UBE2V2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.00465425
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.72336718
3ATP synthesis coupled proton transport (GO:0015986)6.72336718
4negative regulation of heart rate (GO:0010459)6.66649726
5membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.58489948
6regulation of hypersensitivity (GO:0002883)6.52379358
7neuronal action potential propagation (GO:0019227)6.40168661
8positive regulation of protein homodimerization activity (GO:0090073)6.13796143
9potassium ion export (GO:0071435)6.09330619
10membrane repolarization during action potential (GO:0086011)5.79614089
11platelet dense granule organization (GO:0060155)5.70251184
12positive regulation of mast cell activation involved in immune response (GO:0033008)5.44230747
13positive regulation of mast cell degranulation (GO:0043306)5.44230747
14positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.38629098
15negative regulation of calcium ion transport into cytosol (GO:0010523)5.33577883
16preassembly of GPI anchor in ER membrane (GO:0016254)5.07235789
17positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.01248068
18hepatocyte differentiation (GO:0070365)4.77196510
19response to vitamin E (GO:0033197)4.75111122
20spermatid nucleus differentiation (GO:0007289)4.70288779
21pyrimidine nucleobase catabolic process (GO:0006208)4.70042867
22regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.59201913
23regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.55582965
24positive regulation of leukocyte degranulation (GO:0043302)4.49928226
25negative regulation of phosphoprotein phosphatase activity (GO:0032515)4.45542854
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.40352475
27positive regulation of mast cell activation (GO:0033005)4.38389795
28protein maturation by protein folding (GO:0022417)4.37007161
29acrosome assembly (GO:0001675)4.20392525
30membrane repolarization (GO:0086009)4.17402317
31positive regulation of potassium ion transmembrane transport (GO:1901381)4.08932990
32nucleobase catabolic process (GO:0046113)4.06630080
33dopamine transport (GO:0015872)4.06331921
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.05666953
35monoamine transport (GO:0015844)3.97447419
36sarcoplasmic reticulum calcium ion transport (GO:0070296)3.95397182
37negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.93315830
38negative regulation of mast cell activation (GO:0033004)3.92147977
39neurotransmitter uptake (GO:0001504)3.91408637
40ATP biosynthetic process (GO:0006754)3.90534091
41behavioral response to nicotine (GO:0035095)3.90248754
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.87370648
43respiratory electron transport chain (GO:0022904)3.86211522
44electron transport chain (GO:0022900)3.82946430
45protein refolding (GO:0042026)3.77468822
46synaptic transmission, cholinergic (GO:0007271)3.75079689
47postsynaptic membrane organization (GO:0001941)3.74840894
48positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.63115244
49positive regulation of cellular response to oxidative stress (GO:1900409)3.57500627
50positive regulation of response to oxidative stress (GO:1902884)3.57500627
51mitochondrial genome maintenance (GO:0000002)3.53411069
52GPI anchor biosynthetic process (GO:0006506)3.52427000
53regulation of neuron projection regeneration (GO:0070570)3.47253598
54regulation of axon regeneration (GO:0048679)3.47253598
55axonemal dynein complex assembly (GO:0070286)3.43826016
56kynurenine metabolic process (GO:0070189)3.41769590
57positive regulation of T cell cytokine production (GO:0002726)3.41595183
58forebrain neuron differentiation (GO:0021879)3.39764522
59calcium-mediated signaling using intracellular calcium source (GO:0035584)3.38263106
60positive regulation of regulated secretory pathway (GO:1903307)3.36022584
61centriole replication (GO:0007099)3.31677173
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31225491
63sequestering of actin monomers (GO:0042989)3.31021224
64interkinetic nuclear migration (GO:0022027)3.24506149
65GPI anchor metabolic process (GO:0006505)3.22691978
66regulation of oxidative stress-induced neuron death (GO:1903203)3.18329770
67protein localization to cilium (GO:0061512)3.18087453
68positive regulation of vesicle fusion (GO:0031340)3.17679229
69lactate metabolic process (GO:0006089)3.15040299
70chaperone-mediated protein transport (GO:0072321)3.14495322
71DNA double-strand break processing (GO:0000729)3.14119381
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.05716548
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02569340
74response to redox state (GO:0051775)3.00934203
75protein peptidyl-prolyl isomerization (GO:0000413)3.00714597
76protein polyglutamylation (GO:0018095)2.94481180
77regulation of membrane repolarization (GO:0060306)2.94421870
78purine nucleoside triphosphate biosynthetic process (GO:0009145)2.92741837
79cell communication by electrical coupling (GO:0010644)2.90131966
80microtubule anchoring (GO:0034453)2.90031559
81epithelial cilium movement (GO:0003351)2.89555760
82response to lipoprotein particle (GO:0055094)2.89347412
83regulation of mast cell activation (GO:0033003)2.87491174
84protein localization to synapse (GO:0035418)2.84348877
85forebrain morphogenesis (GO:0048853)2.83348398
86cell morphogenesis involved in neuron differentiation (GO:0048667)2.83133856
87galactose catabolic process (GO:0019388)2.81279000
88negative regulation of cation channel activity (GO:2001258)2.79879971
89regulation of autophagic vacuole assembly (GO:2000785)2.78341024
90axoneme assembly (GO:0035082)2.75653465
91positive regulation of transcription regulatory region DNA binding (GO:2000679)2.74692263
92endocrine hormone secretion (GO:0060986)2.70247050
93hydrogen ion transmembrane transport (GO:1902600)2.69240137
94negative regulation of axon extension involved in axon guidance (GO:0048843)2.67637797
95aldehyde catabolic process (GO:0046185)2.66888779
96negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.65797118
97negative regulation of calcium ion transmembrane transport (GO:1903170)2.65797118
98positive regulation of steroid hormone secretion (GO:2000833)2.65764778
99prenylation (GO:0097354)2.62050527
100protein prenylation (GO:0018342)2.62050527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF15_26573619_Chip-Seq_HEK293_Human4.57504597
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.72879244
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.34142125
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17703612
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.81081285
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.76636829
7EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.59009580
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.52882630
9ZNF274_21170338_ChIP-Seq_K562_Hela2.43367224
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.37753466
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.30162495
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19558343
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15008259
14P300_19829295_ChIP-Seq_ESCs_Human2.08996338
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.07511948
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.01320502
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96886630
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96508328
19ELK1_19687146_ChIP-ChIP_HELA_Human1.95373153
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91149383
21EWS_26573619_Chip-Seq_HEK293_Human1.90174047
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89831736
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.88266175
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.81918551
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77946520
26EZH2_22144423_ChIP-Seq_EOC_Human1.77422582
27SOX2_16153702_ChIP-ChIP_HESCs_Human1.76891683
28ER_23166858_ChIP-Seq_MCF-7_Human1.75317856
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73029032
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.68228360
31RNF2_27304074_Chip-Seq_NSC_Mouse1.61560856
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61061214
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56080691
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52170353
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50975846
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50666929
