UBE2O

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.86217228
2protoporphyrinogen IX metabolic process (GO:0046501)5.71283917
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55713193
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15148630
5DNA unwinding involved in DNA replication (GO:0006268)5.13861908
6locomotory exploration behavior (GO:0035641)5.05185379
7protoporphyrinogen IX biosynthetic process (GO:0006782)4.81987069
8layer formation in cerebral cortex (GO:0021819)4.71557776
9cytoskeletal anchoring at plasma membrane (GO:0007016)4.36554325
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.30511133
11glutamate secretion (GO:0014047)4.29850798
12regulation of translational fidelity (GO:0006450)4.27272170
13regulation of synaptic vesicle exocytosis (GO:2000300)4.27084570
14negative regulation of histone methylation (GO:0031061)4.21027511
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.17452748
16mitotic chromosome condensation (GO:0007076)4.17238196
17synaptic vesicle exocytosis (GO:0016079)4.06278980
18vocalization behavior (GO:0071625)4.05891129
19heterochromatin organization (GO:0070828)4.02947329
20regulation of RNA export from nucleus (GO:0046831)3.95152860
21nuclear pore complex assembly (GO:0051292)3.94631159
22protein-DNA complex disassembly (GO:0032986)3.94482159
23nucleosome disassembly (GO:0006337)3.94482159
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.89660640
25sodium ion export (GO:0071436)3.74107185
26exploration behavior (GO:0035640)3.72345471
27porphyrin-containing compound biosynthetic process (GO:0006779)3.69932886
28regulation of synaptic vesicle transport (GO:1902803)3.69191379
29cell migration in hindbrain (GO:0021535)3.68895044
30proline transport (GO:0015824)3.67261782
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66351165
32regulation of glutamate receptor signaling pathway (GO:1900449)3.65339567
33neurotransmitter secretion (GO:0007269)3.61837419
34spliceosomal tri-snRNP complex assembly (GO:0000244)3.61820765
35regulation of nucleobase-containing compound transport (GO:0032239)3.59866153
36activation of protein kinase A activity (GO:0034199)3.57650068
37regulation of neuronal synaptic plasticity (GO:0048168)3.56888700
38nuclear pore organization (GO:0006999)3.53598568
39protein localization to synapse (GO:0035418)3.52877340
40regulation of chromatin binding (GO:0035561)3.52282041
41DNA replication initiation (GO:0006270)3.49360005
42positive regulation of synapse maturation (GO:0090129)3.49208160
43regulation of mammary gland epithelial cell proliferation (GO:0033599)3.48936691
44glycine transport (GO:0015816)3.48133319
45neuromuscular process controlling balance (GO:0050885)3.47672480
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45958105
47regulation of clathrin-mediated endocytosis (GO:2000369)3.43212140
48dendritic spine morphogenesis (GO:0060997)3.41197745
49DNA topological change (GO:0006265)3.37671044
50pre-miRNA processing (GO:0031054)3.35452802
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35240255
52mitotic sister chromatid segregation (GO:0000070)3.33495934
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.33012021
54DNA strand elongation involved in DNA replication (GO:0006271)3.32697560
55regulation of synapse structural plasticity (GO:0051823)3.28307420
56regulation of ARF protein signal transduction (GO:0032012)3.26930423
57synaptic vesicle endocytosis (GO:0048488)3.26706973
58cerebellar Purkinje cell differentiation (GO:0021702)3.25299944
59positive regulation of fibroblast migration (GO:0010763)3.24479713
60cell communication by electrical coupling (GO:0010644)3.21596113
61cellular potassium ion homeostasis (GO:0030007)3.20696926
62tetrapyrrole biosynthetic process (GO:0033014)3.20679437
63sister chromatid segregation (GO:0000819)3.18299819
64mRNA stabilization (GO:0048255)3.18047792
65RNA stabilization (GO:0043489)3.18047792
66DNA strand elongation (GO:0022616)3.17923375
67protein complex localization (GO:0031503)3.17404838
68cerebellar Purkinje cell layer development (GO:0021680)3.16947856
69neuromuscular process controlling posture (GO:0050884)3.15937077
70response to methylmercury (GO:0051597)3.14466473
71intracellular estrogen receptor signaling pathway (GO:0030520)3.10733639
72neuronal action potential propagation (GO:0019227)3.09548696
73gamma-aminobutyric acid transport (GO:0015812)3.08480622
74glucocorticoid receptor signaling pathway (GO:0042921)3.08376539
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06654348
76histone H3-K36 demethylation (GO:0070544)3.06495356
77neuron cell-cell adhesion (GO:0007158)3.05033718
78negative regulation of mRNA metabolic process (GO:1903312)3.04156077
79response to insecticide (GO:0017085)3.02717541
80vesicle transport along microtubule (GO:0047496)3.01467603
81actin filament capping (GO:0051693)3.00893236
82proline biosynthetic process (GO:0006561)2.99791041
83DNA duplex unwinding (GO:0032508)2.98635167
84negative regulation of mRNA processing (GO:0050686)2.97130898
85regulation of translational termination (GO:0006449)2.95951662
86negative regulation of microtubule polymerization (GO:0031115)2.95685116
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94918189
88ribosomal small subunit biogenesis (GO:0042274)2.94730157
89positive regulation of gene expression, epigenetic (GO:0045815)2.93919318
90cerebellar granule cell differentiation (GO:0021707)2.92868218
91organelle transport along microtubule (GO:0072384)2.92612916
92peptidyl-arginine omega-N-methylation (GO:0035247)2.92382748
93mitotic sister chromatid cohesion (GO:0007064)2.91904203
94protein export from nucleus (GO:0006611)2.89885593
95negative regulation of organelle assembly (GO:1902116)2.88341172
96establishment of nucleus localization (GO:0040023)2.88081614
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88025081
98mitochondrion transport along microtubule (GO:0047497)2.88025081
99hemoglobin metabolic process (GO:0020027)2.86986252
100maturation of SSU-rRNA (GO:0030490)2.86442853
101planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84510544
102dendrite morphogenesis (GO:0048813)2.84062429
103heme biosynthetic process (GO:0006783)2.83057581
104chromatin assembly (GO:0031497)2.82646124
105positive regulation of cell cycle G2/M phase transition (GO:1902751)2.81089428
106positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.81089428
107neurotransmitter transport (GO:0006836)2.80138205
108DNA geometric change (GO:0032392)2.79456331
109long-term memory (GO:0007616)2.79248508
110synaptic transmission, glutamatergic (GO:0035249)2.79057732
111clathrin coat assembly (GO:0048268)2.78383249
112regulation of dendritic spine morphogenesis (GO:0061001)2.78128754
113positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.77777921
114regulation of histone H3-K9 methylation (GO:0051570)2.77245655
115regulation of ARF GTPase activity (GO:0032312)2.76300510
116membrane depolarization during action potential (GO:0086010)2.72894623
117membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72606570
118activation of Rac GTPase activity (GO:0032863)2.72164217
119regulation of NFAT protein import into nucleus (GO:0051532)2.72127234
120pore complex assembly (GO:0046931)2.71535765
121glutamate receptor signaling pathway (GO:0007215)2.71519659
122chromatin silencing (GO:0006342)2.71447002
123cellular protein complex localization (GO:0034629)2.71325639
124stress granule assembly (GO:0034063)2.70830421
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.69493506
126adherens junction assembly (GO:0034333)2.69428269
127telomere maintenance via semi-conservative replication (GO:0032201)2.69014665
128histone arginine methylation (GO:0034969)2.68517575
129negative regulation of histone modification (GO:0031057)2.66837466
1303-UTR-mediated mRNA stabilization (GO:0070935)2.66489485
131neuron recognition (GO:0008038)2.66209055
132regulation of synaptic plasticity (GO:0048167)2.65812810
133neuromuscular process (GO:0050905)2.63967752
134axon cargo transport (GO:0008088)2.63691934
135prepulse inhibition (GO:0060134)2.62776343
136positive regulation of membrane potential (GO:0045838)2.62704956
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62548067
138regulation of neurotransmitter secretion (GO:0046928)2.59924012
139positive regulation of dendritic spine morphogenesis (GO:0061003)2.59568663
140positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59496731
141neuron-neuron synaptic transmission (GO:0007270)2.59389950
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59192042
143positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58337319
144regulation of excitatory postsynaptic membrane potential (GO:0060079)2.57589203
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.57107135
146negative regulation of actin filament depolymerization (GO:0030835)2.57050170
147regulation of histone H3-K4 methylation (GO:0051569)2.56986777
148cellular response to epidermal growth factor stimulus (GO:0071364)2.56941722
149axonal fasciculation (GO:0007413)2.56460909
150DNA synthesis involved in DNA repair (GO:0000731)2.56180700
151erythrocyte maturation (GO:0043249)2.55696153
152regulation of histone methylation (GO:0031060)2.55449323
153histone H3-K9 demethylation (GO:0033169)2.55187225
154RNA localization (GO:0006403)2.54951574
155intraspecies interaction between organisms (GO:0051703)2.54472863
156social behavior (GO:0035176)2.54472863
157establishment of mitochondrion localization (GO:0051654)2.53993962
158protein localization to chromosome, centromeric region (GO:0071459)2.53618182
159regulation of histone H3-K27 methylation (GO:0061085)2.52785963
160DNA conformation change (GO:0071103)2.52408272
161auditory behavior (GO:0031223)2.52331033
162neuronal ion channel clustering (GO:0045161)2.52274850
163regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52161364
164convergent extension (GO:0060026)2.52007160
165regulation of neurotransmitter levels (GO:0001505)2.51839736
166porphyrin-containing compound metabolic process (GO:0006778)2.51043511
167negative regulation of RNA splicing (GO:0033119)2.50131671
168peptidyl-arginine N-methylation (GO:0035246)2.49849817
169peptidyl-arginine methylation (GO:0018216)2.49849817
170apoptotic process involved in morphogenesis (GO:0060561)2.48275890
171positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.47560082
172chromosome condensation (GO:0030261)2.47150671
173positive regulation of DNA-dependent DNA replication (GO:2000105)2.44902882
174histone H4-K5 acetylation (GO:0043981)2.43986538
175histone H4-K8 acetylation (GO:0043982)2.43986538
176nuclear envelope disassembly (GO:0051081)2.43597044
177membrane disassembly (GO:0030397)2.43597044
178mitotic nuclear envelope disassembly (GO:0007077)2.42816107
179V(D)J recombination (GO:0033151)2.42305514
180cell-substrate adherens junction assembly (GO:0007045)2.42240169
181focal adhesion assembly (GO:0048041)2.42240169
182nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.40138138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.21098834
2EZH2_22144423_ChIP-Seq_EOC_Human4.46816389
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.37139246
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.00572492
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.76905070
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70549753
7KDM2B_26808549_Chip-Seq_K562_Human2.52951575
8REST_21632747_ChIP-Seq_MESCs_Mouse2.41248014
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.34722511
10* GATA1_19941826_ChIP-Seq_K562_Human2.34597663
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.34252105
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.32402507
13ZNF263_19887448_ChIP-Seq_K562_Human2.24035707
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21870510
15VDR_21846776_ChIP-Seq_THP-1_Human2.20206269
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18992117
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.13366235
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12955836
19DROSHA_22980978_ChIP-Seq_HELA_Human2.10240049
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09682398
21* KDM2B_26808549_Chip-Seq_DND41_Human2.08753327
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98214029
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96554979
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96532318
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.92854893
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91311512
27ZFP281_27345836_Chip-Seq_ESCs_Mouse1.90989744
28* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.88235974
29XRN2_22483619_ChIP-Seq_HELA_Human1.87897381
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87443883
31* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.84704009
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84629887
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84467954
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.82485678
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81755720
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78398431
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.76879616
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74603801
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73903407
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71869885
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70106338
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69497884
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69396368
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68605536
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.68078377
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65263945
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63877996
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63877996
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.61886453
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61401016
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61389703
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.59781565
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59180039
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58440109
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57398875
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56573253
57RACK7_27058665_Chip-Seq_MCF-7_Human1.56099972
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55903694
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55675932
60* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55664193
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55431713
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.51174268
63* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51006458
64MYC_22102868_ChIP-Seq_BL_Human1.50864513
65* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48953837
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47184527
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46705398
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.46328028
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.45707249
70CREB1_26743006_Chip-Seq_LNCaP_Human1.43400411
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.42956376
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41640861
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41054221
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.39993764
75* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.37147239
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.36255852
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.33925793
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.33684017
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33589365
80* LXR_22292898_ChIP-Seq_THP-1_Human1.33534163
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32848628
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31522350
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31209935
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30382705
85CTCF_27219007_Chip-Seq_Bcells_Human1.28616690
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27953485
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27411320
88TCF7_22412390_ChIP-Seq_EML_Mouse1.27325470
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27224305
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26436984
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25707011
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25645240
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24461218
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21704113
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.21306923
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.20858169
97TET1_21490601_ChIP-Seq_MESCs_Mouse1.19783171
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18532487
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18316187
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18188632
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.17945612
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17600729
103CIITA_25753668_ChIP-Seq_RAJI_Human1.16923802
104NCOR1_26117541_ChIP-Seq_K562_Human1.16347970
105* OCT4_19829295_ChIP-Seq_ESCs_Human1.15967782
106KDM5A_27292631_Chip-Seq_BREAST_Human1.15289150
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15005197
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14863419
109* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14571626
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.14420659
111* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13723099
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12983116
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11053664
114AR_19668381_ChIP-Seq_PC3_Human1.11022410
115SMC4_20622854_ChIP-Seq_HELA_Human1.10192327
116POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08487611
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08211779
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07663111
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07311812
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07237822
121* GATA2_19941826_ChIP-Seq_K562_Human1.06908476
122TTF2_22483619_ChIP-Seq_HELA_Human1.06341717
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06317710
124* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05308615
125* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04320748
126P68_20966046_ChIP-Seq_HELA_Human1.03999397
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03934346
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99565182
129PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99545681
130* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98103363
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98046251
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97906201
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.97903631
134* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97769032
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97765978
136OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97660872
137KLF4_19829295_ChIP-Seq_ESCs_Human0.97341641
138ZNF274_21170338_ChIP-Seq_K562_Hela0.96831946
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96602188
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96250575
141* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96182071
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.96158260
143MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96101269
144SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94004547
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93994105
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93896649
147AR_21909140_ChIP-Seq_LNCAP_Human0.93511943
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93305592
149FOXP1_21924763_ChIP-Seq_HESCs_Human0.92981535
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92783901
151EED_16625203_ChIP-ChIP_MESCs_Mouse0.90724439
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.90099418
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89360610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.12534973
2MP0003656_abnormal_erythrocyte_physiolo3.47407366
3MP0003635_abnormal_synaptic_transmissio3.45062482
4MP0004270_analgesia3.39178480
5MP0003880_abnormal_central_pattern2.68387967
6MP0002063_abnormal_learning/memory/cond2.64797314
7MP0003693_abnormal_embryo_hatching2.59648428
8MP0010094_abnormal_chromosome_stability2.59324581
9MP0002734_abnormal_mechanical_nocicepti2.40610794
10MP0001968_abnormal_touch/_nociception2.39149023
11MP0009745_abnormal_behavioral_response2.38955746
12MP0002064_seizures2.30228797
13MP0004147_increased_porphyrin_level2.29774015
14MP0004957_abnormal_blastocyst_morpholog2.29669591
15MP0009046_muscle_twitch2.28345673
16MP0005423_abnormal_somatic_nervous2.23326130
17MP0003077_abnormal_cell_cycle2.19093211
18MP0004858_abnormal_nervous_system2.14989961
19MP0000566_synostosis2.06032969
20MP0002733_abnormal_thermal_nociception2.03548731
21MP0009780_abnormal_chondrocyte_physiolo2.01237131
22MP0000537_abnormal_urethra_morphology2.01232115
23MP0004811_abnormal_neuron_physiology1.98913897
24MP0003787_abnormal_imprinting1.97465520
25MP0008057_abnormal_DNA_replication1.96615199
26MP0002909_abnormal_adrenal_gland1.96434808
27MP0002572_abnormal_emotion/affect_behav1.90763036
28MP0002735_abnormal_chemical_nociception1.90221913
29MP0003283_abnormal_digestive_organ1.79948910
30MP0002736_abnormal_nociception_after1.78420465
31MP0001346_abnormal_lacrimal_gland1.77844042
32MP0002249_abnormal_larynx_morphology1.75634765
33MP0002272_abnormal_nervous_system1.74458681
34MP0003329_amyloid_beta_deposits1.70555645
35MP0001970_abnormal_pain_threshold1.70240301
36MP0003123_paternal_imprinting1.68650220
37MP0000955_abnormal_spinal_cord1.67783231
38MP0009278_abnormal_bone_marrow1.67659273
39MP0001440_abnormal_grooming_behavior1.62705409
40MP0001486_abnormal_startle_reflex1.61186369
41MP0002822_catalepsy1.60570804
42MP0001672_abnormal_embryogenesis/_devel1.59800953
43MP0005380_embryogenesis_phenotype1.59800953
44MP0008961_abnormal_basal_metabolism1.57785783
45MP0003122_maternal_imprinting1.55813875
46MP0005451_abnormal_body_composition1.54686665
47MP0008877_abnormal_DNA_methylation1.52331406
48MP0008569_lethality_at_weaning1.52278936
49MP0002184_abnormal_innervation1.52083926
50MP0000778_abnormal_nervous_system1.51381710
51MP0003984_embryonic_growth_retardation1.49558570
52MP0002653_abnormal_ependyma_morphology1.45514076
53MP0008932_abnormal_embryonic_tissue1.45083762
54MP0002085_abnormal_embryonic_tissue1.44491868
55MP0002067_abnormal_sensory_capabilities1.43169637
56MP0002080_prenatal_lethality1.42323279
57MP0002089_abnormal_postnatal_growth/wei1.42237583
58MP0002088_abnormal_embryonic_growth/wei1.42076574
59MP0004885_abnormal_endolymph1.39806712
60MP0001697_abnormal_embryo_size1.37342094
61MP0005076_abnormal_cell_differentiation1.36922522
62MP0005386_behavior/neurological_phenoty1.33742578
63MP0004924_abnormal_behavior1.33742578
64MP0004233_abnormal_muscle_weight1.28396826
65MP0002882_abnormal_neuron_morphology1.27914270
66MP0003879_abnormal_hair_cell1.25661641
67MP0010030_abnormal_orbit_morphology1.25615795
68MP0001501_abnormal_sleep_pattern1.24690486
69MP0002152_abnormal_brain_morphology1.24489236
70MP0005623_abnormal_meninges_morphology1.24263706
71MP0002066_abnormal_motor_capabilities/c1.23243345
72MP0002557_abnormal_social/conspecific_i1.22480263
73MP0000579_abnormal_nail_morphology1.22168078
74MP0003111_abnormal_nucleus_morphology1.20363427
75MP0003121_genomic_imprinting1.18945974
76MP0002697_abnormal_eye_size1.17977637
77MP0003942_abnormal_urinary_system1.17834670
78MP0000751_myopathy1.14327940
79MP0008058_abnormal_DNA_repair1.14284223
80MP0002396_abnormal_hematopoietic_system1.14269878
81MP0003705_abnormal_hypodermis_morpholog1.12967158
82MP0003890_abnormal_embryonic-extraembry1.12184195
83MP0003115_abnormal_respiratory_system1.11699414
84MP0000678_abnormal_parathyroid_gland1.09723383
85MP0000569_abnormal_digit_pigmentation1.09142987
86MP0003861_abnormal_nervous_system1.06517439
87MP0003938_abnormal_ear_development1.05489108
88MP0000313_abnormal_cell_death1.04037798
89MP0004145_abnormal_muscle_electrophysio1.03954738
90MP0005499_abnormal_olfactory_system1.03642584
91MP0005394_taste/olfaction_phenotype1.03642584
92MP0005409_darkened_coat_color1.03145486
93MP0005187_abnormal_penis_morphology1.03102914
94MP0002086_abnormal_extraembryonic_tissu1.02764242
95MP0003119_abnormal_digestive_system1.02687749
96MP0008770_decreased_survivor_rate1.01232275
97MP0008260_abnormal_autophagy0.99961818
98MP0003172_abnormal_lysosome_physiology0.99391481
99MP0010630_abnormal_cardiac_muscle0.99099029
100MP0003633_abnormal_nervous_system0.98828738
101MP0002081_perinatal_lethality0.95949455
102MP0000747_muscle_weakness0.95945793
103MP0008872_abnormal_physiological_respon0.93576108
104MP0003631_nervous_system_phenotype0.92581541
105MP0001849_ear_inflammation0.90595374
106MP0000013_abnormal_adipose_tissue0.90390323
107MP0010307_abnormal_tumor_latency0.89479019
108MP0010234_abnormal_vibrissa_follicle0.89186588
109MP0001299_abnormal_eye_distance/0.88020348
110MP0003315_abnormal_perineum_morphology0.87926217
111MP0004085_abnormal_heartbeat0.87826549
112MP0002877_abnormal_melanocyte_morpholog0.87722547
113MP0001348_abnormal_lacrimal_gland0.87187192
114MP0004808_abnormal_hematopoietic_stem0.87165325
115MP0005666_abnormal_adipose_tissue0.85857415
116MP0009379_abnormal_foot_pigmentation0.85577033
117MP0005645_abnormal_hypothalamus_physiol0.83518279
118MP0000003_abnormal_adipose_tissue0.82603379
119MP0001188_hyperpigmentation0.79214913
120MP0004742_abnormal_vestibular_system0.79169344
121MP0002229_neurodegeneration0.78976658
122MP0000428_abnormal_craniofacial_morphol0.77939528
123MP0005621_abnormal_cell_physiology0.77790142
124MP0002082_postnatal_lethality0.77343772
125MP0003632_abnormal_nervous_system0.77266759
126MP0002084_abnormal_developmental_patter0.76798251
127MP0005384_cellular_phenotype0.76517072
128MP0006276_abnormal_autonomic_nervous0.76010725
129MP0001730_embryonic_growth_arrest0.75452563
130MP0002116_abnormal_craniofacial_bone0.75440482
131MP0003634_abnormal_glial_cell0.74364009
132MP0006035_abnormal_mitochondrial_morpho0.73847556
133MP0004087_abnormal_muscle_fiber0.73308924
134MP0000534_abnormal_ureter_morphology0.73180941
135MP0004185_abnormal_adipocyte_glucose0.72209383
136MP0002114_abnormal_axial_skeleton0.71245634
137MP0009672_abnormal_birth_weight0.71050875
138MP0008007_abnormal_cellular_replicative0.70684636
139MP0002234_abnormal_pharynx_morphology0.70431398
140MP0001529_abnormal_vocalization0.69945153
141MP0010769_abnormal_survival0.67596436
142MP0001984_abnormal_olfaction0.67364925
143MP0002069_abnormal_eating/drinking_beha0.67294238
144MP0002269_muscular_atrophy0.66665996
145MP0009703_decreased_birth_body0.66025341
146MP0002837_dystrophic_cardiac_calcinosis0.65368025
147MP0010768_mortality/aging0.64415802
148MP0004142_abnormal_muscle_tone0.62558436
149MP0003698_abnormal_male_reproductive0.60822149
150MP0004130_abnormal_muscle_cell0.59999936
151MP0000350_abnormal_cell_proliferation0.59879520
152MP0004197_abnormal_fetal_growth/weight/0.59850151
153MP0010770_preweaning_lethality0.59539098

Predicted human phenotypes

RankGene SetZ-score
1Insomnia (HP:0100785)4.68053756
2Myokymia (HP:0002411)4.58535274
3Poikilocytosis (HP:0004447)4.55733723
4Visual hallucinations (HP:0002367)4.10537685
5Focal seizures (HP:0007359)3.93210658
6Focal motor seizures (HP:0011153)3.82617376
7Hypochromic microcytic anemia (HP:0004840)3.74165446
8Abnormality of the lower motor neuron (HP:0002366)3.61529013
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.40584538
10Reticulocytosis (HP:0001923)3.37395698
11Depression (HP:0000716)3.14119116
12Ankle clonus (HP:0011448)3.03303937
13Supranuclear gaze palsy (HP:0000605)3.00795478
14Action tremor (HP:0002345)2.84121250
15Papilledema (HP:0001085)2.81059394
16Epileptic encephalopathy (HP:0200134)2.79159671
17Urinary bladder sphincter dysfunction (HP:0002839)2.76377954
18Termporal pattern (HP:0011008)2.76082746
19Insidious onset (HP:0003587)2.76082746
20Increased nuchal translucency (HP:0010880)2.74529183
21Urethral obstruction (HP:0000796)2.73578162
22Generalized tonic-clonic seizures (HP:0002069)2.73546278
23Hyperacusis (HP:0010780)2.68284243
24Cholelithiasis (HP:0001081)2.67880946
25Impaired vibration sensation in the lower limbs (HP:0002166)2.62715848
26Acanthocytosis (HP:0001927)2.62598694
27Urinary urgency (HP:0000012)2.61526547
28Postural instability (HP:0002172)2.59254761
29Atonic seizures (HP:0010819)2.58073584
30High anterior hairline (HP:0009890)2.56085185
31Diaphragmatic weakness (HP:0009113)2.53368531
32Pointed chin (HP:0000307)2.51015580
33Progressive cerebellar ataxia (HP:0002073)2.50839397
34Abnormality of reticulocytes (HP:0004312)2.49488877
35Turricephaly (HP:0000262)2.48660775
36Impaired social interactions (HP:0000735)2.47739666
37Abnormal social behavior (HP:0012433)2.47739666
38Abnormality of cochlea (HP:0000375)2.46959437
39Lower limb amyotrophy (HP:0007210)2.44916331
40Trigonocephaly (HP:0000243)2.43870467
41Absence seizures (HP:0002121)2.43458258
42Broad distal phalanx of finger (HP:0009836)2.42667181
43Abnormality of the fingertips (HP:0001211)2.42582538
44Poor eye contact (HP:0000817)2.40064225
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38454079
46Febrile seizures (HP:0002373)2.36217523
47Dysmetric saccades (HP:0000641)2.36072400
48Truncal ataxia (HP:0002078)2.36004551
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34383931
50Hemiparesis (HP:0001269)2.30726537
51Abnormal gallbladder morphology (HP:0012437)2.30282057
52Impaired smooth pursuit (HP:0007772)2.29746459
53Resting tremor (HP:0002322)2.29449119
54Bronchomalacia (HP:0002780)2.27858617
55Long palpebral fissure (HP:0000637)2.27102712
56Macroorchidism (HP:0000053)2.26883260
57Amyotrophic lateral sclerosis (HP:0007354)2.24969131
58Ulnar bowing (HP:0003031)2.24406124
59Dialeptic seizures (HP:0011146)2.24178053
60Amblyopia (HP:0000646)2.22517947
61Progressive muscle weakness (HP:0003323)2.21038654
62Astrocytoma (HP:0009592)2.20923584
63Abnormality of the astrocytes (HP:0100707)2.20923584
64Dysdiadochokinesis (HP:0002075)2.20217969
65Cerebral inclusion bodies (HP:0100314)2.19917563
66Truncus arteriosus (HP:0001660)2.19120870
67Ventricular fibrillation (HP:0001663)2.18795077
68Genetic anticipation (HP:0003743)2.14515434
69Obsessive-compulsive behavior (HP:0000722)2.14075401
70Spastic gait (HP:0002064)2.13380628
71Morphological abnormality of the inner ear (HP:0011390)2.13321236
72Annular pancreas (HP:0001734)2.13263810
73Birth length less than 3rd percentile (HP:0003561)2.11556666
74Mutism (HP:0002300)2.11336160
75Disproportionate tall stature (HP:0001519)2.11179853
76Abnormality of the corticospinal tract (HP:0002492)2.11151769
77Shallow orbits (HP:0000586)2.10948015
78Heterotopia (HP:0002282)2.10016542
79Abnormality of ocular smooth pursuit (HP:0000617)2.09563147
80Reticulocytopenia (HP:0001896)2.08045921
81Hemiplegia (HP:0002301)2.07974235
82Anxiety (HP:0000739)2.05304257
83Hypercortisolism (HP:0001578)2.05042936
84Global brain atrophy (HP:0002283)2.04997706
85Bradykinesia (HP:0002067)2.04832334
86Bowel incontinence (HP:0002607)2.04665826
87Bundle branch block (HP:0011710)2.04549073
88Chromsome breakage (HP:0040012)2.04397900
89Elfin facies (HP:0004428)2.02223098
90Partial duplication of thumb phalanx (HP:0009944)2.01640661
91Upper limb amyotrophy (HP:0009129)2.01612792
92Distal upper limb amyotrophy (HP:0007149)2.01612792
93Abnormality of the salivary glands (HP:0010286)2.01032990
94Long eyelashes (HP:0000527)2.00941671
95Overriding aorta (HP:0002623)2.00933679
96Progressive external ophthalmoplegia (HP:0000590)1.99632874
97Peripheral hypomyelination (HP:0007182)1.97705912
98Attention deficit hyperactivity disorder (HP:0007018)1.96918406
99Duplication of thumb phalanx (HP:0009942)1.96159950
100Dysmetria (HP:0001310)1.95495743
101Lower limb muscle weakness (HP:0007340)1.95458539
102Sacral dimple (HP:0000960)1.94340995
103Ependymoma (HP:0002888)1.94039864
104Megalencephaly (HP:0001355)1.91605355
105Obstructive sleep apnea (HP:0002870)1.91413467
106Neoplasm of the heart (HP:0100544)1.91380176
107Abnormal large intestine physiology (HP:0012700)1.90842375
108Delusions (HP:0000746)1.90479373
109Renal duplication (HP:0000075)1.89261822
110Partial duplication of the phalanx of hand (HP:0009999)1.87867389
111Abnormal number of incisors (HP:0011064)1.87678373
112Abnormality of binocular vision (HP:0011514)1.86384067
113Diplopia (HP:0000651)1.86384067
114Dysphonia (HP:0001618)1.85822145
115Hand muscle atrophy (HP:0009130)1.85704230
116Achilles tendon contracture (HP:0001771)1.85085385
117Renovascular hypertension (HP:0100817)1.84833616
118Ankyloglossia (HP:0010296)1.84133578
11911 pairs of ribs (HP:0000878)1.84085783
120Abnormality of homocysteine metabolism (HP:0010919)1.83771500
121Homocystinuria (HP:0002156)1.83771500
122Thin ribs (HP:0000883)1.80888566
123Rapidly progressive (HP:0003678)1.80430322
124Proximal placement of thumb (HP:0009623)1.80392536
125Clonus (HP:0002169)1.80255275
126Patellar dislocation (HP:0002999)1.79509519
127Generalized hypotonia (HP:0001290)1.79353872
128Broad thumb (HP:0011304)1.78604502
129Abnormality of the calcaneus (HP:0008364)1.77765196
130Abnormality of the labia minora (HP:0012880)1.77580639
131Asymmetry of the thorax (HP:0001555)1.75849496
132Gaze-evoked nystagmus (HP:0000640)1.75041588
133Deviation of the thumb (HP:0009603)1.74552861
134Intention tremor (HP:0002080)1.74502472
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74471338
136Broad face (HP:0000283)1.74191078
137Abnormality of cells of the erythroid lineage (HP:0012130)1.74164035
138Status epilepticus (HP:0002133)1.74160695
139Abnormality of the aortic arch (HP:0012303)1.74001157
140Cafe-au-lait spot (HP:0000957)1.73471842
141Hypsarrhythmia (HP:0002521)1.73210245
142EEG with generalized epileptiform discharges (HP:0011198)1.72526469
143Breast hypoplasia (HP:0003187)1.72406467
144Shoulder girdle muscle weakness (HP:0003547)1.71255974
145Hyperthyroidism (HP:0000836)1.70675079
146Deep palmar crease (HP:0006191)1.68857123
147Apathy (HP:0000741)1.68637503
148Spina bifida occulta (HP:0003298)1.68510230
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.68186096
150Germ cell neoplasia (HP:0100728)1.68007585
151Enlarged penis (HP:0000040)1.67979611
152Difficulty running (HP:0009046)1.67760276
153Bowel diverticulosis (HP:0005222)1.67571083
154Abnormal gallbladder physiology (HP:0012438)1.67318048
155Cholecystitis (HP:0001082)1.67318048
156Atresia of the external auditory canal (HP:0000413)1.67018755
157Supernumerary ribs (HP:0005815)1.66463061
158Abnormality of chromosome segregation (HP:0002916)1.65987613
159Self-mutilation (HP:0000742)1.64788713
160Precocious puberty (HP:0000826)1.64447961
161Myopathic facies (HP:0002058)1.63751168
162Abnormality of the gallbladder (HP:0005264)1.63513437
163Distal lower limb amyotrophy (HP:0008944)1.59985416
164Abnormality of the phalanges of the hallux (HP:0010057)1.56870748
165Septate vagina (HP:0001153)1.56777179
166Impulsivity (HP:0100710)1.55988100
167Preauricular skin tag (HP:0000384)1.55924829
168Abnormal number of erythroid precursors (HP:0012131)1.55882663
169Pseudobulbar signs (HP:0002200)1.55593928
170Overlapping toe (HP:0001845)1.55527677
171Arnold-Chiari malformation (HP:0002308)1.55156640
172Broad palm (HP:0001169)1.54911599
173Ectopic kidney (HP:0000086)1.53690201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.00946666
2SMG13.79609043
3NTRK33.24183661
4MARK13.02741778
5PRKD32.76250420
6PRPF4B2.51940466
7PAK62.41379466
8CDK122.34471072
9KSR22.34447064
10EPHA42.31378478
11MAP3K42.31363981
12MINK12.28122200
13LATS22.18051918
14DAPK22.16379057
15TRIB32.15128744
16TAOK12.02870129
17NTRK11.95678895
18FGFR41.78537584
19SIK11.77762835
20SCYL21.77019401
21ALK1.75239304
22EEF2K1.74850212
23NTRK21.64745675
24CAMKK11.63722627
25TYRO31.56626036
26NEK11.46340260
27ICK1.45755719
28SIK21.44408475
29STK381.41876858
30PKN21.33053284
31BRSK11.32433745
32KSR11.32037991
33GRK51.27066514
34RET1.26722523
35UHMK11.25041718
36CDK51.24329369
37PHKG11.24293537
38PHKG21.24293537
39MAP2K41.23856771
40PNCK1.22573365
41MAP3K21.15019272
42CDK41.08511304
43CDC71.07673733
44CDC42BPA1.05011716
45TTK1.04751372
46FGFR21.03074341
47PASK1.01310200
48STK111.00717264
49PDGFRA0.95141837
50DAPK10.94417374
51CDK150.93950976
52BUB10.93753901
53RIPK10.93490491
54MAP2K70.90283076
55BMX0.89992326
56MAP3K100.89374231
57PRKCH0.88800054
58CHEK20.88493161
59CDK180.88128725
60CDK140.88080189
61LMTK20.87526488
62CAMK1G0.87283250
63EIF2AK10.87052827
64CDK70.83577044
65CDK11A0.83454368
66IRAK30.81911574
67STK40.78909170
68WNK10.78562079
69MARK20.77218031
70SGK30.76742301
71MAP3K130.76586383
72TSSK60.76580357
73ATR0.75740932
74TAOK20.75350150
75NME10.74997574
76MAPK130.74751394
77BRAF0.74678361
78TLK10.72632486
79NEK20.70008613
80PAK30.69891538
81MTOR0.68344891
82PRKAA10.68271420
83NME20.68034171
84MAP2K30.67858756
85VRK20.67105592
86AKT20.66950785
87PRKCG0.66334407
88SGK10.64783185
89TTN0.63500808
90RPS6KB20.63169222
91RPS6KA30.62788721
92MAPK110.61515354
93MAP3K80.60646061
94RIPK40.60445036
95PLK20.60017281
96MAP2K10.58909567
97MAPK100.57380399
98SGK2230.57124772
99SGK4940.57124772
100PDK10.56490480
101RPS6KA20.55673857
102MAP3K10.53734802
103PTK60.53256431
104TAF10.52003091
105CSNK1E0.51512560
106DYRK1A0.51375177
107CSNK1D0.50871739
108MAP3K110.50343506
109DDR20.48515602
110DAPK30.48430958
111PTK2B0.48000023
112ERBB20.46976618
113PDPK10.45901541
114CAMK10.45367451
115ARAF0.45215819
116MAPK80.45039639
117CSNK1G20.44949423
118CAMK1D0.44914000
119GSK3B0.44474999
120RPS6KA10.43456601
121DMPK0.43231209
122MAPK140.43221266
123* CDK20.42247325
124CHEK10.41586973
125MAP3K70.41535016
126AKT10.41495852
127PLK10.40830135
128PLK30.40560575
129CAMK40.40064199
130RAF10.39059539
131AURKA0.38951946
132SGK20.37671755
133BRD40.37470447
134PINK10.36662102
135PRKDC0.36568651
136PTK20.36239744
137CDK10.35875971
138HIPK20.34531898

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.83378808
2Synaptic vesicle cycle_Homo sapiens_hsa047212.76467567
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.50369149
4Olfactory transduction_Homo sapiens_hsa047402.32916778
5Long-term potentiation_Homo sapiens_hsa047202.28114238
6Nicotine addiction_Homo sapiens_hsa050332.16582224
7GABAergic synapse_Homo sapiens_hsa047272.00914153
8Circadian entrainment_Homo sapiens_hsa047131.99055633
9Amphetamine addiction_Homo sapiens_hsa050311.87255695
10Spliceosome_Homo sapiens_hsa030401.85822089
11Insulin secretion_Homo sapiens_hsa049111.83736817
12Dopaminergic synapse_Homo sapiens_hsa047281.80914396
13Glutamatergic synapse_Homo sapiens_hsa047241.76687380
14Cell cycle_Homo sapiens_hsa041101.75972066
15Morphine addiction_Homo sapiens_hsa050321.74141980
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70775978
17Dorso-ventral axis formation_Homo sapiens_hsa043201.68429236
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67739017
19Alcoholism_Homo sapiens_hsa050341.67697775
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67216477
21Mismatch repair_Homo sapiens_hsa034301.66660660
22Glioma_Homo sapiens_hsa052141.65950862
23Salivary secretion_Homo sapiens_hsa049701.65567285
24Base excision repair_Homo sapiens_hsa034101.60260112
25Cholinergic synapse_Homo sapiens_hsa047251.58279997
26Notch signaling pathway_Homo sapiens_hsa043301.58025728
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56081930
28Oocyte meiosis_Homo sapiens_hsa041141.54173698
29Gastric acid secretion_Homo sapiens_hsa049711.54124101
30Type II diabetes mellitus_Homo sapiens_hsa049301.53993407
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53833444
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53198046
33Gap junction_Homo sapiens_hsa045401.46296582
34Oxytocin signaling pathway_Homo sapiens_hsa049211.45278385
35Estrogen signaling pathway_Homo sapiens_hsa049151.44239135
36Lysine degradation_Homo sapiens_hsa003101.42685777
37GnRH signaling pathway_Homo sapiens_hsa049121.38079530
38mTOR signaling pathway_Homo sapiens_hsa041501.37391449
39Cocaine addiction_Homo sapiens_hsa050301.32433791
40Biosynthesis of amino acids_Homo sapiens_hsa012301.32242652
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28998854
42Long-term depression_Homo sapiens_hsa047301.25943985
43Renin secretion_Homo sapiens_hsa049241.25461689
44RNA transport_Homo sapiens_hsa030131.24212897
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23076211
46Acute myeloid leukemia_Homo sapiens_hsa052211.18362860
47MicroRNAs in cancer_Homo sapiens_hsa052061.17813586
48ErbB signaling pathway_Homo sapiens_hsa040121.16843034
49Non-small cell lung cancer_Homo sapiens_hsa052231.15514110
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14986037
51Taste transduction_Homo sapiens_hsa047421.12752258
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10576755
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10564820
54Ribosome_Homo sapiens_hsa030101.09871492
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08941334
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.08492102
57Endometrial cancer_Homo sapiens_hsa052131.08212438
58Systemic lupus erythematosus_Homo sapiens_hsa053221.08163532
59One carbon pool by folate_Homo sapiens_hsa006701.08086703
60Nitrogen metabolism_Homo sapiens_hsa009101.06334296
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04877574
62Fructose and mannose metabolism_Homo sapiens_hsa000511.04839088
63cAMP signaling pathway_Homo sapiens_hsa040241.04638304
64Basal cell carcinoma_Homo sapiens_hsa052171.04566129
65Vitamin B6 metabolism_Homo sapiens_hsa007501.04557534
66Melanogenesis_Homo sapiens_hsa049161.03548956
67Calcium signaling pathway_Homo sapiens_hsa040201.02822080
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02180279
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00559240
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99854333
71Prostate cancer_Homo sapiens_hsa052150.98106782
72Axon guidance_Homo sapiens_hsa043600.97016935
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96318351
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.95819315
75VEGF signaling pathway_Homo sapiens_hsa043700.93141793
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91783502
77Renal cell carcinoma_Homo sapiens_hsa052110.91225648
78Non-homologous end-joining_Homo sapiens_hsa034500.89855262
79Insulin signaling pathway_Homo sapiens_hsa049100.89818913
80Serotonergic synapse_Homo sapiens_hsa047260.88898502
81Collecting duct acid secretion_Homo sapiens_hsa049660.88569548
82Glucagon signaling pathway_Homo sapiens_hsa049220.87555384
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.86266660
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85432945
85MAPK signaling pathway_Homo sapiens_hsa040100.85268515
86Adherens junction_Homo sapiens_hsa045200.84109515
87Nucleotide excision repair_Homo sapiens_hsa034200.83988823
88Chronic myeloid leukemia_Homo sapiens_hsa052200.83681251
89Pentose phosphate pathway_Homo sapiens_hsa000300.83543648
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83411043
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82926064
92HIF-1 signaling pathway_Homo sapiens_hsa040660.82776638
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81218372
94Choline metabolism in cancer_Homo sapiens_hsa052310.80977691
95Prion diseases_Homo sapiens_hsa050200.80348683
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.77076071
97Endocytosis_Homo sapiens_hsa041440.76995872
98Dilated cardiomyopathy_Homo sapiens_hsa054140.75570821
99Bladder cancer_Homo sapiens_hsa052190.75071572
100AMPK signaling pathway_Homo sapiens_hsa041520.72954253
101B cell receptor signaling pathway_Homo sapiens_hsa046620.71874327
102Homologous recombination_Homo sapiens_hsa034400.71731710
103mRNA surveillance pathway_Homo sapiens_hsa030150.70570024
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69094098
105Thyroid hormone synthesis_Homo sapiens_hsa049180.68891671
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67076369
107Colorectal cancer_Homo sapiens_hsa052100.67018028
108Pancreatic secretion_Homo sapiens_hsa049720.64049530
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63032595
110Inositol phosphate metabolism_Homo sapiens_hsa005620.62970106
111* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61038176
112Wnt signaling pathway_Homo sapiens_hsa043100.60742937
113Hippo signaling pathway_Homo sapiens_hsa043900.60260417
114Prolactin signaling pathway_Homo sapiens_hsa049170.59703110
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59305209
116Tight junction_Homo sapiens_hsa045300.58656910
117Small cell lung cancer_Homo sapiens_hsa052220.57940197
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.57889924
119Rap1 signaling pathway_Homo sapiens_hsa040150.56829282
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56163057
121Viral carcinogenesis_Homo sapiens_hsa052030.54753811
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53408803
123Thyroid cancer_Homo sapiens_hsa052160.53375658
124HTLV-I infection_Homo sapiens_hsa051660.52479022
125Carbon metabolism_Homo sapiens_hsa012000.52221470
126Hedgehog signaling pathway_Homo sapiens_hsa043400.52146848
127Melanoma_Homo sapiens_hsa052180.51291371
128Ras signaling pathway_Homo sapiens_hsa040140.49989966
129Pancreatic cancer_Homo sapiens_hsa052120.49775076
130FoxO signaling pathway_Homo sapiens_hsa040680.49112387
131Insulin resistance_Homo sapiens_hsa049310.47869821
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47379088
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.46869123
134Cardiac muscle contraction_Homo sapiens_hsa042600.45881049
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45715367
136Bile secretion_Homo sapiens_hsa049760.45695153

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