UBE2S

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.18498639
2protein localization to kinetochore (GO:0034501)4.60815251
3DNA replication-dependent nucleosome assembly (GO:0006335)4.59066335
4DNA replication-dependent nucleosome organization (GO:0034723)4.59066335
5protein localization to chromosome, centromeric region (GO:0071459)4.45359810
6mitotic sister chromatid segregation (GO:0000070)4.42359753
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.37436617
8DNA unwinding involved in DNA replication (GO:0006268)4.26388470
9nuclear pore organization (GO:0006999)4.26211910
10heterochromatin organization (GO:0070828)4.23354178
11nuclear pore complex assembly (GO:0051292)4.16035996
12mitotic nuclear envelope disassembly (GO:0007077)4.12861551
13mitotic metaphase plate congression (GO:0007080)4.04844429
14sister chromatid segregation (GO:0000819)4.04824900
15DNA replication initiation (GO:0006270)3.94035682
16regulation of mammary gland epithelial cell proliferation (GO:0033599)3.91998551
17nuclear envelope disassembly (GO:0051081)3.88401660
18membrane disassembly (GO:0030397)3.88401660
19folic acid-containing compound biosynthetic process (GO:0009396)3.86759951
20regulation of gene silencing by RNA (GO:0060966)3.86724333
21regulation of posttranscriptional gene silencing (GO:0060147)3.86724333
22regulation of gene silencing by miRNA (GO:0060964)3.86724333
23mitotic chromosome condensation (GO:0007076)3.75510522
24DNA strand elongation involved in DNA replication (GO:0006271)3.68128022
25establishment of integrated proviral latency (GO:0075713)3.66144180
26regulation of histone H3-K9 methylation (GO:0051570)3.65029593
27ribonucleoprotein complex biogenesis (GO:0022613)3.55284118
28formation of translation preinitiation complex (GO:0001731)3.51221769
29nuclear envelope reassembly (GO:0031468)3.50174475
30mitotic nuclear envelope reassembly (GO:0007084)3.50174475
31chromatin assembly (GO:0031497)3.47853389
32DNA strand elongation (GO:0022616)3.45616431
33positive regulation of chromosome segregation (GO:0051984)3.42711875
34metaphase plate congression (GO:0051310)3.41065252
35ribosomal small subunit assembly (GO:0000028)3.40027789
36pre-miRNA processing (GO:0031054)3.39553884
37chromosome condensation (GO:0030261)3.39268422
38DNA topological change (GO:0006265)3.36632656
39DNA replication checkpoint (GO:0000076)3.36206572
40synaptonemal complex assembly (GO:0007130)3.33863998
41negative regulation of histone methylation (GO:0031061)3.33013750
42protein localization to chromosome (GO:0034502)3.32785640
43regulation of chromosome segregation (GO:0051983)3.32178057
44protein complex localization (GO:0031503)3.32004254
45microtubule depolymerization (GO:0007019)3.30346781
46nucleobase-containing small molecule interconversion (GO:0015949)3.29910710
47proline biosynthetic process (GO:0006561)3.28914885
48regulation of spindle organization (GO:0090224)3.26568203
49maturation of SSU-rRNA (GO:0030490)3.25569955
50regulation of translational fidelity (GO:0006450)3.24574195
51viral transcription (GO:0019083)3.23011204
52viral mRNA export from host cell nucleus (GO:0046784)3.22775691
53establishment of chromosome localization (GO:0051303)3.21301863
54piRNA metabolic process (GO:0034587)3.21055914
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20649476
56ribosome biogenesis (GO:0042254)3.20238433
57chromatin assembly or disassembly (GO:0006333)3.20168952
58translational termination (GO:0006415)3.17890675
59gene silencing by RNA (GO:0031047)3.16700953
60pore complex assembly (GO:0046931)3.15789243
61cellular protein complex disassembly (GO:0043624)3.15330246
62viral life cycle (GO:0019058)3.14088209
63negative regulation of mRNA processing (GO:0050686)3.13335353
64regulation of sister chromatid cohesion (GO:0007063)3.13004420
65DNA duplex unwinding (GO:0032508)3.12644264
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11519469
67DNA geometric change (GO:0032392)3.11362078
68protein complex disassembly (GO:0043241)3.10864894
69spliceosomal tri-snRNP complex assembly (GO:0000244)3.10818198
70translational initiation (GO:0006413)3.10592555
71nuclear envelope organization (GO:0006998)3.10550899
72nucleosome disassembly (GO:0006337)3.09644783
73protein-DNA complex disassembly (GO:0032986)3.09644783
74histone H2A monoubiquitination (GO:0035518)3.09488016
75mitotic sister chromatid cohesion (GO:0007064)3.08859705
76telomere maintenance via semi-conservative replication (GO:0032201)3.07023814
77synaptonemal complex organization (GO:0070193)3.06324768
78negative regulation of RNA splicing (GO:0033119)3.05994648
79cellular protein complex localization (GO:0034629)3.04822940
80cotranslational protein targeting to membrane (GO:0006613)3.04528767
81histone exchange (GO:0043486)3.03515304
82chromatin remodeling at centromere (GO:0031055)3.03503085
83protein targeting to ER (GO:0045047)3.03250231
84regulation of telomere maintenance via telomerase (GO:0032210)3.01450169
85negative regulation of chromosome segregation (GO:0051985)3.00939647
86DNA packaging (GO:0006323)3.00794478
87translational elongation (GO:0006414)3.00045897
88peptidyl-arginine N-methylation (GO:0035246)2.99795057
89peptidyl-arginine methylation (GO:0018216)2.99795057
90establishment of viral latency (GO:0019043)2.99551018
91regulation of centrosome cycle (GO:0046605)2.98889461
92attachment of spindle microtubules to kinetochore (GO:0008608)2.95828892
93regulation of translational termination (GO:0006449)2.95761053
94rRNA transcription (GO:0009303)2.95457513
95positive regulation of mitotic sister chromatid separation (GO:1901970)2.95122805
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95122805
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95122805
98peptidyl-arginine omega-N-methylation (GO:0035247)2.94943691
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94734623
100regulation of chromatin binding (GO:0035561)2.93629187
101chromosome segregation (GO:0007059)2.93347047
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92559717
103negative regulation of mRNA metabolic process (GO:1903312)2.92079085
104telomere maintenance via recombination (GO:0000722)2.91566922
105binding of sperm to zona pellucida (GO:0007339)2.90903882
106macromolecular complex disassembly (GO:0032984)2.90461803
107DNA replication-independent nucleosome organization (GO:0034724)2.90322435
108DNA replication-independent nucleosome assembly (GO:0006336)2.90322435
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89815107
110establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89618009
111somatic hypermutation of immunoglobulin genes (GO:0016446)2.88788403
112somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88788403
113regulation of mitotic spindle organization (GO:0060236)2.88708751
114DNA conformation change (GO:0071103)2.87995122
115positive regulation of DNA-dependent DNA replication (GO:2000105)2.87273381
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.86601838
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86601838
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86601838
119negative regulation of sister chromatid segregation (GO:0033046)2.86601838
120mRNA stabilization (GO:0048255)2.84496139
121RNA stabilization (GO:0043489)2.84496139
122spindle checkpoint (GO:0031577)2.84475623
123ATP-dependent chromatin remodeling (GO:0043044)2.82698832
124translesion synthesis (GO:0019985)2.82470164
125ribosomal large subunit biogenesis (GO:0042273)2.82346984
126negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81652379
127paraxial mesoderm development (GO:0048339)2.81221323
128male meiosis (GO:0007140)2.81200968
129protein localization to endoplasmic reticulum (GO:0070972)2.79585210
130gene silencing (GO:0016458)2.79253250
131mitotic recombination (GO:0006312)2.78412297
132CENP-A containing nucleosome assembly (GO:0034080)2.78386008
133regulation of centriole replication (GO:0046599)2.78355864
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77868536
135regulation of translational elongation (GO:0006448)2.76733695
136regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76106947
137nucleobase biosynthetic process (GO:0046112)2.75771981
138histone arginine methylation (GO:0034969)2.75740333
139L-serine metabolic process (GO:0006563)2.73637710
140pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.70987422
141DNA synthesis involved in DNA repair (GO:0000731)2.68822588
142rRNA processing (GO:0006364)2.67930435
143kinetochore organization (GO:0051383)2.63849631
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59783746
145positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.59632712
146protein localization to microtubule (GO:0035372)2.58735033
147COPI coating of Golgi vesicle (GO:0048205)2.58108888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.91360741
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.28749546
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.64338298
4* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.62662759
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42245305
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31334445
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18097327
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87775696
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43262610
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30061042
11MYC_22102868_ChIP-Seq_BL_Human2.29221877
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.24744422
13* XRN2_22483619_ChIP-Seq_HELA_Human2.09497810
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.04513172
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01995714
16AR_21909140_ChIP-Seq_LNCAP_Human1.91786475
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.90687945
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.86048211
19* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83855297
20NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83788615
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82937845
22POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74645350
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73276995
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.69995192
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65910849
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64700558
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62977936
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62977936
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62977936
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62506194
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62100160
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61578464
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60635626
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59551016
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54950259
36KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53207765
37LXR_22292898_ChIP-Seq_THP-1_Human1.50722253
38* TTF2_22483619_ChIP-Seq_HELA_Human1.49375868
39GABP_19822575_ChIP-Seq_HepG2_Human1.48329340
40VDR_21846776_ChIP-Seq_THP-1_Human1.48038264
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47470466
42VDR_23849224_ChIP-Seq_CD4+_Human1.47107693
43KDM5A_27292631_Chip-Seq_BREAST_Human1.46412183
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46272714
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45954789
46DCP1A_22483619_ChIP-Seq_HELA_Human1.45927047
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45748047
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44634298
49* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42860176
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41251797
51CIITA_25753668_ChIP-Seq_RAJI_Human1.39031726
52RACK7_27058665_Chip-Seq_MCF-7_Human1.38690240
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.38414757
54ZNF263_19887448_ChIP-Seq_K562_Human1.36206126
55FOXP3_21729870_ChIP-Seq_TREG_Human1.35312505
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34829433
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.34571588
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34220655
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33566030
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32670931
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32228740
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25979507
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25523658
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24503049
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22653881
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.22451336
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.22162550
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21089132
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19419896
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18505015
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17349917
72* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17100167
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16652216
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16561662
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15691145
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.12768474
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11105290
78P68_20966046_ChIP-Seq_HELA_Human1.10905648
79* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10813985
80* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10808204
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09691347
82TFEB_21752829_ChIP-Seq_HELA_Human1.09591217
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09183299
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08922388
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08118053
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07961362
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07163162
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06434365
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05349642
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05059596
91* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02762359
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02706331
93TCF7_22412390_ChIP-Seq_EML_Mouse1.02448968
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02404175
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01863385
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01473833
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01290186
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00566464
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.00356541
100ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99969942
101* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99850583
102TP63_17297297_ChIP-ChIP_HaCaT_Human0.99701151
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99026097
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95071161
105* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94566532
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94425589
107SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94190969
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93799874
109ATF3_27146783_Chip-Seq_COLON_Human0.93747844
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93061220
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92722791
112NCOR1_26117541_ChIP-Seq_K562_Human0.92340366
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.92240655
114* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91927320
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91642877
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91411539
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91408139
118SALL1_21062744_ChIP-ChIP_HESCs_Human0.90946449
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90412276
120KDM2B_26808549_Chip-Seq_DND41_Human0.88910450
121NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87757911
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.87493530
123UTX_26944678_Chip-Seq_JUKART_Human0.86872825
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86442148
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86078148
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86013697
127POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85425526
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83485308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.61837441
2MP0003111_abnormal_nucleus_morphology4.33723958
3MP0004957_abnormal_blastocyst_morpholog4.00146023
4MP0010094_abnormal_chromosome_stability3.88537145
5MP0003077_abnormal_cell_cycle3.60220215
6MP0008057_abnormal_DNA_replication2.87472307
7MP0002653_abnormal_ependyma_morphology2.76839815
8MP0001730_embryonic_growth_arrest2.49848880
9MP0010352_gastrointestinal_tract_polyps2.45935390
10MP0009379_abnormal_foot_pigmentation2.41136716
11MP0005410_abnormal_fertilization2.36946290
12MP0010307_abnormal_tumor_latency2.29978629
13MP0008877_abnormal_DNA_methylation2.27921644
14MP0008932_abnormal_embryonic_tissue2.26774960
15MP0008058_abnormal_DNA_repair2.24335408
16MP0000350_abnormal_cell_proliferation2.23301347
17MP0008007_abnormal_cellular_replicative2.13789345
18MP0003123_paternal_imprinting2.13518257
19MP0001346_abnormal_lacrimal_gland2.10866434
20MP0005076_abnormal_cell_differentiation2.00935619
21MP0003705_abnormal_hypodermis_morpholog1.97704553
22MP0005451_abnormal_body_composition1.96237470
23MP0001672_abnormal_embryogenesis/_devel1.95564440
24MP0005380_embryogenesis_phenotype1.95564440
25MP0002085_abnormal_embryonic_tissue1.94115699
26MP0001697_abnormal_embryo_size1.92540305
27MP0001929_abnormal_gametogenesis1.90522223
28MP0002084_abnormal_developmental_patter1.90474393
29MP0010030_abnormal_orbit_morphology1.83179386
30MP0002210_abnormal_sex_determination1.81959236
31MP0003984_embryonic_growth_retardation1.70933752
32MP0002080_prenatal_lethality1.70744385
33MP0004197_abnormal_fetal_growth/weight/1.69433042
34MP0002088_abnormal_embryonic_growth/wei1.68233459
35MP0009278_abnormal_bone_marrow1.65832295
36MP0002086_abnormal_extraembryonic_tissu1.65486231
37MP0000678_abnormal_parathyroid_gland1.61232814
38MP0001145_abnormal_male_reproductive1.59905941
39MP0000490_abnormal_crypts_of1.50901595
40MP0003786_premature_aging1.50264414
41MP0004858_abnormal_nervous_system1.43861980
42MP0002163_abnormal_gland_morphology1.41700254
43MP0003698_abnormal_male_reproductive1.40138646
44MP0003119_abnormal_digestive_system1.35719678
45MP0000653_abnormal_sex_gland1.34813015
46MP0000313_abnormal_cell_death1.33497617
47MP0002019_abnormal_tumor_incidence1.30307956
48MP0003718_maternal_effect1.29078866
49MP0001849_ear_inflammation1.29047631
50MP0003942_abnormal_urinary_system1.26760317
51MP0001293_anophthalmia1.25793192
52MP0000537_abnormal_urethra_morphology1.24293336
53MP0000049_abnormal_middle_ear1.22555707
54MP0004808_abnormal_hematopoietic_stem1.18612270
55MP0000003_abnormal_adipose_tissue1.15741466
56MP0006292_abnormal_olfactory_placode1.15714422
57MP0003567_abnormal_fetal_cardiomyocyte1.13379277
58MP0002089_abnormal_postnatal_growth/wei1.12256416
59MP0003646_muscle_fatigue1.11602377
60MP0009053_abnormal_anal_canal1.11032223
61MP0003890_abnormal_embryonic-extraembry1.09485214
62MP0004233_abnormal_muscle_weight1.08750706
63MP0004185_abnormal_adipocyte_glucose1.08493931
64MP0003303_peritoneal_inflammation1.07496946
65MP0001348_abnormal_lacrimal_gland1.06577941
66MP0005397_hematopoietic_system_phenotyp1.05886613
67MP0001545_abnormal_hematopoietic_system1.05886613
68MP0000733_abnormal_muscle_development1.05842739
69MP0009250_abnormal_appendicular_skeleto1.05438077
70MP0003385_abnormal_body_wall1.05220802
71MP0005257_abnormal_intraocular_pressure1.04959018
72MP0000566_synostosis1.04837457
73MP0002161_abnormal_fertility/fecundity1.04608303
74MP0004133_heterotaxia1.04396747
75MP0003453_abnormal_keratinocyte_physiol1.03658086
76MP0001915_intracranial_hemorrhage1.03562665
77MP0002160_abnormal_reproductive_system1.02467911
78MP0003566_abnormal_cell_adhesion1.01394068
79MP0005623_abnormal_meninges_morphology1.00312720
80MP0005666_abnormal_adipose_tissue1.00126313
81MP0003315_abnormal_perineum_morphology0.98838170
82MP0001188_hyperpigmentation0.98614849
83MP0003121_genomic_imprinting0.98329304
84MP0000534_abnormal_ureter_morphology0.96483488
85MP0003937_abnormal_limbs/digits/tail_de0.94746909
86MP0002396_abnormal_hematopoietic_system0.94286508
87MP0002796_impaired_skin_barrier0.92799855
88MP0000703_abnormal_thymus_morphology0.91333403
89MP0000358_abnormal_cell_content/0.90816933
90MP0000762_abnormal_tongue_morphology0.90537147
91MP0002092_abnormal_eye_morphology0.89984484
92MP0002111_abnormal_tail_morphology0.89300612
93MP0000858_altered_metastatic_potential0.88856701
94MP0009672_abnormal_birth_weight0.87900991
95MP0005375_adipose_tissue_phenotype0.87600001
96MP0000428_abnormal_craniofacial_morphol0.85388347
97MP0002697_abnormal_eye_size0.84808849
98MP0003115_abnormal_respiratory_system0.84454220
99MP0002234_abnormal_pharynx_morphology0.83264000
100MP0005023_abnormal_wound_healing0.81970843
101MP0002877_abnormal_melanocyte_morpholog0.81533357
102MP0001661_extended_life_span0.80272830
103MP0001286_abnormal_eye_development0.80257640
104MP0005621_abnormal_cell_physiology0.79920991
105MP0003861_abnormal_nervous_system0.79688099
106MP0009703_decreased_birth_body0.79097813
107MP0002114_abnormal_axial_skeleton0.78315585
108MP0000432_abnormal_head_morphology0.78176254
109MP0008770_decreased_survivor_rate0.77886336
110MP0009333_abnormal_splenocyte_physiolog0.77748731
111MP0003755_abnormal_palate_morphology0.77446914
112MP0010234_abnormal_vibrissa_follicle0.75982564
113MP0005384_cellular_phenotype0.75928752
114MP0002282_abnormal_trachea_morphology0.75611936
115MP0002925_abnormal_cardiovascular_devel0.74947552
116MP0003935_abnormal_craniofacial_develop0.73889945
117MP0001119_abnormal_female_reproductive0.73732118
118MP0004272_abnormal_basement_membrane0.73126045
119MP0002081_perinatal_lethality0.72097459
120MP0005389_reproductive_system_phenotype0.70645621
121MP0002116_abnormal_craniofacial_bone0.70082267
122MP0006035_abnormal_mitochondrial_morpho0.69356749
123MP0003699_abnormal_female_reproductive0.69045002
124MP0005501_abnormal_skin_physiology0.69012924
125MP0003448_altered_tumor_morphology0.67108945
126MP0001881_abnormal_mammary_gland0.66348177
127MP0001340_abnormal_eyelid_morphology0.66206766
128MP0000750_abnormal_muscle_regeneration0.65743982
129MP0000477_abnormal_intestine_morphology0.65245020
130MP0002249_abnormal_larynx_morphology0.64825175
131MP0002398_abnormal_bone_marrow0.64395935
132MP0002722_abnormal_immune_system0.63993918
133MP0003283_abnormal_digestive_organ0.62969408

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.74846603
2Aplasia/Hypoplasia of the sacrum (HP:0008517)3.65759879
3Broad distal phalanx of finger (HP:0009836)3.62561571
4Selective tooth agenesis (HP:0001592)3.53596128
5Reticulocytopenia (HP:0001896)3.30760127
6Breast hypoplasia (HP:0003187)3.30304596
7Birth length less than 3rd percentile (HP:0003561)3.29039083
8Ulnar bowing (HP:0003031)3.19195621
9Progressive muscle weakness (HP:0003323)3.09076345
10Patellar aplasia (HP:0006443)3.07596052
11Medulloblastoma (HP:0002885)2.99438674
12Impulsivity (HP:0100710)2.90921074
13Aplasia/Hypoplasia of the patella (HP:0006498)2.89761808
14Insomnia (HP:0100785)2.83470760
15Achilles tendon contracture (HP:0001771)2.81445139
16Abnormality of cells of the erythroid lineage (HP:0012130)2.78914632
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77364551
18Rhabdomyosarcoma (HP:0002859)2.73853692
19Absent thumb (HP:0009777)2.71145898
20Astrocytoma (HP:0009592)2.70355832
21Abnormality of the astrocytes (HP:0100707)2.70355832
22Abnormality of the phalanges of the hallux (HP:0010057)2.67243636
23Chromsome breakage (HP:0040012)2.66930361
24Colon cancer (HP:0003003)2.60618425
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.59904715
26Abnormality of the anterior horn cell (HP:0006802)2.59582097
27Degeneration of anterior horn cells (HP:0002398)2.59582097
28Basal cell carcinoma (HP:0002671)2.59565007
29Missing ribs (HP:0000921)2.54223441
30Male infertility (HP:0003251)2.51587267
31Absent radius (HP:0003974)2.49245872
32Abnormality of the umbilical cord (HP:0010881)2.48333059
33Neoplasm of striated muscle (HP:0009728)2.48236928
34Meckel diverticulum (HP:0002245)2.48071482
35Increased nuchal translucency (HP:0010880)2.42551315
36Rib fusion (HP:0000902)2.41932344
37Abnormal number of erythroid precursors (HP:0012131)2.41380756
38Abnormality of the ileum (HP:0001549)2.41113347
39Agnosia (HP:0010524)2.39542665
40Premature ovarian failure (HP:0008209)2.38024894
41Long palpebral fissure (HP:0000637)2.37269329
42Carpal bone hypoplasia (HP:0001498)2.37118544
43Abnormality of the fetal cardiovascular system (HP:0010948)2.37033650
44Abnormal umbilical cord blood vessels (HP:0011403)2.37033650
45Single umbilical artery (HP:0001195)2.37033650
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.36010122
47Atresia of the external auditory canal (HP:0000413)2.35306770
48Supernumerary spleens (HP:0009799)2.32891005
49Abnormality of the labia minora (HP:0012880)2.32279837
50Absent forearm bone (HP:0003953)2.32269017
51Aplasia involving forearm bones (HP:0009822)2.32269017
52Abnormality of the Achilles tendon (HP:0005109)2.31722352
53Overlapping toe (HP:0001845)2.30773396
54Neoplasm of the oral cavity (HP:0100649)2.29892589
55Microvesicular hepatic steatosis (HP:0001414)2.26792858
56Aplasia/hypoplasia of the humerus (HP:0006507)2.26624209
57Nasal polyposis (HP:0100582)2.24473931
58Neoplasm of the pancreas (HP:0002894)2.23397627
59Trismus (HP:0000211)2.23061189
60Duplication of thumb phalanx (HP:0009942)2.22862706
61Genu recurvatum (HP:0002816)2.21845087
62Overriding aorta (HP:0002623)2.21397152
63Proximal placement of thumb (HP:0009623)2.20722805
64High pitched voice (HP:0001620)2.19986548
65Abnormality of chromosome stability (HP:0003220)2.19229691
66Abdominal situs inversus (HP:0003363)2.19209266
67Abnormality of abdominal situs (HP:0011620)2.19209266
68Deviation of the thumb (HP:0009603)2.18508130
69Distal lower limb amyotrophy (HP:0008944)2.18076989
70Partial duplication of the phalanx of hand (HP:0009999)2.15480630
71Facial hemangioma (HP:0000329)2.13473774
72Small intestinal stenosis (HP:0012848)2.12637385
73Duodenal stenosis (HP:0100867)2.12637385
74Short 4th metacarpal (HP:0010044)2.12633914
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12633914
76Premature rupture of membranes (HP:0001788)2.12088129
77Abnormality of the distal phalanx of the thumb (HP:0009617)2.10595929
78Abnormality of the distal phalanges of the toes (HP:0010182)2.10109789
79Microretrognathia (HP:0000308)2.09801087
80Short humerus (HP:0005792)2.09533184
81Septate vagina (HP:0001153)2.09174279
82Sloping forehead (HP:0000340)2.08927317
83Elfin facies (HP:0004428)2.07300528
84Abnormality of the preputium (HP:0100587)2.07223441
85Glossoptosis (HP:0000162)2.06106053
86Oral leukoplakia (HP:0002745)2.05889209
87Cafe-au-lait spot (HP:0000957)2.04857206
88Hyperacusis (HP:0010780)2.04387589
89Tracheoesophageal fistula (HP:0002575)2.04128068
90Abnormal gallbladder physiology (HP:0012438)2.03750701
91Cholecystitis (HP:0001082)2.03750701
92Glioma (HP:0009733)2.03590017
93Myelodysplasia (HP:0002863)2.02630270
94Chronic bronchitis (HP:0004469)2.02240800
95Deep palmar crease (HP:0006191)2.01526727
96Biliary tract neoplasm (HP:0100574)2.01491105
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00963318
98Prominent nose (HP:0000448)2.00537630
99Squamous cell carcinoma (HP:0002860)1.98577860
100Disproportionate tall stature (HP:0001519)1.98509257
101Adenoma sebaceum (HP:0009720)1.97797028
102Angiofibromas (HP:0010615)1.97797028
103Patellar dislocation (HP:0002999)1.96456666
104Abnormality of the lower motor neuron (HP:0002366)1.95837999
105Heterotopia (HP:0002282)1.94767000
106Ectopic kidney (HP:0000086)1.94354949
107Macrocytic anemia (HP:0001972)1.93984531
108Multiple enchondromatosis (HP:0005701)1.91614670
10911 pairs of ribs (HP:0000878)1.91490011
110Partial duplication of thumb phalanx (HP:0009944)1.91471868
111Abnormality of the carotid arteries (HP:0005344)1.91055612
112Pallor (HP:0000980)1.90488957
113Abnormality of reticulocytes (HP:0004312)1.89616929
114Ragged-red muscle fibers (HP:0003200)1.89542302
115Truncus arteriosus (HP:0001660)1.89369317
116Malignant gastrointestinal tract tumors (HP:0006749)1.88092112
117Gastrointestinal carcinoma (HP:0002672)1.88092112
118Short nail (HP:0001799)1.86710076
119Secondary amenorrhea (HP:0000869)1.86123894
120Unilateral renal agenesis (HP:0000122)1.85499967
121Vaginal fistula (HP:0004320)1.84821436
122Renal duplication (HP:0000075)1.84788259
123Personality changes (HP:0000751)1.82841604
124Difficulty climbing stairs (HP:0003551)1.80750796
125Bowing of the arm (HP:0006488)1.80261961
126Bowed forearm bones (HP:0003956)1.80261961
127Rectovaginal fistula (HP:0000143)1.80154322
128Rectal fistula (HP:0100590)1.80154322
129Turricephaly (HP:0000262)1.80002020
130Shallow orbits (HP:0000586)1.79881799
131Rough bone trabeculation (HP:0100670)1.79628624
132Elbow flexion contracture (HP:0002987)1.79175862
133Reticulocytosis (HP:0001923)1.78773205
134Abnormal number of incisors (HP:0011064)1.77860026
135Esophageal atresia (HP:0002032)1.77039949
136Abnormality of the nasal mucosa (HP:0000433)1.77021322
137Cortical dysplasia (HP:0002539)1.76627025
138Intestinal fistula (HP:0100819)1.76453141
139Abnormality of the calcaneus (HP:0008364)1.76080529
140Slender long bone (HP:0003100)1.75937929
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.75667934
142Short thumb (HP:0009778)1.74468166
143Horseshoe kidney (HP:0000085)1.73730685
144Self-mutilation (HP:0000742)1.73112029
145Rectal prolapse (HP:0002035)1.72788317
146Abnormality of the duodenum (HP:0002246)1.72665600
147Coronal craniosynostosis (HP:0004440)1.72580382
148High anterior hairline (HP:0009890)1.72522297
149Abnormality of the 4th metacarpal (HP:0010012)1.71910562
150Abnormal lung lobation (HP:0002101)1.71812084
151Progressive external ophthalmoplegia (HP:0000590)1.70561905
152Spastic diplegia (HP:0001264)1.66456351
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64566407
154Testicular atrophy (HP:0000029)1.59692682
155Abnormalities of placenta or umbilical cord (HP:0001194)1.59029133
156Pointed chin (HP:0000307)1.58924393
157Poikiloderma (HP:0001029)1.58297350
158Lower limb amyotrophy (HP:0007210)1.57994830
159Abnormal ventriculo-arterial connection (HP:0011563)1.57415693
160Transposition of the great arteries (HP:0001669)1.57415693
161Abnormal connection of the cardiac segments (HP:0011545)1.57415693
162Abnormality of chromosome segregation (HP:0002916)1.56989760
163Back pain (HP:0003418)1.56819881
164Facial cleft (HP:0002006)1.56153647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK23.61765056
2CDC73.59709365
3BUB13.53377164
4EEF2K3.49041690
5SMG13.38859355
6CDK123.20978039
7WEE12.85426682
8IRAK32.84242232
9MAP3K102.68392762
10VRK22.59830223
11TTK2.53345965
12TLK12.34523097
13PKN22.26086862
14TRIB32.12593548
15ICK2.04493784
16TESK11.89823588
17PDK31.81158483
18PDK41.81158483
19RPS6KB21.76894933
20EPHA21.72640915
21PBK1.70811830
22PLK11.69328550
23TESK21.66209102
24CDK71.65734905
25DYRK31.61445017
26CHEK21.61118485
27NEK11.58709390
28SIK11.56310529
29CDK41.56178390
30PRPF4B1.56150893
31PASK1.53430761
32MAP3K81.51998921
33NME21.49849829
34AURKB1.42468159
35STK101.41849227
36SCYL21.40097178
37TAOK21.39791055
38RPS6KA41.35677581
39PAK41.35226946
40ARAF1.34495155
41PRKD31.31920640
42ATR1.28325147
43SRPK11.24965281
44CHEK11.24210660
45AURKA1.22111465
46LATS21.13618419
47PLK41.04921472
48EIF2AK11.04465099
49STK41.03436444
50STK31.02593875
51ALK1.01527631
52MAPKAPK30.99328437
53PIM10.98580320
54TAF10.98382529
55BRSK20.97667422
56LATS10.97381256
57MTOR0.95764732
58IRAK20.95341977
59ACVR1B0.94544386
60TSSK60.93697954
61CDK60.88969119
62PDK20.86095027
63TAOK10.85968657
64TYRO30.85698338
65CDK20.85606691
66ATM0.85002934
67BRD40.84290439
68PAK10.83413420
69MST1R0.83066151
70MAP3K90.82724102
71PIM20.80324976
72MKNK20.78074526
73PLK30.74097103
74BRSK10.71795067
75BMX0.71613336
76CDK90.71463334
77MAP3K60.70139974
78MELK0.68959050
79KDR0.68872631
80PTK20.68434136
81STK160.68238281
82STK38L0.67373662
83LRRK20.66774610
84CDK11A0.66737196
85TTN0.66079143
86ZAK0.65268805
87MKNK10.64962903
88TGFBR10.63230498
89FLT30.62677924
90CDK150.60197157
91CLK10.59333485
92BRAF0.59228207
93GRK60.58313659
94KSR20.58306760
95CDK80.57272658
96MAP3K110.56242661
97CDK10.55565890
98MAP2K30.54792548
99VRK10.53967611
100MOS0.53831855
101CDK180.53811319
102PRKCI0.53164068
103ILK0.52542944
104AKT20.51193684
105CDK140.50634299
106RPS6KA10.47939642
107PAK20.47832485
108RPS6KA50.47716960
109NME10.46030477
110MAP4K10.45694306
111MAP2K20.45622600
112NTRK10.45463946
113LIMK10.45265993
114LMTK20.44750415
115CSNK2A20.43499171
116PDGFRA0.42977205
117PTK60.40981439
118DAPK30.40652981
119DYRK1B0.40652857
120ABL20.40017377
121MAPK110.38999958
122ERBB40.37445873
123RPS6KC10.37351698
124MARK30.36032911
125CSNK2A10.34997928
126DYRK20.34371499
127CSNK1D0.33188017
128CSNK1E0.33135764
129PRKDC0.31762395
130PNCK0.30939116

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.21944375
2Mismatch repair_Homo sapiens_hsa034303.62863746
3RNA transport_Homo sapiens_hsa030133.32454176
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09477622
5Spliceosome_Homo sapiens_hsa030403.06837196
6Cell cycle_Homo sapiens_hsa041103.05099041
7Base excision repair_Homo sapiens_hsa034102.76608616
8Ribosome_Homo sapiens_hsa030102.61295082
9Nucleotide excision repair_Homo sapiens_hsa034202.47512346
10One carbon pool by folate_Homo sapiens_hsa006702.43362447
11mRNA surveillance pathway_Homo sapiens_hsa030152.36249902
12Homologous recombination_Homo sapiens_hsa034402.24024025
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15116681
14Fanconi anemia pathway_Homo sapiens_hsa034602.14660737
15RNA polymerase_Homo sapiens_hsa030202.10530306
16Systemic lupus erythematosus_Homo sapiens_hsa053222.01367888
17Basal transcription factors_Homo sapiens_hsa030221.97854361
18RNA degradation_Homo sapiens_hsa030181.69336531
19Pyrimidine metabolism_Homo sapiens_hsa002401.65850009
20p53 signaling pathway_Homo sapiens_hsa041151.65113178
21* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51509147
22Proteasome_Homo sapiens_hsa030501.47072543
23Oocyte meiosis_Homo sapiens_hsa041141.45726369
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43637340
25Viral carcinogenesis_Homo sapiens_hsa052031.41346599
26Non-homologous end-joining_Homo sapiens_hsa034501.35485065
27Vitamin B6 metabolism_Homo sapiens_hsa007501.28443308
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18966635
29MicroRNAs in cancer_Homo sapiens_hsa052061.15798936
30Bladder cancer_Homo sapiens_hsa052191.12376147
31Epstein-Barr virus infection_Homo sapiens_hsa051691.12281312
32Folate biosynthesis_Homo sapiens_hsa007901.11104220
33HTLV-I infection_Homo sapiens_hsa051661.09295168
34Small cell lung cancer_Homo sapiens_hsa052221.05779324
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05278864
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04272144
37Alcoholism_Homo sapiens_hsa050341.02364320
38Hippo signaling pathway_Homo sapiens_hsa043901.01908756
39mTOR signaling pathway_Homo sapiens_hsa041501.01239417
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00986745
41Chronic myeloid leukemia_Homo sapiens_hsa052201.00087710
42Herpes simplex infection_Homo sapiens_hsa051680.96496095
43Notch signaling pathway_Homo sapiens_hsa043300.96161144
44Basal cell carcinoma_Homo sapiens_hsa052170.93303504
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92864664
46Selenocompound metabolism_Homo sapiens_hsa004500.90569445
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.89761615
48Colorectal cancer_Homo sapiens_hsa052100.89480039
49Antigen processing and presentation_Homo sapiens_hsa046120.88249531
50Thyroid cancer_Homo sapiens_hsa052160.86891412
51Galactose metabolism_Homo sapiens_hsa000520.83928326
52N-Glycan biosynthesis_Homo sapiens_hsa005100.83727451
53Biosynthesis of amino acids_Homo sapiens_hsa012300.83359467
54TGF-beta signaling pathway_Homo sapiens_hsa043500.83162633
55Prion diseases_Homo sapiens_hsa050200.80701713
56Sulfur relay system_Homo sapiens_hsa041220.80700270
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77918225
58Purine metabolism_Homo sapiens_hsa002300.77114236
59Hedgehog signaling pathway_Homo sapiens_hsa043400.76706027
60Pentose phosphate pathway_Homo sapiens_hsa000300.75125371
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74203692
62Huntingtons disease_Homo sapiens_hsa050160.73389242
63Apoptosis_Homo sapiens_hsa042100.69367400
64Adherens junction_Homo sapiens_hsa045200.68997864
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67283762
66Pyruvate metabolism_Homo sapiens_hsa006200.64931337
67Non-small cell lung cancer_Homo sapiens_hsa052230.64655181
68Acute myeloid leukemia_Homo sapiens_hsa052210.63867530
69VEGF signaling pathway_Homo sapiens_hsa043700.62377717
70HIF-1 signaling pathway_Homo sapiens_hsa040660.62336554
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61502755
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60998487
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57951374
74ErbB signaling pathway_Homo sapiens_hsa040120.57616673
75Shigellosis_Homo sapiens_hsa051310.57387227
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56502194
77Prostate cancer_Homo sapiens_hsa052150.55713121
78Endometrial cancer_Homo sapiens_hsa052130.54976657
79Vibrio cholerae infection_Homo sapiens_hsa051100.54855835
80Pancreatic cancer_Homo sapiens_hsa052120.54403290
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.53923100
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53204742
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.52920814
84Hepatitis B_Homo sapiens_hsa051610.52196881
85Tight junction_Homo sapiens_hsa045300.51197178
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51035726
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49479899
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49343670
89Parkinsons disease_Homo sapiens_hsa050120.49199304
90Pathways in cancer_Homo sapiens_hsa052000.48475231
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46569988
92Renal cell carcinoma_Homo sapiens_hsa052110.45968688
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45889043
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45096317
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44796019
96Proteoglycans in cancer_Homo sapiens_hsa052050.44526151
97Legionellosis_Homo sapiens_hsa051340.44355470
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44337879
99Melanoma_Homo sapiens_hsa052180.43553278
100Dorso-ventral axis formation_Homo sapiens_hsa043200.42009199
101Wnt signaling pathway_Homo sapiens_hsa043100.40285762
102Fructose and mannose metabolism_Homo sapiens_hsa000510.38586486
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38152524
104AMPK signaling pathway_Homo sapiens_hsa041520.37906332
105Carbon metabolism_Homo sapiens_hsa012000.36460675
106Lysine degradation_Homo sapiens_hsa003100.36367860
107Glioma_Homo sapiens_hsa052140.33934846
108B cell receptor signaling pathway_Homo sapiens_hsa046620.33706498
109Glutathione metabolism_Homo sapiens_hsa004800.33684884
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33358911
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.33002565
112FoxO signaling pathway_Homo sapiens_hsa040680.30912466
113Viral myocarditis_Homo sapiens_hsa054160.29796133
114Glucagon signaling pathway_Homo sapiens_hsa049220.28599916
115Influenza A_Homo sapiens_hsa051640.28235245
116Focal adhesion_Homo sapiens_hsa045100.25799313
117Insulin signaling pathway_Homo sapiens_hsa049100.25083029
118Measles_Homo sapiens_hsa051620.23920822
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22506853
120Estrogen signaling pathway_Homo sapiens_hsa049150.21245808

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