (GO:0022417)2.81642549
110dosage compensation (GO:0007549)2.81351791
111spindle assembly checkpoint (GO:0071173)2.81213658
112spindle checkpoint (GO:0031577)2.81045509
113viral mRNA export from host cell nucleus (GO:0046784)2.80611573
114mitotic spindle assembly checkpoint (GO:0007094)2.80187256
115deoxyribose phosphate catabolic process (GO:0046386)2.78969571
116nuclear envelope organization (GO:0006998)2.78821370
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78454472
118protein localization to chromosome (GO:0034502)2.77873058
119histone H2A acetylation (GO:0043968)2.77766408
120spliceosomal snRNP assembly (GO:0000387)2.77158087
121cellular component biogenesis (GO:0044085)2.76470472
122negative regulation of mRNA processing (GO:0050686)2.75118598
123termination of RNA polymerase II transcription (GO:0006369)2.74977778
124protein complex disassembly (GO:0043241)2.74228522
125nuclear-transcribed mRNA catabolic process (GO:0000956)2.74061726
126positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.73619515
127establishment of protein localization to endoplasmic reticulum (GO:0072599)2.72906957
128DNA topological change (GO:0006265)2.72164351
129regulation of mitotic metaphase/anaphase transition (GO:0030071)2.71586535
130NIK/NF-kappaB signaling (GO:0038061)2.70908555
131negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70836237
132pentose metabolic process (GO:0019321)2.70481153
133pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.70185780
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70041638
135mitotic spindle checkpoint (GO:0071174)2.69875233
136pentose-phosphate shunt (GO:0006098)2.69456929
137telomere maintenance (GO:0000723)2.69149620
138positive regulation of chromosome segregation (GO:0051984)2.68862196
139COPI coating of Golgi vesicle (GO:0048205)2.68440859
140Golgi transport vesicle coating (GO:0048200)2.68440859
141telomere organization (GO:0032200)2.67866446
142T cell apoptotic process (GO:0070231)2.67262197
143protein localization to endoplasmic reticulum (GO:0070972)2.66990663
144protein retention in ER lumen (GO:0006621)2.66729500
145IMP metabolic process (GO:0046040)2.65730814
146GDP-mannose metabolic process (GO:0019673)2.65589861
147chromatin assembly (GO:0031497)2.62937418
148regulation of mitochondrial translation (GO:0070129)2.60575692
149purine deoxyribonucleotide catabolic process (GO:0009155)2.59483468
150proline biosynthetic process (GO:0006561)2.58730015
151transcription-coupled nucleotide-excision repair (GO:0006283)2.58023542
152metallo-sulfur cluster assembly (GO:0031163)2.57732010
153iron-sulfur cluster assembly (GO:0016226)2.57732010
154pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.56810798
155maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55046417
156regulation of translational fidelity (GO:0006450)2.52281615
157positive regulation of receptor biosynthetic process (GO:0010870)2.51669010
158nucleobase-containing small molecule interconversion (GO:0015949)2.48231620
159base-excision repair, AP site formation (GO:0006285)2.47747743
160rRNA processing (GO:0006364)2.45352379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.53512345
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32113282
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.91022577
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59820947
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59245845
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16817762
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74976363
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.70273821
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54345651
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.48818874
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45027710
12MYC_22102868_ChIP-Seq_BL_Human2.32321177
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.30898946
14XRN2_22483619_ChIP-Seq_HELA_Human2.30491684
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29964688
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.27352131
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24494328
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21793723
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14980622
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11170893
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.06271157
22AR_21909140_ChIP-Seq_LNCAP_Human2.04471809
23VDR_23849224_ChIP-Seq_CD4+_Human1.99502498
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99327469
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97091087
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85532378
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85130621
28CIITA_25753668_ChIP-Seq_RAJI_Human1.83741220
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81604235
30LXR_22292898_ChIP-Seq_THP-1_Human1.76926372
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74933643
32DCP1A_22483619_ChIP-Seq_HELA_Human1.74854990
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74821065
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.73903836
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70876499
36GABP_19822575_ChIP-Seq_HepG2_Human1.70681560
37TTF2_22483619_ChIP-Seq_HELA_Human1.70420704
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64846797
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64749110
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62155711
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58285782
42* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56890058
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56583713
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56310704
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51651033
46VDR_21846776_ChIP-Seq_THP-1_Human1.51551079
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51447579
48ELK1_19687146_ChIP-ChIP_HELA_Human1.51011292
49ZNF263_19887448_ChIP-Seq_K562_Human1.49361300
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.45409491
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.45245597
52KDM5A_27292631_Chip-Seq_BREAST_Human1.45068073
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43390638
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42443090
55* P68_20966046_ChIP-Seq_HELA_Human1.42388265
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42237005
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42202854
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40836768
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40354433
60* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40191948
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39278937
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39122342
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36962239
64* MAF_26560356_Chip-Seq_TH2_Human1.36739171
65* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34202742
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33617865
67* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33307249
68RACK7_27058665_Chip-Seq_MCF-7_Human1.31222462
69KDM2B_26808549_Chip-Seq_DND41_Human1.31197952
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30645209
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.28955575
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27817747
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26262194
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24944359
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23988269
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23159949
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22290281
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20863763
79TFEB_21752829_ChIP-Seq_HELA_Human1.19788930
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19743025
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.19352896
82VDR_24763502_ChIP-Seq_THP-1_Human1.16839569
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15623113
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15587688
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.14394070
86* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12194402
87* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11077163
88SPI1_23547873_ChIP-Seq_NB4_Human1.10910315
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10892558
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10818475
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.10605540
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10387613
93BCL6_27268052_Chip-Seq_Bcells_Human1.09118815
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.08581948
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08579981
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08395447
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07721321
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07635445
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07311694
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07269322
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.07253441
102NCOR1_26117541_ChIP-Seq_K562_Human1.06175893
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05239697
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04533280
105RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04253654
106* UTX_26944678_Chip-Seq_JUKART_Human1.03801064
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03299494
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.02548256
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02501308
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02398343
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01990782
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01632012
113BCOR_27268052_Chip-Seq_Bcells_Human1.00557653
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00554823
115MAF_26560356_Chip-Seq_TH1_Human1.00089106
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00021311
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99609611
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.98522631
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98019600
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.95933268
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94896663
122MYB_26560356_Chip-Seq_TH2_Human0.94803372
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94713342
124* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94555167
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93075955
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92654140
127MYB_26560356_Chip-Seq_TH1_Human0.91016869
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90075719
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.88036312
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86161331
131TCF7_22412390_ChIP-Seq_EML_Mouse0.85442648
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84617651
133RUNX1_22412390_ChIP-Seq_EML_Mouse0.81464631
134ELK3_25401928_ChIP-Seq_HUVEC_Human0.80866028
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80840874
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.79672071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.38650436
2MP0010094_abnormal_chromosome_stability3.81860294
3MP0003111_abnormal_nucleus_morphology3.63469770
4* MP0004957_abnormal_blastocyst_morpholog3.56290669
5MP0003077_abnormal_cell_cycle3.53419201
6MP0009379_abnormal_foot_pigmentation3.39444465
7MP0008057_abnormal_DNA_replication2.85309216
8MP0008007_abnormal_cellular_replicative2.76359627
9MP0010352_gastrointestinal_tract_polyps2.43234914
10MP0008058_abnormal_DNA_repair2.43177419
11MP0002396_abnormal_hematopoietic_system2.37441668
12MP0003123_paternal_imprinting2.15882189
13MP0001730_embryonic_growth_arrest2.13283665
14MP0000350_abnormal_cell_proliferation2.11012264
15MP0004185_abnormal_adipocyte_glucose2.09635215
16* MP0008932_abnormal_embryonic_tissue2.03124898
17MP0005451_abnormal_body_composition1.99259825
18MP0005058_abnormal_lysosome_morphology1.88608903
19MP0004808_abnormal_hematopoietic_stem1.88170815
20MP0003763_abnormal_thymus_physiology1.78832991
21MP0010307_abnormal_tumor_latency1.74996409
22MP0000490_abnormal_crypts_of1.70087735
23MP0004858_abnormal_nervous_system1.65082446
24MP0001697_abnormal_embryo_size1.64530765
25MP0010030_abnormal_orbit_morphology1.63214635
26MP0006054_spinal_hemorrhage1.61254932
27MP0005380_embryogenesis_phenotype1.59199634
28MP0001672_abnormal_embryogenesis/_devel1.59199634
29MP0005501_abnormal_skin_physiology1.58671425
30MP0005076_abnormal_cell_differentiation1.52945087
31MP0003786_premature_aging1.52346047
32MP0009333_abnormal_splenocyte_physiolog1.50430695
33MP0003984_embryonic_growth_retardation1.49627454
34MP0002088_abnormal_embryonic_growth/wei1.47059303
35* MP0002080_prenatal_lethality1.46851932
36MP0006292_abnormal_olfactory_placode1.45741834
37MP0002019_abnormal_tumor_incidence1.45727414
38* MP0002085_abnormal_embryonic_tissue1.44856575
39MP0005397_hematopoietic_system_phenotyp1.44719980
40MP0001545_abnormal_hematopoietic_system1.44719980
41MP0000703_abnormal_thymus_morphology1.44694891
42MP0002398_abnormal_bone_marrow1.43376797
43MP0002084_abnormal_developmental_patter1.42349194
44MP0000537_abnormal_urethra_morphology1.40980953
45MP0008260_abnormal_autophagy1.39083460
46MP0004197_abnormal_fetal_growth/weight/1.38645612
47MP0002086_abnormal_extraembryonic_tissu1.37695206
48MP0000313_abnormal_cell_death1.37650812
49MP0003121_genomic_imprinting1.36974633
50MP0001873_stomach_inflammation1.34834796
51MP0008877_abnormal_DNA_methylation1.34050060
52MP0002877_abnormal_melanocyte_morpholog1.29685931
53MP0005394_taste/olfaction_phenotype1.28959659
54MP0005499_abnormal_olfactory_system1.28959659
55MP0001727_abnormal_embryo_implantation1.27467941
56MP0002722_abnormal_immune_system1.26268204
57MP0003567_abnormal_fetal_cardiomyocyte1.25305850
58MP0003705_abnormal_hypodermis_morpholog1.24782949
59MP0000685_abnormal_immune_system1.24431635
60MP0009278_abnormal_bone_marrow1.21087218
61MP0000689_abnormal_spleen_morphology1.20489557
62MP0001348_abnormal_lacrimal_gland1.20356826
63MP0004233_abnormal_muscle_weight1.19895044
64MP0008789_abnormal_olfactory_epithelium1.19256077
65MP0000678_abnormal_parathyroid_gland1.16162407
66MP0001293_anophthalmia1.12854939
67MP0005025_abnormal_response_to1.10967448
68MP0000858_altered_metastatic_potential1.10038853
69MP0003806_abnormal_nucleotide_metabolis1.09640122
70MP0005023_abnormal_wound_healing1.07955323
71MP0003315_abnormal_perineum_morphology1.07919502
72MP0009053_abnormal_anal_canal1.07814216
73MP0002653_abnormal_ependyma_morphology1.07427170
74* MP0002429_abnormal_blood_cell1.07192460
75MP0002796_impaired_skin_barrier1.06836945
76MP0003890_abnormal_embryonic-extraembry1.05745929
77MP0002089_abnormal_postnatal_growth/wei1.05651994
78MP0001835_abnormal_antigen_presentation1.05079274
79MP0001800_abnormal_humoral_immune1.04283620
80MP0001915_intracranial_hemorrhage1.03151287
81MP0000716_abnormal_immune_system1.02985788
82MP0002148_abnormal_hypersensitivity_rea1.02157949
83MP0005671_abnormal_response_to1.00812029
84MP0001849_ear_inflammation0.95932580
85MP0002166_altered_tumor_susceptibility0.94536018
86MP0002420_abnormal_adaptive_immunity0.93436672
87MP0003566_abnormal_cell_adhesion0.93054876
88MP0002452_abnormal_antigen_presenting0.93031748
89MP0001819_abnormal_immune_cell0.92348098
90MP0002249_abnormal_larynx_morphology0.91859051
91MP0002405_respiratory_system_inflammati0.91030202
92MP0003718_maternal_effect0.90888871
93MP0000733_abnormal_muscle_development0.90363450
94MP0002210_abnormal_sex_determination0.90347431
95MP0005666_abnormal_adipose_tissue0.89540773
96MP0002006_tumorigenesis0.89317210
97MP0000049_abnormal_middle_ear0.86514321
98MP0000750_abnormal_muscle_regeneration0.86384330
99MP0000428_abnormal_craniofacial_morphol0.86036692
100MP0001919_abnormal_reproductive_system0.85559945
101MP0005464_abnormal_platelet_physiology0.85106901
102MP0001881_abnormal_mammary_gland0.83096001
103MP0003436_decreased_susceptibility_to0.81841452
104MP0003119_abnormal_digestive_system0.80792909
105MP0001853_heart_inflammation0.80401328
106MP0002111_abnormal_tail_morphology0.79626585
107MP0006035_abnormal_mitochondrial_morpho0.78272092
108MP0001145_abnormal_male_reproductive0.78173346
109MP0002723_abnormal_immune_serum0.78042249
110MP0003937_abnormal_limbs/digits/tail_de0.77629026
111MP0005384_cellular_phenotype0.76518623
112MP0003866_abnormal_defecation0.76360791
113MP0002092_abnormal_eye_morphology0.75765171
114MP0001119_abnormal_female_reproductive0.75370094
115MP0005621_abnormal_cell_physiology0.75216646
116MP0000477_abnormal_intestine_morphology0.73737298
117MP0000358_abnormal_cell_content/0.73156875
118MP0009931_abnormal_skin_appearance0.72336859
119MP0003448_altered_tumor_morphology0.71556143
120MP0009672_abnormal_birth_weight0.71111216
121MP0003186_abnormal_redox_activity0.70834264
122MP0005257_abnormal_intraocular_pressure0.70262579
123MP0010155_abnormal_intestine_physiology0.69832846
124MP0003453_abnormal_keratinocyte_physiol0.68222662
125MP0003115_abnormal_respiratory_system0.67497697
126MP0002282_abnormal_trachea_morphology0.67395149
127MP0002925_abnormal_cardiovascular_devel0.66760665
128MP0010234_abnormal_vibrissa_follicle0.66499074
129MP0005000_abnormal_immune_tolerance0.66422446
130MP0001929_abnormal_gametogenesis0.66051764
131MP0000653_abnormal_sex_gland0.65827024
132MP0004947_skin_inflammation0.65521287
133MP0003943_abnormal_hepatobiliary_system0.64526563
134MP0002932_abnormal_joint_morphology0.64002833
135MP0000465_gastrointestinal_hemorrhage0.62810387

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.64605635
2Birth length less than 3rd percentile (HP:0003561)3.61801502
3Colon cancer (HP:0003003)3.45313903
4Abnormality of cells of the erythroid lineage (HP:0012130)3.40920229
5Microvesicular hepatic steatosis (HP:0001414)3.31479584
6Selective tooth agenesis (HP:0001592)3.25037892
7Progressive muscle weakness (HP:0003323)3.22415454
8Agammaglobulinemia (HP:0004432)3.21919204
9Abnormal number of erythroid precursors (HP:0012131)3.20295196
10Patellar aplasia (HP:0006443)3.14288831
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.01926449
12Aplasia/Hypoplasia of the patella (HP:0006498)2.96102058
13Degeneration of anterior horn cells (HP:0002398)2.96007860
14Abnormality of the anterior horn cell (HP:0006802)2.96007860
15Abnormality of reticulocytes (HP:0004312)2.90725686
16Long palpebral fissure (HP:0000637)2.84835336
17Ragged-red muscle fibers (HP:0003200)2.84605560
18Hypertensive crisis (HP:0100735)2.80346422
19Oral leukoplakia (HP:0002745)2.74892827
20Breast hypoplasia (HP:0003187)2.70007392
21Short 4th metacarpal (HP:0010044)2.67909163
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67909163
23Medulloblastoma (HP:0002885)2.66425707
24Insomnia (HP:0100785)2.63854813
25Aplastic anemia (HP:0001915)2.61712651
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54346340
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54346340
28Ependymoma (HP:0002888)2.49435946
29Chromsome breakage (HP:0040012)2.46199899
30Increased nuchal translucency (HP:0010880)2.45331269
31Meckel diverticulum (HP:0002245)2.43487147
32Cellulitis (HP:0100658)2.41285629
33Basal cell carcinoma (HP:0002671)2.38651777
34Overriding aorta (HP:0002623)2.38624131
35Deviation of the thumb (HP:0009603)2.37689828
36Neoplasm of the pancreas (HP:0002894)2.37438805
37Myelodysplasia (HP:0002863)2.37387205
38Pallor (HP:0000980)2.34398120
39Proximal placement of thumb (HP:0009623)2.34034083
4011 pairs of ribs (HP:0000878)2.32544722
41Abnormality of the ileum (HP:0001549)2.32460895
42Thrombocytosis (HP:0001894)2.31884876
43Carpal bone hypoplasia (HP:0001498)2.31386431
44Entropion (HP:0000621)2.30867263
45Agnosia (HP:0010524)2.29050033
46Elfin facies (HP:0004428)2.28262400
47High anterior hairline (HP:0009890)2.27506707
48Abnormality of chromosome stability (HP:0003220)2.24570533
49Atresia of the external auditory canal (HP:0000413)2.23957443
50Increased muscle lipid content (HP:0009058)2.22453529
51Increased IgM level (HP:0003496)2.22397912
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.22187607
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20041959
54Seborrheic dermatitis (HP:0001051)2.18469870
55Increased intramyocellular lipid droplets (HP:0012240)2.17952297
56Rough bone trabeculation (HP:0100670)2.16317733
57Multiple enchondromatosis (HP:0005701)2.16236572
58Ectopic kidney (HP:0000086)2.14345322
59Broad distal phalanx of finger (HP:0009836)2.14171864
60Testicular atrophy (HP:0000029)2.11218234
61Absent thumb (HP:0009777)2.10243289
62Abnormality of the fingertips (HP:0001211)2.09903299
63Macrocytic anemia (HP:0001972)2.09787140
64Aplasia/Hypoplasia of the thymus (HP:0010515)2.09571150
65Chronic obstructive pulmonary disease (HP:0006510)2.09129441
66Obstructive lung disease (HP:0006536)2.09129441
67Duodenal stenosis (HP:0100867)2.09031341
68Small intestinal stenosis (HP:0012848)2.09031341
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.08847645
70Abnormality of the preputium (HP:0100587)2.07730067
71Trismus (HP:0000211)2.07729832
72Truncus arteriosus (HP:0001660)2.04772207
73Deep palmar crease (HP:0006191)2.04281750
74Reticulocytosis (HP:0001923)2.02031075
75Tracheoesophageal fistula (HP:0002575)2.01456788
76Microretrognathia (HP:0000308)2.01136547
77Premature graying of hair (HP:0002216)2.00750495
78Patellar dislocation (HP:0002999)1.99523025
79Cellular immunodeficiency (HP:0005374)1.99438793
80Vertebral compression fractures (HP:0002953)1.99419173
81Lymphoma (HP:0002665)1.98796837
82Recurrent viral infections (HP:0004429)1.96078211
83Thoracic kyphosis (HP:0002942)1.95802838
84Abnormal lung lobation (HP:0002101)1.94610219
85Abnormal number of incisors (HP:0011064)1.93983098
86Volvulus (HP:0002580)1.92966675
87High pitched voice (HP:0001620)1.90489347
88Long eyelashes (HP:0000527)1.89770669
89Myopathic facies (HP:0002058)1.89564126
90Cholecystitis (HP:0001082)1.88994805
91Abnormal gallbladder physiology (HP:0012438)1.88994805
92Hyperthyroidism (HP:0000836)1.88900211
93Rhabdomyosarcoma (HP:0002859)1.88790762
94Abnormality of the calcaneus (HP:0008364)1.87875112
95Optic nerve coloboma (HP:0000588)1.87301066
96Amaurosis fugax (HP:0100576)1.87174729
97Absent radius (HP:0003974)1.87114160
98Cutaneous melanoma (HP:0012056)1.87057246
99IgM deficiency (HP:0002850)1.86328345
100Abnormality of the thoracic spine (HP:0100711)1.86324934
101Increased density of long bones (HP:0006392)1.86203352
102Overlapping toe (HP:0001845)1.84904446
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.84527769
104Abnormal mitochondria in muscle tissue (HP:0008316)1.83815720
105Prominent nose (HP:0000448)1.83793759
106Abnormality of the columella (HP:0009929)1.83059697
107Pointed chin (HP:0000307)1.82745061
108Slender long bone (HP:0003100)1.82737846
109Abnormality of the 4th metacarpal (HP:0010012)1.82199398
110Glossoptosis (HP:0000162)1.81455255
111Bone marrow hypocellularity (HP:0005528)1.80842069
112Panhypogammaglobulinemia (HP:0003139)1.80730799
113Bicuspid aortic valve (HP:0001647)1.80390192
114Premature skin wrinkling (HP:0100678)1.80070481
115Pseudobulbar signs (HP:0002200)1.79680051
116Missing ribs (HP:0000921)1.79122796
117Achilles tendon contracture (HP:0001771)1.78460968
118Combined immunodeficiency (HP:0005387)1.78326095
119Renal duplication (HP:0000075)1.77777858
120Poikiloderma (HP:0001029)1.77255561
121Cerebral palsy (HP:0100021)1.75322661
122Abnormal trabecular bone morphology (HP:0100671)1.75145067
123Cleft eyelid (HP:0000625)1.75040298
124Hyperacusis (HP:0010780)1.74771659
125Skin tags (HP:0010609)1.74106917
126Hepatocellular necrosis (HP:0001404)1.73909944
127Aplasia involving forearm bones (HP:0009822)1.73378643
128Absent forearm bone (HP:0003953)1.73378643
129Mediastinal lymphadenopathy (HP:0100721)1.73102384
130Horseshoe kidney (HP:0000085)1.72771550
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72690461
132Absent epiphyses (HP:0010577)1.72690461
133Cafe-au-lait spot (HP:0000957)1.72650567
134Preauricular skin tag (HP:0000384)1.72531383
135Abnormality of the duodenum (HP:0002246)1.71249488
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70696119
137Increased IgE level (HP:0003212)1.70486806
138Abnormality of the carotid arteries (HP:0005344)1.69893992
139Pancytopenia (HP:0001876)1.69176658
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.68442654
141Squamous cell carcinoma (HP:0002860)1.68060527
142Partial duplication of thumb phalanx (HP:0009944)1.67770717
143Neoplasm of the colon (HP:0100273)1.67121771
144Sloping forehead (HP:0000340)1.66758832
145Recurrent bronchitis (HP:0002837)1.66023224
146Abnormality of T cells (HP:0002843)1.65895630
147Disproportionate tall stature (HP:0001519)1.65771595
148Broad palm (HP:0001169)1.65207862
149T lymphocytopenia (HP:0005403)1.64782380
150Pelvic girdle muscle weakness (HP:0003749)1.64552132
151Abnormality of DNA repair (HP:0003254)1.64550825
152Blepharitis (HP:0000498)1.63921254
153Spina bifida occulta (HP:0003298)1.63791871
154Verrucae (HP:0200043)1.63068985
155Papilloma (HP:0012740)1.63068985
156Severe combined immunodeficiency (HP:0004430)1.62384366
157Gastrointestinal carcinoma (HP:0002672)1.61604241
158Malignant gastrointestinal tract tumors (HP:0006749)1.61604241
159Premature ovarian failure (HP:0008209)1.61547580
160Ankle contracture (HP:0006466)1.61382883
161IgG deficiency (HP:0004315)1.59762884
162Elevated erythrocyte sedimentation rate (HP:0003565)1.58843274
163Duplication of thumb phalanx (HP:0009942)1.58321568
164J-shaped sella turcica (HP:0002680)1.57796763
165Thick lower lip vermilion (HP:0000179)1.56866911
166Meningitis (HP:0001287)1.55219163
167Rib fusion (HP:0000902)1.55198796
168Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.54860598
169Trigonocephaly (HP:0000243)1.54671751
170Granulocytopenia (HP:0001913)1.53601559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.30335948
2BUB13.81031294
3CDC73.74300072
4WEE13.21517845
5SMG13.15312381
6NEK22.76132181
7EIF2AK12.55303760
8EEF2K2.48570336
9SRPK12.29162441
10ACVR1B2.20642809
11MAP3K102.14282006
12ARAF2.11050814
13TESK22.05623147
14RPS6KB21.94130966
15PLK41.91313549
16RPS6KA41.89402145
17MAP4K11.80070108
18TTK1.73968520
19CDK121.72353636
20TGFBR11.72201837
21STK101.71502981
22TSSK61.71033982
23PRPF4B1.66650590
24ICK1.62913653
25PASK1.61026409
26NME21.60849282
27ATR1.60100601
28IRAK31.59501747
29DYRK31.58421803
30AURKB1.58279178
31PAK41.57737177
32PLK11.57232755
33BCKDK1.56088194
34CDK71.52827736
35BRSK21.50201971
36SIK11.49849773
37MKNK11.48726197
38NEK11.47306708
39TESK11.45748672
40VRK11.43514837
41LRRK21.42662565
42MAP3K81.40859617
43SCYL21.39709523
44PKN21.36099451
45CDK41.34687301
46KDR1.32569677
47TLK11.26578650
48EPHA21.24391003
49MAP3K131.21030397
50EIF2AK31.19338372
51CHEK21.13634241
52CHEK11.10042144
53TRIB31.07894727
54STK41.06864846
55BRAF1.05984571
56PIM11.03899104
57MAP2K21.03092144
58PLK31.02705028
59BRSK10.98815447
60NME10.98635871
61TAOK20.97397690
62FLT30.94136826
63CDK60.93387492
64ZAP700.90580445
65AURKA0.90168173
66PIM20.83948212
67JAK30.83113390
68MAPKAPK30.81492596
69STK160.81371866
70MELK0.80230289
71CCNB10.80188886
72BTK0.77709987
73MAP3K110.75751483
74ATM0.75250924
75CDK20.74811070
76ILK0.72728015
77STK30.72079520
78MKNK20.70198014
79MAP2K30.68818947
80CDK190.68453591
81LATS10.67409110
82TYK20.67044802
83TAF10.62410526
84PAK10.62172964
85CHUK0.61473811
86RPS6KL10.59406525
87RPS6KC10.59406525
88BRD40.59028223
89CDK11A0.58468010
90DYRK20.57118190
91SIK20.56603807
92MTOR0.55526913
93MOS0.55503463
94MAPK110.54405750
95CDK140.53934949
96GRK60.53828964
97CSF1R0.53712739
98ALK0.53609390
99LIMK10.50880233
100CDK80.50078244
101TTN0.50066221
102CDK150.49742065
103FGFR40.49113816
104NEK90.48909522
105* CDK10.48608612
106DAPK10.48414448
107CDK90.48347654
108RPS6KA20.47629926
109PAK20.47269795
110MATK0.46065590
111ITK0.45744109
112MAP3K90.45000896
113ZAK0.44782202
114CSNK2A20.44068123
115KIT0.43289886
116RPS6KA10.43252010
117RPS6KA60.42801943
118CSNK2A10.42329543
119ABL20.41845621
120TXK0.41668229
121RPS6KA50.41411144
122RAF10.41407776
123CDK180.41309535
124TEC0.41191490
125DYRK1B0.40816644
126MARK20.39794992
127IRAK40.39537493
128FGFR10.39357920
129HIPK20.38666948
130TYRO30.38628028
131NTRK10.38608629
132KSR20.37962229
133DAPK30.37729840
134ERN10.35905564
135BMX0.35759920
136PTK60.34862087
137AKT20.34114325
138TBK10.31766623
139CLK10.31664193
140IKBKB0.29622838
141MAPKAPK20.29318348
142EIF2AK20.28881028

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62688918
2Mismatch repair_Homo sapiens_hsa034303.77762324
3Spliceosome_Homo sapiens_hsa030403.20182937
4Ribosome_Homo sapiens_hsa030103.02687475
5Base excision repair_Homo sapiens_hsa034103.00627835
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85285006
7Cell cycle_Homo sapiens_hsa041102.79600834
8* RNA transport_Homo sapiens_hsa030132.74711587
9Proteasome_Homo sapiens_hsa030502.62274439
10Homologous recombination_Homo sapiens_hsa034402.59999599
11Nucleotide excision repair_Homo sapiens_hsa034202.53318777
12RNA polymerase_Homo sapiens_hsa030202.40773620
13One carbon pool by folate_Homo sapiens_hsa006702.19346233
14Pyrimidine metabolism_Homo sapiens_hsa002402.01241894
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95048229
16p53 signaling pathway_Homo sapiens_hsa041151.82633103
17Fanconi anemia pathway_Homo sapiens_hsa034601.82177858
18RNA degradation_Homo sapiens_hsa030181.79851929
19Non-homologous end-joining_Homo sapiens_hsa034501.75640292
20mRNA surveillance pathway_Homo sapiens_hsa030151.72766510
21Basal transcription factors_Homo sapiens_hsa030221.52700388
22Antigen processing and presentation_Homo sapiens_hsa046121.40112277
23Epstein-Barr virus infection_Homo sapiens_hsa051691.39608030
24Primary immunodeficiency_Homo sapiens_hsa053401.32795647
25Herpes simplex infection_Homo sapiens_hsa051681.31768431
26Parkinsons disease_Homo sapiens_hsa050121.31632936
27Viral carcinogenesis_Homo sapiens_hsa052031.26458739
28Systemic lupus erythematosus_Homo sapiens_hsa053221.22242681
29HTLV-I infection_Homo sapiens_hsa051661.16091302
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14121281
31Oxidative phosphorylation_Homo sapiens_hsa001901.13308961
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11207493
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05855192
34Fructose and mannose metabolism_Homo sapiens_hsa000511.05229626
35Small cell lung cancer_Homo sapiens_hsa052221.05139221
36* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01654292
37Huntingtons disease_Homo sapiens_hsa050160.97931388
38Carbon metabolism_Homo sapiens_hsa012000.96400413
39Shigellosis_Homo sapiens_hsa051310.94034025
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93343239
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92808592
42Legionellosis_Homo sapiens_hsa051340.91641220
43VEGF signaling pathway_Homo sapiens_hsa043700.91626377
44Measles_Homo sapiens_hsa051620.91486352
45* MicroRNAs in cancer_Homo sapiens_hsa052060.91253575
46Chronic myeloid leukemia_Homo sapiens_hsa052200.91130435
47Purine metabolism_Homo sapiens_hsa002300.89981910
48Colorectal cancer_Homo sapiens_hsa052100.88832203
49Thyroid cancer_Homo sapiens_hsa052160.87291803
50Apoptosis_Homo sapiens_hsa042100.84958962