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48449214
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46770430
39AR_21572438_ChIP-Seq_LNCaP_Human1.46301703
40MYC_18940864_ChIP-ChIP_HL60_Human1.44835984
41HTT_18923047_ChIP-ChIP_STHdh_Human1.44546974
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.42293447
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37569110
44VDR_23849224_ChIP-Seq_CD4+_Human1.36157911
45ERG_20517297_ChIP-Seq_VCAP_Human1.33571230
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32494638
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32203308
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.30208360
49SOX2_19829295_ChIP-Seq_ESCs_Human1.28486004
50NANOG_19829295_ChIP-Seq_ESCs_Human1.28486004
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28226877
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27320602
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.27320602
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.26683681
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.26093749
56VDR_22108803_ChIP-Seq_LS180_Human1.22510555
57AR_25329375_ChIP-Seq_VCAP_Human1.20353372
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18684097
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.18361026
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16498360
61SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14552786
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.14133566
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.13846903
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12085953
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12085953
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11931779
67FUS_26573619_Chip-Seq_HEK293_Human1.11795666
68NCOR_22424771_ChIP-Seq_293T_Human1.11233403
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10868254
70P300_18555785_Chip-Seq_ESCs_Mouse1.09813993
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.09539523
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07827363
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.06763217
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06369860
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05835200
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05611152
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.04563059
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04519285
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.04063617
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03259731
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02641168
82P53_22387025_ChIP-Seq_ESCs_Mouse1.02407158
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02377116
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02366524
85CIITA_25753668_ChIP-Seq_RAJI_Human1.01635625
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.00334736
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00169338
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99938226
89RBPJ_21746931_ChIP-Seq_IB4_Human0.98144241
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98110725
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97444631
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97277864
93SOX2_18555785_Chip-Seq_ESCs_Mouse0.96138709
94TP53_22573176_ChIP-Seq_HFKS_Human0.95651195
95AR_20517297_ChIP-Seq_VCAP_Human0.95629316
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95344440
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95328002
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95321816
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94721657
100REST_21632747_ChIP-Seq_MESCs_Mouse0.93720287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology6.15162938
2MP0005377_hearing/vestibular/ear_phenot6.15162938
3MP0002102_abnormal_ear_morphology3.79043674
4MP0001485_abnormal_pinna_reflex3.10211019
5MP0005084_abnormal_gallbladder_morpholo3.02657667
6MP0006292_abnormal_olfactory_placode2.83481380
7MP0003787_abnormal_imprinting2.55180884
8MP0003122_maternal_imprinting2.52935876
9MP0006276_abnormal_autonomic_nervous2.46239151
10MP0004147_increased_porphyrin_level2.43363747
11MP0003136_yellow_coat_color2.41471485
