UBE2L6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.44872658
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.39309288
3protoporphyrinogen IX biosynthetic process (GO:0006782)4.96265896
4negative regulation of cell killing (GO:0031342)4.55485912
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55485912
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54088621
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54088621
8response to type I interferon (GO:0034340)4.48929853
9type I interferon signaling pathway (GO:0060337)4.48078160
10cellular response to type I interferon (GO:0071357)4.48078160
11antigen processing and presentation of endogenous antigen (GO:0019883)4.40534319
12heme biosynthetic process (GO:0006783)4.32971147
13response to interferon-beta (GO:0035456)4.30653351
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22343119
15response to interferon-alpha (GO:0035455)4.14437694
16regulation of B cell receptor signaling pathway (GO:0050855)4.11071993
17heme metabolic process (GO:0042168)4.01729561
18positive regulation of interferon-alpha production (GO:0032727)4.00998147
19negative regulation of viral genome replication (GO:0045071)3.93985637
20porphyrin-containing compound biosynthetic process (GO:0006779)3.90815337
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.86057228
22T cell migration (GO:0072678)3.78789142
23regulation of interferon-alpha production (GO:0032647)3.76027282
24detection of bacterium (GO:0016045)3.73910736
25detection of other organism (GO:0098543)3.64012796
26porphyrin-containing compound metabolic process (GO:0006778)3.62404150
27immunoglobulin mediated immune response (GO:0016064)3.61316548
28negative T cell selection (GO:0043383)3.55855747
29regulation of RIG-I signaling pathway (GO:0039535)3.53991893
30cellular response to interferon-beta (GO:0035458)3.53783183
31positive thymic T cell selection (GO:0045059)3.53686868
32cytidine metabolic process (GO:0046087)3.52747091
33cytidine catabolic process (GO:0006216)3.52747091
34cytidine deamination (GO:0009972)3.52747091
35tetrapyrrole biosynthetic process (GO:0033014)3.51227310
36negative thymic T cell selection (GO:0045060)3.51006790
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50610885
38regulation of T cell tolerance induction (GO:0002664)3.50047772
39negative regulation of interleukin-12 production (GO:0032695)3.43931530
40defense response to protozoan (GO:0042832)3.39038105
41neutrophil activation involved in immune response (GO:0002283)3.38915024
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38292634
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.38292634
44modulation by symbiont of host immune response (GO:0052553)3.38292634
45positive regulation by symbiont of host defense response (GO:0052509)3.38292634
46modulation by symbiont of host defense response (GO:0052031)3.38292634
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38292634
48regulation of regulatory T cell differentiation (GO:0045589)3.35395739
49T-helper 1 type immune response (GO:0042088)3.34602249
50regulation of gamma-delta T cell activation (GO:0046643)3.34599177
51negative regulation of innate immune response (GO:0045824)3.24198446
52cellular response to interleukin-15 (GO:0071350)3.23134779
53response to interleukin-15 (GO:0070672)3.22039184
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20356222
55B cell mediated immunity (GO:0019724)3.19387646
56positive regulation of natural killer cell differentiation (GO:0032825)3.19043922
57regulation of T cell mediated cytotoxicity (GO:0001914)3.18458926
58cellular response to virus (GO:0098586)3.17700134
59regulation of activation of Janus kinase activity (GO:0010533)3.16227419
60leukocyte aggregation (GO:0070486)3.15654661
61interferon-gamma-mediated signaling pathway (GO:0060333)3.14055769
62regulation of tolerance induction (GO:0002643)3.12732006
63DNA deamination (GO:0045006)3.12626262
64pyrimidine ribonucleoside catabolic process (GO:0046133)3.10624905
65positive regulation of antigen processing and presentation (GO:0002579)3.07371423
66negative regulation of lymphocyte mediated immunity (GO:0002707)3.05996141
67positive regulation of interferon-beta production (GO:0032728)3.04343452
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04026182
69response to peptidoglycan (GO:0032494)3.03544715
70regulation of B cell differentiation (GO:0045577)3.02555474
71positive regulation of type 2 immune response (GO:0002830)3.01846772
72positive T cell selection (GO:0043368)2.99425376
73regulation of gamma-delta T cell differentiation (GO:0045586)2.98477716
74regulation of natural killer cell mediated immunity (GO:0002715)2.98338766
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98338766
76negative regulation of leukocyte mediated immunity (GO:0002704)2.97761765
77cellular response to exogenous dsRNA (GO:0071360)2.97066729
78regulation of T-helper 1 cell differentiation (GO:0045625)2.95852232
79negative regulation of nitric oxide biosynthetic process (GO:0045019)2.95700286
80regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.93135265
81macrophage activation involved in immune response (GO:0002281)2.93050355
82lymphocyte chemotaxis (GO:0048247)2.92744875
83erythrocyte maturation (GO:0043249)2.91656274
84response to protozoan (GO:0001562)2.90177228
85NAD biosynthetic process (GO:0009435)2.89427800
86response to host immune response (GO:0052572)2.88775966
87response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88775966
88regulation of interleukin-2 biosynthetic process (GO:0045076)2.88581518
89positive regulation of tolerance induction (GO:0002645)2.88153399
90respiratory burst (GO:0045730)2.86340610
91detection of external biotic stimulus (GO:0098581)2.85592476
92regulation of interferon-beta biosynthetic process (GO:0045357)2.84577410
93regulation of leukocyte mediated cytotoxicity (GO:0001910)2.83987297
94mast cell activation (GO:0045576)2.83053117
95regulation of antigen processing and presentation (GO:0002577)2.82300706
96myeloid cell activation involved in immune response (GO:0002275)2.81743577
97thymic T cell selection (GO:0045061)2.81369901
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81345286
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.79920964
100B cell receptor signaling pathway (GO:0050853)2.78912332
101negative regulation of T cell mediated immunity (GO:0002710)2.78300670
102cellular response to zinc ion (GO:0071294)2.78247755
103negative regulation of cytokine production involved in immune response (GO:0002719)2.77955617
104T cell selection (GO:0045058)2.77722860
105natural killer cell mediated immunity (GO:0002228)2.77107813
106natural killer cell mediated cytotoxicity (GO:0042267)2.77107813
107positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.76857207
108regulation of chronic inflammatory response (GO:0002676)2.70951357
109antigen processing and presentation via MHC class Ib (GO:0002475)2.70112015
110negative regulation of viral entry into host cell (GO:0046597)2.69653316
111regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66782508
112dendritic cell differentiation (GO:0097028)2.65594641
113myeloid dendritic cell activation (GO:0001773)2.65120831
114regulation of natural killer cell differentiation (GO:0032823)2.64809272
115production of molecular mediator involved in inflammatory response (GO:0002532)2.64597779
116defense response to virus (GO:0051607)2.62829570
117NIK/NF-kappaB signaling (GO:0038061)2.60975328
118regulation of cholesterol esterification (GO:0010872)2.59869487
119pyridine nucleotide biosynthetic process (GO:0019363)2.59264141
120nicotinamide nucleotide biosynthetic process (GO:0019359)2.59264141
121phospholipid efflux (GO:0033700)2.58376742
122positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.56415222
123positive regulation of defense response to virus by host (GO:0002230)2.56180983
124myeloid dendritic cell differentiation (GO:0043011)2.55450562
125regulation of viral genome replication (GO:0045069)2.55135663
126neutrophil activation (GO:0042119)2.55036394
127regulation of type I interferon-mediated signaling pathway (GO:0060338)2.54877984
128regulation of defense response to virus by host (GO:0050691)2.54836441
129polyketide metabolic process (GO:0030638)2.54081121
130doxorubicin metabolic process (GO:0044598)2.54081121
131daunorubicin metabolic process (GO:0044597)2.54081121
132cellular response to thyroid hormone stimulus (GO:0097067)2.53221532
133regulation of hypersensitivity (GO:0002883)2.52032338
134negative regulation of viral process (GO:0048525)2.51961176
135positive regulation of B cell differentiation (GO:0045579)2.51897725
136granulocyte activation (GO:0036230)2.51530862
137hemoglobin metabolic process (GO:0020027)2.50777051
138hydrogen peroxide biosynthetic process (GO:0050665)2.50136333
139response to interferon-gamma (GO:0034341)2.48714581
140very-low-density lipoprotein particle assembly (GO:0034379)2.46635273
141positive regulation of interleukin-12 production (GO:0032735)2.46109696
142indole-containing compound catabolic process (GO:0042436)2.46079357
143indolalkylamine catabolic process (GO:0046218)2.46079357
144tryptophan catabolic process (GO:0006569)2.46079357
145positive regulation of chemokine biosynthetic process (GO:0045080)2.45853439
146lipopolysaccharide-mediated signaling pathway (GO:0031663)2.45253981
147positive regulation of T cell mediated cytotoxicity (GO:0001916)2.44573755
148ribosomal small subunit assembly (GO:0000028)2.43781366
149positive regulation of gamma-delta T cell activation (GO:0046645)2.42737638
150triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.42652814
151aldehyde catabolic process (GO:0046185)2.41475289
152tetrapyrrole metabolic process (GO:0033013)2.40001488
153plasma lipoprotein particle assembly (GO:0034377)2.39787363
154regulation of interleukin-12 biosynthetic process (GO:0045075)2.39583702
155cellular response to interferon-gamma (GO:0071346)2.38826133
156tryptophan metabolic process (GO:0006568)2.35976764
157positive regulation of T cell migration (GO:2000406)2.34270101
158regulation of alpha-beta T cell proliferation (GO:0046640)2.32492935
159response to thyroid hormone (GO:0097066)2.31334073
160regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.30758309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.82318726
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.55805380
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.22616099
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.10391713
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.54577565
6GATA1_22025678_ChIP-Seq_K562_Human3.54032940
7E2F7_22180533_ChIP-Seq_HELA_Human3.37423150
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33708496
9* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.19849780
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.81174596
11SCL_19346495_ChIP-Seq_HPC-7_Human2.73287699
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67225623
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.57638539
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40551395
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39052761
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36750497
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32609340
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29217912
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.26740682
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22270628
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21985547
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19516482
23RUNX_20019798_ChIP-Seq_JUKART_Human2.10567478
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07438342
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03768749
26* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00087742
27* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99765088
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94023308
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91350112
30SPI1_23547873_ChIP-Seq_NB4_Human1.82930937
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81547000
32GATA3_27048872_Chip-Seq_THYMUS_Human1.81283835
33* GATA1_19941827_ChIP-Seq_MEL_Mouse1.78495946
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75207957
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74676184
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69716964
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68370354
38GATA1_22383799_ChIP-Seq_G1ME_Mouse1.67599855
39* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65041401
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62263534
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62063357
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56291487
43GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53065585
44BCL6_27268052_Chip-Seq_Bcells_Human1.52044094
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.50851663
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50635744
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.48606414
48GATA1_19941826_ChIP-Seq_K562_Human1.47981167
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46789070
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45780544
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.45095085
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44621840
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44339658
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43066966
55* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40923856
56KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.40442763
57MYB_26560356_Chip-Seq_TH2_Human1.39046881
58* SRF_21415370_ChIP-Seq_HL-1_Mouse1.37531725
59CIITA_25753668_ChIP-Seq_RAJI_Human1.35195621
60MYB_26560356_Chip-Seq_TH1_Human1.34715525
61* MAF_26560356_Chip-Seq_TH1_Human1.34568078
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33641619
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33282807
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.30240105
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29050794
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24091218
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.21892292
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21670021
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20792276
70VDR_21846776_ChIP-Seq_THP-1_Human1.17021235
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14594722
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13128167
73VDR_24763502_ChIP-Seq_THP-1_Human1.11394811
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10930350
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10769626
76PU_27001747_Chip-Seq_BMDM_Mouse1.09829476
77BCOR_27268052_Chip-Seq_Bcells_Human1.09755149
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09194047
79VDR_24787735_ChIP-Seq_THP-1_Human1.07512231
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07077299
81MYC_22102868_ChIP-Seq_BL_Human1.07072475
82VDR_23849224_ChIP-Seq_CD4+_Human1.06298100
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04795965
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.03054130
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02068569
86P300_27268052_Chip-Seq_Bcells_Human1.01954392
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.01166433
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.01126218
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00643244
90STAT1_20625510_ChIP-Seq_HELA_Human1.00364827
91GATA2_19941826_ChIP-Seq_K562_Human1.00362453
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00289894
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99787978
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98606664
95TFEB_21752829_ChIP-Seq_HELA_Human0.97396626
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96940691
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96222056
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95839746
99FOXP3_21729870_ChIP-Seq_TREG_Human0.95529472
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94098025
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.92054000
102MAF_26560356_Chip-Seq_TH2_Human0.91860733
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91838515
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90949301
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90700502
106UTX_26944678_Chip-Seq_JUKART_Human0.90183349
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89501062
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88970327
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.88900028
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88765040
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88606166
112MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88241195
113* CTCF_26484167_Chip-Seq_Bcells_Mouse0.87967802
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87816604
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87785150
116E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87099604
117GATA3_26560356_Chip-Seq_TH2_Human0.86436629
118MYC_18555785_ChIP-Seq_MESCs_Mouse0.86225514
119ELK1_19687146_ChIP-ChIP_HELA_Human0.85803160
120SPI1_23127762_ChIP-Seq_K562_Human0.84691840
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83652979
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82969360
123FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82028820
124* SA1_27219007_Chip-Seq_Bcells_Human0.81326694
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81012631
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80908621
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80292982
128* SPI1_20517297_ChIP-Seq_HL60_Human0.79259484
129EGR1_19032775_ChIP-ChIP_M12_Human0.79082703
130RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79070871
131RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78478203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.14406931
2MP0003656_abnormal_erythrocyte_physiolo3.74306767
3MP0009785_altered_susceptibility_to3.32361753
4MP0000685_abnormal_immune_system3.17404122
5MP0004147_increased_porphyrin_level2.96433769
6MP0002148_abnormal_hypersensitivity_rea2.72603283
7MP0003436_decreased_susceptibility_to2.69374655
8MP0005025_abnormal_response_to2.51671425
9MP0005671_abnormal_response_to2.46817090
10MP0005387_immune_system_phenotype2.39724506
11MP0001790_abnormal_immune_system2.39724506
12MP0002139_abnormal_hepatobiliary_system2.36835302
13MP0003724_increased_susceptibility_to2.30288238
14MP0005000_abnormal_immune_tolerance2.19788184
15MP0006082_CNS_inflammation2.17906111
16MP0005360_urolithiasis2.11777886
17MP0005464_abnormal_platelet_physiology2.11063168
18MP0002419_abnormal_innate_immunity2.09847242
19MP0001800_abnormal_humoral_immune2.07878507
20MP0002138_abnormal_hepatobiliary_system2.07074945
21MP0001545_abnormal_hematopoietic_system2.06198468
22MP0005397_hematopoietic_system_phenotyp2.06198468
23MP0002452_abnormal_antigen_presenting1.97299516
24MP0002723_abnormal_immune_serum1.96040560
25MP0003191_abnormal_cellular_cholesterol1.94628791
26MP0003186_abnormal_redox_activity1.89983318
27MP0009840_abnormal_foam_cell1.86602783
28MP0005085_abnormal_gallbladder_physiolo1.84717301
29MP0001853_heart_inflammation1.82058540
30MP0009764_decreased_sensitivity_to1.81757949
31MP0003866_abnormal_defecation1.78798673
32MP0001819_abnormal_immune_cell1.76248797
33MP0002166_altered_tumor_susceptibility1.74936328
34MP0002420_abnormal_adaptive_immunity1.73969348
35MP0008469_abnormal_protein_level1.73207903
36MP0002398_abnormal_bone_marrow1.71321474
37MP0005365_abnormal_bile_salt1.64111475
38MP0000689_abnormal_spleen_morphology1.52297022
39MP0001845_abnormal_inflammatory_respons1.52240463
40MP0010155_abnormal_intestine_physiology1.51707409
41MP0000716_abnormal_immune_system1.50807959
42MP0008875_abnormal_xenobiotic_pharmacok1.49126923
43MP0002405_respiratory_system_inflammati1.46835126
44MP0004510_myositis1.46012050
45MP0002429_abnormal_blood_cell1.44086633
46MP0002006_tumorigenesis1.44053396
47MP0005083_abnormal_biliary_tract1.42380183
48MP0002396_abnormal_hematopoietic_system1.40908236
49MP0002722_abnormal_immune_system1.40431384
50MP0005310_abnormal_salivary_gland1.39642890
51MP0003806_abnormal_nucleotide_metabolis1.37031813
52MP0003011_delayed_dark_adaptation1.36206459
53MP0001348_abnormal_lacrimal_gland1.34952191
54MP0009697_abnormal_copulation1.29701926
55MP0004782_abnormal_surfactant_physiolog1.28135141
56MP0009333_abnormal_splenocyte_physiolog1.27774869
57MP0002653_abnormal_ependyma_morphology1.27451212
58MP0004947_skin_inflammation1.26337025
59MP0000490_abnormal_crypts_of1.25052183
60MP0002132_abnormal_respiratory_system1.24061889
61MP0009763_increased_sensitivity_to1.23459228
62MP0004808_abnormal_hematopoietic_stem1.22951597
63MP0002254_reproductive_system_inflammat1.19248613
64MP0005319_abnormal_enzyme/_coenzyme1.16922711
65MP0000609_abnormal_liver_physiology1.16650300
66MP0005058_abnormal_lysosome_morphology1.16388628
67MP0003252_abnormal_bile_duct1.14920476
68MP0010329_abnormal_lipoprotein_level1.13580282
69MP0000343_altered_response_to1.12194880
70MP0000604_amyloidosis1.11726977
71MP0003763_abnormal_thymus_physiology1.10640520
72MP0001533_abnormal_skeleton_physiology1.10523463
73MP0005166_decreased_susceptibility_to1.10422454
74MP0005075_abnormal_melanosome_morpholog1.10091160
75MP0009278_abnormal_bone_marrow1.09790401
76MP0001764_abnormal_homeostasis1.08538448
77MP0003195_calcinosis1.05700860
78MP0001873_stomach_inflammation1.04234674
79MP0005174_abnormal_tail_pigmentation1.03426222
80MP0002933_joint_inflammation0.98799711
81MP0002163_abnormal_gland_morphology0.97166241
82MP0009765_abnormal_xenobiotic_induced0.96526878
83MP0000598_abnormal_liver_morphology0.94465995
84MP0001663_abnormal_digestive_system0.93980769
85MP0003183_abnormal_peptide_metabolism0.92923256
86MP0010307_abnormal_tumor_latency0.91860876
87MP0005584_abnormal_enzyme/coenzyme_acti0.90776346
88MP0000858_altered_metastatic_potential0.90223840
89MP0002277_abnormal_respiratory_mucosa0.89357910
90MP0003448_altered_tumor_morphology0.88884493
91MP0008260_abnormal_autophagy0.87636627
92MP0004883_abnormal_blood_vessel0.86464900
93MP0008057_abnormal_DNA_replication0.85613828
94MP0005390_skeleton_phenotype0.83184942
95MP0005636_abnormal_mineral_homeostasis0.82686681
96MP0000465_gastrointestinal_hemorrhage0.79573736
97MP0003172_abnormal_lysosome_physiology0.79486676
98MP0003303_peritoneal_inflammation0.77447732
99MP0002998_abnormal_bone_remodeling0.76892423
100MP0002019_abnormal_tumor_incidence0.75306630
101MP0003075_altered_response_to0.74002912
102MP0004019_abnormal_vitamin_homeostasis0.73510272
103MP0002876_abnormal_thyroid_physiology0.73274920
104MP0005164_abnormal_response_to0.72886950
105MP0000703_abnormal_thymus_morphology0.70939586
106MP0001986_abnormal_taste_sensitivity0.70222547
107MP0002095_abnormal_skin_pigmentation0.69722064
108MP0009643_abnormal_urine_homeostasis0.69425346
109MP0001542_abnormal_bone_strength0.65248015
110MP0005332_abnormal_amino_acid0.64742585
111MP0006036_abnormal_mitochondrial_physio0.64237333
112MP0001905_abnormal_dopamine_level0.63373719
113MP0002877_abnormal_melanocyte_morpholog0.63159445
114MP0003690_abnormal_glial_cell0.62413951
115MP0003943_abnormal_hepatobiliary_system0.62364248
116MP0005451_abnormal_body_composition0.61132317
117MP0003300_gastrointestinal_ulcer0.60419468
118MP0003787_abnormal_imprinting0.59001860
119MP0008004_abnormal_stomach_pH0.56759188
120MP0008874_decreased_physiological_sensi0.56088488
121MP0001851_eye_inflammation0.55979906
122MP0005084_abnormal_gallbladder_morpholo0.54147690
123MP0008873_increased_physiological_sensi0.54005225
124MP0003795_abnormal_bone_structure0.53135307
125MP0000249_abnormal_blood_vessel0.51996535
126MP0003045_fibrosis0.51640640
127MP0005535_abnormal_body_temperature0.50687264
128MP0002693_abnormal_pancreas_physiology0.50586311
129MP0005381_digestive/alimentary_phenotyp0.49765029

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)6.14174419
2Poikilocytosis (HP:0004447)4.60270092
3Hypochromic microcytic anemia (HP:0004840)4.55306068
4Stomatitis (HP:0010280)4.52490442
5Autoimmune thrombocytopenia (HP:0001973)4.41390972
6Recurrent abscess formation (HP:0002722)4.08965782
7Recurrent bacterial skin infections (HP:0005406)3.87002178
8T lymphocytopenia (HP:0005403)3.83794938
9Abnormality of T cell number (HP:0011839)3.76920426
10Hypochromic anemia (HP:0001931)3.73629579
11Elevated erythrocyte sedimentation rate (HP:0003565)3.71929631
12Increased IgM level (HP:0003496)3.68713685
13Eczematoid dermatitis (HP:0000976)3.67207248
14Recurrent gram-negative bacterial infections (HP:0005420)3.65552623
15Panhypogammaglobulinemia (HP:0003139)3.56711980
16Obstructive lung disease (HP:0006536)3.55243108
17Chronic obstructive pulmonary disease (HP:0006510)3.55243108
18Petechiae (HP:0000967)3.40775113
19Microcytic anemia (HP:0001935)3.38442422
20Acanthocytosis (HP:0001927)3.34390582
21Agammaglobulinemia (HP:0004432)3.28938158
22Myositis (HP:0100614)3.25601256
23Gingival bleeding (HP:0000225)3.17576536
24Joint hemorrhage (HP:0005261)3.13050433
25Systemic lupus erythematosus (HP:0002725)3.08063884
26Chronic otitis media (HP:0000389)3.06726590
27Abnormality of B cell number (HP:0010975)3.04263692
28Severe combined immunodeficiency (HP:0004430)2.97647433
29Leukocytosis (HP:0001974)2.95505488
30Epistaxis (HP:0000421)2.94988519
31Hemoptysis (HP:0002105)2.94579899
32Abnormality of macrophages (HP:0004311)2.93656398
33Urticaria (HP:0001025)2.92501486
34Keratoconjunctivitis sicca (HP:0001097)2.91254564
35Hyperbilirubinemia (HP:0002904)2.89391703
36Purpura (HP:0000979)2.88241616
37Thrombocytosis (HP:0001894)2.87768313
38Orchitis (HP:0100796)2.86605373
39Prolonged partial thromboplastin time (HP:0003645)2.85775266
40Recurrent skin infections (HP:0001581)2.84166258
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.81679645
42Prolonged bleeding time (HP:0003010)2.80136659
43Granulocytopenia (HP:0001913)2.78570619
44Eosinophilia (HP:0001880)2.75816546
45Vasculitis (HP:0002633)2.75799399
46B lymphocytopenia (HP:0010976)2.75104187
47Abnormality of the nasal mucosa (HP:0000433)2.74986942
48Keratoconjunctivitis (HP:0001096)2.74563041
49Recurrent fungal infections (HP:0002841)2.72398006
50Reticulocytosis (HP:0001923)2.72353803
51Nasal polyposis (HP:0100582)2.71772869
52Nausea (HP:0002018)2.67902122
53Increased IgE level (HP:0003212)2.65132960
54Recurrent viral infections (HP:0004429)2.65088139
55Increased serum ferritin (HP:0003281)2.64893859
56Chest pain (HP:0100749)2.60580647
57Reduced antithrombin III activity (HP:0001976)2.58740161
58Abnormality of T cell physiology (HP:0011840)2.58350046
59Tetraparesis (HP:0002273)2.56916523
60Cholelithiasis (HP:0001081)2.54746102
61Polycythemia (HP:0001901)2.54588400
62Abnormality of aromatic amino acid family metabolism (HP:0004338)2.53403039
63Mediastinal lymphadenopathy (HP:0100721)2.53053337
64Abnormality of eosinophils (HP:0001879)2.52977625
65Abnormality of liposaccharide metabolism (HP:0010968)2.52103722
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.52103722
67Abnormality of glycolipid metabolism (HP:0010969)2.52103722
68Retrobulbar optic neuritis (HP:0100654)2.49339092
69Optic neuritis (HP:0100653)2.49339092
70Abnormality of pyrimidine metabolism (HP:0004353)2.48808954
71Gangrene (HP:0100758)2.48376523
72Lymphopenia (HP:0001888)2.48354636
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47561603
74Autoimmune hemolytic anemia (HP:0001890)2.46741628
75Pustule (HP:0200039)2.46412615
76Abnormality of the pleura (HP:0002103)2.45334884
77Abnormality of iron homeostasis (HP:0011031)2.45246022
78Combined immunodeficiency (HP:0005387)2.44188262
79Vacuolated lymphocytes (HP:0001922)2.42645411
80Abnormal gallbladder morphology (HP:0012437)2.38953362
81Spontaneous hematomas (HP:0007420)2.38053755
82Hypergammaglobulinemia (HP:0010702)2.37650172
83Chronic mucocutaneous candidiasis (HP:0002728)2.35987930
84Recurrent cutaneous fungal infections (HP:0011370)2.35987930
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.35959902
86Chronic diarrhea (HP:0002028)2.33508729
87Basal ganglia calcification (HP:0002135)2.33392674
88Anorexia (HP:0002039)2.33349876
89Gastrointestinal infarctions (HP:0005244)2.31454242
90Pulmonary embolism (HP:0002204)2.29950586
91Abnormality of reticulocytes (HP:0004312)2.27855840
92Inflammation of the large intestine (HP:0002037)2.26675390
93Cutaneous photosensitivity (HP:0000992)2.24250906
94Skin rash (HP:0000988)2.24172586
95Intrahepatic cholestasis (HP:0001406)2.19976632
96Thrombophlebitis (HP:0004418)2.19367735
97Spontaneous abortion (HP:0005268)2.19018383
98Recurrent sinusitis (HP:0011108)2.17302181
99Hypobetalipoproteinemia (HP:0003563)2.17122325
100Thyroiditis (HP:0100646)2.17060665
101Gastrointestinal inflammation (HP:0004386)2.17005296
102Acute hepatic failure (HP:0006554)2.16746754
103Abnormality of transition element cation homeostasis (HP:0011030)2.16262708
104Deep venous thrombosis (HP:0002625)2.15957317
105Abnormal number of erythroid precursors (HP:0012131)2.15547902
106Paralysis (HP:0003470)2.12959073
107Arterial thrombosis (HP:0004420)2.12125555
108Abnormal platelet function (HP:0011869)2.11458373
109Impaired platelet aggregation (HP:0003540)2.11458373
110Episodic fever (HP:0001954)2.10095683
111Joint swelling (HP:0001386)2.08479140
112Abnormality of the common coagulation pathway (HP:0010990)2.08440798
113Recurrent bronchitis (HP:0002837)2.08165734
114Hypoproteinemia (HP:0003075)2.07769544
115Gingivitis (HP:0000230)2.06564395
116Complement deficiency (HP:0004431)2.05823843
117Sepsis (HP:0100806)2.04928468
118Chronic sinusitis (HP:0011109)2.04725764
119Meningitis (HP:0001287)2.04519120
120Vertebral compression fractures (HP:0002953)2.04198537
121Periodontitis (HP:0000704)2.03690105
122IgM deficiency (HP:0002850)2.03594122
123Abnormality of T cells (HP:0002843)2.02222181
124Increased neuronal autofluorescent lipopigment (HP:0002074)2.01462471
125Osteomalacia (HP:0002749)2.00554418
126Myocardial infarction (HP:0001658)1.99633386
127Abnormality of the prostate (HP:0008775)1.98905754
128Abnormality of cells of the erythroid lineage (HP:0012130)1.98439405
129Xanthomatosis (HP:0000991)1.98285422
130Hepatocellular necrosis (HP:0001404)1.96076690
131Aplastic anemia (HP:0001915)1.95582854
132Hypertensive crisis (HP:0100735)1.94915960
133Encephalitis (HP:0002383)1.94744636
134Mitochondrial inheritance (HP:0001427)1.94187267
135Pulmonary infiltrates (HP:0002113)1.94054319
136Cellulitis (HP:0100658)1.93866488
137Poor head control (HP:0002421)1.93696503
138Hepatocellular carcinoma (HP:0001402)1.92996227
139Amaurosis fugax (HP:0100576)1.92160046
140Lower limb hyperreflexia (HP:0002395)1.92093114
141Stomach cancer (HP:0012126)1.91439728
142IgG deficiency (HP:0004315)1.89565148
143Premature loss of primary teeth (HP:0006323)1.88895066
144Interstitial pulmonary disease (HP:0006530)1.88747092
145Menorrhagia (HP:0000132)1.88701031
146Glomerulonephritis (HP:0000099)1.88176834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.62083156
2MAP3K143.36529866
3IRAK43.33685625
4TBK13.24429087
5TYK23.04706446
6IKBKE3.03735719
7KIT2.87946993
8NME22.61389219
9FES2.50931164
10IKBKB2.46095668
11EIF2AK12.44145720
12JAK32.33991327
13PIM22.23045774
14IRAK32.13886135
15TNK22.07275598
16MAP4K12.04943370
17FLT31.97597985
18FGFR41.80807857
19ERN11.68003422
20VRK21.66558722
21CHUK1.65455628
22PIM11.65406098
23BLK1.64509166
24PBK1.63905728
25STK41.62105556
26TXK1.61378590
27ITK1.60107455
28TGFBR21.57917866
29TLK11.53019216
30TAOK31.50412557
31SYK1.49244932
32CSF1R1.46981925
33ZAK1.39425653
34MATK1.38750067
35JAK11.38023290
36TIE11.35793042
37TESK11.35453511
38ZAP701.32247048
39TEC1.30388480
40ADRBK21.29725255
41NEK91.25713957
42MAP2K31.24193314
43STK161.15815341
44EIF2AK21.15211243
45BTK1.13689188
46BCKDK1.13514899
47MAP3K131.11187459
48MAP4K21.08882450
49VRK11.08447329
50LYN1.06748447
51PRKCQ1.05476167
52CDK191.04876097
53RPS6KA41.02287039
54FGR1.00263612
55MAPK110.98875759
56RPS6KA50.98821628
57RIPK40.92265692
58LIMK10.91356412
59PIK3CG0.90052575
60SIK30.89457016
61MST40.85659220
62DYRK30.82827602
63NUAK10.82768838
64EPHB10.82440842
65FGFR30.81454548
66CSK0.81335056
67CDK120.81104698
68LCK0.80968806
69JAK20.80336231
70MAP3K110.79662681
71PRPF4B0.79662058
72ABL20.79486139
73GRK60.74699947
74STK100.73595491
75ACVR1B0.73326922
76DAPK10.71282672
77EPHA30.71166400
78TRPM70.70062811
79BRSK20.69858798
80KDR0.67859518
81NLK0.66123058
82CDK60.66002698
83YES10.65980885
84HCK0.64854333
85TAOK10.64574451
86FYN0.62985660
87MARK30.62154807
88GRK50.61856341
89BMPR20.60667316
90WEE10.60407269
91DYRK1B0.59230108
92IRAK10.58595733
93GRK70.58018784
94PRKCD0.57806316
95MAP3K50.57441823
96RPS6KA60.54373278
97DYRK20.53852624
98HIPK20.52570938
99MAPKAPK20.51743012
100TGFBR10.49687036
101CDK40.48932560
102LRRK20.47164970
103BRD40.47144724
104MAP2K60.46884431
105MAP3K120.45509578
106TAOK20.43985456
107ATR0.42543914
108MYLK0.39439486
109SIK20.38843054
110GRK10.37588295
111MAP3K80.36318186
112PLK40.35653830
113MAPKAPK30.35250831
114CLK10.34725306
115MKNK10.33754450
116ABL10.33204406
117AURKB0.32899586
118PRKAA20.32647837
119BMPR1B0.32354021
120PINK10.31287913
121CSNK2A10.29824129
122PRKG20.29504601
123MAP3K30.29305177
124MAP3K10.28706313
125CDK70.27981849
126MOS0.27967113
127RPS6KC10.27774322
128DAPK20.27401205
129IRAK20.27141374
130IGF1R0.24629674
131PDK10.23882301
132CDC42BPA0.23642563
133MAPK40.22854785
134INSR0.22669793
135MAPK70.22501624
136DAPK30.21583119
137ADRBK10.21522806
138MAPK30.20835704

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.09333968
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.79716387
3Allograft rejection_Homo sapiens_hsa053302.75691066
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.33588332
5Staphylococcus aureus infection_Homo sapiens_hsa051502.31304252
6Leishmaniasis_Homo sapiens_hsa051402.22560433
7Caffeine metabolism_Homo sapiens_hsa002322.22250083
8Viral myocarditis_Homo sapiens_hsa054162.14662326
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.13754772
10Measles_Homo sapiens_hsa051622.05682767
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.02133552
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94882864
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.91036919
14Complement and coagulation cascades_Homo sapiens_hsa046101.83589804
15Herpes simplex infection_Homo sapiens_hsa051681.82190952
16Graft-versus-host disease_Homo sapiens_hsa053321.79310335
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74647993
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68123145
19DNA replication_Homo sapiens_hsa030301.62543786
20Malaria_Homo sapiens_hsa051441.61032657
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57332868
22Asthma_Homo sapiens_hsa053101.57150727
23Influenza A_Homo sapiens_hsa051641.49627606
24Legionellosis_Homo sapiens_hsa051341.47859139
25Proteasome_Homo sapiens_hsa030501.41422774
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38182552
27Systemic lupus erythematosus_Homo sapiens_hsa053221.37970556
28Antigen processing and presentation_Homo sapiens_hsa046121.37966940
29Ribosome_Homo sapiens_hsa030101.36469635
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33775092
31Primary immunodeficiency_Homo sapiens_hsa053401.32954396
32Hematopoietic cell lineage_Homo sapiens_hsa046401.31033381
33Autoimmune thyroid disease_Homo sapiens_hsa053201.29590012
34ABC transporters_Homo sapiens_hsa020101.29083600
35Pertussis_Homo sapiens_hsa051331.28260039
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27949295
37T cell receptor signaling pathway_Homo sapiens_hsa046601.27083812
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25122252
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.24134301
40Phagosome_Homo sapiens_hsa041451.22369306
41Tryptophan metabolism_Homo sapiens_hsa003801.21739989
42Folate biosynthesis_Homo sapiens_hsa007901.20368440
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14805359
44African trypanosomiasis_Homo sapiens_hsa051431.14326808
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.10824364
46Oxidative phosphorylation_Homo sapiens_hsa001901.09381127
47Apoptosis_Homo sapiens_hsa042101.06828618
48Base excision repair_Homo sapiens_hsa034101.04424876
49Salmonella infection_Homo sapiens_hsa051321.04312854
50Osteoclast differentiation_Homo sapiens_hsa043801.04129995
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01288946
52Mismatch repair_Homo sapiens_hsa034301.00898251
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99414752
54One carbon pool by folate_Homo sapiens_hsa006700.99238598
55Toxoplasmosis_Homo sapiens_hsa051450.98990121
56TNF signaling pathway_Homo sapiens_hsa046680.98485506
57Arginine biosynthesis_Homo sapiens_hsa002200.98046419
58Peroxisome_Homo sapiens_hsa041460.97797281
59Sulfur relay system_Homo sapiens_hsa041220.93043173
60Chemical carcinogenesis_Homo sapiens_hsa052040.91510598
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90333905
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89582173
63Tuberculosis_Homo sapiens_hsa051520.87355687
64Other glycan degradation_Homo sapiens_hsa005110.86092316
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85710626
66Parkinsons disease_Homo sapiens_hsa050120.85586038
67Histidine metabolism_Homo sapiens_hsa003400.83949048
68B cell receptor signaling pathway_Homo sapiens_hsa046620.82951345
69Pyrimidine metabolism_Homo sapiens_hsa002400.82345692
70Homologous recombination_Homo sapiens_hsa034400.82122442
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80749858
72Hepatitis C_Homo sapiens_hsa051600.80669693
73Vitamin B6 metabolism_Homo sapiens_hsa007500.78827332
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78671354
75p53 signaling pathway_Homo sapiens_hsa041150.77477046
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74510993
77Type I diabetes mellitus_Homo sapiens_hsa049400.74448407
78Selenocompound metabolism_Homo sapiens_hsa004500.74195935
79Pentose phosphate pathway_Homo sapiens_hsa000300.73762595
80Hepatitis B_Homo sapiens_hsa051610.73056903
81Fatty acid degradation_Homo sapiens_hsa000710.72359437
82Retinol metabolism_Homo sapiens_hsa008300.72232343
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.71870058
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70455756
85Rheumatoid arthritis_Homo sapiens_hsa053230.69036130
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68110596
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.61734988
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58992256
89Vitamin digestion and absorption_Homo sapiens_hsa049770.58197279
90Shigellosis_Homo sapiens_hsa051310.57404412
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57360163
92Collecting duct acid secretion_Homo sapiens_hsa049660.56729765
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56482750
94Chemokine signaling pathway_Homo sapiens_hsa040620.53643318
95Arachidonic acid metabolism_Homo sapiens_hsa005900.53548797
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52991146
97Acute myeloid leukemia_Homo sapiens_hsa052210.52853264
98Phenylalanine metabolism_Homo sapiens_hsa003600.52615950
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52302704
100Epstein-Barr virus infection_Homo sapiens_hsa051690.51511738
101Lysosome_Homo sapiens_hsa041420.51349400
102PPAR signaling pathway_Homo sapiens_hsa033200.50797770
103Viral carcinogenesis_Homo sapiens_hsa052030.50437392
104beta-Alanine metabolism_Homo sapiens_hsa004100.50095117
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49942650
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49902489
107Glutathione metabolism_Homo sapiens_hsa004800.49477875
108Galactose metabolism_Homo sapiens_hsa000520.48069501
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46733034
110Starch and sucrose metabolism_Homo sapiens_hsa005000.45783513
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45589991
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43822132
113Linoleic acid metabolism_Homo sapiens_hsa005910.42955848
114RNA polymerase_Homo sapiens_hsa030200.42839554
115Nucleotide excision repair_Homo sapiens_hsa034200.41835527
116Fanconi anemia pathway_Homo sapiens_hsa034600.41557615
117Alzheimers disease_Homo sapiens_hsa050100.41423635
118Regulation of autophagy_Homo sapiens_hsa041400.41376280
119Tyrosine metabolism_Homo sapiens_hsa003500.39800714
120Platelet activation_Homo sapiens_hsa046110.39031759
121HTLV-I infection_Homo sapiens_hsa051660.36328399
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35367052
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32237238
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.29463650
125Endocytosis_Homo sapiens_hsa041440.27770190
126Sulfur metabolism_Homo sapiens_hsa009200.26823547
127Huntingtons disease_Homo sapiens_hsa050160.22621728
128Prolactin signaling pathway_Homo sapiens_hsa049170.11607910
129Ether lipid metabolism_Homo sapiens_hsa005650.05808404
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05138508
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03891173
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03825398
133Fatty acid elongation_Homo sapiens_hsa000620.03005787
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.00527400

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