UBE2QL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.27458779
2synaptic vesicle maturation (GO:0016188)5.96285703
3vocalization behavior (GO:0071625)5.95891830
4locomotory exploration behavior (GO:0035641)5.82277644
5synaptic vesicle exocytosis (GO:0016079)5.63425085
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.62756625
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.59371857
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55505375
9glutamate secretion (GO:0014047)5.35019127
10neuron cell-cell adhesion (GO:0007158)5.20981010
11protein localization to synapse (GO:0035418)5.17576044
12regulation of glutamate receptor signaling pathway (GO:1900449)5.17416076
13regulation of synaptic vesicle exocytosis (GO:2000300)5.08028582
14layer formation in cerebral cortex (GO:0021819)4.97537865
15exploration behavior (GO:0035640)4.88618252
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.86810908
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.81595511
18neurotransmitter secretion (GO:0007269)4.63814989
19regulation of synaptic vesicle transport (GO:1902803)4.50435048
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49248082
21regulation of neuronal synaptic plasticity (GO:0048168)4.40547232
22dendritic spine morphogenesis (GO:0060997)4.37390556
23glutamate receptor signaling pathway (GO:0007215)4.33167948
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.28927424
25neuronal action potential propagation (GO:0019227)4.27554815
26neuron recognition (GO:0008038)4.22420068
27synaptic transmission, glutamatergic (GO:0035249)4.21673852
28regulation of synapse structural plasticity (GO:0051823)4.21027185
29neurotransmitter-gated ion channel clustering (GO:0072578)4.14806405
30proline transport (GO:0015824)4.14778700
31positive regulation of synapse maturation (GO:0090129)4.03087740
32gamma-aminobutyric acid transport (GO:0015812)4.02394877
33neuron-neuron synaptic transmission (GO:0007270)3.97191990
34postsynaptic membrane organization (GO:0001941)3.83320954
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.83011063
36axonal fasciculation (GO:0007413)3.79323962
37membrane depolarization during action potential (GO:0086010)3.78817985
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.77723620
39long-term memory (GO:0007616)3.76070967
40positive regulation of membrane potential (GO:0045838)3.74877871
41neurotransmitter transport (GO:0006836)3.71836542
42regulation of dendritic spine morphogenesis (GO:0061001)3.67849744
43synaptic vesicle endocytosis (GO:0048488)3.64276743
44regulation of postsynaptic membrane potential (GO:0060078)3.62225411
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.61354806
46cellular potassium ion homeostasis (GO:0030007)3.58505465
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55672138
48regulation of synaptic plasticity (GO:0048167)3.53848715
49dendrite morphogenesis (GO:0048813)3.50307809
50activation of protein kinase A activity (GO:0034199)3.50141822
51neuromuscular synaptic transmission (GO:0007274)3.49402738
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48927625
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.46546967
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44354518
55potassium ion import (GO:0010107)3.44302994
56transmission of nerve impulse (GO:0019226)3.44192799
57regulation of neurotransmitter levels (GO:0001505)3.43383010
58cell migration in hindbrain (GO:0021535)3.42401782
59regulation of neurotransmitter secretion (GO:0046928)3.41887826
60sodium ion export (GO:0071436)3.38577691
61neuronal ion channel clustering (GO:0045161)3.38477969
62cerebellar Purkinje cell layer development (GO:0021680)3.33613304
63long-term synaptic potentiation (GO:0060291)3.32351146
64potassium ion homeostasis (GO:0055075)3.31604546
65presynaptic membrane assembly (GO:0097105)3.30624330
66neuromuscular process controlling balance (GO:0050885)3.29286832
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29242685
68regulation of vesicle fusion (GO:0031338)3.28280249
69regulation of voltage-gated calcium channel activity (GO:1901385)3.28224736
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.25567559
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.23633882
72positive regulation of neurotransmitter secretion (GO:0001956)3.23242012
73negative regulation of microtubule polymerization (GO:0031115)3.21290896
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19990457
75cerebellar Purkinje cell differentiation (GO:0021702)3.19715889
76urinary tract smooth muscle contraction (GO:0014848)3.19647649
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18847715
78synapse assembly (GO:0007416)3.18510741
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17548122
80regulation of dendritic spine development (GO:0060998)3.17090668
81positive regulation of dendritic spine development (GO:0060999)3.16588883
82innervation (GO:0060384)3.16266390
83positive regulation of dendritic spine morphogenesis (GO:0061003)3.15770519
84detection of calcium ion (GO:0005513)3.15758753
85social behavior (GO:0035176)3.15639924
86intraspecies interaction between organisms (GO:0051703)3.15639924
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15547843
88cell communication by electrical coupling (GO:0010644)3.15503026
89auditory behavior (GO:0031223)3.14709673
90pyrimidine nucleobase catabolic process (GO:0006208)3.14005993
91regulation of synapse maturation (GO:0090128)3.12920126
92dendritic spine organization (GO:0097061)3.12795184
93presynaptic membrane organization (GO:0097090)3.11037670
94central nervous system projection neuron axonogenesis (GO:0021952)3.09246319
95membrane depolarization (GO:0051899)3.07249698
96central nervous system myelination (GO:0022010)3.07190181
97axon ensheathment in central nervous system (GO:0032291)3.07190181
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06914999
99regulation of neurotransmitter transport (GO:0051588)3.06653530
100learning (GO:0007612)3.06437818
101behavioral fear response (GO:0001662)3.05468304
102behavioral defense response (GO:0002209)3.05468304
103cerebellar granule cell differentiation (GO:0021707)3.05125933
104establishment of mitochondrion localization (GO:0051654)3.04703641
105serotonin metabolic process (GO:0042428)3.04262902
106vesicle transport along microtubule (GO:0047496)3.02106597
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01518309
108startle response (GO:0001964)3.01440951
109response to auditory stimulus (GO:0010996)2.99931091
110cellular sodium ion homeostasis (GO:0006883)2.99256413
111positive regulation of neurotransmitter transport (GO:0051590)2.98986656
112synapse organization (GO:0050808)2.98251093
113regulation of synaptic transmission (GO:0050804)2.98119232
114response to histamine (GO:0034776)2.97223664
115L-amino acid import (GO:0043092)2.96798179
116mechanosensory behavior (GO:0007638)2.96542642
117membrane hyperpolarization (GO:0060081)2.96360525
118organelle transport along microtubule (GO:0072384)2.96190491
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94721132
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.94473292
121synaptic transmission (GO:0007268)2.94382517
122cell differentiation in hindbrain (GO:0021533)2.94016320
123behavioral response to nicotine (GO:0035095)2.93391585
124mating behavior (GO:0007617)2.91565989
125regulation of cell communication by electrical coupling (GO:0010649)2.91224747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.36899492
2GBX2_23144817_ChIP-Seq_PC3_Human3.47071747
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.28434383
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24390342
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12041340
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85212662
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85212662
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.84868762
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77010113
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70520936
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.66515310
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62598331
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58456588
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57933045
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57141030
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.44724120
17DROSHA_22980978_ChIP-Seq_HELA_Human2.40054316
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39416856
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35493163
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.34659289
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34554551
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.30973268
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.27408022
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12157585
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07369282
26AR_21572438_ChIP-Seq_LNCaP_Human2.04950945
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89086999
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88990071
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88768499
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88093741
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86156757
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73805710
33TAF15_26573619_Chip-Seq_HEK293_Human1.73518532
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.63219800
35SMAD4_21799915_ChIP-Seq_A2780_Human1.59042208
36ZNF274_21170338_ChIP-Seq_K562_Hela1.56063297
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50893211
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43528366
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.43139201
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40809319
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39020360
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.38076061
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33958252
44P300_19829295_ChIP-Seq_ESCs_Human1.33409165
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.32714309
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32299963
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31283859
48* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29282845
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26864454
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26183243
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24950061
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.24671694
53AR_25329375_ChIP-Seq_VCAP_Human1.24338721
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.20963039
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20292127
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16855257
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16778645
58AR_19668381_ChIP-Seq_PC3_Human1.16043340
59RNF2_27304074_Chip-Seq_NSC_Mouse1.15445394
60IGF1R_20145208_ChIP-Seq_DFB_Human1.13477082
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12992216
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12822347
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12269787
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.10314203
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10140844
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09539247
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09456401
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09372180
69CTCF_27219007_Chip-Seq_Bcells_Human1.09151572
70STAT3_23295773_ChIP-Seq_U87_Human1.08855294
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08567017
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.05622723
73KDM2B_26808549_Chip-Seq_K562_Human1.04478732
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.03610891
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02689026
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01581871
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01152079
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00760206
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00721378
80TCF4_23295773_ChIP-Seq_U87_Human1.00042930
81AHR_22903824_ChIP-Seq_MCF-7_Human0.98494238
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98311711
83FUS_26573619_Chip-Seq_HEK293_Human0.98255010
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97112443
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.96996941
86GATA1_26923725_Chip-Seq_HPCs_Mouse0.95455064
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94126065
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93899635
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.93865758
90VDR_22108803_ChIP-Seq_LS180_Human0.93746393
91RUNX2_22187159_ChIP-Seq_PCA_Human0.93675664
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93497757
93JUN_21703547_ChIP-Seq_K562_Human0.93355812
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92755664
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92467356
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91664888
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91664888
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.91411191
99* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91021127
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89925912
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88552909
102ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87434438
103* TET1_21490601_ChIP-Seq_MESCs_Mouse0.85301071
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.85091271
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84184410
106* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83772247
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.83721497
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83631200
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83588499
110ER_23166858_ChIP-Seq_MCF-7_Human0.82543604
111* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80833643
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78185470
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77781870
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77658488
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77520169
116NANOG_18555785_Chip-Seq_ESCs_Mouse0.76899835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.62731486
2MP0003880_abnormal_central_pattern5.00079365
3MP0003635_abnormal_synaptic_transmissio4.25782388
4MP0004270_analgesia3.89810903
5MP0002063_abnormal_learning/memory/cond3.44252080
6MP0009745_abnormal_behavioral_response3.36993787
7MP0002064_seizures3.12558457
8MP0005423_abnormal_somatic_nervous3.08171972
9MP0001968_abnormal_touch/_nociception3.05044367
10MP0009046_muscle_twitch2.96530860
11MP0002572_abnormal_emotion/affect_behav2.80943479
12MP0002734_abnormal_mechanical_nocicepti2.80862265
13MP0001486_abnormal_startle_reflex2.51794795
14MP0002272_abnormal_nervous_system2.47667678
15MP0002735_abnormal_chemical_nociception2.40877475
16MP0002736_abnormal_nociception_after2.39306481
17MP0001440_abnormal_grooming_behavior2.29425773
18MP0002733_abnormal_thermal_nociception2.21002222
19MP0001501_abnormal_sleep_pattern2.18625794
20MP0000778_abnormal_nervous_system2.17666152
21MP0009780_abnormal_chondrocyte_physiolo2.13275155
22MP0002184_abnormal_innervation2.07302098
23MP0001970_abnormal_pain_threshold2.04639095
24MP0003329_amyloid_beta_deposits2.04146008
25MP0002067_abnormal_sensory_capabilities1.95515431
26MP0006276_abnormal_autonomic_nervous1.89431751
27MP0004811_abnormal_neuron_physiology1.88127584
28MP0004858_abnormal_nervous_system1.88045561
29MP0002822_catalepsy1.86026466
30MP0002557_abnormal_social/conspecific_i1.82251730
31MP0008569_lethality_at_weaning1.76467883
32MP0003123_paternal_imprinting1.74569262
33MP0004924_abnormal_behavior1.72759682
34MP0005386_behavior/neurological_phenoty1.72759682
35MP0000955_abnormal_spinal_cord1.70832354
36MP0002909_abnormal_adrenal_gland1.66517414
37MP0004885_abnormal_endolymph1.57591337
38MP0003879_abnormal_hair_cell1.54923654
39MP0002882_abnormal_neuron_morphology1.49417219
40MP0002066_abnormal_motor_capabilities/c1.46673321
41MP0001984_abnormal_olfaction1.46203005
42MP0003787_abnormal_imprinting1.33927068
43MP0005646_abnormal_pituitary_gland1.33779708
44MP0005645_abnormal_hypothalamus_physiol1.30898037
45MP0004142_abnormal_muscle_tone1.30696625
46MP0003633_abnormal_nervous_system1.20387292
47MP0001905_abnormal_dopamine_level1.20083310
48MP0001529_abnormal_vocalization1.20057728
49MP0002152_abnormal_brain_morphology1.19770120
50MP0001502_abnormal_circadian_rhythm1.19613620
51MP0003121_genomic_imprinting1.18958380
52MP0003122_maternal_imprinting1.18798139
53MP0000569_abnormal_digit_pigmentation1.15581520
54MP0000751_myopathy1.13845427
55MP0000566_synostosis1.11227249
56MP0003631_nervous_system_phenotype1.06796056
57MP0002837_dystrophic_cardiac_calcinosis1.02750476
58MP0001188_hyperpigmentation0.98190343
59MP0004742_abnormal_vestibular_system0.93769815
60MP0002069_abnormal_eating/drinking_beha0.92805549
61MP0000604_amyloidosis0.92411902
62MP0002229_neurodegeneration0.90228466
63MP0005394_taste/olfaction_phenotype0.89509111
64MP0005499_abnormal_olfactory_system0.89509111
65MP0004145_abnormal_muscle_electrophysio0.88982765
66MP0008877_abnormal_DNA_methylation0.87307598
67MP0008872_abnormal_physiological_respon0.85769795
68MP0003634_abnormal_glial_cell0.84744505
69MP0004085_abnormal_heartbeat0.84088435
70MP0001963_abnormal_hearing_physiology0.83413748
71MP0002752_abnormal_somatic_nervous0.82552106
72MP0008874_decreased_physiological_sensi0.80618623
73MP0001177_atelectasis0.80574965
74MP0005535_abnormal_body_temperature0.80324356
75MP0003632_abnormal_nervous_system0.79078301
76MP0005551_abnormal_eye_electrophysiolog0.78528254
77MP0010386_abnormal_urinary_bladder0.78306118
78MP0000631_abnormal_neuroendocrine_gland0.77489153
79MP0004484_altered_response_of0.76407172
80MP0004215_abnormal_myocardial_fiber0.75461636
81MP0004233_abnormal_muscle_weight0.72046106
82MP0003137_abnormal_impulse_conducting0.71330661
83MP0003861_abnormal_nervous_system0.70656139
84MP0001986_abnormal_taste_sensitivity0.70002198
85MP0005187_abnormal_penis_morphology0.69204383
86MP0008961_abnormal_basal_metabolism0.68753569
87MP0000013_abnormal_adipose_tissue0.68008785
88MP0004043_abnormal_pH_regulation0.67830116
89MP0003283_abnormal_digestive_organ0.67543267
90MP0003075_altered_response_to0.66587859
91MP0001944_abnormal_pancreas_morphology0.65809322
92MP0000920_abnormal_myelination0.65207321
93MP0004510_myositis0.65026736
94MP0006072_abnormal_retinal_apoptosis0.63845123
95MP0005623_abnormal_meninges_morphology0.63595705
96MP0002090_abnormal_vision0.62296398
97MP0004133_heterotaxia0.61443168
98MP0004147_increased_porphyrin_level0.61236209
99MP0003646_muscle_fatigue0.60631901
100MP0002876_abnormal_thyroid_physiology0.59265081
101MP0001943_abnormal_respiration0.59171769
102MP0001346_abnormal_lacrimal_gland0.59056752
103MP0002638_abnormal_pupillary_reflex0.58976604
104MP0001664_abnormal_digestion0.58092764
105MP0003690_abnormal_glial_cell0.57154229
106MP0002082_postnatal_lethality0.56574100
107MP0005379_endocrine/exocrine_gland_phen0.55872876
108MP0001348_abnormal_lacrimal_gland0.55836092
109MP0001299_abnormal_eye_distance/0.55803220
110MP0004130_abnormal_muscle_cell0.54995399
111MP0010769_abnormal_survival0.54828456
112MP0005448_abnormal_energy_balance0.54536812
113MP0010768_mortality/aging0.54084524
114MP0001485_abnormal_pinna_reflex0.53707802
115MP0000026_abnormal_inner_ear0.53650112
116MP0010770_preweaning_lethality0.53617231

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.29826129
2Myokymia (HP:0002411)6.68926697
3Focal seizures (HP:0007359)5.69108775
4Visual hallucinations (HP:0002367)5.68913595
5Epileptic encephalopathy (HP:0200134)4.88178399
6Atonic seizures (HP:0010819)4.62281950
7Progressive cerebellar ataxia (HP:0002073)4.25866075
8Febrile seizures (HP:0002373)4.25557090
9Absence seizures (HP:0002121)4.17784483
10Supranuclear gaze palsy (HP:0000605)4.04326534
11Generalized tonic-clonic seizures (HP:0002069)3.80344278
12Dialeptic seizures (HP:0011146)3.78078781
13Mutism (HP:0002300)3.71729476
14Broad-based gait (HP:0002136)3.66522813
15Hyperventilation (HP:0002883)3.59894644
16Action tremor (HP:0002345)3.54118197
17Ankle clonus (HP:0011448)3.45779446
18Poor eye contact (HP:0000817)3.39543963
19Amblyopia (HP:0000646)3.24527965
20Papilledema (HP:0001085)3.21238584
21Impaired vibration sensation in the lower limbs (HP:0002166)3.20462567
22Cerebral inclusion bodies (HP:0100314)3.19651729
23Progressive inability to walk (HP:0002505)3.08746248
24Depression (HP:0000716)3.07899934
25Impaired social interactions (HP:0000735)3.07869894
26Abnormal social behavior (HP:0012433)3.07869894
27Drooling (HP:0002307)3.02410103
28Excessive salivation (HP:0003781)3.02410103
29Abnormal eating behavior (HP:0100738)3.01658572
30Urinary bladder sphincter dysfunction (HP:0002839)2.99198164
31Neurofibrillary tangles (HP:0002185)2.98129015
32Gaze-evoked nystagmus (HP:0000640)2.93746916
33Anxiety (HP:0000739)2.93468247
34Dysdiadochokinesis (HP:0002075)2.88129080
35Abnormality of the lower motor neuron (HP:0002366)2.83991648
36Dysmetria (HP:0001310)2.80751815
37Truncal ataxia (HP:0002078)2.78679780
38Amyotrophic lateral sclerosis (HP:0007354)2.78202383
39Urinary urgency (HP:0000012)2.77796381
40Abnormality of binocular vision (HP:0011514)2.75490508
41Diplopia (HP:0000651)2.75490508
42Genetic anticipation (HP:0003743)2.71254288
43Postural instability (HP:0002172)2.69998689
44Limb dystonia (HP:0002451)2.69073868
45Epileptiform EEG discharges (HP:0011182)2.65272768
46Hemiparesis (HP:0001269)2.64230704
47Polyphagia (HP:0002591)2.62446605
48Fetal akinesia sequence (HP:0001989)2.60414309
49Abnormality of the corticospinal tract (HP:0002492)2.59068118
50EEG with generalized epileptiform discharges (HP:0011198)2.58087908
51Torticollis (HP:0000473)2.56300865
52Termporal pattern (HP:0011008)2.56238060
53Insidious onset (HP:0003587)2.56238060
54Spastic gait (HP:0002064)2.50993925
55Hypsarrhythmia (HP:0002521)2.48481181
56Megalencephaly (HP:0001355)2.46765099
57Focal dystonia (HP:0004373)2.43010751
58Inability to walk (HP:0002540)2.42950437
59Impaired smooth pursuit (HP:0007772)2.39931821
60Bradykinesia (HP:0002067)2.38436648
61Absent speech (HP:0001344)2.38167643
62Stereotypic behavior (HP:0000733)2.37044326
63Pheochromocytoma (HP:0002666)2.32037191
64Cerebral hypomyelination (HP:0006808)2.31045114
65Agitation (HP:0000713)2.28302566
66Annular pancreas (HP:0001734)2.25582943
67Akinesia (HP:0002304)2.25220916
68Obstructive sleep apnea (HP:0002870)2.23259311
69Intention tremor (HP:0002080)2.23190855
70Lower limb muscle weakness (HP:0007340)2.18526445
71Generalized myoclonic seizures (HP:0002123)2.18161924
72Hemiplegia (HP:0002301)2.17118065
73Craniofacial dystonia (HP:0012179)2.14957814
74Bundle branch block (HP:0011710)2.14811188
75Inappropriate behavior (HP:0000719)2.14068540
76Status epilepticus (HP:0002133)2.13425283
77Prolonged QT interval (HP:0001657)2.13003911
78Ventricular fibrillation (HP:0001663)2.11430067
79Syncope (HP:0001279)2.09980989
80Hypoplasia of the brainstem (HP:0002365)2.09929537
81Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09929537
82Poor suck (HP:0002033)2.07735736
83Clonus (HP:0002169)2.07538078
84Delusions (HP:0000746)2.07391152
85Abnormal EKG (HP:0003115)2.06382859
86Scanning speech (HP:0002168)2.06314760
87Abnormality of ocular smooth pursuit (HP:0000617)2.05875971
88Insomnia (HP:0100785)2.05841822
89Impaired vibratory sensation (HP:0002495)2.05761230
90Rigidity (HP:0002063)2.03092096
91Degeneration of the lateral corticospinal tracts (HP:0002314)2.01278728
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01278728
93Muscular hypotonia of the trunk (HP:0008936)2.01147375
94Neuroendocrine neoplasm (HP:0100634)1.99966423
95Abnormality of salivation (HP:0100755)1.99419296
96Apathy (HP:0000741)1.98503776
97Sudden death (HP:0001699)1.96888884
98Spastic tetraplegia (HP:0002510)1.95400427
99Lower limb asymmetry (HP:0100559)1.93597149
100Rapidly progressive (HP:0003678)1.92723197
101Neoplasm of the peripheral nervous system (HP:0100007)1.88837093
102Incomplete penetrance (HP:0003829)1.87897519
103Peripheral hypomyelination (HP:0007182)1.85034642
104Dysmetric saccades (HP:0000641)1.84792502
105Pointed chin (HP:0000307)1.83869807
106Blue irides (HP:0000635)1.82911734
107Spastic tetraparesis (HP:0001285)1.82772301
108Tetraplegia (HP:0002445)1.82679885
109Neuronal loss in central nervous system (HP:0002529)1.82210113
110Sleep apnea (HP:0010535)1.82082385
111Psychosis (HP:0000709)1.81753916
112Gait ataxia (HP:0002066)1.81428761
113Gait imbalance (HP:0002141)1.81406187
114Specific learning disability (HP:0001328)1.79845477
115Morphological abnormality of the pyramidal tract (HP:0002062)1.77845498
116Sporadic (HP:0003745)1.75928742
117Diminished movement (HP:0002374)1.75312683
118Lower limb amyotrophy (HP:0007210)1.75252971
119Ulnar claw (HP:0001178)1.75141924
120Choreoathetosis (HP:0001266)1.73389492
121Myotonia (HP:0002486)1.71321103
122CNS hypomyelination (HP:0003429)1.69633609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.57722311
2NTRK34.08631759
3MAP3K94.00250428
4EPHA43.69828102
5MAP3K43.07866096
6MINK12.95232513
7MAP2K72.63971002
8DAPK22.47395119
9PAK62.39376829
10MAP3K122.23992100
11NTRK22.13287366
12KSR21.97672039
13MAP2K41.93586194
14CASK1.80650955
15KSR11.78722705
16CAMKK11.72529711
17PNCK1.71582275
18RIPK41.71058765
19PLK21.69934830
20SIK21.69857914
21NTRK11.67269247
22GRK51.66689660
23PRKD31.63978820
24MAPK131.62402351
25CDK51.56897682
26DAPK11.54708719
27LATS21.43266224
28PHKG21.38888042
29PHKG11.38888042
30CDK191.34956433
31PRKCG1.27013891
32TNIK1.24609240
33UHMK11.23311886
34OBSCN1.10047159
35STK381.09606073
36ARAF1.08382265
37PRPF4B1.01150516
38NME11.00628087
39TYRO30.98072538
40CAMK2A0.97621978
41FES0.96794131
42CDK180.95377138
43MAP3K20.95019292
44FGFR20.94754385
45CDK150.94122648
46CDK140.94083928
47PAK30.92180605
48STK110.90037832
49TAOK10.88593927
50DYRK1A0.88181985
51CSNK1G20.86938773
52CDK11A0.82809198
53RET0.80577116
54CAMK10.80382341
55CAMKK20.75826612
56RAF10.74899351
57PTK2B0.71428942
58CAMK2B0.69042575
59MARK20.67802110
60MAP3K130.66933104
61DYRK20.66369034
62RIPK10.65984889
63MAP3K110.63789252
64FRK0.63237931
65BMPR20.63180819
66PRKCZ0.62200781
67PRKCH0.61098410
68ALK0.60772972
69MAP3K60.60230231
70SGK4940.59992313
71SGK2230.59992313
72OXSR10.59944192
73FGR0.59154251
74LMTK20.57503221
75SGK10.56316141
76ERBB30.56255252
77PRKCE0.52708987
78PDK10.51439601
79MAPK120.50070165
80PINK10.47618640
81PKN10.47291652
82CCNB10.46626216
83CAMK1G0.46184630
84SCYL20.45752011
85PDPK10.45235159
86FYN0.45003910
87PRKG20.44179253
88PRKG10.43468762
89PRKACA0.43259508
90BRSK10.42798232
91RPS6KA30.42461604
92MAP2K60.41394750
93DAPK30.39997281
94MAP2K10.37884593
95SGK20.37547753
96WNK40.37369346
97LIMK10.36502615
98CAMK2G0.36112549
99MAPK100.35813336
100MAP3K10.35424038
101PRKAA10.35343688
102MAPK40.35317204
103RPS6KA20.35161091
104CAMK2D0.34650576
105ROCK20.34535945
106MAPKAPK50.34473953
107WNK30.34026868
108ADRBK20.32875680
109CSNK1D0.32600633
110CSNK1G30.32581041
111PRKCA0.32200529
112CSNK1E0.31942844
113SGK30.31823202
114TNK20.31305166
115CAMK40.31279807
116CDC42BPA0.31208346
117WNK10.31073861
118FER0.31047603
119MUSK0.30704815
120MAPK80.30611373

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.74355432
2Synaptic vesicle cycle_Homo sapiens_hsa047213.40130861
3GABAergic synapse_Homo sapiens_hsa047272.67144106
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65973854
5Long-term potentiation_Homo sapiens_hsa047202.65758476
6Circadian entrainment_Homo sapiens_hsa047132.62544171
7Olfactory transduction_Homo sapiens_hsa047402.62477974
8Glutamatergic synapse_Homo sapiens_hsa047242.55659514
9Morphine addiction_Homo sapiens_hsa050322.39727299
10Amphetamine addiction_Homo sapiens_hsa050312.33942715
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31900051
12Dopaminergic synapse_Homo sapiens_hsa047282.15745432
13Salivary secretion_Homo sapiens_hsa049702.12289593
14Cholinergic synapse_Homo sapiens_hsa047251.90930195
15Insulin secretion_Homo sapiens_hsa049111.88820714
16Gastric acid secretion_Homo sapiens_hsa049711.88054577
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76977898
18Taste transduction_Homo sapiens_hsa047421.76752915
19Long-term depression_Homo sapiens_hsa047301.73097220
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68388970
21Renin secretion_Homo sapiens_hsa049241.66322208
22Serotonergic synapse_Homo sapiens_hsa047261.66266833
23Oxytocin signaling pathway_Homo sapiens_hsa049211.64085632
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57706949
25Collecting duct acid secretion_Homo sapiens_hsa049661.54944438
26Calcium signaling pathway_Homo sapiens_hsa040201.50414659
27GnRH signaling pathway_Homo sapiens_hsa049121.45117544
28Gap junction_Homo sapiens_hsa045401.44199065
29Cocaine addiction_Homo sapiens_hsa050301.43641731
30Axon guidance_Homo sapiens_hsa043601.34999365
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34386209
32Vitamin B6 metabolism_Homo sapiens_hsa007501.33739935
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33087145
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24638313
35Glioma_Homo sapiens_hsa052141.24562112
36Cardiac muscle contraction_Homo sapiens_hsa042601.23607957
37Estrogen signaling pathway_Homo sapiens_hsa049151.19967484
38cAMP signaling pathway_Homo sapiens_hsa040241.17780743
39Type II diabetes mellitus_Homo sapiens_hsa049301.11872845
40ErbB signaling pathway_Homo sapiens_hsa040121.08879637
41Melanogenesis_Homo sapiens_hsa049161.07835249
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04414192
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03533110
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00031119
45Vibrio cholerae infection_Homo sapiens_hsa051100.97397118
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96704208
47Oocyte meiosis_Homo sapiens_hsa041140.89856671
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87143941
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.86225347
50Circadian rhythm_Homo sapiens_hsa047100.85831540
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.83939182
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.79312869
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77869952
54Phototransduction_Homo sapiens_hsa047440.77666078
55Dorso-ventral axis formation_Homo sapiens_hsa043200.76652671
56Alzheimers disease_Homo sapiens_hsa050100.75699626
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74679866
58Choline metabolism in cancer_Homo sapiens_hsa052310.73911662
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72391792
60Pancreatic secretion_Homo sapiens_hsa049720.71479120
61VEGF signaling pathway_Homo sapiens_hsa043700.71001202
62Dilated cardiomyopathy_Homo sapiens_hsa054140.70020008
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69973095
64Thyroid hormone synthesis_Homo sapiens_hsa049180.69044035
65MAPK signaling pathway_Homo sapiens_hsa040100.68967328
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.67590094
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66964152
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63309715
69Oxidative phosphorylation_Homo sapiens_hsa001900.61831178
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60369607
71Ras signaling pathway_Homo sapiens_hsa040140.60256855
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59280463
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58478039
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56595717
75Endometrial cancer_Homo sapiens_hsa052130.56285796
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.56131317
77Nitrogen metabolism_Homo sapiens_hsa009100.55393114
78Glucagon signaling pathway_Homo sapiens_hsa049220.55356790
79Rap1 signaling pathway_Homo sapiens_hsa040150.53669343
80Type I diabetes mellitus_Homo sapiens_hsa049400.51538046
81mTOR signaling pathway_Homo sapiens_hsa041500.51060106
82Renal cell carcinoma_Homo sapiens_hsa052110.50816760
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49282872
84Alcoholism_Homo sapiens_hsa050340.49044034
85Parkinsons disease_Homo sapiens_hsa050120.48716915
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48219301
87Endocytosis_Homo sapiens_hsa041440.47625848
88Wnt signaling pathway_Homo sapiens_hsa043100.45133485
89Insulin signaling pathway_Homo sapiens_hsa049100.44792292
90AMPK signaling pathway_Homo sapiens_hsa041520.42513712
91Non-small cell lung cancer_Homo sapiens_hsa052230.42090678
92Prion diseases_Homo sapiens_hsa050200.41245814
93Ovarian steroidogenesis_Homo sapiens_hsa049130.40739411
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40573974
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40540420
96Colorectal cancer_Homo sapiens_hsa052100.39503294
97Bile secretion_Homo sapiens_hsa049760.39473520
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38313513
99Regulation of autophagy_Homo sapiens_hsa041400.38013700
100Mineral absorption_Homo sapiens_hsa049780.37962576
101Inositol phosphate metabolism_Homo sapiens_hsa005620.37701892
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36464204
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36426554
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36376461
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35094868
106African trypanosomiasis_Homo sapiens_hsa051430.34629877
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33850620
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33503155
109Huntingtons disease_Homo sapiens_hsa050160.33328174
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32596891
111Butanoate metabolism_Homo sapiens_hsa006500.30774186
112Arginine and proline metabolism_Homo sapiens_hsa003300.29229376
113Arginine biosynthesis_Homo sapiens_hsa002200.26732586
114Tight junction_Homo sapiens_hsa045300.24951276

Most similar genes based on co-expression Upload to Enrichr

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