UBE3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.00401788
2protein localization to endosome (GO:0036010)4.30904813
3pore complex assembly (GO:0046931)4.30798880
4cell-substrate junction assembly (GO:0007044)4.25531516
5desmosome organization (GO:0002934)3.97257127
6cell-substrate adherens junction assembly (GO:0007045)3.85240743
7focal adhesion assembly (GO:0048041)3.85240743
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.83075286
9layer formation in cerebral cortex (GO:0021819)3.74018362
10cell adhesion mediated by integrin (GO:0033627)3.72653391
11mitotic chromosome condensation (GO:0007076)3.68942193
12Golgi transport vesicle coating (GO:0048200)3.68034334
13COPI coating of Golgi vesicle (GO:0048205)3.68034334
14DNA unwinding involved in DNA replication (GO:0006268)3.62715338
15regulation of glucose import in response to insulin stimulus (GO:2001273)3.52598521
16cellular protein complex localization (GO:0034629)3.52190884
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39200196
18establishment of nucleus localization (GO:0040023)3.35135084
19skin morphogenesis (GO:0043589)3.29990471
20negative regulation of fatty acid transport (GO:2000192)3.29499516
21protein localization to microtubule (GO:0035372)3.29387318
22nuclear pore complex assembly (GO:0051292)3.16688884
23peptidyl-lysine dimethylation (GO:0018027)3.11554507
24plasma membrane repair (GO:0001778)3.09997305
25mitotic sister chromatid cohesion (GO:0007064)3.09579624
26pre-miRNA processing (GO:0031054)3.08220348
27hypotonic response (GO:0006971)3.06037480
28proline transport (GO:0015824)3.04245795
29activation of Rac GTPase activity (GO:0032863)3.02332670
30regulation of early endosome to late endosome transport (GO:2000641)3.00699474
31nuclear pore organization (GO:0006999)3.00444618
32regulation of nucleobase-containing compound transport (GO:0032239)2.99244613
33epithelial cell-cell adhesion (GO:0090136)2.98022662
34negative regulation of DNA repair (GO:0045738)2.97499570
35locomotory exploration behavior (GO:0035641)2.95308259
36insulin-like growth factor receptor signaling pathway (GO:0048009)2.94981938
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.94968045
38establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.94193414
39mitochondrion transport along microtubule (GO:0047497)2.94193414
40synaptic vesicle maturation (GO:0016188)2.92892673
41positive regulation of dendritic spine morphogenesis (GO:0061003)2.92628504
42regulation of histone H3-K27 methylation (GO:0061085)2.85462036
43protein complex localization (GO:0031503)2.84191149
44iron ion import (GO:0097286)2.83736668
45embryonic process involved in female pregnancy (GO:0060136)2.83691511
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.83255102
47inner ear receptor cell development (GO:0060119)2.83077971
48basement membrane organization (GO:0071711)2.81219520
49negative regulation of organelle assembly (GO:1902116)2.80765059
50proline biosynthetic process (GO:0006561)2.79570951
51cell communication by electrical coupling (GO:0010644)2.79416154
52organelle transport along microtubule (GO:0072384)2.78667076
53activation of protein kinase A activity (GO:0034199)2.77919553
54vesicle transport along microtubule (GO:0047496)2.76505824
55histone H3-K9 demethylation (GO:0033169)2.75105583
56establishment of protein localization to Golgi (GO:0072600)2.73615190
57regulation of protein polyubiquitination (GO:1902914)2.73370738
58mammary gland epithelial cell proliferation (GO:0033598)2.73105795
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71371206
60stress granule assembly (GO:0034063)2.71195346
61protein export from nucleus (GO:0006611)2.70790789
62glutamate secretion (GO:0014047)2.68009845
63NLS-bearing protein import into nucleus (GO:0006607)2.65691077
64regulation of mammary gland epithelial cell proliferation (GO:0033599)2.65452502
65positive regulation of blood vessel endothelial cell migration (GO:0043536)2.65258936
66synaptic vesicle docking involved in exocytosis (GO:0016081)2.64545294
67endothelial cell morphogenesis (GO:0001886)2.64326837
68dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63432865
69bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63335237
70cerebellar Purkinje cell layer development (GO:0021680)2.62732755
71vesicle coating (GO:0006901)2.62622617
72dendrite morphogenesis (GO:0048813)2.60732451
73regulation of mitotic spindle organization (GO:0060236)2.60511889
74endodermal cell differentiation (GO:0035987)2.59758008
75cell migration in hindbrain (GO:0021535)2.58847657
76protein retention in ER lumen (GO:0006621)2.55367037
77protein targeting to Golgi (GO:0000042)2.55076878
78endoplasmic reticulum organization (GO:0007029)2.53562482
79axon extension (GO:0048675)2.52658914
80regulation of synaptic vesicle exocytosis (GO:2000300)2.50981987
81dendritic spine morphogenesis (GO:0060997)2.50892157
82positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.50794203
83pyrimidine nucleobase catabolic process (GO:0006208)2.50740406
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.50335918
85ER-nucleus signaling pathway (GO:0006984)2.50267275
86protein hydroxylation (GO:0018126)2.49784457
87planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49054161
88endoplasmic reticulum unfolded protein response (GO:0030968)2.48892355
89regulation of translational fidelity (GO:0006450)2.48662574
90mesodermal cell differentiation (GO:0048333)2.47121237
91regulation of glucocorticoid metabolic process (GO:0031943)2.46107610
92maternal placenta development (GO:0001893)2.45044109
93spliceosomal tri-snRNP complex assembly (GO:0000244)2.43989504
94paraxial mesoderm development (GO:0048339)2.43440095
95regulation of clathrin-mediated endocytosis (GO:2000369)2.42916057
96regulation of hippo signaling (GO:0035330)2.42268375
97branching involved in mammary gland duct morphogenesis (GO:0060444)2.41907766
98dicarboxylic acid biosynthetic process (GO:0043650)2.41646133
99cytoplasmic mRNA processing body assembly (GO:0033962)2.40712289
100regulation of protein export from nucleus (GO:0046825)2.39868316
101cell communication involved in cardiac conduction (GO:0086065)2.39789216
102macroautophagy (GO:0016236)2.39569142
103* protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.36903762
104alanine transport (GO:0032328)2.35831740
105membrane protein ectodomain proteolysis (GO:0006509)2.35571958
106regulation of transforming growth factor beta1 production (GO:0032908)2.34967740
107negative regulation of protein localization to plasma membrane (GO:1903077)2.34833499
108insulin secretion (GO:0030073)2.34508104
109peptidyl-threonine modification (GO:0018210)2.34087149
110regulation of glutamate receptor signaling pathway (GO:1900449)2.33729622
111positive regulation of keratinocyte differentiation (GO:0045618)2.33393931
112fatty acid homeostasis (GO:0055089)2.33357447
113vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.32861494
114membrane disassembly (GO:0030397)2.32412941
115nuclear envelope disassembly (GO:0051081)2.32412941
116embryonic eye morphogenesis (GO:0048048)2.32346124
117activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31992355
118mitotic nuclear envelope disassembly (GO:0007077)2.31943467
119RNA stabilization (GO:0043489)2.31724714
120mRNA stabilization (GO:0048255)2.31724714
121innervation (GO:0060384)2.31704718
122corticosteroid receptor signaling pathway (GO:0031958)2.31374836
123regulation of translational termination (GO:0006449)2.30732415
124gap junction assembly (GO:0016264)2.30651494
125hippo signaling (GO:0035329)2.30307309
126DNA duplex unwinding (GO:0032508)2.30172058
127regulation of transforming growth factor beta2 production (GO:0032909)2.30028661
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.29558122
129peptidyl-proline hydroxylation (GO:0019511)2.29092519
130cellular response to unfolded protein (GO:0034620)2.28974141
131positive regulation of synapse maturation (GO:0090129)2.28517277
132positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.28291016
133gastrulation with mouth forming second (GO:0001702)2.27578173
134cellular response to epidermal growth factor stimulus (GO:0071364)2.27535032
135regulation of fatty acid beta-oxidation (GO:0031998)2.27351057
136nerve growth factor signaling pathway (GO:0038180)2.27143408
137positive regulation of glycogen biosynthetic process (GO:0045725)2.27110587
138body morphogenesis (GO:0010171)2.26699988
139pinocytosis (GO:0006907)2.26566074
140neurotransmitter secretion (GO:0007269)2.26283453
141membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.26210671
142nucleobase-containing small molecule interconversion (GO:0015949)2.26132106
143folic acid-containing compound biosynthetic process (GO:0009396)2.25957365
144nuclear envelope organization (GO:0006998)2.25864279
145regulation of dendritic spine morphogenesis (GO:0061001)2.25801410
146nucleus localization (GO:0051647)2.23753496
147regulation of nuclease activity (GO:0032069)2.23648957
148detection of calcium ion (GO:0005513)2.23626348
149ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.20966565
150wound healing, spreading of epidermal cells (GO:0035313)2.20878406
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20427024
152regulation of cAMP-dependent protein kinase activity (GO:2000479)2.20126697
153glucocorticoid receptor signaling pathway (GO:0042921)2.18782092
1544-hydroxyproline metabolic process (GO:0019471)2.18774857
155negative regulation of anoikis (GO:2000811)2.18695692
156glial cell proliferation (GO:0014009)2.18196233
157suckling behavior (GO:0001967)2.17598291
158positive regulation of nuclease activity (GO:0032075)2.16903794
159COPII vesicle coating (GO:0048208)2.16711522
160neuron projection extension (GO:1990138)2.16387413
161regulation of RNA export from nucleus (GO:0046831)2.15472063
162regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.15102894
163synaptic vesicle exocytosis (GO:0016079)2.14998554
164positive regulation of fatty acid beta-oxidation (GO:0032000)2.14821751
165adherens junction assembly (GO:0034333)2.14504070
166regulation of NFAT protein import into nucleus (GO:0051532)2.14472905
167retrograde transport, vesicle recycling within Golgi (GO:0000301)2.13977120
168negative regulation of cell size (GO:0045792)2.13873708
169regulation of synaptic vesicle transport (GO:1902803)2.11586201
170exploration behavior (GO:0035640)2.09224398
171positive regulation of dendrite morphogenesis (GO:0050775)2.08401105
172establishment of mitochondrion localization (GO:0051654)2.07993774
173embryonic body morphogenesis (GO:0010172)2.07226604
174anterior/posterior axis specification, embryo (GO:0008595)2.06989821
175central nervous system projection neuron axonogenesis (GO:0021952)2.06612862
176vocalization behavior (GO:0071625)2.06608351
177positive regulation of glycolytic process (GO:0045821)2.06546169
178positive regulation of glycogen metabolic process (GO:0070875)2.06269052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72076211
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.14879841
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.74258516
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.12230896
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.36887757
6EZH2_22144423_ChIP-Seq_EOC_Human3.19443349
7AR_21909140_ChIP-Seq_LNCAP_Human2.73946369
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70746710
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.52176309
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.41966993
11KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.35800775
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29283697
13* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.27136751
14MYC_22102868_ChIP-Seq_BL_Human2.20659294
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08159590
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03970209
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99022795
18KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.96350691
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94647297
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.91165636
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90955441
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88324735
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88324735
24ZNF263_19887448_ChIP-Seq_K562_Human1.88232338
25RACK7_27058665_Chip-Seq_MCF-7_Human1.82162116
26* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81856924
27GBX2_23144817_ChIP-Seq_PC3_Human1.81684601
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80632756
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.79747686
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.71481740
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.70774453
32* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70243963
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69303447
34ZNF274_21170338_ChIP-Seq_K562_Hela1.69167944
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67675344
36ATF3_27146783_Chip-Seq_COLON_Human1.66686653
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66468625
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65307681
39* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64413647
40DROSHA_22980978_ChIP-Seq_HELA_Human1.63691895
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63359857
42REST_21632747_ChIP-Seq_MESCs_Mouse1.63213263
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62112116
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57235642
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55579953
46NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.54394103
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.53480266
48CHD1_26751641_Chip-Seq_LNCaP_Human1.53351024
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.52244211
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.51038786
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50710588
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.50264058
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48771383
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48239335
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48118476
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47054060
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46975940
58TCF7_22412390_ChIP-Seq_EML_Mouse1.46215856
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45357313
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45014707
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.43895967
62* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43034068
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42981423
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42154506
65CLOCK_20551151_ChIP-Seq_293T_Human1.41991359
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.41259676
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40993237
68* STAT3_23295773_ChIP-Seq_U87_Human1.40772685
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39156213
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38478714
71* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38408185
72* AR_19668381_ChIP-Seq_PC3_Human1.37091143
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35854887
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35221701
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35054638
76SMAD4_21799915_ChIP-Seq_A2780_Human1.34010000
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33171513
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32968626
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32781976
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32629508
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30200697
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29798379
83* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29375591
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28342143
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.27651845
86TFEB_21752829_ChIP-Seq_HELA_Human1.27506414
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27389451
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27112296
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27002100
90VDR_21846776_ChIP-Seq_THP-1_Human1.26167513
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25426712
92MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25360014
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.25289441
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.25137050
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24877359
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24860606
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24477467
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.23477924
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.22440039
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.22440039
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21920620
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.21859982
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21473940
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21391412
105* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20425028
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18104737
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17528192
108IGF1R_20145208_ChIP-Seq_DFB_Human1.17434276
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17165832
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16153186
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15872006
112AHR_22903824_ChIP-Seq_MCF-7_Human1.14293121
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.14094807
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12743970
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12001004
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11930930
117KDM2B_26808549_Chip-Seq_K562_Human1.11588753
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11542563
119GATA6_25053715_ChIP-Seq_YYC3_Human1.11379394
120ISL1_27105846_Chip-Seq_CPCs_Mouse1.09914236
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09865245
122STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09350957
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08953509
124AR_21572438_ChIP-Seq_LNCaP_Human1.08927198
125LXR_22158963_ChIP-Seq_LIVER_Mouse1.08562484
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08493586
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08448364
128* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08431143
129* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08304668
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07211195
131* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06885843
132TCF4_23295773_ChIP-Seq_U87_Human1.06762958
133TP53_22127205_ChIP-Seq_IMR90_Human1.06203356
134TP53_16413492_ChIP-PET_HCT116_Human1.05161620
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04819520
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04339316
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04181004
138LXR_22292898_ChIP-Seq_THP-1_Human1.04033573
139* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03792302
140NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03554613
141KDM2B_26808549_Chip-Seq_DND41_Human1.03154375
142P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03023765
143WT1_19549856_ChIP-ChIP_CCG9911_Human1.02886031
144BCAT_22108803_ChIP-Seq_LS180_Human1.01678642
145POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01269774
146GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01231818
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.98733834
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98349504
149* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98207987
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97708725
151NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97660244
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.97194857
153* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96983455
154SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96639074
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.95652376
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95449268
157EP300_21415370_ChIP-Seq_HL-1_Mouse0.94226912
158EGR1_19374776_ChIP-ChIP_THP-1_Human0.93532887
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93227274
160MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92211082
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.92140116
162* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91510798
163FOXM1_23109430_ChIP-Seq_U2OS_Human0.91348089
164SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91032330
165RXR_22158963_ChIP-Seq_LIVER_Mouse0.89747361
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87661010
167AR_25329375_ChIP-Seq_VCAP_Human0.86501393
168TCF4_18268006_ChIP-ChIP_LS174T_Human0.86314751
169ERG_21242973_ChIP-ChIP_JURKAT_Human0.85741053
170TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85178455
171NANOG_16518401_ChIP-PET_MESCs_Mouse0.84282068
172SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83851951
173SMAD4_21741376_ChIP-Seq_HESCs_Human0.83096550
174WDR5_24793694_ChIP-Seq_LNCAP_Human0.83079178
175RING1B_27294783_Chip-Seq_NPCs_Mouse0.82969077
176BRD4_25478319_ChIP-Seq_HGPS_Human0.82670561
177OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81778013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.36409663
2MP0004859_abnormal_synaptic_plasticity3.30686707
3MP0003566_abnormal_cell_adhesion2.96928289
4MP0009780_abnormal_chondrocyte_physiolo2.85515988
5MP0003705_abnormal_hypodermis_morpholog2.77537106
6MP0005451_abnormal_body_composition2.65480699
7MP0000013_abnormal_adipose_tissue2.60201215
8MP0004270_analgesia2.50973166
9MP0002877_abnormal_melanocyte_morpholog2.50929626
10MP0003283_abnormal_digestive_organ2.40638460
11MP0002837_dystrophic_cardiac_calcinosis2.40442735
12MP0004272_abnormal_basement_membrane2.33211004
13MP0010234_abnormal_vibrissa_follicle2.31991212
14MP0000569_abnormal_digit_pigmentation2.21769622
15MP0002139_abnormal_hepatobiliary_system2.14328049
16MP0002909_abnormal_adrenal_gland2.11751547
17MP0005187_abnormal_penis_morphology1.96753616
18MP0002060_abnormal_skin_morphology1.86691036
19MP0003635_abnormal_synaptic_transmissio1.86091228
20MP0005623_abnormal_meninges_morphology1.85451585
21MP0003091_abnormal_cell_migration1.84659948
22MP0005409_darkened_coat_color1.83096354
23MP0000733_abnormal_muscle_development1.76873725
24MP0003950_abnormal_plasma_membrane1.74963824
25MP0003941_abnormal_skin_development1.73485315
26MP0010352_gastrointestinal_tract_polyps1.71971376
27MP0000537_abnormal_urethra_morphology1.67423946
28MP0003123_paternal_imprinting1.64604467
29MP0003453_abnormal_keratinocyte_physiol1.64006006
30MP0002796_impaired_skin_barrier1.59597251
31MP0005275_abnormal_skin_tensile1.58383220
32MP0002063_abnormal_learning/memory/cond1.57571689
33MP0005085_abnormal_gallbladder_physiolo1.54758677
34MP0003890_abnormal_embryonic-extraembry1.54554294
35MP0004233_abnormal_muscle_weight1.54193910
36MP0008057_abnormal_DNA_replication1.51599104
37MP0005257_abnormal_intraocular_pressure1.49476888
38MP0009672_abnormal_birth_weight1.46007629
39MP0002009_preneoplasia1.43663849
40MP0005023_abnormal_wound_healing1.42072083
41MP0003119_abnormal_digestive_system1.41984590
42MP0003111_abnormal_nucleus_morphology1.40286405
43MP0008961_abnormal_basal_metabolism1.39854027
44MP0000003_abnormal_adipose_tissue1.39513667
45MP0005365_abnormal_bile_salt1.38605307
46MP0001661_extended_life_span1.38505381
47MP0001849_ear_inflammation1.35705345
48MP0004858_abnormal_nervous_system1.35541076
49MP0004130_abnormal_muscle_cell1.34465890
50MP0004957_abnormal_blastocyst_morpholog1.29112755
51MP0000751_myopathy1.28981323
52MP0003252_abnormal_bile_duct1.28225473
53MP0009703_decreased_birth_body1.26728845
54MP0001944_abnormal_pancreas_morphology1.25155605
55MP0005501_abnormal_skin_physiology1.24901097
56MP0000747_muscle_weakness1.24802046
57MP0002234_abnormal_pharynx_morphology1.23866843
58MP0001216_abnormal_epidermal_layer1.23459177
59MP0004811_abnormal_neuron_physiology1.23003984
60MP0000579_abnormal_nail_morphology1.22010949
61MP0003300_gastrointestinal_ulcer1.21913644
62MP0005076_abnormal_cell_differentiation1.21148163
63MP0002269_muscular_atrophy1.19864851
64MP0003787_abnormal_imprinting1.18395369
65MP0003191_abnormal_cellular_cholesterol1.18042784
66MP0000762_abnormal_tongue_morphology1.16662439
67MP0002734_abnormal_mechanical_nocicepti1.16236669
68MP0004145_abnormal_muscle_electrophysio1.15358213
69MP0004197_abnormal_fetal_growth/weight/1.14768524
70MP0003984_embryonic_growth_retardation1.14263971
71MP0003868_abnormal_feces_composition1.14117778
72MP0000350_abnormal_cell_proliferation1.12095714
73MP0002896_abnormal_bone_mineralization1.10944104
74MP0010307_abnormal_tumor_latency1.10654135
75MP0002078_abnormal_glucose_homeostasis1.10429804
76MP0003115_abnormal_respiratory_system1.09713257
77MP0004808_abnormal_hematopoietic_stem1.09682270
78MP0000955_abnormal_spinal_cord1.09548450
79MP0000467_abnormal_esophagus_morphology1.09435766
80MP0004084_abnormal_cardiac_muscle1.09356092
81MP0002184_abnormal_innervation1.09180970
82MP0001672_abnormal_embryogenesis/_devel1.09088311
83MP0005380_embryogenesis_phenotype1.09088311
84MP0002088_abnormal_embryonic_growth/wei1.08691459
85MP0010678_abnormal_skin_adnexa1.08324763
86MP0001299_abnormal_eye_distance/1.08172291
87MP0003942_abnormal_urinary_system1.06710297
88MP0003122_maternal_imprinting1.05423496
89MP0010630_abnormal_cardiac_muscle1.05122125
90MP0003121_genomic_imprinting1.04819194
91MP0005621_abnormal_cell_physiology1.03934157
92MP0002084_abnormal_developmental_patter1.03732489
93MP0003077_abnormal_cell_cycle1.02963856
94MP0004885_abnormal_endolymph1.02205525
95MP0002928_abnormal_bile_duct1.02137119
96MP0000749_muscle_degeneration1.02062596
97MP0001348_abnormal_lacrimal_gland1.01040360
98MP0010094_abnormal_chromosome_stability1.00654179
99MP0004185_abnormal_adipocyte_glucose0.99223799
100MP0005360_urolithiasis0.98833127
101MP0000778_abnormal_nervous_system0.98812389
102MP0010368_abnormal_lymphatic_system0.98234675
103MP0002572_abnormal_emotion/affect_behav0.98074912
104MP0003693_abnormal_embryo_hatching0.97489316
105MP0004264_abnormal_extraembryonic_tissu0.96816390
106MP0002080_prenatal_lethality0.96471899
107MP0001958_emphysema0.96301724
108MP0001915_intracranial_hemorrhage0.96055693
109MP0005375_adipose_tissue_phenotype0.95944413
110MP0000767_abnormal_smooth_muscle0.95529241
111MP0009745_abnormal_behavioral_response0.95099186
112MP0002166_altered_tumor_susceptibility0.93869795
113MP0005666_abnormal_adipose_tissue0.93064550
114MP0005330_cardiomyopathy0.92796140
115MP0006072_abnormal_retinal_apoptosis0.92665226
116MP0000627_abnormal_mammary_gland0.91704303
117MP0005248_abnormal_Harderian_gland0.91254883
118MP0002152_abnormal_brain_morphology0.91123969
119MP0003045_fibrosis0.90569315
120MP0000377_abnormal_hair_follicle0.89846592
121MP0009840_abnormal_foam_cell0.89762057
122MP0008932_abnormal_embryonic_tissue0.89441157
123MP0003861_abnormal_nervous_system0.89293488
124MP0005058_abnormal_lysosome_morphology0.88985028
125MP0008007_abnormal_cellular_replicative0.88488539
126MP0006138_congestive_heart_failure0.88175810
127MP0003279_aneurysm0.86315143
128MP0004087_abnormal_muscle_fiber0.85110144
129MP0002693_abnormal_pancreas_physiology0.85016286
130MP0004215_abnormal_myocardial_fiber0.84987715
131MP0010329_abnormal_lipoprotein_level0.84246475
132MP0001730_embryonic_growth_arrest0.84083865
133MP0003828_pulmonary_edema0.82125425
134MP0002098_abnormal_vibrissa_morphology0.81928848
135MP0003221_abnormal_cardiomyocyte_apopto0.81425060
136MP0003329_amyloid_beta_deposits0.80736896
137MP0002557_abnormal_social/conspecific_i0.80628695
138MP0001177_atelectasis0.79717065
139MP0004043_abnormal_pH_regulation0.79581719
140MP0005386_behavior/neurological_phenoty0.79367770
141MP0004924_abnormal_behavior0.79367770
142MP0002006_tumorigenesis0.79125396
143MP0008260_abnormal_autophagy0.77096579
144MP0002396_abnormal_hematopoietic_system0.76907723
145MP0003935_abnormal_craniofacial_develop0.75554479
146MP0001440_abnormal_grooming_behavior0.75291801
147MP0000858_altered_metastatic_potential0.75101036
148MP0004036_abnormal_muscle_relaxation0.74402713
149MP0002086_abnormal_extraembryonic_tissu0.74342989
150MP0005647_abnormal_sex_gland0.72794605
151MP0009053_abnormal_anal_canal0.70986124
152MP0002089_abnormal_postnatal_growth/wei0.70490060
153MP0000428_abnormal_craniofacial_morphol0.70459567
154MP0000534_abnormal_ureter_morphology0.69980704
155MP0002733_abnormal_thermal_nociception0.69806517
156MP0002882_abnormal_neuron_morphology0.69706065
157MP0002067_abnormal_sensory_capabilities0.66817488
158MP0002064_seizures0.65490778
159MP0001968_abnormal_touch/_nociception0.64917694
160MP0001697_abnormal_embryo_size0.64535866
161MP0004085_abnormal_heartbeat0.64473499
162MP0002081_perinatal_lethality0.64107625
163MP0002160_abnormal_reproductive_system0.63596487
164MP0000759_abnormal_skeletal_muscle0.63558043
165MP0002085_abnormal_embryonic_tissue0.63557787

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)3.89738322
2Premature rupture of membranes (HP:0001788)3.83713847
3Termporal pattern (HP:0011008)3.70059779
4Insidious onset (HP:0003587)3.70059779
5Protrusio acetabuli (HP:0003179)3.52272903
6Male infertility (HP:0003251)3.00692222
7Increased connective tissue (HP:0009025)2.93770585
8Osteolytic defects of the hand bones (HP:0009699)2.89986552
9Osteolytic defects of the phalanges of the hand (HP:0009771)2.89986552
10Impaired vibration sensation in the lower limbs (HP:0002166)2.85888673
11Back pain (HP:0003418)2.81796236
12Amyotrophic lateral sclerosis (HP:0007354)2.78220077
13Subacute progressive viral hepatitis (HP:0006572)2.77861786
14Hyperinsulinemic hypoglycemia (HP:0000825)2.77683290
15Distal lower limb amyotrophy (HP:0008944)2.75328655
16Atrophic scars (HP:0001075)2.67604171
17Hyperglycemia (HP:0003074)2.66980637
18Ulnar bowing (HP:0003031)2.65942992
19Type 1 muscle fiber predominance (HP:0003803)2.60283632
20Spinal rigidity (HP:0003306)2.56052959
21Shoulder girdle muscle weakness (HP:0003547)2.53840674
22Fragile skin (HP:0001030)2.52985850
23Short nail (HP:0001799)2.52482519
24Visual hallucinations (HP:0002367)2.48448730
25Hepatoblastoma (HP:0002884)2.47583939
26Vertebral compression fractures (HP:0002953)2.46697984
27Abnormality of the astrocytes (HP:0100707)2.45294447
28Astrocytoma (HP:0009592)2.45294447
29Broad face (HP:0000283)2.44605077
30Genetic anticipation (HP:0003743)2.42379438
31Achilles tendon contracture (HP:0001771)2.42366362
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.41260177
33Urinary bladder sphincter dysfunction (HP:0002839)2.40058237
34Hypoglycemic seizures (HP:0002173)2.39742462
35Flat acetabular roof (HP:0003180)2.39360021
36Asymmetry of the thorax (HP:0001555)2.36487547
37Urinary urgency (HP:0000012)2.36355979
38Macroorchidism (HP:0000053)2.35155390
39Ankle contracture (HP:0006466)2.35132975
40Exercise-induced myalgia (HP:0003738)2.32954819
41Septate vagina (HP:0001153)2.32914994
42Abnormality of the corticospinal tract (HP:0002492)2.31680273
43Abnormality of oral frenula (HP:0000190)2.31052239
44Arterial tortuosity (HP:0005116)2.30226680
45Agitation (HP:0000713)2.27096792
46Mildly elevated creatine phosphokinase (HP:0008180)2.27056064
47Papillary thyroid carcinoma (HP:0002895)2.27039537
48Right ventricular cardiomyopathy (HP:0011663)2.26352413
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.25645987
50Hypsarrhythmia (HP:0002521)2.24547901
51EEG with generalized epileptiform discharges (HP:0011198)2.23443234
52Nemaline bodies (HP:0003798)2.23022027
53Abnormality of skeletal muscle fiber size (HP:0012084)2.22524775
54Hypoglycemic coma (HP:0001325)2.21731926
55Spinal cord lesions (HP:0100561)2.21001160
56Syringomyelia (HP:0003396)2.21001160
57Muscle fiber inclusion bodies (HP:0100299)2.20973338
58Distal lower limb muscle weakness (HP:0009053)2.19958418
59Resting tremor (HP:0002322)2.19862863
60Insulin-resistant diabetes mellitus (HP:0000831)2.19796503
61Abnormality of the Achilles tendon (HP:0005109)2.18641058
62Increased variability in muscle fiber diameter (HP:0003557)2.18447352
63Advanced eruption of teeth (HP:0006288)2.18219581
64Wormian bones (HP:0002645)2.16883954
65Enlarged penis (HP:0000040)2.16714938
66Epileptiform EEG discharges (HP:0011182)2.16027724
67Vascular tortuosity (HP:0004948)2.14381587
68Shallow orbits (HP:0000586)2.10515446
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.10199557
70Abnormality of the distal phalanges of the toes (HP:0010182)2.10105012
71Dysmetric saccades (HP:0000641)2.09985944
72Bladder diverticulum (HP:0000015)2.07637071
73Ketoacidosis (HP:0001993)2.07437571
74Natal tooth (HP:0000695)2.05352064
75Elbow flexion contracture (HP:0002987)2.02002460
76Sparse lateral eyebrow (HP:0005338)2.00732937
77Selective tooth agenesis (HP:0001592)1.99066150
78Hand muscle atrophy (HP:0009130)1.98857115
79Cervical subluxation (HP:0003308)1.98020931
80Pelvic girdle muscle weakness (HP:0003749)1.95884233
81Overgrowth (HP:0001548)1.95045323
82Renovascular hypertension (HP:0100817)1.94534409
83Hamartoma of the eye (HP:0010568)1.93684106
84Progressive muscle weakness (HP:0003323)1.93518682
85Long toe (HP:0010511)1.92902947
86Focal seizures (HP:0007359)1.91370075
87Heterotopia (HP:0002282)1.91329588
88Abnormal ossification of hand bones (HP:0005921)1.90259281
89Intellectual disability, profound (HP:0002187)1.90169833
90Abnormality of carpal bone ossification (HP:0006257)1.89012663
91Ependymoma (HP:0002888)1.88541374
92Aortic dissection (HP:0002647)1.86915734
93Relative macrocephaly (HP:0004482)1.85214206
94Abnormality of the calcaneus (HP:0008364)1.84024482
95Biliary tract neoplasm (HP:0100574)1.83308101
96Mitral valve prolapse (HP:0001634)1.83030612
97Distal upper limb amyotrophy (HP:0007149)1.82731442
98Upper limb amyotrophy (HP:0009129)1.82731442
99Trismus (HP:0000211)1.80596553
100Persistence of primary teeth (HP:0006335)1.79992325
101Disproportionate tall stature (HP:0001519)1.79819943
102Vertebral arch anomaly (HP:0008438)1.79532775
103Ridged nail (HP:0001807)1.79335215
104Milia (HP:0001056)1.78892412
105Insomnia (HP:0100785)1.78693440
106Excessive salivation (HP:0003781)1.78575754
107Drooling (HP:0002307)1.78575754
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78442881
109Deviation of the thumb (HP:0009603)1.77724746
110Abnormality of the musculature of the pelvis (HP:0001469)1.75917314
111Abnormality of the hip-girdle musculature (HP:0001445)1.75917314
112Intrahepatic cholestasis (HP:0001406)1.74897516
113Aortic aneurysm (HP:0004942)1.74463650
114Patellar dislocation (HP:0002999)1.74336674
115Buphthalmos (HP:0000557)1.73563948
116Blue sclerae (HP:0000592)1.73097556
117Bowel diverticulosis (HP:0005222)1.72139891
118Glioma (HP:0009733)1.72081573
119Elfin facies (HP:0004428)1.72078992
120Global brain atrophy (HP:0002283)1.72063088
121Deep philtrum (HP:0002002)1.71806063
122Morphological abnormality of the pyramidal tract (HP:0002062)1.71488075
123Mitral stenosis (HP:0001718)1.71202040
124Impaired smooth pursuit (HP:0007772)1.70809429
125Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70214084
126Depression (HP:0000716)1.70099437
127Skin nodule (HP:0200036)1.69688282
128Focal motor seizures (HP:0011153)1.69482674
129Turricephaly (HP:0000262)1.69105393
130Dilatation of the ascending aorta (HP:0005111)1.68872805
131Scapular winging (HP:0003691)1.68439709
132Mitral regurgitation (HP:0001653)1.68132878
133Aneurysm (HP:0002617)1.67493138
134Neoplasm of the adrenal cortex (HP:0100641)1.66845144
135Overriding aorta (HP:0002623)1.66448836
136Abnormality of endocrine pancreas physiology (HP:0012093)1.66291209
137Abnormality of the pancreatic islet cells (HP:0006476)1.66291209
138Spinal cord compression (HP:0002176)1.65506257
139Rimmed vacuoles (HP:0003805)1.64856130
140Abnormality of nail color (HP:0100643)1.64039953
141Abnormality of the acetabulum (HP:0003170)1.63875525
142Pointed chin (HP:0000307)1.63729558
143Cubitus valgus (HP:0002967)1.63698750
144Impaired social interactions (HP:0000735)1.63650017
145Abnormal social behavior (HP:0012433)1.63650017
146Dislocated radial head (HP:0003083)1.63135497
147Neonatal death (HP:0003811)1.62568680
148Symptomatic seizures (HP:0011145)1.60709496
149Renal duplication (HP:0000075)1.60406953
150Reduced subcutaneous adipose tissue (HP:0003758)1.58943663
151Abnormal foot bone ossification (HP:0010675)1.58792455
152Limb-girdle muscle weakness (HP:0003325)1.58591962
153Hyperacusis (HP:0010780)1.57936578
154Generalized amyotrophy (HP:0003700)1.57807310
155Difficulty running (HP:0009046)1.57672378
156Unilateral renal agenesis (HP:0000122)1.57611897
157Impaired vibratory sensation (HP:0002495)1.57569427
158Upper motor neuron abnormality (HP:0002127)1.56017536
159Long palpebral fissure (HP:0000637)1.55998640
160Obsessive-compulsive behavior (HP:0000722)1.55982570
161Hyporeflexia of lower limbs (HP:0002600)1.55977715
162Lower limb muscle weakness (HP:0007340)1.55941201
163Fibroma (HP:0010614)1.55417066
164Lower limb amyotrophy (HP:0007210)1.55179388
165Cardiovascular calcification (HP:0011915)1.55086861
166Abnormality of the metopic suture (HP:0005556)1.53849755
167Truncal obesity (HP:0001956)1.53819907
168Fibrous tissue neoplasm (HP:0012316)1.53498275
169Megalencephaly (HP:0001355)1.53435684
170Difficulty climbing stairs (HP:0003551)1.53425045
171Cerebral aneurysm (HP:0004944)1.53087901
172Prominent metopic ridge (HP:0005487)1.52776316
173Papilledema (HP:0001085)1.51080690
174Neoplasm of the heart (HP:0100544)1.50605057
175Lymphangioma (HP:0100764)1.50099409
176Generalized tonic-clonic seizures (HP:0002069)1.49400177
177Hypopigmentation of the fundus (HP:0007894)1.48896746
178Ankyloglossia (HP:0010296)1.48281527
179Cerebral inclusion bodies (HP:0100314)1.46927769
180Inappropriate behavior (HP:0000719)1.46664794
181Atrophy/Degeneration involving motor neurons (HP:0007373)1.46487186
182Pancreatic islet-cell hyperplasia (HP:0004510)1.46320077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK32.87476693
2MARK12.84755100
3SMG12.83583909
4IRAK32.68682295
5PKN22.67852214
6MST1R2.54428785
7LATS12.52261084
8TRIB32.34620379
9MAP3K42.34092181
10PRKD32.30838522
11MAP3K92.23474384
12SCYL22.14436271
13PRPF4B2.09863326
14LATS22.06479254
15PDK41.99572905
16PDK31.99572905
17MAP3K21.93803750
18PASK1.76297059
19PNCK1.73999624
20INSRR1.68131312
21NEK11.68129800
22CDK121.65262053
23FRK1.64861663
24PDGFRA1.62770366
25KSR21.62736619
26MAP2K41.59739310
27RET1.58880147
28EEF2K1.55220754
29TRPM71.51564352
30MINK11.50361478
31ERBB31.46110353
32MAP3K131.44677373
33PAK41.42489419
34CAMKK11.42432518
35KSR11.40070885
36TTN1.36340762
37BRD41.33776076
38RIPK11.31428703
39EPHA41.29564697
40PAK61.26395401
41FGFR41.24976587
42CDC42BPA1.22739666
43FER1.22015447
44RPS6KB21.20178140
45NTRK11.19432610
46ALK1.19084370
47NEK91.17804922
48PAK31.11032824
49NME21.08676489
50PHKG11.08022211
51PHKG21.08022211
52ERN11.05584266
53PBK1.02509094
54MAP2K31.02467347
55CAMK1G0.98126124
56PTK60.97377274
57STK380.94880183
58DAPK20.93343682
59MAP3K80.92540092
60EIF2AK10.90195159
61PDK20.88643369
62MELK0.85692679
63MTOR0.83681935
64FGFR10.83101047
65NTRK20.82920000
66AKT30.82487263
67MAP3K60.82217027
68TYRO30.81363237
69MAPK110.80500557
70ARAF0.78944712
71PTK20.78395903
72CDC70.77083830
73STK30.76655739
74RPS6KA20.75028725
75PRKAA10.72416567
76CDK50.72112181
77RAF10.71828318
78MOS0.71098345
79CDK70.69391512
80STK110.69327202
81MAP3K140.69284945
82LMTK20.68968029
83PINK10.68538693
84PRKCG0.68300485
85DDR20.66776510
86EPHB10.66542593
87EPHA20.64147141
88RPS6KB10.61735840
89BRAF0.61273690
90OBSCN0.61048151
91ICK0.60984749
92TSSK60.60476971
93CDK40.59104770
94PTK2B0.58228421
95CDK80.57723018
96MAP3K30.57481677
97FGFR20.56899948
98CSNK1E0.56585640
99ILK0.55974156
100SIK10.55623146
101MAP3K70.54987593
102SGK30.54984102
103TAOK20.54329600
104RPS6KA30.54198682
105CSNK1G20.54148205
106NEK20.51841680
107MET0.51298315
108MAP2K70.50902261
109SGK10.50740501
110FGFR30.50424451
111CDK60.50079302
112MAP3K10.49655205
113CAMK1D0.49548618
114PRKD20.49304123
115PRKCH0.49068653
116MAP2K10.48888473
117CHEK20.48265919
118PAK20.48084371
119AKT20.47613397
120TAOK10.47408980
121WNK10.47056495
122PRKDC0.46411153
123CSNK1D0.46276173
124PDK10.45941050
125HIPK20.45383985
126MAP3K50.45375234
127MAPK100.45277715
128PDGFRB0.45229579
129ERBB40.45166617
130DMPK0.44082001
131TTK0.44064839
132MAP3K100.43487646
133CLK10.42858045
134BRSK10.42240230
135SGK20.41225511
136STK240.40797646
137PRKAA20.40409514
138STK100.38880966
139STK40.38747971
140AURKB0.37660200
141CHEK10.37392496
142PDPK10.37366733
143CAMKK20.36416458
144MAPKAPK30.35359839
145JAK10.32389032
146BMX0.31989809
147IRAK20.31081967

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.46361629
2Chronic myeloid leukemia_Homo sapiens_hsa052202.23768437
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.17079209
4Type II diabetes mellitus_Homo sapiens_hsa049301.99855293
5Thyroid cancer_Homo sapiens_hsa052161.97996120
6Insulin secretion_Homo sapiens_hsa049111.94588365
7Bladder cancer_Homo sapiens_hsa052191.94027509
8Long-term potentiation_Homo sapiens_hsa047201.90657071
9Small cell lung cancer_Homo sapiens_hsa052221.85538773
10Pancreatic cancer_Homo sapiens_hsa052121.80763241
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77433766
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76361839
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75989308
14Glucagon signaling pathway_Homo sapiens_hsa049221.63611214
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62031584
16ECM-receptor interaction_Homo sapiens_hsa045121.60403827
17Proteoglycans in cancer_Homo sapiens_hsa052051.59511306
18Amphetamine addiction_Homo sapiens_hsa050311.58891926
19mTOR signaling pathway_Homo sapiens_hsa041501.55277430
20Renal cell carcinoma_Homo sapiens_hsa052111.55095809
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46484316
22MicroRNAs in cancer_Homo sapiens_hsa052061.46350410
23Circadian entrainment_Homo sapiens_hsa047131.43412694
24Dopaminergic synapse_Homo sapiens_hsa047281.42637003
25Estrogen signaling pathway_Homo sapiens_hsa049151.41923863
26Acute myeloid leukemia_Homo sapiens_hsa052211.40926754
27Prostate cancer_Homo sapiens_hsa052151.40156591
28Pentose phosphate pathway_Homo sapiens_hsa000301.39125163
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38699091
30Selenocompound metabolism_Homo sapiens_hsa004501.36169451
31Synaptic vesicle cycle_Homo sapiens_hsa047211.36168531
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35963292
33Nicotine addiction_Homo sapiens_hsa050331.34584363
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34463409
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32365450
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29981522
37Arginine biosynthesis_Homo sapiens_hsa002201.29838614
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29769835
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29459123
40Glioma_Homo sapiens_hsa052141.27864282
41Olfactory transduction_Homo sapiens_hsa047401.26988762
42VEGF signaling pathway_Homo sapiens_hsa043701.26346023
43Insulin signaling pathway_Homo sapiens_hsa049101.25344223
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24833543
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24445909
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.21606871
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18740645
48Endometrial cancer_Homo sapiens_hsa052131.14298690
49Butanoate metabolism_Homo sapiens_hsa006501.14029056
50Insulin resistance_Homo sapiens_hsa049311.12296814
51Cholinergic synapse_Homo sapiens_hsa047251.12063093
52Cell cycle_Homo sapiens_hsa041101.10868384
53GnRH signaling pathway_Homo sapiens_hsa049121.10122784
54GABAergic synapse_Homo sapiens_hsa047271.09639483
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08525101
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06448768
57Cocaine addiction_Homo sapiens_hsa050301.05594009
58Bile secretion_Homo sapiens_hsa049761.05266652
59Amoebiasis_Homo sapiens_hsa051461.04413963
60Glutamatergic synapse_Homo sapiens_hsa047241.04397991
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03948158
62Oocyte meiosis_Homo sapiens_hsa041141.03932953
63Dorso-ventral axis formation_Homo sapiens_hsa043201.03723370
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03442615
65Oxytocin signaling pathway_Homo sapiens_hsa049211.03144525
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01115547
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99744848
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98699194
69Renin secretion_Homo sapiens_hsa049240.98237018
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97972283
71Lysine degradation_Homo sapiens_hsa003100.97804406
72AMPK signaling pathway_Homo sapiens_hsa041520.97243984
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.96939861
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96077992
75Fatty acid biosynthesis_Homo sapiens_hsa000610.95219720
76Vitamin B6 metabolism_Homo sapiens_hsa007500.93414212
77Other glycan degradation_Homo sapiens_hsa005110.92857629
78Fructose and mannose metabolism_Homo sapiens_hsa000510.92785237
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92716164
80Gap junction_Homo sapiens_hsa045400.92229289
81Long-term depression_Homo sapiens_hsa047300.90500819
82Viral carcinogenesis_Homo sapiens_hsa052030.89558105
83Galactose metabolism_Homo sapiens_hsa000520.88757747
84Morphine addiction_Homo sapiens_hsa050320.88468549
85Melanoma_Homo sapiens_hsa052180.87255011
86Salivary secretion_Homo sapiens_hsa049700.87011915
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86800386
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.86122234
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85601601
90Gastric acid secretion_Homo sapiens_hsa049710.83112250
91Thyroid hormone synthesis_Homo sapiens_hsa049180.82688567
92Alcoholism_Homo sapiens_hsa050340.81520038
93Melanogenesis_Homo sapiens_hsa049160.80641241
94ErbB signaling pathway_Homo sapiens_hsa040120.79587565
95DNA replication_Homo sapiens_hsa030300.78783967
96Hepatitis B_Homo sapiens_hsa051610.78495772
97Dilated cardiomyopathy_Homo sapiens_hsa054140.77892002
98* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77512035
99Shigellosis_Homo sapiens_hsa051310.75415617
100TGF-beta signaling pathway_Homo sapiens_hsa043500.74702610
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.74679173
102Starch and sucrose metabolism_Homo sapiens_hsa005000.74582021
103Prolactin signaling pathway_Homo sapiens_hsa049170.74322262
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74145308
105N-Glycan biosynthesis_Homo sapiens_hsa005100.74100772
106Prion diseases_Homo sapiens_hsa050200.73975323
107Adherens junction_Homo sapiens_hsa045200.73090024
108Taste transduction_Homo sapiens_hsa047420.72620998
109Apoptosis_Homo sapiens_hsa042100.72397280
110HIF-1 signaling pathway_Homo sapiens_hsa040660.72307258
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71977219
112Hepatitis C_Homo sapiens_hsa051600.71611016
113FoxO signaling pathway_Homo sapiens_hsa040680.71089249
114Notch signaling pathway_Homo sapiens_hsa043300.70774570
115Hippo signaling pathway_Homo sapiens_hsa043900.70127970
116mRNA surveillance pathway_Homo sapiens_hsa030150.69758609
117Pathways in cancer_Homo sapiens_hsa052000.69465500
118cAMP signaling pathway_Homo sapiens_hsa040240.69393452
119Fatty acid degradation_Homo sapiens_hsa000710.68531692
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67758551
121Inositol phosphate metabolism_Homo sapiens_hsa005620.67035953
122Carbon metabolism_Homo sapiens_hsa012000.66763227
123Circadian rhythm_Homo sapiens_hsa047100.66162459
124Choline metabolism in cancer_Homo sapiens_hsa052310.66072117
125Fatty acid metabolism_Homo sapiens_hsa012120.65933486
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.64994283
127Propanoate metabolism_Homo sapiens_hsa006400.64129466
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63362303
129Non-small cell lung cancer_Homo sapiens_hsa052230.62966260
130RNA transport_Homo sapiens_hsa030130.62956012
131Focal adhesion_Homo sapiens_hsa045100.61424184
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61276624
133One carbon pool by folate_Homo sapiens_hsa006700.61253562
134Tight junction_Homo sapiens_hsa045300.61119083
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60634256
136Axon guidance_Homo sapiens_hsa043600.59167233
137Biosynthesis of amino acids_Homo sapiens_hsa012300.59132811
138B cell receptor signaling pathway_Homo sapiens_hsa046620.58903109
139Colorectal cancer_Homo sapiens_hsa052100.58581684
140Pyruvate metabolism_Homo sapiens_hsa006200.58541925
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57827784
142HTLV-I infection_Homo sapiens_hsa051660.57442006
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.56830047
144PPAR signaling pathway_Homo sapiens_hsa033200.56697382
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.54968632
146Calcium signaling pathway_Homo sapiens_hsa040200.54689456
147Tryptophan metabolism_Homo sapiens_hsa003800.54304128
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53656600
149p53 signaling pathway_Homo sapiens_hsa041150.52336953
150Vibrio cholerae infection_Homo sapiens_hsa051100.51738171
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49664176
152TNF signaling pathway_Homo sapiens_hsa046680.48254331
153Nucleotide excision repair_Homo sapiens_hsa034200.45174328

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