ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.78779669
2	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.76952359
3	spinal cord motor neuron differentiation (GO:0021522)	6.67169888
4	adult walking behavior (GO:0007628)	5.94945149
5	postsynaptic membrane organization (GO:0001941)	5.25591242
6	platelet dense granule organization (GO:0060155)	5.17126527
7	auditory behavior (GO:0031223)	5.06898523
8	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	5.03627392
9	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	5.03627392
10	positive regulation of protein homooligomerization (GO:0032464)	4.97651523
11	mechanosensory behavior (GO:0007638)	4.96893305
12	cytidine metabolic process (GO:0046087)	4.93250392
13	cytidine catabolic process (GO:0006216)	4.93250392
14	cytidine deamination (GO:0009972)	4.93250392
15	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.90304330
16	regulation of action potential (GO:0098900)	4.64150787
17	cell differentiation in spinal cord (GO:0021515)	4.61435418
18	nonmotile primary cilium assembly (GO:0035058)	4.47714109
19	negative regulation of nitric-oxide synthase activity (GO:0051001)	4.44497551
20	pyrimidine nucleobase catabolic process (GO:0006208)	4.42734146
21	righting reflex (GO:0060013)	4.42200088
22	positive regulation of filopodium assembly (GO:0051491)	4.40208514
23	DNA deamination (GO:0045006)	4.34911738
24	neuron fate commitment (GO:0048663)	4.33444105
25	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.22772280
26	pre-miRNA processing (GO:0031054)	4.11915734
27	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	4.11077281
28	negative regulation of potassium ion transmembrane transport (GO:1901380)	4.08616705
29	response to pheromone (GO:0019236)	4.08043437
30	response to auditory stimulus (GO:0010996)	4.07370993
31	regulation of dopamine secretion (GO:0014059)	4.04632509
32	post-embryonic morphogenesis (GO:0009886)	4.01969484
33	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.01265562
34	regulation of sarcomere organization (GO:0060297)	3.98643564
35	membrane assembly (GO:0071709)	3.98132415
36	presynaptic membrane assembly (GO:0097105)	3.98078308
37	negative regulation of protein localization to cell surface (GO:2000009)	3.90662527
38	organelle disassembly (GO:1903008)	3.66827705
39	regulation of filopodium assembly (GO:0051489)	3.62455669
40	neurotransmitter-gated ion channel clustering (GO:0072578)	3.59762030
41	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.59611243
42	urinary tract smooth muscle contraction (GO:0014848)	3.54001220
43	layer formation in cerebral cortex (GO:0021819)	3.52524046
44	ear development (GO:0043583)	3.51272480
45	nucleobase catabolic process (GO:0046113)	3.50368417
46	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.48869034
47	RNA localization (GO:0006403)	3.45142696
48	presynaptic membrane organization (GO:0097090)	3.40689163
49	regulation of cilium movement (GO:0003352)	3.39985707
50	positive regulation of mitochondrial membrane permeability (GO:0035794)	3.33244922
51	vocalization behavior (GO:0071625)	3.30909787
52	ncRNA catabolic process (GO:0034661)	3.28010927
53	cochlea development (GO:0090102)	3.20212363
54	RNA destabilization (GO:0050779)	3.17115738
55	ribonucleoprotein complex disassembly (GO:0032988)	3.16480339
56	developmental pigmentation (GO:0048066)	3.15192596
57	cerebral cortex radially oriented cell migration (GO:0021799)	3.13596769
58	regulation of protein homooligomerization (GO:0032462)	3.12790892
59	neuronal action potential (GO:0019228)	3.12615022
60	neuron cell-cell adhesion (GO:0007158)	3.05618934
61	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	3.03843570
62	single strand break repair (GO:0000012)	3.02307920
63	fucose catabolic process (GO:0019317)	2.96694453
64	L-fucose metabolic process (GO:0042354)	2.96694453
65	L-fucose catabolic process (GO:0042355)	2.96694453
66	action potential (GO:0001508)	2.92761672
67	synaptic transmission, cholinergic (GO:0007271)	2.92447517
68	positive regulation of cell fate commitment (GO:0010455)	2.90342165
69	N-acetylneuraminate metabolic process (GO:0006054)	2.89027939
70	membrane depolarization during action potential (GO:0086010)	2.82341047
71	detection of light stimulus involved in sensory perception (GO:0050962)	2.80856127
72	detection of light stimulus involved in visual perception (GO:0050908)	2.80856127
73	DNA demethylation (GO:0080111)	2.80680676
74	metanephric tubule development (GO:0072170)	2.79605664
75	metanephric nephron tubule development (GO:0072234)	2.79605664
76	photoreceptor cell development (GO:0042461)	2.78415912
77	plasma membrane repair (GO:0001778)	2.78323995
78	retinal cone cell development (GO:0046549)	2.75912928
79	renal tubule development (GO:0061326)	2.75315710
80	water-soluble vitamin biosynthetic process (GO:0042364)	2.75034560
81	histone mRNA catabolic process (GO:0071044)	2.69556961
82	positive regulation of neurotransmitter secretion (GO:0001956)	2.68991052
83	regulation of membrane repolarization (GO:0060306)	2.68985354
84	adult behavior (GO:0030534)	2.64711176
85	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.62760214
86	regulation of skeletal muscle contraction (GO:0014819)	2.61728866
87	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	2.61695834
88	response to gravity (GO:0009629)	2.61011447
89	positive regulation of action potential (GO:0045760)	2.60503907
90	adult locomotory behavior (GO:0008344)	2.60179360
91	positive regulation of neurotransmitter transport (GO:0051590)	2.59908054
92	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.58623892
93	regulation of acrosome reaction (GO:0060046)	2.56654353
94	negative regulation of Rho protein signal transduction (GO:0035024)	2.56568619
95	reflex (GO:0060004)	2.56078777
96	regulation of collateral sprouting (GO:0048670)	2.55835408
97	establishment of protein localization to Golgi (GO:0072600)	2.54979240
98	eye photoreceptor cell development (GO:0042462)	2.51357079
99	anterograde synaptic vesicle transport (GO:0048490)	2.50395647
100	regulation of synapse maturation (GO:0090128)	2.49728636

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.84262721
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.66781608
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.59594083
4	VDR_22108803_ChIP-Seq_LS180_Human	3.41204265
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.24936324
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.92944551
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.70707823
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.54131308
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.51831160
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.32744018
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.21682218
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19170615
13	EWS_26573619_Chip-Seq_HEK293_Human	2.15313187
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10724098
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05477113
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.00196061
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.98123520
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98112209
19	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.95420537
20	P300_19829295_ChIP-Seq_ESCs_Human	1.92097946
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.89939655
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.89109438
23	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.87876297
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.81937789
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.75855865
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75144655
27	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.74594122
28	FUS_26573619_Chip-Seq_HEK293_Human	1.74101214
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.72972835
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72441781
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.70325790
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66536214
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.64876653
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63678212
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.62947911
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62947911
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56346370
38	STAT3_23295773_ChIP-Seq_U87_Human	1.48999381
39	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.47330973
40	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.46534779
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46157340
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45427951
43	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.45236545
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39090957
45	HTT_18923047_ChIP-ChIP_STHdh_Human	1.38338055
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36039336
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35098917
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34332991
49	TCF4_23295773_ChIP-Seq_U87_Human	1.31954057
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31704181
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31521391
52	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.29360660
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29129477
54	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.28580247
55	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.28580247
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26358571
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24251628
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.22698810
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22644305
60	AR_25329375_ChIP-Seq_VCAP_Human	1.21142223
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.20744706
62	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18490939
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.17575607
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14545836
65	MYC_19829295_ChIP-Seq_ESCs_Human	1.13544541
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13502557
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13480698
68	RXR_22108803_ChIP-Seq_LS180_Human	1.12811953
69	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.11510473
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11352406
71	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.10012977
72	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.09965459
73	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.08931485
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08785429
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06224584
76	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.05409795
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01906811
78	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00699709
79	CBP_20019798_ChIP-Seq_JUKART_Human	1.00672115
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00672115
81	KDM2B_26808549_Chip-Seq_REH_Human	0.99965668
82	AR_21572438_ChIP-Seq_LNCaP_Human	0.99468735
83	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99396135
84	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98503174
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.97111054
86	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.96337787
87	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.96254261
88	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.94656045
89	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94369848
90	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93721653
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93582110
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92954995
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92588841
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91147750
95	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.90654186
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.90501558
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.90167021
98	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.89195289
99	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89185891
100	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.88848812

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	4.22594029
2	MP0002837_dystrophic_cardiac_calcinosis	3.93586241
3	MP0006292_abnormal_olfactory_placode	3.62512997
4	MP0003787_abnormal_imprinting	3.57638994
5	MP0003880_abnormal_central_pattern	3.39537375
6	MP0002736_abnormal_nociception_after	2.99248140
7	MP0005394_taste/olfaction_phenotype	2.81738240
8	MP0005499_abnormal_olfactory_system	2.81738240
9	MP0008789_abnormal_olfactory_epithelium	2.81453381
10	MP0001968_abnormal_touch/_nociception	2.75055618
11	MP0003646_muscle_fatigue	2.61252049
12	MP0008877_abnormal_DNA_methylation	2.55157901
13	MP0002734_abnormal_mechanical_nocicepti	2.44418120
14	MP0001984_abnormal_olfaction	2.19265542
15	MP0002272_abnormal_nervous_system	2.16268622
16	MP0003950_abnormal_plasma_membrane	2.13113353
17	MP0002163_abnormal_gland_morphology	2.13082847
18	MP0005551_abnormal_eye_electrophysiolog	2.12477103
19	MP0002876_abnormal_thyroid_physiology	2.05031090
20	MP0002102_abnormal_ear_morphology	2.02291668
21	MP0002909_abnormal_adrenal_gland	2.00502644
22	MP0001529_abnormal_vocalization	1.99969655
23	MP0003011_delayed_dark_adaptation	1.98646069
24	MP0002653_abnormal_ependyma_morphology	1.92436046
25	MP0002751_abnormal_autonomic_nervous	1.84716262
26	MP0000372_irregular_coat_pigmentation	1.84527028
27	MP0006276_abnormal_autonomic_nervous	1.78727081
28	MP0009046_muscle_twitch	1.77358406
29	MP0003635_abnormal_synaptic_transmissio	1.77336380
30	MP0000427_abnormal_hair_cycle	1.70444511
31	MP0009745_abnormal_behavioral_response	1.60708793
32	MP0004142_abnormal_muscle_tone	1.48777405
33	MP0002234_abnormal_pharynx_morphology	1.48195652
34	MP0002735_abnormal_chemical_nociception	1.43342046
35	MP0005646_abnormal_pituitary_gland	1.41053622
36	MP0005670_abnormal_white_adipose	1.38142984
37	MP0005379_endocrine/exocrine_gland_phen	1.37922226
38	MP0005253_abnormal_eye_physiology	1.37765274
39	MP0005423_abnormal_somatic_nervous	1.34209941
40	MP0003890_abnormal_embryonic-extraembry	1.30166987
41	MP0001970_abnormal_pain_threshold	1.27744543
42	MP0010386_abnormal_urinary_bladder	1.23622193
43	MP0001853_heart_inflammation	1.22941219
44	MP0002067_abnormal_sensory_capabilities	1.21738792
45	MP0002572_abnormal_emotion/affect_behav	1.21491157
46	MP0006072_abnormal_retinal_apoptosis	1.21349607
47	MP0008995_early_reproductive_senescence	1.21276314
48	MP0002557_abnormal_social/conspecific_i	1.17842811
49	MP0002822_catalepsy	1.17714193
50	MP0001485_abnormal_pinna_reflex	1.17095751
51	MP0001348_abnormal_lacrimal_gland	1.16482547
52	MP0001919_abnormal_reproductive_system	1.16429357
53	MP0002063_abnormal_learning/memory/cond	1.16127757
54	MP0002064_seizures	1.15274643
55	MP0004130_abnormal_muscle_cell	1.08431364
56	MP0001486_abnormal_startle_reflex	1.08327649
57	MP0008872_abnormal_physiological_respon	1.08139537
58	MP0001765_abnormal_ion_homeostasis	1.07592872
59	MP0005389_reproductive_system_phenotype	1.04065316
60	MP0001440_abnormal_grooming_behavior	1.03783744
61	MP0005195_abnormal_posterior_eye	1.01460748
62	MP0000749_muscle_degeneration	1.01190236
63	MP0005386_behavior/neurological_phenoty	0.99370995
64	MP0004924_abnormal_behavior	0.99370995
65	MP0000778_abnormal_nervous_system	0.97672539
66	MP0002938_white_spotting	0.93356685
67	MP0003786_premature_aging	0.93327855
68	MP0008775_abnormal_heart_ventricle	0.91243937
69	MP0004270_analgesia	0.91172297
70	MP0003879_abnormal_hair_cell	0.88922509
71	MP0003045_fibrosis	0.87965782
72	MP0008875_abnormal_xenobiotic_pharmacok	0.87168850
73	MP0003122_maternal_imprinting	0.86839987
74	MP0000631_abnormal_neuroendocrine_gland	0.84354803
75	MP0004043_abnormal_pH_regulation	0.82977808
76	MP0003633_abnormal_nervous_system	0.82228790
77	MP0004885_abnormal_endolymph	0.82013047
78	MP0002733_abnormal_thermal_nociception	0.81999602
79	MP0003121_genomic_imprinting	0.77312512
80	MP0002752_abnormal_somatic_nervous	0.75847171
81	MP0001501_abnormal_sleep_pattern	0.75547876
82	MP0001986_abnormal_taste_sensitivity	0.74921693
83	MP0002210_abnormal_sex_determination	0.74397219
84	MP0002882_abnormal_neuron_morphology	0.74058919
85	MP0001502_abnormal_circadian_rhythm	0.71601780
86	MP0000230_abnormal_systemic_arterial	0.71286938
87	MP0003195_calcinosis	0.70666955
88	MP0004145_abnormal_muscle_electrophysio	0.67069812
89	MP0001188_hyperpigmentation	0.66409623
90	MP0005391_vision/eye_phenotype	0.64553286
91	MP0002066_abnormal_motor_capabilities/c	0.64087565
92	MP0004085_abnormal_heartbeat	0.63803430
93	MP0004147_increased_porphyrin_level	0.62711849
94	MP0000049_abnormal_middle_ear	0.61633151
95	MP0001119_abnormal_female_reproductive	0.59091798
96	MP0005410_abnormal_fertilization	0.58300236
97	MP0004185_abnormal_adipocyte_glucose	0.58201094
98	MP0003136_yellow_coat_color	0.56807596
99	MP0000647_abnormal_sebaceous_gland	0.54600788
100	MP0002184_abnormal_innervation	0.54548577

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	5.04366695
2	Agitation (HP:0000713)	4.57355128
3	Abnormal drinking behavior (HP:0030082)	4.55864859
4	Polydipsia (HP:0001959)	4.55864859
5	Abnormality of the labia minora (HP:0012880)	3.70350326
6	Calf muscle hypertrophy (HP:0008981)	3.67727849
7	Medial flaring of the eyebrow (HP:0010747)	3.43349107
8	Abnormality of the renal cortex (HP:0011035)	3.36200793
9	Gait imbalance (HP:0002141)	3.16730527
10	Broad-based gait (HP:0002136)	3.16135311
11	Muscle hypertrophy of the lower extremities (HP:0008968)	3.14366281
12	Hyperphosphatemia (HP:0002905)	3.05134011
13	Aplastic anemia (HP:0001915)	2.98026442
14	Polyuria (HP:0000103)	2.94821740
15	Hemiplegia (HP:0002301)	2.92095698
16	Increased serum pyruvate (HP:0003542)	2.90479926
17	Drooling (HP:0002307)	2.85937271
18	Abolished electroretinogram (ERG) (HP:0000550)	2.84067704
19	Hyperinsulinemic hypoglycemia (HP:0000825)	2.83170298
20	Congenital primary aphakia (HP:0007707)	2.82758832
21	Nephronophthisis (HP:0000090)	2.79421511
22	Renal cortical cysts (HP:0000803)	2.78861892
23	Limb dystonia (HP:0002451)	2.77018875
24	Nephrogenic diabetes insipidus (HP:0009806)	2.72292295
25	Severe visual impairment (HP:0001141)	2.70870977
26	Abnormality of the metopic suture (HP:0005556)	2.66463498
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.62821694
28	True hermaphroditism (HP:0010459)	2.61407489
29	Excessive salivation (HP:0003781)	2.60431245
30	Pancreatic cysts (HP:0001737)	2.58696798
31	Tubular atrophy (HP:0000092)	2.58330457
32	Decreased circulating renin level (HP:0003351)	2.57896139
33	Male infertility (HP:0003251)	2.56990803
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53275903
35	Left ventricular hypertrophy (HP:0001712)	2.52401940
36	Pancreatic islet-cell hyperplasia (HP:0004510)	2.51683165
37	Molar tooth sign on MRI (HP:0002419)	2.49328167
38	Abnormality of midbrain morphology (HP:0002418)	2.49328167
39	Epileptic encephalopathy (HP:0200134)	2.49008928
40	Rimmed vacuoles (HP:0003805)	2.48654517
41	Polyphagia (HP:0002591)	2.47321152
42	Restlessness (HP:0000711)	2.46200483
43	Prolonged QT interval (HP:0001657)	2.44889250
44	Abnormal urine output (HP:0012590)	2.44434542
45	Lipid accumulation in hepatocytes (HP:0006561)	2.42965989
46	Gaze-evoked nystagmus (HP:0000640)	2.38054180
47	Mitochondrial inheritance (HP:0001427)	2.34660412
48	Palpebral edema (HP:0100540)	2.34595210
49	Carpal bone hypoplasia (HP:0001498)	2.32565298
50	Large for gestational age (HP:0001520)	2.32255533
51	Focal seizures (HP:0007359)	2.30370339
52	Abnormality of glycolysis (HP:0004366)	2.28088606
53	Hypoplastic nipples (HP:0002557)	2.27365695
54	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.26035933
55	Amblyopia (HP:0000646)	2.25061307
56	Keratoconus (HP:0000563)	2.23520615
57	Increased corneal curvature (HP:0100692)	2.23520615
58	Genital tract atresia (HP:0001827)	2.20746065
59	Abnormality of the renal medulla (HP:0100957)	2.18701249
60	Ketoacidosis (HP:0001993)	2.18574975
61	Chronic hepatic failure (HP:0100626)	2.15203312
62	Pancreatic fibrosis (HP:0100732)	2.13788556
63	Vaginal atresia (HP:0000148)	2.09997719
64	Prominent metopic ridge (HP:0005487)	2.05874608
65	Broad ribs (HP:0000885)	2.04642760
66	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.02289749
67	Hypoalbuminemia (HP:0003073)	2.01427224
68	Abnormal albumin level (HP:0012116)	2.01427224
69	Abnormality of urine glucose concentration (HP:0011016)	1.99622673
70	Glycosuria (HP:0003076)	1.99622673
71	Increased hepatocellular lipid droplets (HP:0006565)	1.98662661
72	Bony spicule pigmentary retinopathy (HP:0007737)	1.98187332
73	Hypomagnesemia (HP:0002917)	1.97194362
74	Poor coordination (HP:0002370)	1.95245418
75	Pendular nystagmus (HP:0012043)	1.94448008
76	Abnormality of renal excretion (HP:0011036)	1.93142617
77	Hypoplasia of the thymus (HP:0000778)	1.91296079
78	Abnormality of the pubic bones (HP:0003172)	1.90454503
79	Hepatocellular necrosis (HP:0001404)	1.88959232
80	Hepatoblastoma (HP:0002884)	1.86883011
81	Hypoproteinemia (HP:0003075)	1.84125530
82	Poor suck (HP:0002033)	1.81765913
83	Ketosis (HP:0001946)	1.79791218
84	Partial agenesis of the corpus callosum (HP:0001338)	1.79251503
85	Hypoplasia of the pons (HP:0012110)	1.77162153
86	Renal Fanconi syndrome (HP:0001994)	1.76048486
87	Increased density of long bones (HP:0006392)	1.75632214
88	Exercise-induced muscle cramps (HP:0003710)	1.73912557
89	Subaortic stenosis (HP:0001682)	1.72704666
90	Abnormality of the left ventricular outflow tract (HP:0011103)	1.72704666
91	Hemiparesis (HP:0001269)	1.72469525
92	Enlarged penis (HP:0000040)	1.70951130
93	Attenuation of retinal blood vessels (HP:0007843)	1.68887165
94	Acute necrotizing encephalopathy (HP:0006965)	1.66667660
95	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.66130967
96	Abnormality of the pons (HP:0007361)	1.64351400
97	Congenital sensorineural hearing impairment (HP:0008527)	1.64199220
98	3-Methylglutaconic aciduria (HP:0003535)	1.63730271
99	Hyperalaninemia (HP:0003348)	1.63726290
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.63726290

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	6.91105892
2	FRK	3.80286553
3	EPHA3	3.46752330
4	MAPK13	3.07010608
5	MAP3K4	2.61772001
6	CCNB1	2.52870221
7	TAF1	2.47285451
8	MAPKAPK5	2.39756262
9	MUSK	2.33091314
10	NTRK3	2.13627833
11	MAPKAPK3	1.94329882
12	DYRK2	1.92645987
13	MAP2K7	1.84875734
14	BRSK1	1.82287094
15	ACVR1B	1.73446946
16	TXK	1.72196461
17	EEF2K	1.69401288
18	WNK4	1.64508369
19	NTRK2	1.62219679
20	CAMKK1	1.59561906
21	MARK1	1.59474612
22	BMPR1B	1.52542322
23	SGK494	1.47741723
24	SGK223	1.47741723
25	SGK2	1.33163244
26	DAPK2	1.27733344
27	PRKD3	1.24376098
28	STK39	1.24250869
29	PAK3	1.23564322
30	CAMKK2	1.20548395
31	WNK3	1.15661933
32	TLK1	1.11480386
33	EIF2AK3	1.04211228
34	CDK8	0.98986644
35	SGK3	0.96963423
36	SRPK1	0.91249187
37	RPS6KB2	0.85257976
38	PLK2	0.83934467
39	TYRO3	0.82863163
40	STK38L	0.82329877
41	EPHA4	0.82093389
42	CSNK1G1	0.81914474
43	PINK1	0.81523467
44	PRKCI	0.79738931
45	CAMK2D	0.78605364
46	NUAK1	0.78305333
47	TRPM7	0.77861394
48	MAPK12	0.74178572
49	AKT3	0.73955530
50	PRKCG	0.70710582
51	ADRBK2	0.70627477
52	PKN1	0.69974970
53	RPS6KA2	0.67455934
54	TNK2	0.65952823
55	GRK1	0.65351469
56	ITK	0.64820409
57	STK11	0.63561544
58	MAP4K2	0.63303700
59	CSNK1G3	0.62931734
60	NLK	0.61924487
61	PTK2B	0.61855516
62	PRKACA	0.59445935
63	OXSR1	0.59324772
64	INSRR	0.58353754
65	PIK3CA	0.57998254
66	BRSK2	0.57766419
67	TAOK3	0.56397005
68	CAMK2B	0.55328303
69	CSNK1G2	0.54904507
70	FES	0.54499072
71	DMPK	0.53926677
72	PIK3CG	0.53150698
73	SGK1	0.50212913
74	PHKG1	0.49846273
75	PHKG2	0.49846273
76	PRKCE	0.47833243
77	ERBB3	0.46524078
78	CHEK2	0.45834348
79	HIPK2	0.45411925
80	TNIK	0.44620362
81	PLK4	0.44449501
82	PRKACB	0.43027806
83	PRKCQ	0.42845900
84	KSR1	0.41875876
85	PAK6	0.41338787
86	CDK5	0.41176884
87	PRKCH	0.39322439
88	BUB1	0.38232264
89	CSNK1A1L	0.36562788
90	MAP3K11	0.34426422
91	VRK1	0.33318796
92	STK24	0.33160590
93	CSNK1A1	0.32066883
94	EIF2AK2	0.31287942
95	MAP2K4	0.31140658
96	CDK18	0.29774999
97	CDK15	0.28871617
98	PRKCA	0.28527963
99	BCKDK	0.26459005
100	CAMK2A	0.25746514

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.89772104
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.48476788
3	Nicotine addiction_Homo sapiens_hsa05033	3.43878589
4	Regulation of autophagy_Homo sapiens_hsa04140	3.09881247
5	Sulfur metabolism_Homo sapiens_hsa00920	2.94331557
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.80844251
7	Oxidative phosphorylation_Homo sapiens_hsa00190	1.97982513
8	RNA polymerase_Homo sapiens_hsa03020	1.92751127
9	Parkinsons disease_Homo sapiens_hsa05012	1.80528330
10	ABC transporters_Homo sapiens_hsa02010	1.74799861
11	Butanoate metabolism_Homo sapiens_hsa00650	1.72352208
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72002303
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.70398701
14	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.69892114
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67598481
16	Insulin secretion_Homo sapiens_hsa04911	1.61194525
17	Circadian entrainment_Homo sapiens_hsa04713	1.60244209
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53145334
19	Propanoate metabolism_Homo sapiens_hsa00640	1.53003094
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50226100
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.49005828
22	Morphine addiction_Homo sapiens_hsa05032	1.48183258
23	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.47213663
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.46266196
25	Phototransduction_Homo sapiens_hsa04744	1.44973389
26	Caffeine metabolism_Homo sapiens_hsa00232	1.43920564
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42154648
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.37788381
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36526190
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.30886202
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24286373
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.22424884
33	Glycerolipid metabolism_Homo sapiens_hsa00561	1.21647026
34	GABAergic synapse_Homo sapiens_hsa04727	1.19785678
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.18974324
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.18876932
37	Basal transcription factors_Homo sapiens_hsa03022	1.18354661
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.16904902
39	Olfactory transduction_Homo sapiens_hsa04740	1.15825336
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.15693499
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15332598
42	Serotonergic synapse_Homo sapiens_hsa04726	1.14961494
43	Amphetamine addiction_Homo sapiens_hsa05031	1.14926885
44	Alzheimers disease_Homo sapiens_hsa05010	1.12903179
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.10131676
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07492871
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.06938353
48	Huntingtons disease_Homo sapiens_hsa05016	1.05381195
49	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.04309920
50	Tryptophan metabolism_Homo sapiens_hsa00380	1.01789117
51	RNA degradation_Homo sapiens_hsa03018	0.99927114
52	Taste transduction_Homo sapiens_hsa04742	0.99790030
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.99448210
54	Pancreatic secretion_Homo sapiens_hsa04972	0.96919080
55	Fatty acid elongation_Homo sapiens_hsa00062	0.95878401
56	Cocaine addiction_Homo sapiens_hsa05030	0.95540655
57	Type II diabetes mellitus_Homo sapiens_hsa04930	0.89764130
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85518068
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.82769741
60	Proteasome_Homo sapiens_hsa03050	0.81312067
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.79306862
62	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.74936290
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.74216067
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73681311
65	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.70410656
66	Retinol metabolism_Homo sapiens_hsa00830	0.70131179
67	Axon guidance_Homo sapiens_hsa04360	0.68805887
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62676236
69	cAMP signaling pathway_Homo sapiens_hsa04024	0.61391840
70	Peroxisome_Homo sapiens_hsa04146	0.60860413
71	Cholinergic synapse_Homo sapiens_hsa04725	0.59432125
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.58394491
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57067215
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55611961
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54038009
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.52585136
77	Circadian rhythm_Homo sapiens_hsa04710	0.51830141
78	Fatty acid degradation_Homo sapiens_hsa00071	0.51781888
79	Mineral absorption_Homo sapiens_hsa04978	0.51473722
80	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.49894180
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49220320
82	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.48199421
83	Histidine metabolism_Homo sapiens_hsa00340	0.47955009
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.47580296
85	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.46795819
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.46339152
87	Metabolic pathways_Homo sapiens_hsa01100	0.46311516
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.44902096
89	Salivary secretion_Homo sapiens_hsa04970	0.43377974
90	Homologous recombination_Homo sapiens_hsa03440	0.42828768
91	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.42202504
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39527687
93	Primary immunodeficiency_Homo sapiens_hsa05340	0.33876409
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30021307
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28868653
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28341425
97	Renin secretion_Homo sapiens_hsa04924	0.28021161
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26547965
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26498739
100	Type I diabetes mellitus_Homo sapiens_hsa04940	0.25952361

UBE2V1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »