UBE2MP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)7.46783070
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.97063208
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.37323527
4ATP synthesis coupled proton transport (GO:0015986)6.37323527
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.38042229
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.25350276
7presynaptic membrane assembly (GO:0097105)5.20702389
8respiratory electron transport chain (GO:0022904)4.87389094
9electron transport chain (GO:0022900)4.81834551
10inner mitochondrial membrane organization (GO:0007007)4.75255567
11neuron cell-cell adhesion (GO:0007158)4.70391831
12chaperone-mediated protein transport (GO:0072321)4.57942922
13positive regulation of synaptic transmission, GABAergic (GO:0032230)4.56787568
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27786532
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.27786532
16NADH dehydrogenase complex assembly (GO:0010257)4.27786532
17presynaptic membrane organization (GO:0097090)4.19112263
18viral mRNA export from host cell nucleus (GO:0046784)4.17797438
19postsynaptic membrane organization (GO:0001941)4.16889950
20protein complex biogenesis (GO:0070271)4.05275684
21positive regulation of prostaglandin secretion (GO:0032308)4.05270863
22replicative senescence (GO:0090399)3.86438048
23negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.78928174
24DNA strand elongation involved in DNA replication (GO:0006271)3.76876068
25protein neddylation (GO:0045116)3.71636957
26coenzyme A biosynthetic process (GO:0015937)3.71530687
27ATP biosynthetic process (GO:0006754)3.69932557
28mitochondrial respiratory chain complex assembly (GO:0033108)3.67752031
29pyrimidine nucleobase catabolic process (GO:0006208)3.62914575
30DNA strand elongation (GO:0022616)3.61380800
31positive regulation of amino acid transport (GO:0051957)3.50248675
32innate immune response in mucosa (GO:0002227)3.48756815
33regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43917240
34intracellular protein transmembrane import (GO:0044743)3.42203485
35spliceosomal complex assembly (GO:0000245)3.41767799
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.39833204
37regulation of prostaglandin secretion (GO:0032306)3.38220431
38hydrogen ion transmembrane transport (GO:1902600)3.36955352
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.32803299
40viral transcription (GO:0019083)3.30360066
41translational termination (GO:0006415)3.29562714
42CENP-A containing nucleosome assembly (GO:0034080)3.28425638
43otic vesicle formation (GO:0030916)3.25082800
44chromatin remodeling at centromere (GO:0031055)3.24425587
45metanephric mesenchyme development (GO:0072075)3.24342447
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.24170579
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19572091
48vocalization behavior (GO:0071625)3.17963427
49telomere maintenance via semi-conservative replication (GO:0032201)3.16718494
50regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.16463683
51telomere maintenance via telomere lengthening (GO:0010833)3.15328083
52regulation of somitogenesis (GO:0014807)3.14090720
53ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10295737
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.08011587
55positive regulation of response to oxidative stress (GO:1902884)3.05580883
56positive regulation of cellular response to oxidative stress (GO:1900409)3.05580883
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05148434
58pseudouridine synthesis (GO:0001522)3.04738665
59negative regulation of membrane potential (GO:0045837)2.98302925
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96943141
61nucleosome assembly (GO:0006334)2.96120047
62establishment of protein localization to mitochondrion (GO:0072655)2.95863310
63hematopoietic stem cell proliferation (GO:0071425)2.95001814
64proton transport (GO:0015992)2.93902498
65translational elongation (GO:0006414)2.92883489
66protein localization to synapse (GO:0035418)2.92485636
67replication fork processing (GO:0031297)2.92138194
68kidney mesenchyme development (GO:0072074)2.91706144
69DNA replication checkpoint (GO:0000076)2.90560094
70protein-DNA complex assembly (GO:0065004)2.90337517
71positive regulation of synapse assembly (GO:0051965)2.89968402
72protein targeting to mitochondrion (GO:0006626)2.89785651
73regulation of cAMP-dependent protein kinase activity (GO:2000479)2.88241136
74regulation of mitochondrial translation (GO:0070129)2.86628113
75hydrogen transport (GO:0006818)2.83260243
76regulation of cell cycle G2/M phase transition (GO:1902749)2.82480131
77protein localization to mitochondrion (GO:0070585)2.82126219
78dendritic spine morphogenesis (GO:0060997)2.79580960
79protein transmembrane transport (GO:0071806)2.79389420
80nucleoside triphosphate biosynthetic process (GO:0009142)2.79275698
81maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77067603
82intracellular protein transmembrane transport (GO:0065002)2.76971040
83positive regulation of organic acid transport (GO:0032892)2.76288032
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.75172516
85cotranslational protein targeting to membrane (GO:0006613)2.74106000
86ribosomal large subunit biogenesis (GO:0042273)2.72750322
87protein targeting to ER (GO:0045047)2.72660384
88establishment of mitochondrion localization (GO:0051654)2.72439981
89pantothenate metabolic process (GO:0015939)2.71282076
90regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.68567337
91spinal cord association neuron differentiation (GO:0021527)2.66504114
92DNA replication-dependent nucleosome assembly (GO:0006335)2.66406171
93DNA replication-dependent nucleosome organization (GO:0034723)2.66406171
94transcription elongation from RNA polymerase III promoter (GO:0006385)2.65116917
95termination of RNA polymerase III transcription (GO:0006386)2.65116917
96regulation of synapse structural plasticity (GO:0051823)2.64575332
97establishment of protein localization to endoplasmic reticulum (GO:0072599)2.64528054
98positive regulation of RNA splicing (GO:0033120)2.63873726
99mucosal immune response (GO:0002385)2.63208550
100antibacterial humoral response (GO:0019731)2.63020720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.89266775
2E2F7_22180533_ChIP-Seq_HELA_Human5.22772021
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.06852940
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.51868907
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.29982874
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.75975194
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.63322125
8SOX2_16153702_ChIP-ChIP_HESCs_Human2.59074822
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58938947
10MYC_18940864_ChIP-ChIP_HL60_Human2.41848161
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.41423979
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40144671
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.33431742
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.26536853
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25843157
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17946672
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14622272
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.09907156
19RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.05405949
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05255155
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.04876964
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96875224
23XRN2_22483619_ChIP-Seq_HELA_Human1.90856200
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90603506
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88126693
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86314721
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.84437747
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.84111027
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80655289
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.80327710
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79925324
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79139747
33VDR_23849224_ChIP-Seq_CD4+_Human1.78992406
34ZNF274_21170338_ChIP-Seq_K562_Hela1.78716785
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74316875
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65867803
37SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.64985001
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64260176
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.61918210
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60530055
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56082941
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51348274
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50760917
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48780745
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.43987502
46KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42959184
47IRF1_19129219_ChIP-ChIP_H3396_Human1.41420642
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.37354376
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37228554
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34882752
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33036322
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31362445
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30907375
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29789677
55TTF2_22483619_ChIP-Seq_HELA_Human1.29522986
56GATA1_22025678_ChIP-Seq_K562_Human1.27828653
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.27509434
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27215541
59FOXP3_21729870_ChIP-Seq_TREG_Human1.23644910
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22785449
61VDR_22108803_ChIP-Seq_LS180_Human1.21019700
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16302263
63RNF2_27304074_Chip-Seq_NSC_Mouse1.13492257
64EZH2_22144423_ChIP-Seq_EOC_Human1.09553947
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08090466
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06594752
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06560592
68LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05947890
69DCP1A_22483619_ChIP-Seq_HELA_Human1.05632985
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05418491
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04774020
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04495309
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03952722
74FUS_26573619_Chip-Seq_HEK293_Human1.02703502
75GABP_19822575_ChIP-Seq_HepG2_Human1.02304630
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00830131
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00830131
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98953449
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96514885
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95963341
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95111312
82CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94515288
83ERG_20517297_ChIP-Seq_VCAP_Human0.92335267
84REST_21632747_ChIP-Seq_MESCs_Mouse0.91824154
85JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91795248
86AR_21572438_ChIP-Seq_LNCaP_Human0.91769050
87ELK1_19687146_ChIP-ChIP_HELA_Human0.91189010
88EZH2_27304074_Chip-Seq_ESCs_Mouse0.90083431
89SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89728388
90YY1_22570637_ChIP-Seq_MALME-3M_Human0.86334463
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.85448517
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84396392
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.84336672
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.83486535
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.81527963
96AR_21909140_ChIP-Seq_LNCAP_Human0.81260012
97NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80369340
98JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80002330
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79759663
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79220275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.73288900
2MP0003646_muscle_fatigue4.00507413
3MP0005645_abnormal_hypothalamus_physiol3.45786282
4MP0010030_abnormal_orbit_morphology3.15286237
5MP0006276_abnormal_autonomic_nervous3.09754309
6MP0009379_abnormal_foot_pigmentation3.05853798
7MP0003693_abnormal_embryo_hatching3.01846060
8MP0001529_abnormal_vocalization2.93026501
9MP0003121_genomic_imprinting2.79719185
10MP0002735_abnormal_chemical_nociception2.67604972
11MP0009046_muscle_twitch2.58610704
12MP0004133_heterotaxia2.20305064
13MP0000566_synostosis2.20138245
14MP0005423_abnormal_somatic_nervous2.18877107
15MP0003880_abnormal_central_pattern2.18698538
16MP0000751_myopathy2.17624066
17MP0004145_abnormal_muscle_electrophysio2.12702505
18MP0004270_analgesia2.11668093
19MP0002837_dystrophic_cardiac_calcinosis2.07262140
20MP0000750_abnormal_muscle_regeneration1.97465076
21MP0005084_abnormal_gallbladder_morpholo1.93056015
22MP0000631_abnormal_neuroendocrine_gland1.78742384
23MP0001727_abnormal_embryo_implantation1.76279979
24MP0003011_delayed_dark_adaptation1.72411082
25MP0001984_abnormal_olfaction1.68245209
26MP0005670_abnormal_white_adipose1.64067433
27MP0000749_muscle_degeneration1.63120998
28MP0000778_abnormal_nervous_system1.61764083
29MP0004859_abnormal_synaptic_plasticity1.52377193
30MP0000747_muscle_weakness1.50782396
31MP0001346_abnormal_lacrimal_gland1.49005238
32MP0002638_abnormal_pupillary_reflex1.48253748
33MP0010094_abnormal_chromosome_stability1.46085636
34MP0002332_abnormal_exercise_endurance1.43444144
35MP0002138_abnormal_hepatobiliary_system1.37515403
36MP0008872_abnormal_physiological_respon1.37246635
37MP0001299_abnormal_eye_distance/1.34082775
38MP0002697_abnormal_eye_size1.26599043
39MP0000372_irregular_coat_pigmentation1.25081133
40MP0002557_abnormal_social/conspecific_i1.21174992
41MP0004142_abnormal_muscle_tone1.18594685
42MP0004130_abnormal_muscle_cell1.16370779
43MP0002734_abnormal_mechanical_nocicepti1.15871850
44MP0003937_abnormal_limbs/digits/tail_de1.14963401
45MP0005386_behavior/neurological_phenoty1.13921849
46MP0004924_abnormal_behavior1.13921849
47MP0008058_abnormal_DNA_repair1.13800442
48MP0003635_abnormal_synaptic_transmissio1.13279950
49MP0009745_abnormal_behavioral_response1.12882907
50MP0002733_abnormal_thermal_nociception1.09242061
51MP0002928_abnormal_bile_duct1.04945270
52MP0002282_abnormal_trachea_morphology1.03979776
53MP0003136_yellow_coat_color1.03763139
54MP0002938_white_spotting1.03111605
55MP0008770_decreased_survivor_rate1.02992368
56MP0002106_abnormal_muscle_physiology1.02714737
57MP0002064_seizures1.02712958
58MP0001440_abnormal_grooming_behavior1.01110407
59MP0000026_abnormal_inner_ear1.00960209
60MP0002736_abnormal_nociception_after1.00730609
61MP0003938_abnormal_ear_development0.99643105
62MP0001968_abnormal_touch/_nociception0.97690998
63MP0004185_abnormal_adipocyte_glucose0.97185410
64MP0001970_abnormal_pain_threshold0.96999190
65MP0002272_abnormal_nervous_system0.96687642
66MP0000579_abnormal_nail_morphology0.96678245
67MP0002572_abnormal_emotion/affect_behav0.95830539
68MP0002089_abnormal_postnatal_growth/wei0.94063050
69MP0001188_hyperpigmentation0.93969764
70MP0005623_abnormal_meninges_morphology0.93791382
71MP0001270_distended_abdomen0.90225849
72MP0004957_abnormal_blastocyst_morpholog0.88294730
73MP0001905_abnormal_dopamine_level0.87826910
74MP0009250_abnormal_appendicular_skeleto0.85138021
75MP0000537_abnormal_urethra_morphology0.83640712
76MP0002752_abnormal_somatic_nervous0.82880964
77MP0002822_catalepsy0.81766698
78MP0004811_abnormal_neuron_physiology0.81316152
79MP0002139_abnormal_hepatobiliary_system0.80735551
80MP0006072_abnormal_retinal_apoptosis0.79699372
81MP0003077_abnormal_cell_cycle0.77728074
82MP0005369_muscle_phenotype0.77512498
83MP0005266_abnormal_metabolism0.76278073
84MP0003111_abnormal_nucleus_morphology0.75042877
85MP0002876_abnormal_thyroid_physiology0.74606365
86MP0004885_abnormal_endolymph0.72713164
87MP0005332_abnormal_amino_acid0.70898837
88MP0002277_abnormal_respiratory_mucosa0.69215211
89MP0004742_abnormal_vestibular_system0.69147125
90MP0003221_abnormal_cardiomyocyte_apopto0.69008820
91MP0002882_abnormal_neuron_morphology0.68383010
92MP0002067_abnormal_sensory_capabilities0.68092479
93MP0008995_early_reproductive_senescence0.66961980
94MP0002152_abnormal_brain_morphology0.66365211
95MP0002269_muscular_atrophy0.66332971
96MP0001873_stomach_inflammation0.66047086
97MP0005666_abnormal_adipose_tissue0.65706433
98MP0002063_abnormal_learning/memory/cond0.65416165
99MP0001286_abnormal_eye_development0.65177466
100MP0002081_perinatal_lethality0.64096430

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)7.12712134
2Reticulocytopenia (HP:0001896)4.65787709
3Increased hepatocellular lipid droplets (HP:0006565)4.61912118
4Lipid accumulation in hepatocytes (HP:0006561)4.52312915
5Calf muscle hypertrophy (HP:0008981)4.07710175
63-Methylglutaconic aciduria (HP:0003535)3.97669931
7Muscle hypertrophy of the lower extremities (HP:0008968)3.78329288
8Mitochondrial inheritance (HP:0001427)3.78290126
9Renal Fanconi syndrome (HP:0001994)3.68593305
10Nemaline bodies (HP:0003798)3.63119068
11Acute necrotizing encephalopathy (HP:0006965)3.58270794
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.39391387
13Muscle fiber inclusion bodies (HP:0100299)3.35154491
14Abnormal mitochondria in muscle tissue (HP:0008316)3.25470184
15Increased intramyocellular lipid droplets (HP:0012240)3.22655889
16Increased CSF lactate (HP:0002490)3.18473839
17Duplicated collecting system (HP:0000081)3.09921084
18Progressive macrocephaly (HP:0004481)2.99419724
19Acute encephalopathy (HP:0006846)2.98190519
20Increased muscle lipid content (HP:0009058)2.95023973
21Morphological abnormality of the pyramidal tract (HP:0002062)2.87807294
22Limb-girdle muscle atrophy (HP:0003797)2.82810338
23Myoglobinuria (HP:0002913)2.72946557
24Abnormality of the renal collecting system (HP:0004742)2.71176445
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69221802
26Sleep apnea (HP:0010535)2.64373826
27Distal lower limb amyotrophy (HP:0008944)2.61022434
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59715406
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.59715406
30Duplication of thumb phalanx (HP:0009942)2.58922814
31Limb dystonia (HP:0002451)2.58306387
32Abnormal finger flexion creases (HP:0006143)2.52600845
33Type II lissencephaly (HP:0007260)2.50894404
34Absent thumb (HP:0009777)2.44378879
35Hyperglycinemia (HP:0002154)2.44205791
36Myotonia (HP:0002486)2.43937858
37Exertional dyspnea (HP:0002875)2.41132074
38Rough bone trabeculation (HP:0100670)2.40291540
39Shoulder girdle muscle weakness (HP:0003547)2.35266844
40Abnormal trabecular bone morphology (HP:0100671)2.34803062
41Lower limb amyotrophy (HP:0007210)2.33778271
42Abnormality of the corticospinal tract (HP:0002492)2.33671785
43Difficulty climbing stairs (HP:0003551)2.31741167
44Absent phalangeal crease (HP:0006109)2.30879781
45Leukodystrophy (HP:0002415)2.28817589
46Macrocytic anemia (HP:0001972)2.27480513
47Abnormal number of erythroid precursors (HP:0012131)2.27218080
48Abnormality of renal resorption (HP:0011038)2.25120400
49Cerebral edema (HP:0002181)2.21500236
50Cerebellar dysplasia (HP:0007033)2.20985255
51Pelvic girdle muscle weakness (HP:0003749)2.19439572
52Rimmed vacuoles (HP:0003805)2.17667133
53Exercise intolerance (HP:0003546)2.17003908
54Exercise-induced muscle cramps (HP:0003710)2.14829423
55Short femoral neck (HP:0100864)2.14365489
56Hemiplegia (HP:0002301)2.10403502
57Hepatocellular necrosis (HP:0001404)2.09638454
58Pachygyria (HP:0001302)2.08889988
59Rhabdomyolysis (HP:0003201)2.07993110
60Respiratory difficulties (HP:0002880)2.07582501
61Ureteral duplication (HP:0000073)2.03570218
62Lactic acidosis (HP:0003128)2.01457781
63Partial duplication of thumb phalanx (HP:0009944)1.97351311
64Abnormality of cells of the erythroid lineage (HP:0012130)1.96924178
65Abnormality of the calf musculature (HP:0001430)1.94156698
66Horseshoe kidney (HP:0000085)1.93170879
67Neoplasm of the heart (HP:0100544)1.92963917
68Anomalous pulmonary venous return (HP:0010772)1.88107558
69Lissencephaly (HP:0001339)1.87285998
70Congenital, generalized hypertrichosis (HP:0004540)1.86455159
71IgM deficiency (HP:0002850)1.86394536
72Hepatic necrosis (HP:0002605)1.85587409
73Polyphagia (HP:0002591)1.85219109
74Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84745294
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84745294
76Myokymia (HP:0002411)1.84355150
77Optic disc pallor (HP:0000543)1.84343612
78Meningioma (HP:0002858)1.84289785
79Hypoventilation (HP:0002791)1.82903159
80Down-sloping shoulders (HP:0200021)1.81779337
81Aplasia/hypoplasia of the uterus (HP:0008684)1.81719094
82Meningocele (HP:0002435)1.80710352
83Abnormality of the labia minora (HP:0012880)1.79462747
84Partial duplication of the phalanx of hand (HP:0009999)1.79104592
85Large eyes (HP:0001090)1.78756612
86Hemivertebrae (HP:0002937)1.76472103
87Microvesicular hepatic steatosis (HP:0001414)1.74140210
88Homocystinuria (HP:0002156)1.73110307
89Abnormality of homocysteine metabolism (HP:0010919)1.73110307
90Fibular aplasia (HP:0002990)1.71877565
91Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71056553
92Abnormality of reticulocytes (HP:0004312)1.70919697
93Abnormality of the musculature of the pelvis (HP:0001469)1.70097552
94Abnormality of the hip-girdle musculature (HP:0001445)1.70097552
95Unilateral renal agenesis (HP:0000122)1.69794232
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69312181
97Esotropia (HP:0000565)1.68709028
98EMG: myopathic abnormalities (HP:0003458)1.68578491
99Frequent falls (HP:0002359)1.68441780
100Megaloblastic anemia (HP:0001889)1.67870951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.83867518
2ZAK4.91904913
3VRK13.71084560
4BLK3.70852045
5MAP3K93.66917246
6MARK13.43228612
7EPHA33.36246879
8MAP2K73.26842842
9CDC72.83501928
10DYRK22.80721512
11PHKG22.43954620
12PHKG12.43954620
13MAP3K42.32819744
14EPHB22.27094178
15OBSCN1.95103186
16MAP2K41.84206224
17ERBB31.76729855
18DAPK31.76660458
19RPS6KA51.75600441
20VRK21.59215989
21AURKA1.43747302
22TRIM281.35897747
23CDK81.30137174
24CHEK21.24475859
25BCKDK1.17533316
26MAPK131.01120046
27BUB11.00955466
28MAP3K60.99760634
29NTRK20.99251595
30TRIB30.90203162
31PKN10.86603917
32NTRK10.86135311
33UHMK10.85636980
34PINK10.83994702
35MAPK120.79922125
36TTN0.79194067
37AKT20.76532751
38ATR0.74503607
39NEK10.69494476
40RET0.67889974
41CCNB10.65815158
42FGFR20.65382290
43PIM10.61260189
44BMPR1B0.58610689
45GRK10.57108828
46CDK90.56898456
47MAPKAPK50.55405285
48WNK30.55373469
49SGK2230.55204713
50SGK4940.55204713
51STK240.50800678
52CASK0.50179272
53AURKB0.46697087
54CSNK1G20.46221428
55DYRK30.44585153
56CSNK2A20.44530387
57LATS20.44035865
58SRPK10.43761430
59PRKD30.43138666
60ILK0.41977191
61ALK0.41501406
62PRKDC0.41263137
63MAPK150.41139773
64PLK30.39470462
65TNIK0.38340941
66NME10.36001139
67PBK0.35701566
68MAPK40.34197813
69PIM20.33591564
70MKNK20.32552640
71CAMK40.32336189
72CSNK2A10.31816890
73TGFBR10.30020947
74STK160.28814940
75KSR10.27997101
76ADRBK20.27276708
77PRKCZ0.26652442
78MAP3K140.25838620
79PRKACA0.25343295
80PAK30.24971346
81SYK0.24525435
82PRKCG0.24339176
83PASK0.23548833
84MUSK0.23354115
85PRKCQ0.23177525
86ATM0.22083814
87PRKG10.21553135
88CDK20.21141255
89DYRK1B0.20905197
90DAPK20.20793974
91SGK10.20613402
92INSRR0.19916576
93NTRK30.18449303
94MAP3K100.17148196
95STK40.16735976
96LMTK20.16233943
97ERN10.15988763
98CAMK2A0.15931157
99EGFR0.15539883
100PLK10.13692562

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053226.00162805
2Oxidative phosphorylation_Homo sapiens_hsa001904.71668219
3Alcoholism_Homo sapiens_hsa050344.63991677
4Parkinsons disease_Homo sapiens_hsa050124.13887620
5Alzheimers disease_Homo sapiens_hsa050103.22264860
6Huntingtons disease_Homo sapiens_hsa050163.01157305
7Ribosome_Homo sapiens_hsa030102.82834707
8DNA replication_Homo sapiens_hsa030302.82036492
9Cardiac muscle contraction_Homo sapiens_hsa042602.72475271
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.59872896
11Mismatch repair_Homo sapiens_hsa034302.51385028
12Protein export_Homo sapiens_hsa030602.45389303
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14033132
14RNA polymerase_Homo sapiens_hsa030201.73123360
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71406514
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.64140048
17Proteasome_Homo sapiens_hsa030501.54816271
18Nucleotide excision repair_Homo sapiens_hsa034201.53843493
19Basal cell carcinoma_Homo sapiens_hsa052171.48790775
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40357441
21Homologous recombination_Homo sapiens_hsa034401.32756379
22Spliceosome_Homo sapiens_hsa030401.30193230
23Nicotine addiction_Homo sapiens_hsa050331.27056495
24Fanconi anemia pathway_Homo sapiens_hsa034601.26461375
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18398809
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.17231962
27Viral carcinogenesis_Homo sapiens_hsa052031.12021891
28Pyruvate metabolism_Homo sapiens_hsa006200.97038351
29Butanoate metabolism_Homo sapiens_hsa006500.96790551
30Selenocompound metabolism_Homo sapiens_hsa004500.93218278
31Sulfur relay system_Homo sapiens_hsa041220.88120456
32Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80210488
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79978947
34Glutamatergic synapse_Homo sapiens_hsa047240.79312796
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73173781
36Propanoate metabolism_Homo sapiens_hsa006400.72349686
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71901387
38RNA degradation_Homo sapiens_hsa030180.70917587
39Biosynthesis of amino acids_Homo sapiens_hsa012300.69964481
40Pyrimidine metabolism_Homo sapiens_hsa002400.68910502
41Phenylalanine metabolism_Homo sapiens_hsa003600.66409993
42Carbon metabolism_Homo sapiens_hsa012000.64796927
43Asthma_Homo sapiens_hsa053100.62513865
44Hedgehog signaling pathway_Homo sapiens_hsa043400.61728646
45Tryptophan metabolism_Homo sapiens_hsa003800.61110550
46Olfactory transduction_Homo sapiens_hsa047400.60191688
47Base excision repair_Homo sapiens_hsa034100.59946276
48Cocaine addiction_Homo sapiens_hsa050300.58565083
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57948800
50GABAergic synapse_Homo sapiens_hsa047270.55194169
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55185341
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54920308
53Melanogenesis_Homo sapiens_hsa049160.50296323
54Fructose and mannose metabolism_Homo sapiens_hsa000510.48426618
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48204739
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45560692
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45397545
58Cell cycle_Homo sapiens_hsa041100.45375536
59Prolactin signaling pathway_Homo sapiens_hsa049170.45304198
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43909629
61Cholinergic synapse_Homo sapiens_hsa047250.43869515
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43548503
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43291624
64Purine metabolism_Homo sapiens_hsa002300.43031762
65One carbon pool by folate_Homo sapiens_hsa006700.41872098
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41597531
67Morphine addiction_Homo sapiens_hsa050320.40892126
68Phototransduction_Homo sapiens_hsa047440.40371040
69Circadian entrainment_Homo sapiens_hsa047130.39283546
70Dopaminergic synapse_Homo sapiens_hsa047280.38817177
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37533669
72Basal transcription factors_Homo sapiens_hsa030220.36817435
73Epstein-Barr virus infection_Homo sapiens_hsa051690.36524713
74Steroid biosynthesis_Homo sapiens_hsa001000.35042818
75RNA transport_Homo sapiens_hsa030130.33615745
76Collecting duct acid secretion_Homo sapiens_hsa049660.33427668
77Serotonergic synapse_Homo sapiens_hsa047260.33225850
78Hippo signaling pathway_Homo sapiens_hsa043900.33196794
79Autoimmune thyroid disease_Homo sapiens_hsa053200.32996956
80Wnt signaling pathway_Homo sapiens_hsa043100.31051050
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30457628
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29995255
83Synaptic vesicle cycle_Homo sapiens_hsa047210.29273162
84Allograft rejection_Homo sapiens_hsa053300.28301925
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.27797236
86Metabolic pathways_Homo sapiens_hsa011000.27787360
87mRNA surveillance pathway_Homo sapiens_hsa030150.27427064
88Arginine and proline metabolism_Homo sapiens_hsa003300.25905036
89p53 signaling pathway_Homo sapiens_hsa041150.23918307
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23083376
91Pentose phosphate pathway_Homo sapiens_hsa000300.22978937
92Dilated cardiomyopathy_Homo sapiens_hsa054140.22161777
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19775844
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19009516
95Glutathione metabolism_Homo sapiens_hsa004800.18486547
96Oocyte meiosis_Homo sapiens_hsa041140.17475311
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14970147
98Amphetamine addiction_Homo sapiens_hsa050310.13893235
99Vibrio cholerae infection_Homo sapiens_hsa051100.13499521
100Linoleic acid metabolism_Homo sapiens_hsa005910.13486296

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