ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of interleukin-5 production (GO:0032674)	5.89079857
2	piRNA metabolic process (GO:0034587)	4.75953842
3	axoneme assembly (GO:0035082)	4.59558647
4	protein-cofactor linkage (GO:0018065)	4.26358838
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.10002761
6	nephron epithelium morphogenesis (GO:0072088)	4.03469935
7	nephron tubule morphogenesis (GO:0072078)	4.03469935
8	proline transport (GO:0015824)	4.02922425
9	cellular ketone body metabolic process (GO:0046950)	4.01489600
10	behavioral response to nicotine (GO:0035095)	3.98550313
11	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.92370648
12	protein complex biogenesis (GO:0070271)	3.74626122
13	C-terminal protein lipidation (GO:0006501)	3.68206807
14	regulation of neurotransmitter uptake (GO:0051580)	3.67819550
15	regulation of cilium movement (GO:0003352)	3.53986522
16	ketone body metabolic process (GO:1902224)	3.53476885
17	DNA methylation involved in gamete generation (GO:0043046)	3.53002506
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.46292378
19	NADH dehydrogenase complex assembly (GO:0010257)	3.46292378
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.46292378
21	C-terminal protein amino acid modification (GO:0018410)	3.42295060
22	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.40841745
23	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.40841745
24	nucleotide transmembrane transport (GO:1901679)	3.40179204
25	transmission of nerve impulse (GO:0019226)	3.34909724
26	signal peptide processing (GO:0006465)	3.34658932
27	protein neddylation (GO:0045116)	3.30483732
28	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.30152367
29	cellular response to ATP (GO:0071318)	3.29225260
30	adenosine metabolic process (GO:0046085)	3.28615685
31	respiratory chain complex IV assembly (GO:0008535)	3.18572641
32	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18388294
33	renal tubule morphogenesis (GO:0061333)	3.16810047
34	preassembly of GPI anchor in ER membrane (GO:0016254)	3.10705808
35	S-adenosylmethionine metabolic process (GO:0046500)	3.10602468
36	chaperone-mediated protein transport (GO:0072321)	3.09768141
37	gamma-aminobutyric acid transport (GO:0015812)	3.08607188
38	eating behavior (GO:0042755)	3.08415337
39	protein polyglutamylation (GO:0018095)	3.08381396
40	ubiquinone biosynthetic process (GO:0006744)	3.08113297
41	rRNA methylation (GO:0031167)	3.07874704
42	nonmotile primary cilium assembly (GO:0035058)	3.03939721
43	prostate gland growth (GO:0060736)	3.03764091
44	positive regulation of mitochondrial fission (GO:0090141)	2.97920189
45	retinal ganglion cell axon guidance (GO:0031290)	2.96810559
46	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.96765001
47	mannosylation (GO:0097502)	2.95650792
48	brain morphogenesis (GO:0048854)	2.94260769
49	positive regulation of glycolytic process (GO:0045821)	2.93895199
50	dendritic spine morphogenesis (GO:0060997)	2.93160642
51	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.92216475
52	male sex determination (GO:0030238)	2.89775795
53	positive regulation of meiosis (GO:0045836)	2.89508798
54	inositol phosphate catabolic process (GO:0071545)	2.87843492
55	cell differentiation involved in metanephros development (GO:0072202)	2.87112102
56	female gonad development (GO:0008585)	2.86919878
57	detection of light stimulus involved in visual perception (GO:0050908)	2.82852124
58	detection of light stimulus involved in sensory perception (GO:0050962)	2.82852124
59	phosphorelay signal transduction system (GO:0000160)	2.82848669
60	mechanosensory behavior (GO:0007638)	2.81638545
61	rRNA modification (GO:0000154)	2.81370230
62	ubiquinone metabolic process (GO:0006743)	2.74321434
63	auditory behavior (GO:0031223)	2.74067539
64	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.73677114
65	oxidative demethylation (GO:0070989)	2.71064579
66	sex determination (GO:0007530)	2.69513995
67	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.68827168
68	inositol phosphate dephosphorylation (GO:0046855)	2.68827168
69	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.68674778
70	neural tube formation (GO:0001841)	2.68034448
71	protein K6-linked ubiquitination (GO:0085020)	2.67246020
72	positive regulation of meiotic cell cycle (GO:0051446)	2.66763196