12MP0008961_abnormal_basal_metabolism2.24919949
13MP0001919_abnormal_reproductive_system2.24476228
14MP0009046_muscle_twitch2.12890688
15MP0003137_abnormal_impulse_conducting2.02194914
16MP0005187_abnormal_penis_morphology1.95013667
17MP0005423_abnormal_somatic_nervous1.83411783
18MP0008995_early_reproductive_senescence1.80501800
19MP0003724_increased_susceptibility_to1.80025136
20MP0003880_abnormal_central_pattern1.78593560
21MP0003121_genomic_imprinting1.76284713
22MP0005645_abnormal_hypothalamus_physiol1.74806031
23MP0008872_abnormal_physiological_respon1.67443179
24MP0006072_abnormal_retinal_apoptosis1.66632858
25MP0004142_abnormal_muscle_tone1.65517338
26MP0000778_abnormal_nervous_system1.62634226
27MP0000631_abnormal_neuroendocrine_gland1.54261439
28MP0002751_abnormal_autonomic_nervous1.51046324
29MP0002735_abnormal_chemical_nociception1.46659957
30MP0002928_abnormal_bile_duct1.43142671
31MP0001286_abnormal_eye_development1.41984351
32MP0000372_irregular_coat_pigmentation1.38289287
33MP0000026_abnormal_inner_ear1.35104373
34MP0002067_abnormal_sensory_capabilities1.33229418
35MP0005367_renal/urinary_system_phenotyp1.33032421
36MP0000516_abnormal_urinary_system1.33032421
37MP0005389_reproductive_system_phenotype1.31803336
38MP0008877_abnormal_DNA_methylation1.30267035
39MP0003221_abnormal_cardiomyocyte_apopto1.27192237
40MP0000647_abnormal_sebaceous_gland1.24177429
41MP0005253_abnormal_eye_physiology1.24166632
42MP0009745_abnormal_behavioral_response1.20626145
43MP0004215_abnormal_myocardial_fiber1.20046694
44MP0002160_abnormal_reproductive_system1.18210010
45MP0001486_abnormal_startle_reflex1.17915281
46MP0003879_abnormal_hair_cell1.15431692
47MP0003786_premature_aging1.15201855
48MP0003195_calcinosis1.15002016
49MP0001963_abnormal_hearing_physiology1.09949390
50MP0001661_extended_life_span1.06506253
51MP0003635_abnormal_synaptic_transmissio1.05515122
52MP0002557_abnormal_social/conspecific_i1.05478096
53MP0002064_seizures1.05147562
54MP0004270_analgesia1.04762899
55MP0006054_spinal_hemorrhage1.02038808
56MP0002184_abnormal_innervation0.99297284
57MP0001905_abnormal_dopamine_level0.96570164
58MP0009333_abnormal_splenocyte_physiolog0.92876834
59MP0002752_abnormal_somatic_nervous0.92428271
60MP0001765_abnormal_ion_homeostasis0.89851973
61MP0002272_abnormal_nervous_system0.88432804
62MP0002277_abnormal_respiratory_mucosa0.88087973
63MP0001835_abnormal_antigen_presentation0.87531113
64MP0002229_neurodegeneration0.84088036
65MP0002882_abnormal_neuron_morphology0.83955998
66MP0008775_abnormal_heart_ventricle0.83338690
67MP0000579_abnormal_nail_morphology0.83257127
68MP0002822_catalepsy0.83055762
69MP0001800_abnormal_humoral_immune0.82238581
70MP0005386_behavior/neurological_phenoty0.79271270
71MP0004924_abnormal_behavior0.79271270
72MP0002063_abnormal_learning/memory/cond0.78830616
73MP0002638_abnormal_pupillary_reflex0.77618468
74MP0000343_altered_response_to0.77455829
75MP0005195_abnormal_posterior_eye0.76165329
76MP0003633_abnormal_nervous_system0.75304692
77MP0002572_abnormal_emotion/affect_behav0.75023737
78MP0005636_abnormal_mineral_homeostasis0.75022851
79MP0001293_anophthalmia0.72774618
80MP0001502_abnormal_circadian_rhythm0.72716271
81MP0005391_vision/eye_phenotype0.69980290
82MP0001970_abnormal_pain_threshold0.69760259
83MP0001663_abnormal_digestive_system0.66317027
84MP0006035_abnormal_mitochondrial_morpho0.64833488
85MP0000955_abnormal_spinal_cord0.64797452
86MP0000685_abnormal_immune_system0.64169496
87MP0004043_abnormal_pH_regulation0.63289714
88MP0003329_amyloid_beta_deposits0.62624004
89MP0004085_abnormal_heartbeat0.62440400
90MP0002069_abnormal_eating/drinking_beha0.61933289
91MP0004742_abnormal_vestibular_system0.61495307
92MP0002972_abnormal_cardiac_muscle0.61261204
93MP0004484_altered_response_of0.60404850
94MP0010307_abnormal_tumor_latency0.60281429
95MP0004811_abnormal_neuron_physiology0.60254796
96MP0002234_abnormal_pharynx_morphology0.58332806
97MP0005551_abnormal_eye_electrophysiolog0.56553179
98MP0002152_abnormal_brain_morphology0.55787176
99MP0005499_abnormal_olfactory_system0.55667919
100MP0005394_taste/olfaction_phenotype0.55667919

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.32553296
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.32553296
3Abnormality of the corticospinal tract (HP:0002492)5.35281271
4Large eyes (HP:0001090)5.14593616
5Lipid accumulation in hepatocytes (HP:0006561)4.80200049
6Insidious onset (HP:0003587)4.77925958
7Termporal pattern (HP:0011008)4.77925958
8Increased hepatocellular lipid droplets (HP:0006565)4.73706427
9Chronic sinusitis (HP:0011109)4.43404626
10Urinary bladder sphincter dysfunction (HP:0002839)3.91033594
11Azoospermia (HP:0000027)3.80287527
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.68415631
13Absent/shortened dynein arms (HP:0200106)3.68415631
14Ventricular fibrillation (HP:0001663)3.63794863
15Abnormal ciliary motility (HP:0012262)3.56518278
16Impaired vibration sensation in the lower limbs (HP:0002166)3.52042154
17Methylmalonic acidemia (HP:0002912)3.46421069
18Renal Fanconi syndrome (HP:0001994)3.29557571
19Arthropathy (HP:0003040)3.21346354
20Exertional dyspnea (HP:0002875)3.19561113
21Abnormal respiratory motile cilium morphology (HP:0005938)3.16556060
22Abnormal respiratory epithelium morphology (HP:0012253)3.16556060
23Abnormal respiratory motile cilium physiology (HP:0012261)3.09160679
24Morphological abnormality of the pyramidal tract (HP:0002062)3.07453725
25Supernumerary spleens (HP:0009799)3.07258945
26Increased intramyocellular lipid droplets (HP:0012240)2.99617945
27Urinary urgency (HP:0000012)2.92042621
28Type II lissencephaly (HP:0007260)2.90206021
29Increased muscle lipid content (HP:0009058)2.80949971
30Increased CSF lactate (HP:0002490)2.75791206
31Hyperphosphaturia (HP:0003109)2.70267752
32Birth length less than 3rd percentile (HP:0003561)2.68945061
33Congenital, generalized hypertrichosis (HP:0004540)2.65829558
34Prolonged QT interval (HP:0001657)2.59087020
35Anteriorly placed anus (HP:0001545)2.56458217
36Mitochondrial inheritance (HP:0001427)2.53739602
37Abnormal spermatogenesis (HP:0008669)2.51627499
38Brittle hair (HP:0002299)2.50414192
39Septo-optic dysplasia (HP:0100842)2.45770535
40Syncope (HP:0001279)2.43432103
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38506447
42Medulloblastoma (HP:0002885)2.36722612
43Hypomagnesemia (HP:0002917)2.34156737
44Volvulus (HP:0002580)2.33449712
45Abnormality of urine glucose concentration (HP:0011016)2.25378986
46Glycosuria (HP:0003076)2.25378986
47Renal tubular dysfunction (HP:0000124)2.24735914
48Optic nerve hypoplasia (HP:0000609)2.24352325
49Decreased subcutaneous fat (HP:0001002)2.19786360
50Intestinal atresia (HP:0011100)2.17822317
51Methylmalonic aciduria (HP:0012120)2.16836629
52Long nose (HP:0003189)2.15856229
53Tented upper lip vermilion (HP:0010804)2.15575035
54Hemivertebrae (HP:0002937)2.13752321
55Polyphagia (HP:0002591)2.13229594
56Respiratory difficulties (HP:0002880)2.12957699
57Breast hypoplasia (HP:0003187)2.12681890
58Acute necrotizing encephalopathy (HP:0006965)2.12226981
59Abnormal urine phosphate concentration (HP:0012599)2.09196193
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08515691
61Bilateral microphthalmos (HP:0007633)2.08184975
62Lissencephaly (HP:0001339)2.07894375
63Cerebellar dysplasia (HP:0007033)2.06801708
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05369668
65Autoamputation (HP:0001218)2.04536329
66B lymphocytopenia (HP:0010976)2.03220295
67Abnormality of magnesium homeostasis (HP:0004921)2.02386010
68Fragile nails (HP:0001808)1.99369019
69Mutism (HP:0002300)1.98968063
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98032167
71Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98032167
72Double outlet right ventricle (HP:0001719)1.97558968
73Congenital malformation of the right heart (HP:0011723)1.97558968
74True hermaphroditism (HP:0010459)1.96241984
75Impaired vibratory sensation (HP:0002495)1.95348823
76Abnormality of renal resorption (HP:0011038)1.94464079
77Abnormality of the vitamin B12 metabolism (HP:0004341)1.93746816
78Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90738656
79Hypoplasia of the brainstem (HP:0002365)1.90738656
80Abnormality of homocysteine metabolism (HP:0010919)1.86862261
81Homocystinuria (HP:0002156)1.86862261
82Genetic anticipation (HP:0003743)1.85264854
833-Methylglutaconic aciduria (HP:0003535)1.84746566
84Large for gestational age (HP:0001520)1.82117935
85Tetany (HP:0001281)1.81364705
86Delayed closure of the anterior fontanelle (HP:0001476)1.80371965
87Tubular atrophy (HP:0000092)1.80328224
88Oligodactyly (hands) (HP:0001180)1.80301265
89Muscle hypertrophy of the lower extremities (HP:0008968)1.80097506
90Abnormality of vitamin B metabolism (HP:0004340)1.79883076
91Abnormal mitochondria in muscle tissue (HP:0008316)1.79778124
92Progressive macrocephaly (HP:0004481)1.78774996
93Testicular atrophy (HP:0000029)1.76766953
94Limb dystonia (HP:0002451)1.75523100
95Lower limb muscle weakness (HP:0007340)1.74876400
96Pachygyria (HP:0001302)1.74075885
97Absent speech (HP:0001344)1.73997362
98Calf muscle hypertrophy (HP:0008981)1.73035029
99Partial agenesis of the corpus callosum (HP:0001338)1.72687049
100Abnormality of B cell number (HP:0010975)1.72165177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.74284448
2SCYL24.30360339
3TLK13.48358089
4ERBB33.45496287
5BMPR23.32791030
6NEK23.16937026
7ZAK2.52672096
8CASK2.51870628
9TRPM72.28637567
10MAP4K22.20464404
11MAP3K42.20012793
12GRK12.06601531
13NTRK11.77075794
14CDK191.65009726
15ADRBK21.63535454
16MARK11.62468883
17TNIK1.52930923
18TYRO31.51641541
19MAP2K71.48405569
20FES1.48245977
21MAP3K61.47446286
22MAPK151.40989368
23BUB11.39094702
24NLK1.38287052
25PLK21.33256392
26CAMKK21.28297781
27VRK11.27333709
28MYLK1.23988364
29WEE11.23179154
30PLK41.13037813
31MINK11.10742565
32EPHA31.07806908
33NEK11.06693844
34ILK1.06373542
35NUAK11.05515258
36PHKG21.04351379
37PHKG11.04351379
38BCR1.01263288
39PLK30.98620116
40PNCK0.97294712
41PINK10.96589421
42AURKB0.95433545
43FER0.94122836
44ALK0.91799707
45MAP2K40.90709808
46NTRK20.87242433
47EIF2AK20.86271920
48CCNB10.84756098
49MAPKAPK30.83753789
50EIF2AK30.82828406
51DYRK20.79428106
52DYRK1B0.78086086
53BMPR1B0.74449488
54GRK60.74009546
55MAP3K50.73082731
56WNK10.71884291
57PRKCG0.67635317
58ROCK10.67250024
59JAK10.67121280
60PKN10.66974888
61CSNK1G20.66396137
62CSNK1A1L0.66018448
63WNK40.62598329
64HCK0.61820138
65TAOK30.61391865
66FRK0.59159584
67CSNK1G30.58506995
68MKNK20.58240852
69EPHB20.56412657
70CSNK1G10.56391786
71WNK30.56001305
72MAP3K110.54875961
73DMPK0.54103261
74ERBB20.53186872
75RPS6KA50.47935595
76MAP2K60.46891355
77PTK60.46867225
78TRIM280.46107687
79STK110.45649312
80DAPK20.45567637
81PRKG10.44295794
82OXSR10.42248239
83INSRR0.41914839
84MATK0.41225714
85NEK90.37868029
86ADRBK10.37703256
87PTK2B0.36606924
88PRKACA0.32828332
89CDK140.32398741
90MAPK120.32000515
91PRKCQ0.30597925
92MARK30.29633018
93DAPK30.28839923
94EIF2AK10.26254363
95ROCK20.25981128
96EPHB10.24828601
97PRKACG0.24125539
98EPHA40.23967547
99MAPK130.23702833
100PRKCA0.23449394

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.88193971
2Asthma_Homo sapiens_hsa053104.45455267
3Parkinsons disease_Homo sapiens_hsa050124.28321964
4Alzheimers disease_Homo sapiens_hsa050103.24343006
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.92156013
6Huntingtons disease_Homo sapiens_hsa050162.64800020
7Cardiac muscle contraction_Homo sapiens_hsa042602.59500025
8Proteasome_Homo sapiens_hsa030502.49748315
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.35202202
10Type I diabetes mellitus_Homo sapiens_hsa049402.19726316
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19514614
12Systemic lupus erythematosus_Homo sapiens_hsa053221.98226168
13Homologous recombination_Homo sapiens_hsa034401.98191975
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95375719
15Butanoate metabolism_Homo sapiens_hsa006501.94945168
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92721031
17Autoimmune thyroid disease_Homo sapiens_hsa053201.87680565
18Graft-versus-host disease_Homo sapiens_hsa053321.80987294
19Allograft rejection_Homo sapiens_hsa053301.77906590
20Protein export_Homo sapiens_hsa030601.76686302
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.58887743
22Alcoholism_Homo sapiens_hsa050341.46833669
23Dorso-ventral axis formation_Homo sapiens_hsa043201.43671024
24Nitrogen metabolism_Homo sapiens_hsa009101.41092078
25Selenocompound metabolism_Homo sapiens_hsa004501.40506839
26GABAergic synapse_Homo sapiens_hsa047271.35030849
27Nicotine addiction_Homo sapiens_hsa050331.34730247
