UBE3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.03073800
2carnitine shuttle (GO:0006853)4.91268524
3fatty acid transmembrane transport (GO:1902001)4.49083597
4carnitine transmembrane transport (GO:1902603)4.28742239
5sarcomere organization (GO:0045214)4.22115473
6amino-acid betaine transport (GO:0015838)4.14505426
7carnitine transport (GO:0015879)4.14505426
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.05429598
9cardiac myofibril assembly (GO:0055003)4.02724244
10regulation of fatty acid beta-oxidation (GO:0031998)3.98849972
11negative regulation of cell size (GO:0045792)3.97404290
12tricarboxylic acid cycle (GO:0006099)3.93671407
13lysine metabolic process (GO:0006553)3.93157924
14lysine catabolic process (GO:0006554)3.93157924
152-oxoglutarate metabolic process (GO:0006103)3.88693952
16regulation of fatty acid oxidation (GO:0046320)3.77931119
17muscle filament sliding (GO:0030049)3.73366613
18actin-myosin filament sliding (GO:0033275)3.73366613
19negative regulation of potassium ion transmembrane transport (GO:1901380)3.72632715
20alpha-linolenic acid metabolic process (GO:0036109)3.67695403
21positive regulation of fatty acid beta-oxidation (GO:0032000)3.66261230
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.60954590
23myofibril assembly (GO:0030239)3.51251174
24macroautophagy (GO:0016236)3.37696524
25tricarboxylic acid metabolic process (GO:0072350)3.36305600
26regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.33628317
27cardiac muscle contraction (GO:0060048)3.30463969
28positive regulation of receptor recycling (GO:0001921)3.26850848
29aspartate family amino acid catabolic process (GO:0009068)3.22090034
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.20530813
31barbed-end actin filament capping (GO:0051016)3.19165005
32regulation of NFAT protein import into nucleus (GO:0051532)3.17351449
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.15942935
34positive regulation of fatty acid oxidation (GO:0046321)3.13339210
35fibroblast migration (GO:0010761)3.12644386
36positive regulation of histone deacetylation (GO:0031065)3.12018926
37valine metabolic process (GO:0006573)3.12014872
38regulation of skeletal muscle contraction (GO:0014819)3.10225767
39regulation of integrin-mediated signaling pathway (GO:2001044)3.10002811
40quaternary ammonium group transport (GO:0015697)3.07793011
41fatty acid beta-oxidation (GO:0006635)3.04357122
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04159723
43dicarboxylic acid biosynthetic process (GO:0043650)3.01160617
44oxaloacetate metabolic process (GO:0006107)3.00848402
45regulation of cholesterol homeostasis (GO:2000188)3.00408690
46regulation of sequestering of triglyceride (GO:0010889)2.96847340
47actomyosin structure organization (GO:0031032)2.96581754
48cytoskeletal anchoring at plasma membrane (GO:0007016)2.96077618
49low-density lipoprotein particle clearance (GO:0034383)2.92510589
50protein targeting to plasma membrane (GO:0072661)2.90944861
51actin-mediated cell contraction (GO:0070252)2.87700054
52desmosome organization (GO:0002934)2.85946909
534-hydroxyproline metabolic process (GO:0019471)2.85398863
54cell communication involved in cardiac conduction (GO:0086065)2.84987740
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84295328
56positive regulation of glycogen biosynthetic process (GO:0045725)2.82878693
57sodium ion export (GO:0071436)2.82761494
58carnitine metabolic process (GO:0009437)2.81926790
59regulation of platelet aggregation (GO:0090330)2.81388056
60adherens junction assembly (GO:0034333)2.77407131
61striated muscle contraction (GO:0006941)2.76301689
62NADH metabolic process (GO:0006734)2.75180759
63positive regulation of lipid catabolic process (GO:0050996)2.73533124
64focal adhesion assembly (GO:0048041)2.72601795
65cell-substrate adherens junction assembly (GO:0007045)2.72601795
66cell communication by electrical coupling (GO:0010644)2.72395179
67peptidyl-lysine dimethylation (GO:0018027)2.71913991
68bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70816291
69negative regulation of heart growth (GO:0061117)2.69818462
70negative regulation of cardiac muscle tissue growth (GO:0055022)2.69818462
71regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67382839
72negative regulation of fatty acid transport (GO:2000192)2.66492278
73skeletal muscle adaptation (GO:0043501)2.66335895
74glycolytic process (GO:0006096)2.65267544
75cell-substrate junction assembly (GO:0007044)2.64750066
76regulation of p38MAPK cascade (GO:1900744)2.63532295
77ventricular cardiac muscle cell action potential (GO:0086005)2.62341467
78negative regulation of protein localization to cell surface (GO:2000009)2.62100845
79amino-acid betaine metabolic process (GO:0006577)2.61387292
80cardiac muscle cell development (GO:0055013)2.61262653
81regulation of cholesterol storage (GO:0010885)2.61184751
82actin filament-based movement (GO:0030048)2.59748186
83regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.59732455
84positive regulation of glycogen metabolic process (GO:0070875)2.57200579
85fatty acid oxidation (GO:0019395)2.54901344
86intracellular lipid transport (GO:0032365)2.54879752
87fatty acid homeostasis (GO:0055089)2.54595877
88heart trabecula formation (GO:0060347)2.54446336
89acetyl-CoA metabolic process (GO:0006084)2.54006625
90sarcoplasmic reticulum calcium ion transport (GO:0070296)2.53951253
91positive regulation of triglyceride biosynthetic process (GO:0010867)2.52858614
92regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.51351366
93protein localization to endosome (GO:0036010)2.50459912
94cardiac muscle hypertrophy (GO:0003300)2.50321535
95fatty acid catabolic process (GO:0009062)2.50206915
96cellular response to epinephrine stimulus (GO:0071872)2.50084702
97glycogen catabolic process (GO:0005980)2.49704401
98stress fiber assembly (GO:0043149)2.49642065
99regulation of the force of heart contraction (GO:0002026)2.49249421
100positive regulation of myotube differentiation (GO:0010831)2.48751008
101cardiac cell development (GO:0055006)2.48674354
102lipid oxidation (GO:0034440)2.48319443
103NLS-bearing protein import into nucleus (GO:0006607)2.46523562
104epithelial cell-cell adhesion (GO:0090136)2.44206303
105glycogen metabolic process (GO:0005977)2.44105425
106hypotonic response (GO:0006971)2.43992509
107phosphatidylinositol dephosphorylation (GO:0046856)2.43935947
108positive regulation of triglyceride metabolic process (GO:0090208)2.43181325
109insulin-like growth factor receptor signaling pathway (GO:0048009)2.41691132
110heparin biosynthetic process (GO:0030210)2.41544809
111heparin metabolic process (GO:0030202)2.41544809
112endocardial cushion development (GO:0003197)2.40979141
113cellular glucan metabolic process (GO:0006073)2.40752494
114glucan metabolic process (GO:0044042)2.40752494
115positive regulation of lipid storage (GO:0010884)2.40645007
116striated muscle hypertrophy (GO:0014897)2.40104947
117regulation of tight junction assembly (GO:2000810)2.39580799
118phospholipid dephosphorylation (GO:0046839)2.39250739
119Golgi transport vesicle coating (GO:0048200)2.38829711
120COPI coating of Golgi vesicle (GO:0048205)2.38829711
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.38752882
122regulation of receptor recycling (GO:0001919)2.38404412
123glucan catabolic process (GO:0009251)2.38330102
124mannose metabolic process (GO:0006013)2.32408850
125pericardium development (GO:0060039)2.32018505
126negative regulation of stress fiber assembly (GO:0051497)2.30460223
127phospholipid scrambling (GO:0017121)2.29302620
128platelet-derived growth factor receptor signaling pathway (GO:0048008)2.28778721
129peptide catabolic process (GO:0043171)2.27202900
130negative regulation of protein localization to plasma membrane (GO:1903077)2.26726507
131response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.26668395
132response to epinephrine (GO:0071871)2.26433530
133striated muscle atrophy (GO:0014891)2.24421510
134relaxation of cardiac muscle (GO:0055119)2.24006983
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.18536711
136growth hormone receptor signaling pathway (GO:0060396)2.18081494
137actin filament capping (GO:0051693)2.16934618
138positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.15899672
139regulation of protein localization to cell surface (GO:2000008)2.14460736
140phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.14384422
141regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.12620952
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.10245127
143establishment of protein localization to plasma membrane (GO:0090002)2.10209217
144Golgi to plasma membrane protein transport (GO:0043001)2.09346603
145platelet aggregation (GO:0070527)2.09256048
146membrane raft organization (GO:0031579)2.05051198
147retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.04590352
148actin filament depolymerization (GO:0030042)2.03677722
149muscle atrophy (GO:0014889)2.02887961
150Golgi to endosome transport (GO:0006895)2.02363856
151cellular response to vitamin (GO:0071295)2.00462162
152negative regulation of actin filament depolymerization (GO:0030835)1.99659633
153retrograde transport, vesicle recycling within Golgi (GO:0000301)1.99469387
154positive regulation of macrophage differentiation (GO:0045651)1.99118657
155skin morphogenesis (GO:0043589)1.98881344
156beta-amyloid metabolic process (GO:0050435)1.98411737
157positive regulation of blood vessel endothelial cell migration (GO:0043536)1.97724801
158cellular response to growth hormone stimulus (GO:0071378)1.96117535
159cellular response to vitamin D (GO:0071305)1.95233798
160myoblast fusion (GO:0007520)1.92374655
161membrane protein ectodomain proteolysis (GO:0006509)1.91713212
162extracellular fibril organization (GO:0043206)1.91364298
163negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.90500147
164negative regulation of cell killing (GO:0031342)1.90500147
165regulation of ARF protein signal transduction (GO:0032012)1.90436064
166negative regulation of anoikis (GO:2000811)1.89886887
167platelet degranulation (GO:0002576)1.89574849
168positive regulation of muscle hypertrophy (GO:0014742)1.89427737
169positive regulation of cardiac muscle hypertrophy (GO:0010613)1.89427737
170interleukin-6-mediated signaling pathway (GO:0070102)1.89211849
171histone H3-K36 demethylation (GO:0070544)1.89109081
172vesicle coating (GO:0006901)1.88939722
173syncytium formation by plasma membrane fusion (GO:0000768)1.87685006
174negative regulation of actin filament bundle assembly (GO:0032232)1.87530427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.20001204
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.74855664
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94658738
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.84008625
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75229397
6ZNF263_19887448_ChIP-Seq_K562_Human2.73908894
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.63162834
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.52060374
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48070527
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44862694
11GATA2_21666600_ChIP-Seq_HMVEC_Human2.42210954
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.26569739
13KDM2B_26808549_Chip-Seq_DND41_Human2.22163324
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21759531
15LXR_22292898_ChIP-Seq_THP-1_Human2.21584732
16MYC_22102868_ChIP-Seq_BL_Human2.18436435
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12808918
18TCF7_22412390_ChIP-Seq_EML_Mouse2.11031196
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08462407
20CLOCK_20551151_ChIP-Seq_293T_Human2.06704096
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06158421
22TBX20_22328084_ChIP-Seq_HEART_Mouse2.02613256
23TBX20_22080862_ChIP-Seq_HEART_Mouse2.02613256
24GBX2_23144817_ChIP-Seq_PC3_Human1.99563672
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98562402
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98359204
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92318566
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.90706478
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84671555
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83110815
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80768317
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73681412
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.73452319
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73398838
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67685523
36RACK7_27058665_Chip-Seq_MCF-7_Human1.67677837
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64989401
38KDM2B_26808549_Chip-Seq_K562_Human1.64503700
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.64118550
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63853246
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61876421
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60236839
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.59125675
44AHR_22903824_ChIP-Seq_MCF-7_Human1.57475561
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55321110
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50864858
47VDR_21846776_ChIP-Seq_THP-1_Human1.49253492
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48360843
49* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46307473
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.44675283
51P68_20966046_ChIP-Seq_HELA_Human1.44458344
52ATF3_27146783_Chip-Seq_COLON_Human1.40533672
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40321374
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.37328215
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36756128
56TP53_16413492_ChIP-PET_HCT116_Human1.36104481
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35613886
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.35353968
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35313944
60GATA2_19941826_ChIP-Seq_K562_Human1.33814532
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33395454
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.31960067
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31823180
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.31455369
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.31364764
66CREB1_26743006_Chip-Seq_LNCaP_Human1.30633711
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30120726
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29735484
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28144946
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27824654
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27824654
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.27693517
73MAF_26560356_Chip-Seq_TH1_Human1.24160999
74CJUN_26792858_Chip-Seq_BT549_Human1.23945985
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23600357
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23179961
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22158996
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22137455
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22008388
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21805699
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.21631594
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.21114846
83* RUNX1_27514584_Chip-Seq_MCF-7_Human1.20822506
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20757840
85SMC4_20622854_ChIP-Seq_HELA_Human1.20395619
86* TP63_22573176_ChIP-Seq_HFKS_Human1.20323268
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20256068
88BCOR_27268052_Chip-Seq_Bcells_Human1.19712369
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18612676
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18556488
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18506078
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18437594
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15939919
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15422903
95GATA1_19941826_ChIP-Seq_K562_Human1.15276875
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14298950
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14223886
98BCL6_27268052_Chip-Seq_Bcells_Human1.13903459
99UTX_26944678_Chip-Seq_JUKART_Human1.13223599
100BRD4_25478319_ChIP-Seq_HGPS_Human1.13163216
101* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13008995
102RUNX_20019798_ChIP-Seq_JUKART_Human1.12974332
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12365591
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.12239210
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10668240
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10377809
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09628660
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08186175
109CTCF_27219007_Chip-Seq_Bcells_Human1.08130431
110NCOR1_26117541_ChIP-Seq_K562_Human1.07362960
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06760545
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06646897
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06646897
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06563761
115TP53_22127205_ChIP-Seq_IMR90_Human1.06562551
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06406348
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05400805
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04738228
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03581084
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03546203
121DROSHA_22980978_ChIP-Seq_HELA_Human1.01971822
122TRIM28_21343339_ChIP-Seq_HEK293_Human1.01517335
123* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01254706
124* GATA1_19941827_ChIP-Seq_MEL_Mouse1.00936884
125SA1_27219007_Chip-Seq_ERYTHROID_Human1.00279164
126SPI1_23127762_ChIP-Seq_K562_Human1.00151818
127* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99512077
128STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99214193
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98794663
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98460112
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98253754
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98045712
133IRF8_27001747_Chip-Seq_BMDM_Mouse0.98017559
134* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97930972
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97578142
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97479362
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97055863
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95506604
139CTCF_21964334_Chip-Seq_Bcells_Human0.95334626
140CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95283894
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94958097
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.93996541
143VDR_24787735_ChIP-Seq_THP-1_Human0.93876329
144* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93847693
145NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93643270
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93377074
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93130428
148SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92520356
149GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91962786
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91721925
151JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87897392
152TP53_18474530_ChIP-ChIP_U2OS_Human0.87604125
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86647948
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85544222
155* SMAD4_21799915_ChIP-Seq_A2780_Human0.84879961
156GATA1_22025678_ChIP-Seq_K562_Human0.84165507
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83816226
158SOX2_20726797_ChIP-Seq_SW620_Human0.83506440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.89017490
2MP0003705_abnormal_hypodermis_morpholog3.83517096
3MP0000751_myopathy3.77573067
4MP0002837_dystrophic_cardiac_calcinosis3.51843654
5MP0004130_abnormal_muscle_cell3.07757057
6MP0004084_abnormal_cardiac_muscle3.06212939
7MP0005409_darkened_coat_color2.71472486
8MP0000749_muscle_degeneration2.70897505
9MP0004087_abnormal_muscle_fiber2.61288831
10MP0004036_abnormal_muscle_relaxation2.59056535
11MP0005670_abnormal_white_adipose2.40940518
12MP0005464_abnormal_platelet_physiology2.27707431
13MP0004233_abnormal_muscle_weight2.20285884
14MP0005330_cardiomyopathy2.12461791
15MP0002269_muscular_atrophy2.11174738
16MP0005360_urolithiasis2.10914735
17MP0005666_abnormal_adipose_tissue2.06083458
18MP0010630_abnormal_cardiac_muscle1.97365841
19MP0002332_abnormal_exercise_endurance1.96368061
20MP0005451_abnormal_body_composition1.93440893
21MP0005058_abnormal_lysosome_morphology1.87106246
22MP0002106_abnormal_muscle_physiology1.85673461
23MP0000747_muscle_weakness1.84821365
24MP0005410_abnormal_fertilization1.81366476
25MP0004185_abnormal_adipocyte_glucose1.80190563
26MP0000750_abnormal_muscle_regeneration1.80107595
27MP0002139_abnormal_hepatobiliary_system1.78268910
28MP0000759_abnormal_skeletal_muscle1.78179896
29MP0004215_abnormal_myocardial_fiber1.77788066
30MP0006054_spinal_hemorrhage1.74015077
31MP0004145_abnormal_muscle_electrophysio1.71205046
32MP0005620_abnormal_muscle_contractility1.69313520
33MP0008961_abnormal_basal_metabolism1.69087288
34MP0010352_gastrointestinal_tract_polyps1.66848135
35MP0008438_abnormal_cutaneous_collagen1.66552056
36MP0009840_abnormal_foam_cell1.64470736
37MP0001544_abnormal_cardiovascular_syste1.62905594
38MP0005385_cardiovascular_system_phenoty1.62905594
39MP0010329_abnormal_lipoprotein_level1.61250147
40MP0005375_adipose_tissue_phenotype1.59751426
41MP0005085_abnormal_gallbladder_physiolo1.56474007
42MP0002972_abnormal_cardiac_muscle1.54927501
43MP0000733_abnormal_muscle_development1.52193415
44MP0008775_abnormal_heart_ventricle1.51849243
45MP0005365_abnormal_bile_salt1.51549053
46MP0003566_abnormal_cell_adhesion1.50779304
47MP0008260_abnormal_autophagy1.49225735
48MP0003300_gastrointestinal_ulcer1.46710932
49MP0005369_muscle_phenotype1.45843025
50MP0003252_abnormal_bile_duct1.44840825
51MP0005076_abnormal_cell_differentiation1.42727623
52MP0006138_congestive_heart_failure1.41782776
53MP0008004_abnormal_stomach_pH1.41632989
54MP0005275_abnormal_skin_tensile1.41518926
55MP0005623_abnormal_meninges_morphology1.38507532
56MP0003950_abnormal_plasma_membrane1.38301724
57MP0010234_abnormal_vibrissa_follicle1.33944990
58MP0003279_aneurysm1.32128504
59MP0003221_abnormal_cardiomyocyte_apopto1.32034776
60MP0004510_myositis1.32005625
61MP0005083_abnormal_biliary_tract1.31112774
62MP0001849_ear_inflammation1.23891435
63MP0004858_abnormal_nervous_system1.23356809
64MP0001879_abnormal_lymphatic_vessel1.22908078
65MP0003172_abnormal_lysosome_physiology1.19072000
66MP0003191_abnormal_cellular_cholesterol1.19036705
67MP0000003_abnormal_adipose_tissue1.16762172
68MP0003329_amyloid_beta_deposits1.16427567
69MP0002168_other_aberrant_phenotype1.15751134
70MP0003724_increased_susceptibility_to1.13495345
71MP0002127_abnormal_cardiovascular_syste1.12409880
72MP0000013_abnormal_adipose_tissue1.11555638
73MP0001958_emphysema1.11531407
74MP0003806_abnormal_nucleotide_metabolis1.11332120
75MP0002909_abnormal_adrenal_gland1.07470892
76MP0003183_abnormal_peptide_metabolism1.05854123
77MP0005319_abnormal_enzyme/_coenzyme1.03833339
78MP0003453_abnormal_keratinocyte_physiol1.02589435
79MP0002896_abnormal_bone_mineralization1.02425118
80MP0002234_abnormal_pharynx_morphology1.01468882
81MP0002118_abnormal_lipid_homeostasis1.01252401
82MP0000266_abnormal_heart_morphology1.01174811
83MP0000015_abnormal_ear_pigmentation1.00822680
84MP0000609_abnormal_liver_physiology0.99342625
85MP0005164_abnormal_response_to0.98465565
86MP0004134_abnormal_chest_morphology0.96654081
87MP0004484_altered_response_of0.96648869
88MP0010368_abnormal_lymphatic_system0.96004169
89MP0009278_abnormal_bone_marrow0.95155422
90MP0000465_gastrointestinal_hemorrhage0.93763618
91MP0002971_abnormal_brown_adipose0.92065608
92MP0003137_abnormal_impulse_conducting0.91624257
93MP0002089_abnormal_postnatal_growth/wei0.90482707
94MP0005023_abnormal_wound_healing0.89999463
95MP0006036_abnormal_mitochondrial_physio0.89667222
96MP0002128_abnormal_blood_circulation0.89336283
97MP0002060_abnormal_skin_morphology0.88846823
98MP0000920_abnormal_myelination0.88502206
99MP0001542_abnormal_bone_strength0.88413984
100MP0000249_abnormal_blood_vessel0.87760319
101MP0003828_pulmonary_edema0.86124376
102MP0005165_increased_susceptibility_to0.85226186
103MP0005584_abnormal_enzyme/coenzyme_acti0.85184729
104MP0003115_abnormal_respiratory_system0.83594465
105MP0008875_abnormal_xenobiotic_pharmacok0.82142683
106MP0003045_fibrosis0.82004616
107MP0002108_abnormal_muscle_morphology0.81374230
108MP0003567_abnormal_fetal_cardiomyocyte0.81170411
109MP0003303_peritoneal_inflammation0.79795854
110MP0004883_abnormal_blood_vessel0.78746312
111MP0005187_abnormal_penis_morphology0.78511553
112MP0004272_abnormal_basement_membrane0.77949695
113MP0004085_abnormal_heartbeat0.76367173
114MP0001661_extended_life_span0.76344634
115MP0009115_abnormal_fat_cell0.75731141
116MP0004947_skin_inflammation0.75620815
117MP0003091_abnormal_cell_migration0.74953412
118MP0009780_abnormal_chondrocyte_physiolo0.71469937
119MP0005621_abnormal_cell_physiology0.70661468
120MP0005503_abnormal_tendon_morphology0.70437257
121MP0005248_abnormal_Harderian_gland0.68761386
122MP0004197_abnormal_fetal_growth/weight/0.68694277
123MP0000681_abnormal_thyroid_gland0.68641218
124MP0005332_abnormal_amino_acid0.68566444
125MP0005257_abnormal_intraocular_pressure0.67538589
126MP0003656_abnormal_erythrocyte_physiolo0.66947946
127MP0009672_abnormal_birth_weight0.66734312
128MP0008874_decreased_physiological_sensi0.66693639
129MP0005334_abnormal_fat_pad0.66567505
130MP0002925_abnormal_cardiovascular_devel0.66484880
131MP0001915_intracranial_hemorrhage0.66328860
132MP0002877_abnormal_melanocyte_morpholog0.66048390
133MP0001666_abnormal_nutrient_absorption0.64672373
134MP0005397_hematopoietic_system_phenotyp0.64663325
135MP0001545_abnormal_hematopoietic_system0.64663325
136MP0000767_abnormal_smooth_muscle0.64510421
137MP0000598_abnormal_liver_morphology0.64086097
138MP0002998_abnormal_bone_remodeling0.63951287
139MP0008770_decreased_survivor_rate0.62747530
140MP0002970_abnormal_white_adipose0.62397757
141MP0000537_abnormal_urethra_morphology0.61874992

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.78472569
2Exercise-induced muscle cramps (HP:0003710)4.59944271
3Myoglobinuria (HP:0002913)4.22704022
4Hyporeflexia of lower limbs (HP:0002600)4.22087147
5Sudden death (HP:0001699)3.97703374
6Increased connective tissue (HP:0009025)3.95941069
7Difficulty running (HP:0009046)3.86329455
8Muscle fiber splitting (HP:0003555)3.45061441
9Type 1 muscle fiber predominance (HP:0003803)3.44694408
10Calf muscle hypertrophy (HP:0008981)3.35104126
11Difficulty climbing stairs (HP:0003551)3.34785947
12Rhabdomyolysis (HP:0003201)3.34753231
13Asymmetric septal hypertrophy (HP:0001670)3.30630108
14Ventricular tachycardia (HP:0004756)3.29419569
15Bundle branch block (HP:0011710)3.26698298
16Right ventricular cardiomyopathy (HP:0011663)3.13953074
17Distal lower limb muscle weakness (HP:0009053)3.11042104
18Abnormality of the left ventricular outflow tract (HP:0011103)3.00514253
19Subaortic stenosis (HP:0001682)3.00514253
20Muscle hypertrophy of the lower extremities (HP:0008968)3.00398361
21Menorrhagia (HP:0000132)2.96661935
22Abnormality of the calf musculature (HP:0001430)2.92766293
23Increased variability in muscle fiber diameter (HP:0003557)2.86852054
24EMG: myopathic abnormalities (HP:0003458)2.79481193
25Prolonged bleeding time (HP:0003010)2.77862953
26Lymphangioma (HP:0100764)2.77066756
27Abnormality of skeletal muscle fiber size (HP:0012084)2.73256190
28Distal upper limb amyotrophy (HP:0007149)2.70774989
29Upper limb amyotrophy (HP:0009129)2.70774989
30Muscle fiber inclusion bodies (HP:0100299)2.70019358
31Broad metatarsal (HP:0001783)2.68061876
32Dysmetric saccades (HP:0000641)2.64217437
33Cerebral aneurysm (HP:0004944)2.63577765
34Lipoatrophy (HP:0100578)2.63109325
35Obstructive sleep apnea (HP:0002870)2.61370549
36Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.61227795
37Absent frontal sinuses (HP:0002688)2.59795346
38Protrusio acetabuli (HP:0003179)2.55844373
39Hyperacusis (HP:0010780)2.53924411
40Atrioventricular block (HP:0001678)2.50002771
41Premature rupture of membranes (HP:0001788)2.48695591
42Increased mean platelet volume (HP:0011877)2.47982189
43Aortic dissection (HP:0002647)2.46693061
44Abnormality of the lower motor neuron (HP:0002366)2.44512955
45Atrial fibrillation (HP:0005110)2.44068717
46Hand muscle atrophy (HP:0009130)2.43187752
47Deep venous thrombosis (HP:0002625)2.42314464
48Myotonia (HP:0002486)2.41473179
49Heart block (HP:0012722)2.39601210
50Cervical subluxation (HP:0003308)2.39257837
51Ulnar deviation of the wrist (HP:0003049)2.38921665
52Gingival bleeding (HP:0000225)2.35081974
53Primary atrial arrhythmia (HP:0001692)2.34807022
54Limb-girdle muscle atrophy (HP:0003797)2.34093975
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.33805387
56Abnormal platelet volume (HP:0011876)2.33717440
57Muscle stiffness (HP:0003552)2.33168326
58Abnormal atrioventricular conduction (HP:0005150)2.32618280
59Frequent falls (HP:0002359)2.30298219
60Distal arthrogryposis (HP:0005684)2.29000674
61Ventricular fibrillation (HP:0001663)2.27231967
62EMG: neuropathic changes (HP:0003445)2.26528361
63Supraventricular arrhythmia (HP:0005115)2.24636707
64Supraventricular tachycardia (HP:0004755)2.23484238
65Vascular tortuosity (HP:0004948)2.23193692
66Arterial tortuosity (HP:0005116)2.20429107
67Mildly elevated creatine phosphokinase (HP:0008180)2.18765029
68Ketosis (HP:0001946)2.18382575
69Ventricular arrhythmia (HP:0004308)2.16273799
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14285698
71Osteolytic defects of the hand bones (HP:0009699)2.13480377
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.13480377
73Hypoalphalipoproteinemia (HP:0003233)2.13288825
74Mitral stenosis (HP:0001718)2.12261708
75Palpitations (HP:0001962)2.11625943
76Epistaxis (HP:0000421)2.10621386
77Overgrowth (HP:0001548)2.09614181
78Spondylolisthesis (HP:0003302)2.09102412
79Round ear (HP:0100830)2.06893264
80Abnormality of the Achilles tendon (HP:0005109)2.06879859
81Ankle contracture (HP:0006466)2.06858828
82Dilated cardiomyopathy (HP:0001644)2.05000510
83Shallow orbits (HP:0000586)2.04123602
84Broad face (HP:0000283)2.03592058
85Flat acetabular roof (HP:0003180)2.03566317
86Aneurysm (HP:0002617)2.02318375
87Xanthomatosis (HP:0000991)2.02198909
88Achilles tendon contracture (HP:0001771)2.00684075
89Hypoplasia of the iris (HP:0007676)1.98787493
90Myopathic facies (HP:0002058)1.98710235
91Cholelithiasis (HP:0001081)1.96966231
92Mucopolysacchariduria (HP:0008155)1.95283221
93Urinary glycosaminoglycan excretion (HP:0003541)1.95283221
94Hyperammonemia (HP:0001987)1.95227614
95Nemaline bodies (HP:0003798)1.95073379
96Neck muscle weakness (HP:0000467)1.92153990
97Polycythemia (HP:0001901)1.91676807
98Ketoacidosis (HP:0001993)1.91301179
99Dilatation of the ascending aorta (HP:0005111)1.89214561
100Aortic aneurysm (HP:0004942)1.88438731
101Hamartoma of the eye (HP:0010568)1.87736401
102Striae distensae (HP:0001065)1.86834212
103Facial diplegia (HP:0001349)1.85091705
104Dysostosis multiplex (HP:0000943)1.84676830
105Mitral valve prolapse (HP:0001634)1.84567825
106Abnormality of the nasal mucosa (HP:0000433)1.84408354
107Scapular winging (HP:0003691)1.83692147
108Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81554577
109Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81554577
110Abnormality of polysaccharide metabolism (HP:0011012)1.81554577
111Syncope (HP:0001279)1.81375085
112Spinal rigidity (HP:0003306)1.78497363
113Reticulocytosis (HP:0001923)1.78456724
114Short nail (HP:0001799)1.78039751
115Abnormality of fatty-acid metabolism (HP:0004359)1.77716909
116Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77240798
117Atrophic scars (HP:0001075)1.76628059
118Peritonitis (HP:0002586)1.75734140
119Truncal obesity (HP:0001956)1.74465125
120Abnormal gallbladder physiology (HP:0012438)1.74120021
121Cholecystitis (HP:0001082)1.74120021
122Nasal polyposis (HP:0100582)1.73920276
123Hypercortisolism (HP:0001578)1.73666152
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73583264
125Elfin facies (HP:0004428)1.73447380
126Enlarged penis (HP:0000040)1.72115857
127Lower limb amyotrophy (HP:0007210)1.72016250
128Distal lower limb amyotrophy (HP:0008944)1.71512782
129Abnormality of the 4th metacarpal (HP:0010012)1.70300211
130Conjunctival hamartoma (HP:0100780)1.69622576
131Renovascular hypertension (HP:0100817)1.68595366
132Resting tremor (HP:0002322)1.68295749
133Papillary thyroid carcinoma (HP:0002895)1.68224600
134Rectal prolapse (HP:0002035)1.67965275
135Insomnia (HP:0100785)1.67913316
136Generalized muscle weakness (HP:0003324)1.66906237
137Rapidly progressive (HP:0003678)1.65381172
138Germ cell neoplasia (HP:0100728)1.64318147
139Neonatal death (HP:0003811)1.64270517
140Hypoglycemic coma (HP:0001325)1.63960215
141Abnormal gallbladder morphology (HP:0012437)1.63168391
142Bruising susceptibility (HP:0000978)1.60713551
143Macroorchidism (HP:0000053)1.60637695
144Skin nodule (HP:0200036)1.60588655
145Difficulty walking (HP:0002355)1.60011160
146Persistence of primary teeth (HP:0006335)1.59338890
147Purpura (HP:0000979)1.58431356
148Neoplasm of the heart (HP:0100544)1.57743479
149Long clavicles (HP:0000890)1.57580477
150Abnormality of the frontal sinuses (HP:0002687)1.57402827
151Infantile muscular hypotonia (HP:0008947)1.56911439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.28834344
2PKN24.14990017
3TTN3.69840573
4PDK42.73786908
5PDK32.73786908
6PRKD32.44907482
7EEF2K2.44835240
8MAP3K102.41891904
9ICK2.29210103
10RIPK12.23833564
11ERN12.20636019
12LMTK22.15892518
13NEK12.13055662
14TESK11.87919491
15ZAP701.80330950
16FRK1.77514673
17BCKDK1.74120673
18PDGFRA1.71768692
19PHKG11.71143050
20PHKG21.71143050
21PTK61.68881263
22BRD41.59368768
23SIK11.54533230
24GRK61.51627739
25AKT31.50879592
26OBSCN1.49687874
27MAP2K31.45598166
28FGFR41.44080889
29PDK21.42173192
30TAOK11.41154857
31DMPK1.40006086
32EPHA21.35215903
33MAP3K71.33937357
34SIK31.31447191
35PRKD21.28914067
36PRPF4B1.27712289
37MET1.26355251
38MAP3K61.25541704
39STK381.17684758
40CDK121.13810220
41LRRK21.11030891
42SGK21.06586305
43PIK3CG1.05880351
44MARK21.05008445
45CAMK1D1.02081228
46KSR20.99755356
47MTOR0.99675527
48SIK20.99574163
49GRK50.96265014
50RET0.95531724
51DAPK20.91307273
52PTK2B0.90739811
53CAMK1G0.90186054
54BMX0.89601492
55LATS20.89192731
56TYRO30.88999824
57CAMKK10.87158085
58FGFR30.86598800
59MAP3K20.85740361
60KSR10.84817410
61LATS10.84621499
62FLT30.84243470
63MAPKAPK30.83900010
64TYK20.79674415
65PAK60.79140803
66SCYL20.78395295
67RIPK40.77027319
68LIMK10.75739362
69YES10.72524177
70HCK0.72372980
71MAP4K10.72127990
72ILK0.72032497
73EPHB10.71614849
74EPHA30.70553086
75PDK10.70463537
76PAK40.70359793
77PRKCH0.68589996
78MAP3K30.66930120
79DYRK1B0.64713707
80PDGFRB0.64532412
81MAP3K110.62901342
82EIF2AK10.62855247
83SGK4940.62168005
84SGK2230.62168005
85PRKAA10.61434916
86CDK60.60582917
87TRPM70.60145663
88DDR20.59936874
89BLK0.59205289
90NEK90.59073715
91ALK0.58985847
92PINK10.58784664
93RAF10.58511118
94ROCK20.58130248
95NEK20.57043729
96PTK20.56804907
97FGFR20.56363805
98PDPK10.55435197
99CSK0.55297790
100MAP2K40.54956421
101NTRK30.54633780
102FGFR10.54407607
103HIPK20.53744321
104PRKD10.53047610
105MAPK110.52218813
106SGK30.51152394
107WNK10.51126817
108TNK20.50632960
109RPS6KA20.49697067
110CSF1R0.49542857
111EPHB20.48636995
112CAMK2G0.48201605
113TGFBR20.48007665
114ROCK10.47546942
115JAK10.47546846
116MAP3K50.46221301
117JAK20.46008510
118PAK20.45391516
119MAPK120.44712584
120FYN0.43550078
121CDK40.42996458
122MAPK70.42669801
123TGFBR10.42174896
124STK240.42170916
125RPS6KA10.41989177
126CDC42BPA0.41387875
127CAMK2B0.41211236
128MAP2K60.40374860
129PAK30.40157755
130TBK10.39861396
131MAP3K90.38245848
132MAP2K10.36780796
133DAPK30.36580750
134CAMK40.36133555
135NTRK10.35905515
136STK30.35582491
137PRKAA20.35458983
138FER0.35408576
139MAP3K10.35371365
140MYLK0.34710235
141TAOK20.33898845

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.54173230
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.31574245
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.16663441
4Nitrogen metabolism_Homo sapiens_hsa009102.56695064
5Fatty acid degradation_Homo sapiens_hsa000712.55460849
6Propanoate metabolism_Homo sapiens_hsa006402.20059204
7Carbon metabolism_Homo sapiens_hsa012001.96799725
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.86148386
9PPAR signaling pathway_Homo sapiens_hsa033201.84943320
10Fatty acid metabolism_Homo sapiens_hsa012121.83909540
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72517661
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.69909484
13Arginine biosynthesis_Homo sapiens_hsa002201.67501011
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65294874
15Pyruvate metabolism_Homo sapiens_hsa006201.65258215
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62785162
17Dilated cardiomyopathy_Homo sapiens_hsa054141.60760964
18Caffeine metabolism_Homo sapiens_hsa002321.59865514
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55782477
20Insulin resistance_Homo sapiens_hsa049311.55618309
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.54799007
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53065967
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.46557540
24Biosynthesis of amino acids_Homo sapiens_hsa012301.39656317
25Glucagon signaling pathway_Homo sapiens_hsa049221.38954517
26Inositol phosphate metabolism_Homo sapiens_hsa005621.34610382
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.34435401
28Fatty acid biosynthesis_Homo sapiens_hsa000611.33026853
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.30839414
30Circadian rhythm_Homo sapiens_hsa047101.30578805
31Insulin signaling pathway_Homo sapiens_hsa049101.29067218
32Lysine degradation_Homo sapiens_hsa003101.24963133
33Bile secretion_Homo sapiens_hsa049761.23580637
34Phospholipase D signaling pathway_Homo sapiens_hsa040721.21489874
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20931328
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19870555
37Tryptophan metabolism_Homo sapiens_hsa003801.17236191
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16961627
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15279151
40AMPK signaling pathway_Homo sapiens_hsa041521.14750566
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11403896
42Choline metabolism in cancer_Homo sapiens_hsa052311.09212568
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08936171
44Starch and sucrose metabolism_Homo sapiens_hsa005001.08509715
45Long-term potentiation_Homo sapiens_hsa047201.06704504
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.05957237
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03459276
48Other glycan degradation_Homo sapiens_hsa005111.02680612
49mTOR signaling pathway_Homo sapiens_hsa041501.00726623
50GnRH signaling pathway_Homo sapiens_hsa049120.97201476
51Viral myocarditis_Homo sapiens_hsa054160.96577801
52Chronic myeloid leukemia_Homo sapiens_hsa052200.93469464
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93266258
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91952168
55Type II diabetes mellitus_Homo sapiens_hsa049300.90500656
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90323157
57Focal adhesion_Homo sapiens_hsa045100.90285462
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89743941
59Renal cell carcinoma_Homo sapiens_hsa052110.88270325
60VEGF signaling pathway_Homo sapiens_hsa043700.87203542
61Fat digestion and absorption_Homo sapiens_hsa049750.86984772
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86571034
63Cardiac muscle contraction_Homo sapiens_hsa042600.86381246
64Butanoate metabolism_Homo sapiens_hsa006500.84556019
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84409734
66Long-term depression_Homo sapiens_hsa047300.83809088
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.80609609
68Prostate cancer_Homo sapiens_hsa052150.80481426
69Glycerolipid metabolism_Homo sapiens_hsa005610.80014067
70Lysosome_Homo sapiens_hsa041420.79485175
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78563135
72Proteoglycans in cancer_Homo sapiens_hsa052050.77795687
73Selenocompound metabolism_Homo sapiens_hsa004500.76214454
74Melanoma_Homo sapiens_hsa052180.76127014
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76045839
76Glioma_Homo sapiens_hsa052140.74928540
77ErbB signaling pathway_Homo sapiens_hsa040120.74874667
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74391089
79cAMP signaling pathway_Homo sapiens_hsa040240.73560775
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73465673
81Osteoclast differentiation_Homo sapiens_hsa043800.72917134
82HIF-1 signaling pathway_Homo sapiens_hsa040660.71293670
83Rap1 signaling pathway_Homo sapiens_hsa040150.71217711
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.71208620
85Pentose phosphate pathway_Homo sapiens_hsa000300.71019663
86FoxO signaling pathway_Homo sapiens_hsa040680.69137102
87Galactose metabolism_Homo sapiens_hsa000520.68557381
88Calcium signaling pathway_Homo sapiens_hsa040200.68423727
89Ovarian steroidogenesis_Homo sapiens_hsa049130.67669462
90Gap junction_Homo sapiens_hsa045400.66926300
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66482957
92beta-Alanine metabolism_Homo sapiens_hsa004100.65403516
93Non-small cell lung cancer_Homo sapiens_hsa052230.65157854
94Thyroid cancer_Homo sapiens_hsa052160.64583892
95Adherens junction_Homo sapiens_hsa045200.64133012
96Hepatitis C_Homo sapiens_hsa051600.63752582
97Endometrial cancer_Homo sapiens_hsa052130.63573575
98Fructose and mannose metabolism_Homo sapiens_hsa000510.63150922
99Shigellosis_Homo sapiens_hsa051310.62331797
100Acute myeloid leukemia_Homo sapiens_hsa052210.61504650
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60824511
102Amoebiasis_Homo sapiens_hsa051460.57874593
103TNF signaling pathway_Homo sapiens_hsa046680.56612866
104Oxytocin signaling pathway_Homo sapiens_hsa049210.56481944
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55588163
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55462337
107T cell receptor signaling pathway_Homo sapiens_hsa046600.55190840
108Estrogen signaling pathway_Homo sapiens_hsa049150.55161891
109Insulin secretion_Homo sapiens_hsa049110.55110138
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54904030
111Complement and coagulation cascades_Homo sapiens_hsa046100.54636070
112Cholinergic synapse_Homo sapiens_hsa047250.54182040
113Dorso-ventral axis formation_Homo sapiens_hsa043200.54132362
114MicroRNAs in cancer_Homo sapiens_hsa052060.53722490
115ABC transporters_Homo sapiens_hsa020100.53623249
116Peroxisome_Homo sapiens_hsa041460.52997531
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.51817643
118Hepatitis B_Homo sapiens_hsa051610.51264479
119MAPK signaling pathway_Homo sapiens_hsa040100.50869224
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.50574751
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.50289409
122Histidine metabolism_Homo sapiens_hsa003400.49481504
123Amphetamine addiction_Homo sapiens_hsa050310.49228139
124Gastric acid secretion_Homo sapiens_hsa049710.47933183
125Tight junction_Homo sapiens_hsa045300.47828235
126Platelet activation_Homo sapiens_hsa046110.46845816
127Small cell lung cancer_Homo sapiens_hsa052220.46016537
128Bladder cancer_Homo sapiens_hsa052190.45978090
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.45621489
130ECM-receptor interaction_Homo sapiens_hsa045120.44691646
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42352484
132Toxoplasmosis_Homo sapiens_hsa051450.42139324
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41848708
134Renin secretion_Homo sapiens_hsa049240.39869596
135Prolactin signaling pathway_Homo sapiens_hsa049170.39102810
136B cell receptor signaling pathway_Homo sapiens_hsa046620.37941867
137Notch signaling pathway_Homo sapiens_hsa043300.34185834
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33632154
139Phenylalanine metabolism_Homo sapiens_hsa003600.31489466
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31436627
141Protein digestion and absorption_Homo sapiens_hsa049740.30618479
142Endocytosis_Homo sapiens_hsa041440.29468391
143Pancreatic cancer_Homo sapiens_hsa052120.29237624

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