UBE2SP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.18012450
2mitotic chromosome condensation (GO:0007076)6.00758044
3mitotic sister chromatid segregation (GO:0000070)5.19885243
4protein localization to chromosome, centromeric region (GO:0071459)5.04128545
5sister chromatid segregation (GO:0000819)4.72179233
6heterochromatin organization (GO:0070828)4.67882579
7DNA strand elongation involved in DNA replication (GO:0006271)4.54533809
8mitotic metaphase plate congression (GO:0007080)4.49645745
9nuclear pore complex assembly (GO:0051292)4.47612764
10regulation of translational termination (GO:0006449)4.46834662
11DNA strand elongation (GO:0022616)4.42851676
12viral mRNA export from host cell nucleus (GO:0046784)4.25706268
13protein localization to kinetochore (GO:0034501)4.19925968
14establishment of integrated proviral latency (GO:0075713)4.07693253
15DNA replication initiation (GO:0006270)4.01245400
16ribosomal small subunit biogenesis (GO:0042274)4.00848131
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.99148038
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.95498997
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.91437168
20formation of translation preinitiation complex (GO:0001731)3.91304883
21chromatin assembly (GO:0031497)3.90102166
22nuclear pore organization (GO:0006999)3.87055213
23spliceosomal tri-snRNP complex assembly (GO:0000244)3.74984098
24telomere maintenance via semi-conservative replication (GO:0032201)3.74176948
25chromosome condensation (GO:0030261)3.72788569
26mitotic nuclear envelope reassembly (GO:0007084)3.67948990
27nuclear envelope reassembly (GO:0031468)3.67948990
28peptidyl-arginine omega-N-methylation (GO:0035247)3.61829952
29ribosome assembly (GO:0042255)3.58228934
30ribosome biogenesis (GO:0042254)3.52892442
31metaphase plate congression (GO:0051310)3.49172961
32mitotic sister chromatid cohesion (GO:0007064)3.47817910
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45698857
34mitotic nuclear envelope disassembly (GO:0007077)3.41086806
35pore complex assembly (GO:0046931)3.39329767
36positive regulation of chromosome segregation (GO:0051984)3.37124450
37maturation of SSU-rRNA (GO:0030490)3.35988793
38ribonucleoprotein complex biogenesis (GO:0022613)3.34096708
39establishment of chromosome localization (GO:0051303)3.32869416
40establishment of viral latency (GO:0019043)3.32285400
41nucleosome disassembly (GO:0006337)3.30604259
42protein-DNA complex disassembly (GO:0032986)3.30604259
43proline biosynthetic process (GO:0006561)3.28209780
44nucleobase-containing small molecule interconversion (GO:0015949)3.23743407
45negative regulation of mRNA processing (GO:0050686)3.23523459
46nuclear envelope disassembly (GO:0051081)3.23265065
47membrane disassembly (GO:0030397)3.23265065
48regulation of translational fidelity (GO:0006450)3.22686745
49DNA replication-dependent nucleosome organization (GO:0034723)3.19658548
50DNA replication-dependent nucleosome assembly (GO:0006335)3.19658548
51negative regulation of RNA splicing (GO:0033119)3.15798065
52DNA packaging (GO:0006323)3.15723055
53chromatin assembly or disassembly (GO:0006333)3.15687462
54Golgi transport vesicle coating (GO:0048200)3.15456548
55COPI coating of Golgi vesicle (GO:0048205)3.15456548
56telomere maintenance via recombination (GO:0000722)3.06474726
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06257955
58regulation of mitotic spindle organization (GO:0060236)3.02692980
59pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.02074131
60regulation of spindle organization (GO:0090224)3.02064076
61rRNA transcription (GO:0009303)3.01844274
62regulation of sister chromatid cohesion (GO:0007063)3.01359412
63negative regulation of mRNA metabolic process (GO:1903312)3.00513145
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.00466210
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00466210
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00466210
67protein localization to chromosome (GO:0034502)3.00123120
68mitotic recombination (GO:0006312)2.96098110
69peptidyl-arginine N-methylation (GO:0035246)2.96040428
70peptidyl-arginine methylation (GO:0018216)2.96040428
71histone arginine methylation (GO:0034969)2.93457256
72protein maturation by protein folding (GO:0022417)2.91434979
73chromosome segregation (GO:0007059)2.91198893
74regulation of chromosome segregation (GO:0051983)2.89626411
75DNA replication checkpoint (GO:0000076)2.87100240
76positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.85506816
77regulation of RNA export from nucleus (GO:0046831)2.85476052
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.84349283
79DNA duplex unwinding (GO:0032508)2.84162901
80trophoblast giant cell differentiation (GO:0060707)2.82263278
81positive regulation of DNA-dependent DNA replication (GO:2000105)2.81359998
82DNA conformation change (GO:0071103)2.81155510
83pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.80201241
84nuclear envelope organization (GO:0006998)2.78668097
85UTP biosynthetic process (GO:0006228)2.78293207
86DNA topological change (GO:0006265)2.77009724
87positive regulation of DNA-templated transcription, elongation (GO:0032786)2.74450305
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.73304759
89folic acid-containing compound biosynthetic process (GO:0009396)2.73260318
90guanosine-containing compound biosynthetic process (GO:1901070)2.72318785
91protein complex localization (GO:0031503)2.71942729
92ribosomal small subunit assembly (GO:0000028)2.67994520
93DNA geometric change (GO:0032392)2.66109300
94glucocorticoid receptor signaling pathway (GO:0042921)2.65645648
95folic acid metabolic process (GO:0046655)2.63566673
96transcription from mitochondrial promoter (GO:0006390)2.62534817
97base-excision repair (GO:0006284)2.61140931
98mitochondrial fusion (GO:0008053)2.59896354
99rRNA processing (GO:0006364)2.57934130
100kinetochore organization (GO:0051383)2.57822450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57463937
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.57145383
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61298464
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41787204
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23216835
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19545845
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85172779
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78500364
9MYC_22102868_ChIP-Seq_BL_Human2.57766222
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48334295
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38809059
12XRN2_22483619_ChIP-Seq_HELA_Human2.30644243
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29917979
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29049015
15VDR_21846776_ChIP-Seq_THP-1_Human2.15619324
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13686159
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10178598
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08264064
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08205895
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.07104403
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.03123323
22AR_21909140_ChIP-Seq_LNCAP_Human2.02585542
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00480796
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90864538
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.86537781
26ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79611897
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.78375818
28DCP1A_22483619_ChIP-Seq_HELA_Human1.77365670
29CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.72566504
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69038936
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67732075
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65744099
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65062555
34TTF2_22483619_ChIP-Seq_HELA_Human1.64188055
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63341470
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62443793
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60930519
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.59308195
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57334530
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55981109
41GABP_19822575_ChIP-Seq_HepG2_Human1.55298498
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53565646
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49844662
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46314345
45CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.45508708
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.44139173
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43633606
48CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43382115
49ZNF263_19887448_ChIP-Seq_K562_Human1.43295648
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43012176
51CIITA_25753668_ChIP-Seq_RAJI_Human1.40992972
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38154303
53KDM5A_27292631_Chip-Seq_BREAST_Human1.33518301
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33410041
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32934697
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27718724
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26820684
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26482174
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.26131208
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25298967
61LXR_22292898_ChIP-Seq_THP-1_Human1.24445421
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24105666
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20029415
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19602676
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.15945329
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15287158
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14687058
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.14292485
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13123183
70FOXP3_21729870_ChIP-Seq_TREG_Human1.12538838
71RACK7_27058665_Chip-Seq_MCF-7_Human1.11868425
72TFEB_21752829_ChIP-Seq_HELA_Human1.10934713
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10405976
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09019939
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07345819
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07087514
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07023751
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07002030
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06270320
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05276605
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03560423
82ATF3_27146783_Chip-Seq_COLON_Human1.03557583
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01934883
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01776493
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01425285
86MAF_26560356_Chip-Seq_TH1_Human1.00082624
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00047761
88GABP_17652178_ChIP-ChIP_JURKAT_Human0.99768131
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99522183
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98744881
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98110152
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96988393
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96833588
94P68_20966046_ChIP-Seq_HELA_Human0.95831000
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95757306
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95198218
97VDR_23849224_ChIP-Seq_CD4+_Human0.93126584
98MAF_26560356_Chip-Seq_TH2_Human0.92080082
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91678577
100TCF7_22412390_ChIP-Seq_EML_Mouse0.91614784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.39231580
2MP0003693_abnormal_embryo_hatching4.25292396
3MP0010094_abnormal_chromosome_stability3.92677600
4MP0002877_abnormal_melanocyte_morpholog3.58375605
5MP0003077_abnormal_cell_cycle3.49372335
6MP0004957_abnormal_blastocyst_morpholog3.49134307
7MP0005623_abnormal_meninges_morphology2.95542391
8MP0005451_abnormal_body_composition2.64611115
9MP0004185_abnormal_adipocyte_glucose2.63787552
10MP0008932_abnormal_embryonic_tissue2.60741707
11MP0008007_abnormal_cellular_replicative2.55716157
12MP0001730_embryonic_growth_arrest2.47844163
13MP0003705_abnormal_hypodermis_morpholog2.40696655
14MP0000350_abnormal_cell_proliferation2.32607136
15MP0008057_abnormal_DNA_replication2.29772473
16MP0008058_abnormal_DNA_repair2.06760596
17MP0010352_gastrointestinal_tract_polyps2.03208840
18MP0004233_abnormal_muscle_weight1.99912892
19MP0005076_abnormal_cell_differentiation1.90914473
20MP0000537_abnormal_urethra_morphology1.75006599
21MP0010307_abnormal_tumor_latency1.69981174
22MP0001672_abnormal_embryogenesis/_devel1.68672423
23MP0005380_embryogenesis_phenotype1.68672423
24MP0003786_premature_aging1.67914599
25MP0002080_prenatal_lethality1.66241416
26MP0001188_hyperpigmentation1.60847773
27MP0000313_abnormal_cell_death1.56475673
28MP0005501_abnormal_skin_physiology1.53940017
29MP0003984_embryonic_growth_retardation1.51244731
30MP0002396_abnormal_hematopoietic_system1.50909412
31MP0009333_abnormal_splenocyte_physiolog1.49320523
32MP0001697_abnormal_embryo_size1.47707301
33MP0003566_abnormal_cell_adhesion1.46917980
34MP0001661_extended_life_span1.43388123
35MP0000490_abnormal_crypts_of1.42327974
36MP0002088_abnormal_embryonic_growth/wei1.40804346
37MP0010030_abnormal_orbit_morphology1.40069975
38MP0002085_abnormal_embryonic_tissue1.39651132
39MP0009053_abnormal_anal_canal1.30962388
40MP0000858_altered_metastatic_potential1.28697637
41MP0001849_ear_inflammation1.28520444
42MP0009672_abnormal_birth_weight1.27106819
43MP0000733_abnormal_muscle_development1.26738934
44MP0002086_abnormal_extraembryonic_tissu1.22460756
45MP0003453_abnormal_keratinocyte_physiol1.20584805
46MP0003315_abnormal_perineum_morphology1.20145075
47MP0004808_abnormal_hematopoietic_stem1.18620288
48MP0002084_abnormal_developmental_patter1.16753067
49MP0004197_abnormal_fetal_growth/weight/1.13948588
50MP0002019_abnormal_tumor_incidence1.13753468
51MP0002796_impaired_skin_barrier1.12665326
52MP0001348_abnormal_lacrimal_gland1.11013278
53MP0009697_abnormal_copulation1.09915857
54MP0010234_abnormal_vibrissa_follicle1.09514185
55MP0000678_abnormal_parathyroid_gland1.08599359
56MP0009379_abnormal_foot_pigmentation1.08284991
57MP0001727_abnormal_embryo_implantation1.08259773
58MP0001346_abnormal_lacrimal_gland1.05049882
59MP0000703_abnormal_thymus_morphology1.04629582
60MP0005621_abnormal_cell_physiology1.03082487
61MP0005666_abnormal_adipose_tissue1.01651101
62MP0008438_abnormal_cutaneous_collagen1.01630887
63MP0001915_intracranial_hemorrhage0.99551364
64MP0009278_abnormal_bone_marrow0.99130396
65MP0003763_abnormal_thymus_physiology0.97670434
66MP0002089_abnormal_postnatal_growth/wei0.97312462
67MP0003950_abnormal_plasma_membrane0.95524855
68MP0000358_abnormal_cell_content/0.94271935
69MP0000003_abnormal_adipose_tissue0.90779016
70MP0000750_abnormal_muscle_regeneration0.89976027
71MP0005384_cellular_phenotype0.89554633
72MP0002249_abnormal_larynx_morphology0.88939215
73MP0002060_abnormal_skin_morphology0.85100409
74MP0002092_abnormal_eye_morphology0.81070867
75MP0003091_abnormal_cell_migration0.80538821
76MP0005257_abnormal_intraocular_pressure0.80371364
77MP0005023_abnormal_wound_healing0.79714869
78MP0002697_abnormal_eye_size0.79660248
79MP0001216_abnormal_epidermal_layer0.79497921
80MP0002163_abnormal_gland_morphology0.79234421
81MP0001853_heart_inflammation0.78927745
82MP0003942_abnormal_urinary_system0.78793422
83MP0005375_adipose_tissue_phenotype0.78271372
84MP0003115_abnormal_respiratory_system0.75665543
85MP0000534_abnormal_ureter_morphology0.73239730
86MP0002111_abnormal_tail_morphology0.72509046
87MP0002006_tumorigenesis0.71826477
88MP0005058_abnormal_lysosome_morphology0.69989014
89MP0002970_abnormal_white_adipose0.69643155
90MP0000759_abnormal_skeletal_muscle0.67119092
91MP0000428_abnormal_craniofacial_morphol0.66095706
92MP0002114_abnormal_axial_skeleton0.66024331
93MP0002398_abnormal_bone_marrow0.65285992
94MP0002722_abnormal_immune_system0.64466368
95MP0003221_abnormal_cardiomyocyte_apopto0.64190283
96MP0000747_muscle_weakness0.63695402
97MP0000049_abnormal_middle_ear0.63556947
98MP0009250_abnormal_appendicular_skeleto0.62509081
99MP0003937_abnormal_limbs/digits/tail_de0.62041665
100MP0001243_abnormal_dermal_layer0.61270361

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the sacrum (HP:0008517)3.64172482
2Hyperacusis (HP:0010780)3.27897463
3Long palpebral fissure (HP:0000637)3.23772486
4Broad distal phalanx of finger (HP:0009836)3.13060311
5Ulnar bowing (HP:0003031)3.07128652
6Progressive muscle weakness (HP:0003323)3.05261733
7Achilles tendon contracture (HP:0001771)2.83700681
8Trismus (HP:0000211)2.77954408
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75255347
10Breast hypoplasia (HP:0003187)2.73872171
11Squamous cell carcinoma (HP:0002860)2.73784165
12Deep palmar crease (HP:0006191)2.68976307
13Proximal placement of thumb (HP:0009623)2.65774129
14Entropion (HP:0000621)2.63754953
15Rough bone trabeculation (HP:0100670)2.61555130
16Deviation of the thumb (HP:0009603)2.60973594
17Abnormality of the umbilical cord (HP:0010881)2.55533110
18Abnormality of the fetal cardiovascular system (HP:0010948)2.52540005
19Abnormal umbilical cord blood vessels (HP:0011403)2.52540005
20Single umbilical artery (HP:0001195)2.52540005
21Abnormality of the Achilles tendon (HP:0005109)2.50600544
22Septate vagina (HP:0001153)2.49292564
23Insomnia (HP:0100785)2.49020329
24Abnormality of the distal phalanges of the toes (HP:0010182)2.44374027
25Premature rupture of membranes (HP:0001788)2.44292281
26Increased nuchal translucency (HP:0010880)2.43510535
27Microvesicular hepatic steatosis (HP:0001414)2.35328083
28Selective tooth agenesis (HP:0001592)2.30169147
29Chromsome breakage (HP:0040012)2.25782655
30High anterior hairline (HP:0009890)2.20981056
31Poikiloderma (HP:0001029)2.17070868
32Abnormality of cells of the erythroid lineage (HP:0012130)2.15202304
33Overlapping toe (HP:0001845)2.15180131
34Reticulocytopenia (HP:0001896)2.13777106
35Back pain (HP:0003418)2.12458438
36Abnormality of the phalanges of the hallux (HP:0010057)2.06689724
37Multiple enchondromatosis (HP:0005701)2.04321780
38Abnormal trabecular bone morphology (HP:0100671)2.02589569
39Broad face (HP:0000283)1.99219371
40Microretrognathia (HP:0000308)1.97525087
41Elbow flexion contracture (HP:0002987)1.96562320
42Ureteral duplication (HP:0000073)1.94342060
43Atresia of the external auditory canal (HP:0000413)1.92408012
44Increased connective tissue (HP:0009025)1.90751884
45Short nail (HP:0001799)1.90280315
46Long eyelashes (HP:0000527)1.90027444
47Abnormal number of erythroid precursors (HP:0012131)1.88803728
48Ragged-red muscle fibers (HP:0003200)1.87052016
49Bowed forearm bones (HP:0003956)1.85398781
50Bowing of the arm (HP:0006488)1.85398781
51Distal lower limb amyotrophy (HP:0008944)1.85381433
52Abnormal number of incisors (HP:0011064)1.84030354
53Patellar dislocation (HP:0002999)1.82864871
54Reduced subcutaneous adipose tissue (HP:0003758)1.82458828
55Birth length less than 3rd percentile (HP:0003561)1.80499364
56Unilateral renal agenesis (HP:0000122)1.80489763
57Osteolytic defects of the phalanges of the hand (HP:0009771)1.77327164
58Osteolytic defects of the hand bones (HP:0009699)1.77327164
59Vertebral compression fractures (HP:0002953)1.74927087
60Hyperparathyroidism (HP:0000843)1.74732830
61Orthostatic hypotension (HP:0001278)1.73133204
62Renal duplication (HP:0000075)1.72579264
63Horseshoe kidney (HP:0000085)1.71912716
64Overriding aorta (HP:0002623)1.68731553
65Glossoptosis (HP:0000162)1.65874352
66Cutaneous melanoma (HP:0012056)1.65518245
67Self-mutilation (HP:0000742)1.65312786
68Cortical dysplasia (HP:0002539)1.64423054
69Short clavicles (HP:0000894)1.64145910
70Abnormality of chromosome segregation (HP:0002916)1.63814903
71Nonimmune hydrops fetalis (HP:0001790)1.63153666
72Acute lymphatic leukemia (HP:0006721)1.63124563
73Secondary amenorrhea (HP:0000869)1.62586007
74Aplastic anemia (HP:0001915)1.62405166
75Disproportionate tall stature (HP:0001519)1.62228661
76Flared metaphyses (HP:0003015)1.62175491
77Spastic diplegia (HP:0001264)1.61449718
78Hypergonadotropic hypogonadism (HP:0000815)1.59664177
79Insulin resistance (HP:0000855)1.59496479
80Abnormality of carpal bone ossification (HP:0006257)1.59271239
81Pseudobulbar signs (HP:0002200)1.59147549
82Syringomyelia (HP:0003396)1.59013070
83Spinal cord lesions (HP:0100561)1.59013070
84Dislocated radial head (HP:0003083)1.58543019
85Aplasia/Hypoplasia of the patella (HP:0006498)1.58057755
86Aplasia/Hypoplasia of the clavicles (HP:0006710)1.57350308
87Urethral obstruction (HP:0000796)1.57223308
88Hypertensive crisis (HP:0100735)1.57019073
89Abnormal foot bone ossification (HP:0010675)1.55976047
90Renal cell carcinoma (HP:0005584)1.55595222
91Duplication of thumb phalanx (HP:0009942)1.55122327
92Sparse lateral eyebrow (HP:0005338)1.53865572
93Multiple lipomas (HP:0001012)1.53782711
94Leiomyosarcoma (HP:0100243)1.53353918
95Uterine leiomyosarcoma (HP:0002891)1.53353918
96Abnormality of the distal phalanx of the thumb (HP:0009617)1.53273448
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53139421
98Cafe-au-lait spot (HP:0000957)1.53007776
99Abnormal ossification of hand bones (HP:0005921)1.52387246
100Flattened epiphyses (HP:0003071)1.51666842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.22056457
2BUB14.08842421
3TRIB33.57510027
4NME23.39550720
5IRAK33.36451641
6CDK122.86637306
7VRK22.79600258
8CDC72.77732190
9EEF2K2.57939234
10TESK22.11323561
11ICK2.10006537
12BRAF1.96709403
13TAF11.72205106
14MAP3K101.71031098
15AURKA1.70428708
16TTK1.70275975
17VRK11.60887154
18CHEK21.54484248
19NEK11.54137030
20PRPF4B1.50764180
21PAK41.49033813
22MAP3K81.47555444
23CDK81.43490501
24CDK71.36221852
25ARAF1.33253700
26AURKB1.31816732
27BRSK11.29804515
28CDK41.29774996
29STK101.29111126
30STK41.29005843
31TLK11.28136289
32SIK11.27368810
33SRPK11.24065024
34PBK1.22671425
35ZAK1.20590620
36RPS6KB21.17671093
37WEE11.17573217
38NEK21.16001620
39TESK11.13614096
40TSSK61.13250397
41ILK1.11968910
42TAOK21.07479084
43PLK11.02344758
44CHEK11.02083381
45ATR0.99287642
46EPHA20.96825792
47KDR0.91752498
48TTN0.91039880
49CDK90.90783867
50PLK40.89903611
51MST1R0.87921667
52ERN10.86664638
53CAMK1D0.85250418
54LATS20.84790135
55SCYL20.77311517
56MTOR0.73309211
57IRAK40.73098295
58AKT20.71939484
59PAK10.70113939
60DAPK30.69743223
61LIMK10.68868642
62STK160.68412931
63MAP3K90.68338077
64IRAK20.66959299
65PLK30.62993261
66PTK20.62047583
67CAMK1G0.61407848
68MOS0.58918958
69MAPK110.56245235
70MAP2K30.55630106
71EIF2AK10.55209241
72CDK60.54702957
73BRD40.53844799
74PRKD30.52464413
75CDK10.51363216
76CDK11A0.50535893
77RPS6KA40.50230659
78CDK20.50188970
79MELK0.50009133
80SIK30.49908439
81ERBB40.44789637
82LRRK20.44416535
83CDK150.44190308
84RPS6KA50.41140825
85PIM20.40716376
86ATM0.40549931
87CDK180.40487833
88PRKCI0.40327774
89PTK60.39896412
90PAK20.39869070
91BRSK20.39866626
92MAP2K20.37615137
93CDK140.37221542
94SIK20.36009572
95PASK0.35906289
96DMPK0.35421308
97PKN20.35022950
98MAP3K110.33933121
99PDGFRA0.33016873
100MAP3K130.32194932

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.68660054
2Base excision repair_Homo sapiens_hsa034102.92583051
3Cell cycle_Homo sapiens_hsa041102.82221625
4Mismatch repair_Homo sapiens_hsa034302.66506027
5Spliceosome_Homo sapiens_hsa030402.61797812
6Sulfur relay system_Homo sapiens_hsa041222.59300697
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55865123
8Systemic lupus erythematosus_Homo sapiens_hsa053222.44077604
9Nucleotide excision repair_Homo sapiens_hsa034202.17069484
10RNA transport_Homo sapiens_hsa030132.15558614
11Ribosome_Homo sapiens_hsa030102.13863298
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12408277
13Bladder cancer_Homo sapiens_hsa052192.06852236
14Pyrimidine metabolism_Homo sapiens_hsa002402.01161340
15Alcoholism_Homo sapiens_hsa050341.79252056
16Viral carcinogenesis_Homo sapiens_hsa052031.76438467
17Biosynthesis of amino acids_Homo sapiens_hsa012301.74764451
18One carbon pool by folate_Homo sapiens_hsa006701.68242444
19mRNA surveillance pathway_Homo sapiens_hsa030151.66458323
20Chronic myeloid leukemia_Homo sapiens_hsa052201.56856409
21Thyroid cancer_Homo sapiens_hsa052161.52069393
22Homologous recombination_Homo sapiens_hsa034401.49243135
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48119873
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47351232
25Pentose phosphate pathway_Homo sapiens_hsa000301.46187006
26Proteasome_Homo sapiens_hsa030501.44632682
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41924528
28RNA polymerase_Homo sapiens_hsa030201.40850657
29Pancreatic cancer_Homo sapiens_hsa052121.32649036
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.32019224
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28388464
32Non-homologous end-joining_Homo sapiens_hsa034501.25821765
33Non-small cell lung cancer_Homo sapiens_hsa052231.25358239
34p53 signaling pathway_Homo sapiens_hsa041151.13279197
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10238343
36Fanconi anemia pathway_Homo sapiens_hsa034601.07045687
37Epstein-Barr virus infection_Homo sapiens_hsa051691.06234128
38HTLV-I infection_Homo sapiens_hsa051661.02040334
39Carbon metabolism_Homo sapiens_hsa012000.99899373
40Vitamin B6 metabolism_Homo sapiens_hsa007500.97451505
41Shigellosis_Homo sapiens_hsa051310.93812201
42MicroRNAs in cancer_Homo sapiens_hsa052060.92479257
43Small cell lung cancer_Homo sapiens_hsa052220.91988615
44Colorectal cancer_Homo sapiens_hsa052100.91729423
45Apoptosis_Homo sapiens_hsa042100.89311177
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88851939
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87956630
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.87196013
49Acute myeloid leukemia_Homo sapiens_hsa052210.86642140
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85850510
51Basal transcription factors_Homo sapiens_hsa030220.80947301
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78951572
53Fructose and mannose metabolism_Homo sapiens_hsa000510.75803123
54N-Glycan biosynthesis_Homo sapiens_hsa005100.75328020
55Prostate cancer_Homo sapiens_hsa052150.74375507
56Folate biosynthesis_Homo sapiens_hsa007900.73605077
57Hepatitis B_Homo sapiens_hsa051610.73488250
58Glioma_Homo sapiens_hsa052140.72786412
59Herpes simplex infection_Homo sapiens_hsa051680.71989062
60Purine metabolism_Homo sapiens_hsa002300.71247732
61Endometrial cancer_Homo sapiens_hsa052130.71105325
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70489839
63Prion diseases_Homo sapiens_hsa050200.69940147
64Oocyte meiosis_Homo sapiens_hsa041140.69169734
65Melanoma_Homo sapiens_hsa052180.67920401
66Galactose metabolism_Homo sapiens_hsa000520.62974432
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61194768
68Salmonella infection_Homo sapiens_hsa051320.60926680
69Adherens junction_Homo sapiens_hsa045200.60001221
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.57784929
71Hippo signaling pathway_Homo sapiens_hsa043900.56970384
72Notch signaling pathway_Homo sapiens_hsa043300.56843043
73Lysine degradation_Homo sapiens_hsa003100.56081209
74Selenocompound metabolism_Homo sapiens_hsa004500.54266569
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53519022
76RNA degradation_Homo sapiens_hsa030180.52980714
77Basal cell carcinoma_Homo sapiens_hsa052170.49908163
78Renal cell carcinoma_Homo sapiens_hsa052110.49030851
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48617560
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47613696
81Vibrio cholerae infection_Homo sapiens_hsa051100.47441224
82Proteoglycans in cancer_Homo sapiens_hsa052050.45878577
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44933892
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.44929464
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44756541
86Sulfur metabolism_Homo sapiens_hsa009200.43305844
87B cell receptor signaling pathway_Homo sapiens_hsa046620.42377692
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42086446
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.41324678
90Influenza A_Homo sapiens_hsa051640.40486390
91Pyruvate metabolism_Homo sapiens_hsa006200.37529785
92mTOR signaling pathway_Homo sapiens_hsa041500.36995810
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34785556
94VEGF signaling pathway_Homo sapiens_hsa043700.34777187
95Fatty acid elongation_Homo sapiens_hsa000620.34763204
96Viral myocarditis_Homo sapiens_hsa054160.33956658
97AMPK signaling pathway_Homo sapiens_hsa041520.32834665
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32102153
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32001679
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31606211

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