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34429288
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11447960
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09649967
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06403781
32Ribosome_Homo sapiens_hsa030101.04007964
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02910203
34Collecting duct acid secretion_Homo sapiens_hsa049661.00193096
35Dopaminergic synapse_Homo sapiens_hsa047280.92484847
36Viral myocarditis_Homo sapiens_hsa054160.91693018
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90235354
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88932660
39Oocyte meiosis_Homo sapiens_hsa041140.88456269
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86724968
41Tryptophan metabolism_Homo sapiens_hsa003800.84664608
42Morphine addiction_Homo sapiens_hsa050320.83665738
43RNA polymerase_Homo sapiens_hsa030200.82835424
44Rheumatoid arthritis_Homo sapiens_hsa053230.79413217
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77110392
46Circadian entrainment_Homo sapiens_hsa047130.75850358
47Malaria_Homo sapiens_hsa051440.73522967
48Glutamatergic synapse_Homo sapiens_hsa047240.70750329
49Amphetamine addiction_Homo sapiens_hsa050310.70403151
50Leishmaniasis_Homo sapiens_hsa051400.66837576
51Hippo signaling pathway_Homo sapiens_hsa043900.65319960
52Synaptic vesicle cycle_Homo sapiens_hsa047210.61919848
53Basal transcription factors_Homo sapiens_hsa030220.61185467
54Chemical carcinogenesis_Homo sapiens_hsa052040.60557074
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59428497
56Regulation of autophagy_Homo sapiens_hsa041400.58487488
57Staphylococcus aureus infection_Homo sapiens_hsa051500.57679999
58Tuberculosis_Homo sapiens_hsa051520.57021609
59beta-Alanine metabolism_Homo sapiens_hsa004100.56392021
60Gastric acid secretion_Homo sapiens_hsa049710.55817740
61Phototransduction_Homo sapiens_hsa047440.55702836
62Antigen processing and presentation_Homo sapiens_hsa046120.54875035
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54625706
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54380637
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53225593
66Basal cell carcinoma_Homo sapiens_hsa052170.52330853
67p53 signaling pathway_Homo sapiens_hsa041150.51639757
68Starch and sucrose metabolism_Homo sapiens_hsa005000.49827002
69Salmonella infection_Homo sapiens_hsa051320.48752716
70Serotonergic synapse_Homo sapiens_hsa047260.46147916
71Peroxisome_Homo sapiens_hsa041460.45430539
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.42090009
73Spliceosome_Homo sapiens_hsa030400.41591733
74Axon guidance_Homo sapiens_hsa043600.41277842
75Phagosome_Homo sapiens_hsa041450.37889065
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36674461
77Salivary secretion_Homo sapiens_hsa049700.36504498
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.34030807
79Fanconi anemia pathway_Homo sapiens_hsa034600.31797426
80Olfactory transduction_Homo sapiens_hsa047400.31494263
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31025419
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29517770
83RNA degradation_Homo sapiens_hsa030180.29304487
84Glutathione metabolism_Homo sapiens_hsa004800.28309185
85T cell receptor signaling pathway_Homo sapiens_hsa046600.28298375
86Wnt signaling pathway_Homo sapiens_hsa043100.28116449
87Insulin secretion_Homo sapiens_hsa049110.24126344
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23672666
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23284932
90Toxoplasmosis_Homo sapiens_hsa051450.22872464
91African trypanosomiasis_Homo sapiens_hsa051430.22715295
92Cholinergic synapse_Homo sapiens_hsa047250.21885274
93Metabolic pathways_Homo sapiens_hsa011000.20897758
94Hedgehog signaling pathway_Homo sapiens_hsa043400.20599922
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19293406
96ABC transporters_Homo sapiens_hsa020100.18776509
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18726136
98Oxytocin signaling pathway_Homo sapiens_hsa049210.18153146
99Linoleic acid metabolism_Homo sapiens_hsa005910.17098706
100Epstein-Barr virus infection_Homo sapiens_hsa051690.13621971

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »