ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.15312022
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.61199041
3	ATP synthesis coupled proton transport (GO:0015986)	5.61199041
4	dopamine biosynthetic process (GO:0042416)	5.25157139
5	alkaloid metabolic process (GO:0009820)	5.03983002
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.70636925
7	indolalkylamine metabolic process (GO:0006586)	4.67937680
8	behavioral response to nicotine (GO:0035095)	4.60800128
9	sequestering of actin monomers (GO:0042989)	4.31306741
10	respiratory electron transport chain (GO:0022904)	4.29854764
11	electron transport chain (GO:0022900)	4.26442644
12	DNA deamination (GO:0045006)	4.21087661
13	cellular ketone body metabolic process (GO:0046950)	4.20094009
14	toxin metabolic process (GO:0009404)	3.84472529
15	platelet dense granule organization (GO:0060155)	3.79574551
16	ketone body metabolic process (GO:1902224)	3.70458779
17	behavioral response to ethanol (GO:0048149)	3.55729724
18	catecholamine biosynthetic process (GO:0042423)	3.52850007
19	catechol-containing compound biosynthetic process (GO:0009713)	3.52850007
20	hydrogen ion transmembrane transport (GO:1902600)	3.48937518
21	protein-cofactor linkage (GO:0018065)	3.48449014
22	urinary tract smooth muscle contraction (GO:0014848)	3.47216111
23	artery smooth muscle contraction (GO:0014824)	3.37806810
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.36064792
25	hydrogen transport (GO:0006818)	3.33393414
26	response to insecticide (GO:0017085)	3.31157318
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30719986
28	L-fucose catabolic process (GO:0042355)	3.30019933
29	fucose catabolic process (GO:0019317)	3.30019933
30	L-fucose metabolic process (GO:0042354)	3.30019933
31	indole-containing compound catabolic process (GO:0042436)	3.27982415
32	indolalkylamine catabolic process (GO:0046218)	3.27982415
33	tryptophan catabolic process (GO:0006569)	3.27982415
34	anterograde synaptic vesicle transport (GO:0048490)	3.27456323
35	proton transport (GO:0015992)	3.26430040
36	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.26065308
37	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.22092439
38	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.21947531
39	indole-containing compound metabolic process (GO:0042430)	3.19512804
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.15862072
41	NADH dehydrogenase complex assembly (GO:0010257)	3.15862072
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.15862072
43	protein complex biogenesis (GO:0070271)	3.15484039
44	serotonin receptor signaling pathway (GO:0007210)	3.02559817
45	tryptophan metabolic process (GO:0006568)	3.02404449
46	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.01474360
47	mechanosensory behavior (GO:0007638)	3.00395542
48	cornea development in camera-type eye (GO:0061303)	3.00341050
49	replication fork processing (GO:0031297)	2.96698670
50	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.92933589
51	ATP biosynthetic process (GO:0006754)	2.92214583
52	anterograde axon cargo transport (GO:0008089)	2.91050286
53	tonic smooth muscle contraction (GO:0014820)	2.89188832
54	serotonin metabolic process (GO:0042428)	2.89105304
55	auditory behavior (GO:0031223)	2.87560979
56	kynurenine metabolic process (GO:0070189)	2.86474499
57	tachykinin receptor signaling pathway (GO:0007217)	2.84156084
58	primary amino compound metabolic process (GO:1901160)	2.82202528
59	peristalsis (GO:0030432)	2.81848612
60	water-soluble vitamin biosynthetic process (GO:0042364)	2.81130538
61	ubiquinone biosynthetic process (GO:0006744)	2.80049226
62	S-adenosylmethionine metabolic process (GO:0046500)	2.79602959
63	neural tube formation (GO:0001841)	2.79493225
64	proteasome assembly (GO:0043248)	2.79470732
65	inner ear receptor stereocilium organization (GO:0060122)	2.78604671
66	amino acid salvage (GO:0043102)	2.77849298
67	L-methionine salvage (GO:0071267)	2.77849298
68	L-methionine biosynthetic process (GO:0071265)	2.77849298
69	regulation of dopamine secretion (GO:0014059)	2.74064952
70	cellular response to interferon-beta (GO:0035458)	2.71861996
71	transmission of nerve impulse (GO:0019226)	2.71131022
72	presynaptic membrane assembly (GO:0097105)	2.70741337
73	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.70115278
74	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.68800620
75	ubiquinone metabolic process (GO:0006743)	2.68090270
76	positive regulation by host of viral transcription (GO:0043923)	2.67383131
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.67357929
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.64678163
79	postsynaptic membrane organization (GO:0001941)	2.64670621
80	regulation of triglyceride catabolic process (GO:0010896)	2.64192116
81	protein neddylation (GO:0045116)	2.63912408
82	autophagic vacuole fusion (GO:0000046)	2.63672616
83	negative regulation of mast cell activation (GO:0033004)	2.58481332
84	multicellular organismal aging (GO:0010259)	2.57761721
85	response to interferon-beta (GO:0035456)	2.56550039
86	regulation of phospholipid biosynthetic process (GO:0071071)	2.56356807
87	neuron fate determination (GO:0048664)	2.55798415
88	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.55663853
89	sleep (GO:0030431)	2.53674552
90	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.52261823
91	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.48223010
92	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.45954551
93	short-term memory (GO:0007614)	2.45598273
94	gamma-aminobutyric acid transport (GO:0015812)	2.45328426
95	detection of light stimulus involved in sensory perception (GO:0050962)	2.43693370
96	detection of light stimulus involved in visual perception (GO:0050908)	2.43693370
97	copper ion transport (GO:0006825)	2.43532313
98	organelle membrane fusion (GO:0090174)	2.42247714
99	synaptic transmission, dopaminergic (GO:0001963)	2.41283259
100	RNA destabilization (GO:0050779)	2.39039294

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.90086908
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.24642734
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.99162000
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94589967
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.83611518
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.83571603
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67059261
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58842273
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.54484402
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.50006953
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28929480
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.26587790
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.26004671
14	EWS_26573619_Chip-Seq_HEK293_Human	2.17324366
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.13960678
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09159239
17	BCAT_22108803_ChIP-Seq_LS180_Human	2.08272508
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.03144487
19	FUS_26573619_Chip-Seq_HEK293_Human	2.02950493
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02095530
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.86701207
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84839202
23	P300_19829295_ChIP-Seq_ESCs_Human	1.81544525
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.77346833
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.76503934
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74599403
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.72278966
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.67839858
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66137605
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.65813600
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65573507
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65144704
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.65018769
34	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.64558807
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.64066532
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57456470
37	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.56465730
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49439795
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.48772336
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.48772336
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47718541
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46561924
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44880692
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40814438
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.40750960
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.39318417
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39209170
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.38003190
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38003190
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.37298862
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34967419
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32858617
53	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.32326151
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31282411
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29628978
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29264032
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24997223
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24130213
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23128515
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23128515
61	TCF4_23295773_ChIP-Seq_U87_Human	1.22679214
62	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22340006
63	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.22155760
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22145383
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20434430
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20124325
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19925202
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19842730
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.19312611
70	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18832841
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18188684
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18188684
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16554590
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14130758
75	AR_25329375_ChIP-Seq_VCAP_Human	1.11193904
76	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.10500087
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.10364978
78	STAT3_23295773_ChIP-Seq_U87_Human	1.10136462
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09494256
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07995568
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.06973673
82	VDR_23849224_ChIP-Seq_CD4+_Human	1.06593594
83	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05971160
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05815441
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05648150
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04249414
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02532675
88	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.01718642
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01704109
90	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.00994399
91	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00639285
92	NCOR_22424771_ChIP-Seq_293T_Human	1.00579438
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00104711
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99798188
95	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98899911
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.98636802
97	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.98309838
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97831049
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97802098
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97595429

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	3.27096607
2	MP0005408_hypopigmentation	2.98423239
3	MP0000569_abnormal_digit_pigmentation	2.92911542
4	MP0009379_abnormal_foot_pigmentation	2.74553295
5	MP0005645_abnormal_hypothalamus_physiol	2.72855594
6	MP0002009_preneoplasia	2.64525950
7	MP0006072_abnormal_retinal_apoptosis	2.48791640
8	MP0001529_abnormal_vocalization	2.36388463
9	MP0002163_abnormal_gland_morphology	2.30561058
10	MP0005084_abnormal_gallbladder_morpholo	2.28761543
11	MP0003880_abnormal_central_pattern	2.28695502
12	MP0004142_abnormal_muscle_tone	2.22404284
13	MP0004145_abnormal_muscle_electrophysio	2.09926923
14	MP0008875_abnormal_xenobiotic_pharmacok	2.08362316
15	MP0005367_renal/urinary_system_phenotyp	2.06362457
16	MP0000516_abnormal_urinary_system	2.06362457
17	MP0002166_altered_tumor_susceptibility	2.02792520
18	MP0005646_abnormal_pituitary_gland	1.93019532
19	MP0002876_abnormal_thyroid_physiology	1.91333977
20	MP0001968_abnormal_touch/_nociception	1.87132114
21	MP0002138_abnormal_hepatobiliary_system	1.86041346
22	MP0008872_abnormal_physiological_respon	1.77764535
23	MP0001986_abnormal_taste_sensitivity	1.76606783
24	MP0003787_abnormal_imprinting	1.75389634
25	MP0004742_abnormal_vestibular_system	1.74082904
26	MP0009053_abnormal_anal_canal	1.72439356
27	MP0005423_abnormal_somatic_nervous	1.71374324
28	MP0002822_catalepsy	1.71201489
29	MP0002736_abnormal_nociception_after	1.68188481
30	MP0002928_abnormal_bile_duct	1.61312346
31	MP0009745_abnormal_behavioral_response	1.59365395
32	MP0008877_abnormal_DNA_methylation	1.59200183
33	MP0002102_abnormal_ear_morphology	1.58681927
34	MP0001905_abnormal_dopamine_level	1.55534978
35	MP0000427_abnormal_hair_cycle	1.55464019
36	MP0002938_white_spotting	1.55234143
37	MP0005075_abnormal_melanosome_morpholog	1.55105995
38	MP0002909_abnormal_adrenal_gland	1.54094942
39	MP0004147_increased_porphyrin_level	1.52564129
40	MP0006276_abnormal_autonomic_nervous	1.49377438
41	MP0000631_abnormal_neuroendocrine_gland	1.48551605
42	MP0003718_maternal_effect	1.44909482
43	MP0005551_abnormal_eye_electrophysiolog	1.41571345
44	MP0006292_abnormal_olfactory_placode	1.40549501
45	MP0005379_endocrine/exocrine_gland_phen	1.39884149
46	MP0003195_calcinosis	1.37286257
47	MP0002006_tumorigenesis	1.31941487
48	MP0002282_abnormal_trachea_morphology	1.29363533
49	MP0002272_abnormal_nervous_system	1.28307640
50	MP0005253_abnormal_eye_physiology	1.26560365
51	MP0009046_muscle_twitch	1.18462628
52	MP0001835_abnormal_antigen_presentation	1.14096719
53	MP0009697_abnormal_copulation	1.09245041
54	MP0001764_abnormal_homeostasis	1.08469796
55	MP0001177_atelectasis	1.06729413
56	MP0001486_abnormal_startle_reflex	1.05701245
57	MP0002735_abnormal_chemical_nociception	1.05370373
58	MP0009764_decreased_sensitivity_to	1.04973578
59	MP0002837_dystrophic_cardiac_calcinosis	1.04113466
60	MP0001485_abnormal_pinna_reflex	1.03944846
61	MP0003137_abnormal_impulse_conducting	1.03738030
62	MP0005636_abnormal_mineral_homeostasis	1.03570476
63	MP0004133_heterotaxia	1.01735392
64	MP0005671_abnormal_response_to	0.99732245
65	MP0000639_abnormal_adrenal_gland	0.94922578
66	MP0005386_behavior/neurological_phenoty	0.94585473
67	MP0004924_abnormal_behavior	0.94585473
68	MP0003011_delayed_dark_adaptation	0.94060270
69	MP0002064_seizures	0.93752943
70	MP0003045_fibrosis	0.90231984
71	MP0001440_abnormal_grooming_behavior	0.89309678
72	MP0002234_abnormal_pharynx_morphology	0.88059298
73	MP0005195_abnormal_posterior_eye	0.87026429
74	MP0002572_abnormal_emotion/affect_behav	0.84361632
75	MP0002067_abnormal_sensory_capabilities	0.83911127
76	MP0001501_abnormal_sleep_pattern	0.83610630
77	MP0003950_abnormal_plasma_membrane	0.82093176
78	MP0001984_abnormal_olfaction	0.80611442
79	MP0002557_abnormal_social/conspecific_i	0.80562543
80	MP0008789_abnormal_olfactory_epithelium	0.80398118
81	MP0002734_abnormal_mechanical_nocicepti	0.80200509
82	MP0000230_abnormal_systemic_arterial	0.78068004
83	MP0005389_reproductive_system_phenotype	0.75735909
84	MP0004215_abnormal_myocardial_fiber	0.75579162
85	MP0002751_abnormal_autonomic_nervous	0.75325540
86	MP0001970_abnormal_pain_threshold	0.75105306
87	MP0003646_muscle_fatigue	0.74583016
88	MP0005085_abnormal_gallbladder_physiolo	0.73751694
89	MP0003937_abnormal_limbs/digits/tail_de	0.73493216
90	MP0000778_abnormal_nervous_system	0.73454263
91	MP0004043_abnormal_pH_regulation	0.72417480
92	MP0005395_other_phenotype	0.72338039
93	MP0005187_abnormal_penis_morphology	0.71157097
94	MP0009780_abnormal_chondrocyte_physiolo	0.69490895
95	MP0001919_abnormal_reproductive_system	0.69477689
96	MP0003121_genomic_imprinting	0.68529823
97	MP0000566_synostosis	0.68196700
98	MP0000538_abnormal_urinary_bladder	0.67341191
99	MP0004085_abnormal_heartbeat	0.66831702
100	MP0005503_abnormal_tendon_morphology	0.65828431

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Limb dystonia (HP:0002451)	4.63593212
2	Pancreatic cysts (HP:0001737)	4.18997754
3	Acute necrotizing encephalopathy (HP:0006965)	3.98998622
4	Hypothermia (HP:0002045)	3.88521333
5	Mitochondrial inheritance (HP:0001427)	3.75489828
6	Progressive macrocephaly (HP:0004481)	3.73379444
7	Congenital, generalized hypertrichosis (HP:0004540)	3.55392013
8	Acute encephalopathy (HP:0006846)	3.48950093
9	Increased hepatocellular lipid droplets (HP:0006565)	3.40907872
10	Pancreatic fibrosis (HP:0100732)	3.37700321
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37181399
12	True hermaphroditism (HP:0010459)	3.30799756
13	Increased CSF lactate (HP:0002490)	3.27870065
14	Type 2 muscle fiber atrophy (HP:0003554)	3.18170992
15	Molar tooth sign on MRI (HP:0002419)	3.10311746
16	Abnormality of midbrain morphology (HP:0002418)	3.10311746
17	Lipid accumulation in hepatocytes (HP:0006561)	3.06529269
18	Exertional dyspnea (HP:0002875)	3.04933141
19	Renal Fanconi syndrome (HP:0001994)	2.92772032
20	Congenital stationary night blindness (HP:0007642)	2.90571619
21	Hepatocellular necrosis (HP:0001404)	2.87051704
22	Type II lissencephaly (HP:0007260)	2.78889104
23	Stomatitis (HP:0010280)	2.70711624
24	Increased IgE level (HP:0003212)	2.69153788
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.68707924
26	Abnormal pupillary function (HP:0007686)	2.62155645
27	Hepatic necrosis (HP:0002605)	2.59154797
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.58019492
29	3-Methylglutaconic aciduria (HP:0003535)	2.50019809
30	Muscle fiber atrophy (HP:0100295)	2.46208594
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.45450909
32	Medial flaring of the eyebrow (HP:0010747)	2.44675457
33	Nephronophthisis (HP:0000090)	2.41051359
34	Polydipsia (HP:0001959)	2.40922756
35	Abnormal drinking behavior (HP:0030082)	2.40922756
36	Abnormality of the renal cortex (HP:0011035)	2.35516603
37	Tubular atrophy (HP:0000092)	2.34717481
38	Cerebral edema (HP:0002181)	2.33758723
39	Abolished electroretinogram (ERG) (HP:0000550)	2.32736574
40	Abnormality of urine glucose concentration (HP:0011016)	2.32676081
41	Glycosuria (HP:0003076)	2.32676081
42	Absent/shortened dynein arms (HP:0200106)	2.29956922
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.29956922
44	Retinal dysplasia (HP:0007973)	2.28227815
45	Chronic hepatic failure (HP:0100626)	2.27747314
46	Optic disc pallor (HP:0000543)	2.25247549
47	Bile duct proliferation (HP:0001408)	2.24250424
48	Abnormal biliary tract physiology (HP:0012439)	2.24250424
49	Short hallux (HP:0010109)	2.21854212
50	Neuroendocrine neoplasm (HP:0100634)	2.21210339
51	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.21056101
52	Decreased central vision (HP:0007663)	2.18341530
53	Concave nail (HP:0001598)	2.17219857
54	Abnormality of the renal medulla (HP:0100957)	2.16901007
55	Limb hypertonia (HP:0002509)	2.16196841
56	Increased IgM level (HP:0003496)	2.12126072
57	Abnormality of B cell number (HP:0010975)	2.11388150
58	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.08824464
59	Cystic liver disease (HP:0006706)	2.07358344
60	Mesangial abnormality (HP:0001966)	2.07189188
61	Intestinal atresia (HP:0011100)	2.06085735
62	Recurrent bronchitis (HP:0002837)	2.05601570
63	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.04157316
64	Respiratory difficulties (HP:0002880)	2.01895819
65	Male pseudohermaphroditism (HP:0000037)	2.01099620
66	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97438023
67	Respiratory failure (HP:0002878)	1.96680608
68	Abnormality of renal resorption (HP:0011038)	1.93440449
69	Bony spicule pigmentary retinopathy (HP:0007737)	1.93249398
70	Panhypogammaglobulinemia (HP:0003139)	1.91904118
71	Abnormal number of erythroid precursors (HP:0012131)	1.91485845
72	Volvulus (HP:0002580)	1.91149426
73	Sclerocornea (HP:0000647)	1.91082284
74	Abnormality of secondary sexual hair (HP:0009888)	1.89396682
75	Abnormality of the axillary hair (HP:0100134)	1.89396682
76	B lymphocytopenia (HP:0010976)	1.86394523
77	Pigmentary retinal degeneration (HP:0001146)	1.85068377
78	Lactic acidosis (HP:0003128)	1.84342066
79	Chronic sinusitis (HP:0011109)	1.83546146
80	Pheochromocytoma (HP:0002666)	1.83407410
81	IgG deficiency (HP:0004315)	1.82534159
82	Abnormality of the anterior horn cell (HP:0006802)	1.82331398
83	Degeneration of anterior horn cells (HP:0002398)	1.82331398
84	Cerebellar dysplasia (HP:0007033)	1.81909238
85	Hyperglycinuria (HP:0003108)	1.81725277
86	Abnormality of the ileum (HP:0001549)	1.80559887
87	Hypomagnesemia (HP:0002917)	1.78794328
88	Leukodystrophy (HP:0002415)	1.77477488
89	Increased serum lactate (HP:0002151)	1.77420289
90	Colon cancer (HP:0003003)	1.77240942
91	Increased intramyocellular lipid droplets (HP:0012240)	1.77212880
92	Hemiparesis (HP:0001269)	1.74518402
93	Polyuria (HP:0000103)	1.73800463
94	Large for gestational age (HP:0001520)	1.72145061
95	Anencephaly (HP:0002323)	1.71909555
96	Furrowed tongue (HP:0000221)	1.71595913
97	Weak cry (HP:0001612)	1.70496172
98	Thyroiditis (HP:0100646)	1.69621416
99	Hypoplasia of the uterus (HP:0000013)	1.69228480
100	Prominent supraorbital ridges (HP:0000336)	1.67062087

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.26563543
2	ADRBK2	3.06647236
3	MUSK	2.86963567
4	BMPR1B	2.74852087
5	TLK1	2.72890414
6	OXSR1	2.65548439
7	STK39	2.59868715
8	MAP3K9	2.57512149
9	WNK4	2.53475656
10	NUAK1	2.45455858
11	VRK2	2.27731818
12	MAPKAPK5	2.20567399
13	VRK1	2.18693306
14	GRK1	2.13491130
15	BUB1	2.11243957
16	MAP3K12	1.97481763
17	BCKDK	1.86709377
18	WNK3	1.67810708
19	ZAK	1.66379728
20	PNCK	1.66038489
21	TNIK	1.62983945
22	TAOK3	1.53036555
23	PLK2	1.44174170
24	KIT	1.43045282
25	TAF1	1.42956522
26	MAPK13	1.42736658
27	MAPK15	1.42378233
28	CCNB1	1.41041205
29	TGFBR1	1.30489687
30	WEE1	1.29118753
31	FGFR2	1.27589954
32	STK24	1.26188571
33	INSRR	1.22842511
34	TXK	1.19026666
35	PLK4	1.11648183
36	PDK2	1.10472691
37	FLT3	1.06430394
38	ACVR1B	1.03657650
39	RPS6KA5	0.99877268
40	CDC7	0.99431878
41	NTRK3	0.95836050
42	NTRK2	0.95084220
43	GRK7	0.88993891
44	BMPR2	0.88354078
45	ADRBK1	0.85138555
46	NLK	0.83644615
47	MARK1	0.79733911
48	PLK3	0.79126812
49	STK3	0.78092816
50	PKN1	0.78002555
51	MAP3K2	0.77305270
52	CSNK1G1	0.76828870
53	MAP4K2	0.76018827
54	GRK5	0.71574499
55	CDK8	0.71407974
56	SYK	0.69042535
57	TRIM28	0.68736202
58	STK38L	0.68022789
59	TSSK6	0.67053583
60	PRKCE	0.64949550
61	CSNK1G3	0.63252236
62	ERBB3	0.61931342
63	IKBKB	0.61404860
64	TEC	0.60986173
65	CDK3	0.60031414
66	MAP3K4	0.59741856
67	CHEK2	0.58783572
68	MARK3	0.57909463
69	PIK3CG	0.55356043
70	MST4	0.55017344
71	PINK1	0.54377831
72	KSR1	0.54098834
73	MKNK2	0.49698317
74	EPHA4	0.49510369
75	LYN	0.48048670
76	ERBB2	0.48040122
77	NEK2	0.47163026
78	RAF1	0.46804934
79	MYLK	0.46654575
80	EPHB2	0.46455562
81	ITK	0.45886888
82	CSNK1G2	0.44175943
83	PRKCG	0.43827376
84	IKBKE	0.42684147
85	CSNK1A1	0.42285168
86	DYRK2	0.41790323
87	BRSK2	0.41535989
88	ILK	0.39091005
89	DAPK3	0.37999451
90	CAMK2A	0.37434695
91	PIK3CA	0.37354475
92	MINK1	0.36953490
93	CSF1R	0.36740533
94	EIF2AK2	0.36577424
95	PAK3	0.35375588
96	DAPK2	0.34441507
97	KDR	0.33839824
98	AURKB	0.32007424
99	PRKACA	0.31501692
100	CSNK1D	0.30269754

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.06494904
2	Parkinsons disease_Homo sapiens_hsa05012	3.47896557
3	Asthma_Homo sapiens_hsa05310	2.95997652
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.66682156
5	Protein export_Homo sapiens_hsa03060	2.66109250
6	Proteasome_Homo sapiens_hsa03050	2.45387304
7	Alzheimers disease_Homo sapiens_hsa05010	2.43005718
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.42455189
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.37342460
10	Allograft rejection_Homo sapiens_hsa05330	2.33558172
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.24287082
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.23375361
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.07309127
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.06710157
15	Huntingtons disease_Homo sapiens_hsa05016	2.04706512
16	Graft-versus-host disease_Homo sapiens_hsa05332	2.03005910
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.94752515
18	Caffeine metabolism_Homo sapiens_hsa00232	1.92517080
19	Ribosome_Homo sapiens_hsa03010	1.89904836
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89283257
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.77793813
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68463476
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.61790972
24	Phototransduction_Homo sapiens_hsa04744	1.57833231
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.55297630
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43500723
27	Nicotine addiction_Homo sapiens_hsa05033	1.41216702
28	Homologous recombination_Homo sapiens_hsa03440	1.40555125
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39394404
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.38254438
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35316058
32	Antigen processing and presentation_Homo sapiens_hsa04612	1.32014920
33	Tyrosine metabolism_Homo sapiens_hsa00350	1.17868073
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.16107976
35	Butanoate metabolism_Homo sapiens_hsa00650	1.12802731
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07206523
37	Alcoholism_Homo sapiens_hsa05034	1.03411641
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02056567
39	RNA polymerase_Homo sapiens_hsa03020	1.00524446
40	Phenylalanine metabolism_Homo sapiens_hsa00360	0.99797364
41	Basal transcription factors_Homo sapiens_hsa03022	0.98830429
42	Histidine metabolism_Homo sapiens_hsa00340	0.97234742
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96317889
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92250682
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91986164
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91661335
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.90925451
48	Peroxisome_Homo sapiens_hsa04146	0.90181420
49	Serotonergic synapse_Homo sapiens_hsa04726	0.89054724
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88338447
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87340695
52	Cocaine addiction_Homo sapiens_hsa05030	0.86618222
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.83401838
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.83061209
55	Mineral absorption_Homo sapiens_hsa04978	0.82960837
56	Propanoate metabolism_Homo sapiens_hsa00640	0.82327120
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.81103824
58	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.78955870
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.75342714
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74447604
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74178127
62	Viral myocarditis_Homo sapiens_hsa05416	0.70988637
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69301920
64	GABAergic synapse_Homo sapiens_hsa04727	0.68785464
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64551078
66	RNA degradation_Homo sapiens_hsa03018	0.64322468
67	Retinol metabolism_Homo sapiens_hsa00830	0.63945456
68	Morphine addiction_Homo sapiens_hsa05032	0.63712590
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.62995156
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.61145267
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58530523
72	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56712229
73	Amphetamine addiction_Homo sapiens_hsa05031	0.56229177
74	Olfactory transduction_Homo sapiens_hsa04740	0.53228309
75	Circadian entrainment_Homo sapiens_hsa04713	0.52878319
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50909676
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50619256
78	Taste transduction_Homo sapiens_hsa04742	0.50251651
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48169018
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47749244
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47039406
82	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.44748479
83	Sulfur metabolism_Homo sapiens_hsa00920	0.44528606
84	Metabolic pathways_Homo sapiens_hsa01100	0.43730006
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43673016
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43290125
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.42005467
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.41273709
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.40498810
90	Purine metabolism_Homo sapiens_hsa00230	0.39955516
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.39396986
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38762433
93	Mismatch repair_Homo sapiens_hsa03430	0.38217985
94	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38079056
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.37517139
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36955882
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36246485
98	Spliceosome_Homo sapiens_hsa03040	0.27001368
99	Leishmaniasis_Homo sapiens_hsa05140	0.26434250
100	Nucleotide excision repair_Homo sapiens_hsa03420	0.25483957

UBE2V1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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