UBE2NL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.07993083
2central nervous system myelination (GO:0022010)6.07993083
3N-acetylglucosamine metabolic process (GO:0006044)4.60097543
4negative regulation of astrocyte differentiation (GO:0048712)4.59166862
5double-strand break repair via nonhomologous end joining (GO:0006303)4.54713437
6non-recombinational repair (GO:0000726)4.54713437
7opioid receptor signaling pathway (GO:0038003)4.54479037
8chondrocyte proliferation (GO:0035988)4.44227792
9detection of calcium ion (GO:0005513)4.39197802
10protein localization to cilium (GO:0061512)4.37195979
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.34057330
12DNA ligation (GO:0006266)4.30954940
13ATP synthesis coupled proton transport (GO:0015986)4.18312807
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.18312807
15DNA catabolic process, exonucleolytic (GO:0000738)4.16623205
16negative regulation of thymocyte apoptotic process (GO:0070244)4.11481145
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.02510081
18kynurenine metabolic process (GO:0070189)3.91683183
19telomere maintenance via telomerase (GO:0007004)3.91205357
20chromatin remodeling at centromere (GO:0031055)3.91166876
21positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.87650722
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.85182909
23regulation of thymocyte apoptotic process (GO:0070243)3.79039110
24DNA deamination (GO:0045006)3.69785392
25CENP-A containing nucleosome assembly (GO:0034080)3.68377497
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66914277
27water-soluble vitamin biosynthetic process (GO:0042364)3.65386242
28glutamate receptor signaling pathway (GO:0007215)3.61610277
29rRNA modification (GO:0000154)3.59104525
30RNA-dependent DNA replication (GO:0006278)3.58629280
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56449812
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.53912032
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.53912032
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.53912032
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.53652862
36regulation of DNA endoreduplication (GO:0032875)3.52661166
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50136964
38regulation of inositol phosphate biosynthetic process (GO:0010919)3.48253111
39negative regulation of glial cell differentiation (GO:0045686)3.47198289
40rRNA methylation (GO:0031167)3.47036795
41regulation of astrocyte differentiation (GO:0048710)3.44613210
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44392346
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44392346
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40986997
45proteasome assembly (GO:0043248)3.40920646
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39948639
47phosphorelay signal transduction system (GO:0000160)3.38991234
48protein complex biogenesis (GO:0070271)3.37600634
49regulation of chronic inflammatory response (GO:0002676)3.37390396
50regulation of cellular amino acid metabolic process (GO:0006521)3.36716028
51signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36548782
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.36548782
53behavioral response to nicotine (GO:0035095)3.36270631
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34856212
55protein K6-linked ubiquitination (GO:0085020)3.34729653
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.34694369
57serotonin metabolic process (GO:0042428)3.34509970
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33419900
59cullin deneddylation (GO:0010388)3.30877986
60DNA double-strand break processing (GO:0000729)3.26180675
61deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.25987234
62positive regulation of synapse maturation (GO:0090129)3.24848319
63intra-S DNA damage checkpoint (GO:0031573)3.24475728
64intraciliary transport (GO:0042073)3.22795454
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22400082
66negative regulation of telomere maintenance (GO:0032205)3.21778577
67postreplication repair (GO:0006301)3.21288362
68indole-containing compound catabolic process (GO:0042436)3.21219458
69indolalkylamine catabolic process (GO:0046218)3.21219458
70tryptophan catabolic process (GO:0006569)3.21219458
71negative regulation of neurotransmitter transport (GO:0051589)3.20096394
72glucosamine-containing compound metabolic process (GO:1901071)3.19655132
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17255178
74negative regulation of ligase activity (GO:0051352)3.17255178
75cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.16831043
76modulation by virus of host process (GO:0019054)3.15013580
77neuron cell-cell adhesion (GO:0007158)3.13789602
78tryptophan metabolic process (GO:0006568)3.13038605
79histone exchange (GO:0043486)3.12001007
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11823230
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11823230
82establishment of integrated proviral latency (GO:0075713)3.11699611
83synaptic transmission, glutamatergic (GO:0035249)3.10558766
84regulation of synapse maturation (GO:0090128)3.09821557
85mitochondrial respiratory chain complex assembly (GO:0033108)3.09555509
86cellular response to gamma radiation (GO:0071480)3.08103685
87negative regulation of DNA-dependent DNA replication (GO:2000104)3.08019802
88protein localization to synapse (GO:0035418)3.05175273
89protein deneddylation (GO:0000338)3.03184842
90peptidyl-histidine modification (GO:0018202)3.01796050
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01050716
92oligosaccharide catabolic process (GO:0009313)2.99940819
93chaperone-mediated protein transport (GO:0072321)2.98451585
94spliceosomal snRNP assembly (GO:0000387)2.97717737
95positive regulation of action potential (GO:0045760)2.96445336
96lens fiber cell development (GO:0070307)2.96346243
97righting reflex (GO:0060013)2.95776470
98ganglioside metabolic process (GO:0001573)2.93830011
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92701241
100negative regulation of execution phase of apoptosis (GO:1900118)2.91943864
101aldehyde catabolic process (GO:0046185)2.91792809
102lung epithelium development (GO:0060428)2.91429040
103recombinational repair (GO:0000725)2.90366476
104maturation of 5.8S rRNA (GO:0000460)2.89118859
105GTP biosynthetic process (GO:0006183)2.87754657
106positive regulation of prostaglandin secretion (GO:0032308)2.87333486
107regulation of glutamate secretion (GO:0014048)2.86969345
108omega-hydroxylase P450 pathway (GO:0097267)2.86696259
109indolalkylamine metabolic process (GO:0006586)2.85228060
110electron transport chain (GO:0022900)2.84610146
111startle response (GO:0001964)2.84491756
112respiratory electron transport chain (GO:0022904)2.84389499
113ventricular trabecula myocardium morphogenesis (GO:0003222)2.82734786
114pseudouridine synthesis (GO:0001522)2.82619637
115axon regeneration (GO:0031103)2.81913515
116double-strand break repair via homologous recombination (GO:0000724)2.81552141
117positive regulation of ligase activity (GO:0051351)2.81400626
118positive regulation of DNA repair (GO:0045739)2.81327157
119DNA replication-dependent nucleosome assembly (GO:0006335)2.79902175
120DNA replication-dependent nucleosome organization (GO:0034723)2.79902175
121pyrimidine ribonucleoside catabolic process (GO:0046133)2.78725188
122DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78589615
123spliceosomal complex assembly (GO:0000245)2.77121730
124central nervous system projection neuron axonogenesis (GO:0021952)2.76846261
125response to auditory stimulus (GO:0010996)2.76787844
126positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.76223078
127neuron projection regeneration (GO:0031102)2.75896710
128cytochrome complex assembly (GO:0017004)2.75890881
129lymphoid progenitor cell differentiation (GO:0002320)2.75642468
130adenosine metabolic process (GO:0046085)2.74537532
131organelle disassembly (GO:1903008)2.74386559
132neuronal action potential propagation (GO:0019227)2.73478504
133cilium morphogenesis (GO:0060271)2.73230930
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72210184
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.72210184
136NADH dehydrogenase complex assembly (GO:0010257)2.72210184
137purine deoxyribonucleotide catabolic process (GO:0009155)2.70655642
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70536965
139cerebral cortex radially oriented cell migration (GO:0021799)2.70280393
140regulation of isotype switching to IgG isotypes (GO:0048302)2.69194993
141presynaptic membrane assembly (GO:0097105)2.68740613
142mismatch repair (GO:0006298)2.67575067
143platelet dense granule organization (GO:0060155)2.67289910
144synapsis (GO:0007129)2.66863532
145negative regulation of neurotransmitter secretion (GO:0046929)2.66582415
146purine nucleoside triphosphate biosynthetic process (GO:0009145)2.66360991
147histone H2A acetylation (GO:0043968)2.63832602
148regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.63522491
149oligodendrocyte differentiation (GO:0048709)2.63514961
150viral mRNA export from host cell nucleus (GO:0046784)2.63081148
151DNA integration (GO:0015074)2.62948827
152negative regulation of oligodendrocyte differentiation (GO:0048715)2.62342692
153purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62287385
154deoxyribose phosphate biosynthetic process (GO:0046385)2.61854038
1552-deoxyribonucleotide biosynthetic process (GO:0009265)2.61854038
156mannosylation (GO:0097502)2.61740100
157DNA replication-independent nucleosome organization (GO:0034724)2.61672158
158DNA replication-independent nucleosome assembly (GO:0006336)2.61672158
159positive regulation of cell cycle arrest (GO:0071158)2.61444261
160primary amino compound metabolic process (GO:1901160)2.61404782
161lactate metabolic process (GO:0006089)2.60711948
162establishment of viral latency (GO:0019043)2.60293356
163positive regulation of osteoclast differentiation (GO:0045672)2.60221623
164neuron-neuron synaptic transmission (GO:0007270)2.59938391
165respiratory chain complex IV assembly (GO:0008535)2.58806428
166regulation of timing of cell differentiation (GO:0048505)2.58368722
167piRNA metabolic process (GO:0034587)2.57392326
168protein prenylation (GO:0018342)2.56959515
169prenylation (GO:0097354)2.56959515
170regulation of synaptic transmission, glutamatergic (GO:0051966)2.56603407
171Sertoli cell development (GO:0060009)2.55843914
172protein-cofactor linkage (GO:0018065)2.55072651
173ATP biosynthetic process (GO:0006754)2.54245088
174purine deoxyribonucleotide metabolic process (GO:0009151)2.53654844
175chondroitin sulfate catabolic process (GO:0030207)2.53644199
176regulation of somitogenesis (GO:0014807)2.52918643
177positive regulation of actin filament depolymerization (GO:0030836)2.51467672
178regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49441783
179urinary tract smooth muscle contraction (GO:0014848)2.47809024
180myoblast migration (GO:0051451)2.47314322
181presynaptic membrane organization (GO:0097090)2.46461480
182amyloid precursor protein catabolic process (GO:0042987)2.46204588
183kidney morphogenesis (GO:0060993)2.45643155
184positive regulation of protein homodimerization activity (GO:0090073)2.44404006
185positive regulation of synapse assembly (GO:0051965)2.43276380
186glutamate secretion (GO:0014047)2.42827221
187long-term synaptic potentiation (GO:0060291)2.42485057
188protein neddylation (GO:0045116)2.42148693
189neuronal action potential (GO:0019228)2.41528928
190regulation of telomere maintenance via telomerase (GO:0032210)2.41487937
191axon development (GO:0061564)2.40597237
192dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.40464329
193base-excision repair, AP site formation (GO:0006285)2.39947799
194regulation of protein kinase C signaling (GO:0090036)2.39914353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.17891759
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.70665209
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51388245
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.27937835
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.58573854
6GBX2_23144817_ChIP-Seq_PC3_Human3.33956256
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12107816
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06031671
9VDR_22108803_ChIP-Seq_LS180_Human2.89711334
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87769613
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85795613
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83018487
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78539097
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.75702633
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72699679
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.71507373
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.71132950
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70015011
19ZNF274_21170338_ChIP-Seq_K562_Hela2.69860229
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.64038482
21ELK1_19687146_ChIP-ChIP_HELA_Human2.63625195
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59812641
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59812641
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54795111
25VDR_23849224_ChIP-Seq_CD4+_Human2.54528324
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.54053483
27TAF15_26573619_Chip-Seq_HEK293_Human2.53906441
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44689278
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44675219
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39657519
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38324027
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38299157
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37468591
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36577660
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35594074
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.31823325
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26683232
38FOXP3_21729870_ChIP-Seq_TREG_Human2.21751270
39CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11573882
40MYC_18555785_ChIP-Seq_MESCs_Mouse2.03928659
41IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02628535
42NOTCH1_21737748_ChIP-Seq_TLL_Human2.02623802
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00602607
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.97830330
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.97060859
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93589816
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90759533
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.89362556
49EWS_26573619_Chip-Seq_HEK293_Human1.87568450
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87219437
51MYC_18940864_ChIP-ChIP_HL60_Human1.82204828
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.81268158
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80373280
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.78856905
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77815403
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76125618
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74096743
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.71846545
59FUS_26573619_Chip-Seq_HEK293_Human1.60444735
60RNF2_27304074_Chip-Seq_NSC_Mouse1.57181913
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54436432
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53977205
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52862371
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52563777
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51708675
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51249037
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50273172
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49213324
69P300_19829295_ChIP-Seq_ESCs_Human1.48492525
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.47351924
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46649588
72DCP1A_22483619_ChIP-Seq_HELA_Human1.42100354
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41108159
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.40307836
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.38891689
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.38477355
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38093995
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.36275893
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36157846
80RUNX1_27457419_Chip-Seq_LIVER_Mouse1.35916640
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35853731
82REST_21632747_ChIP-Seq_MESCs_Mouse1.35649290
83P53_22387025_ChIP-Seq_ESCs_Mouse1.35637872
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35240832
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32838278
86MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32677148
87P300_18555785_Chip-Seq_ESCs_Mouse1.32392364
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31251592
89SMAD4_21799915_ChIP-Seq_A2780_Human1.29081278
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.29059821
91TP53_22573176_ChIP-Seq_HFKS_Human1.28668546
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.27993471
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27052030
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26691806
95TTF2_22483619_ChIP-Seq_HELA_Human1.25109163
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24871296
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.24198609
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23265004
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23229046
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22551643
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.21035688
102GABP_19822575_ChIP-Seq_HepG2_Human1.19483807
103IGF1R_20145208_ChIP-Seq_DFB_Human1.19322373
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19078119
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17775809
106AR_21572438_ChIP-Seq_LNCaP_Human1.17079054
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16780113
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.16711002
109IRF1_19129219_ChIP-ChIP_H3396_Human1.15743103
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.14431446
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13013801
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12730007
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12570455
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11983580
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11678957
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.10282120
117JUN_21703547_ChIP-Seq_K562_Human1.10245938
118E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10069798
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09322400
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.08713283
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08637562
122DROSHA_22980978_ChIP-Seq_HELA_Human1.08272596
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.07916103
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06573085
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05641398
126FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04967348
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.04967348
128PU1_27457419_Chip-Seq_LIVER_Mouse1.04948587
129NANOG_19829295_ChIP-Seq_ESCs_Human1.04796471
130SOX2_19829295_ChIP-Seq_ESCs_Human1.04796471
131ELK1_22589737_ChIP-Seq_MCF10A_Human1.04482066
132ZFX_18555785_Chip-Seq_ESCs_Mouse1.04420607
133YY1_21170310_ChIP-Seq_MESCs_Mouse1.03411921
134* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02756859
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02669539
136FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02319599
137IRF8_22096565_ChIP-ChIP_GC-B_Human1.01827770
138TP53_20018659_ChIP-ChIP_R1E_Mouse1.01169060
139TP53_18474530_ChIP-ChIP_U2OS_Human1.01072929
140AR_25329375_ChIP-Seq_VCAP_Human1.00937741
141LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00551656
142HTT_18923047_ChIP-ChIP_STHdh_Human0.99879697
143ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99800696
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99431155
145MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98619001
146SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98566218
147KDM2B_26808549_Chip-Seq_REH_Human0.98110168
148ER_23166858_ChIP-Seq_MCF-7_Human0.97769425
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96415782
150AR_20517297_ChIP-Seq_VCAP_Human0.96400070
151KLF4_18555785_Chip-Seq_ESCs_Mouse0.95708963
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94364175
153CTCF_18555785_Chip-Seq_ESCs_Mouse0.94261324
154CBP_20019798_ChIP-Seq_JUKART_Human0.94156418
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94156418
156GATA3_26560356_Chip-Seq_TH2_Human0.93193711
157XRN2_22483619_ChIP-Seq_HELA_Human0.92914633
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92495154
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92413463
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92379704
161PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92365923
162SMAD_19615063_ChIP-ChIP_OVARY_Human0.92222423
163ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91768094
164AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91456733
165NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90630308
166MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90565896
167PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90050821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.57394586
2MP0003880_abnormal_central_pattern5.42576331
3MP0008875_abnormal_xenobiotic_pharmacok4.38517377
4MP0005423_abnormal_somatic_nervous3.57441281
5MP0006072_abnormal_retinal_apoptosis3.53552849
6MP0005646_abnormal_pituitary_gland3.45051523
7MP0009780_abnormal_chondrocyte_physiolo3.05977606
8MP0004859_abnormal_synaptic_plasticity2.79200963
9MP0008872_abnormal_physiological_respon2.64112587
10MP0006292_abnormal_olfactory_placode2.41846219
11MP0001188_hyperpigmentation2.41818016
12MP0004145_abnormal_muscle_electrophysio2.31158107
13MP0002138_abnormal_hepatobiliary_system2.28400847
14MP0005084_abnormal_gallbladder_morpholo2.20639340
15MP0005171_absent_coat_pigmentation2.19838690
16MP0008789_abnormal_olfactory_epithelium2.18399139
17MP0001984_abnormal_olfaction2.16954622
18MP0004270_analgesia2.16755774
19MP0003635_abnormal_synaptic_transmissio2.13626342
20MP0000015_abnormal_ear_pigmentation2.05669483
21MP0008877_abnormal_DNA_methylation2.04580275
22MP0009745_abnormal_behavioral_response2.02952667
23MP0001835_abnormal_antigen_presentation1.99267562
24MP0006276_abnormal_autonomic_nervous1.98490833
25MP0010094_abnormal_chromosome_stability1.97224262
26MP0003183_abnormal_peptide_metabolism1.95081740
27MP0003718_maternal_effect1.94470920
28MP0005394_taste/olfaction_phenotype1.93696161
29MP0005499_abnormal_olfactory_system1.93696161
30MP0010030_abnormal_orbit_morphology1.93517494
31MP0005379_endocrine/exocrine_gland_phen1.90586028
32MP0000778_abnormal_nervous_system1.90543051
33MP0003011_delayed_dark_adaptation1.85029465
34MP0001873_stomach_inflammation1.82778980
35MP0001790_abnormal_immune_system1.82086630
36MP0005387_immune_system_phenotype1.82086630
37MP0002064_seizures1.80934831
38MP0003786_premature_aging1.80550942
39MP0004381_abnormal_hair_follicle1.80265692
40MP0002822_catalepsy1.78925792
41MP0004142_abnormal_muscle_tone1.78251913
42MP0003136_yellow_coat_color1.74991418
43MP0005645_abnormal_hypothalamus_physiol1.73359485
44MP0001905_abnormal_dopamine_level1.73155098
45MP0002063_abnormal_learning/memory/cond1.72060970
46MP0001968_abnormal_touch/_nociception1.71023661
47MP0002148_abnormal_hypersensitivity_rea1.70368033
48MP0002572_abnormal_emotion/affect_behav1.70210369
49MP0002163_abnormal_gland_morphology1.68025152
50MP0001501_abnormal_sleep_pattern1.67596253
51MP0001485_abnormal_pinna_reflex1.65704199
52MP0002876_abnormal_thyroid_physiology1.64884141
53MP0002735_abnormal_chemical_nociception1.64473049
54MP0005377_hearing/vestibular/ear_phenot1.63934924
55MP0003878_abnormal_ear_physiology1.63934924
56MP0008569_lethality_at_weaning1.62822770
57MP0003195_calcinosis1.61937525
58MP0002006_tumorigenesis1.61763082
59MP0003693_abnormal_embryo_hatching1.59307159
60MP0001486_abnormal_startle_reflex1.58162213
61MP0001529_abnormal_vocalization1.57962183
62MP0002089_abnormal_postnatal_growth/wei1.54474417
63MP0000631_abnormal_neuroendocrine_gland1.51265655
64MP0002166_altered_tumor_susceptibility1.50168431
65MP0002272_abnormal_nervous_system1.44152749
66MP0003806_abnormal_nucleotide_metabolis1.43632548
67MP0000372_irregular_coat_pigmentation1.42481821
68MP0000026_abnormal_inner_ear1.41629682
69MP0004147_increased_porphyrin_level1.39918974
70MP0002736_abnormal_nociception_after1.33086856
71MP0001963_abnormal_hearing_physiology1.33020789
72MP0002184_abnormal_innervation1.29111352
73MP0002277_abnormal_respiratory_mucosa1.24735458
74MP0004858_abnormal_nervous_system1.24608935
75MP0002557_abnormal_social/conspecific_i1.23604259
76MP0000685_abnormal_immune_system1.23355386
77MP0002067_abnormal_sensory_capabilities1.21320180
78MP0001299_abnormal_eye_distance/1.19106903
79MP0005253_abnormal_eye_physiology1.18942181
80MP0008058_abnormal_DNA_repair1.18014236
81MP0003879_abnormal_hair_cell1.16355569
82MP0009697_abnormal_copulation1.15423670
83MP0001800_abnormal_humoral_immune1.14612810
84MP0003252_abnormal_bile_duct1.11480539
85MP0003186_abnormal_redox_activity1.11421108
86MP0009250_abnormal_appendicular_skeleto1.11327751
87MP0002938_white_spotting1.10957417
88MP0005257_abnormal_intraocular_pressure1.10176251
89MP0003941_abnormal_skin_development1.09627856
90MP0002638_abnormal_pupillary_reflex1.08330311
91MP0001346_abnormal_lacrimal_gland1.07275401
92MP0009333_abnormal_splenocyte_physiolog1.05620103
93MP0002734_abnormal_mechanical_nocicepti1.05172143
94MP0002928_abnormal_bile_duct1.05030891
95MP0001881_abnormal_mammary_gland1.04282595
96MP0003329_amyloid_beta_deposits1.03502493
97MP0003172_abnormal_lysosome_physiology1.01488852
98MP0003763_abnormal_thymus_physiology1.01404438
99MP0004215_abnormal_myocardial_fiber0.98877986
100MP0002282_abnormal_trachea_morphology0.98695997
101MP0004957_abnormal_blastocyst_morpholog0.95560210
102MP0009046_muscle_twitch0.94084996
103MP0001177_atelectasis0.92956002
104MP0005085_abnormal_gallbladder_physiolo0.92722432
105MP0002882_abnormal_neuron_morphology0.92587175
106MP0009764_decreased_sensitivity_to0.92228137
107MP0003938_abnormal_ear_development0.92013608
108MP0002837_dystrophic_cardiac_calcinosis0.91025807
109MP0000920_abnormal_myelination0.89645046
110MP0003866_abnormal_defecation0.89584328
111MP0002160_abnormal_reproductive_system0.88563977
112MP0001502_abnormal_circadian_rhythm0.88141143
113MP0003632_abnormal_nervous_system0.88124830
114MP0003567_abnormal_fetal_cardiomyocyte0.87985223
115MP0002233_abnormal_nose_morphology0.87783537
116MP0002751_abnormal_autonomic_nervous0.87138514
117MP0001542_abnormal_bone_strength0.86632241
118MP0002210_abnormal_sex_determination0.86068216
119MP0005451_abnormal_body_composition0.85940300
120MP0005389_reproductive_system_phenotype0.85231968
121MP0002102_abnormal_ear_morphology0.84706024
122MP0001293_anophthalmia0.84227499
123MP0000049_abnormal_middle_ear0.83706320
124MP0003119_abnormal_digestive_system0.83623627
125MP0002152_abnormal_brain_morphology0.83228944
126MP0008775_abnormal_heart_ventricle0.81914701
127MP0002723_abnormal_immune_serum0.81581904
128MP0005075_abnormal_melanosome_morpholog0.81339688
129MP0001986_abnormal_taste_sensitivity0.81298058
130MP0002095_abnormal_skin_pigmentation0.81254780
131MP0003936_abnormal_reproductive_system0.80778933
132MP0000427_abnormal_hair_cycle0.80746787
133MP0004885_abnormal_endolymph0.79939177
134MP0009384_cardiac_valve_regurgitation0.79488923
135MP0004134_abnormal_chest_morphology0.79012386
136MP0002653_abnormal_ependyma_morphology0.78684071
137MP0008873_increased_physiological_sensi0.78182964
138MP0000383_abnormal_hair_follicle0.77908831
139MP0003436_decreased_susceptibility_to0.77494392
140MP0004742_abnormal_vestibular_system0.77315445
141MP0002752_abnormal_somatic_nervous0.76907098
142MP0002733_abnormal_thermal_nociception0.76576663
143MP0004924_abnormal_behavior0.76516275
144MP0005386_behavior/neurological_phenoty0.76516275
145MP0008260_abnormal_autophagy0.75936893
146MP0000653_abnormal_sex_gland0.75844105
147MP0008007_abnormal_cellular_replicative0.75610809
148MP0005671_abnormal_response_to0.74962338
149MP0004133_heterotaxia0.73854479
150MP0000490_abnormal_crypts_of0.73515770
151MP0001958_emphysema0.73385498
152MP0000613_abnormal_salivary_gland0.73252383
153MP0010155_abnormal_intestine_physiology0.72914469
154MP0002132_abnormal_respiratory_system0.72695376
155MP0002066_abnormal_motor_capabilities/c0.72591387
156MP0000955_abnormal_spinal_cord0.72495587
157MP0005408_hypopigmentation0.72240117
158MP0001970_abnormal_pain_threshold0.72121169
159MP0006036_abnormal_mitochondrial_physio0.72024396
160MP0009785_altered_susceptibility_to0.71646144
161MP0002405_respiratory_system_inflammati0.71607349
162MP0010678_abnormal_skin_adnexa0.71149975
163MP0005551_abnormal_eye_electrophysiolog0.69098773
164MP0002452_abnormal_antigen_presenting0.68958956
165MP0002420_abnormal_adaptive_immunity0.68811288
166MP0005410_abnormal_fertilization0.68774851
167MP0003631_nervous_system_phenotype0.68758574
168MP0001929_abnormal_gametogenesis0.68589165
169MP0002933_joint_inflammation0.68468860
170MP0003075_altered_response_to0.62276942

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.11006263
2Congenital, generalized hypertrichosis (HP:0004540)4.02233598
3Increased CSF lactate (HP:0002490)3.98757394
4Hepatocellular necrosis (HP:0001404)3.79395824
53-Methylglutaconic aciduria (HP:0003535)3.77690905
6Focal motor seizures (HP:0011153)3.77292659
7Acute necrotizing encephalopathy (HP:0006965)3.58299493
8Increased hepatocellular lipid droplets (HP:0006565)3.56996798
9Osteomalacia (HP:0002749)3.52695080
10Hepatic necrosis (HP:0002605)3.50437938
11Nephronophthisis (HP:0000090)3.26614292
12Pancreatic cysts (HP:0001737)3.24202591
13Microvesicular hepatic steatosis (HP:0001414)3.23925374
14Septo-optic dysplasia (HP:0100842)3.16945158
15Spinal canal stenosis (HP:0003416)3.10630013
16Increased serum lactate (HP:0002151)3.05021848
17Retinal dysplasia (HP:0007973)3.03354456
18Abnormal mitochondria in muscle tissue (HP:0008316)2.98285051
19Methylmalonic acidemia (HP:0002912)2.97897463
20Progressive macrocephaly (HP:0004481)2.94538690
21Nephrogenic diabetes insipidus (HP:0009806)2.91571862
22Lipid accumulation in hepatocytes (HP:0006561)2.91468421
23Gait imbalance (HP:0002141)2.88487959
24Decreased circulating renin level (HP:0003351)2.88060676
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.83828237
26Congenital primary aphakia (HP:0007707)2.83589040
27Alacrima (HP:0000522)2.82773745
28Medial flaring of the eyebrow (HP:0010747)2.80136261
29Abnormality of the renal medulla (HP:0100957)2.79098657
30Acute encephalopathy (HP:0006846)2.78402917
31Epileptic encephalopathy (HP:0200134)2.77576393
32Gaze-evoked nystagmus (HP:0000640)2.76507901
33Bile duct proliferation (HP:0001408)2.76048696
34Abnormal biliary tract physiology (HP:0012439)2.76048696
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74734770
36Megalencephaly (HP:0001355)2.74261775
37Methylmalonic aciduria (HP:0012120)2.73226969
38Nasolacrimal duct obstruction (HP:0000579)2.71270838
39Abolished electroretinogram (ERG) (HP:0000550)2.68913709
40Mixed hearing impairment (HP:0000410)2.65547654
41Degeneration of anterior horn cells (HP:0002398)2.65211358
42Abnormality of the anterior horn cell (HP:0006802)2.65211358
43Abnormality of the right ventricle (HP:0001707)2.64308078
44Renal Fanconi syndrome (HP:0001994)2.63821771
45Pancreatic fibrosis (HP:0100732)2.59282460
46Hypothermia (HP:0002045)2.58466094
47Adrenal hypoplasia (HP:0000835)2.56465374
48Abnormality of the renal cortex (HP:0011035)2.53117055
49IgG deficiency (HP:0004315)2.52798193
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52367348
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52367348
52Abnormality of midbrain morphology (HP:0002418)2.52256633
53Molar tooth sign on MRI (HP:0002419)2.52256633
54Optic nerve hypoplasia (HP:0000609)2.51159505
55Increased intramyocellular lipid droplets (HP:0012240)2.50991876
56Exertional dyspnea (HP:0002875)2.50224467
57Dysdiadochokinesis (HP:0002075)2.47863345
58Aplasia involving bones of the upper limbs (HP:0009823)2.47571074
59Aplasia of the phalanges of the hand (HP:0009802)2.47571074
60Aplasia involving bones of the extremities (HP:0009825)2.47571074
61Lactic acidosis (HP:0003128)2.41196622
62Cerebral edema (HP:0002181)2.40857668
63Abnormality of the middle phalanges of the toes (HP:0010183)2.38027858
64Tubulointerstitial fibrosis (HP:0005576)2.37967604
65Decreased lacrimation (HP:0000633)2.37464766
66Polyuria (HP:0000103)2.36986403
67Absence seizures (HP:0002121)2.35562636
68Colon cancer (HP:0003003)2.34965609
69Tubular atrophy (HP:0000092)2.34566071
70Coronal craniosynostosis (HP:0004440)2.33795082
71Type II lissencephaly (HP:0007260)2.33258310
72Morphological abnormality of the inner ear (HP:0011390)2.30761375
73Abnormality of renal resorption (HP:0011038)2.29082103
74Hypoplasia of the pons (HP:0012110)2.28915312
75Adactyly (HP:0009776)2.28312599
76Attenuation of retinal blood vessels (HP:0007843)2.28122774
77Optic disc pallor (HP:0000543)2.27586482
78Abnormality of cochlea (HP:0000375)2.27150489
79Abnormality of the pons (HP:0007361)2.25706658
80Type I transferrin isoform profile (HP:0003642)2.23254081
81Abnormality of permanent molar morphology (HP:0011071)2.22807880
82Abnormality of the dental root (HP:0006486)2.22807880
83Taurodontia (HP:0000679)2.22807880
84Eczematoid dermatitis (HP:0000976)2.21718917
85Abnormality of the lacrimal duct (HP:0011481)2.21611866
86Thickened helices (HP:0000391)2.21356311
87Polydipsia (HP:0001959)2.21213424
88Abnormal drinking behavior (HP:0030082)2.21213424
89Lethargy (HP:0001254)2.20494611
90Poor coordination (HP:0002370)2.18887074
91Cerebral hypomyelination (HP:0006808)2.16661952
92Congenital stationary night blindness (HP:0007642)2.15358041
93Respiratory difficulties (HP:0002880)2.14373710
94Abnormality of alanine metabolism (HP:0010916)2.14123559
95Hyperalaninemia (HP:0003348)2.14123559
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14123559
97Progressive inability to walk (HP:0002505)2.13943530
98Hyperphosphaturia (HP:0003109)2.11816336
99Abnormality of molar (HP:0011077)2.10734251
100Abnormality of molar morphology (HP:0011070)2.10734251
101Aplasia/Hypoplasia of the lens (HP:0008063)2.10151268
102Respiratory failure (HP:0002878)2.09444190
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09347940
104Atonic seizures (HP:0010819)2.07662312
105Hyperactive renin-angiotensin system (HP:0000841)2.07331226
106Partial duplication of thumb phalanx (HP:0009944)2.06048171
107Neonatal short-limb short stature (HP:0008921)2.05466412
108Abnormal number of erythroid precursors (HP:0012131)2.05277191
109Sclerocornea (HP:0000647)2.02018594
110Constricted visual fields (HP:0001133)2.00769603
111Abnormality of the prostate (HP:0008775)1.98546556
112Prolonged partial thromboplastin time (HP:0003645)1.98244876
113Abnormality of the proximal phalanges of the hand (HP:0009834)1.96127223
114Pendular nystagmus (HP:0012043)1.95882420
115Abnormal urine phosphate concentration (HP:0012599)1.95275350
116Prostate neoplasm (HP:0100787)1.93956990
117Postaxial foot polydactyly (HP:0001830)1.93025683
118Cupped ear (HP:0000378)1.92719507
119Increased corneal curvature (HP:0100692)1.92591637
120Keratoconus (HP:0000563)1.92591637
121Glycosuria (HP:0003076)1.91692506
122Abnormality of urine glucose concentration (HP:0011016)1.91692506
123Abnormal hair whorl (HP:0010721)1.91578415
124Genital tract atresia (HP:0001827)1.90952814
125Vaginal atresia (HP:0000148)1.90859676
126Abnormality of the nasolacrimal system (HP:0000614)1.90255899
127Fair hair (HP:0002286)1.90212116
128Xerostomia (HP:0000217)1.89772952
129Conical tooth (HP:0000698)1.89666642
130Hyperaldosteronism (HP:0000859)1.87851865
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.87391114
132Stomatitis (HP:0010280)1.86581503
133Delayed CNS myelination (HP:0002188)1.86544353
134Preaxial hand polydactyly (HP:0001177)1.86419889
135True hermaphroditism (HP:0010459)1.86408005
136Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86248309
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.85857209
138Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85857209
139Epileptiform EEG discharges (HP:0011182)1.85759435
140Flared iliac wings (HP:0002869)1.85491861
141Abnormal urine output (HP:0012590)1.85245512
142Reduced antithrombin III activity (HP:0001976)1.84111267
143Inability to walk (HP:0002540)1.84050090
144Abnormality of the dental pulp (HP:0006479)1.83445412
145Growth hormone deficiency (HP:0000824)1.83301195
146Recurrent corneal erosions (HP:0000495)1.83061094
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.82341098
148Hypoplasia of the fovea (HP:0007750)1.82341098
149Abnormality of incisor morphology (HP:0011063)1.81954627
150Lissencephaly (HP:0001339)1.81735974
151Exercise intolerance (HP:0003546)1.81277079
152Oligodactyly (hands) (HP:0001180)1.80885067
153Bony spicule pigmentary retinopathy (HP:0007737)1.79725947
154Alkalosis (HP:0001948)1.79674288
155Large eyes (HP:0001090)1.79519956
156Dialeptic seizures (HP:0011146)1.79346138
157CNS demyelination (HP:0007305)1.79344300
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79046547
159Recurrent cutaneous fungal infections (HP:0011370)1.78303075
160Chronic mucocutaneous candidiasis (HP:0002728)1.78303075
161Increased muscle lipid content (HP:0009058)1.78154285
162Abnormality of vitamin B metabolism (HP:0004340)1.77646559
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77619613
164Cerebral palsy (HP:0100021)1.76868219
165Increased circulating renin level (HP:0000848)1.75141710
166Abnormality of cells of the erythroid lineage (HP:0012130)1.73626955
167Supernumerary spleens (HP:0009799)1.73579231
168Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.73393893
169Anterior segment dysgenesis (HP:0007700)1.73366400
170Bilateral microphthalmos (HP:0007633)1.73042859
171Hypoproteinemia (HP:0003075)1.72229199
172Generalized aminoaciduria (HP:0002909)1.72189926
173Focal seizures (HP:0007359)1.72105317
174Hypoplastic left heart (HP:0004383)1.71440118
175Broad foot (HP:0001769)1.68146902
176Mitochondrial inheritance (HP:0001427)1.67182841
177Infantile muscular hypotonia (HP:0008947)1.66385386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.90989096
2BUB14.70925237
3BLK3.66218296
4NUAK13.12996453
5CASK3.09384709
6PRPF4B2.99582373
7NTRK32.94014865
8TAOK22.82575245
9BMPR1B2.71253454
10EPHA42.45701141
11TSSK62.18498675
12CDK82.06818439
13NEK12.00874849
14MST41.97275210
15PBK1.88981633
16MAPK131.80488025
17TAF11.79879326
18SIK31.77668679
19EIF2AK11.73552949
20TNIK1.68472283
21TXK1.67400081
22MAP4K21.62215498
23MAP2K71.61307613
24STK391.57565240
25ARAF1.52420519
26CDK191.51924552
27FRK1.50028585
28WNK41.49562512
29TESK21.48486333
30LIMK11.46061848
31SRPK11.37668874
32STK161.37582435
33MAPK151.33909187
34KDR1.32791692
35INSRR1.32601347
36LATS21.31579893
37TRIM281.31346889
38PLK41.30501007
39BCR1.29465913
40TLK11.28917901
41EIF2AK31.27549870
42TAOK31.27291485
43BMPR21.26272013
44NME11.25710092
45CDC71.20135070
46PHKG11.14159858
47PHKG21.14159858
48SGK2231.13321802
49SGK4941.13321802
50BCKDK1.13178255
51PIK3CA1.12275166
52TESK11.11388277
53UHMK11.06760742
54ZAK1.06742958
55ADRBK21.02892589
56PIM21.01762129
57WNK30.99632180
58CSNK1G30.99387298
59CSNK1G20.98497636
60RIPK10.97424935
61GRK10.96931503
62TGFBR10.96660066
63DAPK20.96639977
64PLK20.96537317
65OXSR10.95728962
66ABL20.91603287
67CSNK1A1L0.89448820
68TTK0.88380393
69IRAK10.88298768
70NTRK20.85986294
71LMTK20.84432082
72YES10.81672769
73MINK10.81585607
74TEC0.81582830
75FGFR10.79592874
76ERBB30.79451127
77MKNK10.76505295
78CAMKK20.76211720
79DAPK10.75757638
80FGFR30.75449532
81ACVR1B0.74935040
82MKNK20.73804581
83MAPKAPK30.71972916
84RPS6KA40.70804957
85DYRK20.70188270
86SGK20.69845962
87VRK10.69828014
88PAK60.68953140
89BRAF0.68140274
90LATS10.66078406
91ITK0.65749504
92CDK180.65080803
93CAMK2B0.64664360
94CAMK2A0.63075583
95PASK0.63027535
96MARK10.62310613
97CDK140.61258181
98KIT0.60928925
99CSNK1G10.59995323
100ATR0.59458645
101PLK30.58385458
102TAOK10.58288070
103MAPKAPK50.57479221
104MAP3K140.56204526
105PTK2B0.53855325
106GRK70.53453982
107MAP2K60.52184631
108PLK10.52006932
109CDK150.51768639
110ADRBK10.50726320
111CCNB10.50208656
112IRAK20.50192944
113PINK10.48616936
114WEE10.48092889
115CDK11A0.45635548
116MAP3K120.45195380
117PRKG20.44985137
118RIPK40.44982248
119CAMKK10.44762071
120TIE10.44482805
121FGR0.44167284
122BRSK20.44009470
123PRKCE0.44003331
124STK38L0.43649744
125MUSK0.43293651
126NEK60.43212752
127AURKB0.43197225
128PRKCQ0.43119587
129PDK20.42973611
130RPS6KA50.42957519
131EIF2AK20.42582583
132CDK50.42478187
133ROCK10.42043077
134MAP2K10.41445167
135MAPK120.41339852
136DYRK30.39617454
137CSNK2A10.39298784
138GRK50.38433190
139MAP3K110.38336500
140CHEK20.37944887
141PDGFRA0.37077321
142PRKCG0.36604419
143IKBKE0.36183897
144LYN0.36077436
145PRKACA0.35884569
146PRKG10.35784059
147PNCK0.34650532
148CDK70.34587143
149ATM0.31690298
150MAP2K20.28797000
151SYK0.28300159
152CSNK2A20.27348481
153CSNK1A10.26758700
154PAK30.26692788

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.31977109
2Non-homologous end-joining_Homo sapiens_hsa034503.73528220
3Nicotine addiction_Homo sapiens_hsa050333.31710853
4Proteasome_Homo sapiens_hsa030502.69667110
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67809640
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.55987807
7Homologous recombination_Homo sapiens_hsa034402.48243115
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.41319682
9Mismatch repair_Homo sapiens_hsa034302.40144737
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39687180
11Sulfur metabolism_Homo sapiens_hsa009202.34143903
12Glutamatergic synapse_Homo sapiens_hsa047242.30193570
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25708746
14Asthma_Homo sapiens_hsa053102.14889547
15Ribosome_Homo sapiens_hsa030102.10894222
16Collecting duct acid secretion_Homo sapiens_hsa049662.04882556
17Oxidative phosphorylation_Homo sapiens_hsa001902.02400985
18Morphine addiction_Homo sapiens_hsa050322.00089052
19GABAergic synapse_Homo sapiens_hsa047271.93862757
20Protein export_Homo sapiens_hsa030601.92616007
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92486102
22Circadian entrainment_Homo sapiens_hsa047131.87101429
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84795009
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.75827572
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74041993
26Autoimmune thyroid disease_Homo sapiens_hsa053201.72250572
27Phototransduction_Homo sapiens_hsa047441.69987700
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66288618
29Synaptic vesicle cycle_Homo sapiens_hsa047211.65978229
30Other glycan degradation_Homo sapiens_hsa005111.65117720
31Graft-versus-host disease_Homo sapiens_hsa053321.58089946
32Fatty acid elongation_Homo sapiens_hsa000621.57623465
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53427615
34Basal transcription factors_Homo sapiens_hsa030221.51655911
35Propanoate metabolism_Homo sapiens_hsa006401.50215151
36Serotonergic synapse_Homo sapiens_hsa047261.49394966
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48919377
38Nucleotide excision repair_Homo sapiens_hsa034201.48524557
39Spliceosome_Homo sapiens_hsa030401.48366610
40Cocaine addiction_Homo sapiens_hsa050301.47034551
41Butanoate metabolism_Homo sapiens_hsa006501.46974217
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45026571
43Amphetamine addiction_Homo sapiens_hsa050311.43902443
44Nitrogen metabolism_Homo sapiens_hsa009101.41996350
45RNA transport_Homo sapiens_hsa030131.41270281
46Fanconi anemia pathway_Homo sapiens_hsa034601.40663022
47RNA polymerase_Homo sapiens_hsa030201.39355291
48Alzheimers disease_Homo sapiens_hsa050101.33319630
49Parkinsons disease_Homo sapiens_hsa050121.32772103
50Pyruvate metabolism_Homo sapiens_hsa006201.32744580
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.27718656
52Linoleic acid metabolism_Homo sapiens_hsa005911.24886350
53Dopaminergic synapse_Homo sapiens_hsa047281.24175610
54DNA replication_Homo sapiens_hsa030301.21625864
55Prion diseases_Homo sapiens_hsa050201.21461217
56Taste transduction_Homo sapiens_hsa047421.20910395
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17765310
58Insulin secretion_Homo sapiens_hsa049111.14522142
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13588331
60Selenocompound metabolism_Homo sapiens_hsa004501.10341818
61Type I diabetes mellitus_Homo sapiens_hsa049401.09612033
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09280965
63Tryptophan metabolism_Homo sapiens_hsa003801.07607005
64SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03722085
65One carbon pool by folate_Homo sapiens_hsa006701.00422220
66Base excision repair_Homo sapiens_hsa034100.98656261
67Pentose phosphate pathway_Homo sapiens_hsa000300.98343048
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98197527
69Peroxisome_Homo sapiens_hsa041460.98092216
70Pyrimidine metabolism_Homo sapiens_hsa002400.95227446
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94577070
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94521235
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94102388
74Vibrio cholerae infection_Homo sapiens_hsa051100.93060863
75RNA degradation_Homo sapiens_hsa030180.91306639
76Calcium signaling pathway_Homo sapiens_hsa040200.91058440
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89856659
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88698396
79Olfactory transduction_Homo sapiens_hsa047400.88351536
80Axon guidance_Homo sapiens_hsa043600.87803517
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.86913899
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.84860462
83Antigen processing and presentation_Homo sapiens_hsa046120.84398912
84Sphingolipid metabolism_Homo sapiens_hsa006000.83850398
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82965377
86Purine metabolism_Homo sapiens_hsa002300.82605669
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.81480480
88Arginine and proline metabolism_Homo sapiens_hsa003300.76820730
89Rheumatoid arthritis_Homo sapiens_hsa053230.74568312
90Arachidonic acid metabolism_Homo sapiens_hsa005900.73930781
91Phagosome_Homo sapiens_hsa041450.73929424
92Huntingtons disease_Homo sapiens_hsa050160.73768224
93Chemical carcinogenesis_Homo sapiens_hsa052040.73336441
94Renin secretion_Homo sapiens_hsa049240.70715026
95Cholinergic synapse_Homo sapiens_hsa047250.70410771
96Long-term potentiation_Homo sapiens_hsa047200.70072270
97Steroid biosynthesis_Homo sapiens_hsa001000.66870017
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66391260
99p53 signaling pathway_Homo sapiens_hsa041150.65965891
100Primary immunodeficiency_Homo sapiens_hsa053400.61898670
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60933307
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.59489879
103Hematopoietic cell lineage_Homo sapiens_hsa046400.59440084
104Cardiac muscle contraction_Homo sapiens_hsa042600.56853337
105Regulation of autophagy_Homo sapiens_hsa041400.56845150
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51152805
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50513265
108Systemic lupus erythematosus_Homo sapiens_hsa053220.50469440
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47433435
110Metabolic pathways_Homo sapiens_hsa011000.45801995
111beta-Alanine metabolism_Homo sapiens_hsa004100.45490684
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44237536
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.43570350
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43335542
115Glutathione metabolism_Homo sapiens_hsa004800.42027013
116Phenylalanine metabolism_Homo sapiens_hsa003600.41985432
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41894017
118Measles_Homo sapiens_hsa051620.41685668
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40939963
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40290153
121Allograft rejection_Homo sapiens_hsa053300.40271281
122* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40170081
123Salivary secretion_Homo sapiens_hsa049700.39611630
124Long-term depression_Homo sapiens_hsa047300.38501280
125African trypanosomiasis_Homo sapiens_hsa051430.38497774
126Vitamin digestion and absorption_Homo sapiens_hsa049770.37612176
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37152540
128Herpes simplex infection_Homo sapiens_hsa051680.36041271
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36000016
130cAMP signaling pathway_Homo sapiens_hsa040240.35996312
131Ether lipid metabolism_Homo sapiens_hsa005650.35580638
132Oocyte meiosis_Homo sapiens_hsa041140.35417747
133Alcoholism_Homo sapiens_hsa050340.35060950
134Complement and coagulation cascades_Homo sapiens_hsa046100.33426568
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.32724898
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32444088
137Oxytocin signaling pathway_Homo sapiens_hsa049210.31596948
138Epstein-Barr virus infection_Homo sapiens_hsa051690.31079182
139Retinol metabolism_Homo sapiens_hsa008300.29049002
140Fatty acid degradation_Homo sapiens_hsa000710.28164469
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28069659
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27723847
143mRNA surveillance pathway_Homo sapiens_hsa030150.27389812
144Ras signaling pathway_Homo sapiens_hsa040140.27090104
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26912790
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.26189195
147Cell cycle_Homo sapiens_hsa041100.24854737

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