ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular ketone body metabolic process (GO:0046950)	4.82957812
2	ketone body metabolic process (GO:1902224)	4.22565729
3	insulin secretion (GO:0030073)	3.76032754
4	epithelial cilium movement (GO:0003351)	3.76005558
5	acrosome reaction (GO:0007340)	3.66285936
6	behavioral response to nicotine (GO:0035095)	3.61484367
7	peptidyl-histidine modification (GO:0018202)	3.60201459
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.53838841
9	sperm motility (GO:0030317)	3.45799950
10	protein complex biogenesis (GO:0070271)	3.44824802
11	synapsis (GO:0007129)	3.37695469
12	intraciliary transport (GO:0042073)	3.30817129
13	coenzyme catabolic process (GO:0009109)	3.29529402
14	presynaptic membrane assembly (GO:0097105)	3.25652255
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16052082
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16052082
17	NADH dehydrogenase complex assembly (GO:0010257)	3.16052082
18	inositol phosphate catabolic process (GO:0071545)	3.13362466
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11377492
20	regulation of cilium movement (GO:0003352)	3.11220177
21	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.09502473
22	platelet dense granule organization (GO:0060155)	3.09208284
23	pyrimidine nucleobase catabolic process (GO:0006208)	3.04251251
24	nonmotile primary cilium assembly (GO:0035058)	2.99833163
25	retinal cone cell development (GO:0046549)	2.98092912
26	presynaptic membrane organization (GO:0097090)	2.91282138
27	potassium ion export (GO:0071435)	2.91152176
28	peroxisome fission (GO:0016559)	2.90719443
29	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.88263472
30	gamma-aminobutyric acid transport (GO:0015812)	2.85894532
31	replication fork processing (GO:0031297)	2.84964440
32	respiratory chain complex IV assembly (GO:0008535)	2.83887661
33	cilium assembly (GO:0042384)	2.82068926
34	cilium organization (GO:0044782)	2.80941269
35	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.80228853
36	inositol phosphate dephosphorylation (GO:0046855)	2.80228853
37	protein polyglutamylation (GO:0018095)	2.79787984
38	S-adenosylmethionine metabolic process (GO:0046500)	2.74197128
39	cilium movement (GO:0003341)	2.72664813
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.72643690
41	peptide hormone secretion (GO:0030072)	2.72441758
42	tachykinin receptor signaling pathway (GO:0007217)	2.72353460
43	axonemal dynein complex assembly (GO:0070286)	2.70099286
44	mannosylation (GO:0097502)	2.69390372
45	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.69091334
46	multicellular organism reproduction (GO:0032504)	2.69069911
47	protein localization to cilium (GO:0061512)	2.68349633
48	magnesium ion transport (GO:0015693)	2.65932313
49	signal peptide processing (GO:0006465)	2.65616722
50	peptide secretion (GO:0002790)	2.65587093
51	cilium morphogenesis (GO:0060271)	2.65041221
52	spermatid development (GO:0007286)	2.62484965
53	dopamine transport (GO:0015872)	2.61925930
54	resolution of meiotic recombination intermediates (GO:0000712)	2.60932408
55	cytochrome complex assembly (GO:0017004)	2.58658787
56	retinal ganglion cell axon guidance (GO:0031290)	2.57635253
57	neuronal action potential propagation (GO:0019227)	2.57514540
58	motile cilium assembly (GO:0044458)	2.56065359
59	water-soluble vitamin biosynthetic process (GO:0042364)	2.54818207
60	activation of protein kinase B activity (GO:0032148)	2.54727508
61	response to pheromone (GO:0019236)	2.54006297
62	polyol catabolic process (GO:0046174)	2.51803101
63	nucleobase catabolic process (GO:0046113)	2.50737807
64	C-terminal protein lipidation (GO:0006501)	2.50464268
65	DNA integration (GO:0015074)	2.49990605
66	acrosome assembly (GO:0001675)	2.49675800
67	glycosphingolipid biosynthetic process (GO:0006688)	2.47675588
68	lactate metabolic process (GO:0006089)	2.46372341
69	organic cation transport (GO:0015695)	2.46316424
70	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.46129325
71	positive regulation of mitochondrial fission (GO:0090141)	2.45451750
72	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.45090872
73	single fertilization (GO:0007338)	2.45042565
74	neuronal action potential (GO:0019228)	2.44876557
75	neuron cell-cell adhesion (GO:0007158)	2.44778009
76	indole-containing compound catabolic process (GO:0042436)	2.43864092
77	indolalkylamine catabolic process (GO:0046218)	2.43864092
78	tryptophan catabolic process (GO:0006569)	2.43864092
79	negative regulation of membrane potential (GO:0045837)	2.42574550
80	positive regulation of action potential (GO:0045760)	2.39542861
81	nitric oxide mediated signal transduction (GO:0007263)	2.39519542
82	DNA double-strand break processing (GO:0000729)	2.38150819
83	neurotransmitter-gated ion channel clustering (GO:0072578)	2.37480782
84	endocrine pancreas development (GO:0031018)	2.36785645
85	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.36630500
86	adaptation of signaling pathway (GO:0023058)	2.36463207
87	regulation of glucokinase activity (GO:0033131)	2.35313099
88	regulation of hexokinase activity (GO:1903299)	2.35313099
89	calcium ion-dependent exocytosis (GO:0017156)	2.34829554
90	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.34689210
91	seminiferous tubule development (GO:0072520)	2.33503319
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.32801106
93	termination of RNA polymerase III transcription (GO:0006386)	2.32801106
94	RNA destabilization (GO:0050779)	2.32733280
95	positive regulation of amine transport (GO:0051954)	2.32502758
96	synapse assembly (GO:0007416)	2.31937110
97	regulation of feeding behavior (GO:0060259)	2.31820195
98	protein-cofactor linkage (GO:0018065)	2.31816850
99	dendritic spine morphogenesis (GO:0060997)	2.30480727
100	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.29890375

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.92905180
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.84139028
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.57752890
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.83151678
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.80820533
6	FUS_26573619_Chip-Seq_HEK293_Human	2.69617828
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.66533692
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60022390
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58643537
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46838887
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.46627160
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.41220905
13	VDR_22108803_ChIP-Seq_LS180_Human	2.40250460
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.33092929
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.15800670
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.15095361
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14196791
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.04864616
19	P300_19829295_ChIP-Seq_ESCs_Human	2.01032989
20	EZH2_22144423_ChIP-Seq_EOC_Human	2.01025721
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.93929678
22	EWS_26573619_Chip-Seq_HEK293_Human	1.90017787
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.67972739
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67081373
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66163476
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.64182301
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.62213194
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.55996306
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52397797
30	AR_25329375_ChIP-Seq_VCAP_Human	1.51995120
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.51000824
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49862216
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48718765
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.48718765
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45875482
36	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.43455455
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42114202
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41662325
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41285445
40	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.41054302
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40663673
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40622038
43	STAT3_23295773_ChIP-Seq_U87_Human	1.37791200
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36245008
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35423037
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.35204835
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34397456
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34397456
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34233089
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31763433
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30568166
52	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.29775872
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26175946
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25437254
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.25094133
56	TCF4_23295773_ChIP-Seq_U87_Human	1.19700118
57	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.19091471
58	NCOR_22424771_ChIP-Seq_293T_Human	1.17411646
59	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17074069
60	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.15374686
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12312386
62	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.10758553
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.09639538
64	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.09211005
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08091854
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08091854
67	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07026338
68	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06092724
69	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05638333
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.05584299
71	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05574136
72	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05238796
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04760336
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.04084700
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01798273
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01260036
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00562869
78	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99172509
79	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99141117
80	TBL1_22424771_ChIP-Seq_293T_Human	0.97876013
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97027210
82	NFYB_21822215_ChIP-Seq_K562_Human	0.96288446
83	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.95789851
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94661722
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93310594
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93310594
87	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93190938
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93175972
89	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.92957804
90	PHF8_20622853_ChIP-Seq_HELA_Human	0.91593072
91	JUN_21703547_ChIP-Seq_K562_Human	0.90806597
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90741057
93	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.90274627
94	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.90011284
95	VDR_23849224_ChIP-Seq_CD4+_Human	0.89910354
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89501064
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89488162
98	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.88959683
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.87518784
100	TP53_18474530_ChIP-ChIP_U2OS_Human	0.86608559

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	2.91298829
2	MP0002837_dystrophic_cardiac_calcinosis	2.72733753
3	MP0001984_abnormal_olfaction	2.62602707
4	MP0003880_abnormal_central_pattern	2.52118075
5	MP0006072_abnormal_retinal_apoptosis	2.49163934
6	MP0005379_endocrine/exocrine_gland_phen	2.37400213
7	MP0004147_increased_porphyrin_level	2.31769617
8	MP0001529_abnormal_vocalization	2.23473083
9	MP0005646_abnormal_pituitary_gland	2.19097907
10	MP0006276_abnormal_autonomic_nervous	2.14689746
11	MP0005410_abnormal_fertilization	2.08723837
12	MP0002638_abnormal_pupillary_reflex	2.04374982
13	MP0004270_analgesia	2.01462944
14	MP0001968_abnormal_touch/_nociception	2.01103054
15	MP0000013_abnormal_adipose_tissue	1.95460889
16	MP0000372_irregular_coat_pigmentation	1.94915486
17	MP0005645_abnormal_hypothalamus_physiol	1.92724370
18	MP0009780_abnormal_chondrocyte_physiolo	1.88608240
19	MP0008995_early_reproductive_senescence	1.83548765
20	MP0000516_abnormal_urinary_system	1.78715190
21	MP0005367_renal/urinary_system_phenotyp	1.78715190
22	MP0005551_abnormal_eye_electrophysiolog	1.78337265
23	MP0005253_abnormal_eye_physiology	1.75912389
24	MP0010386_abnormal_urinary_bladder	1.74037771
25	MP0009745_abnormal_behavioral_response	1.73945327
26	MP0001905_abnormal_dopamine_level	1.67043722
27	MP0002102_abnormal_ear_morphology	1.65860119
28	MP0009046_muscle_twitch	1.64396855
29	MP0004133_heterotaxia	1.52401287
30	MP0002822_catalepsy	1.51148195
31	MP0002234_abnormal_pharynx_morphology	1.50040261
32	MP0002160_abnormal_reproductive_system	1.48209408
33	MP0005187_abnormal_penis_morphology	1.47806781
34	MP0002272_abnormal_nervous_system	1.47224482
35	MP0003122_maternal_imprinting	1.46283868
36	MP0008877_abnormal_DNA_methylation	1.44720623
37	MP0002876_abnormal_thyroid_physiology	1.43046192
38	MP0002734_abnormal_mechanical_nocicepti	1.41180355
39	MP0003718_maternal_effect	1.40138663
40	MP0002909_abnormal_adrenal_gland	1.37208866
41	MP0008058_abnormal_DNA_repair	1.36698429
42	MP0002735_abnormal_chemical_nociception	1.34217459
43	MP0006292_abnormal_olfactory_placode	1.32424272
44	MP0001970_abnormal_pain_threshold	1.32422595
45	MP0002557_abnormal_social/conspecific_i	1.28552042
46	MP0001764_abnormal_homeostasis	1.27783840
47	MP0003787_abnormal_imprinting	1.27609225
48	MP0000631_abnormal_neuroendocrine_gland	1.27337471
49	MP0004142_abnormal_muscle_tone	1.27156780
50	MP0002736_abnormal_nociception_after	1.27072334
51	MP0002139_abnormal_hepatobiliary_system	1.25135087
52	MP0002751_abnormal_autonomic_nervous	1.23991694
53	MP0002572_abnormal_emotion/affect_behav	1.22165844
54	MP0003698_abnormal_male_reproductive	1.19378977
55	MP0001502_abnormal_circadian_rhythm	1.18335812
56	MP0003635_abnormal_synaptic_transmissio	1.17381544
57	MP0002064_seizures	1.17380357
58	MP0008775_abnormal_heart_ventricle	1.16181066
59	MP0003195_calcinosis	1.13560963
60	MP0004885_abnormal_endolymph	1.13313293
61	MP0001929_abnormal_gametogenesis	1.11858991
62	MP0002733_abnormal_thermal_nociception	1.11491575
63	MP0001486_abnormal_startle_reflex	1.10969079
64	MP0005394_taste/olfaction_phenotype	1.10366727
65	MP0005499_abnormal_olfactory_system	1.10366727
66	MP0005248_abnormal_Harderian_gland	1.09997724
67	MP0002063_abnormal_learning/memory/cond	1.09390738
68	MP0001944_abnormal_pancreas_morphology	1.07553117
69	MP0001756_abnormal_urination	1.06589700
70	MP0003121_genomic_imprinting	1.05996004
71	MP0009697_abnormal_copulation	1.05968289
72	MP0004043_abnormal_pH_regulation	1.05921509
73	MP0003315_abnormal_perineum_morphology	1.04986616
74	MP0003890_abnormal_embryonic-extraembry	1.04968792
75	MP0001270_distended_abdomen	1.04592383
76	MP0001501_abnormal_sleep_pattern	1.04484040
77	MP0002938_white_spotting	1.03351142
78	MP0001188_hyperpigmentation	1.03177459
79	MP0005332_abnormal_amino_acid	1.01016399
80	MP0000538_abnormal_urinary_bladder	1.00418275
81	MP0006036_abnormal_mitochondrial_physio	0.96997966
82	MP0002067_abnormal_sensory_capabilities	0.96598278
83	MP0005389_reproductive_system_phenotype	0.96537624
84	MP0004924_abnormal_behavior	0.93753631
85	MP0005386_behavior/neurological_phenoty	0.93753631
86	MP0008789_abnormal_olfactory_epithelium	0.92986985
87	MP0005220_abnormal_exocrine_pancreas	0.92473602
88	MP0004215_abnormal_myocardial_fiber	0.89194176
89	MP0003786_premature_aging	0.88609735
90	MP0002693_abnormal_pancreas_physiology	0.88504368
91	MP0002233_abnormal_nose_morphology	0.88306123
92	MP0004859_abnormal_synaptic_plasticity	0.87675659
93	MP0000049_abnormal_middle_ear	0.86369169
94	MP0005084_abnormal_gallbladder_morpholo	0.85642481
95	MP0003633_abnormal_nervous_system	0.83385717
96	MP0002210_abnormal_sex_determination	0.82805353
97	MP0002752_abnormal_somatic_nervous	0.82601827
98	MP0002132_abnormal_respiratory_system	0.82508904
99	MP0001986_abnormal_taste_sensitivity	0.80519593
100	MP0004085_abnormal_heartbeat	0.80264461

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.02518021
2	Intestinal atresia (HP:0011100)	3.75268636
3	True hermaphroditism (HP:0010459)	3.67951228
4	Hypothermia (HP:0002045)	3.65826838
5	Methylmalonic acidemia (HP:0002912)	3.55205358
6	Pancreatic cysts (HP:0001737)	3.42901983
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.26438317
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.26438317
9	Acute necrotizing encephalopathy (HP:0006965)	3.23619133
10	Progressive macrocephaly (HP:0004481)	3.16151990
11	Hyperventilation (HP:0002883)	3.10643974
12	Medial flaring of the eyebrow (HP:0010747)	3.10555984
13	Abnormality of vitamin B metabolism (HP:0004340)	2.97060923
14	Acute encephalopathy (HP:0006846)	2.91785082
15	Nephronophthisis (HP:0000090)	2.85212329
16	Mitochondrial inheritance (HP:0001427)	2.84594487
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.74392961
18	Methylmalonic aciduria (HP:0012120)	2.74027506
19	Occipital encephalocele (HP:0002085)	2.73166498
20	Gaze-evoked nystagmus (HP:0000640)	2.69628197
21	Gait imbalance (HP:0002141)	2.66383394
22	Molar tooth sign on MRI (HP:0002419)	2.65464499
23	Abnormality of midbrain morphology (HP:0002418)	2.65464499
24	Abnormality of the renal cortex (HP:0011035)	2.65226514
25	Congenital primary aphakia (HP:0007707)	2.61752205
26	Lipid accumulation in hepatocytes (HP:0006561)	2.55952418
27	Nephrogenic diabetes insipidus (HP:0009806)	2.55742887
28	Hepatic necrosis (HP:0002605)	2.52994824
29	Type II lissencephaly (HP:0007260)	2.52912379
30	Absent speech (HP:0001344)	2.47965538
31	Hepatocellular necrosis (HP:0001404)	2.43672440
32	Male pseudohermaphroditism (HP:0000037)	2.42881223
33	3-Methylglutaconic aciduria (HP:0003535)	2.40080522
34	Abnormality of the renal medulla (HP:0100957)	2.39115879
35	Increased CSF lactate (HP:0002490)	2.36531725
36	Optic nerve hypoplasia (HP:0000609)	2.33786587
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.30012371
38	Tubulointerstitial nephritis (HP:0001970)	2.27924042
39	Cystic liver disease (HP:0006706)	2.24753150
40	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.23394244
41	Pachygyria (HP:0001302)	2.23034189
42	Abnormal hair whorl (HP:0010721)	2.20877047
43	Increased hepatocellular lipid droplets (HP:0006565)	2.20702510
44	Gastrointestinal atresia (HP:0002589)	2.20623386
45	Genital tract atresia (HP:0001827)	2.19396907
46	Renal cortical cysts (HP:0000803)	2.17790546
47	Sclerocornea (HP:0000647)	2.14830667
48	Arthropathy (HP:0003040)	2.12603497
49	Glycosuria (HP:0003076)	2.12598383
50	Abnormality of urine glucose concentration (HP:0011016)	2.12598383
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.12150523
52	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.11574876
53	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.11574876
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11551863
55	Median cleft lip (HP:0000161)	2.10984231
56	Chronic hepatic failure (HP:0100626)	2.10148419
57	Tubular atrophy (HP:0000092)	2.09941151
58	Renal Fanconi syndrome (HP:0001994)	2.06421777
59	Hypoplasia of the uterus (HP:0000013)	2.06211587
60	Abnormality of vitamin metabolism (HP:0100508)	2.05901071
61	Congenital sensorineural hearing impairment (HP:0008527)	2.04753654
62	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04122513
63	Inability to walk (HP:0002540)	2.00966377
64	Cerebral edema (HP:0002181)	2.00629364
65	Urethral obstruction (HP:0000796)	1.99907727
66	Postaxial hand polydactyly (HP:0001162)	1.99884971
67	Hemiparesis (HP:0001269)	1.99293895
68	Lissencephaly (HP:0001339)	1.98689910
69	Polydipsia (HP:0001959)	1.95947212
70	Abnormal drinking behavior (HP:0030082)	1.95947212
71	Amblyopia (HP:0000646)	1.93871867
72	Vaginal atresia (HP:0000148)	1.93327080
73	Cerebellar dysplasia (HP:0007033)	1.93017373
74	Progressive inability to walk (HP:0002505)	1.89875778
75	Poor coordination (HP:0002370)	1.89747601
76	Congenital malformation of the right heart (HP:0011723)	1.89277627
77	Double outlet right ventricle (HP:0001719)	1.89277627
78	Hyperglycinemia (HP:0002154)	1.88990288
79	Atonic seizures (HP:0010819)	1.88727427
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86718932
81	Reduced antithrombin III activity (HP:0001976)	1.85805978
82	Postaxial foot polydactyly (HP:0001830)	1.83448896
83	Retinal dysplasia (HP:0007973)	1.83084058
84	Urinary urgency (HP:0000012)	1.82794573
85	Respiratory failure (HP:0002878)	1.79958184
86	Congenital hepatic fibrosis (HP:0002612)	1.79763908
87	Dicarboxylic aciduria (HP:0003215)	1.78379268
88	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.78379268
89	Testicular atrophy (HP:0000029)	1.77927447
90	Pendular nystagmus (HP:0012043)	1.77557423
91	Lactic acidosis (HP:0003128)	1.77141845
92	Polyphagia (HP:0002591)	1.76686484
93	Azoospermia (HP:0000027)	1.76401539
94	Drooling (HP:0002307)	1.75921384
95	Severe muscular hypotonia (HP:0006829)	1.75114974
96	Abnormality of the labia minora (HP:0012880)	1.74555855
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.74452950
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.74452950
99	Degeneration of anterior horn cells (HP:0002398)	1.74414698
100	Abnormality of the anterior horn cell (HP:0006802)	1.74414698

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.77557173
2	PINK1	4.57384966
3	CASK	3.77324482
4	MAP2K7	3.51874642
5	MAP4K2	3.25247139
6	WNK3	3.07238950
7	MAP3K4	2.78280068
8	MAPK13	2.28145575
9	BCR	2.13666529
10	CSNK1G3	2.01879811
11	GRK1	2.01526711
12	CSNK1G2	1.97011628
13	TRIM28	1.87972928
14	CSNK1G1	1.84694728
15	PRKD3	1.82613138
16	ZAK	1.76574748
17	PHKG1	1.65969333
18	PHKG2	1.65969333
19	ADRBK2	1.64175012
20	MARK1	1.58304928
21	MYLK	1.57591393
22	PAK3	1.57342411
23	MARK3	1.54916452
24	STK38L	1.33653623
25	BCKDK	1.33479514
26	DYRK2	1.31896098
27	ERBB3	1.25834306
28	DYRK3	1.22741312
29	CSNK1A1L	1.20946871
30	TNIK	1.19918603
31	FGFR2	1.12001350
32	PRKCG	1.07803589
33	LMTK2	1.06929329
34	INSRR	1.06903562
35	MKNK2	1.05659216
36	PRKCE	1.04279227
37	PLK2	0.97578061
38	PKN1	0.96322502
39	TLK1	0.96184741
40	BMPR1B	0.93400280
41	EPHA3	0.90399750
42	MAP2K4	0.86225532
43	STK4	0.84059648
44	RPS6KA5	0.81691455
45	CCNB1	0.79854617
46	WNK4	0.79514360
47	PLK4	0.76732424
48	OBSCN	0.76607734
49	SGK494	0.76336514
50	SGK223	0.76336514
51	NEK2	0.75176945
52	EPHA4	0.70856912
53	VRK1	0.69340592
54	FLT3	0.67802723
55	NUAK1	0.64728240
56	FER	0.62784356
57	CSNK1A1	0.62596695
58	NTRK2	0.62232902
59	MKNK1	0.59832543
60	PRKG1	0.59566946
61	PRKAA1	0.59016371
62	MST4	0.58890512
63	STK3	0.58408177
64	STK24	0.56945162
65	TAF1	0.56193874
66	PLK3	0.52894470
67	GRK5	0.51777205
68	CAMK2A	0.50704930
69	PLK1	0.50273961
70	TIE1	0.44068630
71	TAOK1	0.43844426
72	PTK2B	0.43697836
73	ATM	0.43440508
74	PRKACB	0.43281920
75	RPS6KA4	0.42534896
76	SGK2	0.42276349
77	ROCK1	0.41814666
78	ILK	0.41060929
79	PRKACA	0.40673989
80	PRKD2	0.38729885
81	CAMK2D	0.38031503
82	PRKCQ	0.36902495
83	NME1	0.34751696
84	DAPK2	0.33817857
85	BRSK2	0.33787051
86	DYRK1A	0.33016201
87	MAPK15	0.31692259
88	PRKG2	0.31568593
89	ADRBK1	0.31050796
90	NTRK1	0.31013479
91	PRKCZ	0.30683549
92	CDK5	0.30345557
93	OXSR1	0.30332069
94	CSNK1D	0.30178417
95	CSNK1E	0.29691282
96	NTRK3	0.29386121
97	MINK1	0.28807386
98	LIMK1	0.28100188
99	MAP2K6	0.26842226
100	WEE1	0.25999601

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.76592063
2	Protein export_Homo sapiens_hsa03060	3.03236796
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.76209791
4	Butanoate metabolism_Homo sapiens_hsa00650	2.74485086
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.65660433
6	Propanoate metabolism_Homo sapiens_hsa00640	2.55513493
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.54555811
8	Parkinsons disease_Homo sapiens_hsa05012	2.23117258
9	RNA polymerase_Homo sapiens_hsa03020	2.16582187
10	Nicotine addiction_Homo sapiens_hsa05033	2.09456412
11	Basal transcription factors_Homo sapiens_hsa03022	1.87024809
12	Peroxisome_Homo sapiens_hsa04146	1.72690581
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70956584
14	Phototransduction_Homo sapiens_hsa04744	1.70676836
15	Folate biosynthesis_Homo sapiens_hsa00790	1.66670069
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63558973
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.61623348
18	GABAergic synapse_Homo sapiens_hsa04727	1.50617901
19	Insulin secretion_Homo sapiens_hsa04911	1.44773219
20	Sulfur metabolism_Homo sapiens_hsa00920	1.43760955
21	Olfactory transduction_Homo sapiens_hsa04740	1.43331447
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37060377
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.33882985
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.31889838
25	Circadian entrainment_Homo sapiens_hsa04713	1.27584847
26	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.26668969
27	Alzheimers disease_Homo sapiens_hsa05010	1.26491798
28	Morphine addiction_Homo sapiens_hsa05032	1.23959693
29	Taste transduction_Homo sapiens_hsa04742	1.21190604
30	Huntingtons disease_Homo sapiens_hsa05016	1.19422530
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16551298
32	Dopaminergic synapse_Homo sapiens_hsa04728	1.15486956
33	Homologous recombination_Homo sapiens_hsa03440	1.14296141
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13444018
35	RNA degradation_Homo sapiens_hsa03018	1.12071597
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.09028676
37	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.08598336
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.07175789
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.07175777
40	Purine metabolism_Homo sapiens_hsa00230	1.06838318
41	Circadian rhythm_Homo sapiens_hsa04710	1.06532377
42	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03768513
43	Oocyte meiosis_Homo sapiens_hsa04114	1.03019393
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02145585
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01786685
46	Selenocompound metabolism_Homo sapiens_hsa00450	1.00056484
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.99375935
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.98343198
49	Regulation of autophagy_Homo sapiens_hsa04140	0.93777216
50	Fatty acid elongation_Homo sapiens_hsa00062	0.93408621
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93382786
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90989262
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90298111
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89694276
55	Metabolic pathways_Homo sapiens_hsa01100	0.89420685
56	Retinol metabolism_Homo sapiens_hsa00830	0.87523777
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85858823
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84817143
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84481630
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83630668
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.81105975
62	Amphetamine addiction_Homo sapiens_hsa05031	0.80480490
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78122032
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.77248012
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76761335
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76276379
67	ABC transporters_Homo sapiens_hsa02010	0.75530407
68	Glutathione metabolism_Homo sapiens_hsa00480	0.74207957
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.72755865
70	Gap junction_Homo sapiens_hsa04540	0.71919086
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69712539
72	Vibrio cholerae infection_Homo sapiens_hsa05110	0.67527433
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67281845
74	Serotonergic synapse_Homo sapiens_hsa04726	0.66111952
75	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62723275
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62495149
77	Alcoholism_Homo sapiens_hsa05034	0.60555873
78	Renin secretion_Homo sapiens_hsa04924	0.59990384
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59497457
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57291015
81	Cocaine addiction_Homo sapiens_hsa05030	0.57059390
82	Salivary secretion_Homo sapiens_hsa04970	0.53252354
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.52321755
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52122312
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.50661844
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.49971612
87	Fatty acid degradation_Homo sapiens_hsa00071	0.46013797
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45986206
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45405808
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.43261657
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41433118
92	Arginine biosynthesis_Homo sapiens_hsa00220	0.41401872
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.40260558
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40234883
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39990152
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39258367
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.39228604
98	Gastric acid secretion_Homo sapiens_hsa04971	0.38337615
99	Glucagon signaling pathway_Homo sapiens_hsa04922	0.35521629
100	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.34285816

UBE2Q2L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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