UBE2SP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.61258717
2mitotic chromosome condensation (GO:0007076)5.31363450
3regulation of translational termination (GO:0006449)5.13962638
4mitotic sister chromatid segregation (GO:0000070)4.58759276
5peptidyl-arginine omega-N-methylation (GO:0035247)4.46404516
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.42252418
7mitotic metaphase plate congression (GO:0007080)4.37319771
8protein localization to chromosome, centromeric region (GO:0071459)4.24770991
9mitotic nuclear envelope reassembly (GO:0007084)4.16543865
10nuclear envelope reassembly (GO:0031468)4.16543865
11sister chromatid segregation (GO:0000819)4.11441839
12protein maturation by protein folding (GO:0022417)4.08138608
13spliceosomal tri-snRNP complex assembly (GO:0000244)4.03171466
14Golgi transport vesicle coating (GO:0048200)3.99718756
15COPI coating of Golgi vesicle (GO:0048205)3.99718756
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.98045952
17DNA strand elongation involved in DNA replication (GO:0006271)3.97290282
18establishment of integrated proviral latency (GO:0075713)3.93260199
19DNA strand elongation (GO:0022616)3.87282371
20heterochromatin organization (GO:0070828)3.85646168
21histone arginine methylation (GO:0034969)3.82121450
22establishment of viral latency (GO:0019043)3.73996478
23peptidyl-arginine methylation (GO:0018216)3.72790031
24peptidyl-arginine N-methylation (GO:0035246)3.72790031
25formation of translation preinitiation complex (GO:0001731)3.72464591
26ribosome biogenesis (GO:0042254)3.67804027
27mitochondrial fusion (GO:0008053)3.58001356
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.54803490
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.54472140
30nuclear pore complex assembly (GO:0051292)3.53980122
31DNA replication initiation (GO:0006270)3.46433645
32ribosome assembly (GO:0042255)3.45800373
33chaperone mediated protein folding requiring cofactor (GO:0051085)3.45480089
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42172219
35viral mRNA export from host cell nucleus (GO:0046784)3.41209917
36protein localization to kinetochore (GO:0034501)3.38302291
37metaphase plate congression (GO:0051310)3.36477495
38de novo posttranslational protein folding (GO:0051084)3.34657457
39telomere maintenance via semi-conservative replication (GO:0032201)3.34570018
40de novo protein folding (GO:0006458)3.32474091
41regulation of translational fidelity (GO:0006450)3.31105784
42positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.24359069
43negative regulation of mRNA processing (GO:0050686)3.23908123
44positive regulation of chromosome segregation (GO:0051984)3.21346057
45ribonucleoprotein complex biogenesis (GO:0022613)3.16794798
46establishment of chromosome localization (GO:0051303)3.16175501
47chromosome condensation (GO:0030261)3.14802285
48pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14631355
49nuclear pore organization (GO:0006999)3.13700178
50chromatin assembly (GO:0031497)3.13220589
51mitotic nuclear envelope disassembly (GO:0007077)3.10054704
52protein complex localization (GO:0031503)3.07444493
53proline biosynthetic process (GO:0006561)3.05148031
54UTP biosynthetic process (GO:0006228)3.02312227
55nucleobase-containing small molecule interconversion (GO:0015949)3.00096851
56pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.98055946
57pore complex assembly (GO:0046931)2.95535668
58negative regulation of mRNA metabolic process (GO:1903312)2.94586691
59nuclear envelope disassembly (GO:0051081)2.94284359
60membrane disassembly (GO:0030397)2.94284359
61ribosomal small subunit biogenesis (GO:0042274)2.91908906
62negative regulation of RNA splicing (GO:0033119)2.91262047
63guanosine-containing compound biosynthetic process (GO:1901070)2.90779310
64regulation of spindle organization (GO:0090224)2.88875304
65regulation of mitotic spindle organization (GO:0060236)2.86745206
66pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84817815
67tRNA methylation (GO:0030488)2.84070919
68rRNA transcription (GO:0009303)2.83130674
69protein localization to chromosome (GO:0034502)2.81721975
70regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.81365015
71folic acid-containing compound biosynthetic process (GO:0009396)2.79809138
72natural killer cell mediated cytotoxicity (GO:0042267)2.78639273
73natural killer cell mediated immunity (GO:0002228)2.78639273
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73856650
75nucleosome disassembly (GO:0006337)2.73114555
76protein-DNA complex disassembly (GO:0032986)2.73114555
77cellular protein complex localization (GO:0034629)2.70923785
78maturation of SSU-rRNA (GO:0030490)2.69134125
79DNA packaging (GO:0006323)2.68334106
80L-serine metabolic process (GO:0006563)2.68000279
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.66544821
82positive regulation of DNA-templated transcription, elongation (GO:0032786)2.66488215
83nuclear envelope organization (GO:0006998)2.66401816
84pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.64574148
85spliceosomal snRNP assembly (GO:0000387)2.63974441
86positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.63628425
87regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.63628425
88protein localization to endosome (GO:0036010)2.63182311
89mitotic sister chromatid cohesion (GO:0007064)2.62830411
90regulation of chromosome segregation (GO:0051983)2.61792337
913-UTR-mediated mRNA stabilization (GO:0070935)2.60126855
92protein K6-linked ubiquitination (GO:0085020)2.59560545
93trophoblast giant cell differentiation (GO:0060707)2.58778293
94telomere maintenance via recombination (GO:0000722)2.58542731
95CTP biosynthetic process (GO:0006241)2.57158618
96CTP metabolic process (GO:0046036)2.57158618
97UTP metabolic process (GO:0046051)2.56568624
98regulation of protein heterodimerization activity (GO:0043497)2.56523199
99regulation of translational elongation (GO:0006448)2.56196173
100chromatin assembly or disassembly (GO:0006333)2.53962155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60063882
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.29714262
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69733777
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.53836875
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28791842
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.02467612
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.02178195
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97583220
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55650564
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43997343
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43136656
12XRN2_22483619_ChIP-Seq_HELA_Human2.39549163
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35099507
14MYC_22102868_ChIP-Seq_BL_Human2.35089493
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31899981
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.27324133
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24690039
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23875840
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23207271
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.20974821
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18995703
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.17996583
23CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.12286080
24DCP1A_22483619_ChIP-Seq_HELA_Human2.05350133
25VDR_21846776_ChIP-Seq_THP-1_Human2.02434763
26ZFX_18555785_ChIP-Seq_MESCs_Mouse1.96812295
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.91997359
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86781780
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85872673
30GABP_19822575_ChIP-Seq_HepG2_Human1.85736106
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83256198
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81460569
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81050494
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80602262
35TTF2_22483619_ChIP-Seq_HELA_Human1.72062732
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.60221765
37ZNF263_19887448_ChIP-Seq_K562_Human1.59744426
38CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.58153879
39AR_21909140_ChIP-Seq_LNCAP_Human1.56300736
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55912363
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55629498
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53511672
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52766059
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.52043262
45CIITA_25753668_ChIP-Seq_RAJI_Human1.50611291
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.47557544
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45000129
48CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.44952878
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43863535
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40871879
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35988643
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35123513
53KDM5A_27292631_Chip-Seq_BREAST_Human1.34547538
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34390344
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34240775
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32700186
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32159722
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31080366
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28377469
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25498026
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25421455
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.25355832
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.25141050
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24799677
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.23068039
66TFEB_21752829_ChIP-Seq_HELA_Human1.22791572
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22042606
68LXR_22292898_ChIP-Seq_THP-1_Human1.21883486
69FOXP3_21729870_ChIP-Seq_TREG_Human1.19662888
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17936061
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17802676
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16679445
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14839581
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14447549
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14118362
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13862410
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12390939
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12082497
79RACK7_27058665_Chip-Seq_MCF-7_Human1.10549086
80ATF3_27146783_Chip-Seq_COLON_Human1.10219936
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09158295
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06335700
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06158669
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05738885
85VDR_23849224_ChIP-Seq_CD4+_Human1.05623675
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00570874
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00344336
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98447682
89TP53_22127205_ChIP-Seq_IMR90_Human0.96855028
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95633995
91TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94176770
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93737886
93OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93451863
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92250070
95FOXP1_21924763_ChIP-Seq_HESCs_Human0.92165195
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92031512
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91941104
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.91541855
99TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90226302
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89766263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.60300586
2MP0003111_abnormal_nucleus_morphology4.43575239
3MP0010094_abnormal_chromosome_stability3.78915252
4MP0002877_abnormal_melanocyte_morpholog3.64518294
5MP0003077_abnormal_cell_cycle3.33333819
6MP0004957_abnormal_blastocyst_morpholog3.32622361
7MP0005451_abnormal_body_composition3.23436769
8MP0005623_abnormal_meninges_morphology2.86438430
9MP0008932_abnormal_embryonic_tissue2.67804081
10MP0001730_embryonic_growth_arrest2.48030867
11MP0004185_abnormal_adipocyte_glucose2.39165295
12MP0010352_gastrointestinal_tract_polyps2.26504545
13MP0003705_abnormal_hypodermis_morpholog2.26085062
14MP0008007_abnormal_cellular_replicative2.21973497
15MP0000350_abnormal_cell_proliferation2.12986882
16MP0004233_abnormal_muscle_weight2.10306601
17MP0008058_abnormal_DNA_repair1.96978950
18MP0000537_abnormal_urethra_morphology1.86340540
19MP0005076_abnormal_cell_differentiation1.72072799
20MP0002080_prenatal_lethality1.70896612
21MP0010307_abnormal_tumor_latency1.65955304
22MP0000490_abnormal_crypts_of1.64008361
23MP0003566_abnormal_cell_adhesion1.59762166
24MP0001672_abnormal_embryogenesis/_devel1.56122092
25MP0005380_embryogenesis_phenotype1.56122092
26MP0000313_abnormal_cell_death1.52139004
27MP0003221_abnormal_cardiomyocyte_apopto1.50680409
28MP0000358_abnormal_cell_content/1.50280015
29MP0003786_premature_aging1.48672038
30MP0005501_abnormal_skin_physiology1.48658938
31MP0001697_abnormal_embryo_size1.45528769
32MP0001727_abnormal_embryo_implantation1.44122492
33MP0002085_abnormal_embryonic_tissue1.41516131
34MP0003303_peritoneal_inflammation1.37993011
35MP0001348_abnormal_lacrimal_gland1.35705844
36MP0008057_abnormal_DNA_replication1.34490248
37MP0003453_abnormal_keratinocyte_physiol1.34038794
38MP0009333_abnormal_splenocyte_physiolog1.30768688
39MP0003984_embryonic_growth_retardation1.30055457
40MP0009672_abnormal_birth_weight1.29726245
41MP0000858_altered_metastatic_potential1.28299031
42MP0000750_abnormal_muscle_regeneration1.28260628
43MP0002084_abnormal_developmental_patter1.27160455
44MP0005257_abnormal_intraocular_pressure1.26388711
45MP0004197_abnormal_fetal_growth/weight/1.24283057
46MP0002088_abnormal_embryonic_growth/wei1.20842186
47MP0005384_cellular_phenotype1.18435514
48MP0005621_abnormal_cell_physiology1.17478399
49MP0001188_hyperpigmentation1.16339523
50MP0002163_abnormal_gland_morphology1.16172475
51MP0000003_abnormal_adipose_tissue1.15655421
52MP0000678_abnormal_parathyroid_gland1.15258278
53MP0003091_abnormal_cell_migration1.14467266
54MP0000733_abnormal_muscle_development1.14262415
55MP0010030_abnormal_orbit_morphology1.13669816
56MP0008260_abnormal_autophagy1.13123393
57MP0005058_abnormal_lysosome_morphology1.11966590
58MP0003950_abnormal_plasma_membrane1.11330501
59MP0001849_ear_inflammation1.09741786
60MP0006035_abnormal_mitochondrial_morpho1.09647998
61MP0009840_abnormal_foam_cell1.09238739
62MP0002086_abnormal_extraembryonic_tissu1.08066100
63MP0005666_abnormal_adipose_tissue1.05712971
64MP0009278_abnormal_bone_marrow1.05001054
65MP0002796_impaired_skin_barrier1.01994331
66MP0002019_abnormal_tumor_incidence1.00551037
67MP0009053_abnormal_anal_canal1.00541003
68MP0003315_abnormal_perineum_morphology0.96545160
69MP0002089_abnormal_postnatal_growth/wei0.96119025
70MP0004808_abnormal_hematopoietic_stem0.95496996
71MP0010234_abnormal_vibrissa_follicle0.95231219
72MP0005375_adipose_tissue_phenotype0.91520448
73MP0000747_muscle_weakness0.91239904
74MP0001216_abnormal_epidermal_layer0.90095462
75MP0004510_myositis0.85656391
76MP0001346_abnormal_lacrimal_gland0.79540821
77MP0001853_heart_inflammation0.78651308
78MP0002092_abnormal_eye_morphology0.76909149
79MP0002697_abnormal_eye_size0.75456661
80MP0002332_abnormal_exercise_endurance0.74212761
81MP0001661_extended_life_span0.72700884
82MP0000759_abnormal_skeletal_muscle0.70750556
83MP0004782_abnormal_surfactant_physiolog0.69473812
84MP0003115_abnormal_respiratory_system0.69007115
85MP0003718_maternal_effect0.68517137
86MP0003806_abnormal_nucleotide_metabolis0.68257776
87MP0002111_abnormal_tail_morphology0.67862614
88MP0002254_reproductive_system_inflammat0.66994495
89MP0002249_abnormal_larynx_morphology0.66356366
90MP0001243_abnormal_dermal_layer0.65840357
91MP0003448_altered_tumor_morphology0.65242049
92MP0003941_abnormal_skin_development0.65089418
93MP0003123_paternal_imprinting0.63958857
94MP0002060_abnormal_skin_morphology0.62982280
95MP0000703_abnormal_thymus_morphology0.62946890
96MP0003861_abnormal_nervous_system0.62821307
97MP0000049_abnormal_middle_ear0.62503952
98MP0001529_abnormal_vocalization0.62188313
99MP0002210_abnormal_sex_determination0.61942739
100MP0003385_abnormal_body_wall0.60188536

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.83368484
2Aplasia/Hypoplasia of the sacrum (HP:0008517)3.52691979
3Broad distal phalanx of finger (HP:0009836)3.31955659
4Achilles tendon contracture (HP:0001771)3.25612690
5Long palpebral fissure (HP:0000637)3.02922393
6Progressive muscle weakness (HP:0003323)3.01024181
7Insomnia (HP:0100785)2.94842869
8Microretrognathia (HP:0000308)2.93302483
9Shoulder girdle muscle weakness (HP:0003547)2.91141845
10Cortical dysplasia (HP:0002539)2.88094976
11Unilateral renal agenesis (HP:0000122)2.83947658
12Upper limb muscle weakness (HP:0003484)2.82881379
13Rough bone trabeculation (HP:0100670)2.75825670
14Selective tooth agenesis (HP:0001592)2.72976078
15Abnormality of the umbilical cord (HP:0010881)2.72406965
16Pelvic girdle muscle weakness (HP:0003749)2.71500637
17Abnormality of the Achilles tendon (HP:0005109)2.67325566
18Proximal placement of thumb (HP:0009623)2.64153257
19Abnormality of the distal phalanges of the toes (HP:0010182)2.64048758
20Deviation of the thumb (HP:0009603)2.63419201
21Trismus (HP:0000211)2.61924178
22Ulnar bowing (HP:0003031)2.57388084
23Short nail (HP:0001799)2.52041789
24Deep palmar crease (HP:0006191)2.49197340
25Abnormal umbilical cord blood vessels (HP:0011403)2.45993422
26Single umbilical artery (HP:0001195)2.45993422
27Abnormality of the fetal cardiovascular system (HP:0010948)2.45993422
28Multiple enchondromatosis (HP:0005701)2.41829330
29Squamous cell carcinoma (HP:0002860)2.41597611
30Ragged-red muscle fibers (HP:0003200)2.38723276
31Premature rupture of membranes (HP:0001788)2.37711668
32Termporal pattern (HP:0011008)2.34172473
33Insidious onset (HP:0003587)2.34172473
34Abnormality of the anterior horn cell (HP:0006802)2.33834195
35Degeneration of anterior horn cells (HP:0002398)2.33834195
36Entropion (HP:0000621)2.33829465
37Microvesicular hepatic steatosis (HP:0001414)2.33086119
38Distal lower limb amyotrophy (HP:0008944)2.30115377
39Glossoptosis (HP:0000162)2.26013009
40Abnormal trabecular bone morphology (HP:0100671)2.25991634
41Overriding aorta (HP:0002623)2.24898669
42Back pain (HP:0003418)2.22785855
43Difficulty climbing stairs (HP:0003551)2.22665695
44Increased nuchal translucency (HP:0010880)2.18649797
45Spinal rigidity (HP:0003306)2.18587389
46Spastic diplegia (HP:0001264)2.15221357
47Birth length less than 3rd percentile (HP:0003561)2.10807385
48Progressive hearing impairment (HP:0001730)2.07013159
49Flattened epiphyses (HP:0003071)2.06252353
50Abnormality of the hip-girdle musculature (HP:0001445)2.04140278
51Abnormality of the musculature of the pelvis (HP:0001469)2.04140278
52Breast hypoplasia (HP:0003187)2.03701934
53Poikiloderma (HP:0001029)2.02714307
54Cholecystitis (HP:0001082)1.98981732
55Abnormal gallbladder physiology (HP:0012438)1.98981732
56Long toe (HP:0010511)1.96478131
57Elfin facies (HP:0004428)1.95456016
58Fasciculations (HP:0002380)1.94483206
59Patellar dislocation (HP:0002999)1.93808918
60Reduced subcutaneous adipose tissue (HP:0003758)1.91613425
61Ankle contracture (HP:0006466)1.91309815
62Hypokinesia (HP:0002375)1.90682747
63Abnormality of the phalanges of the hallux (HP:0010057)1.89116842
64Hyperparathyroidism (HP:0000843)1.89094957
65Progressive sensorineural hearing impairment (HP:0000408)1.88205077
66Elbow flexion contracture (HP:0002987)1.88039203
67Pointed chin (HP:0000307)1.87656645
68Vertebral compression fractures (HP:0002953)1.84050598
69Orthostatic hypotension (HP:0001278)1.83539833
70Distal upper limb amyotrophy (HP:0007149)1.83375027
71Upper limb amyotrophy (HP:0009129)1.83375027
72Upper motor neuron abnormality (HP:0002127)1.82280550
73Horseshoe kidney (HP:0000085)1.81424843
74Bowed forearm bones (HP:0003956)1.80606188
75Bowing of the arm (HP:0006488)1.80606188
76Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78903962
77Short clavicles (HP:0000894)1.75108420
78High anterior hairline (HP:0009890)1.73245447
79Renal duplication (HP:0000075)1.72963347
80Abnormal foot bone ossification (HP:0010675)1.71951924
81Increased connective tissue (HP:0009025)1.71200816
82Insulin resistance (HP:0000855)1.70246469
83Congenital glaucoma (HP:0001087)1.69539257
84Abnormalities of placenta or umbilical cord (HP:0001194)1.68883170
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67793421
86Aplasia/Hypoplasia of the clavicles (HP:0006710)1.65399480
87Self-mutilation (HP:0000742)1.64734642
88Lower limb amyotrophy (HP:0007210)1.63890238
89Generalized amyotrophy (HP:0003700)1.63422678
90Ureteral duplication (HP:0000073)1.62540511
91Progressive external ophthalmoplegia (HP:0000590)1.62299402
92Hypoplastic pelvis (HP:0008839)1.62023320
93Reticulocytopenia (HP:0001896)1.61445957
94Secondary amenorrhea (HP:0000869)1.60896653
95Bilateral sensorineural hearing impairment (HP:0008619)1.60803005
96Overlapping toe (HP:0001845)1.60050616
97Generalized hypotonia (HP:0001290)1.59777083
98Abnormality of subcutaneous fat tissue (HP:0001001)1.59276791
99Chromsome breakage (HP:0040012)1.55012842
100Abnormality of the astrocytes (HP:0100707)1.52755838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.80731612
2SMG13.77854450
3IRAK33.74949992
4NME23.71222692
5TRIB33.68266870
6TESK22.34430255
7CDK122.25175219
8EEF2K2.16941347
9CDC72.14264130
10VRK22.06822265
11EPHA21.91896004
12ARAF1.85518346
13TSSK61.81591478
14TESK11.79786932
15NEK11.73215328
16MAP3K111.72825671
17TAOK21.71855614
18AURKA1.57407788
19BRAF1.49869983
20PRPF4B1.48848147
21MAP3K81.47701162
22CDK81.47075493
23TTK1.45984797
24ICK1.45339908
25CHEK21.41401488
26LIMK11.39640553
27STK101.36301305
28PAK41.35854070
29SRPK11.31409338
30TTN1.16737426
31PBK1.11322569
32LATS21.07268548
33CDK71.06621362
34MAP3K91.02258812
35AURKB1.00643537
36ILK0.99583866
37SIK10.97347915
38MAP3K100.97017535
39MAP2K70.95336384
40PLK10.95174585
41PIM20.95028753
42BRSK10.93762700
43NEK20.93717349
44RPS6KB20.90256916
45MST1R0.89463058
46RPS6KA40.89362274
47VRK10.89335163
48CHEK10.88298744
49CDK40.87068617
50BCKDK0.85412055
51ATR0.84987891
52IRAK40.84144182
53SCYL20.83068583
54TAF10.82025925
55KDR0.79324174
56CDK90.78821574
57ERBB40.75598322
58CAMK1D0.75277499
59PAK10.74542284
60PKN20.74033678
61IRAK20.73234974
62MOS0.72849087
63AKT20.70102391
64CDK11A0.68080256
65CDK140.63620199
66CDK150.63088004
67TAOK10.62438583
68PTK20.61770923
69CDK180.60997990
70PRKCI0.60936061
71ERN10.60696085
72STK40.60566212
73CCNB10.57078942
74DAPK30.57077909
75MTOR0.56795301
76MAPK110.56672276
77TLK10.54635313
78ABL20.54475916
79SIK30.53329320
80STK160.53239582
81PLK30.51292838
82DYRK30.51023441
83LRRK20.50594332
84DAPK10.49542494
85WEE10.48713472
86MAP3K140.47749676
87MAP2K30.47057488
88LMTK20.45484569
89CSNK1G30.45226252
90RPS6KA50.42596174
91CAMK1G0.41734485
92ALK0.41573712
93MAP3K50.39664501
94CDK10.39554943
95CDK20.39196723
96TBK10.39006304
97ZAK0.38262216
98MELK0.37512212
99PDGFRA0.37380317
100EIF2AK30.36540225

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.13944406
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71418716
3Base excision repair_Homo sapiens_hsa034102.71025387
4Spliceosome_Homo sapiens_hsa030402.51632876
5Cell cycle_Homo sapiens_hsa041102.40687075
6Mismatch repair_Homo sapiens_hsa034302.40160387
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31621246
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09934528
9RNA transport_Homo sapiens_hsa030132.02844200
10Pyrimidine metabolism_Homo sapiens_hsa002402.02419487
11Proteasome_Homo sapiens_hsa030501.88227970
12Biosynthesis of amino acids_Homo sapiens_hsa012301.87881806
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86488128
14Bladder cancer_Homo sapiens_hsa052191.84908578
15Sulfur relay system_Homo sapiens_hsa041221.81768371
16Nucleotide excision repair_Homo sapiens_hsa034201.80235761
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66868000
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65827400
19mRNA surveillance pathway_Homo sapiens_hsa030151.65573148
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63656825
21Pentose phosphate pathway_Homo sapiens_hsa000301.54458481
22Shigellosis_Homo sapiens_hsa051311.51890315
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.50987817
24Vibrio cholerae infection_Homo sapiens_hsa051101.42239059
25Systemic lupus erythematosus_Homo sapiens_hsa053221.40650983
26RNA polymerase_Homo sapiens_hsa030201.38684994
27Ribosome_Homo sapiens_hsa030101.35900904
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35301112
29Epstein-Barr virus infection_Homo sapiens_hsa051691.33152362
30Viral carcinogenesis_Homo sapiens_hsa052031.33018901
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31218860
32Apoptosis_Homo sapiens_hsa042101.18290638
33One carbon pool by folate_Homo sapiens_hsa006701.15653999
34Non-homologous end-joining_Homo sapiens_hsa034501.11705486
35Carbon metabolism_Homo sapiens_hsa012001.11527886
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.07986592
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06515256
38Selenocompound metabolism_Homo sapiens_hsa004501.06237633
39Chronic myeloid leukemia_Homo sapiens_hsa052201.04665764
40Salmonella infection_Homo sapiens_hsa051321.04255303
41Alcoholism_Homo sapiens_hsa050341.03560146
42Pancreatic cancer_Homo sapiens_hsa052121.03158931
43Vitamin B6 metabolism_Homo sapiens_hsa007501.03030256
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02669785
45Fructose and mannose metabolism_Homo sapiens_hsa000510.97723385
46Homologous recombination_Homo sapiens_hsa034400.92342666
47p53 signaling pathway_Homo sapiens_hsa041150.90645015
48HTLV-I infection_Homo sapiens_hsa051660.89491274
49Galactose metabolism_Homo sapiens_hsa000520.89149418
50Herpes simplex infection_Homo sapiens_hsa051680.88849919
51Prion diseases_Homo sapiens_hsa050200.88299707
52Hepatitis B_Homo sapiens_hsa051610.86545729
53N-Glycan biosynthesis_Homo sapiens_hsa005100.85704602
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85682972
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84241886
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83135817
57Thyroid cancer_Homo sapiens_hsa052160.78715686
58Basal transcription factors_Homo sapiens_hsa030220.78500066
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76843029
60Oocyte meiosis_Homo sapiens_hsa041140.75725744
61Non-small cell lung cancer_Homo sapiens_hsa052230.72463650
62Viral myocarditis_Homo sapiens_hsa054160.71770996
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71589871
64Fanconi anemia pathway_Homo sapiens_hsa034600.71512730
65Influenza A_Homo sapiens_hsa051640.71212003
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70826794
67MicroRNAs in cancer_Homo sapiens_hsa052060.68655134
68Acute myeloid leukemia_Homo sapiens_hsa052210.66358155
69Purine metabolism_Homo sapiens_hsa002300.66232336
70Sulfur metabolism_Homo sapiens_hsa009200.65722602
71Hippo signaling pathway_Homo sapiens_hsa043900.64252342
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.63580222
73Legionellosis_Homo sapiens_hsa051340.63459409
74Folate biosynthesis_Homo sapiens_hsa007900.63008359
75RNA degradation_Homo sapiens_hsa030180.58378721
76Small cell lung cancer_Homo sapiens_hsa052220.57243620
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56862065
78Adherens junction_Homo sapiens_hsa045200.56002761
79Hepatitis C_Homo sapiens_hsa051600.55962317
80Colorectal cancer_Homo sapiens_hsa052100.55845848
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54973445
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53862310
83Melanoma_Homo sapiens_hsa052180.53623867
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.51742771
85TNF signaling pathway_Homo sapiens_hsa046680.49909265
86Endometrial cancer_Homo sapiens_hsa052130.47639246
87Prostate cancer_Homo sapiens_hsa052150.47117138
88B cell receptor signaling pathway_Homo sapiens_hsa046620.46270151
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.44655660
90Glioma_Homo sapiens_hsa052140.44390908
91VEGF signaling pathway_Homo sapiens_hsa043700.43469849
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42512309
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.41669474
94Steroid biosynthesis_Homo sapiens_hsa001000.40935488
95Renal cell carcinoma_Homo sapiens_hsa052110.40813948
96AMPK signaling pathway_Homo sapiens_hsa041520.39978017
97Proteoglycans in cancer_Homo sapiens_hsa052050.39025246
98ErbB signaling pathway_Homo sapiens_hsa040120.38108120
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36926923
100Pyruvate metabolism_Homo sapiens_hsa006200.36234725

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