ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neuronal ion channel clustering (GO:0045161)	9.37417959
2	axon ensheathment in central nervous system (GO:0032291)	8.89685473
3	central nervous system myelination (GO:0022010)	8.89685473
4	presynaptic membrane organization (GO:0097090)	8.74073611
5	positive regulation of growth hormone secretion (GO:0060124)	8.02285920
6	response to pheromone (GO:0019236)	6.99982083
7	tachykinin receptor signaling pathway (GO:0007217)	6.91009530
8	regulation of growth hormone secretion (GO:0060123)	6.17597606
9	histamine secretion (GO:0001821)	6.00314225
10	C4-dicarboxylate transport (GO:0015740)	5.64789868
11	parturition (GO:0007567)	5.44283659
12	DNA damage induced protein phosphorylation (GO:0006975)	5.27909046
13	axonal fasciculation (GO:0007413)	5.17267665
14	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	4.95833226
15	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.80256687
16	histamine transport (GO:0051608)	4.65331321
17	respiratory chain complex IV assembly (GO:0008535)	4.61176524
18	negative regulation of Ras GTPase activity (GO:0034261)	4.39336207
19	spindle assembly involved in mitosis (GO:0090307)	4.34517876
20	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.33507126
21	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	4.24982867
22	replicative senescence (GO:0090399)	4.20305214
23	protein-cofactor linkage (GO:0018065)	4.05058050
24	positive regulation of Rap GTPase activity (GO:0032854)	3.96689830
25	ovulation cycle (GO:0042698)	3.94234890
26	glycerophospholipid catabolic process (GO:0046475)	3.92764950
27	cytochrome complex assembly (GO:0017004)	3.85912832
28	regulation of cilium movement (GO:0003352)	3.81814712
29	negative regulation of glial cell proliferation (GO:0060253)	3.81570189
30	macroautophagy (GO:0016236)	3.78262775
31	neuron recognition (GO:0008038)	3.71324143
32	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.69600421
33	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.61139229
34	phenylpropanoid metabolic process (GO:0009698)	3.60361475
35	regulation of Rap GTPase activity (GO:0032317)	3.60096643
36	regulation of astrocyte differentiation (GO:0048710)	3.58558227
37	negative regulation of acute inflammatory response (GO:0002674)	3.55234283
38	negative regulation of potassium ion transport (GO:0043267)	3.50896060
39	adult walking behavior (GO:0007628)	3.45900893
40	glyoxylate metabolic process (GO:0046487)	3.39658413
41	epithelial cilium movement (GO:0003351)	3.37014932
42	striatum development (GO:0021756)	3.36685065
43	transmission of nerve impulse (GO:0019226)	3.34315483
44	azole transport (GO:0045117)	3.32497182
45	kynurenine metabolic process (GO:0070189)	3.22870281
46	behavioral response to ethanol (GO:0048149)	3.22276670
47	regulation of microtubule-based movement (GO:0060632)	3.22189392
48	negative regulation of macroautophagy (GO:0016242)	3.20558828
49	indole-containing compound catabolic process (GO:0042436)	3.17158982
50	indolalkylamine catabolic process (GO:0046218)	3.17158982
51	tryptophan catabolic process (GO:0006569)	3.17158982
52	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	3.11848603
53	locomotory exploration behavior (GO:0035641)	3.10578993
54	negative regulation of sodium ion transport (GO:0010766)	3.07998175
55	negative regulation of catecholamine secretion (GO:0033604)	3.04616270
56	neuropeptide signaling pathway (GO:0007218)	3.03605070
57	somite rostral/caudal axis specification (GO:0032525)	2.99909992
58	transferrin transport (GO:0033572)	2.97951085
59	cerebellar granule cell differentiation (GO:0021707)	2.96560072
60	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.90002239
61	heterochromatin organization (GO:0070828)	2.85278510
62	phagosome maturation (GO:0090382)	2.84226556
63	cellular response to leptin stimulus (GO:0044320)	2.83340821
64	ferric iron transport (GO:0015682)	2.79503668
65	trivalent inorganic cation transport (GO:0072512)	2.79503668
66	behavioral response to nicotine (GO:0035095)	2.79122994
67	behavioral fear response (GO:0001662)	2.76326504
68	behavioral defense response (GO:0002209)	2.76326504
69	cellular response to glucocorticoid stimulus (GO:0071385)	2.75726713
70	regulation of gonadotropin secretion (GO:0032276)	2.74997932
71	hypothalamus development (GO:0021854)	2.73416875
72	nonmotile primary cilium assembly (GO:0035058)	2.72461718
73	forebrain neuron differentiation (GO:0021879)	2.71701638
74	sensory perception of smell (GO:0007608)	2.68790650
75	platelet dense granule organization (GO:0060155)	2.65203879
76	negative regulation of activin receptor signaling pathway (GO:0032926)	2.65047414
77	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.64893873
78	spinal cord association neuron differentiation (GO:0021527)	2.60338567
79	synaptonemal complex assembly (GO:0007130)	2.60105083
80	fear response (GO:0042596)	2.58655084
81	basic amino acid transport (GO:0015802)	2.57627978
82	synaptic transmission, dopaminergic (GO:0001963)	2.54792146
83	mating behavior (GO:0007617)	2.54728312
84	replication fork processing (GO:0031297)	2.53797725
85	cellular response to corticosteroid stimulus (GO:0071384)	2.53339342
86	negative regulation of response to extracellular stimulus (GO:0032105)	2.51711298
87	negative regulation of response to nutrient levels (GO:0032108)	2.51711298
88	cell differentiation in hindbrain (GO:0021533)	2.50658556
89	body morphogenesis (GO:0010171)	2.48744268
90	protein polyglutamylation (GO:0018095)	2.48299049
91	peristalsis (GO:0030432)	2.47434012
92	receptor internalization (GO:0031623)	2.47260712
93	negative regulation of muscle cell apoptotic process (GO:0010656)	2.44020603
94	mechanosensory behavior (GO:0007638)	2.42266994
95	water-soluble vitamin biosynthetic process (GO:0042364)	2.42166292
96	synaptonemal complex organization (GO:0070193)	2.41901595
97	negative regulation of circadian rhythm (GO:0042754)	2.40845784
98	auditory behavior (GO:0031223)	2.39265907
99	substrate-independent telencephalic tangential migration (GO:0021826)	12.3763462
100	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	12.3763462

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.08340531
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.14884017
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.34713651
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.75980024
5	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.56298475
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55006764
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38609211
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.14109017
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.10755284
10	VDR_22108803_ChIP-Seq_LS180_Human	2.04310387
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.00370068
12	REST_21632747_ChIP-Seq_MESCs_Mouse	1.99477122
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92628760
14	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.90558504
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.88371487
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85947770
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.84588789
18	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.74099609
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73407828
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72024639
21	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61879785
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.60972873
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.59827188
24	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.57826022
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56807074
26	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54111198
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53887416
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.53488226
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.52140377
30	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.51524167
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49428497
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.49008030
33	P300_19829295_ChIP-Seq_ESCs_Human	1.44765084
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.44241517
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44241517
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.43774328
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.41051616
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40819171
39	NFYB_21822215_ChIP-Seq_K562_Human	1.38336249
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36744310
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35395641
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35101761
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34344099
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32805293
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.31103060
46	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.29497953
47	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.28800351
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27326014
49	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.26822601
50	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.25313225
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24744570
52	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.24484544
53	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.24289171
54	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.23923988
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23795258
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23651834
57	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22748659
58	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22344462
59	EWS_26573619_Chip-Seq_HEK293_Human	1.22085485
60	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.20977594
61	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.20748205
62	RBPJ_21746931_ChIP-Seq_IB4_Human	1.20268629
63	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.20248253
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19028561
65	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18817500
66	IGF1R_20145208_ChIP-Seq_DFB_Human	1.18545534
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18239907
68	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18214333
69	NCOR_22424771_ChIP-Seq_293T_Human	1.17969041
70	NFYA_21822215_ChIP-Seq_K562_Human	1.17569836
71	PHF8_20622853_ChIP-Seq_HELA_Human	1.16934780
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16743981
73	AR_21572438_ChIP-Seq_LNCaP_Human	1.15658974
74	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14792296
75	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.14771776
76	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.14172482
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13876186
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12786439
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12681856
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.12384916
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11865067
82	TCF4_23295773_ChIP-Seq_U87_Human	1.11846956
83	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.10910581
84	TBL1_22424771_ChIP-Seq_293T_Human	1.10320885
85	AR_25329375_ChIP-Seq_VCAP_Human	1.09318750
86	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08449624
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08196288
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06952103
89	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.06564613
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06513793
91	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.06440225
92	ETV1_20927104_ChIP-Seq_GIST48_Human	1.05345616
93	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.04376256
94	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.03316056
95	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.01636946
96	FUS_26573619_Chip-Seq_HEK293_Human	1.00867097
97	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.00264109
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00066680
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99756722
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99342831

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	8.93657314
2	MP0003787_abnormal_imprinting	5.15755168
3	MP0003123_paternal_imprinting	4.30821952
4	MP0008877_abnormal_DNA_methylation	3.66903176
5	MP0003011_delayed_dark_adaptation	3.52076699
6	MP0002822_catalepsy	3.29779499
7	MP0002876_abnormal_thyroid_physiology	3.04544168
8	MP0002254_reproductive_system_inflammat	2.80314382
9	MP0005379_endocrine/exocrine_gland_phen	2.61561504
10	MP0003122_maternal_imprinting	2.51121278
11	MP0001188_hyperpigmentation	2.48315286
12	MP0003315_abnormal_perineum_morphology	2.26991005
13	MP0001348_abnormal_lacrimal_gland	2.14446713
14	MP0003121_genomic_imprinting	2.11398275
15	MP0009745_abnormal_behavioral_response	1.95363706
16	MP0008057_abnormal_DNA_replication	1.93798377
17	MP0000427_abnormal_hair_cycle	1.90106520
18	MP0001764_abnormal_homeostasis	1.89643789
19	MP0003880_abnormal_central_pattern	1.87327614
20	MP0001501_abnormal_sleep_pattern	1.84063099
21	MP0009764_decreased_sensitivity_to	1.68564132
22	MP0006276_abnormal_autonomic_nervous	1.67048206
23	MP0002163_abnormal_gland_morphology	1.66634274
24	MP0001984_abnormal_olfaction	1.64996627
25	MP0004145_abnormal_muscle_electrophysio	1.63734845
26	MP0005646_abnormal_pituitary_gland	1.62755858
27	MP0002638_abnormal_pupillary_reflex	1.62623755
28	MP0005535_abnormal_body_temperature	1.57567487
29	MP0008995_early_reproductive_senescence	1.57117095
30	MP0004043_abnormal_pH_regulation	1.52276858
31	MP0002139_abnormal_hepatobiliary_system	1.48092958
32	MP0002184_abnormal_innervation	1.45492896
33	MP0001661_extended_life_span	1.44686690
34	MP0005187_abnormal_penis_morphology	1.42749735
35	MP0004134_abnormal_chest_morphology	1.38820218
36	MP0005084_abnormal_gallbladder_morpholo	1.37283120
37	MP0002557_abnormal_social/conspecific_i	1.36225824
38	MP0004859_abnormal_synaptic_plasticity	1.31774364
39	MP0002138_abnormal_hepatobiliary_system	1.30603754
40	MP0002909_abnormal_adrenal_gland	1.30073545
41	MP0002272_abnormal_nervous_system	1.29828944
42	MP0001727_abnormal_embryo_implantation	1.21252684
43	MP0000955_abnormal_spinal_cord	1.20285546
44	MP0005551_abnormal_eye_electrophysiolog	1.19393912
45	MP0004130_abnormal_muscle_cell	1.18093196
46	MP0002735_abnormal_chemical_nociception	1.16343415
47	MP0001970_abnormal_pain_threshold	1.15186323
48	MP0004133_heterotaxia	1.14403934
49	MP0004147_increased_porphyrin_level	1.06993552
50	MP0001324_abnormal_eye_pigmentation	1.05679079
51	MP0003959_abnormal_lean_body	1.05588223
52	MP0002572_abnormal_emotion/affect_behav	1.05162218
53	MP0001905_abnormal_dopamine_level	1.04362218
54	MP0000538_abnormal_urinary_bladder	1.03740997
55	MP0005266_abnormal_metabolism	1.00850980
56	MP0002063_abnormal_learning/memory/cond	0.97180323
57	MP0002733_abnormal_thermal_nociception	0.96430223
58	MP0001968_abnormal_touch/_nociception	0.96098948
59	MP0004142_abnormal_muscle_tone	0.90492378
60	MP0003890_abnormal_embryonic-extraembry	0.90313042
61	MP0002102_abnormal_ear_morphology	0.86550787
62	MP0005645_abnormal_hypothalamus_physiol	0.86349306
63	MP0005075_abnormal_melanosome_morpholog	0.84629684
64	MP0009046_muscle_twitch	0.83866044
65	MP0006292_abnormal_olfactory_placode	0.81459566
66	MP0003195_calcinosis	0.78076557
67	MP0005253_abnormal_eye_physiology	0.77976231
68	MP0009840_abnormal_foam_cell	0.77448788
69	MP0008789_abnormal_olfactory_epithelium	0.76870772
70	MP0002752_abnormal_somatic_nervous	0.76680990
71	MP0002882_abnormal_neuron_morphology	0.73661881
72	MP0002734_abnormal_mechanical_nocicepti	0.72444303
73	MP0010386_abnormal_urinary_bladder	0.72007283
74	MP0002064_seizures	0.71456971
75	MP0005376_homeostasis/metabolism_phenot	0.71182283
76	MP0004085_abnormal_heartbeat	0.70458380
77	MP0003635_abnormal_synaptic_transmissio	0.68767173
78	MP0005409_darkened_coat_color	0.68580231
79	MP0001666_abnormal_nutrient_absorption	0.67734243
80	MP0002210_abnormal_sex_determination	0.67429155
81	MP0001440_abnormal_grooming_behavior	0.66460985
82	MP0000631_abnormal_neuroendocrine_gland	0.61335364
83	MP0005636_abnormal_mineral_homeostasis	0.60257873
84	MP0005174_abnormal_tail_pigmentation	0.59354763
85	MP0003953_abnormal_hormone_level	0.58341810
86	MP0004381_abnormal_hair_follicle	0.57983135
87	MP0004233_abnormal_muscle_weight	0.57776403
88	MP0004019_abnormal_vitamin_homeostasis	0.56698498
89	MP0003950_abnormal_plasma_membrane	0.52956184
90	MP0005386_behavior/neurological_phenoty	0.51956679
91	MP0004924_abnormal_behavior	0.51956679
92	MP0005499_abnormal_olfactory_system	0.51875190
93	MP0005394_taste/olfaction_phenotype	0.51875190
94	MP0010329_abnormal_lipoprotein_level	0.51820362
95	MP0005195_abnormal_posterior_eye	0.51541162
96	MP0005448_abnormal_energy_balance	0.49984590
97	MP0003786_premature_aging	0.49815545
98	MP0001529_abnormal_vocalization	0.48587472
99	MP0001929_abnormal_gametogenesis	0.48369598
100	MP0001145_abnormal_male_reproductive	0.46332155

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neoplasm of the adrenal cortex (HP:0100641)	7.53453637
2	Metaphyseal dysplasia (HP:0100255)	6.31558192
3	Stomach cancer (HP:0012126)	5.41800128
4	Neoplasm of the adrenal gland (HP:0100631)	4.36206159
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.17254580
6	Abnormality of the phalanges of the 2nd finger (HP:0009541)	4.04452741
7	Congenital malformation of the right heart (HP:0011723)	3.68941007
8	Double outlet right ventricle (HP:0001719)	3.68941007
9	Anomalous pulmonary venous return (HP:0010772)	3.68148873
10	Abnormal pancreas size (HP:0012094)	3.65247754
11	Amaurosis fugax (HP:0100576)	3.59839082
12	Confusion (HP:0001289)	3.49794224
13	Bile duct proliferation (HP:0001408)	3.48552663
14	Abnormal biliary tract physiology (HP:0012439)	3.48552663
15	Hypoalphalipoproteinemia (HP:0003233)	3.40127322
16	Neuroendocrine neoplasm (HP:0100634)	3.26438836
17	Hyperventilation (HP:0002883)	3.20493392
18	Abnormality of the pulmonary veins (HP:0011718)	3.20160263
19	Intrahepatic cholestasis (HP:0001406)	3.02449303
20	Abnormal rod and cone electroretinograms (HP:0008323)	3.00964973
21	Anosmia (HP:0000458)	2.91219004
22	Medial flaring of the eyebrow (HP:0010747)	2.83640791
23	Abolished electroretinogram (ERG) (HP:0000550)	2.79012855
24	Calf muscle hypertrophy (HP:0008981)	2.75475140
25	3-Methylglutaconic aciduria (HP:0003535)	2.73142187
26	Abnormality of methionine metabolism (HP:0010901)	2.72385915
27	Hyperthyroidism (HP:0000836)	2.71195000
28	Attenuation of retinal blood vessels (HP:0007843)	2.63636373
29	Prolonged partial thromboplastin time (HP:0003645)	2.61044529
30	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.55667890
31	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.46085485
32	Asplenia (HP:0001746)	2.44604583
33	Pancreatic fibrosis (HP:0100732)	2.44412079
34	Pendular nystagmus (HP:0012043)	2.42978715
35	Muscle hypertrophy of the lower extremities (HP:0008968)	2.37274479
36	Glioma (HP:0009733)	2.33917529
37	Broad-based gait (HP:0002136)	2.32253754
38	Tinnitus (HP:0000360)	2.30942498
39	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.30743017
40	Constricted visual fields (HP:0001133)	2.30623223
41	Congenital stationary night blindness (HP:0007642)	2.28874725
42	True hermaphroditism (HP:0010459)	2.28652195
43	Neonatal respiratory distress (HP:0002643)	2.27244908
44	Hypolipoproteinemia (HP:0010981)	2.25548697
45	Hypogonadotrophic hypogonadism (HP:0000044)	2.24777241
46	Infertility (HP:0000789)	2.24573616
47	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.23785504
48	Abnormal sex determination (HP:0012244)	2.22749306
49	Sex reversal (HP:0012245)	2.22749306
50	Meningioma (HP:0002858)	2.21844004
51	Reduced antithrombin III activity (HP:0001976)	2.21820313
52	Abnormality of the vocal cords (HP:0008777)	2.21469033
53	Prostate neoplasm (HP:0100787)	2.19631202
54	Nephronophthisis (HP:0000090)	2.18328750
55	Abnormality of the 2nd finger (HP:0004100)	2.17441454
56	Tubulointerstitial nephritis (HP:0001970)	2.15263221
57	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.15021611
58	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.13684324
59	Central scotoma (HP:0000603)	2.11000806
60	Progressive inability to walk (HP:0002505)	2.10937662
61	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.06004911
62	Thyroiditis (HP:0100646)	2.05518664
63	Supernumerary spleens (HP:0009799)	2.05216983
64	Congenital, generalized hypertrichosis (HP:0004540)	2.04077687
65	Abnormality of the intrinsic pathway (HP:0010989)	2.02545066
66	Pancreatic cysts (HP:0001737)	1.99850036
67	Abnormality of midbrain morphology (HP:0002418)	1.97328768
68	Molar tooth sign on MRI (HP:0002419)	1.97328768
69	Enlarged penis (HP:0000040)	1.94950770
70	Agitation (HP:0000713)	1.94720448
71	Menstrual irregularities (HP:0000858)	1.89495475
72	Breast carcinoma (HP:0003002)	1.89010925
73	Fetal akinesia sequence (HP:0001989)	1.85814720
74	Macular degeneration (HP:0000608)	1.85359245
75	Abnormality of the renal medulla (HP:0100957)	1.83282772
76	Cerebral edema (HP:0002181)	1.82816490
77	Congenital primary aphakia (HP:0007707)	1.81278405
78	Stenosis of the external auditory canal (HP:0000402)	1.80782381
79	Abnormality of dental color (HP:0011073)	1.79925468
80	Gonadotropin excess (HP:0000837)	1.79710448
81	Ketosis (HP:0001946)	1.79579393
82	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.79576355
83	Macroorchidism (HP:0000053)	1.79332721
84	Severe combined immunodeficiency (HP:0004430)	1.78741717
85	Hypercholesterolemia (HP:0003124)	1.78545822
86	Hyperlipoproteinemia (HP:0010980)	1.78518547
87	Short middle phalanx of the 5th finger (HP:0004220)	1.77325026
88	Genital tract atresia (HP:0001827)	1.76608585
89	Testicular neoplasm (HP:0010788)	1.76007428
90	Gait imbalance (HP:0002141)	1.74597536
91	Enlarged kidneys (HP:0000105)	1.73726159
92	Anencephaly (HP:0002323)	1.72722459
93	Prolonged neonatal jaundice (HP:0006579)	1.72393656
94	Ketoacidosis (HP:0001993)	1.70689314
95	Adrenal hypoplasia (HP:0000835)	1.68773751
96	Neoplasm of the peripheral nervous system (HP:0100007)	1.68627505
97	Hepatoblastoma (HP:0002884)	1.66742850
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.66338125
99	Truncus arteriosus (HP:0001660)	1.65312318
100	Urinary bladder sphincter dysfunction (HP:0002839)	1.63914767

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.04409515
2	STK24	2.93458525
3	PINK1	2.52924239
4	BMPR1B	2.45533407
5	FRK	2.19319452
6	TTK	2.18739130
7	ZAK	12.6657711
8	NTRK3	1.86954274
9	MKNK2	1.78592550
10	WNK3	1.78499502
11	TNK2	1.62972360
12	DYRK3	1.57248620
13	MAP3K4	1.44215735
14	PLK3	1.38780819
15	NTRK2	1.33664871
16	GRK1	1.32430650
17	BMPR2	1.22463198
18	MKNK1	1.19947029
19	TNIK	1.19631481
20	RIPK4	1.19010581
21	STK38	1.16863549
22	WNK4	1.10993095
23	MAPK13	1.08123096
24	MUSK	1.04674055
25	ADRBK2	0.94050935
26	INSRR	0.88822900
27	BRSK2	0.85936261
28	MAP4K2	0.85801159
29	PRKCG	0.76203796
30	SIK2	0.75861933
31	CASK	0.75139134
32	CHEK2	0.74742500
33	MAP2K4	0.72267069
34	NEK9	0.71521241
35	CDC7	0.69957751
36	ERN1	0.68999914
37	DYRK2	0.67718633
38	STK39	0.65439910
39	BCR	0.62597569
40	PRKCQ	0.56674537
41	PLK1	0.55899394
42	PIK3CG	0.55838712
43	SGK494	0.55400526
44	SGK223	0.55400526
45	SGK2	0.52267661
46	CAMKK2	0.51982793
47	MINK1	0.49971044
48	TGFBR1	0.49294920
49	ATR	0.49285138
50	BRD4	0.48796159
51	STK38L	0.48784615
52	AKT3	0.47541984
53	CSK	0.44112733
54	MAP2K7	0.40884415
55	PNCK	0.38719568
56	STK3	0.38251037
57	VRK1	0.37559288
58	SGK3	0.37111459
59	PIK3CA	0.36428261
60	BRSK1	0.35927211
61	MAPK8	0.34093736
62	PHKG1	0.33987983
63	PHKG2	0.33987983
64	PRKG1	0.32312661
65	TRPM7	0.32196343
66	TAF1	0.31833545
67	DYRK1A	0.31164946
68	PRKCE	0.29914923
69	ADRBK1	0.28609020
70	TAOK3	0.28236926
71	DYRK1B	0.27387350
72	TLK1	0.26315746
73	VRK2	0.25441696
74	TXK	0.24876243
75	MAPK4	0.24843358
76	PRKD3	0.24162225
77	PRKCD	0.23309990
78	CAMKK1	0.23157669
79	PRKACB	0.22633871
80	PRKACA	0.22577152
81	NEK1	0.22423006
82	HIPK2	0.21699012
83	TEC	0.21518565
84	PAK1	0.20940937
85	PAK3	0.20792192
86	FER	0.20545811
87	TRIM28	0.20491803
88	MAP3K9	0.20231148
89	CSNK1E	0.19843375
90	NUAK1	0.19784564
91	CDK8	0.19199594
92	PRKDC	0.19194795
93	PLK4	0.18793679
94	PRKCA	0.17131639
95	MAP3K1	0.16794951
96	SYK	0.16486274
97	IRAK3	0.16353431
98	MAP3K12	0.16269540
99	EPHA4	0.16031962
100	ATM	0.14822157

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Collecting duct acid secretion_Homo sapiens_hsa04966	5.51521853
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.98856098
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.92411205
4	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.77645457
5	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.72380296
6	Vibrio cholerae infection_Homo sapiens_hsa05110	2.63961019
7	Long-term depression_Homo sapiens_hsa04730	2.20336284
8	Insulin secretion_Homo sapiens_hsa04911	2.05833190
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96063929
10	Phototransduction_Homo sapiens_hsa04744	1.91048229
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87721090
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.65806053
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.64538160
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.55162747
15	Butanoate metabolism_Homo sapiens_hsa00650	1.54666814
16	Retinol metabolism_Homo sapiens_hsa00830	1.54431983
17	Renin secretion_Homo sapiens_hsa04924	1.50115391
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.48819962
19	Parkinsons disease_Homo sapiens_hsa05012	1.48543306
20	Circadian rhythm_Homo sapiens_hsa04710	1.42024835
21	Peroxisome_Homo sapiens_hsa04146	1.40861554
22	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.39273473
23	Bile secretion_Homo sapiens_hsa04976	1.37654544
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.33432060
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.29598738
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.26774515
27	Serotonergic synapse_Homo sapiens_hsa04726	1.25101088
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23760688
29	Circadian entrainment_Homo sapiens_hsa04713	1.23030902
30	Morphine addiction_Homo sapiens_hsa05032	1.19583647
31	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.16957336
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.15709681
33	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.15475015
34	Glucagon signaling pathway_Homo sapiens_hsa04922	1.15168556
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14383873
36	Gastric acid secretion_Homo sapiens_hsa04971	1.14295677
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13247270
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12229925
39	Basal transcription factors_Homo sapiens_hsa03022	1.08271060
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.06486920
41	Nicotine addiction_Homo sapiens_hsa05033	1.03969899
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.03937508
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.03702971
44	GABAergic synapse_Homo sapiens_hsa04727	1.03401252
45	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.02391522
46	Dopaminergic synapse_Homo sapiens_hsa04728	1.01881823
47	Sulfur metabolism_Homo sapiens_hsa00920	1.01758092
48	Cocaine addiction_Homo sapiens_hsa05030	1.00923299
49	Regulation of autophagy_Homo sapiens_hsa04140	0.96562080
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95120048
51	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.93435466
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91943529
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88296740
54	Huntingtons disease_Homo sapiens_hsa05016	0.86954381
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.86270490
56	Salivary secretion_Homo sapiens_hsa04970	0.86080242
57	Amphetamine addiction_Homo sapiens_hsa05031	0.84695695
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.84259084
59	ABC transporters_Homo sapiens_hsa02010	0.82742691
60	Fatty acid elongation_Homo sapiens_hsa00062	0.80888477
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.80692881
62	Protein export_Homo sapiens_hsa03060	0.78628860
63	Olfactory transduction_Homo sapiens_hsa04740	0.77965575
64	Arginine biosynthesis_Homo sapiens_hsa00220	0.73735710
65	Ribosome_Homo sapiens_hsa03010	0.73517290
66	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.73050725
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.72853798
68	Rheumatoid arthritis_Homo sapiens_hsa05323	0.70033732
69	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.69176120
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.68769580
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.68707468
72	Propanoate metabolism_Homo sapiens_hsa00640	0.67478524
73	Taste transduction_Homo sapiens_hsa04742	0.64714960
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.64099201
75	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.62402488
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62388518
77	Alzheimers disease_Homo sapiens_hsa05010	0.61958959
78	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.61053073
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.58257013
80	Cholinergic synapse_Homo sapiens_hsa04725	0.57106856
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53137405
82	Primary immunodeficiency_Homo sapiens_hsa05340	0.52199839
83	Gap junction_Homo sapiens_hsa04540	0.52027742
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51602681
85	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50564086
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.49887975
87	Axon guidance_Homo sapiens_hsa04360	0.49640098
88	GnRH signaling pathway_Homo sapiens_hsa04912	0.48897461
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48725510
90	Metabolic pathways_Homo sapiens_hsa01100	0.48169465
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46064927
92	Fatty acid degradation_Homo sapiens_hsa00071	0.44581787
93	Pancreatic secretion_Homo sapiens_hsa04972	0.42818016
94	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.41096546
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40438912
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38894171
97	Melanogenesis_Homo sapiens_hsa04916	0.36769834
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36752326
99	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.36537453
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36094149

UBE2V2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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