73	reflex (GO:0060004)	2.66360142
74	protein K11-linked ubiquitination (GO:0070979)	2.63904274
75	quinone biosynthetic process (GO:1901663)	2.60938509
76	cytochrome complex assembly (GO:0017004)	2.59989241
77	head development (GO:0060322)	2.59504531
78	DNA deamination (GO:0045006)	2.59026663
79	male meiosis (GO:0007140)	2.58599766
80	organelle disassembly (GO:1903008)	2.57805466
81	embryonic epithelial tube formation (GO:0001838)	2.57106020
82	response to redox state (GO:0051775)	2.56288237
83	epithelial cilium movement (GO:0003351)	2.54815592
84	spinal cord association neuron differentiation (GO:0021527)	2.53204649
85	cilium morphogenesis (GO:0060271)	2.52549535
86	protein deneddylation (GO:0000338)	2.51862860
87	cardiac right ventricle morphogenesis (GO:0003215)	2.50999900
88	response to pheromone (GO:0019236)	2.50347880
89	cullin deneddylation (GO:0010388)	2.50149225
90	glandular epithelial cell differentiation (GO:0002067)	2.49790561
91	platelet dense granule organization (GO:0060155)	2.49373728
92	microtubule nucleation (GO:0007020)	2.48839027
93	regulation of male gonad development (GO:2000018)	2.48679546
94	regulation of microtubule-based movement (GO:0060632)	2.48570183
95	dicarboxylic acid catabolic process (GO:0043649)	2.46446720
96	maturation of SSU-rRNA (GO:0030490)	2.45204324
97	positive regulation of prostaglandin secretion (GO:0032308)	2.44272662
98	dentate gyrus development (GO:0021542)	2.43467604
99	negative regulation of hormone biosynthetic process (GO:0032353)	2.43364610
100	potassium ion export (GO:0071435)	2.42626107

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.59077623
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.72955553
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.71204401
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.55465320
5	TP53_22573176_ChIP-Seq_HFKS_Human	2.41570668
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40737777
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36868353
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.33233480
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.25710938
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04894725
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.01998213
12	GBX2_23144817_ChIP-Seq_PC3_Human	1.99769687
13	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.95521003
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.93621172
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.89450014
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.88307638
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.87786268
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85444840
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85307146
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.85197607
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.82531132
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80900146
23	P300_19829295_ChIP-Seq_ESCs_Human	1.78082827
24	EWS_26573619_Chip-Seq_HEK293_Human	1.76964814
25	FUS_26573619_Chip-Seq_HEK293_Human	1.75911913
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71202000
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59772207
28	VDR_22108803_ChIP-Seq_LS180_Human	1.58935915
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55352600
30	STAT3_23295773_ChIP-Seq_U87_Human	1.52469815
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46767270
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.45570219
33	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42979693
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42979693
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42863507
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.40072862
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39480938
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39465797
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.38692378
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38340544
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38318779
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36617470
43	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.36294386
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35960530
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33018042
46	TCF4_22108803_ChIP-Seq_LS180_Human	1.32627846
47	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.32618887
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32306834
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31577299
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31250788
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29770408
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29170015
53	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28543114
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.27879390
55	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.27366202
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.27195010
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.26691965
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25903543
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25280378
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24615589
61	TCF4_23295773_ChIP-Seq_U87_Human	1.23472068
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.22990852
63	AR_25329375_ChIP-Seq_VCAP_Human	1.21816886
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20346931
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19824677
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19804337
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19513563
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13702745
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13394166
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.13394166
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12433246
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12102144
73	NCOR_22424771_ChIP-Seq_293T_Human	1.11778667
74	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.09664439
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09336541
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09240452
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08545025
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08545025
79	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.07839001
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07453271
81	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06707231
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06587384
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06587384
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06445474
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.06250072
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05581989
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04525681
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04430746
89	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04233846
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04223963
91	MYC_19829295_ChIP-Seq_ESCs_Human	1.03888006
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03880826
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02991770
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02650538
95	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02433030
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02061428
97	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.00952652
98	AR_20517297_ChIP-Seq_VCAP_Human	1.00876040
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00243686
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00162378

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.09900764
2	MP0003195_calcinosis	3.46234240
3	MP0006072_abnormal_retinal_apoptosis	3.15540238
4	MP0005379_endocrine/exocrine_gland_phen	3.01220236
5	MP0009046_muscle_twitch	2.76786892
6	MP0004142_abnormal_muscle_tone	2.22365226
7	MP0001501_abnormal_sleep_pattern	2.22042733
8	MP0000631_abnormal_neuroendocrine_gland	2.16455164
9	MP0002653_abnormal_ependyma_morphology	2.15201833
10	MP0004147_increased_porphyrin_level	2.09943686
11	MP0002876_abnormal_thyroid_physiology	2.07879169
12	MP0006292_abnormal_olfactory_placode	2.06555934
13	MP0002837_dystrophic_cardiac_calcinosis	2.03937486
14	MP0003122_maternal_imprinting	1.99899264
15	MP0003646_muscle_fatigue	1.99282804
16	MP0003121_genomic_imprinting	1.95632040
17	MP0003787_abnormal_imprinting	1.95412553
18	MP0002163_abnormal_gland_morphology	1.81966203
19	MP0001986_abnormal_taste_sensitivity	1.77153615
