ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	replication fork processing (GO:0031297)	4.68758509
2	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.94729961
3	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.94729961
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.81938573
5	DNA double-strand break processing (GO:0000729)	3.66415302
6	chromatin remodeling at centromere (GO:0031055)	3.62189467
7	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.57870542
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.57448622
9	NADH dehydrogenase complex assembly (GO:0010257)	3.57448622
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.57448622
11	protein complex biogenesis (GO:0070271)	3.56906221
12	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.56445896
13	mitochondrial respiratory chain complex assembly (GO:0033108)	3.50030748
14	respiratory chain complex IV assembly (GO:0008535)	3.48318623
15	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.47436139
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.46551382
17	proteasome assembly (GO:0043248)	3.41448002
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.38071392
19	DNA replication checkpoint (GO:0000076)	3.37819900
20	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.35676561
21	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.35676561
22	regulation of translation, ncRNA-mediated (GO:0045974)	3.35676561
23	CENP-A containing nucleosome assembly (GO:0034080)	3.34092852
24	regulation of mitotic spindle checkpoint (GO:1903504)	3.25611235
25	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.25611235
26	water-soluble vitamin biosynthetic process (GO:0042364)	3.20905152
27	DNA strand renaturation (GO:0000733)	3.19614380
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.18602806
29	protein-cofactor linkage (GO:0018065)	3.17455579
30	cytochrome complex assembly (GO:0017004)	3.13286288
31	peptidyl-histidine modification (GO:0018202)	3.11702465
32	histone exchange (GO:0043486)	3.11647628
33	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.11537129
34	ATP synthesis coupled proton transport (GO:0015986)	3.11537129
35	recombinational repair (GO:0000725)	3.11080253
36	double-strand break repair via homologous recombination (GO:0000724)	3.09589416
37	nonmotile primary cilium assembly (GO:0035058)	3.08586202
38	DNA damage response, detection of DNA damage (GO:0042769)	3.02624008
39	DNA deamination (GO:0045006)	2.98616823
40	protein K6-linked ubiquitination (GO:0085020)	2.96468700
41	kidney morphogenesis (GO:0060993)	2.96035521
42	epithelial cilium movement (GO:0003351)	2.95218224
43	maturation of 5.8S rRNA (GO:0000460)	2.95039571
44	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.94524287
45	chaperone-mediated protein transport (GO:0072321)	2.93008955
46	neural tube formation (GO:0001841)	2.92661783
47	resolution of meiotic recombination intermediates (GO:0000712)	2.91271019
48	reciprocal meiotic recombination (GO:0007131)	2.88626093
49	reciprocal DNA recombination (GO:0035825)	2.88626093
50	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.80652549
51	pseudouridine synthesis (GO:0001522)	2.79532179
52	termination of RNA polymerase III transcription (GO:0006386)	2.76315942
53	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.76315942
54	synapsis (GO:0007129)	2.75803820
55	intraciliary transport (GO:0042073)	2.73273579
56	rRNA modification (GO:0000154)	2.71575859
57	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70584235
58	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70584235
59	kinetochore assembly (GO:0051382)	2.69417929
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.68970884
61	ubiquinone biosynthetic process (GO:0006744)	2.68556750
62	ubiquinone metabolic process (GO:0006743)	2.66514248
63	behavioral response to nicotine (GO:0035095)	2.64198854
64	regulation of DNA endoreduplication (GO:0032875)	2.60620850
65	electron transport chain (GO:0022900)	2.59881893
66	respiratory electron transport chain (GO:0022904)	2.58990529
67	maturation of SSU-rRNA (GO:0030490)	2.57613696
68	kinetochore organization (GO:0051383)	2.56888836
69	postreplication repair (GO:0006301)	2.56340610
70	mitochondrial RNA metabolic process (GO:0000959)	2.54691832
71	intracellular protein transmembrane import (GO:0044743)	2.54186245
72	cilium movement (GO:0003341)	2.54175996
73	ncRNA catabolic process (GO:0034661)	2.54143729
74	purine nucleobase biosynthetic process (GO:0009113)	2.52684709
75	regulation of meiosis I (GO:0060631)	2.52295013
76	protein neddylation (GO:0045116)	2.51443114
77	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.50716384
78	isotype switching (GO:0045190)	2.50716384
79	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.50716384
80	DNA catabolic process, exonucleolytic (GO:0000738)	2.50684293
81	regulation of mitochondrial translation (GO:0070129)	2.50338305
82	histone mRNA metabolic process (GO:0008334)	2.49933269
83	somatic diversification of immunoglobulins (GO:0016445)	2.49130962
84	rRNA methylation (GO:0031167)	2.48155696
85	nucleobase biosynthetic process (GO:0046112)	2.47441068
86	ribosomal small subunit assembly (GO:0000028)	2.44656538
87	DNA ligation (GO:0006266)	2.42965694
88	DNA replication-independent nucleosome assembly (GO:0006336)	2.42211852
89	DNA replication-independent nucleosome organization (GO:0034724)	2.42211852
90	translesion synthesis (GO:0019985)	2.41212013
91	negative regulation of telomere maintenance (GO:0032205)	2.40989336
92	cullin deneddylation (GO:0010388)	2.40174191
93	tRNA processing (GO:0008033)	2.39929090
94	indolalkylamine metabolic process (GO:0006586)	2.39452980
95	negative regulation of DNA recombination (GO:0045910)	2.39308075
96	cilium morphogenesis (GO:0060271)	2.38541327
97	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.37817633
98	DNA replication-dependent nucleosome assembly (GO:0006335)	2.37408475
99	DNA replication-dependent nucleosome organization (GO:0034723)	2.37408475
100	double-strand break repair (GO:0006302)	2.34361383

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.22769038
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.94287035
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89095944
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.88237951
5	E2F7_22180533_ChIP-Seq_HELA_Human	2.86915708
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.84115596
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.79562978
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.79075568
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66214455
10	VDR_22108803_ChIP-Seq_LS180_Human	2.61365202
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58174761
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.57966737
13	EWS_26573619_Chip-Seq_HEK293_Human	2.51107139
14	FUS_26573619_Chip-Seq_HEK293_Human	2.49387232
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.41984265
