UBE2J1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)4.77616106
2COPI coating of Golgi vesicle (GO:0048205)4.62882400
3Golgi transport vesicle coating (GO:0048200)4.62882400
4regulation of B cell receptor signaling pathway (GO:0050855)4.44422116
5positive regulation by symbiont of host defense response (GO:0052509)4.23082524
6modulation by symbiont of host defense response (GO:0052031)4.23082524
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.23082524
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.23082524
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.23082524
10modulation by symbiont of host immune response (GO:0052553)4.23082524
11neutrophil activation involved in immune response (GO:0002283)4.18700085
12immunoglobulin mediated immune response (GO:0016064)4.03208161
13synaptic vesicle maturation (GO:0016188)4.03038051
14response to peptidoglycan (GO:0032494)3.99971128
15acrosome assembly (GO:0001675)3.92775385
16sperm motility (GO:0030317)3.81800487
17germinal center formation (GO:0002467)3.81191406
18regulation of ARF protein signal transduction (GO:0032012)3.72260590
19negative regulation of inclusion body assembly (GO:0090084)3.71723142
20acrosome reaction (GO:0007340)3.70299949
21cellular extravasation (GO:0045123)3.64839823
22macrophage activation involved in immune response (GO:0002281)3.64555457
23B cell homeostasis (GO:0001782)3.58176130
24detection of other organism (GO:0098543)3.43205923
25regulation of B cell differentiation (GO:0045577)3.41625386
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37987608
27B cell mediated immunity (GO:0019724)3.37953299
28NIK/NF-kappaB signaling (GO:0038061)3.34323483
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33582244
30activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.32188186
31regulation of gamma-delta T cell activation (GO:0046643)3.27166289
32detection of bacterium (GO:0016045)3.26951019
33B cell proliferation (GO:0042100)3.26130906
34response to host immune response (GO:0052572)3.24735205
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.24735205
36response to muramyl dipeptide (GO:0032495)3.24144775
37retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20833276
38regulation of T-helper 1 cell differentiation (GO:0045625)3.18796744
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18527945
40negative regulation of T-helper cell differentiation (GO:0045623)3.18527945
41sexual reproduction (GO:0019953)3.18050593
42fusion of sperm to egg plasma membrane (GO:0007342)3.18045348
43sodium ion export (GO:0071436)3.16989334
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16800769
45negative regulation of erythrocyte differentiation (GO:0045647)3.14768281
46interferon-gamma-mediated signaling pathway (GO:0060333)3.13074982
47regulation of synaptic vesicle exocytosis (GO:2000300)3.12884832
48T cell migration (GO:0072678)3.12666747
49positive regulation of nuclease activity (GO:0032075)3.12609479
50negative regulation of cell killing (GO:0031342)3.11771456
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11771456
52response to host (GO:0075136)3.05838255
53response to host defenses (GO:0052200)3.05838255
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05838255
55negative regulation of interleukin-12 production (GO:0032695)3.05013569
56regulation of B cell proliferation (GO:0030888)3.04887535
57positive regulation of interferon-alpha production (GO:0032727)3.03592381
58vesicle coating (GO:0006901)3.03101139
59type I interferon signaling pathway (GO:0060337)3.00447336
60cellular response to type I interferon (GO:0071357)3.00447336
61defense response to protozoan (GO:0042832)2.99869611
62calcium ion-dependent exocytosis (GO:0017156)2.98666315
63regulation of germinal center formation (GO:0002634)2.97598429
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97262308
65regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96884141
66positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.95718370
67lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95052717
68response to type I interferon (GO:0034340)2.94880050
69positive regulation of B cell activation (GO:0050871)2.93284193
70regulation of interferon-alpha production (GO:0032647)2.92916774
71positive regulation of B cell proliferation (GO:0030890)2.92181933
72neutrophil activation (GO:0042119)2.91259862
73endoplasmic reticulum unfolded protein response (GO:0030968)2.90000910
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88618502
75detection of external biotic stimulus (GO:0098581)2.88156750
76histamine secretion (GO:0001821)2.87461350
77myeloid cell activation involved in immune response (GO:0002275)2.87376341
78synaptic vesicle exocytosis (GO:0016079)2.86932103
79activation of protein kinase A activity (GO:0034199)2.85275582
80cellular response to unfolded protein (GO:0034620)2.84900277
81cell wall macromolecule metabolic process (GO:0044036)2.84218899
82cell wall macromolecule catabolic process (GO:0016998)2.84218899
83locomotory exploration behavior (GO:0035641)2.83842590
84protein localization to endosome (GO:0036010)2.83409975
85response to protozoan (GO:0001562)2.81481717
86protein retention in ER lumen (GO:0006621)2.79663367
87regulation of nuclease activity (GO:0032069)2.78843940
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76969183
89granulocyte activation (GO:0036230)2.75328012
90positive regulation of granulocyte differentiation (GO:0030854)2.75205470
91positive thymic T cell selection (GO:0045059)2.74746983
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74611161
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74611161
94detection of molecule of bacterial origin (GO:0032490)2.73968537
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73826449
96negative regulation of fatty acid transport (GO:2000192)2.72502193
97mature B cell differentiation (GO:0002335)2.72307415
98glutamate secretion (GO:0014047)2.72202099
99antigen processing and presentation of endogenous antigen (GO:0019883)2.71701880
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.71092054
101regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70542427
102regulation of B cell activation (GO:0050864)2.69087702
103regulation of antigen processing and presentation (GO:0002577)2.68915253
104lymphocyte homeostasis (GO:0002260)2.68701864
105ER-nucleus signaling pathway (GO:0006984)2.67224262
106regulation of synaptic vesicle transport (GO:1902803)2.67011369
107regulation of T-helper 2 cell differentiation (GO:0045628)2.66957563
108regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66809966
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.65974324
110protein targeting to Golgi (GO:0000042)2.65938238
111regulation of mast cell degranulation (GO:0043304)2.64404755
112negative thymic T cell selection (GO:0045060)2.63936612
113myeloid dendritic cell activation (GO:0001773)2.63102955
114cellular potassium ion homeostasis (GO:0030007)2.62985859
115regulation of clathrin-mediated endocytosis (GO:2000369)2.62814541
116positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.62622209
117positive regulation of protein homooligomerization (GO:0032464)2.61710460
118cellular response to topologically incorrect protein (GO:0035967)2.61267406
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.60691984
120positive regulation of Rap GTPase activity (GO:0032854)2.59939778
121retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59404921
122establishment of protein localization to Golgi (GO:0072600)2.59336965
123regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.58968144
124T cell homeostasis (GO:0043029)2.58820853
125JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.58735447
126mononuclear cell proliferation (GO:0032943)2.58548317
127plasma membrane fusion (GO:0045026)2.58398188
128macrophage activation (GO:0042116)2.57914690
129respiratory burst (GO:0045730)2.57343937
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56457052
131T-helper 1 type immune response (GO:0042088)2.55872750
132regulation of leukocyte degranulation (GO:0043300)2.55425035
133lymphocyte proliferation (GO:0046651)2.55155814
134mature B cell differentiation involved in immune response (GO:0002313)2.54590474
135antigen receptor-mediated signaling pathway (GO:0050851)2.54226019
136detection of biotic stimulus (GO:0009595)2.53670189
137leukocyte aggregation (GO:0070486)2.51950198
138regulation of alpha-beta T cell proliferation (GO:0046640)2.51163065
139CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.50724805
140response to endoplasmic reticulum stress (GO:0034976)2.49673846
141COPII vesicle coating (GO:0048208)2.49215902
142clathrin coat assembly (GO:0048268)2.48529200
143synaptic vesicle docking involved in exocytosis (GO:0016081)2.47914860
144negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45549147
145sperm-egg recognition (GO:0035036)2.44061086
146positive regulation of vesicle fusion (GO:0031340)2.39836137
147reproduction (GO:0000003)2.39702615
148regulation of glucose import in response to insulin stimulus (GO:2001273)2.39612629
149cerebellar Purkinje cell layer development (GO:0021680)2.39486398
150positive regulation of histone deacetylation (GO:0031065)2.38676395
151neurotransmitter secretion (GO:0007269)2.37401737
152vesicle transport along microtubule (GO:0047496)2.36856129
153positive regulation of B cell differentiation (GO:0045579)2.36084659
154cell-cell recognition (GO:0009988)2.35860301
155macroautophagy (GO:0016236)2.34179805
156regulation of early endosome to late endosome transport (GO:2000641)2.33028890
157regulation of NFAT protein import into nucleus (GO:0051532)2.32558026
158positive regulation of gamma-delta T cell activation (GO:0046645)2.32084922
159endoplasmic reticulum organization (GO:0007029)2.30402573
160lipid translocation (GO:0034204)2.29671078
161phospholipid translocation (GO:0045332)2.29671078
162response to unfolded protein (GO:0006986)2.29595750
163regulation of defense response to virus by virus (GO:0050690)2.27160854
164proline transport (GO:0015824)2.26224821
165axon cargo transport (GO:0008088)2.25344814
166regulation of interleukin-12 biosynthetic process (GO:0045075)2.25288041
167insulin secretion (GO:0030073)2.24831448
168Golgi organization (GO:0007030)2.22996268
169nerve growth factor signaling pathway (GO:0038180)2.22729074
170growth hormone receptor signaling pathway (GO:0060396)2.22336149
171protein targeting to plasma membrane (GO:0072661)2.22162256
172positive regulation of nitric-oxide synthase activity (GO:0051000)2.22102534
173regulation of inclusion body assembly (GO:0090083)2.20531316
174localization within membrane (GO:0051668)2.20526184
175multicellular organism reproduction (GO:0032504)2.17317478
176regulation of gamma-delta T cell differentiation (GO:0045586)2.14410316
177* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.13827481
178regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.13627209
179response to topologically incorrect protein (GO:0035966)2.12943221
180regulation of ARF GTPase activity (GO:0032312)2.09042155
181exocrine pancreas development (GO:0031017)2.08816853
182positive regulation of macrophage cytokine production (GO:0060907)2.08010458
183positive regulation of glycolytic process (GO:0045821)2.07211299
184natural killer cell differentiation (GO:0001779)2.05555516
185negative regulation of cell size (GO:0045792)2.04642393
186regulation of interferon-beta biosynthetic process (GO:0045357)2.04057749
187positive regulation of fibroblast migration (GO:0010763)2.03602975
188protein maturation by protein folding (GO:0022417)2.02942798
189antigen processing and presentation via MHC class Ib (GO:0002475)2.02307216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.51650512
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.94394779
3SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80268272
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77870913
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71383641
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65517956
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.59837914
8SPI1_23547873_ChIP-Seq_NB4_Human2.50749500
9SCL_19346495_ChIP-Seq_HPC-7_Human2.44546272
10VDR_21846776_ChIP-Seq_THP-1_Human2.23240271
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21107236
12* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18292779
13EZH2_22144423_ChIP-Seq_EOC_Human2.01072544
14RUNX_20019798_ChIP-Seq_JUKART_Human1.95316779
15EGR1_19374776_ChIP-ChIP_THP-1_Human1.88051469
16IRF8_27001747_Chip-Seq_BMDM_Mouse1.79312553
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79088149
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77559485
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67051105
20GATA2_22383799_ChIP-Seq_G1ME_Mouse1.65457061
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64583240
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61280220
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56972292
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55026349
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54711811
26TCF7_22412390_ChIP-Seq_EML_Mouse1.53896119
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52817642
28KDM2B_26808549_Chip-Seq_DND41_Human1.51785047
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48782034
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45985977
31GATA1_22025678_ChIP-Seq_K562_Human1.45846063
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45575363
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.45442007
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44470427
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43520458
36MYB_26560356_Chip-Seq_TH2_Human1.40961196
37MYC_22102868_ChIP-Seq_BL_Human1.40642843
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40381408
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39572996
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38764465
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38309718
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38168266
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.37650455
44DROSHA_22980978_ChIP-Seq_HELA_Human1.32957231
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31562084
46SPI1_23127762_ChIP-Seq_K562_Human1.30171909
47TFEB_21752829_ChIP-Seq_HELA_Human1.27621406
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27567139
49* GATA3_27048872_Chip-Seq_THYMUS_Human1.26880651
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24264055
51MAF_26560356_Chip-Seq_TH1_Human1.24178453
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23525126
53CIITA_25753668_ChIP-Seq_RAJI_Human1.23448093
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23068471
55VDR_24787735_ChIP-Seq_THP-1_Human1.22423824
56* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21843367
57GATA3_26560356_Chip-Seq_TH2_Human1.21522984
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20856769
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20286934
60KDM2B_26808549_Chip-Seq_K562_Human1.20214072
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18721236
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.18671438
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18549201
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18255043
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17466556
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16416508
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.14840240
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14654086
69MAF_26560356_Chip-Seq_TH2_Human1.14550185
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13748829
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12457227
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11607494
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11202813
74LXR_22292898_ChIP-Seq_THP-1_Human1.10790165
75REST_21632747_ChIP-Seq_MESCs_Mouse1.10754030
76CLOCK_20551151_ChIP-Seq_293T_Human1.10105262
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09877260
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09178916
79FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08604809
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07425862
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.07283428
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07188249
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04699499
84* UTX_26944678_Chip-Seq_JUKART_Human1.04371729
85ZNF274_21170338_ChIP-Seq_K562_Hela1.04089729
86VDR_24763502_ChIP-Seq_THP-1_Human1.03836684
87GATA1_19941826_ChIP-Seq_K562_Human1.03463124
88* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01937161
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01852397
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01640470
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00510110
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00478289
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00400844
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00220400
95* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00134615
96* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99525205
97ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99325735
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.99267958
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97686361
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95986157
101KDM2B_26808549_Chip-Seq_JURKAT_Human0.95701700
102* MYB_26560356_Chip-Seq_TH1_Human0.95093738
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94344239
104GATA2_19941826_ChIP-Seq_K562_Human0.93280263
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92338289
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92287599
107* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92282942
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92073512
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91680030
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91071995
111ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90623599
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90039426
113* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89472594
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88704820
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.88682022
116NCOR1_26117541_ChIP-Seq_K562_Human0.88514058
117EGR1_19032775_ChIP-ChIP_M12_Human0.87935436
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87100627
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.86662213
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.86662213
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86247620
122CJUN_26792858_Chip-Seq_BT549_Human0.85726892
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85509051
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85170318
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83813775
126ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83802489
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83626353
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83622262
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83586777
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.83512409
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.83461102
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83156658
133CBP_20019798_ChIP-Seq_JUKART_Human0.82623501
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82623501
135FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82609333
136PU_27001747_Chip-Seq_BMDM_Mouse0.82290220
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82160072
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.81379964
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81265792
140LXR_22158963_ChIP-Seq_LIVER_Mouse0.81219946
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79862106
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79614271
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77910060
144SMRT_27268052_Chip-Seq_Bcells_Human0.76916641
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76642988
146CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75021111
147RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73206609
148KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72007535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.80685334
2MP0003300_gastrointestinal_ulcer3.44133092
3MP0003724_increased_susceptibility_to2.92356401
4MP0003303_peritoneal_inflammation2.83695086
5MP0002909_abnormal_adrenal_gland2.68625239
6MP0010234_abnormal_vibrissa_follicle2.63083934
7MP0000013_abnormal_adipose_tissue2.61659757
8MP0004859_abnormal_synaptic_plasticity2.48924433
9MP0009780_abnormal_chondrocyte_physiolo2.43960117
10MP0003763_abnormal_thymus_physiology2.32896953
11MP0000465_gastrointestinal_hemorrhage2.15257847
12MP0002877_abnormal_melanocyte_morpholog1.98299137
13MP0003436_decreased_susceptibility_to1.91719008
14MP0003183_abnormal_peptide_metabolism1.89422764
15MP0004510_myositis1.88354123
16MP0002009_preneoplasia1.87928224
17MP0008961_abnormal_basal_metabolism1.81914272
18MP0002138_abnormal_hepatobiliary_system1.77768529
19MP0003705_abnormal_hypodermis_morpholog1.74758853
20MP0003172_abnormal_lysosome_physiology1.70376938
21MP0003045_fibrosis1.69624641
22MP0000569_abnormal_digit_pigmentation1.69411155
23MP0000689_abnormal_spleen_morphology1.69018395
24MP0001835_abnormal_antigen_presentation1.68222532
25MP0002396_abnormal_hematopoietic_system1.65579621
26MP0004808_abnormal_hematopoietic_stem1.63837323
27MP0008438_abnormal_cutaneous_collagen1.63673970
28MP0002429_abnormal_blood_cell1.59176935
29MP0002722_abnormal_immune_system1.58526669
30MP0001790_abnormal_immune_system1.56434593
31MP0005387_immune_system_phenotype1.56434593
32MP0005000_abnormal_immune_tolerance1.54222368
33MP0008057_abnormal_DNA_replication1.52938874
34MP0002693_abnormal_pancreas_physiology1.51731726
35MP0004270_analgesia1.51459071
36MP0001533_abnormal_skeleton_physiology1.49630606
37MP0003828_pulmonary_edema1.48155974
38MP0005451_abnormal_body_composition1.47932906
39MP0003191_abnormal_cellular_cholesterol1.47593299
40MP0000604_amyloidosis1.46165497
41MP0000685_abnormal_immune_system1.44466101
42MP0000003_abnormal_adipose_tissue1.43578583
43MP0003329_amyloid_beta_deposits1.41085854
44MP0005310_abnormal_salivary_gland1.39767431
45MP0004947_skin_inflammation1.39736297
46MP0003075_altered_response_to1.35517464
47MP0003635_abnormal_synaptic_transmissio1.34136038
48MP0002166_altered_tumor_susceptibility1.33835705
49MP0001968_abnormal_touch/_nociception1.31448087
50MP0004858_abnormal_nervous_system1.31259836
51MP0009333_abnormal_splenocyte_physiolog1.30546581
52MP0001800_abnormal_humoral_immune1.30385949
53MP0005058_abnormal_lysosome_morphology1.29405140
54MP0005397_hematopoietic_system_phenotyp1.28948632
55MP0001545_abnormal_hematopoietic_system1.28948632
56MP0005671_abnormal_response_to1.28945929
57MP0001944_abnormal_pancreas_morphology1.28197596
58MP0002933_joint_inflammation1.27423386
59MP0002896_abnormal_bone_mineralization1.26878449
60MP0000703_abnormal_thymus_morphology1.25259486
61MP0003656_abnormal_erythrocyte_physiolo1.24998389
62MP0008004_abnormal_stomach_pH1.24740235
63MP0002723_abnormal_immune_serum1.24267258
64MP0002452_abnormal_antigen_presenting1.24187584
65MP0009278_abnormal_bone_marrow1.23873251
66MP0005076_abnormal_cell_differentiation1.23279359
67MP0001873_stomach_inflammation1.21899889
68MP0009840_abnormal_foam_cell1.21576725
69MP0006054_spinal_hemorrhage1.19717152
70MP0002928_abnormal_bile_duct1.18093211
71MP0002419_abnormal_innate_immunity1.18079305
72MP0004130_abnormal_muscle_cell1.17852488
73MP0001853_heart_inflammation1.17308909
74MP0008469_abnormal_protein_level1.16796478
75MP0002998_abnormal_bone_remodeling1.16795332
76MP0003279_aneurysm1.15766633
77MP0001299_abnormal_eye_distance/1.14762641
78MP0005464_abnormal_platelet_physiology1.13478008
79MP0003091_abnormal_cell_migration1.13429632
80MP0002420_abnormal_adaptive_immunity1.12794945
81MP0001819_abnormal_immune_cell1.11599968
82MP0001845_abnormal_inflammatory_respons1.11559404
83MP0008260_abnormal_autophagy1.08202661
84MP0000858_altered_metastatic_potential1.07920091
85MP0001348_abnormal_lacrimal_gland1.07802804
86MP0003866_abnormal_defecation1.07071196
87MP0002735_abnormal_chemical_nociception1.05139077
88MP0004811_abnormal_neuron_physiology1.02674690
89MP0010352_gastrointestinal_tract_polyps1.01306986
90MP0003868_abnormal_feces_composition1.00839246
91MP0002405_respiratory_system_inflammati0.98488004
92MP0006082_CNS_inflammation0.98348950
93MP0002090_abnormal_vision0.98055105
94MP0008569_lethality_at_weaning0.97248705
95MP0002006_tumorigenesis0.97221220
96MP0003633_abnormal_nervous_system0.96242989
97MP0005535_abnormal_body_temperature0.94838478
98MP0001879_abnormal_lymphatic_vessel0.94363915
99MP0003252_abnormal_bile_duct0.94336605
100MP0002734_abnormal_mechanical_nocicepti0.93437971
101MP0002078_abnormal_glucose_homeostasis0.93351597
102MP0009046_muscle_twitch0.92128770
103MP0002736_abnormal_nociception_after0.91734080
104MP0000249_abnormal_blood_vessel0.90660733
105MP0005166_decreased_susceptibility_to0.90557729
106MP0001663_abnormal_digestive_system0.90295361
107MP0000015_abnormal_ear_pigmentation0.90160261
108MP0002398_abnormal_bone_marrow0.89762333
109MP0001851_eye_inflammation0.89141355
110MP0002139_abnormal_hepatobiliary_system0.88906543
111MP0003879_abnormal_hair_cell0.88815291
112MP0010386_abnormal_urinary_bladder0.88354621
113MP0002089_abnormal_postnatal_growth/wei0.87576421
114MP0005375_adipose_tissue_phenotype0.87528161
115MP0005083_abnormal_biliary_tract0.87477310
116MP0010155_abnormal_intestine_physiology0.86954441
117MP0002733_abnormal_thermal_nociception0.86398428
118MP0000343_altered_response_to0.86367064
119MP0005275_abnormal_skin_tensile0.85134774
120MP0005025_abnormal_response_to0.85003701
121MP0003566_abnormal_cell_adhesion0.84924537
122MP0009785_altered_susceptibility_to0.84473423
123MP0000490_abnormal_crypts_of0.84407095
124MP0000716_abnormal_immune_system0.84373673
125MP0003448_altered_tumor_morphology0.83603523
126MP0003795_abnormal_bone_structure0.82242591
127MP0005220_abnormal_exocrine_pancreas0.81323591
128MP0001970_abnormal_pain_threshold0.80650117
129MP0002063_abnormal_learning/memory/cond0.80133672
130MP0002064_seizures0.79160583
131MP0009764_decreased_sensitivity_to0.78938746
132MP0001765_abnormal_ion_homeostasis0.77825592
133MP0005503_abnormal_tendon_morphology0.77672632
134MP0003698_abnormal_male_reproductive0.76614085
135MP0002148_abnormal_hypersensitivity_rea0.74956937
136MP0001501_abnormal_sleep_pattern0.74933286
137MP0009763_increased_sensitivity_to0.74780505
138MP0004233_abnormal_muscle_weight0.74595352
139MP0004883_abnormal_blood_vessel0.74348541
140MP0002019_abnormal_tumor_incidence0.69885887
141MP0005165_increased_susceptibility_to0.69427868
142MP0005164_abnormal_response_to0.67415160
143MP0002132_abnormal_respiratory_system0.65596978
144MP0005621_abnormal_cell_physiology0.63191706
145MP0000609_abnormal_liver_physiology0.61059427
146MP0005390_skeleton_phenotype0.60948430
147MP0002136_abnormal_kidney_physiology0.59440928
148MP0005381_digestive/alimentary_phenotyp0.56764713

Predicted human phenotypes

RankGene SetZ-score
1Meningitis (HP:0001287)4.08479218
2Abnormal delayed hypersensitivity skin test (HP:0002963)3.70210430
3Gastrointestinal stroma tumor (HP:0100723)3.67403472
4Abnormality of B cell number (HP:0010975)3.66951325
5Abnormality of macrophages (HP:0004311)3.66863048
6B lymphocytopenia (HP:0010976)3.62447466
7Panhypogammaglobulinemia (HP:0003139)3.51422713
8Recurrent fungal infections (HP:0002841)3.50528859
9Spontaneous hematomas (HP:0007420)3.48173463
10Mediastinal lymphadenopathy (HP:0100721)3.46843954
11Vasculitis (HP:0002633)3.41330324
12Recurrent cutaneous fungal infections (HP:0011370)3.34299557
13Chronic mucocutaneous candidiasis (HP:0002728)3.34299557
14Prolonged bleeding time (HP:0003010)3.21369877
15Chronic diarrhea (HP:0002028)3.15911664
16Papilledema (HP:0001085)3.09761632
17Petechiae (HP:0000967)3.02198928
18Nasal polyposis (HP:0100582)2.99205647
19Hypercortisolism (HP:0001578)2.93642583
20Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.92435028
21Epistaxis (HP:0000421)2.89049851
22Obstructive lung disease (HP:0006536)2.88863374
23Chronic obstructive pulmonary disease (HP:0006510)2.88863374
24Recurrent skin infections (HP:0001581)2.84892951
25Autoimmune hemolytic anemia (HP:0001890)2.82934167
26Gingival bleeding (HP:0000225)2.82821999
27Abnormality of T cell number (HP:0011839)2.80639297
28T lymphocytopenia (HP:0005403)2.79977349
29Sepsis (HP:0100806)2.78611199
30Myositis (HP:0100614)2.76038830
31Autoimmune thrombocytopenia (HP:0001973)2.73303241
32Abnormality of T cell physiology (HP:0011840)2.69220251
33Elevated erythrocyte sedimentation rate (HP:0003565)2.67439813
34Recurrent pneumonia (HP:0006532)2.63410592
35Increased IgE level (HP:0003212)2.63176273
36Abnormality of T cells (HP:0002843)2.62678302
37Encephalitis (HP:0002383)2.62428152
38Pulmonary infiltrates (HP:0002113)2.61626911
39Cerebral aneurysm (HP:0004944)2.61449938
40Urticaria (HP:0001025)2.58464058
41Aortic aneurysm (HP:0004942)2.58023835
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.56855330
43Recurrent gram-negative bacterial infections (HP:0005420)2.56364287
44Lymphopenia (HP:0001888)2.54825056
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.54673061
46Absent/shortened dynein arms (HP:0200106)2.54673061
47Gastrointestinal infarctions (HP:0005244)2.53192632
48Supranuclear gaze palsy (HP:0000605)2.51706515
49Orchitis (HP:0100796)2.51487442
50Abnormality of glycolipid metabolism (HP:0010969)2.51267629
51Abnormality of liposaccharide metabolism (HP:0010968)2.51267629
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.51267629
53Granulocytopenia (HP:0001913)2.51051097
54Mitral stenosis (HP:0001718)2.50215017
55Abnormality of the prostate (HP:0008775)2.50119330
56Recurrent lower respiratory tract infections (HP:0002783)2.48951399
57Visual hallucinations (HP:0002367)2.45436726
58Abnormality of the nasal mucosa (HP:0000433)2.44941879
59Action tremor (HP:0002345)2.42208870
60Purpura (HP:0000979)2.42137231
61Emphysema (HP:0002097)2.42095032
62Optic neuritis (HP:0100653)2.41585427
63Retrobulbar optic neuritis (HP:0100654)2.41585427
64Dilatation of the ascending aorta (HP:0005111)2.40199621
65Severe combined immunodeficiency (HP:0004430)2.39948710
66Leukocytosis (HP:0001974)2.37668262
67Recurrent bronchitis (HP:0002837)2.36308457
68Macroorchidism (HP:0000053)2.36246961
69Chest pain (HP:0100749)2.35685248
70Striae distensae (HP:0001065)2.33488457
71Cellulitis (HP:0100658)2.30354367
72Abnormal platelet volume (HP:0011876)2.29981412
73Long toe (HP:0010511)2.28530499
74Mucopolysacchariduria (HP:0008155)2.28433283
75Urinary glycosaminoglycan excretion (HP:0003541)2.28433283
76Restrictive lung disease (HP:0002091)2.27072894
77Abnormality of the vasculature of the conjunctiva (HP:0008054)2.26388206
78Agitation (HP:0000713)2.25185681
79Stomatitis (HP:0010280)2.25135679
80Eczematoid dermatitis (HP:0000976)2.24670888
81Eosinophilia (HP:0001880)2.23959635
82IgA deficiency (HP:0002720)2.22771873
83Agammaglobulinemia (HP:0004432)2.22690497
84Skin rash (HP:0000988)2.21394773
85Hypergammaglobulinemia (HP:0010702)2.20436762
86Thrombocytosis (HP:0001894)2.20014164
87Hand muscle atrophy (HP:0009130)2.19399245
88Vacuolated lymphocytes (HP:0001922)2.18643072
89Combined immunodeficiency (HP:0005387)2.17825766
90Gingivitis (HP:0000230)2.17608925
91Conjunctival telangiectasia (HP:0000524)2.16715085
92Hypoplasia of the thymus (HP:0000778)2.15364600
93Mucosal telangiectasiae (HP:0100579)2.13839015
94Dysostosis multiplex (HP:0000943)2.13171902
95Bronchitis (HP:0012387)2.11226854
96Interstitial pulmonary disease (HP:0006530)2.10604485
97Increased cerebral lipofuscin (HP:0011813)2.09754972
98Infertility (HP:0000789)2.09524316
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09113228
100Hemoptysis (HP:0002105)2.08625509
101Abnormality of the peritoneum (HP:0002585)2.06930196
102Increased IgM level (HP:0003496)2.06246755
103Protrusio acetabuli (HP:0003179)2.04120675
104Disinhibition (HP:0000734)2.04003788
105Thyroiditis (HP:0100646)2.02849544
106Colitis (HP:0002583)2.02837511
107Menstrual irregularities (HP:0000858)2.01872608
108Mitral valve prolapse (HP:0001634)2.00614826
109Impaired platelet aggregation (HP:0003540)2.00104641
110Abnormal platelet function (HP:0011869)2.00104641
111Abnormality of polysaccharide metabolism (HP:0011012)1.99292558
112Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99292558
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99292558
114Depression (HP:0000716)1.99210736
115Tetraparesis (HP:0002273)1.98580774
116Increased mean platelet volume (HP:0011877)1.98483099
117Mutism (HP:0002300)1.97917176
118Chronic otitis media (HP:0000389)1.97904692
119Spondylolisthesis (HP:0003302)1.97802435
120Fatigue (HP:0012378)1.97770333
121Lymphoma (HP:0002665)1.96627760
122Upper limb amyotrophy (HP:0009129)1.96099970
123Distal upper limb amyotrophy (HP:0007149)1.96099970
124Skin ulcer (HP:0200042)1.95772540
125Arterial tortuosity (HP:0005116)1.95190057
126Verrucae (HP:0200043)1.94003674
127Papilloma (HP:0012740)1.94003674
128Recurrent viral infections (HP:0004429)1.93529101
129Abnormality of eosinophils (HP:0001879)1.93172478
130Lymphedema (HP:0001004)1.92449293
131Recurrent bacterial skin infections (HP:0005406)1.91131181
132Thoracolumbar scoliosis (HP:0002944)1.90260095
133Increased CSF protein (HP:0002922)1.89424408
134Vascular tortuosity (HP:0004948)1.89176214
135Recurrent sinusitis (HP:0011108)1.83876445
136Focal seizures (HP:0007359)1.79592230
137Retinal atrophy (HP:0001105)1.77750748
138Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77155540
139Recurrent abscess formation (HP:0002722)1.76806904
140Truncal ataxia (HP:0002078)1.76745582
141Rhinitis (HP:0012384)1.76677173
142Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74801972
143Cervical subluxation (HP:0003308)1.74282320
144Genu recurvatum (HP:0002816)1.73736187
145Chronic bronchitis (HP:0004469)1.73604448
146Postural instability (HP:0002172)1.73529915
147Progressive cerebellar ataxia (HP:0002073)1.71700886
148Protuberant abdomen (HP:0001538)1.71064721
149Thin bony cortex (HP:0002753)1.69855409
150Myocardial infarction (HP:0001658)1.68674056
151Heterotopia (HP:0002282)1.67994369
152Recurrent otitis media (HP:0000403)1.67593298
153Increased density of long bones (HP:0006392)1.66718107
154Aortic dissection (HP:0002647)1.66599456
155Vertebral compression fractures (HP:0002953)1.66417688
156Pheochromocytoma (HP:0002666)1.65085166
157Aneurysm (HP:0002617)1.64210898
158Hematochezia (HP:0002573)1.64064848
159Absence seizures (HP:0002121)1.62392988
160Osteomyelitis (HP:0002754)1.62040278
161Severe short stature (HP:0003510)1.61083612
162Increased neuronal autofluorescent lipopigment (HP:0002074)1.60929660
163Central scotoma (HP:0000603)1.60894198
164Neoplasm of the heart (HP:0100544)1.60077114
165Inflammation of the large intestine (HP:0002037)1.59594700
166Arterial thrombosis (HP:0004420)1.59575195
167Ovoid vertebral bodies (HP:0003300)1.59536242
168Amyotrophic lateral sclerosis (HP:0007354)1.58814387
169Gastrointestinal inflammation (HP:0004386)1.58798674
170Viral hepatitis (HP:0006562)1.58512005
171Neuronal loss in central nervous system (HP:0002529)1.58364189
172Peritonitis (HP:0002586)1.55813317
173Growth hormone excess (HP:0000845)1.55534714
174Genetic anticipation (HP:0003743)1.55491692
175Joint stiffness (HP:0001387)1.55000990
176Enlarged penis (HP:0000040)1.54789618
177Asymmetric septal hypertrophy (HP:0001670)1.54740202
178Spinal canal stenosis (HP:0003416)1.54735291
179Resting tremor (HP:0002322)1.54291545
180Ankle clonus (HP:0011448)1.53985873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.42331069
2PRPF4B3.05711434
3IRAK42.78266510
4TESK12.74355563
5ERN12.71396864
6PRKD32.66790207
7MAP3K102.30838367
8EIF2AK32.16204701
9SCYL22.11337755
10FRK2.08361121
11RIPK42.06992156
12BMPR22.05870507
13IKBKE2.03491173
14CAMKK12.03297386
15BLK1.96403127
16BTK1.94387177
17PDK31.94219019
18PDK41.94219019
19PKN21.90221491
20MAP3K91.89139981
21MAP2K31.84387688
22MAP3K21.81533323
23JAK11.79340663
24KSR21.79281055
25KIT1.75546965
26RET1.73042270
27RIPK11.72417932
28CSF1R1.71206282
29MINK11.66086658
30PIK3CG1.64390714
31MAP4K11.64142749
32CAMKK21.55471649
33SIK31.50126694
34NTRK31.49102504
35TAOK11.46007665
36FGFR31.45280277
37TBK11.44020715
38CSK1.40987150
39EEF2K1.40732700
40LYN1.40060520
41IKBKB1.39584330
42IRAK31.34583641
43PRKCH1.34529201
44ITK1.30373427
45ZAP701.29979949
46NTRK11.29596533
47TAOK31.27435518
48PAK61.26856811
49DAPK21.26788134
50STK241.26723114
51TAOK21.26406411
52PDK11.26204668
53MST41.22577256
54MAP3K11.21701574
55PDK21.18302315
56FLT31.15530205
57FGFR41.15373716
58STK381.13911828
59MAP3K141.12710906
60LMTK21.11933061
61MAP3K41.11478088
62IRAK21.10632792
63TYK21.08489429
64DYRK1B1.08205531
65HIPK21.07963229
66MATK1.07458195
67STK101.06139309
68CDK61.06096868
69SYK1.03604753
70KDR0.99107827
71PDPK10.94711226
72TNK20.94487287
73PDGFRA0.92509980
74JAK30.92185279
75MARK10.91686056
76MAPK70.91444161
77PTK60.91286307
78JAK20.90937016
79TESK20.88670113
80PTK2B0.84958073
81MAP2K40.83178456
82EPHA30.82958452
83WNK10.76484166
84PAK30.74340691
85FGR0.73790340
86SIK10.72825839
87MAPK110.72320345
88MAPK120.72166178
89LRRK20.72093242
90YES10.70310241
91ICK0.69321840
92SIK20.69185274
93CDK120.66231607
94PDGFRB0.65947884
95TRPM70.65533514
96PTK20.64058593
97CDK40.63771947
98BMX0.63709985
99MAP3K120.63603699
100CDK50.61160315
101ALK0.60735574
102MAP3K50.60122667
103HCK0.58657604
104CDC42BPA0.57386310
105MAP2K10.57069827
106CAMK1G0.55986208
107FES0.54876115
108NEK90.54733851
109MOS0.54709675
110TXK0.53112102
111SGK30.52781282
112RPS6KA20.50192516
113KSR10.49317346
114TEC0.47364508
115MAP3K130.47209606
116MARK30.47158801
117MAP3K110.47025575
118TGFBR20.47004298
119EPHB10.46871345
120BRD40.46572805
121MAP3K80.45733886
122NLK0.45705607
123PIM10.44540300
124MAP3K30.43970554
125PAK20.43867294
126WNK40.43507352
127PRKCQ0.43177148
128CDK140.42424971
129EGFR0.42075837
130CHUK0.41948049
131SMG10.41530899
132RPS6KA40.40891840
133LCK0.40266519
134ABL10.39915998
135TIE10.39796926
136PRKCZ0.39700725
137INSRR0.39562974
138GRK60.38995317
139MAPK40.38929115
140FGFR20.38902003
141STK110.38872701
142MAP2K70.38722650
143NME20.38175592
144LATS20.37752985
145MAPKAPK20.37330455
146IRAK10.37216688
147FYN0.36848526
148RAF10.36369257
149PASK0.36081133
150GRK70.35488561
151ARAF0.32986351

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.13641535
2Allograft rejection_Homo sapiens_hsa053302.83639398
3Asthma_Homo sapiens_hsa053102.72449126
4Autoimmune thyroid disease_Homo sapiens_hsa053202.53696327
5Graft-versus-host disease_Homo sapiens_hsa053322.45566925
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29049014
7Staphylococcus aureus infection_Homo sapiens_hsa051502.08029238
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98464025
9Synaptic vesicle cycle_Homo sapiens_hsa047211.94971539
10Hematopoietic cell lineage_Homo sapiens_hsa046401.80431900
11Influenza A_Homo sapiens_hsa051641.77766642
12Viral myocarditis_Homo sapiens_hsa054161.66204059
13* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66041745
14B cell receptor signaling pathway_Homo sapiens_hsa046621.65143617
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62525258
16Other glycan degradation_Homo sapiens_hsa005111.59913403
17Osteoclast differentiation_Homo sapiens_hsa043801.56813684
18Herpes simplex infection_Homo sapiens_hsa051681.56627709
19Insulin secretion_Homo sapiens_hsa049111.53529939
20Type II diabetes mellitus_Homo sapiens_hsa049301.52716962
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48470624
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44672082
23Rheumatoid arthritis_Homo sapiens_hsa053231.43827384
24Long-term potentiation_Homo sapiens_hsa047201.43560559
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40018715
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39710201
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36826227
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33945114
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.28926270
30Amphetamine addiction_Homo sapiens_hsa050311.25849437
31Estrogen signaling pathway_Homo sapiens_hsa049151.18950339
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.17796679
33VEGF signaling pathway_Homo sapiens_hsa043701.17091845
34Hepatitis C_Homo sapiens_hsa051601.16197433
35Malaria_Homo sapiens_hsa051441.15977276
36Pancreatic secretion_Homo sapiens_hsa049721.15419959
37T cell receptor signaling pathway_Homo sapiens_hsa046601.15340426
38Glioma_Homo sapiens_hsa052141.14270297
39Leishmaniasis_Homo sapiens_hsa051401.11556788
40Nitrogen metabolism_Homo sapiens_hsa009101.11416928
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11342442
42Dopaminergic synapse_Homo sapiens_hsa047281.09971208
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08934859
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07171813
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06310134
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06119720
47Olfactory transduction_Homo sapiens_hsa047401.05807911
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.05639755
49Dorso-ventral axis formation_Homo sapiens_hsa043201.04707028
50Toxoplasmosis_Homo sapiens_hsa051451.03036055
51Circadian entrainment_Homo sapiens_hsa047131.02014548
52Apoptosis_Homo sapiens_hsa042101.01381849
53Cholinergic synapse_Homo sapiens_hsa047251.00684348
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98468375
55Chronic myeloid leukemia_Homo sapiens_hsa052200.98252930
56Salivary secretion_Homo sapiens_hsa049700.98094215
57Endocytosis_Homo sapiens_hsa041440.97832873
58Cocaine addiction_Homo sapiens_hsa050300.97134201
59Glucagon signaling pathway_Homo sapiens_hsa049220.97073453
60Antigen processing and presentation_Homo sapiens_hsa046120.96874356
61mTOR signaling pathway_Homo sapiens_hsa041500.96137042
62Prolactin signaling pathway_Homo sapiens_hsa049170.95917712
63Renin secretion_Homo sapiens_hsa049240.95822618
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95650592
65Pancreatic cancer_Homo sapiens_hsa052120.94915305
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94629869
67Tuberculosis_Homo sapiens_hsa051520.93873914
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92955956
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.92686176
70TNF signaling pathway_Homo sapiens_hsa046680.92332321
71Gastric acid secretion_Homo sapiens_hsa049710.92224088
72Insulin resistance_Homo sapiens_hsa049310.92030743
73Vibrio cholerae infection_Homo sapiens_hsa051100.91692894
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91017947
75Epstein-Barr virus infection_Homo sapiens_hsa051690.90570599
76Lysosome_Homo sapiens_hsa041420.90494435
77Thyroid hormone synthesis_Homo sapiens_hsa049180.89301281
78Chemokine signaling pathway_Homo sapiens_hsa040620.89117935
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89029807
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87900824
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85668898
82Primary immunodeficiency_Homo sapiens_hsa053400.85478351
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.85326833
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84458793
85Type I diabetes mellitus_Homo sapiens_hsa049400.84359225
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.83973487
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83581559
88GABAergic synapse_Homo sapiens_hsa047270.81987602
89Oxytocin signaling pathway_Homo sapiens_hsa049210.81481611
90Legionellosis_Homo sapiens_hsa051340.80178027
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77953498
92Viral carcinogenesis_Homo sapiens_hsa052030.77918648
93Platelet activation_Homo sapiens_hsa046110.77881654
94African trypanosomiasis_Homo sapiens_hsa051430.76768942
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76708745
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76484504
97Salmonella infection_Homo sapiens_hsa051320.75766336
98Non-small cell lung cancer_Homo sapiens_hsa052230.75727565
99Morphine addiction_Homo sapiens_hsa050320.75221990
100Insulin signaling pathway_Homo sapiens_hsa049100.72450087
101Endometrial cancer_Homo sapiens_hsa052130.72177623
102Renal cell carcinoma_Homo sapiens_hsa052110.71889139
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.71790845
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71442801
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71372043
106HTLV-I infection_Homo sapiens_hsa051660.71163683
107Shigellosis_Homo sapiens_hsa051310.71145789
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70905998
109Hepatitis B_Homo sapiens_hsa051610.70468966
110GnRH signaling pathway_Homo sapiens_hsa049120.69767690
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69724574
112Prion diseases_Homo sapiens_hsa050200.69236832
113Prostate cancer_Homo sapiens_hsa052150.68977265
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68853515
115cAMP signaling pathway_Homo sapiens_hsa040240.68790823
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66163981
117Acute myeloid leukemia_Homo sapiens_hsa052210.66130451
118MAPK signaling pathway_Homo sapiens_hsa040100.65798438
119Phagosome_Homo sapiens_hsa041450.64458232
120Measles_Homo sapiens_hsa051620.64339788
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.64218105
122N-Glycan biosynthesis_Homo sapiens_hsa005100.62859416
123FoxO signaling pathway_Homo sapiens_hsa040680.62472879
124Renin-angiotensin system_Homo sapiens_hsa046140.61032120
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.60026830
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60025947
127ErbB signaling pathway_Homo sapiens_hsa040120.59752015
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58883306
129Glutamatergic synapse_Homo sapiens_hsa047240.58326823
130Bladder cancer_Homo sapiens_hsa052190.58324181
131Pertussis_Homo sapiens_hsa051330.58202603
132Amoebiasis_Homo sapiens_hsa051460.58168745
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57852010
134Sulfur metabolism_Homo sapiens_hsa009200.55437500
135Colorectal cancer_Homo sapiens_hsa052100.55127192
136Systemic lupus erythematosus_Homo sapiens_hsa053220.54584076
137Small cell lung cancer_Homo sapiens_hsa052220.53716964
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49774001
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49045938
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.43098002
141Inositol phosphate metabolism_Homo sapiens_hsa005620.41772749
142Sphingolipid metabolism_Homo sapiens_hsa006000.39194192
143HIF-1 signaling pathway_Homo sapiens_hsa040660.36592602
144Choline metabolism in cancer_Homo sapiens_hsa052310.33587934
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27334043

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