UBE2L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.05755319
2proteasome assembly (GO:0043248)5.00188992
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.77237537
4formation of translation preinitiation complex (GO:0001731)4.56547315
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.51802829
6maturation of SSU-rRNA (GO:0030490)4.48446034
7viral transcription (GO:0019083)4.43452611
8regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.41750440
9anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.39490557
10translational termination (GO:0006415)4.36791181
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.36689258
12negative regulation of ligase activity (GO:0051352)4.32696182
13negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.32696182
14respiratory electron transport chain (GO:0022904)4.31753007
15chaperone-mediated protein transport (GO:0072321)4.27673164
16DNA strand elongation involved in DNA replication (GO:0006271)4.27180359
17ribosomal large subunit biogenesis (GO:0042273)4.25679714
18electron transport chain (GO:0022900)4.20340714
19rRNA modification (GO:0000154)4.17737712
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.13736932
21oxidative phosphorylation (GO:0006119)4.06455181
22ribosomal small subunit biogenesis (GO:0042274)4.05898288
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.04751803
24regulation of mitochondrial translation (GO:0070129)4.03445357
25antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.03082912
26DNA strand elongation (GO:0022616)4.02685470
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.02461132
28translational elongation (GO:0006414)4.02146711
29translational initiation (GO:0006413)4.01324796
30purine nucleobase biosynthetic process (GO:0009113)4.00604441
31regulation of cellular amino acid metabolic process (GO:0006521)3.98955656
32telomere maintenance via semi-conservative replication (GO:0032201)3.96735369
33establishment of integrated proviral latency (GO:0075713)3.95604798
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.95512606
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.95512606
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.95231578
37nucleobase biosynthetic process (GO:0046112)3.95044415
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.91869896
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.91869896
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.91869896
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.88177554
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.88177554
43* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.87764902
44cotranslational protein targeting to membrane (GO:0006613)3.87496718
45protein targeting to ER (GO:0045047)3.85650891
46signal transduction involved in cell cycle checkpoint (GO:0072395)3.83995492
47protein targeting to mitochondrion (GO:0006626)3.82185878
48ribosome assembly (GO:0042255)3.75525438
49DNA replication checkpoint (GO:0000076)3.73119087
50* positive regulation of ligase activity (GO:0051351)3.69861554
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64243735
52protein localization to endoplasmic reticulum (GO:0070972)3.63973161
53telomere maintenance via recombination (GO:0000722)3.62054427
54cullin deneddylation (GO:0010388)3.59008393
55translation (GO:0006412)3.56441292
56ribonucleoprotein complex biogenesis (GO:0022613)3.56146456
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55182850
58viral life cycle (GO:0019058)3.52345715
59rRNA methylation (GO:0031167)3.51593509
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49236816
61cellular protein complex disassembly (GO:0043624)3.48926941
62spliceosomal snRNP assembly (GO:0000387)3.47469434
63protein complex biogenesis (GO:0070271)3.47182566
64mitochondrial respiratory chain complex assembly (GO:0033108)3.45678143
65DNA replication initiation (GO:0006270)3.44660022
66CENP-A containing nucleosome assembly (GO:0034080)3.43395207
67establishment of protein localization to mitochondrion (GO:0072655)3.43354982
68maturation of 5.8S rRNA (GO:0000460)3.42805541
69DNA unwinding involved in DNA replication (GO:0006268)3.41377922
70protein localization to mitochondrion (GO:0070585)3.41051162
71* regulation of ubiquitin-protein transferase activity (GO:0051438)3.40792894
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.39848556
73NADH dehydrogenase complex assembly (GO:0010257)3.39848556
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39848556
75mitotic recombination (GO:0006312)3.38921567
76G1/S transition of mitotic cell cycle (GO:0000082)3.38685518
77cell cycle G1/S phase transition (GO:0044843)3.38685518
78mitotic metaphase plate congression (GO:0007080)3.35311181
79positive regulation of cell cycle arrest (GO:0071158)3.34659502
80protein deneddylation (GO:0000338)3.31764158
81chromatin remodeling at centromere (GO:0031055)3.31534629
82* regulation of ligase activity (GO:0051340)3.27854438
83protein neddylation (GO:0045116)3.27327656
84antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.26961446
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26934430
86regulation of cellular amine metabolic process (GO:0033238)3.26436830
87DNA deamination (GO:0045006)3.24640447
88termination of RNA polymerase III transcription (GO:0006386)3.22989231
89transcription elongation from RNA polymerase III promoter (GO:0006385)3.22989231
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20487160
91protein localization to kinetochore (GO:0034501)3.20179670
927-methylguanosine mRNA capping (GO:0006370)3.19467221
93energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19184854
94ATP synthesis coupled proton transport (GO:0015986)3.19184854
95rRNA processing (GO:0006364)3.18117981
96DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.18048890
97ribosome biogenesis (GO:0042254)3.17174108
98DNA catabolic process, exonucleolytic (GO:0000738)3.17155880
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14774366
100nucleobase-containing small molecule interconversion (GO:0015949)3.14433868
101IMP biosynthetic process (GO:0006188)3.13627889
102tRNA aminoacylation for protein translation (GO:0006418)3.12404997
103RNA capping (GO:0036260)3.12114336
1047-methylguanosine RNA capping (GO:0009452)3.12114336
105folic acid-containing compound biosynthetic process (GO:0009396)3.11346579
106establishment of viral latency (GO:0019043)3.11182637
107spliceosomal complex assembly (GO:0000245)3.10932159
108mitotic sister chromatid segregation (GO:0000070)3.10863423
109tRNA aminoacylation (GO:0043039)3.09600643
110amino acid activation (GO:0043038)3.09600643
111pseudouridine synthesis (GO:0001522)3.09152270
112nucleotide-excision repair, DNA gap filling (GO:0006297)3.08685988
113ATP biosynthetic process (GO:0006754)3.08653380
114protein complex disassembly (GO:0043241)3.08222005
115negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.07876908
116purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.07642856
117purine nucleoside monophosphate biosynthetic process (GO:0009127)3.07642856
118rRNA metabolic process (GO:0016072)3.07144997
119respiratory chain complex IV assembly (GO:0008535)3.05628658
120transcription-coupled nucleotide-excision repair (GO:0006283)3.05390985
121viral mRNA export from host cell nucleus (GO:0046784)3.04213122
122deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03493023
123mitotic nuclear envelope disassembly (GO:0007077)3.01969396
124telomere maintenance via telomere lengthening (GO:0010833)3.00007117
125macromolecular complex disassembly (GO:0032984)2.99019105
126DNA replication-independent nucleosome organization (GO:0034724)2.95120027
127DNA replication-independent nucleosome assembly (GO:0006336)2.95120027
128kinetochore organization (GO:0051383)2.92414315
129signal transduction in response to DNA damage (GO:0042770)2.87640933
130cellular component biogenesis (GO:0044085)2.87614372
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87127073
132regulation of protein heterodimerization activity (GO:0043497)2.86012529
133negative regulation of protein ubiquitination (GO:0031397)2.85784812
134establishment of chromosome localization (GO:0051303)2.85616419
135regulation of cell cycle arrest (GO:0071156)2.84944380
136DNA replication-dependent nucleosome assembly (GO:0006335)2.83891750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40450154
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.25288907
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.08169186
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85966078
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.53558064
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.53216738
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.38822504
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.22269060
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11611422
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.99365199
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88705214
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84764281
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82789923
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68294276
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66883126
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63206378
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54960423
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46577395
19* XRN2_22483619_ChIP-Seq_HELA_Human2.45757299
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45038499
21* VDR_23849224_ChIP-Seq_CD4+_Human2.34704502
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31999568
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31671327
24DCP1A_22483619_ChIP-Seq_HELA_Human2.25018377
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12953314
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12557030
27ELK1_19687146_ChIP-ChIP_HELA_Human1.99958033
28FOXP3_21729870_ChIP-Seq_TREG_Human1.99350512
29GABP_19822575_ChIP-Seq_HepG2_Human1.97865897
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92710834
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90463378
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88657717
33TTF2_22483619_ChIP-Seq_HELA_Human1.87726183
34AR_21909140_ChIP-Seq_LNCAP_Human1.85909428
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80446349
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77557141
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69218547
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.66968626
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66936512
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65396454
41* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65359993
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.64805619
43* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62786257
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60994546
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60528494
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60178441
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.54424745
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53328776
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.49006625
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48558184
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44382339
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44123798
53KDM5A_27292631_Chip-Seq_BREAST_Human1.42387148
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41683511
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40512853
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.39383496
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38790641
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35565539
59* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33787988
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.32559086
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27476084
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26223130
63TFEB_21752829_ChIP-Seq_HELA_Human1.25900324
64SPI1_23547873_ChIP-Seq_NB4_Human1.25579415
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24351517
66CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20453569
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20222357
68CIITA_25753668_ChIP-Seq_RAJI_Human1.15998196
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15137171
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13605975
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13251432
72MYC_22102868_ChIP-Seq_BL_Human1.13072175
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12945067
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11717886
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06788612
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05056343
77ZNF263_19887448_ChIP-Seq_K562_Human1.04647880
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04489866
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.04232961
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04125275
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03026621
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02990346
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02432672
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02288078
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00705910
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98800820
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97810942
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97411772
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97231235
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96960669
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94981325
92OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94086201
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93724462
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91461876
95BP1_19119308_ChIP-ChIP_Hs578T_Human0.91335623
96MYC_18940864_ChIP-ChIP_HL60_Human0.90177720
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89120427
98* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88578489
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88249995
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.87305538
101* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87257845
102VDR_21846776_ChIP-Seq_THP-1_Human0.85405960
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85222702
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83898892
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83537393
106MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83422708
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79931030
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77883464
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76643462
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75334010
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75253468
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74721706
113* NCOR1_26117541_ChIP-Seq_K562_Human0.74068834
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.72080057
115SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71013179
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70512326
117* ELF5_23300383_ChIP-Seq_T47D_Human0.68783736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.33736031
2MP0004957_abnormal_blastocyst_morpholog4.23677552
3MP0003111_abnormal_nucleus_morphology3.54649873
4MP0003077_abnormal_cell_cycle3.50822987
5MP0010094_abnormal_chromosome_stability3.50020011
6MP0009697_abnormal_copulation3.37844950
7MP0008057_abnormal_DNA_replication2.84193389
8MP0003123_paternal_imprinting2.73782035
9MP0008007_abnormal_cellular_replicative2.72075366
10MP0004147_increased_porphyrin_level2.71945357
11MP0008932_abnormal_embryonic_tissue2.64804504
12MP0003186_abnormal_redox_activity2.21694040
13MP0008058_abnormal_DNA_repair2.18666144
14MP0010352_gastrointestinal_tract_polyps2.12473219
15MP0001730_embryonic_growth_arrest2.10635640
16MP0002396_abnormal_hematopoietic_system2.10268454
17MP0009333_abnormal_splenocyte_physiolog1.95575523
18MP0000350_abnormal_cell_proliferation1.95332567
19MP0003941_abnormal_skin_development1.77439646
20MP0001835_abnormal_antigen_presentation1.76515947
21MP0010030_abnormal_orbit_morphology1.74336800
22MP0008995_early_reproductive_senescence1.73315679
23MP0000490_abnormal_crypts_of1.67747926
24MP0002148_abnormal_hypersensitivity_rea1.64930070
25MP0003806_abnormal_nucleotide_metabolis1.61656433
26MP0003436_decreased_susceptibility_to1.56426428
27MP0001697_abnormal_embryo_size1.54446228
28MP0005058_abnormal_lysosome_morphology1.50174276
29MP0009785_altered_susceptibility_to1.48281580
30MP0006054_spinal_hemorrhage1.44960830
31MP0000313_abnormal_cell_death1.42947283
32MP0000858_altered_metastatic_potential1.42772161
33MP0003315_abnormal_perineum_morphology1.38553130
34* MP0002080_prenatal_lethality1.36918618
35MP0006292_abnormal_olfactory_placode1.35352533
36MP0000678_abnormal_parathyroid_gland1.32835096
37MP0004808_abnormal_hematopoietic_stem1.31189323
38MP0001529_abnormal_vocalization1.30640832
39MP0010307_abnormal_tumor_latency1.29745737
40MP0003221_abnormal_cardiomyocyte_apopto1.28759399
41MP0003567_abnormal_fetal_cardiomyocyte1.28396500
42MP0003786_premature_aging1.27787678
43MP0003705_abnormal_hypodermis_morpholog1.25810101
44MP0003718_maternal_effect1.24959666
45MP0005000_abnormal_immune_tolerance1.24816609
46MP0001764_abnormal_homeostasis1.24470960
47MP0001853_heart_inflammation1.23681270
48MP0009379_abnormal_foot_pigmentation1.23667519
49MP0002398_abnormal_bone_marrow1.23561458
50* MP0005380_embryogenesis_phenotype1.23409993
51* MP0001672_abnormal_embryogenesis/_devel1.23409993
52MP0006036_abnormal_mitochondrial_physio1.23169221
53* MP0003984_embryonic_growth_retardation1.23131276
54MP0001545_abnormal_hematopoietic_system1.22776885
55MP0005397_hematopoietic_system_phenotyp1.22776885
56MP0000750_abnormal_muscle_regeneration1.22202725
57MP0000358_abnormal_cell_content/1.21268897
58* MP0002088_abnormal_embryonic_growth/wei1.19089433
59MP0002452_abnormal_antigen_presenting1.18505482
60MP0000343_altered_response_to1.18485109
61MP0005025_abnormal_response_to1.17897907
62MP0002019_abnormal_tumor_incidence1.17407881
63MP0003448_altered_tumor_morphology1.16515045
64MP0002419_abnormal_innate_immunity1.14610479
65MP0005410_abnormal_fertilization1.14304838
66MP0005671_abnormal_response_to1.13715930
67MP0002722_abnormal_immune_system1.13604515
68MP0001929_abnormal_gametogenesis1.11851686
69MP0002163_abnormal_gland_morphology1.11548348
70MP0009053_abnormal_anal_canal1.11397943
71MP0003950_abnormal_plasma_membrane1.10061354
72MP0004197_abnormal_fetal_growth/weight/1.09653417
73MP0002429_abnormal_blood_cell1.08802226
74MP0001819_abnormal_immune_cell1.08382301
75MP0005636_abnormal_mineral_homeostasis1.08301093
76MP0002210_abnormal_sex_determination1.07395626
77MP0002420_abnormal_adaptive_immunity1.06556353
78MP0000689_abnormal_spleen_morphology1.05541482
79MP0008789_abnormal_olfactory_epithelium1.04644249
80MP0001661_extended_life_span1.04542469
81MP0001542_abnormal_bone_strength1.03213660
82MP0002405_respiratory_system_inflammati1.02487382
83MP0001881_abnormal_mammary_gland1.00709699
84MP0006082_CNS_inflammation1.00504360
85MP0000537_abnormal_urethra_morphology1.00457706
86MP0000716_abnormal_immune_system1.00416180
87MP0000703_abnormal_thymus_morphology0.98845043
88MP0002723_abnormal_immune_serum0.96453362
89MP0002085_abnormal_embryonic_tissue0.96444520
90MP0003303_peritoneal_inflammation0.95612305
91MP0005084_abnormal_gallbladder_morpholo0.94666599
92MP0006035_abnormal_mitochondrial_morpho0.92582073
93* MP0002086_abnormal_extraembryonic_tissu0.92041481
94MP0001905_abnormal_dopamine_level0.91702653
95MP0001727_abnormal_embryo_implantation0.90537763
96MP0001800_abnormal_humoral_immune0.90304000
97MP0002160_abnormal_reproductive_system0.84454361
98MP0005023_abnormal_wound_healing0.84412124
99MP0000685_abnormal_immune_system0.83167871
100MP0002736_abnormal_nociception_after0.82247725
101MP0003656_abnormal_erythrocyte_physiolo0.80730977
102MP0004233_abnormal_muscle_weight0.80721117
103MP0005395_other_phenotype0.80379523
104MP0001145_abnormal_male_reproductive0.79830749
105MP0001533_abnormal_skeleton_physiology0.79628420
106MP0000653_abnormal_sex_gland0.78681945
107MP0005332_abnormal_amino_acid0.78317295
108MP0008438_abnormal_cutaneous_collagen0.78257969
109MP0001293_anophthalmia0.77851994
110MP0002938_white_spotting0.77118247
111MP0005384_cellular_phenotype0.75949493
112MP0005330_cardiomyopathy0.75894477
113MP0009672_abnormal_birth_weight0.75384380
114MP0005501_abnormal_skin_physiology0.74389705
115MP0002277_abnormal_respiratory_mucosa0.73701940
116MP0002132_abnormal_respiratory_system0.72727559
117MP0005408_hypopigmentation0.72283629
118MP0000733_abnormal_muscle_development0.71990368
119MP0006072_abnormal_retinal_apoptosis0.71597626
120MP0000372_irregular_coat_pigmentation0.70534253
121MP0008877_abnormal_DNA_methylation0.70506027
122MP0001845_abnormal_inflammatory_respons0.69335985
123MP0000749_muscle_degeneration0.69211788
124MP0004084_abnormal_cardiac_muscle0.69071119
125MP0005083_abnormal_biliary_tract0.68507782
126MP0002084_abnormal_developmental_patter0.68337287
127MP0003763_abnormal_thymus_physiology0.68172426
128MP0010155_abnormal_intestine_physiology0.67340918
129MP0001790_abnormal_immune_system0.66214524
130MP0005387_immune_system_phenotype0.66214524
131MP0008872_abnormal_physiological_respon0.64579222
132MP0003121_genomic_imprinting0.64539893
133MP0008873_increased_physiological_sensi0.63518037
134MP0004215_abnormal_myocardial_fiber0.61627483
135MP0001119_abnormal_female_reproductive0.61309129
136MP0008875_abnormal_xenobiotic_pharmacok0.61180267
137MP0002837_dystrophic_cardiac_calcinosis0.56893992
138MP0002102_abnormal_ear_morphology0.56057534
139MP0002161_abnormal_fertility/fecundity0.55291848
140MP0005499_abnormal_olfactory_system0.54960387
141MP0005394_taste/olfaction_phenotype0.54960387
142MP0002269_muscular_atrophy0.53885969
143MP0003698_abnormal_male_reproductive0.53531179
144MP0002090_abnormal_vision0.52960907
145MP0005464_abnormal_platelet_physiology0.52876884
146MP0004019_abnormal_vitamin_homeostasis0.52287758
147MP0005319_abnormal_enzyme/_coenzyme0.51958363
148MP0002111_abnormal_tail_morphology0.50773168
149MP0005389_reproductive_system_phenotype0.49131605
150MP0002095_abnormal_skin_pigmentation0.48502456

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.81185044
2Abnormal number of erythroid precursors (HP:0012131)4.43865574
3Reticulocytopenia (HP:0001896)4.23958790
4Abnormality of the anterior horn cell (HP:0006802)3.95763924
5Degeneration of anterior horn cells (HP:0002398)3.95763924
6Cerebral edema (HP:0002181)3.74969942
7Multiple enchondromatosis (HP:0005701)3.74561306
8Cerebral hypomyelination (HP:0006808)3.62749180
9Abnormal gallbladder physiology (HP:0012438)3.62578744
10Cholecystitis (HP:0001082)3.62578744
11Macrocytic anemia (HP:0001972)3.44029328
12Birth length less than 3rd percentile (HP:0003561)3.34922466
13Type I transferrin isoform profile (HP:0003642)3.25345140
14Abnormality of glycolysis (HP:0004366)3.22041346
15Increased serum pyruvate (HP:0003542)3.22041346
16Poor head control (HP:0002421)3.21119369
17Lactic acidosis (HP:0003128)3.20223044
18Truncus arteriosus (HP:0001660)3.19210665
19Increased intramyocellular lipid droplets (HP:0012240)3.16259219
20Acute necrotizing encephalopathy (HP:0006965)3.09108479
21Rough bone trabeculation (HP:0100670)3.06469771
22Breast hypoplasia (HP:0003187)3.04513325
23Mitochondrial inheritance (HP:0001427)3.04509778
24Carpal bone hypoplasia (HP:0001498)3.00528409
25Pallor (HP:0000980)2.90924704
26Agnosia (HP:0010524)2.89804914
27Trismus (HP:0000211)2.85240971
28Oral leukoplakia (HP:0002745)2.84207114
29Hyperthyroidism (HP:0000836)2.81394368
30Increased CSF lactate (HP:0002490)2.79375491
31Recurrent abscess formation (HP:0002722)2.78155871
32Increased hepatocellular lipid droplets (HP:0006565)2.77989151
33Abnormal mitochondria in muscle tissue (HP:0008316)2.75599856
34Hepatocellular necrosis (HP:0001404)2.75569238
35Colon cancer (HP:0003003)2.73690695
36Exertional dyspnea (HP:0002875)2.72897875
37Patellar aplasia (HP:0006443)2.71037802
38Increased muscle lipid content (HP:0009058)2.68869200
39Aplasia/Hypoplasia of the patella (HP:0006498)2.67507963
40Leukodystrophy (HP:0002415)2.65163588
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62561172
42Abnormality of methionine metabolism (HP:0010901)2.58638557
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58106895
44Abnormal protein N-linked glycosylation (HP:0012347)2.58106895
45Abnormal protein glycosylation (HP:0012346)2.58106895
46Abnormal glycosylation (HP:0012345)2.58106895
47Hepatic necrosis (HP:0002605)2.55716905
48Lipid accumulation in hepatocytes (HP:0006561)2.48001165
49Progressive macrocephaly (HP:0004481)2.46319766
50Pancytopenia (HP:0001876)2.45652748
51Lethargy (HP:0001254)2.41147075
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39547658
53Acute encephalopathy (HP:0006846)2.37717924
54Abnormality of the umbilical cord (HP:0010881)2.34873202
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34252122
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34252122
57Chromsome breakage (HP:0040012)2.32911085
58Hypertensive crisis (HP:0100735)2.32821666
59Respiratory failure (HP:0002878)2.32640786
60Abnormal trabecular bone morphology (HP:0100671)2.32035780
61Nausea (HP:0002018)2.31189541
62Recurrent bacterial skin infections (HP:0005406)2.31112458
63Reduced antithrombin III activity (HP:0001976)2.30781430
64Increased serum lactate (HP:0002151)2.26701337
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26134176
66Premature graying of hair (HP:0002216)2.24371211
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.23692343
68Seborrheic dermatitis (HP:0001051)2.23664747
69Emotional lability (HP:0000712)2.23499484
70Exercise intolerance (HP:0003546)2.21927040
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20662889
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.17656752
73Cleft eyelid (HP:0000625)2.17227093
74Short middle phalanx of the 5th finger (HP:0004220)2.15966513
75Abnormality of the preputium (HP:0100587)2.15650490
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15602607
77Abnormality of alanine metabolism (HP:0010916)2.15602607
78Hyperalaninemia (HP:0003348)2.15602607
79Aplastic anemia (HP:0001915)2.14324029
80Abnormality of homocysteine metabolism (HP:0010919)2.14322247
81Homocystinuria (HP:0002156)2.14322247
82Petechiae (HP:0000967)2.12956958
83Optic disc pallor (HP:0000543)2.12930781
84Palpitations (HP:0001962)2.11263466
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09988637
86Neoplasm of the pancreas (HP:0002894)2.09808136
87Methylmalonic acidemia (HP:0002912)2.07598230
88Methylmalonic aciduria (HP:0012120)2.05703335
89Abnormality of reticulocytes (HP:0004312)2.04634964
90Abnormal hemoglobin (HP:0011902)2.02932803
91Secondary amenorrhea (HP:0000869)2.00812175
92Abnormality of the ileum (HP:0001549)2.00772866
93Personality changes (HP:0000751)1.99712238
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99664785
95Nemaline bodies (HP:0003798)1.98772375
96Small intestinal stenosis (HP:0012848)1.98050564
97Duodenal stenosis (HP:0100867)1.98050564
98Postnatal microcephaly (HP:0005484)1.97557411
99Generalized aminoaciduria (HP:0002909)1.96311095
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96052287
101Premature ovarian failure (HP:0008209)1.94881506
102Respiratory difficulties (HP:0002880)1.94795855
103Adenoma sebaceum (HP:0009720)1.92856657
104Angiofibromas (HP:0010615)1.92856657
105Hepatosplenomegaly (HP:0001433)1.92842358
106Atresia of the external auditory canal (HP:0000413)1.92384688
107Progressive muscle weakness (HP:0003323)1.92214498
108Abnormality of serum amino acid levels (HP:0003112)1.91877535
109Abnormality of the tricuspid valve (HP:0001702)1.91229999
110Abnormalities of placenta or umbilical cord (HP:0001194)1.90306124
111X-linked dominant inheritance (HP:0001423)1.89770899
112Thrombocytosis (HP:0001894)1.89389069
113Glossoptosis (HP:0000162)1.89376384
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.89190176
115Microretrognathia (HP:0000308)1.89025371
116Aplasia/Hypoplasia of the uvula (HP:0010293)1.88576334
117Eczematoid dermatitis (HP:0000976)1.86669127
118CNS demyelination (HP:0007305)1.86492588
119Selective tooth agenesis (HP:0001592)1.86258283
120Calcaneovalgus deformity (HP:0001848)1.86229091
121Redundant skin (HP:0001582)1.85518293
122Testicular atrophy (HP:0000029)1.85251311
123Abnormality of renal resorption (HP:0011038)1.84468180
124Horseshoe kidney (HP:0000085)1.81451225
125Abnormal lung lobation (HP:0002101)1.80998378
126Abnormality of macrophages (HP:0004311)1.80800145
127Congenital ichthyosiform erythroderma (HP:0007431)1.80750634
128Renal Fanconi syndrome (HP:0001994)1.80631235
129Mucosal telangiectasiae (HP:0100579)1.80450171
130Vertebral compression fractures (HP:0002953)1.79530728
131Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77770908
132Meckel diverticulum (HP:0002245)1.77643251
133Abnormality of placental membranes (HP:0011409)1.76838297
134Amniotic constriction ring (HP:0009775)1.76838297
135Chronic obstructive pulmonary disease (HP:0006510)1.76452787
136Obstructive lung disease (HP:0006536)1.76452787
137Elevated erythrocyte sedimentation rate (HP:0003565)1.76352584
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75204986
139Abnormality of the calcaneus (HP:0008364)1.74192629
1403-Methylglutaconic aciduria (HP:0003535)1.74031573
141Microvesicular hepatic steatosis (HP:0001414)1.73694798
14211 pairs of ribs (HP:0000878)1.73313153
143Basal ganglia calcification (HP:0002135)1.73194626
144Irregular epiphyses (HP:0010582)1.73034542
145Sparse eyelashes (HP:0000653)1.71281757
146CNS hypomyelination (HP:0003429)1.70420724
147Bone marrow hypocellularity (HP:0005528)1.70417104
148Deformed tarsal bones (HP:0008119)1.70308681
149Slender long bone (HP:0003100)1.70072778
150Vacuolated lymphocytes (HP:0001922)1.69896550
151Neoplasm of the adrenal gland (HP:0100631)1.68656675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.18151119
2EIF2AK14.77914965
3VRK23.50045140
4WEE13.29459851
5PBK3.24595577
6NME23.09305518
7CDC72.59710654
8TESK22.46178625
9PIM22.44691834
10SRPK12.40042244
11BRSK22.17555892
12TLK12.14999669
13NEK12.09685552
14MAP3K122.07978647
15TESK12.04676676
16EIF2AK32.02814230
17LIMK12.01200398
18MKNK11.80266559
19PLK41.78792816
20PDK21.75401990
21TSSK61.68401224
22STK161.64863834
23BRSK11.60382582
24NEK91.59708101
25MST41.53597738
26LRRK21.52058830
27RPS6KA41.43408249
28VRK11.40438502
29PLK11.38458945
30ILK1.37066361
31TRIM281.30539111
32PLK31.30095314
33SCYL21.27083033
34PAK41.26001104
35NME11.21377893
36KDR1.19945588
37ABL21.17817117
38AURKB1.17645729
39AURKA1.17191172
40STK41.15128611
41BCKDK1.11687918
42MAP3K81.11198471
43ACVR1B1.05877304
44NEK21.04927756
45MKNK21.00122633
46CDK70.98551149
47DAPK10.96985541
48NUAK10.95838164
49RPS6KB20.95502806
50TTK0.93891987
51PAK10.93015741
52ERBB30.92298241
53DYRK30.92117807
54RAF10.91534899
55STK100.91365763
56CDK80.88311124
57BMPR20.87682881
58IRAK40.87437884
59ARAF0.87391074
60EIF2AK20.80945085
61MAP3K110.80676970
62IRAK30.78432633
63PIM10.76474937
64ATR0.76052415
65BLK0.75877867
66STK240.74758057
67ALK0.73445338
68CLK10.72107798
69CSNK2A10.70321989
70CSNK1G30.68974283
71TGFBR10.67746433
72MAP4K20.67637855
73ZAK0.67041087
74DYRK20.65477520
75PLK20.64771936
76BCR0.64577932
77MAPKAPK30.64443202
78TBK10.64091999
79CHEK10.63336205
80CSNK2A20.59095861
81MAP4K10.58603668
82KSR20.58279677
83CDK190.54818804
84CDK40.54200688
85PKN20.52950081
86CCNB10.50743181
87IKBKB0.47920191
88RIPK40.47832902
89CHEK20.47648935
90RPS6KA50.47552700
91TYK20.46442942
92CSNK1A1L0.46285383
93CDK140.45866887
94DAPK30.45770219
95CSNK1G10.45689618
96PASK0.45377088
97MAPKAPK20.45191339
98EPHA20.45001453
99CDK20.44845148
100BTK0.43924583
101TRIB30.42447753
102MAP3K20.40779586
103BRAF0.40741201
104BMPR1B0.38738205
105MAPKAPK50.37194359
106RPS6KA60.37052805
107RPS6KL10.35876039
108RPS6KC10.35876039
109MINK10.34764722
110PAK20.34198281
111CSNK1E0.34142165
112CDK180.33689079
113CDK11A0.33571810
114MAP2K30.33520292
115ERBB40.33009638
116MARK30.32867941
117KIT0.32572157
118LYN0.32315149
119PRKCI0.31284960
120CSNK1G20.30547008
121OBSCN0.30188088
122CDK150.29989600
123WNK40.29451113
124MYLK0.29068181
125JAK30.28505064
126AKT20.28487655
127TAOK20.28048023
128STK30.27663341
129ATM0.27480612
130CDK10.27431464

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.34195678
2Ribosome_Homo sapiens_hsa030104.28719239
3DNA replication_Homo sapiens_hsa030304.13773402
4Mismatch repair_Homo sapiens_hsa034303.35010307
5RNA polymerase_Homo sapiens_hsa030203.26259912
6Spliceosome_Homo sapiens_hsa030402.97991150
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86525195
8RNA transport_Homo sapiens_hsa030132.50153495
9Base excision repair_Homo sapiens_hsa034102.42552557
10Nucleotide excision repair_Homo sapiens_hsa034202.31014013
11Pyrimidine metabolism_Homo sapiens_hsa002402.30869690
12Homologous recombination_Homo sapiens_hsa034402.23280719
13Cell cycle_Homo sapiens_hsa041102.07622596
14Oxidative phosphorylation_Homo sapiens_hsa001902.05776596
15Parkinsons disease_Homo sapiens_hsa050122.00809419
16One carbon pool by folate_Homo sapiens_hsa006701.71797273
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71231337
18Protein export_Homo sapiens_hsa030601.60994062
19Fatty acid elongation_Homo sapiens_hsa000621.59423592
20Huntingtons disease_Homo sapiens_hsa050161.56427430
21Epstein-Barr virus infection_Homo sapiens_hsa051691.46584955
22Pyruvate metabolism_Homo sapiens_hsa006201.44195991
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40291348
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39786085
25RNA degradation_Homo sapiens_hsa030181.35270109
26Basal transcription factors_Homo sapiens_hsa030221.28309939
27Legionellosis_Homo sapiens_hsa051341.27573025
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22067385
29p53 signaling pathway_Homo sapiens_hsa041151.13439452
30Antigen processing and presentation_Homo sapiens_hsa046121.12710600
31Sulfur metabolism_Homo sapiens_hsa009201.12086559
32Alzheimers disease_Homo sapiens_hsa050101.11256138
33Non-homologous end-joining_Homo sapiens_hsa034501.10742320
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10643941
35Propanoate metabolism_Homo sapiens_hsa006401.06869268
36Shigellosis_Homo sapiens_hsa051311.04730688
37Purine metabolism_Homo sapiens_hsa002301.04616982
38Fanconi anemia pathway_Homo sapiens_hsa034601.03101416
39mRNA surveillance pathway_Homo sapiens_hsa030151.00553977
40Pentose phosphate pathway_Homo sapiens_hsa000300.97545504
41Sulfur relay system_Homo sapiens_hsa041220.92282844
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85288342
43Graft-versus-host disease_Homo sapiens_hsa053320.84830288
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84798907
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82663024
46Herpes simplex infection_Homo sapiens_hsa051680.80567672
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74259578
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73496331
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72086988
50Glutathione metabolism_Homo sapiens_hsa004800.71656028
51Oocyte meiosis_Homo sapiens_hsa041140.70740326
52Viral carcinogenesis_Homo sapiens_hsa052030.69332210
53Selenocompound metabolism_Homo sapiens_hsa004500.69155412
54Folate biosynthesis_Homo sapiens_hsa007900.69132989
55Apoptosis_Homo sapiens_hsa042100.68390755
56Leishmaniasis_Homo sapiens_hsa051400.67777210
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67681077
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67297184
59Allograft rejection_Homo sapiens_hsa053300.66519976
60Carbon metabolism_Homo sapiens_hsa012000.64953499
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64566959
62Vitamin B6 metabolism_Homo sapiens_hsa007500.64500111
63Thyroid cancer_Homo sapiens_hsa052160.64471853
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64216159
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63394787
66N-Glycan biosynthesis_Homo sapiens_hsa005100.63048495
67Biosynthesis of amino acids_Homo sapiens_hsa012300.61726555
68Phagosome_Homo sapiens_hsa041450.60684128
69Collecting duct acid secretion_Homo sapiens_hsa049660.58784389
70Pertussis_Homo sapiens_hsa051330.58237784
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57645913
72Measles_Homo sapiens_hsa051620.56888142
73Viral myocarditis_Homo sapiens_hsa054160.55312620
74HTLV-I infection_Homo sapiens_hsa051660.55256271
75* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54745087
76Salmonella infection_Homo sapiens_hsa051320.53602712
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.52612585
78Lysosome_Homo sapiens_hsa041420.51682625
79Asthma_Homo sapiens_hsa053100.51262658
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50823362
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50179997
82Fructose and mannose metabolism_Homo sapiens_hsa000510.49675849
83Cardiac muscle contraction_Homo sapiens_hsa042600.48548261
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.47840967
85Tuberculosis_Homo sapiens_hsa051520.47669023
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47529268
87Fatty acid metabolism_Homo sapiens_hsa012120.43676920
88Butanoate metabolism_Homo sapiens_hsa006500.43266272
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.42821944
90Vibrio cholerae infection_Homo sapiens_hsa051100.42765411
91Peroxisome_Homo sapiens_hsa041460.41376701
92Rheumatoid arthritis_Homo sapiens_hsa053230.39979209
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.37722944
94Influenza A_Homo sapiens_hsa051640.37450560
95Type I diabetes mellitus_Homo sapiens_hsa049400.37158689
96Arginine and proline metabolism_Homo sapiens_hsa003300.35645961
97Hepatitis B_Homo sapiens_hsa051610.35114282
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35037558
99HIF-1 signaling pathway_Homo sapiens_hsa040660.34963454
100Malaria_Homo sapiens_hsa051440.33975711
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33826708
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.32685211
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32580152
104Tyrosine metabolism_Homo sapiens_hsa003500.29577579
105Galactose metabolism_Homo sapiens_hsa000520.29408198
106Chronic myeloid leukemia_Homo sapiens_hsa052200.29310417
107Systemic lupus erythematosus_Homo sapiens_hsa053220.27831224
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27076005
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26981723
110Primary immunodeficiency_Homo sapiens_hsa053400.26336767
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25329548
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24708081
113Acute myeloid leukemia_Homo sapiens_hsa052210.24005067
114Metabolic pathways_Homo sapiens_hsa011000.23471581
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23309527
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23060852
117Small cell lung cancer_Homo sapiens_hsa052220.22478927
118Regulation of autophagy_Homo sapiens_hsa041400.21699763
119Colorectal cancer_Homo sapiens_hsa052100.21216134
120Bladder cancer_Homo sapiens_hsa052190.21154313
121Steroid biosynthesis_Homo sapiens_hsa001000.21057515
122Hematopoietic cell lineage_Homo sapiens_hsa046400.20935935
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19800697
124Arginine biosynthesis_Homo sapiens_hsa002200.18765674
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16606272
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13093007
127Mineral absorption_Homo sapiens_hsa049780.07802448
128Chemical carcinogenesis_Homo sapiens_hsa052040.06924289
129beta-Alanine metabolism_Homo sapiens_hsa004100.06116378
130Phenylalanine metabolism_Homo sapiens_hsa003600.05894316
131Fatty acid degradation_Homo sapiens_hsa000710.05641749
132Olfactory transduction_Homo sapiens_hsa047400.05065454
133Fat digestion and absorption_Homo sapiens_hsa049750.04261346
134Synaptic vesicle cycle_Homo sapiens_hsa047210.03153299
135Vitamin digestion and absorption_Homo sapiens_hsa049770.02067656
136Nitrogen metabolism_Homo sapiens_hsa00910-0.0055607
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0052848

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