UBE2V1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of nitric-oxide synthase activity (GO:0051001)5.65820395
2activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO5.62524629
3ribonucleoprotein complex disassembly (GO:0032988)5.58128128
4regulation of sarcomere organization (GO:0060297)5.25018724
5formation of translation preinitiation complex (GO:0001731)5.08028660
6organelle disassembly (GO:1903008)5.07096142
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.03277282
8cullin deneddylation (GO:0010388)5.00325674
9negative regulation of protein localization to cell surface (GO:2000009)4.94210422
10membrane raft organization (GO:0031579)4.84129334
11proteasome assembly (GO:0043248)4.77493394
12protein deneddylation (GO:0000338)4.74051063
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.61864106
14nucleobase biosynthetic process (GO:0046112)4.55607871
15DNA deamination (GO:0045006)4.54644575
16purine nucleobase biosynthetic process (GO:0009113)4.54074213
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.52410562
18plasma membrane repair (GO:0001778)4.51719037
19establishment of integrated proviral latency (GO:0075713)4.41338389
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.39114208
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.36268182
22negative regulation of cardiac muscle tissue growth (GO:0055022)4.33295017
23negative regulation of heart growth (GO:0061117)4.33295017
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.30833678
25negative regulation of organelle assembly (GO:1902116)4.26720532
26DNA strand elongation involved in DNA replication (GO:0006271)4.23588869
27maturation of SSU-rRNA (GO:0030490)4.21928703
28regulation of skeletal muscle contraction (GO:0014819)4.21162468
29negative regulation of muscle hypertrophy (GO:0014741)4.20417614
30negative regulation of potassium ion transmembrane transport (GO:1901380)4.20387331
31negative regulation of ligase activity (GO:0051352)4.20278398
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.20278398
33ribosome assembly (GO:0042255)4.17545374
34ribosomal small subunit assembly (GO:0000028)4.08287761
35DNA strand elongation (GO:0022616)4.04475500
36telomere maintenance via semi-conservative replication (GO:0032201)4.00834015
37ATP synthesis coupled proton transport (GO:0015986)3.93936337
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93936337
39positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.92501694
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.91490149
41ribosome biogenesis (GO:0042254)3.88700711
42peptidyl-arginine omega-N-methylation (GO:0035247)3.86616966
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.85711382
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.85711382
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.83758333
46signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.83743633
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.83743633
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.83743633
49regulation of cellular amino acid metabolic process (GO:0006521)3.82892900
50DNA replication checkpoint (GO:0000076)3.81701150
51signal transduction involved in DNA integrity checkpoint (GO:0072401)3.79236705
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.79236705
53spliceosomal snRNP assembly (GO:0000387)3.78728828
54signal transduction involved in cell cycle checkpoint (GO:0072395)3.75561309
55IMP biosynthetic process (GO:0006188)3.72966297
56positive regulation of ligase activity (GO:0051351)3.69590098
57histone arginine methylation (GO:0034969)3.67492458
58establishment of viral latency (GO:0019043)3.58164429
59telomere maintenance via recombination (GO:0000722)3.57008152
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.47700176
61DNA ligation (GO:0006266)3.47409063
62regulation of spindle organization (GO:0090224)3.47193155
63regulation of ubiquitin-protein transferase activity (GO:0051438)3.46639568
64negative regulation of monooxygenase activity (GO:0032769)3.45260986
65DNA replication initiation (GO:0006270)3.44724718
66protein neddylation (GO:0045116)3.44221236
67negative regulation of cardiac muscle hypertrophy (GO:0010614)3.43407176
68negative regulation of cell size (GO:0045792)3.39361026
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38246239
70regulation of cellular amine metabolic process (GO:0033238)3.36958578
71de novo protein folding (GO:0006458)3.35912701
72viral mRNA export from host cell nucleus (GO:0046784)3.35349902
73chaperone-mediated protein transport (GO:0072321)3.34203960
74termination of RNA polymerase III transcription (GO:0006386)3.33860083
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.33860083
76de novo posttranslational protein folding (GO:0051084)3.33485172
77ribonucleoprotein complex biogenesis (GO:0022613)3.33175695
78mitotic recombination (GO:0006312)3.29983251
79peptidyl-arginine methylation (GO:0018216)3.29596671
80peptidyl-arginine N-methylation (GO:0035246)3.29596671
81regulation of ligase activity (GO:0051340)3.29349634
82negative regulation of cardiac muscle tissue development (GO:0055026)3.28230156
83rRNA modification (GO:0000154)3.28033460
84cell cycle G1/S phase transition (GO:0044843)3.26636515
85G1/S transition of mitotic cell cycle (GO:0000082)3.26636515
86transcription-coupled nucleotide-excision repair (GO:0006283)3.25022597
87positive regulation of cell cycle arrest (GO:0071158)3.23873822
88maturation of 5.8S rRNA (GO:0000460)3.23579884
89telomere maintenance via telomere lengthening (GO:0010833)3.22777477
90nucleobase-containing small molecule interconversion (GO:0015949)3.21900768
91positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.21605998
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21300848
937-methylguanosine mRNA capping (GO:0006370)3.20876897
94ribosomal large subunit biogenesis (GO:0042273)3.19264060
95mitotic metaphase plate congression (GO:0007080)3.19098323
96translational initiation (GO:0006413)3.16718634
97NADH metabolic process (GO:0006734)3.14111032
98mitotic nuclear envelope disassembly (GO:0007077)3.13745562
99pseudouridine synthesis (GO:0001522)3.13396236
100regulation of mitochondrial translation (GO:0070129)3.12350008
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.11737360
102negative regulation of protein ubiquitination (GO:0031397)3.10660423
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09864377
104COPI coating of Golgi vesicle (GO:0048205)3.09825807
105Golgi transport vesicle coating (GO:0048200)3.09825807
1067-methylguanosine RNA capping (GO:0009452)3.09677041
107RNA capping (GO:0036260)3.09677041
108DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.08444704
109establishment of protein localization to mitochondrial membrane (GO:0090151)3.08292009
110respiratory electron transport chain (GO:0022904)3.07443536
111protein maturation by protein folding (GO:0022417)3.05742745
112RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05655681
113tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05655681
114oxidative phosphorylation (GO:0006119)3.04929870
115translational elongation (GO:0006414)3.03836070
116rRNA processing (GO:0006364)3.03581594
117L-methionine salvage (GO:0071267)3.02105690
118L-methionine biosynthetic process (GO:0071265)3.02105690
119amino acid salvage (GO:0043102)3.02105690
120spliceosomal complex assembly (GO:0000245)3.02084740
121electron transport chain (GO:0022900)3.00679603
122translation (GO:0006412)3.00530465
123DNA unwinding involved in DNA replication (GO:0006268)2.99997528
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.98565496
125viral transcription (GO:0019083)2.97308572
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97140279
127mitotic sister chromatid segregation (GO:0000070)2.96230686
128IMP metabolic process (GO:0046040)2.95854453
129protein targeting to mitochondrion (GO:0006626)2.94672526
130negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.93317956
131regulation of translational termination (GO:0006449)2.92776063
132translational termination (GO:0006415)2.91953031
133rRNA metabolic process (GO:0016072)2.91354312
134nuclear envelope disassembly (GO:0051081)2.90950112
135membrane disassembly (GO:0030397)2.90950112
136amino acid activation (GO:0043038)2.89689104
137tRNA aminoacylation (GO:0043039)2.89689104
138deoxyribonucleotide biosynthetic process (GO:0009263)2.88111550
139folic acid-containing compound biosynthetic process (GO:0009396)2.87347664
140cellular component biogenesis (GO:0044085)2.86950346
141tRNA aminoacylation for protein translation (GO:0006418)2.86341834
142DNA catabolic process, exonucleolytic (GO:0000738)2.82999010
143negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.80145954
144negative regulation of cell cycle G1/S phase transition (GO:1902807)2.80145954
145CENP-A containing nucleosome assembly (GO:0034080)2.78518046
146positive regulation of protein ubiquitination (GO:0031398)2.75592493
147regulation of cell cycle arrest (GO:0071156)2.74561847
148pteridine-containing compound biosynthetic process (GO:0042559)2.73514138
149signal transduction in response to DNA damage (GO:0042770)2.73466035
150regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.69496871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.47864542
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.58806291
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.16957480
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65087441
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60911625
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.40288455
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.36409910
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.26995696
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12821698
10* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08915266
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01318125
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00515694
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99674227
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80563806
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.67758296
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.66613536
17XRN2_22483619_ChIP-Seq_HELA_Human2.60479211
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52128495
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44159838
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33833132
21* GABP_19822575_ChIP-Seq_HepG2_Human2.29808421
22VDR_22108803_ChIP-Seq_LS180_Human2.29093259
23VDR_23849224_ChIP-Seq_CD4+_Human2.27107494
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24906415
25DCP1A_22483619_ChIP-Seq_HELA_Human2.19976325
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16164893
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15077655
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12933529
29FOXP3_21729870_ChIP-Seq_TREG_Human2.09936684
30* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07261263
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.05259682
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02535262
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.99562423
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91380824
35TTF2_22483619_ChIP-Seq_HELA_Human1.90244558
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88536181
37CIITA_25753668_ChIP-Seq_RAJI_Human1.84726889
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.81800873
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81157348
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78619363
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78617503
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76847894
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71930351
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70808179
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70324801
46MYC_22102868_ChIP-Seq_BL_Human1.66311835
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63315593
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62624479
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61661432
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57592520
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56618659
52KDM5A_27292631_Chip-Seq_BREAST_Human1.50994556
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49523078
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49082292
55ELK1_19687146_ChIP-ChIP_HELA_Human1.41399434
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40274178
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39945401
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.39318438
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.36559625
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35481898
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33305533
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32463195
63AR_21909140_ChIP-Seq_LNCAP_Human1.31771231
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30573862
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30179805
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28988199
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27464954
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25730158
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24891381
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22176453
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19951256
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.17257694
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16627739
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16103246
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15625094
76* TFEB_21752829_ChIP-Seq_HELA_Human1.14799744
77* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13661512
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13288108
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13190370
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11701197
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10285098
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08506636
83* ELK1_22589737_ChIP-Seq_MCF10A_Human1.07825055
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07243410
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05404133
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03655192
87* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02916175
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02611413
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02355464
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01977765
91* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01900103
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01718099
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98507564
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97969808
95* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97662207
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.97478563
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.96511489
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96359551
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95596843
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95440148
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95206244
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94358141
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93593000
104MYC_18940864_ChIP-ChIP_HL60_Human0.93140659
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92769996
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91118070
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.91033576
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89575049
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88741637
110VDR_21846776_ChIP-Seq_THP-1_Human0.87233892
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86745724
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.86491271
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.86165011
114ELF5_23300383_ChIP-Seq_T47D_Human0.85775998
115* KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85415155
116* KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85415155
117* KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85415155
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80489910
119* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78998424
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76768491
121EOMES_21245162_ChIP-Seq_HESCs_Human0.74783847
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73943721
123ZNF274_21170338_ChIP-Seq_K562_Hela0.72998757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane7.41813231
2MP0003693_abnormal_embryo_hatching5.21258470
3MP0004957_abnormal_blastocyst_morpholog4.71813321
4MP0003111_abnormal_nucleus_morphology4.06650255
5MP0002102_abnormal_ear_morphology3.86989989
6MP0003077_abnormal_cell_cycle3.58197715
7MP0010094_abnormal_chromosome_stability3.57902407
8MP0008058_abnormal_DNA_repair3.08039125
9MP0003123_paternal_imprinting3.07029990
10MP0008007_abnormal_cellular_replicative3.04785835
11MP0008932_abnormal_embryonic_tissue3.04640861
12MP0009697_abnormal_copulation2.61906538
13MP0002653_abnormal_ependyma_morphology2.38314212
14MP0008877_abnormal_DNA_methylation2.29087178
15MP0001730_embryonic_growth_arrest2.21406943
16MP0010030_abnormal_orbit_morphology2.03560267
17MP0000350_abnormal_cell_proliferation1.99460140
18MP0001293_anophthalmia1.98810187
19MP0004272_abnormal_basement_membrane1.92402668
20MP0003786_premature_aging1.87400006
21MP0001697_abnormal_embryo_size1.85050011
22MP0003122_maternal_imprinting1.82535786
23MP0005330_cardiomyopathy1.81503863
24MP0004233_abnormal_muscle_weight1.77793492
25MP0002080_prenatal_lethality1.72400218
26MP0009333_abnormal_splenocyte_physiolog1.70520582
27MP0003646_muscle_fatigue1.67119826
28MP0001853_heart_inflammation1.66564254
29MP0002396_abnormal_hematopoietic_system1.64905895
30MP0001672_abnormal_embryogenesis/_devel1.55171402
31MP0005380_embryogenesis_phenotype1.55171402
32MP0010368_abnormal_lymphatic_system1.54750396
33MP0009780_abnormal_chondrocyte_physiolo1.51460748
34MP0000358_abnormal_cell_content/1.51142233
35MP0003984_embryonic_growth_retardation1.50554754
36MP0004084_abnormal_cardiac_muscle1.47943524
37MP0005623_abnormal_meninges_morphology1.47554073
38MP0002088_abnormal_embryonic_growth/wei1.47122243
39MP0003119_abnormal_digestive_system1.45909299
40MP0006036_abnormal_mitochondrial_physio1.44480600
41MP0000313_abnormal_cell_death1.42905501
42MP0000490_abnormal_crypts_of1.41999297
43MP0006035_abnormal_mitochondrial_morpho1.39747144
44MP0000750_abnormal_muscle_regeneration1.38958060
45MP0005408_hypopigmentation1.38512221
46MP0000678_abnormal_parathyroid_gland1.36815325
47MP0008057_abnormal_DNA_replication1.34915889
48MP0010352_gastrointestinal_tract_polyps1.34771604
49MP0000013_abnormal_adipose_tissue1.34704102
50MP0006054_spinal_hemorrhage1.33413531
51MP0002085_abnormal_embryonic_tissue1.32393488
52MP0002160_abnormal_reproductive_system1.28603301
53MP0002019_abnormal_tumor_incidence1.28389165
54MP0003121_genomic_imprinting1.26270831
55MP0004808_abnormal_hematopoietic_stem1.21492765
56MP0002132_abnormal_respiratory_system1.20169791
57MP0002084_abnormal_developmental_patter1.19682148
58MP0004133_heterotaxia1.19649503
59MP0008872_abnormal_physiological_respon1.19144352
60MP0000858_altered_metastatic_potential1.18006269
61MP0008789_abnormal_olfactory_epithelium1.17772459
62MP0000749_muscle_degeneration1.16615676
63MP0003315_abnormal_perineum_morphology1.13330778
64MP0002938_white_spotting1.13052961
65MP0002877_abnormal_melanocyte_morpholog1.10536206
66MP0006292_abnormal_olfactory_placode1.09738016
67MP0003718_maternal_effect1.08754742
68MP0003941_abnormal_skin_development1.08519770
69MP0000372_irregular_coat_pigmentation1.08160244
70MP0009053_abnormal_anal_canal1.07089462
71MP0002751_abnormal_autonomic_nervous1.07036042
72MP0005501_abnormal_skin_physiology1.06138816
73MP0003221_abnormal_cardiomyocyte_apopto1.05109648
74MP0004197_abnormal_fetal_growth/weight/1.04934005
75MP0001529_abnormal_vocalization1.04106849
76MP0003942_abnormal_urinary_system1.03861430
77MP0002086_abnormal_extraembryonic_tissu1.02111383
78MP0000703_abnormal_thymus_morphology1.01837553
79MP0003656_abnormal_erythrocyte_physiolo1.01617024
80MP0005394_taste/olfaction_phenotype1.01162477
81MP0005499_abnormal_olfactory_system1.01162477
82MP0002269_muscular_atrophy0.98293722
83MP0001545_abnormal_hematopoietic_system0.95563763
84MP0005397_hematopoietic_system_phenotyp0.95563763
85MP0003763_abnormal_thymus_physiology0.95223302
86MP0003806_abnormal_nucleotide_metabolis0.94378235
87MP0003567_abnormal_fetal_cardiomyocyte0.92910853
88MP0009672_abnormal_birth_weight0.90338992
89MP0000647_abnormal_sebaceous_gland0.88616494
90MP0003186_abnormal_redox_activity0.87874793
91MP0002722_abnormal_immune_system0.86749878
92MP0001542_abnormal_bone_strength0.86599404
93MP0008775_abnormal_heart_ventricle0.86504662
94MP0005395_other_phenotype0.86434611
95MP0004036_abnormal_muscle_relaxation0.86388224
96MP0000467_abnormal_esophagus_morphology0.85995455
97MP0005384_cellular_phenotype0.85964908
98MP0001986_abnormal_taste_sensitivity0.83263616
99MP0010307_abnormal_tumor_latency0.82408866
100MP0004147_increased_porphyrin_level0.81588472
101MP0001873_stomach_inflammation0.81339850
102MP0002972_abnormal_cardiac_muscle0.81329123
103MP0005083_abnormal_biliary_tract0.80673549
104MP0002398_abnormal_bone_marrow0.80425482
105MP0005360_urolithiasis0.79928627
106MP0000751_myopathy0.79907650
107MP0001764_abnormal_homeostasis0.79226401
108MP0000049_abnormal_middle_ear0.78900040
109MP0005389_reproductive_system_phenotype0.77931898
110MP0008260_abnormal_autophagy0.77369377
111MP0005084_abnormal_gallbladder_morpholo0.75776546
112MP0001919_abnormal_reproductive_system0.75553665
113MP0001661_extended_life_span0.74161598
114MP0000689_abnormal_spleen_morphology0.72613639
115MP0003890_abnormal_embryonic-extraembry0.72504662
116MP0005187_abnormal_penis_morphology0.71723138
117MP0003115_abnormal_respiratory_system0.71136221
118MP0002233_abnormal_nose_morphology0.70793186
119MP0001881_abnormal_mammary_gland0.70309500
120MP0002089_abnormal_postnatal_growth/wei0.70239295
121MP0001544_abnormal_cardiovascular_syste0.67638261
122MP0005385_cardiovascular_system_phenoty0.67638261
123MP0005621_abnormal_cell_physiology0.67634244
124MP0010630_abnormal_cardiac_muscle0.66085467
125MP0000534_abnormal_ureter_morphology0.66056027
126MP0002111_abnormal_tail_morphology0.65824563
127MP0001485_abnormal_pinna_reflex0.65778169
128MP0005023_abnormal_wound_healing0.65608688
129MP0004087_abnormal_muscle_fiber0.65278248
130MP0002210_abnormal_sex_determination0.63507206
131MP0002429_abnormal_blood_cell0.62987491
132MP0002234_abnormal_pharynx_morphology0.62940942
133MP0003385_abnormal_body_wall0.61953334
134MP0004215_abnormal_myocardial_fiber0.61688813
135MP0002106_abnormal_muscle_physiology0.60417289
136MP0003011_delayed_dark_adaptation0.59959533
137MP0000759_abnormal_skeletal_muscle0.59826778
138MP0005266_abnormal_metabolism0.59089395
139MP0002127_abnormal_cardiovascular_syste0.58392897
140MP0003787_abnormal_imprinting0.57982291
141MP0005332_abnormal_amino_acid0.55910795
142MP0001666_abnormal_nutrient_absorption0.55855392

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)6.04580397
2Calf muscle hypertrophy (HP:0008981)5.45848938
3Abnormality of the left ventricular outflow tract (HP:0011103)4.79830190
4Subaortic stenosis (HP:0001682)4.79830190
5Exercise-induced myalgia (HP:0003738)4.76363046
6Muscle hypertrophy of the lower extremities (HP:0008968)4.71288413
7Abnormality of the anterior horn cell (HP:0006802)4.42833333
8Degeneration of anterior horn cells (HP:0002398)4.42833333
9Renal cortical cysts (HP:0000803)3.96037136
10Muscle stiffness (HP:0003552)3.89146282
11Hepatocellular necrosis (HP:0001404)3.72993916
12Cerebral hypomyelination (HP:0006808)3.71082615
13Oral leukoplakia (HP:0002745)3.44340754
14Hypoplasia of the thymus (HP:0000778)3.40398509
15Birth length less than 3rd percentile (HP:0003561)3.39663014
16Hepatic necrosis (HP:0002605)3.26749745
17Sudden death (HP:0001699)3.24004693
18Aplastic anemia (HP:0001915)3.18554357
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18005988
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18005988
21Abnormal mitochondria in muscle tissue (HP:0008316)3.13211155
22Atrophy/Degeneration involving motor neurons (HP:0007373)3.10566722
23Myotonia (HP:0002486)3.07488937
24Mitochondrial inheritance (HP:0001427)2.99304796
25Trismus (HP:0000211)2.95981674
26Abnormal gallbladder physiology (HP:0012438)2.94804908
27Cholecystitis (HP:0001082)2.94804908
28Acute necrotizing encephalopathy (HP:0006965)2.90043680
29Increased CSF lactate (HP:0002490)2.89687830
30Abnormal number of erythroid precursors (HP:0012131)2.89518778
31Increased serum lactate (HP:0002151)2.88071586
32Carpal bone hypoplasia (HP:0001498)2.84801745
33Rough bone trabeculation (HP:0100670)2.84101960
34Abnormality of glycolysis (HP:0004366)2.83904712
35Increased serum pyruvate (HP:0003542)2.83904712
36Amniotic constriction ring (HP:0009775)2.83607657
37Abnormality of placental membranes (HP:0011409)2.83607657
38Neck muscle weakness (HP:0000467)2.82414463
39Patellar aplasia (HP:0006443)2.77547146
40Abnormality of cells of the erythroid lineage (HP:0012130)2.75725325
41Breast hypoplasia (HP:0003187)2.75271321
42Distal lower limb muscle weakness (HP:0009053)2.71139503
43Asymmetric septal hypertrophy (HP:0001670)2.67187653
44Emotional lability (HP:0000712)2.63795847
45Abnormality of methionine metabolism (HP:0010901)2.63715221
46Aplasia/Hypoplasia of the patella (HP:0006498)2.62667667
47Unsteady gait (HP:0002317)2.60890852
48Agnosia (HP:0010524)2.58507764
49Colon cancer (HP:0003003)2.54670348
50Cerebral edema (HP:0002181)2.51293173
51Posterior subcapsular cataract (HP:0007787)2.50349749
52Abnormal cartilage morphology (HP:0002763)2.49678732
53Multiple enchondromatosis (HP:0005701)2.48696945
54Increased hepatocellular lipid droplets (HP:0006565)2.41122460
55Arterial tortuosity (HP:0005116)2.40659858
56Reduced subcutaneous adipose tissue (HP:0003758)2.39279690
57Selective tooth agenesis (HP:0001592)2.39004451
58Reticulocytopenia (HP:0001896)2.37519419
59Reduced antithrombin III activity (HP:0001976)2.35175996
60Abnormality of the labia minora (HP:0012880)2.33293617
61Prominent metopic ridge (HP:0005487)2.30902520
62Hypoplasia of the pons (HP:0012110)2.28881272
63Renal Fanconi syndrome (HP:0001994)2.28055558
64Shoulder girdle muscle weakness (HP:0003547)2.25774674
65Abnormality of the calf musculature (HP:0001430)2.25587754
66Lactic acidosis (HP:0003128)2.25284741
67CNS demyelination (HP:0007305)2.22526981
68Exercise intolerance (HP:0003546)2.21427421
69Vascular tortuosity (HP:0004948)2.18920399
70Microretrognathia (HP:0000308)2.18540477
71Slender long bone (HP:0003100)2.18355263
72Postnatal microcephaly (HP:0005484)2.17649076
73Poor suck (HP:0002033)2.17374147
74Palpitations (HP:0001962)2.17252015
75Tongue fasciculations (HP:0001308)2.15237641
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12808089
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12237831
78Upper limb muscle weakness (HP:0003484)2.12153080
79Neoplasm of the pancreas (HP:0002894)2.11837038
80Neoplasm of the adrenal gland (HP:0100631)2.11690766
81Respiratory failure (HP:0002878)2.11099352
82Neuroendocrine neoplasm (HP:0100634)2.09656339
83Adenoma sebaceum (HP:0009720)2.09463068
84Angiofibromas (HP:0010615)2.09463068
85Abnormality of the metopic suture (HP:0005556)2.08849772
86Sparse eyelashes (HP:0000653)2.07710205
87Neuroblastoma (HP:0003006)2.07675920
88Primitive neuroectodermal tumor (HP:0030065)2.07675920
89Neuroblastic tumors (HP:0004376)2.07675920
90Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.07675920
91Aplasia/Hypoplasia of the thymus (HP:0010515)2.07552846
92Acute encephalopathy (HP:0006846)2.06750782
93Muscle fiber atrophy (HP:0100295)2.06551552
94Abnormality of the aortic arch (HP:0012303)2.06134742
95Neoplasm of the peripheral nervous system (HP:0100007)2.05902520
96Muscle fibrillation (HP:0010546)2.05254635
97Ragged-red muscle fibers (HP:0003200)2.05214229
98Abnormality of the umbilical cord (HP:0010881)2.04696176
99Brushfield spots (HP:0001088)2.04654523
10011 pairs of ribs (HP:0000878)2.04637793
101Poor head control (HP:0002421)2.03864303
102Premature graying of hair (HP:0002216)2.03325539
103Type I transferrin isoform profile (HP:0003642)2.01768895
104Pancytopenia (HP:0001876)2.01027329
105Lipid accumulation in hepatocytes (HP:0006561)2.00819759
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99354284
107Abnormal protein N-linked glycosylation (HP:0012347)1.99354284
108Abnormal protein glycosylation (HP:0012346)1.99354284
109Abnormal glycosylation (HP:0012345)1.99354284
110Progressive macrocephaly (HP:0004481)1.99058996
111Optic nerve coloboma (HP:0000588)1.98829800
112Absent thumb (HP:0009777)1.98784493
113Medulloblastoma (HP:0002885)1.98775889
114Secondary amenorrhea (HP:0000869)1.98671201
115Vertebral compression fractures (HP:0002953)1.98667874
116Hypoplastic pelvis (HP:0008839)1.97383422
117Progressive muscle weakness (HP:0003323)1.97297703
118Pheochromocytoma (HP:0002666)1.93814988
119Abnormality of the heme biosynthetic pathway (HP:0010472)1.93753821
120Premature ovarian failure (HP:0008209)1.92885162
121Gowers sign (HP:0003391)1.92646443
122Abnormalities of placenta or umbilical cord (HP:0001194)1.91446693
123Cleft eyelid (HP:0000625)1.91274917
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88989385
125Macrocytic anemia (HP:0001972)1.88843772
126Type 2 muscle fiber atrophy (HP:0003554)1.87809087
127Hepatosplenomegaly (HP:0001433)1.87720379
128Ependymoma (HP:0002888)1.87378794
129Abnormal trabecular bone morphology (HP:0100671)1.86193133
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86016028
131Abnormality of alanine metabolism (HP:0010916)1.86016028
132Hyperalaninemia (HP:0003348)1.86016028
133Pelvic girdle muscle weakness (HP:0003749)1.85944567
134Abnormality of the motor neurons (HP:0002450)1.85465174
135Abnormal neuron morphology (HP:0012757)1.85465174
136Methylmalonic acidemia (HP:0002912)1.84481114
137Neoplasm of head and neck (HP:0012288)1.84304738
138Esophageal neoplasm (HP:0100751)1.84304738
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83198812
140Clitoromegaly (HP:0000057)1.82374399
1413-Methylglutaconic aciduria (HP:0003535)1.82136026
142Generalized aminoaciduria (HP:0002909)1.80566834
143Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80062323
144Protrusio acetabuli (HP:0003179)1.78552317
145Cellular immunodeficiency (HP:0005374)1.77697674
146Lethargy (HP:0001254)1.76883100
147Delusions (HP:0000746)1.75781676
148Meckel diverticulum (HP:0002245)1.75236719
149Long palpebral fissure (HP:0000637)1.75230097
150Horseshoe kidney (HP:0000085)1.75081702
151Nephroblastoma (Wilms tumor) (HP:0002667)1.75057252
152Abnormal lung lobation (HP:0002101)1.74623612
153Abnormality of the ileum (HP:0001549)1.74489655
154Microvesicular hepatic steatosis (HP:0001414)1.74263451
155Microglossia (HP:0000171)1.73054061
156Brittle hair (HP:0002299)1.70677056
157Prolonged partial thromboplastin time (HP:0003645)1.68954954
158Leukodystrophy (HP:0002415)1.68725124
159Skin nodule (HP:0200036)1.65867386
160Palpebral edema (HP:0100540)1.65733838
161Hypoglycemic coma (HP:0001325)1.65670874
162Small epiphyses (HP:0010585)1.65212781
163Embryonal renal neoplasm (HP:0011794)1.64964643
164Abnormality of the preputium (HP:0100587)1.64678469
165Increased intramyocellular lipid droplets (HP:0012240)1.62673111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.80398447
2EIF2AK13.93721210
3VRK23.65706903
4NEK13.40498013
5TSSK63.39206172
6MAPKAPK53.31830354
7TESK22.96143038
8MST42.95056953
9WEE12.65967876
10CCNB12.55388975
11STK162.52254113
12MUSK2.34077461
13MAP3K122.30331038
14SRPK12.28013571
15TESK12.26217064
16TRIM282.21277534
17TLK12.07399065
18CDC72.07356730
19PBK2.06408977
20PIM21.76953828
21NME21.73942560
22BRSK11.70321934
23DAPK11.65814451
24MAP3K111.58902416
25BRAF1.56912578
26CDK191.53952074
27LIMK11.49214108
28KDR1.47857322
29PLK41.46722707
30PLK11.44574489
31EIF2AK31.44228837
32DMPK1.42259172
33PLK31.39863866
34AKT31.39579924
35SIK31.37778661
36CASK1.36951068
37RPS6KA41.36631023
38BRSK21.34217384
39CLK11.32611786
40SCYL21.31563783
41ACVR1B1.30753777
42PAK41.26990951
43NUAK11.26965124
44NME11.24173428
45AURKA1.22166615
46EPHA21.18518276
47MYLK1.17886363
48NEK21.10757186
49CDK81.07781998
50VRK11.07412914
51TTK1.04979218
52TAOK21.04226401
53AURKB1.04021555
54TGFBR11.03743848
55PASK1.00746344
56EIF2AK20.98048162
57TRIB30.97416194
58CDK70.95458515
59CDK90.95122595
60DAPK30.92083104
61MKNK10.90360666
62ATR0.89447052
63ILK0.84333072
64LATS20.83367851
65PDK40.82543547
66PDK30.82543547
67BCR0.80067617
68PIK3CA0.78855618
69MKNK20.78133314
70MELK0.77948374
71ERBB40.76657434
72BCKDK0.75999374
73PTK20.74828629
74MINK10.73337495
75PRKCI0.72969313
76PKN20.72884112
77MOS0.71422127
78PAK10.71395229
79RPS6KB20.68813695
80MAP3K80.68535353
81PLK20.67450494
82TAF10.66991097
83ZAP700.66471083
84PAK20.65643294
85CSNK1G30.64195440
86MAPKAPK30.63775613
87MAP2K60.63075461
88MAP2K30.61456920
89CDK180.60903785
90CDK140.60636331
91LRRK20.59643406
92CDK11A0.56306680
93ARAF0.55449156
94MAP3K100.54770922
95PAK60.54391925
96DYRK30.52765284
97CDK150.52569316
98CSNK2A10.52146179
99PRPF4B0.51691976
100CSNK1A1L0.51399026
101TAOK10.49590915
102STK38L0.48877376
103CHEK10.48856247
104MAP4K10.48532247
105CSNK1G10.47917254
106ERBB30.47428930
107NEK90.44641570
108CDK20.42687397
109CDK40.42145755
110CHEK20.41794415
111CSNK2A20.41277713
112LMTK20.40648680
113FLT30.40505337
114STK40.39909665
115WNK40.39162601
116ZAK0.37643485
117ALK0.36723149
118NEK60.36330324
119STK30.35761267
120GRK50.35180213
121SMG10.34981199
122STK100.34328146
123FGFR10.33584663
124PIK3CG0.32872117
125CSNK1G20.32675868
126CSNK1D0.32675064
127PIM10.31819495
128PRKCG0.31327174
129WNK30.31105141
130MAP3K50.30370320
131PDK20.30331620
132PRKACB0.28958661
133DAPK20.28923146
134TXK0.28743714
135CSNK1E0.28484037
136ATM0.28404576
137MAP2K70.25812168
138CDK10.25112951
139PRKD30.21587912

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.88656930
2DNA replication_Homo sapiens_hsa030304.17959571
3Mismatch repair_Homo sapiens_hsa034303.52801875
4RNA polymerase_Homo sapiens_hsa030203.36821668
5Ribosome_Homo sapiens_hsa030103.22599526
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12726478
7Spliceosome_Homo sapiens_hsa030403.06646193
8Base excision repair_Homo sapiens_hsa034102.86146048
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.84471122
10RNA transport_Homo sapiens_hsa030132.81126017
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66036361
12Nucleotide excision repair_Homo sapiens_hsa034202.47363195
13Pyrimidine metabolism_Homo sapiens_hsa002402.39225063
14Homologous recombination_Homo sapiens_hsa034402.30087545
15Cell cycle_Homo sapiens_hsa041102.15048000
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80509216
17Propanoate metabolism_Homo sapiens_hsa006401.76998126
18Fatty acid elongation_Homo sapiens_hsa000621.75974008
19Parkinsons disease_Homo sapiens_hsa050121.74753838
20One carbon pool by folate_Homo sapiens_hsa006701.69281689
21Oxidative phosphorylation_Homo sapiens_hsa001901.67409522
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63795970
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45968066
24Purine metabolism_Homo sapiens_hsa002301.36639500
25mRNA surveillance pathway_Homo sapiens_hsa030151.35403193
26Steroid biosynthesis_Homo sapiens_hsa001001.34979671
27Basal transcription factors_Homo sapiens_hsa030221.34081426
28RNA degradation_Homo sapiens_hsa030181.33640246
29Huntingtons disease_Homo sapiens_hsa050161.32529558
30Biosynthesis of amino acids_Homo sapiens_hsa012301.31681534
31Epstein-Barr virus infection_Homo sapiens_hsa051691.31383049
32Synaptic vesicle cycle_Homo sapiens_hsa047211.29055025
33Fanconi anemia pathway_Homo sapiens_hsa034601.20782613
34Carbon metabolism_Homo sapiens_hsa012001.20490464
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19280091
36p53 signaling pathway_Homo sapiens_hsa041151.18297319
37Vibrio cholerae infection_Homo sapiens_hsa051101.14225164
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13947817
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.13215703
40Collecting duct acid secretion_Homo sapiens_hsa049661.10865489
41Oocyte meiosis_Homo sapiens_hsa041141.10050867
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09034161
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06235334
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04251462
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.03884763
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02689290
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02356386
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99742993
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98399706
50Pentose phosphate pathway_Homo sapiens_hsa000300.97001833
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96238929
52Fructose and mannose metabolism_Homo sapiens_hsa000510.94403140
53Protein export_Homo sapiens_hsa030600.91496081
54beta-Alanine metabolism_Homo sapiens_hsa004100.89471619
55Thyroid cancer_Homo sapiens_hsa052160.89418590
56Non-homologous end-joining_Homo sapiens_hsa034500.87398079
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85622793
58Galactose metabolism_Homo sapiens_hsa000520.83860122
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83143946
60Alzheimers disease_Homo sapiens_hsa050100.73336368
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72334497
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71206969
63Legionellosis_Homo sapiens_hsa051340.70772748
64Fatty acid degradation_Homo sapiens_hsa000710.70098533
65Fatty acid metabolism_Homo sapiens_hsa012120.69305425
66Peroxisome_Homo sapiens_hsa041460.69003060
67Shigellosis_Homo sapiens_hsa051310.66949682
68Arginine and proline metabolism_Homo sapiens_hsa003300.65166825
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64298687
70Antigen processing and presentation_Homo sapiens_hsa046120.59870061
71HTLV-I infection_Homo sapiens_hsa051660.59760303
72Pyruvate metabolism_Homo sapiens_hsa006200.58768645
73N-Glycan biosynthesis_Homo sapiens_hsa005100.50899458
74Bladder cancer_Homo sapiens_hsa052190.50869691
75Regulation of autophagy_Homo sapiens_hsa041400.49676564
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49464535
77HIF-1 signaling pathway_Homo sapiens_hsa040660.47771153
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47189632
79Herpes simplex infection_Homo sapiens_hsa051680.46617162
80Folate biosynthesis_Homo sapiens_hsa007900.45677437
81Sulfur relay system_Homo sapiens_hsa041220.45550337
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44927547
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43994891
84Viral carcinogenesis_Homo sapiens_hsa052030.43113359
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41975719
86Vitamin B6 metabolism_Homo sapiens_hsa007500.40753852
87Cardiac muscle contraction_Homo sapiens_hsa042600.39762940
88Adherens junction_Homo sapiens_hsa045200.39407570
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38038579
90Type I diabetes mellitus_Homo sapiens_hsa049400.37882800
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.36613866
92Tryptophan metabolism_Homo sapiens_hsa003800.35870623
93Hippo signaling pathway_Homo sapiens_hsa043900.35429072
94Selenocompound metabolism_Homo sapiens_hsa004500.35133585
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.34685312
96Butanoate metabolism_Homo sapiens_hsa006500.33964663
97Lysine degradation_Homo sapiens_hsa003100.32782190
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32602911
99Colorectal cancer_Homo sapiens_hsa052100.31334329
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28171268
101Fat digestion and absorption_Homo sapiens_hsa049750.27333971
102Sulfur metabolism_Homo sapiens_hsa009200.26631740
103Wnt signaling pathway_Homo sapiens_hsa043100.25960373
104Apoptosis_Homo sapiens_hsa042100.23347890
105Chemical carcinogenesis_Homo sapiens_hsa052040.22518619
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.22215139
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21285898
108Phagosome_Homo sapiens_hsa041450.21185667
109Metabolic pathways_Homo sapiens_hsa011000.20953427
110Primary immunodeficiency_Homo sapiens_hsa053400.20231326
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19611120
112Retinol metabolism_Homo sapiens_hsa008300.19460329
113Acute myeloid leukemia_Homo sapiens_hsa052210.17740930
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15965846
115Melanoma_Homo sapiens_hsa052180.15493770
116Endocytosis_Homo sapiens_hsa041440.15061952
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.14820093
118Histidine metabolism_Homo sapiens_hsa003400.13968154
119TGF-beta signaling pathway_Homo sapiens_hsa043500.13610144
120Glutathione metabolism_Homo sapiens_hsa004800.12902377
121Tight junction_Homo sapiens_hsa045300.12698879
122Influenza A_Homo sapiens_hsa051640.11022990
123Hepatitis B_Homo sapiens_hsa051610.10050725
124Caffeine metabolism_Homo sapiens_hsa002320.09743841
125Hedgehog signaling pathway_Homo sapiens_hsa043400.09265659
126Viral myocarditis_Homo sapiens_hsa054160.08574814
127Rheumatoid arthritis_Homo sapiens_hsa053230.08286327
128Measles_Homo sapiens_hsa051620.08094081
129Insulin signaling pathway_Homo sapiens_hsa049100.07706326
130mTOR signaling pathway_Homo sapiens_hsa041500.05278822
131Endometrial cancer_Homo sapiens_hsa052130.04470509
132Basal cell carcinoma_Homo sapiens_hsa052170.04460876
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.03767174

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