20	MP0008995_early_reproductive_senescence	1.73528981
21	MP0002272_abnormal_nervous_system	1.72270134
22	MP0009745_abnormal_behavioral_response	1.72078639
23	MP0001984_abnormal_olfaction	1.68172872
24	MP0006276_abnormal_autonomic_nervous	1.68007924
25	MP0005551_abnormal_eye_electrophysiolog	1.63198670
26	MP0004043_abnormal_pH_regulation	1.62590308
27	MP0003724_increased_susceptibility_to	1.60193014
28	MP0002735_abnormal_chemical_nociception	1.54413387
29	MP0002572_abnormal_emotion/affect_behav	1.51936957
30	MP0005167_abnormal_blood-brain_barrier	1.51925827
31	MP0004859_abnormal_synaptic_plasticity	1.49192705
32	MP0002909_abnormal_adrenal_gland	1.46212315
33	MP0002064_seizures	1.45766790
34	MP0001968_abnormal_touch/_nociception	1.44406801
35	MP0001440_abnormal_grooming_behavior	1.42177720
36	MP0001529_abnormal_vocalization	1.39860092
37	MP0005253_abnormal_eye_physiology	1.36668000
38	MP0005645_abnormal_hypothalamus_physiol	1.36131343
39	MP0003880_abnormal_central_pattern	1.34124637
40	MP0008872_abnormal_physiological_respon	1.31938962
41	MP0005499_abnormal_olfactory_system	1.31783150
42	MP0005394_taste/olfaction_phenotype	1.31783150
43	MP0001970_abnormal_pain_threshold	1.27324108
44	MP0002234_abnormal_pharynx_morphology	1.26843732
45	MP0002638_abnormal_pupillary_reflex	1.25828163
46	MP0002160_abnormal_reproductive_system	1.25529111
47	MP0005389_reproductive_system_phenotype	1.24741657
48	MP0008875_abnormal_xenobiotic_pharmacok	1.24163621
49	MP0000427_abnormal_hair_cycle	1.24160216
50	MP0004145_abnormal_muscle_electrophysio	1.22019644
51	MP0003635_abnormal_synaptic_transmissio	1.18673374
52	MP0004924_abnormal_behavior	1.17082710
53	MP0005386_behavior/neurological_phenoty	1.17082710
54	MP0008789_abnormal_olfactory_epithelium	1.16893407
55	MP0002184_abnormal_innervation	1.16363750
56	MP0004885_abnormal_endolymph	1.16104799
57	MP0002067_abnormal_sensory_capabilities	1.15692568
58	MP0001919_abnormal_reproductive_system	1.14474179
59	MP0002229_neurodegeneration	1.13902355
60	MP0004133_heterotaxia	1.13661531
61	MP0003123_paternal_imprinting	1.13493773
62	MP0002733_abnormal_thermal_nociception	1.12740422
63	MP0001905_abnormal_dopamine_level	1.12581615
64	MP0002557_abnormal_social/conspecific_i	1.12287990
65	MP0003633_abnormal_nervous_system	1.11723324
66	MP0005332_abnormal_amino_acid	1.10281611
67	MP0001486_abnormal_startle_reflex	1.07152757
68	MP0001485_abnormal_pinna_reflex	1.06561643
69	MP0001348_abnormal_lacrimal_gland	1.03954180
70	MP0002736_abnormal_nociception_after	1.00523136
71	MP0010386_abnormal_urinary_bladder	0.97954298
72	MP0002928_abnormal_bile_duct	0.97914239
73	MP0005448_abnormal_energy_balance	0.92595127
74	MP0000955_abnormal_spinal_cord	0.91940623
75	MP0002693_abnormal_pancreas_physiology	0.91771775
76	MP0006082_CNS_inflammation	0.91615079
77	MP0008775_abnormal_heart_ventricle	0.91315593
78	MP0008058_abnormal_DNA_repair	0.89203056
79	MP0005075_abnormal_melanosome_morpholog	0.89002107
80	MP0000538_abnormal_urinary_bladder	0.88789615
81	MP0009780_abnormal_chondrocyte_physiolo	0.88322750
82	MP0002734_abnormal_mechanical_nocicepti	0.88100422
83	MP0004215_abnormal_myocardial_fiber	0.86359992
84	MP0005410_abnormal_fertilization	0.85294689
85	MP0003786_premature_aging	0.84219104
86	MP0005646_abnormal_pituitary_gland	0.83305136
87	MP0001502_abnormal_circadian_rhythm	0.79869096
88	MP0005423_abnormal_somatic_nervous	0.79057017
89	MP0002063_abnormal_learning/memory/cond	0.78966522
90	MP0002095_abnormal_skin_pigmentation	0.78702570
91	MP0001756_abnormal_urination	0.78236619
92	MP0008004_abnormal_stomach_pH	0.78132962
93	MP0006054_spinal_hemorrhage	0.76149220
94	MP0003631_nervous_system_phenotype	0.75314938
95	MP0002210_abnormal_sex_determination	0.75267895
96	MP0000685_abnormal_immune_system	0.74543415
97	MP0001765_abnormal_ion_homeostasis	0.74432322
98	MP0003698_abnormal_male_reproductive	0.73839654
99	MP0004130_abnormal_muscle_cell	0.73324029
100	MP0001944_abnormal_pancreas_morphology	0.73118488

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	3.47734191
2	Renal cortical cysts (HP:0000803)	3.47335080
3	Type II lissencephaly (HP:0007260)	3.44896936
4	Medial flaring of the eyebrow (HP:0010747)	3.38472847
5	Type 2 muscle fiber atrophy (HP:0003554)	3.29070375
6	Gait imbalance (HP:0002141)	3.11950183
7	Increased hepatocellular lipid droplets (HP:0006565)	3.11038243
8	Lipid accumulation in hepatocytes (HP:0006561)	3.10562164
9	Cerebellar dysplasia (HP:0007033)	3.05610946
10	Broad-based gait (HP:0002136)	3.04600330
11	Nephrogenic diabetes insipidus (HP:0009806)	2.92156641
12	Congenital primary aphakia (HP:0007707)	2.88538801
13	Abnormal sex determination (HP:0012244)	2.78651398
14	Sex reversal (HP:0012245)	2.78651398
15	Abnormality of the renal cortex (HP:0011035)	2.77484701
16	Congenital stationary night blindness (HP:0007642)	2.77287588
17	Mitochondrial inheritance (HP:0001427)	2.73611363
18	Hepatic necrosis (HP:0002605)	2.72982615
19	Hypomagnesemia (HP:0002917)	2.72040256
20	Myotonia (HP:0002486)	2.69181307
21	Muscle fiber atrophy (HP:0100295)	2.67031110
22	Abnormality of midbrain morphology (HP:0002418)	2.63162845
23	Molar tooth sign on MRI (HP:0002419)	2.63162845
24	Acute necrotizing encephalopathy (HP:0006965)	2.57178430
25	Nephronophthisis (HP:0000090)	2.56068841
26	Pancreatic fibrosis (HP:0100732)	2.55346926
27	Lissencephaly (HP:0001339)	2.51927339
28	Abnormality of glycolysis (HP:0004366)	2.51291657
29	Aplasia/hypoplasia of the uterus (HP:0008684)	2.50582914
30	Large for gestational age (HP:0001520)	2.49604745
31	Pancreatic cysts (HP:0001737)	2.44565334
32	Gonadotropin excess (HP:0000837)	2.42957699
33	Increased CSF lactate (HP:0002490)	2.42259563
34	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.41455218
35	Acute encephalopathy (HP:0006846)	2.40360907
36	Abolished electroretinogram (ERG) (HP:0000550)	2.34533837
37	Agitation (HP:0000713)	2.32302858
38	Progressive macrocephaly (HP:0004481)	2.32196125
39	Renal Fanconi syndrome (HP:0001994)	2.29661097
40	Generalized aminoaciduria (HP:0002909)	2.27534099
41	Hepatocellular necrosis (HP:0001404)	2.27455694
42	Abnormal pancreas size (HP:0012094)	2.27145106
43	Palpitations (HP:0001962)	2.25949463
44	Abnormality of the labia minora (HP:0012880)	2.25859171
45	Asplenia (HP:0001746)	2.24751747
46	Increased serum pyruvate (HP:0003542)	2.23124748
47	Pachygyria (HP:0001302)	2.21115057
48	Increased intramyocellular lipid droplets (HP:0012240)	2.20694908
49	Progressive cerebellar ataxia (HP:0002073)	2.18307849
50	Increased serum lactate (HP:0002151)	2.18263132
51	Abnormal mitochondria in muscle tissue (HP:0008316)	2.16518338
52	Genital tract atresia (HP:0001827)	2.15550359
53	Attenuation of retinal blood vessels (HP:0007843)	2.14949149
54	Vaginal atresia (HP:0000148)	2.12658279
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12549727
56	Glycosuria (HP:0003076)	2.12199174
57	Abnormality of urine glucose concentration (HP:0011016)	2.12199174
58	Hypothermia (HP:0002045)	2.11094945
59	Tubulointerstitial nephritis (HP:0001970)	2.08819097
60	Inability to walk (HP:0002540)	2.08115269
61	Nausea (HP:0002018)	2.06839450
62	Abnormality of magnesium homeostasis (HP:0004921)	2.06530060
63	Abnormality of the renal medulla (HP:0100957)	2.06297482
64	Cerebral edema (HP:0002181)	2.03537685
65	Methylmalonic acidemia (HP:0002912)	2.02411562
66	3-Methylglutaconic aciduria (HP:0003535)	1.99811509
67	Papilledema (HP:0001085)	1.99314028
68	Occipital encephalocele (HP:0002085)	1.99164782
69	True hermaphroditism (HP:0010459)	1.96758595
70	Urinary bladder sphincter dysfunction (HP:0002839)	1.93944888
71	Increased muscle lipid content (HP:0009058)	1.92252123
72	Chronic bronchitis (HP:0004469)	1.89891493
73	Unilateral renal agenesis (HP:0000122)	1.89710284
74	Methylmalonic aciduria (HP:0012120)	1.89428458
75	Spastic tetraplegia (HP:0002510)	1.88402710
76	Pendular nystagmus (HP:0012043)	1.86774339
77	Hypoglycemic coma (HP:0001325)	1.86416811
78	Hypoplasia of the pons (HP:0012110)	1.86128488
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.86116043
80	Hyperventilation (HP:0002883)	1.84247734
81	Abnormality of macular pigmentation (HP:0008002)	1.83733200
82	Gaze-evoked nystagmus (HP:0000640)	1.83260159
83	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.83169981
84	Tubular atrophy (HP:0000092)	1.82741511
85	Neoplasm of the adrenal cortex (HP:0100641)	1.82283651
86	Specific learning disability (HP:0001328)	1.78637759
87	Ketosis (HP:0001946)	1.77633121
88	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.77534068
89	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.76192177
90	Abnormality of methionine metabolism (HP:0010901)	1.75006008
91	Alkalosis (HP:0001948)	1.73960915
92	Oligomenorrhea (HP:0000876)	1.72793856
93	Exertional dyspnea (HP:0002875)	1.71828146
94	Ketoacidosis (HP:0001993)	1.70737366
95	Thyroiditis (HP:0100646)	1.70719588
96	Autoimmune thrombocytopenia (HP:0001973)	1.69688354
97	Poor coordination (HP:0002370)	1.68155886
98	Abnormality of the pons (HP:0007361)	1.67939332
99	Polyuria (HP:0000103)	1.67759647
100	Renal salt wasting (HP:0000127)	1.67418499

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	6.04304416
2	NUAK1	4.97000719
3	FRK	4.36440511
4	MST4	3.79283055
5	PLK4	3.36178832
6	TAOK3	2.86319186
7	TIE1	2.74941627
8	BMPR1B	2.61401486
9	MAP4K2	2.05383961
10	GRK1	2.03119851
11	TAF1	1.96780683
12	PDK2	1.89571091
13	WNK3	1.88515673
14	WNK4	1.82447479
15	TNIK	1.71353860
16	MARK1	1.63253387
17	ADRBK2	1.57604792
18	PLK2	1.56453524
19	PRKD3	1.53463819
20	PINK1	1.44328983
21	FGFR2	1.44021476
22	MAP3K4	1.41118449
23	STK3	1.39659368
24	OXSR1	1.34075093
25	BUB1	1.32707558
26	VRK1	1.25989487
27	TRPM7	1.25386720
28	NEK6	1.23963483
29	DAPK2	1.18717210
30	CSNK1G1	1.06343270
31	EIF2AK3	1.05063020
32	PIK3CG	1.02816996
33	CSNK1G3	0.99399915
34	CSNK1G2	0.96201044
35	INSRR	0.94603166
36	STK39	0.87673589
37	MAPK13	0.87608673
38	PHKG2	0.87174034
39	PHKG1	0.87174034
40	PRKCE	0.85031200
41	BCKDK	0.84134376
42	CASK	0.79848550
43	CAMKK2	0.77678791
44	ZAK	0.77246369
45	PLK3	0.76447310
46	PAK3	0.76405983
47	CSNK1A1L	0.73052274
48	VRK2	0.70424367
49	EIF2AK1	0.69604886
50	CDK19	0.67873730
51	ADRBK1	0.65160781
52	DYRK2	0.64641270
53	TLK1	0.61193142
54	TGFBR1	0.60619100
55	MAP2K6	0.55860985
56	WNK1	0.53995506
57	PIK3CA	0.53595071
58	RPS6KA4	0.53190540
59	ACVR1B	0.52299512
60	NLK	0.51401985
61	NTRK2	0.51301779
62	MAPK12	0.49730604
63	CDK3	0.47354255
64	STK38L	0.46883355
65	MINK1	0.46016139
66	PRKCG	0.45959833
67	ERBB3	0.45860742
68	MUSK	0.44861870
69	PRKG1	0.42368906
70	TXK	0.42364215
71	MAPK7	0.42338376
72	CAMK2A	0.42040240
73	SGK2	0.41749132
74	UHMK1	0.41536802
75	EPHA3	0.41344331
76	BRSK1	0.36357137
77	PRKACA	0.36000184
78	CSNK1A1	0.34887876
79	LIMK1	0.34119219
80	STK38	0.33618187
81	DYRK1A	0.33246946
82	MAP3K2	0.31762187
83	STK16	0.30129854
84	TEC	0.29069677
85	IGF1R	0.28957012
86	BRD4	0.28206303
87	SGK223	0.28031119
88	SGK494	0.28031119
89	MAP2K7	0.27219682
90	PRKCI	0.27073577
91	CSNK1D	0.25701558
92	FER	0.25566845
93	ITK	0.22633126
94	STK10	0.21670670
95	CSNK1E	0.21100932
96	BCR	0.20931142
97	PRKAA2	0.20118792
98	CSNK2A2	0.19783387
99	OBSCN	0.18951284
100	PRKCA	0.18337844

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.89959323
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.93956134
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.82834539
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.70731862
5	Butanoate metabolism_Homo sapiens_hsa00650	2.49298398
6	Asthma_Homo sapiens_hsa05310	2.39488178
7	Protein export_Homo sapiens_hsa03060	2.37941838
8	Parkinsons disease_Homo sapiens_hsa05012	2.19206612
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.09384326
10	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.05133452
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.99659004
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.97271901
13	Phototransduction_Homo sapiens_hsa04744	1.89851118
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.89614578
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.88418542
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83396066
17	Propanoate metabolism_Homo sapiens_hsa00640	1.68623547
18	Nicotine addiction_Homo sapiens_hsa05033	1.66862352
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.65434397
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56087731
21	Fatty acid degradation_Homo sapiens_hsa00071	1.51005993
22	RNA polymerase_Homo sapiens_hsa03020	1.49067759
23	Sulfur relay system_Homo sapiens_hsa04122	1.46954808
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.45587206
25	GABAergic synapse_Homo sapiens_hsa04727	1.43656825
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.42000486
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.41483549
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.41117697
29	Morphine addiction_Homo sapiens_hsa05032	1.36554574
30	RNA degradation_Homo sapiens_hsa03018	1.36282682
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.34668357
32	Taste transduction_Homo sapiens_hsa04742	1.25039685
33	Insulin secretion_Homo sapiens_hsa04911	1.21979835
34	Peroxisome_Homo sapiens_hsa04146	1.20257954
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17802953
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.17391481
37	Olfactory transduction_Homo sapiens_hsa04740	1.16985966
38	Huntingtons disease_Homo sapiens_hsa05016	1.16954554
39	Alzheimers disease_Homo sapiens_hsa05010	1.14479840
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.14056449
41	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.12634431
42	Basal transcription factors_Homo sapiens_hsa03022	1.10878246
43	Lysine degradation_Homo sapiens_hsa00310	1.03348097
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.03096876
45	Circadian entrainment_Homo sapiens_hsa04713	0.96337623
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96327069
47	Type I diabetes mellitus_Homo sapiens_hsa04940	0.96251387
48	Vibrio cholerae infection_Homo sapiens_hsa05110	0.96068605
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94022073
50	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.91690327
51	Sulfur metabolism_Homo sapiens_hsa00920	0.89547636
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.89012242
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88825062
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.86209162
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84930536
56	Serotonergic synapse_Homo sapiens_hsa04726	0.80963776
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78912489
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77809047
59	Fatty acid elongation_Homo sapiens_hsa00062	0.77019935
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76163357
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72279184
62	One carbon pool by folate_Homo sapiens_hsa00670	0.71454092
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.67560479
64	Proteasome_Homo sapiens_hsa03050	0.67429341
65	Retinol metabolism_Homo sapiens_hsa00830	0.67167066
66	Metabolic pathways_Homo sapiens_hsa01100	0.66078747
67	Folate biosynthesis_Homo sapiens_hsa00790	0.63807328
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63319381
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.62836813
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60912662
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.60485521
72	Salivary secretion_Homo sapiens_hsa04970	0.60017181
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58318024
74	Purine metabolism_Homo sapiens_hsa00230	0.57663358
75	Caffeine metabolism_Homo sapiens_hsa00232	0.56118579
76	Regulation of autophagy_Homo sapiens_hsa04140	0.53206224
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52513988
78	Circadian rhythm_Homo sapiens_hsa04710	0.51821295
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.51467033
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.50167423
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49296532
82	Oocyte meiosis_Homo sapiens_hsa04114	0.48114441
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.47605942
84	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46637535
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45025187
86	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44854746
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43128350
88	Homologous recombination_Homo sapiens_hsa03440	0.41795133
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.40136293
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39911068
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39685359
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39561466
93	Amphetamine addiction_Homo sapiens_hsa05031	0.37650318
94	Long-term depression_Homo sapiens_hsa04730	0.37556463
95	Ribosome_Homo sapiens_hsa03010	0.36396344
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.36170512
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33959485
98	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.31422979
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.31300614
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.31245087

UBE3AP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »