UBE2K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.18666296
2mitotic metaphase plate congression (GO:0007080)5.16800801
3establishment of integrated proviral latency (GO:0075713)5.04544327
4kinetochore assembly (GO:0051382)4.72745578
5kinetochore organization (GO:0051383)4.59718748
6regulation of sister chromatid cohesion (GO:0007063)4.56185876
7metaphase plate congression (GO:0051310)4.48288581
8DNA replication checkpoint (GO:0000076)4.43748476
9mitotic sister chromatid segregation (GO:0000070)4.15266534
10heterochromatin organization (GO:0070828)4.14010072
11regulation of nuclear cell cycle DNA replication (GO:0033262)4.03003002
12meiotic chromosome segregation (GO:0045132)3.99883429
13nuclear pore complex assembly (GO:0051292)3.97303029
14protein localization to kinetochore (GO:0034501)3.97015639
15mitotic sister chromatid cohesion (GO:0007064)3.92884262
16establishment of chromosome localization (GO:0051303)3.91685362
17pre-miRNA processing (GO:0031054)3.89795345
18non-recombinational repair (GO:0000726)3.85700354
19double-strand break repair via nonhomologous end joining (GO:0006303)3.85700354
20nuclear pore organization (GO:0006999)3.83663258
21regulation of double-strand break repair via homologous recombination (GO:0010569)3.76914042
22attachment of spindle microtubules to kinetochore (GO:0008608)3.71683550
23cellular protein complex localization (GO:0034629)3.67556091
24chromatin remodeling at centromere (GO:0031055)3.65955392
25spindle checkpoint (GO:0031577)3.64446793
26CENP-A containing nucleosome assembly (GO:0034080)3.63459596
27maturation of 5.8S rRNA (GO:0000460)3.63321488
28protein K6-linked ubiquitination (GO:0085020)3.62347701
29DNA double-strand break processing (GO:0000729)3.59126303
30regulation of mitotic spindle checkpoint (GO:1903504)3.57067991
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57067991
32establishment of viral latency (GO:0019043)3.55123000
33protein localization to chromosome, centromeric region (GO:0071459)3.54680000
34sister chromatid cohesion (GO:0007062)3.54010331
35sister chromatid segregation (GO:0000819)3.52948219
36regulation of translational fidelity (GO:0006450)3.52482324
37folic acid-containing compound biosynthetic process (GO:0009396)3.51626625
38formation of translation preinitiation complex (GO:0001731)3.48818200
39DNA replication-independent nucleosome organization (GO:0034724)3.47149546
40DNA replication-independent nucleosome assembly (GO:0006336)3.47149546
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.45302228
42piRNA metabolic process (GO:0034587)3.44838327
43mitotic chromosome condensation (GO:0007076)3.44787242
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.44584036
45spindle assembly checkpoint (GO:0071173)3.44581662
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.44275840
47negative regulation of chromosome segregation (GO:0051985)3.43787299
48mitotic nuclear envelope disassembly (GO:0007077)3.43318795
49maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.41597730
50mitotic spindle assembly checkpoint (GO:0007094)3.41011430
51DNA topological change (GO:0006265)3.40035969
52histone exchange (GO:0043486)3.39647666
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.39446505
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.39446505
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.39446505
56negative regulation of sister chromatid segregation (GO:0033046)3.39446505
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.38290466
58mitotic spindle checkpoint (GO:0071174)3.37821745
59microtubule depolymerization (GO:0007019)3.36002833
60mRNA stabilization (GO:0048255)3.34910215
61RNA stabilization (GO:0043489)3.34910215
62regulation of telomere maintenance via telomerase (GO:0032210)3.34185202
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32138946
64regulation of double-strand break repair (GO:2000779)3.29884876
65membrane disassembly (GO:0030397)3.29369149
66nuclear envelope disassembly (GO:0051081)3.29369149
67IMP biosynthetic process (GO:0006188)3.28995024
68DNA replication initiation (GO:0006270)3.28864401
69regulation of mitotic sister chromatid separation (GO:0010965)3.28516978
70regulation of mitotic sister chromatid segregation (GO:0033047)3.28516978
71regulation of sister chromatid segregation (GO:0033045)3.28516978
72chromosome segregation (GO:0007059)3.28264046
73ribosome biogenesis (GO:0042254)3.26628564
74localization within membrane (GO:0051668)3.23003021
75regulation of RNA export from nucleus (GO:0046831)3.22817302
76replication fork processing (GO:0031297)3.19612957
77IMP metabolic process (GO:0046040)3.19291920
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.19171582
79positive regulation of mitotic sister chromatid separation (GO:1901970)3.19171582
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.19171582
81regulation of centriole replication (GO:0046599)3.18737694
82DNA strand elongation (GO:0022616)3.18280773
83ribosome assembly (GO:0042255)3.17347110
84regulation of chromosome segregation (GO:0051983)3.17017901
85regulation of stem cell maintenance (GO:2000036)3.13559446
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11613785
87DNA replication-dependent nucleosome assembly (GO:0006335)3.09981176
88DNA replication-dependent nucleosome organization (GO:0034723)3.09981176
89protein localization to chromosome (GO:0034502)3.04585092
90regulation of spindle organization (GO:0090224)3.03918484
91ATP-dependent chromatin remodeling (GO:0043044)2.99437050
92L-serine metabolic process (GO:0006563)2.96818610
93regulation of centrosome cycle (GO:0046605)2.94965792
94pore complex assembly (GO:0046931)2.94914851
95negative regulation of dendrite morphogenesis (GO:0050774)2.92356861
96protein deneddylation (GO:0000338)2.91047171
97protein complex localization (GO:0031503)2.90842678
98prenylation (GO:0097354)2.89572927
99protein prenylation (GO:0018342)2.89572927
100telomere maintenance via recombination (GO:0000722)2.89252493
101regulation of spindle checkpoint (GO:0090231)2.87578279
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86931422
103regulation of gene silencing by RNA (GO:0060966)2.86809905
104regulation of posttranscriptional gene silencing (GO:0060147)2.86809905
105regulation of gene silencing by miRNA (GO:0060964)2.86809905
106cullin deneddylation (GO:0010388)2.86104877
107positive regulation of DNA-dependent DNA replication (GO:2000105)2.86050189
108telomere maintenance via telomerase (GO:0007004)2.85243868
109positive regulation of chromosome segregation (GO:0051984)2.85220626
110telomere maintenance via semi-conservative replication (GO:0032201)2.84459239
111regulation of telomere maintenance (GO:0032204)2.83082921
112resolution of meiotic recombination intermediates (GO:0000712)2.82275893
113meiotic nuclear division (GO:0007126)2.81321283
114histone H2B ubiquitination (GO:0033523)2.80506591
115DNA strand elongation involved in DNA replication (GO:0006271)2.77170709
116chromatin assembly or disassembly (GO:0006333)2.76642429
117histone H4-K12 acetylation (GO:0043983)2.76500092
118DNA methylation involved in gamete generation (GO:0043046)2.76389360
119peptidyl-lysine dimethylation (GO:0018027)2.76091499
120regulation of mitotic spindle organization (GO:0060236)2.75384037
121paraxial mesoderm development (GO:0048339)2.74926655
122negative regulation of mitosis (GO:0045839)2.73959541
123Golgi transport vesicle coating (GO:0048200)2.73570384
124COPI coating of Golgi vesicle (GO:0048205)2.73570384
125meiotic cell cycle (GO:0051321)2.72854565
126mitotic recombination (GO:0006312)2.72339193
127reciprocal meiotic recombination (GO:0007131)2.71481735
128reciprocal DNA recombination (GO:0035825)2.71481735
129telomere maintenance via telomere lengthening (GO:0010833)2.70828844
130regulation of DNA-dependent DNA replication (GO:0090329)2.70547678
131negative regulation of histone methylation (GO:0031061)2.70534304
132notochord development (GO:0030903)2.70253141
133proteasome assembly (GO:0043248)2.70055833
134rRNA modification (GO:0000154)2.69707930
135purine nucleobase biosynthetic process (GO:0009113)2.69647563
136protein-DNA complex disassembly (GO:0032986)2.68417924
137nucleosome disassembly (GO:0006337)2.68417924
138ribosomal small subunit assembly (GO:0000028)2.68144323
139regulation of mRNA stability (GO:0043488)2.67944539
140NLS-bearing protein import into nucleus (GO:0006607)2.67772957
141regulation of nucleobase-containing compound transport (GO:0032239)2.67573010
142DNA duplex unwinding (GO:0032508)2.67441429
143coenzyme A biosynthetic process (GO:0015937)2.67246746
144negative regulation of mRNA metabolic process (GO:1903312)2.59145298
145nucleobase-containing small molecule interconversion (GO:0015949)2.58868517
1463-UTR-mediated mRNA stabilization (GO:0070935)2.58267952
147protein localization to microtubule (GO:0035372)2.56625538
148DNA geometric change (GO:0032392)2.54783377
149regulation of histone H3-K9 methylation (GO:0051570)2.53330211
150regulation of helicase activity (GO:0051095)2.51438449
151positive regulation of histone H3-K4 methylation (GO:0051571)2.51053920
152protein export from nucleus (GO:0006611)2.50179139
153regulation of transcription from RNA polymerase I promoter (GO:0006356)2.48852809
154negative regulation of RNA splicing (GO:0033119)2.47760343
155positive regulation of SMAD protein import into nucleus (GO:0060391)2.47677754
156tetrahydrofolate metabolic process (GO:0046653)2.47574591
157chromosome condensation (GO:0030261)2.47117760
158negative regulation of mRNA processing (GO:0050686)2.46891348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.68553634
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.51202796
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13840113
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.74528987
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.42203897
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.02485657
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01361190
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.95161166
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.86331249
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.73484616
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55101074
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.33317986
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30230359
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.29977833
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.29042274
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27888816
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15719012
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11005661
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06852138
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.05478119
21AR_21909140_ChIP-Seq_LNCAP_Human1.92816434
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91475746
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90253059
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.87013818
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86916081
26GATA1_22025678_ChIP-Seq_K562_Human1.86329396
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85735225
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85425597
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81771382
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75789900
31CLOCK_20551151_ChIP-Seq_293T_Human1.75663403
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74684562
33ZNF263_19887448_ChIP-Seq_K562_Human1.67496904
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64191804
35VDR_23849224_ChIP-Seq_CD4+_Human1.63904935
36ELK1_19687146_ChIP-ChIP_HELA_Human1.62712836
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.60534980
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57099090
39FUS_26573619_Chip-Seq_HEK293_Human1.55791930
40TTF2_22483619_ChIP-Seq_HELA_Human1.54637587
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53696506
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53059109
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49332605
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47906693
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47857589
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46297022
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46297022
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46297022
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45913965
50CHD1_26751641_Chip-Seq_LNCaP_Human1.42400994
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40565791
52GABP_19822575_ChIP-Seq_HepG2_Human1.39457538
53FOXP3_21729870_ChIP-Seq_TREG_Human1.38540238
54MYC_18940864_ChIP-ChIP_HL60_Human1.38194821
55XRN2_22483619_ChIP-Seq_HELA_Human1.37424127
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.36320728
57DCP1A_22483619_ChIP-Seq_HELA_Human1.36088876
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36014763
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35638335
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35544422
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34832840
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33388649
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32056338
64TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.31216178
65EWS_26573619_Chip-Seq_HEK293_Human1.30453064
66SOX17_20123909_ChIP-Seq_XEN_Mouse1.28607031
67KDM5A_27292631_Chip-Seq_BREAST_Human1.27890886
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27514972
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27096644
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25878112
71IGF1R_20145208_ChIP-Seq_DFB_Human1.25263202
72RNF2_27304074_Chip-Seq_NSC_Mouse1.22855192
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21256344
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20640606
75* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18866550
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17613776
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16684608
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15457462
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15309889
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14950571
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14236853
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.13212835
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12391788
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12003931
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11421926
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11417220
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.10355692
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10321817
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09965832
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08808966
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08554939
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.08216452
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07387802
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05864907
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05693456
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.05008190
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03551014
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01275927
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00614423
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99929921
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99337983
102MYC_22102868_ChIP-Seq_BL_Human0.98854260
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96130646
104KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95372799
105TFEB_21752829_ChIP-Seq_HELA_Human0.94757681
106REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94421789
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94057165
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91620209
109TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91246346
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91184104
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91128164
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90195539
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89847523
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89667325
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.88175598
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86548095
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.86404193
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83823295
119* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83569548
120PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83449802
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81176477
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80785755
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.79824053
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79785612
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79493779
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.79436713
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78641404
128NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78274301
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.77318847
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77071469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.29055074
2MP0008877_abnormal_DNA_methylation3.68717084
3MP0006292_abnormal_olfactory_placode3.57984990
4MP0010094_abnormal_chromosome_stability3.55968804
5MP0003111_abnormal_nucleus_morphology3.36672029
6MP0004957_abnormal_blastocyst_morpholog3.18936819
7MP0003077_abnormal_cell_cycle3.06233233
8MP0008057_abnormal_DNA_replication3.01927374
9MP0008058_abnormal_DNA_repair2.75588708
10MP0002877_abnormal_melanocyte_morpholog2.63768182
11MP0003123_paternal_imprinting2.60504301
12MP0010234_abnormal_vibrissa_follicle2.60382594
13MP0008932_abnormal_embryonic_tissue2.51174763
14MP0003890_abnormal_embryonic-extraembry2.39699670
15MP0008007_abnormal_cellular_replicative2.38622620
16MP0003121_genomic_imprinting2.31379716
17MP0010352_gastrointestinal_tract_polyps2.30381125
18MP0003941_abnormal_skin_development2.25355466
19MP0003787_abnormal_imprinting2.23579479
20MP0003718_maternal_effect1.95396946
21MP0010030_abnormal_orbit_morphology1.85109148
22MP0002210_abnormal_sex_determination1.78585127
23MP0000350_abnormal_cell_proliferation1.77116012
24MP0001188_hyperpigmentation1.76325452
25MP0009697_abnormal_copulation1.73539308
26MP0002796_impaired_skin_barrier1.71459764
27MP0001730_embryonic_growth_arrest1.67969679
28MP0002102_abnormal_ear_morphology1.62014712
29MP0002697_abnormal_eye_size1.61530305
30MP0003786_premature_aging1.59893007
31MP0005501_abnormal_skin_physiology1.59748142
32MP0003705_abnormal_hypodermis_morpholog1.58258812
33MP0005380_embryogenesis_phenotype1.56930688
34MP0001672_abnormal_embryogenesis/_devel1.56930688
35MP0000566_synostosis1.56823777
36MP0004185_abnormal_adipocyte_glucose1.56219724
37MP0003937_abnormal_limbs/digits/tail_de1.54104101
38MP0000537_abnormal_urethra_morphology1.53258114
39MP0002085_abnormal_embryonic_tissue1.52871902
40MP0002084_abnormal_developmental_patter1.52074098
41MP0005248_abnormal_Harderian_gland1.51590136
42MP0003315_abnormal_perineum_morphology1.47304483
43MP0001697_abnormal_embryo_size1.43078461
44MP0003566_abnormal_cell_adhesion1.42924112
45MP0003755_abnormal_palate_morphology1.41530996
46MP0004270_analgesia1.41226735
47MP0000653_abnormal_sex_gland1.39481231
48MP0003984_embryonic_growth_retardation1.38479878
49MP0003136_yellow_coat_color1.38078165
50MP0001145_abnormal_male_reproductive1.35762800
51MP0002088_abnormal_embryonic_growth/wei1.34592981
52MP0001119_abnormal_female_reproductive1.34169876
53MP0003115_abnormal_respiratory_system1.33210392
54MP0002160_abnormal_reproductive_system1.32380500
55MP0004859_abnormal_synaptic_plasticity1.31360184
56MP0001929_abnormal_gametogenesis1.29256102
57MP0001293_anophthalmia1.28598094
58MP0002163_abnormal_gland_morphology1.27459224
59MP0003119_abnormal_digestive_system1.21871218
60MP0008789_abnormal_olfactory_epithelium1.20826639
61MP0002396_abnormal_hematopoietic_system1.19101074
62MP0005499_abnormal_olfactory_system1.16944632
63MP0005394_taste/olfaction_phenotype1.16944632
64MP0009250_abnormal_appendicular_skeleto1.13498622
65MP0000579_abnormal_nail_morphology1.13301772
66MP0003122_maternal_imprinting1.13266220
67MP0001299_abnormal_eye_distance/1.10928252
68MP0000516_abnormal_urinary_system1.09680275
69MP0005367_renal/urinary_system_phenotyp1.09680275
70MP0002086_abnormal_extraembryonic_tissu1.09387432
71MP0010678_abnormal_skin_adnexa1.08281973
72MP0003861_abnormal_nervous_system1.04665785
73MP0001915_intracranial_hemorrhage1.04562878
74MP0004264_abnormal_extraembryonic_tissu1.03851373
75MP0002080_prenatal_lethality1.02665797
76MP0003453_abnormal_keratinocyte_physiol1.01705393
77MP0000467_abnormal_esophagus_morphology1.00977437
78MP0002938_white_spotting1.00159518
79MP0003942_abnormal_urinary_system0.98541807
80MP0001286_abnormal_eye_development0.98477428
81MP0000432_abnormal_head_morphology0.98468410
82MP0002092_abnormal_eye_morphology0.98089790
83MP0003646_muscle_fatigue0.98049278
84MP0003938_abnormal_ear_development0.97861796
85MP0002254_reproductive_system_inflammat0.97463850
86MP0002249_abnormal_larynx_morphology0.94305402
87MP0009672_abnormal_birth_weight0.93890749
88MP0003935_abnormal_craniofacial_develop0.93078555
89MP0005389_reproductive_system_phenotype0.92817064
90MP0001919_abnormal_reproductive_system0.92323242
91MP0002081_perinatal_lethality0.92103121
92MP0005187_abnormal_penis_morphology0.91703630
93MP0003385_abnormal_body_wall0.91456011
94MP0003698_abnormal_male_reproductive0.91183605
95MP0002116_abnormal_craniofacial_bone0.91099484
96MP0005623_abnormal_meninges_morphology0.91058345
97MP0001346_abnormal_lacrimal_gland0.90770236
98MP0004272_abnormal_basement_membrane0.90475065
99MP0002009_preneoplasia0.89905369
100MP0000358_abnormal_cell_content/0.89220475
101MP0003699_abnormal_female_reproductive0.89184555
102MP0009053_abnormal_anal_canal0.88452110
103MP0000313_abnormal_cell_death0.87255090
104MP0003221_abnormal_cardiomyocyte_apopto0.86184180
105MP0000049_abnormal_middle_ear0.86178483
106MP0002653_abnormal_ependyma_morphology0.85904028
107MP0004233_abnormal_muscle_weight0.84532432
108MP0005384_cellular_phenotype0.84155514
109MP0000631_abnormal_neuroendocrine_gland0.83777019
110MP0000428_abnormal_craniofacial_morphol0.80739723
111MP0000015_abnormal_ear_pigmentation0.80712125
112MP0009703_decreased_birth_body0.80501045
113MP0003567_abnormal_fetal_cardiomyocyte0.80053063
114MP0002177_abnormal_outer_ear0.79731606
115MP0002114_abnormal_axial_skeleton0.78285262
116MP0002277_abnormal_respiratory_mucosa0.77839263
117MP0005621_abnormal_cell_physiology0.77378267
118MP0005666_abnormal_adipose_tissue0.76882753
119MP0000762_abnormal_tongue_morphology0.75923113
120MP0002751_abnormal_autonomic_nervous0.75606562
121MP0004197_abnormal_fetal_growth/weight/0.75571541
122MP0002161_abnormal_fertility/fecundity0.75251167
123MP0005257_abnormal_intraocular_pressure0.75010322
124MP0001177_atelectasis0.74939418
125MP0006035_abnormal_mitochondrial_morpho0.74930635
126MP0000613_abnormal_salivary_gland0.74263098
127MP0005409_darkened_coat_color0.73136860
128MP0000377_abnormal_hair_follicle0.71620752
129MP0005076_abnormal_cell_differentiation0.70523069
130MP0010307_abnormal_tumor_latency0.70287254
131MP0000490_abnormal_crypts_of0.70084864
132MP0002090_abnormal_vision0.69691863
133MP0002233_abnormal_nose_morphology0.69423976
134MP0000534_abnormal_ureter_morphology0.69216724
135MP0000778_abnormal_nervous_system0.69120595
136MP0001849_ear_inflammation0.68884172
137MP0002184_abnormal_innervation0.68452233
138MP0002019_abnormal_tumor_incidence0.68155945
139MP0002111_abnormal_tail_morphology0.67598533
140MP0003828_pulmonary_edema0.65364717
141MP0002109_abnormal_limb_morphology0.64488427
142MP0000383_abnormal_hair_follicle0.64115169
143MP0010630_abnormal_cardiac_muscle0.63642385
144MP0009379_abnormal_foot_pigmentation0.63518971
145MP0002734_abnormal_mechanical_nocicepti0.62888081
146MP0002075_abnormal_coat/hair_pigmentati0.62689418
147* MP0004811_abnormal_neuron_physiology0.60659473
148MP0001340_abnormal_eyelid_morphology0.60292491
149MP0008770_decreased_survivor_rate0.59809741

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.51347604
2Chromsome breakage (HP:0040012)4.37437630
3Abnormality of the labia minora (HP:0012880)4.19586013
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.01539871
5Patellar aplasia (HP:0006443)3.60425754
6Breast hypoplasia (HP:0003187)3.52235347
7Progressive muscle weakness (HP:0003323)3.41508188
8Meckel diverticulum (HP:0002245)3.41169142
9Aplasia/Hypoplasia of the patella (HP:0006498)3.35424149
10Abnormality of the ileum (HP:0001549)3.23593776
11Cortical dysplasia (HP:0002539)3.20686247
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.15662994
13Ectopic kidney (HP:0000086)3.14977400
14Facial hemangioma (HP:0000329)3.05350380
15Abnormality of chromosome stability (HP:0003220)3.04751687
16Papillary thyroid carcinoma (HP:0002895)3.02582842
17Abnormality of the preputium (HP:0100587)3.01702274
18Multiple enchondromatosis (HP:0005701)2.84198066
19Long foot (HP:0001833)2.71439703
20Volvulus (HP:0002580)2.70739604
21Abnormal lung lobation (HP:0002101)2.70683904
22Termporal pattern (HP:0011008)2.69357663
23Insidious onset (HP:0003587)2.69357663
24Supernumerary spleens (HP:0009799)2.68506291
25Adrenal hypoplasia (HP:0000835)2.64716010
26Shawl scrotum (HP:0000049)2.61861221
27Nephroblastoma (Wilms tumor) (HP:0002667)2.57615430
28Small intestinal stenosis (HP:0012848)2.57331352
29Duodenal stenosis (HP:0100867)2.57331352
30Abnormality of the phalanges of the hallux (HP:0010057)2.56678014
31Absent radius (HP:0003974)2.56627461
32Medulloblastoma (HP:0002885)2.55545671
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.54172965
34Hepatoblastoma (HP:0002884)2.49556070
35Spastic diplegia (HP:0001264)2.49389091
36Breast aplasia (HP:0100783)2.49116325
37Embryonal renal neoplasm (HP:0011794)2.45343881
38Rib fusion (HP:0000902)2.42298541
39Ankyloglossia (HP:0010296)2.42177536
40Impulsivity (HP:0100710)2.39974778
41Aplasia involving forearm bones (HP:0009822)2.39653708
42Absent forearm bone (HP:0003953)2.39653708
43Capillary hemangiomas (HP:0005306)2.38693726
44Autoamputation (HP:0001218)2.37366296
45Deviation of the thumb (HP:0009603)2.34982585
46Aplasia/Hypoplasia of the breasts (HP:0010311)2.34290577
47Rhabdomyosarcoma (HP:0002859)2.33871818
48Overlapping toe (HP:0001845)2.33357078
49Proximal placement of thumb (HP:0009623)2.30090337
50Oligodactyly (HP:0012165)2.29103002
51Insomnia (HP:0100785)2.28458371
52Myelodysplasia (HP:0002863)2.26982529
53Selective tooth agenesis (HP:0001592)2.23081609
54Microglossia (HP:0000171)2.20629877
55Triphalangeal thumb (HP:0001199)2.20251303
56Horseshoe kidney (HP:0000085)2.14551284
57Transposition of the great arteries (HP:0001669)2.12803493
58Abnormal connection of the cardiac segments (HP:0011545)2.12803493
59Abnormal ventriculo-arterial connection (HP:0011563)2.12803493
60Abnormal spermatogenesis (HP:0008669)2.11758174
61Absent thumb (HP:0009777)2.05310105
62Sloping forehead (HP:0000340)2.04633461
63Malignant gastrointestinal tract tumors (HP:0006749)2.04365260
64Gastrointestinal carcinoma (HP:0002672)2.04365260
65Abnormality of the duodenum (HP:0002246)2.02931618
66Pendular nystagmus (HP:0012043)2.02882564
67Carpal bone hypoplasia (HP:0001498)2.00230127
68Thyroid carcinoma (HP:0002890)1.98046853
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96257369
70Clubbing of toes (HP:0100760)1.95675726
71Right ventricular cardiomyopathy (HP:0011663)1.95093480
72Azoospermia (HP:0000027)1.93358963
73Uterine neoplasm (HP:0010784)1.92868312
74Dysmetric saccades (HP:0000641)1.92026005
75Leiomyosarcoma (HP:0100243)1.91845666
76Uterine leiomyosarcoma (HP:0002891)1.91845666
77Atresia of the external auditory canal (HP:0000413)1.91540918
78Cleft eyelid (HP:0000625)1.91112404
79Cystic hygroma (HP:0000476)1.90952654
80Abnormality of the carotid arteries (HP:0005344)1.90580818
81Acute lymphatic leukemia (HP:0006721)1.89120004
82Transitional cell carcinoma of the bladder (HP:0006740)1.88440638
83Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87971148
84Biliary tract neoplasm (HP:0100574)1.87069730
85Hammertoe (HP:0001765)1.86951704
86Orthostatic hypotension (HP:0001278)1.86758740
87Asymmetry of the thorax (HP:0001555)1.85730573
88Increased number of teeth (HP:0011069)1.85723311
89Postnatal microcephaly (HP:0005484)1.84326412
90Progressive external ophthalmoplegia (HP:0000590)1.82964698
91Neuroblastoma (HP:0003006)1.81546224
92Primitive neuroectodermal tumor (HP:0030065)1.81546224
93Neuroblastic tumors (HP:0004376)1.81546224
94Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.81546224
95Tracheoesophageal fistula (HP:0002575)1.81141658
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80889610
97Abnormal cartilage morphology (HP:0002763)1.80431009
98Premature graying of hair (HP:0002216)1.79659804
99Abnormality of the salivary glands (HP:0010286)1.79488121
100Obstructive sleep apnea (HP:0002870)1.79263504
101Exercise-induced muscle cramps (HP:0003710)1.77020331
102Rough bone trabeculation (HP:0100670)1.76822196
103Abnormality of the nasal septum (HP:0000419)1.76500282
104Short thumb (HP:0009778)1.75371683
105Overriding aorta (HP:0002623)1.74673724
106Large hands (HP:0001176)1.74493588
107Abnormality of the anterior horn cell (HP:0006802)1.74357525
108Degeneration of anterior horn cells (HP:0002398)1.74357525
109Facial cleft (HP:0002006)1.73778914
110Missing ribs (HP:0000921)1.73394138
111Shoulder girdle muscle weakness (HP:0003547)1.73393630
112Pelvic girdle muscle weakness (HP:0003749)1.73225711
113Sparse lateral eyebrow (HP:0005338)1.72940247
114Impaired vibration sensation in the lower limbs (HP:0002166)1.72794999
115Pancreatic fibrosis (HP:0100732)1.72561493
116Abnormality of chromosome segregation (HP:0002916)1.72450502
117Menstrual irregularities (HP:0000858)1.72422345
118Obsessive-compulsive behavior (HP:0000722)1.72309793
119Hypoglycemic seizures (HP:0002173)1.71736129
120Lip pit (HP:0100267)1.71475589
121Febrile seizures (HP:0002373)1.71409714
122Back pain (HP:0003418)1.70410764
123Intestinal fistula (HP:0100819)1.70301998
124Bladder carcinoma (HP:0002862)1.69920913
125Bladder neoplasm (HP:0009725)1.69920913
126Concave nail (HP:0001598)1.69574170
127Abnormal auditory evoked potentials (HP:0006958)1.69547568
128Acute myeloid leukemia (HP:0004808)1.68726227
129Aganglionic megacolon (HP:0002251)1.68609337
130Long eyelashes (HP:0000527)1.68125021
131Oral leukoplakia (HP:0002745)1.67798324
132Neoplasm of striated muscle (HP:0009728)1.67339256
133Pancreatic cysts (HP:0001737)1.67216548
134Abnormality of glycolysis (HP:0004366)1.66164795
135Abnormality of the aortic arch (HP:0012303)1.65759718
136Abnormality of abdominal situs (HP:0011620)1.65743176
137Abdominal situs inversus (HP:0003363)1.65743176
138Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65494197
139Abnormality of the labia (HP:0000058)1.65337667
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64696950
141Lower limb amyotrophy (HP:0007210)1.64675227
142Short middle phalanx of the 5th finger (HP:0004220)1.64585618
143Increased nuchal translucency (HP:0010880)1.64154350
144Deep philtrum (HP:0002002)1.63899388
145Fetal akinesia sequence (HP:0001989)1.63531152
146Septate vagina (HP:0001153)1.63344377
147Bone marrow hypocellularity (HP:0005528)1.63227993
148Choanal stenosis (HP:0000452)1.62819543
149Neoplasm of the small intestine (HP:0100833)1.61180382
150Abnormality of oral frenula (HP:0000190)1.61143621
151Rectovaginal fistula (HP:0000143)1.61067590
152Rectal fistula (HP:0100590)1.61067590
153Absent eyebrow (HP:0002223)1.60997848
154Embryonal neoplasm (HP:0002898)1.59997748
155Curly hair (HP:0002212)1.59873782
156Arteriovenous malformation (HP:0100026)1.58918978
157Small hand (HP:0200055)1.58915663
158High anterior hairline (HP:0009890)1.58840755
159Myelomeningocele (HP:0002475)1.58569093
160Abnormality of the intervertebral disk (HP:0005108)1.57711195
161Colon cancer (HP:0003003)1.57639830
162Aplasia/Hypoplasia involving the musculature (HP:0001460)1.57588506
163Omphalocele (HP:0001539)1.57497505
164Gout (HP:0001997)1.57215481
165Bifid tongue (HP:0010297)1.56561555
166Arnold-Chiari malformation (HP:0002308)1.56109875
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.55480938
168Myokymia (HP:0002411)1.55449254
169Cubitus valgus (HP:0002967)1.53156974
170Increased serum pyruvate (HP:0003542)1.51499766
171Pseudobulbar signs (HP:0002200)1.48857007
172Skull defect (HP:0001362)1.48371363
173Pheochromocytoma (HP:0002666)1.47637475
174Webbed neck (HP:0000465)1.46321146
175Long palpebral fissure (HP:0000637)1.45656121
176Attention deficit hyperactivity disorder (HP:0007018)1.45461950
177Dysphonia (HP:0001618)1.44887060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.74554245
2LATS23.57587536
3PLK43.54596807
4LATS13.45585587
5STK38L3.42751755
6BUB13.27951520
7EIF2AK12.38963675
8TTK2.21628378
9WEE12.19404276
10SRPK12.19123004
11MKNK22.11769754
12BRSK22.11340182
13MAP3K62.02707529
14CDK122.02510847
15AKT31.98001411
16MST41.92608119
17CHEK21.89255100
18TAF11.88321392
19PLK11.86267114
20ACVR1B1.81575912
21CDK81.80568319
22PLK31.76349250
23PRPF4B1.68617524
24MARK11.61916625
25NEK21.54576129
26MAP2K71.53733330
27MAP3K101.53002276
28SCYL21.52746793
29ZAK1.47971686
30PBK1.45405390
31SMG11.42155989
32PLK21.37863208
33MKNK11.37665195
34TNIK1.35077440
35STK31.32299474
36BRSK11.31004560
37DYRK21.28197021
38SIK31.23395514
39DMPK1.22946973
40PNCK1.22598290
41CDK71.20561590
42BRAF1.19010985
43ERBB41.18027912
44TAOK11.17363063
45ARAF1.13163267
46CHEK11.13118405
47MAP3K41.11341927
48EEF2K1.11100100
49AURKB1.08182735
50NTRK11.05876783
51MAPK131.04040687
52ATM1.03357377
53STK381.01560661
54AURKA1.01161612
55MAP3K81.00341305
56ATR0.99826536
57CAMK1G0.96651354
58NEK10.94862959
59STK240.91967991
60VRK10.87176832
61TAOK20.86360727
62MINK10.85369847
63TRIM280.83997073
64EIF2AK30.82649412
65BCR0.80892825
66CDK20.80835774
67BMPR20.80647022
68FGFR10.80426162
69EIF2AK20.80038813
70PDGFRA0.79639075
71CAMK1D0.79598914
72IRAK30.77387733
73PASK0.76934410
74KSR20.75014864
75ABL20.74660761
76PRKD30.74554316
77RPS6KB20.72793896
78STK160.72020996
79CASK0.71446991
80CDK30.70628863
81NUAK10.70350351
82PINK10.69142058
83VRK20.69089010
84PAK40.67547237
85ALK0.67484941
86DYRK30.67310369
87NME20.67284185
88CDK180.66777620
89MELK0.66396067
90MAP3K50.65665914
91ICK0.65368474
92CDK10.64545605
93CDK150.62681481
94ERBB30.59319152
95CDK11A0.59276553
96MAP2K40.59258398
97CDK140.58879103
98IRAK20.58706364
99TLK10.57340566
100BMX0.56324829
101DAPK10.55996141
102IRAK10.55590945
103PTK20.55526047
104MST1R0.53609673
105NEK90.52462486
106PRKCI0.52421589
107MET0.52335136
108MAP3K90.51317406
109KSR10.51303917
110GRK50.51129198
111WNK10.50307564
112TYRO30.48227330
113TSSK60.47472095
114CCNB10.46977777
115STK40.46864027
116NTRK30.45799838
117MAPK100.44347248
118SGK20.44322799
119RPS6KA40.43993967
120ADRBK20.42853750
121CDK90.42681152
122PRKD20.42360217
123NEK60.41999454
124CSNK2A10.41232562
125CSNK1E0.41137552
126YES10.41046938
127NME10.40141211
128PRKDC0.39614452
129RAF10.39449968
130BRD40.38889527
131MAP2K30.38459867
132MARK30.35667875
133MAP3K120.35625878
134MAP3K110.35503999
135CDK40.33876378
136CLK10.33279000
137GSK3B0.33251483
138MAPK140.32837471
139DYRK1A0.32642784
140AKT20.32169960
141CDK60.29321294
142CSNK2A20.28033988

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.86173482
2DNA replication_Homo sapiens_hsa030303.46982276
3RNA polymerase_Homo sapiens_hsa030203.40071671
4Homologous recombination_Homo sapiens_hsa034403.33625218
5Basal transcription factors_Homo sapiens_hsa030223.21587606
6Cell cycle_Homo sapiens_hsa041103.14584865
7Mismatch repair_Homo sapiens_hsa034303.01800201
8RNA transport_Homo sapiens_hsa030132.98348479
9Fanconi anemia pathway_Homo sapiens_hsa034602.98218893
10Spliceosome_Homo sapiens_hsa030402.55142212
11RNA degradation_Homo sapiens_hsa030182.45932213
12mRNA surveillance pathway_Homo sapiens_hsa030152.41259556
13Nucleotide excision repair_Homo sapiens_hsa034202.41241532
14Base excision repair_Homo sapiens_hsa034102.18536956
15Proteasome_Homo sapiens_hsa030502.08348869
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90527478
17Oocyte meiosis_Homo sapiens_hsa041141.88509854
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77990553
19Pyrimidine metabolism_Homo sapiens_hsa002401.72957727
20p53 signaling pathway_Homo sapiens_hsa041151.72766417
21Biosynthesis of amino acids_Homo sapiens_hsa012301.67036830
22Non-homologous end-joining_Homo sapiens_hsa034501.63165194
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63070091
24* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61676685
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50739296
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43743181
27One carbon pool by folate_Homo sapiens_hsa006701.37317315
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32101501
29Pyruvate metabolism_Homo sapiens_hsa006201.24551361
30Protein export_Homo sapiens_hsa030601.23669211
31Thyroid cancer_Homo sapiens_hsa052161.23311629
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22293715
33Carbon metabolism_Homo sapiens_hsa012001.21460381
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21379301
35TGF-beta signaling pathway_Homo sapiens_hsa043501.20475851
36Selenocompound metabolism_Homo sapiens_hsa004501.20195137
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18542414
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.17505762
39Purine metabolism_Homo sapiens_hsa002301.12532732
40Hippo signaling pathway_Homo sapiens_hsa043901.12055717
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11810482
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06868409
43Epstein-Barr virus infection_Homo sapiens_hsa051691.05584700
44MicroRNAs in cancer_Homo sapiens_hsa052061.04628060
45Ribosome_Homo sapiens_hsa030101.03722753
46Fatty acid elongation_Homo sapiens_hsa000621.02008536
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95542118
48Lysine degradation_Homo sapiens_hsa003100.91755971
49Wnt signaling pathway_Homo sapiens_hsa043100.91683683
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91517069
51Herpes simplex infection_Homo sapiens_hsa051680.87760081
52Colorectal cancer_Homo sapiens_hsa052100.87445637
53Vitamin B6 metabolism_Homo sapiens_hsa007500.87392057
54Nicotine addiction_Homo sapiens_hsa050330.86173747
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85325549
56Folate biosynthesis_Homo sapiens_hsa007900.83270212
57Steroid biosynthesis_Homo sapiens_hsa001000.80834741
58Pentose phosphate pathway_Homo sapiens_hsa000300.80339690
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80285306
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79493120
61Hedgehog signaling pathway_Homo sapiens_hsa043400.79419753
62Melanoma_Homo sapiens_hsa052180.78553682
63Endometrial cancer_Homo sapiens_hsa052130.77496506
64Adherens junction_Homo sapiens_hsa045200.75391476
65ErbB signaling pathway_Homo sapiens_hsa040120.73074298
66Basal cell carcinoma_Homo sapiens_hsa052170.72571441
67Arginine biosynthesis_Homo sapiens_hsa002200.68052125
68Long-term potentiation_Homo sapiens_hsa047200.67933184
69HTLV-I infection_Homo sapiens_hsa051660.67246097
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67027897
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66515550
72Circadian rhythm_Homo sapiens_hsa047100.65187300
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62457800
74Huntingtons disease_Homo sapiens_hsa050160.59083835
75Proteoglycans in cancer_Homo sapiens_hsa052050.57899080
76Arginine and proline metabolism_Homo sapiens_hsa003300.57644046
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57023747
78Long-term depression_Homo sapiens_hsa047300.56345958
79Dorso-ventral axis formation_Homo sapiens_hsa043200.56141062
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55373083
81Olfactory transduction_Homo sapiens_hsa047400.53864356
82Insulin signaling pathway_Homo sapiens_hsa049100.53359421
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52675932
84Fatty acid metabolism_Homo sapiens_hsa012120.52587804
85mTOR signaling pathway_Homo sapiens_hsa041500.51225402
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51104867
87Prostate cancer_Homo sapiens_hsa052150.48954901
88AMPK signaling pathway_Homo sapiens_hsa041520.48806590
89Glioma_Homo sapiens_hsa052140.48386430
90Propanoate metabolism_Homo sapiens_hsa006400.48176045
91FoxO signaling pathway_Homo sapiens_hsa040680.47538858
92Pancreatic cancer_Homo sapiens_hsa052120.47445161
93Tight junction_Homo sapiens_hsa045300.47094063
94GnRH signaling pathway_Homo sapiens_hsa049120.46054154
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45597875
96Viral carcinogenesis_Homo sapiens_hsa052030.44998091
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44862138
98Hepatitis B_Homo sapiens_hsa051610.43852178
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43388653
100Dopaminergic synapse_Homo sapiens_hsa047280.42952411
101Fatty acid biosynthesis_Homo sapiens_hsa000610.42003105
102Synaptic vesicle cycle_Homo sapiens_hsa047210.41971464
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41360466
104Prolactin signaling pathway_Homo sapiens_hsa049170.41257745
105Glucagon signaling pathway_Homo sapiens_hsa049220.41222401
106Ras signaling pathway_Homo sapiens_hsa040140.41090504
107Bladder cancer_Homo sapiens_hsa052190.41030857
108Pathways in cancer_Homo sapiens_hsa052000.39177176
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.39028832
110MAPK signaling pathway_Homo sapiens_hsa040100.36953970
111Non-small cell lung cancer_Homo sapiens_hsa052230.36210784
112Choline metabolism in cancer_Homo sapiens_hsa052310.35987854
113Amphetamine addiction_Homo sapiens_hsa050310.35983139
114Serotonergic synapse_Homo sapiens_hsa047260.35873585
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35086343
116Taste transduction_Homo sapiens_hsa047420.34684192
117Linoleic acid metabolism_Homo sapiens_hsa005910.34361150
118Ovarian steroidogenesis_Homo sapiens_hsa049130.33739907
119Estrogen signaling pathway_Homo sapiens_hsa049150.33647376
120Melanogenesis_Homo sapiens_hsa049160.31795083
121Type I diabetes mellitus_Homo sapiens_hsa049400.31326846
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31273242
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30821892
124Glutamatergic synapse_Homo sapiens_hsa047240.30537045
125Arachidonic acid metabolism_Homo sapiens_hsa005900.30376468
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29888222
127Axon guidance_Homo sapiens_hsa043600.25857235
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25778273
129Acute myeloid leukemia_Homo sapiens_hsa052210.24903551
130Small cell lung cancer_Homo sapiens_hsa052220.24556090
131Chronic myeloid leukemia_Homo sapiens_hsa052200.24214023
132Ether lipid metabolism_Homo sapiens_hsa005650.23438973
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23374514
134Renal cell carcinoma_Homo sapiens_hsa052110.23126056
135HIF-1 signaling pathway_Homo sapiens_hsa040660.23042735
136Shigellosis_Homo sapiens_hsa051310.22644980
137Gap junction_Homo sapiens_hsa045400.22268637
138Influenza A_Homo sapiens_hsa051640.21265678
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20867178
140Phototransduction_Homo sapiens_hsa047440.20575235
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20491503

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »