UBE2NP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.84933163
2cytidine deamination (GO:0009972)7.67116917
3cytidine metabolic process (GO:0046087)7.67116917
4cytidine catabolic process (GO:0006216)7.67116917
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.79307120
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.48767755
7regulation of chronic inflammatory response (GO:0002676)5.20990829
8proteasome assembly (GO:0043248)4.75443505
9DNA double-strand break processing (GO:0000729)4.62189888
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46233654
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35070340
12ATP synthesis coupled proton transport (GO:0015986)4.35070340
13pseudouridine synthesis (GO:0001522)4.32216457
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.31525698
15regulation of activation of Janus kinase activity (GO:0010533)4.29026481
16negative regulation by host of viral transcription (GO:0043922)4.11965266
17rRNA modification (GO:0000154)4.06450134
18regulation of cellular amino acid metabolic process (GO:0006521)3.94688308
19positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.88029192
20water-soluble vitamin biosynthetic process (GO:0042364)3.83014803
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81304000
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.76449272
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.68632975
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.68632975
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.68632975
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66468968
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66468968
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62774427
29rRNA methylation (GO:0031167)3.59901392
30signal transduction involved in DNA damage checkpoint (GO:0072422)3.49811028
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.49811028
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.47090390
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.47090390
34isotype switching (GO:0045190)3.47090390
35positive regulation of defense response to virus by host (GO:0002230)3.46794919
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.45100759
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41015555
38negative regulation of ligase activity (GO:0051352)3.38118503
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38118503
40eosinophil chemotaxis (GO:0048245)3.34751885
41positive regulation of lymphocyte migration (GO:2000403)3.32386833
42negative regulation of calcium ion transport into cytosol (GO:0010523)3.32258947
43protein neddylation (GO:0045116)3.29451430
44positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26498262
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.25750590
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22469498
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18928277
48positive regulation of endothelial cell differentiation (GO:0045603)3.14813814
49positive regulation of ligase activity (GO:0051351)3.14808485
50positive regulation of T cell migration (GO:2000406)3.14449945
51electron transport chain (GO:0022900)3.12165101
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09055401
53GTP biosynthetic process (GO:0006183)3.07951090
54respiratory electron transport chain (GO:0022904)3.07482739
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07156275
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07156275
57sequestering of actin monomers (GO:0042989)3.04309002
58chaperone-mediated protein transport (GO:0072321)3.01982624
59eosinophil migration (GO:0072677)3.01329062
60pyrimidine ribonucleoside metabolic process (GO:0046131)2.99296420
61regulation of T cell chemotaxis (GO:0010819)2.94754991
62positive regulation of T cell chemotaxis (GO:0010820)2.94754991
63modulation by host of symbiont transcription (GO:0052472)2.94610902
64modulation by host of viral transcription (GO:0043921)2.94610902
65folic acid-containing compound biosynthetic process (GO:0009396)2.94213984
66DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.93814708
67pyrimidine nucleoside catabolic process (GO:0046135)2.93681297
68modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.87849444
69inner mitochondrial membrane organization (GO:0007007)2.87450743
70purine deoxyribonucleotide catabolic process (GO:0009155)2.83234059
71platelet dense granule organization (GO:0060155)2.83037185
72peptidyl-histidine modification (GO:0018202)2.82787053
73positive regulation of cell cycle arrest (GO:0071158)2.79887272
74cullin deneddylation (GO:0010388)2.79744319
75regulation of cellular amine metabolic process (GO:0033238)2.78748826
76regulation of endothelial cell differentiation (GO:0045601)2.78410712
77positive regulation of calcium-mediated signaling (GO:0050850)2.78378914
78regulation of chemokine-mediated signaling pathway (GO:0070099)2.77426100
79positive regulation of interleukin-8 secretion (GO:2000484)2.76992304
80positive regulation of T cell apoptotic process (GO:0070234)2.76588263
81negative regulation of viral genome replication (GO:0045071)2.76009056
82phosphatidylinositol acyl-chain remodeling (GO:0036149)2.74494656
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74141035
84DNA demethylation (GO:0080111)2.73336873
85regulation of lymphocyte chemotaxis (GO:1901623)2.72753540
86termination of RNA polymerase III transcription (GO:0006386)2.70590631
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.70590631
88activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.70027624
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69907945
90regulation of ubiquitin-protein transferase activity (GO:0051438)2.67947846
91negative regulation of telomere maintenance (GO:0032205)2.67889610
92protein deneddylation (GO:0000338)2.66998404
93maturation of 5.8S rRNA (GO:0000460)2.65603375
94regulation of inflammatory response to antigenic stimulus (GO:0002861)2.64544936
95vitamin biosynthetic process (GO:0009110)2.60869560
96regulation of ligase activity (GO:0051340)2.60742074
97antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59258851
98nucleoside diphosphate catabolic process (GO:0009134)2.58424617
99protein complex biogenesis (GO:0070271)2.58387692
100negative regulation of T cell apoptotic process (GO:0070233)2.56007389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.42965740
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.82287555
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26783738
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.93062277
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.71468962
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.70096790
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35015415
8VDR_22108803_ChIP-Seq_LS180_Human2.78435041
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.61591266
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59617637
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59400298
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51693015
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46205805
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40786310
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31508537
16VDR_23849224_ChIP-Seq_CD4+_Human2.29438667
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.24283136
18ELK1_19687146_ChIP-ChIP_HELA_Human2.14445900
19FOXP3_21729870_ChIP-Seq_TREG_Human2.03591317
20ZNF274_21170338_ChIP-Seq_K562_Hela1.99639918
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97580208
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91672398
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.87626482
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85746450
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.81209093
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71360702
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.70884374
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68781583
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65536164
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.59677480
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57714051
32IRF1_19129219_ChIP-ChIP_H3396_Human1.55631648
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51024377
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49455332
35EWS_26573619_Chip-Seq_HEK293_Human1.48152969