51Oocyte meiosis_Homo sapiens_hsa041140.84166838
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83293073
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83222773
54Notch signaling pathway_Homo sapiens_hsa043300.80401399
55Viral myocarditis_Homo sapiens_hsa054160.78534346
56Hepatitis B_Homo sapiens_hsa051610.78486227
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77059605
58* NF-kappa B signaling pathway_Homo sapiens_hsa040640.74745680
59TGF-beta signaling pathway_Homo sapiens_hsa043500.71483192
60Leishmaniasis_Homo sapiens_hsa051400.69288711
61Adherens junction_Homo sapiens_hsa045200.68957461
62Hippo signaling pathway_Homo sapiens_hsa043900.68658139
63Galactose metabolism_Homo sapiens_hsa000520.67890771
64Salmonella infection_Homo sapiens_hsa051320.65461457
65Bladder cancer_Homo sapiens_hsa052190.65450322
66Basal cell carcinoma_Homo sapiens_hsa052170.63226391
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62701573
68Hematopoietic cell lineage_Homo sapiens_hsa046400.61948148
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61709854
70T cell receptor signaling pathway_Homo sapiens_hsa046600.60988377
71Acute myeloid leukemia_Homo sapiens_hsa052210.60837072
72Influenza A_Homo sapiens_hsa051640.60793341
73Alzheimers disease_Homo sapiens_hsa050100.60238241
74Pentose phosphate pathway_Homo sapiens_hsa000300.60081288
75Pancreatic cancer_Homo sapiens_hsa052120.59354005
76B cell receptor signaling pathway_Homo sapiens_hsa046620.59141950
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.57958371
78Autoimmune thyroid disease_Homo sapiens_hsa053200.56818551
79Other glycan degradation_Homo sapiens_hsa005110.55533391
80Fatty acid elongation_Homo sapiens_hsa000620.55339204
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54035650
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54005488
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53703568
84Toxoplasmosis_Homo sapiens_hsa051450.53390418
85Selenocompound metabolism_Homo sapiens_hsa004500.53314734
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.53062527
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51893996
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51195524
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50497584
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50059777
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49399694
92Pathways in cancer_Homo sapiens_hsa052000.48922818
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47452908
94Graft-versus-host disease_Homo sapiens_hsa053320.47377833
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46916147
96Proteoglycans in cancer_Homo sapiens_hsa052050.46285054
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43911178
98Non-small cell lung cancer_Homo sapiens_hsa052230.43539415
99mTOR signaling pathway_Homo sapiens_hsa041500.43185169
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.43026857
101Alcoholism_Homo sapiens_hsa050340.42374452
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42072964
103Allograft rejection_Homo sapiens_hsa053300.41535863
104HIF-1 signaling pathway_Homo sapiens_hsa040660.40827539
105Prion diseases_Homo sapiens_hsa050200.40614446
106Biosynthesis of amino acids_Homo sapiens_hsa012300.40426222
107Glutathione metabolism_Homo sapiens_hsa004800.40204847
108N-Glycan biosynthesis_Homo sapiens_hsa005100.40091118
109Endocytosis_Homo sapiens_hsa041440.39212622
110Endometrial cancer_Homo sapiens_hsa052130.39081203
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37982497
112Prostate cancer_Homo sapiens_hsa052150.37924881
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.37906705
114TNF signaling pathway_Homo sapiens_hsa046680.36494559
115Sulfur relay system_Homo sapiens_hsa041220.36348529
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35526735
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35383571
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.35003764
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.34563623
120Hedgehog signaling pathway_Homo sapiens_hsa043400.32505933
121Vibrio cholerae infection_Homo sapiens_hsa051100.32467145
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.31321378
123Osteoclast differentiation_Homo sapiens_hsa043800.30808833
124FoxO signaling pathway_Homo sapiens_hsa040680.29352395
125Folate biosynthesis_Homo sapiens_hsa007900.28276083
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.27507729

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