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48148490
37GATA3_26560356_Chip-Seq_TH2_Human1.44463396
38IGF1R_20145208_ChIP-Seq_DFB_Human1.43794249
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42119098
40MYC_18940864_ChIP-ChIP_HL60_Human1.41758646
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39290397
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36009029
43TP53_22573176_ChIP-Seq_HFKS_Human1.34490917
44P300_19829295_ChIP-Seq_ESCs_Human1.26431948
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23415599
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.21924271
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21924271
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16657154
49NANOG_19829295_ChIP-Seq_ESCs_Human1.14270966
50SOX2_19829295_ChIP-Seq_ESCs_Human1.14270966
51AR_20517297_ChIP-Seq_VCAP_Human1.13473575
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12967766
53TAF2_19829295_ChIP-Seq_ESCs_Human1.11242067
54ER_23166858_ChIP-Seq_MCF-7_Human1.10951191
55BCAT_22108803_ChIP-Seq_LS180_Human1.09631286
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09517408
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.09398057
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09224994
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09093459
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.08680141
61DCP1A_22483619_ChIP-Seq_HELA_Human1.08003052
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06896543
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06314362
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06202661
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.05280663
66FOXH1_21741376_ChIP-Seq_EPCs_Human1.04768170
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04725737
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02652291
69ERG_20517297_ChIP-Seq_VCAP_Human1.02584065
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00913964
71MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99802505
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98914376
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98367560
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97243920
75NANOG_20526341_ChIP-Seq_ESCs_Human0.97107257
76ELK1_22589737_ChIP-Seq_MCF10A_Human0.95969089
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.95813595
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95199085
79FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95122477
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94490302
81GATA3_27048872_Chip-Seq_THYMUS_Human0.93934242
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93651237
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.92764695
84MYB_26560356_Chip-Seq_TH2_Human0.92630425
85GABP_19822575_ChIP-Seq_HepG2_Human0.91417441
86TCF4_22108803_ChIP-Seq_LS180_Human0.90697325
87HOXB7_26014856_ChIP-Seq_BT474_Human0.87244109
88YY1_21170310_ChIP-Seq_MESCs_Mouse0.86404926
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86024093
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85976682
91MYC_19829295_ChIP-Seq_ESCs_Human0.85941074
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85766672
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.85231484
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85135201
95STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84137061
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83856407
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83022932
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82344199
99NCOR_22424771_ChIP-Seq_293T_Human0.81840009
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.81568432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.61655144
2MP0005671_abnormal_response_to4.34984759
3MP0001835_abnormal_antigen_presentation3.54373860
4MP0002102_abnormal_ear_morphology2.64622906
5MP0000685_abnormal_immune_system2.56947027
6MP0003693_abnormal_embryo_hatching2.54646064
7MP0003195_calcinosis2.50001153
8MP0009785_altered_susceptibility_to2.49936974
9MP0000015_abnormal_ear_pigmentation2.47603488
10MP0002148_abnormal_hypersensitivity_rea2.42934779
11MP0004145_abnormal_muscle_electrophysio2.39541347
12MP0009333_abnormal_splenocyte_physiolog2.35211638
13MP0008877_abnormal_DNA_methylation2.29208909
14MP0002166_altered_tumor_susceptibility2.29152255
15MP0005174_abnormal_tail_pigmentation2.25363752
16MP0008875_abnormal_xenobiotic_pharmacok2.15142677
17MP0006292_abnormal_olfactory_placode2.09049804
18MP0001800_abnormal_humoral_immune2.03044197
19MP0001501_abnormal_sleep_pattern1.98467854
20MP0002006_tumorigenesis1.92869431
21MP0003786_premature_aging1.88132197
22MP0005387_immune_system_phenotype1.87835641
23MP0001790_abnormal_immune_system1.87835641
24MP0005000_abnormal_immune_tolerance1.82672239
25MP0006072_abnormal_retinal_apoptosis1.73102719
26MP0002138_abnormal_hepatobiliary_system1.71555002
27MP0002653_abnormal_ependyma_morphology1.70743510
28MP0005075_abnormal_melanosome_morpholog1.70656933
29MP0005408_hypopigmentation1.65642828
30MP0002277_abnormal_respiratory_mucosa1.61218435
31MP0003186_abnormal_redox_activity1.55601567
32MP0000372_irregular_coat_pigmentation1.54199553
33MP0002723_abnormal_immune_serum1.49382338
34MP0009379_abnormal_foot_pigmentation1.46360926
35MP0005645_abnormal_hypothalamus_physiol1.44852785
36MP0008872_abnormal_physiological_respon1.42548511
37MP0002420_abnormal_adaptive_immunity1.41739093
38MP0003436_decreased_susceptibility_to1.39405668
39MP0004957_abnormal_blastocyst_morpholog1.38191603
40MP0001919_abnormal_reproductive_system1.35818223
41MP0009764_decreased_sensitivity_to1.35807305
42MP0006036_abnormal_mitochondrial_physio1.33966942
43MP0002452_abnormal_antigen_presenting1.32479888
44MP0005464_abnormal_platelet_physiology1.32156589
45MP0001819_abnormal_immune_cell1.31849473
46MP0008058_abnormal_DNA_repair1.30939050
47MP0005551_abnormal_eye_electrophysiolog1.26913090
48MP0002095_abnormal_skin_pigmentation1.25623762
49MP0005025_abnormal_response_to1.24791887
50MP0002837_dystrophic_cardiac_calcinosis1.23585754
51MP0001986_abnormal_taste_sensitivity1.22104840
52MP0002876_abnormal_thyroid_physiology1.20730149
53MP0003718_maternal_effect1.20415056
54MP0003646_muscle_fatigue1.19027514
55MP0002398_abnormal_bone_marrow1.16776273
56MP0003172_abnormal_lysosome_physiology1.14715590
57MP0005389_reproductive_system_phenotype1.12638150
58MP0009697_abnormal_copulation1.08686853
59MP0003011_delayed_dark_adaptation1.08302683
60MP0005084_abnormal_gallbladder_morpholo1.06531329
61MP0005085_abnormal_gallbladder_physiolo1.04191181
62MP0002163_abnormal_gland_morphology1.02575958
63MP0000716_abnormal_immune_system1.02575052
64MP0008995_early_reproductive_senescence1.01738538
65MP0003880_abnormal_central_pattern1.01540446
66MP0000689_abnormal_spleen_morphology1.01070558
67MP0003252_abnormal_bile_duct0.99110866
68MP0002405_respiratory_system_inflammati0.97378636
69MP0009745_abnormal_behavioral_response0.96197372
70MP0002938_white_spotting0.95221530
71MP0001293_anophthalmia0.92847697
72MP0004142_abnormal_muscle_tone0.91715830
73MP0006082_CNS_inflammation0.91570961
74MP0000371_diluted_coat_color0.91533393
75MP0010094_abnormal_chromosome_stability0.88002878
76MP0002429_abnormal_blood_cell0.85517247
77MP0002736_abnormal_nociception_after0.85365853
78MP0001905_abnormal_dopamine_level0.85157645
79MP0006035_abnormal_mitochondrial_morpho0.85123107
80MP0002272_abnormal_nervous_system0.84448682
81MP0001968_abnormal_touch/_nociception0.82546183
82MP0001845_abnormal_inflammatory_respons0.82089959
83MP0005636_abnormal_mineral_homeostasis0.77913591
84MP0000703_abnormal_thymus_morphology0.77730743
85MP0010155_abnormal_intestine_physiology0.76443360
86MP0005379_endocrine/exocrine_gland_phen0.76398870
87MP0005253_abnormal_eye_physiology0.75914939
88MP0001765_abnormal_ion_homeostasis0.75895656
89MP0008007_abnormal_cellular_replicative0.75455819
90MP0003137_abnormal_impulse_conducting0.73352372
91MP0002160_abnormal_reproductive_system0.69576510
92MP0006276_abnormal_autonomic_nervous0.68937956
93MP0005365_abnormal_bile_salt0.68749371
94MP0005332_abnormal_amino_acid0.68216438
95MP0002419_abnormal_innate_immunity0.68018870
96MP0003763_abnormal_thymus_physiology0.67411144
97MP0004019_abnormal_vitamin_homeostasis0.65872371
98MP0002722_abnormal_immune_system0.65113515
99MP0002693_abnormal_pancreas_physiology0.63191421
100MP0004742_abnormal_vestibular_system0.62292444

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.66349044
2Increased IgM level (HP:0003496)4.33024860
3IgG deficiency (HP:0004315)4.05808007
43-Methylglutaconic aciduria (HP:0003535)3.78100749
5T lymphocytopenia (HP:0005403)3.31727502
6Abnormality of T cell number (HP:0011839)3.21077344
7Fair hair (HP:0002286)3.20570389
8Pancreatic fibrosis (HP:0100732)3.14040937
9Pancreatic cysts (HP:0001737)3.12862738
10Acute necrotizing encephalopathy (HP:0006965)3.10929386
11Mitochondrial inheritance (HP:0001427)3.08668356
12Abnormality of T cells (HP:0002843)3.08412518
13Colon cancer (HP:0003003)3.07299468
14Abolished electroretinogram (ERG) (HP:0000550)3.01602968
15Elevated erythrocyte sedimentation rate (HP:0003565)2.98531766
16Increased CSF lactate (HP:0002490)2.95882776
17Aplastic anemia (HP:0001915)2.91218365
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90783497
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90783497
20Hypoproteinemia (HP:0003075)2.88600565
21Lipid accumulation in hepatocytes (HP:0006561)2.86185524
22Nephronophthisis (HP:0000090)2.84775238
23Abnormality of T cell physiology (HP:0011840)2.83146950
24Albinism (HP:0001022)2.82527081
25Hepatocellular necrosis (HP:0001404)2.80301887
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77878747
27Abnormality of alanine metabolism (HP:0010916)2.77878747
28Hyperalaninemia (HP:0003348)2.77878747
29Increased hepatocellular lipid droplets (HP:0006565)2.72726181
30Abnormal mitochondria in muscle tissue (HP:0008316)2.72526687
31Increased serum lactate (HP:0002151)2.68837770
32Increased intramyocellular lipid droplets (HP:0012240)2.65107712
33Chronic diarrhea (HP:0002028)2.65099847
34Encephalitis (HP:0002383)2.62288408
35Methylmalonic acidemia (HP:0002912)2.61648254
36Tubular atrophy (HP:0000092)2.52877973
37Progressive macrocephaly (HP:0004481)2.52267518
38True hermaphroditism (HP:0010459)2.51220823
39IgA deficiency (HP:0002720)2.50568443
40Parakeratosis (HP:0001036)2.50468508
41Hypoplasia of the pons (HP:0012110)2.50377902
42Pendular nystagmus (HP:0012043)2.46822664
43Hepatic necrosis (HP:0002605)2.45752375
44Panhypogammaglobulinemia (HP:0003139)2.45489813
45Generalized hypopigmentation of hair (HP:0011358)2.45072587
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.44549155
47Spontaneous hematomas (HP:0007420)2.42964901
48Oral leukoplakia (HP:0002745)2.42591189
49Abnormality of the renal medulla (HP:0100957)2.40449386
50Increased muscle lipid content (HP:0009058)2.40088530
51Pancytopenia (HP:0001876)2.38959448
52Molar tooth sign on MRI (HP:0002419)2.38567626
53Abnormality of midbrain morphology (HP:0002418)2.38567626
54Exertional dyspnea (HP:0002875)2.36509050
55Type I transferrin isoform profile (HP:0003642)2.36181557
56Acute encephalopathy (HP:0006846)2.35549485
57Recurrent viral infections (HP:0004429)2.30954800
58Cerebral edema (HP:0002181)2.28373831
59Abnormality of the pons (HP:0007361)2.26596057
60Renal Fanconi syndrome (HP:0001994)2.26504968
61Methylmalonic aciduria (HP:0012120)2.24209555
62Decreased central vision (HP:0007663)2.15576500
63Attenuation of retinal blood vessels (HP:0007843)2.13649099
64Amniotic constriction ring (HP:0009775)2.12531154
65Abnormality of placental membranes (HP:0011409)2.12531154
66Congenital stationary night blindness (HP:0007642)2.10398610
67Thyroid-stimulating hormone excess (HP:0002925)2.09230512
68Abnormality of vitamin B metabolism (HP:0004340)2.08799738
69Supernumerary spleens (HP:0009799)2.08373410
70Abnormality of the renal cortex (HP:0011035)2.06731126
71Abnormality of macular pigmentation (HP:0008002)2.06720477
72Reduced antithrombin III activity (HP:0001976)2.01670630
73Abnormality of the labia minora (HP:0012880)2.01013176
74Lactic acidosis (HP:0003128)1.98608242
75Homocystinuria (HP:0002156)1.98054901
76Abnormality of homocysteine metabolism (HP:0010919)1.98054901
77Neutropenia (HP:0001875)1.97435855
78Thyroiditis (HP:0100646)1.96566012
79Optic disc pallor (HP:0000543)1.96037587
80Polydipsia (HP:0001959)1.95790003
81Abnormal drinking behavior (HP:0030082)1.95790003
82Abnormality of renal resorption (HP:0011038)1.95501220
83Abnormality of the vitamin B12 metabolism (HP:0004341)1.94507529
84Respiratory failure (HP:0002878)1.91307991
85Sclerocornea (HP:0000647)1.91262802
86Cerebral hemorrhage (HP:0001342)1.90887199
87Severe combined immunodeficiency (HP:0004430)1.88695356
88Type 2 muscle fiber atrophy (HP:0003554)1.88390254
89Lethargy (HP:0001254)1.87872508
90Myositis (HP:0100614)1.85236577
91Abnormality of B cell number (HP:0010975)1.84358550
92Leukodystrophy (HP:0002415)1.81576860
93Lymphoma (HP:0002665)1.81419600
94Autoimmune hemolytic anemia (HP:0001890)1.80282937
95Cutaneous melanoma (HP:0012056)1.76523485
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75948773
97Agammaglobulinemia (HP:0004432)1.73955440
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72886518
99Melanoma (HP:0002861)1.72143103
100Hypomagnesemia (HP:0002917)1.70973434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.83197287
2VRK23.62280920
3TAF12.86404131
4MAP3K122.85943562
5WNK42.80183876
6MAP4K22.66639117
7NUAK12.58021930
8ADRBK22.57634977
9BUB12.46208899
10TAOK32.45903456
11OXSR12.40512224
12STK392.34263332
13DAPK22.20885293
14KDR2.11463259
15EIF2AK32.00713209
16PIK3CG1.98965695
17TESK21.97373490
18GRK11.95916147
19VRK11.90092706
20ZAK1.79902650
21BMPR21.69565791
22TLK11.55082081
23TXK1.52119974
24IKBKB1.45166633
25CCNB11.38767815
26WNK31.38057979
27FRK1.34225539
28MYLK1.30791718
29PLK31.17991346
30EIF2AK11.17471351
31BCKDK1.11039394
32PLK21.10896585
33TSSK61.06509939
34BMPR1B1.01936164
35ITK0.99603485
36DAPK10.99599454
37ILK0.98400386
38PLK40.96336721
39TEC0.91501084
40GRK50.89442207
41NEK10.85098597
42CDC70.80342687
43NME10.76661925
44MAP2K60.75966177
45INSRR0.74492689
46DAPK30.72780907
47SIK30.72147977
48PTK2B0.68087327
49PDK20.65744194
50AURKB0.65421582
51TRIM280.63564680
52ALK0.62775210
53IKBKE0.62712831
54EIF2AK20.61398923
55CLK10.60902247
56PAK30.60099477
57GRK60.59890792
58TESK10.59464013
59MAPKAPK50.59243234
60CDK190.58681663
61STK160.58671773
62ATR0.58364757
63SYK0.58097905
64DYRK20.57267611
65SRPK10.57249300
66STK40.57129045
67RIPK40.56121251
68TIE10.55410353
69LCK0.55265117
70GRK70.53394019
71LIMK10.52646129
72CAMK10.52088452
73PRKCQ0.51452560
74FES0.50760987
75OBSCN0.49695963
76PLK10.46727164
77BRD40.45916957
78CAMK2A0.44902164
79SMG10.44343957
80PRKCE0.43811209
81CSNK1G30.43638154
82CHUK0.41506606
83PRKCI0.40650866
84FGFR10.39266225
85CDK70.38793275
86ADRBK10.38323394
87MKNK20.37977060
88WEE10.36888244
89AURKA0.36646865
90CAMKK20.36124280
91CAMK40.35947023
92RPS6KA50.35416588
93MAP4K10.34058141
94RPS6KA40.33992799
95CAMK2D0.33085220
96CSNK1G10.32576415
97BCR0.32334502
98CSNK2A10.31545874
99PRKACA0.30467601
100PAK40.30410852

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.52113854
2Oxidative phosphorylation_Homo sapiens_hsa001903.19124122
3Primary immunodeficiency_Homo sapiens_hsa053403.14156550
4Protein export_Homo sapiens_hsa030602.92296651
5Parkinsons disease_Homo sapiens_hsa050122.89257755
6Asthma_Homo sapiens_hsa053102.53933239
7RNA polymerase_Homo sapiens_hsa030202.52358541
8Allograft rejection_Homo sapiens_hsa053302.42625096
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38911749
10One carbon pool by folate_Homo sapiens_hsa006702.24445565
11Autoimmune thyroid disease_Homo sapiens_hsa053202.20853131
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.20804547
13Linoleic acid metabolism_Homo sapiens_hsa005912.19391335
14Vitamin B6 metabolism_Homo sapiens_hsa007502.12751122
15Type I diabetes mellitus_Homo sapiens_hsa049402.06841640
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01278817
17Non-homologous end-joining_Homo sapiens_hsa034501.90492593
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89302566
19Ribosome_Homo sapiens_hsa030101.87665498
20Alzheimers disease_Homo sapiens_hsa050101.87005174
21Huntingtons disease_Homo sapiens_hsa050161.84521306
22Antigen processing and presentation_Homo sapiens_hsa046121.79056519
23Graft-versus-host disease_Homo sapiens_hsa053321.67970758
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60110955
25Homologous recombination_Homo sapiens_hsa034401.43002777
26RNA degradation_Homo sapiens_hsa030181.33442248
27Rheumatoid arthritis_Homo sapiens_hsa053231.28928031
28Cardiac muscle contraction_Homo sapiens_hsa042601.27342553
29Mismatch repair_Homo sapiens_hsa034301.24620887
30RNA transport_Homo sapiens_hsa030131.16494158
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14187589
32Phototransduction_Homo sapiens_hsa047441.12992507
33Caffeine metabolism_Homo sapiens_hsa002321.11522122
34Propanoate metabolism_Homo sapiens_hsa006401.10354649
35Ether lipid metabolism_Homo sapiens_hsa005651.05527446
36T cell receptor signaling pathway_Homo sapiens_hsa046601.05128558
37Arachidonic acid metabolism_Homo sapiens_hsa005901.04282923
38DNA replication_Homo sapiens_hsa030301.03690788
39Pyrimidine metabolism_Homo sapiens_hsa002401.02774176
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02209955
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99564687
42Basal transcription factors_Homo sapiens_hsa030220.97459904
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96328033
44Nucleotide excision repair_Homo sapiens_hsa034200.96102141
45Tryptophan metabolism_Homo sapiens_hsa003800.95636858
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94531404
47beta-Alanine metabolism_Homo sapiens_hsa004100.87009934
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.86360263
49Purine metabolism_Homo sapiens_hsa002300.85174225
50Peroxisome_Homo sapiens_hsa041460.83408655
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83199721
52Hematopoietic cell lineage_Homo sapiens_hsa046400.81128012
53Viral myocarditis_Homo sapiens_hsa054160.79690098
54Fanconi anemia pathway_Homo sapiens_hsa034600.72057904
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70890658
56Sulfur metabolism_Homo sapiens_hsa009200.67502211
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62604221
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61901412
59Spliceosome_Homo sapiens_hsa030400.60569399
60Retinol metabolism_Homo sapiens_hsa008300.59682454
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56003135
62Fatty acid degradation_Homo sapiens_hsa000710.55415364
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54973288
64Regulation of autophagy_Homo sapiens_hsa041400.53082943
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52544739
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.49176919
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.48940849
68Metabolic pathways_Homo sapiens_hsa011000.44035659
69Mineral absorption_Homo sapiens_hsa049780.43690676
70Legionellosis_Homo sapiens_hsa051340.42751370
71Measles_Homo sapiens_hsa051620.41143443
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39321204
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.38922994
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.35888796
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35208280
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34003392
77Systemic lupus erythematosus_Homo sapiens_hsa053220.33846409
78Fatty acid elongation_Homo sapiens_hsa000620.33394514
79Ovarian steroidogenesis_Homo sapiens_hsa049130.33067106
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32455875
81Steroid biosynthesis_Homo sapiens_hsa001000.31946624
82Serotonergic synapse_Homo sapiens_hsa047260.31554343
83Chemical carcinogenesis_Homo sapiens_hsa052040.30908778
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30866895
85Epstein-Barr virus infection_Homo sapiens_hsa051690.30434143
86Butanoate metabolism_Homo sapiens_hsa006500.29780722
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29389290
88Glycerolipid metabolism_Homo sapiens_hsa005610.27822502
89Staphylococcus aureus infection_Homo sapiens_hsa051500.27762576
90Morphine addiction_Homo sapiens_hsa050320.27458021
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24081509
92N-Glycan biosynthesis_Homo sapiens_hsa005100.23638292
93Glutathione metabolism_Homo sapiens_hsa004800.23047171
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22694483
95Herpes simplex infection_Homo sapiens_hsa051680.22497733
96Pyruvate metabolism_Homo sapiens_hsa006200.22196485
97Olfactory transduction_Homo sapiens_hsa047400.22110975
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21996501
99Salmonella infection_Homo sapiens_hsa051320.21612396
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21609770

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