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.27821434
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.21672577
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12269486
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.11650578
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.03451884
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.98019650
22	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.97372121
23	P300_19829295_ChIP-Seq_ESCs_Human	1.95507783
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.91159545
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.87788498
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87623794
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81732845
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.81443409
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.81266152
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.80758443
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80284423
32	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.72136629
33	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.71873643
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.70515658
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.66580576
36	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64973713
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61692064
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52447910
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49613567
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.44547801
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.41920285
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39572835
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38728134
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38315526
45	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.37676856
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.32608441
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31367318
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31236200
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30659039
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27893267
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26644662
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25467347
53	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.24070113
54	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.22878450
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22488076
56	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.21683906
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18093679
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17859656
59	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.16830088
60	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.16615028
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.15464587
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14980189
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14516417
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.14516417
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.13733907
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12575713
67	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12388783
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11859168
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11859168
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09655969
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09513096
72	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09444922
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08836963
74	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08680150
75	STAT3_23295773_ChIP-Seq_U87_Human	1.08466224
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08164520
77	EZH2_22144423_ChIP-Seq_EOC_Human	1.07324984
78	TTF2_22483619_ChIP-Seq_HELA_Human	1.06952641
79	BCAT_22108803_ChIP-Seq_LS180_Human	1.05281954
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04155929
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03870009
82	AR_25329375_ChIP-Seq_VCAP_Human	1.03598736
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01464667
84	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.01372475
85	TCF4_23295773_ChIP-Seq_U87_Human	1.01097551
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00456782
87	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00208319
88	TCF4_22108803_ChIP-Seq_LS180_Human	0.99716632
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96456083
90	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96456083
91	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95524462
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94669972
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93159736
94	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93043149
95	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93043149
96	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.92505193
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91503609
98	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.90854531
99	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.90597080
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90419680

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.82037060
2	MP0008877_abnormal_DNA_methylation	2.87551760
3	MP0008058_abnormal_DNA_repair	2.85008367
4	MP0010094_abnormal_chromosome_stability	2.81581149
5	MP0002938_white_spotting	2.73575240
6	MP0003136_yellow_coat_color	2.34816092
7	MP0003693_abnormal_embryo_hatching	2.25874755
8	MP0002102_abnormal_ear_morphology	2.25039239
9	MP0008057_abnormal_DNA_replication	2.15207308
10	MP0003880_abnormal_central_pattern	2.05154377
11	MP0009697_abnormal_copulation	1.97058340
12	MP0001293_anophthalmia	1.91220575
13	MP0003195_calcinosis	1.89042788
14	MP0000566_synostosis	1.77379797
15	MP0003718_maternal_effect	1.75873875
16	MP0003890_abnormal_embryonic-extraembry	1.75268400
17	MP0004147_increased_porphyrin_level	1.71281416
18	MP0006072_abnormal_retinal_apoptosis	1.70439190
19	MP0001984_abnormal_olfaction	1.68639251
20	MP0001529_abnormal_vocalization	1.63672948
21	MP0005551_abnormal_eye_electrophysiolog	1.57539111
22	MP0002837_dystrophic_cardiac_calcinosis	1.54099625
23	MP0000372_irregular_coat_pigmentation	1.54060780
24	MP0004133_heterotaxia	1.54016360
25	MP0002736_abnormal_nociception_after	1.52855071
26	MP0009046_muscle_twitch	1.52753367
27	MP0003111_abnormal_nucleus_morphology	1.52586998
28	MP0010030_abnormal_orbit_morphology	1.49690485
29	MP0003937_abnormal_limbs/digits/tail_de	1.48784731
30	MP0008995_early_reproductive_senescence	1.46677351
31	MP0000631_abnormal_neuroendocrine_gland	1.45858843
32	MP0001485_abnormal_pinna_reflex	1.44479108
33	MP0003121_genomic_imprinting	1.38101863
34	MP0004957_abnormal_blastocyst_morpholog	1.38044811
35	MP0001968_abnormal_touch/_nociception	1.36930812
36	MP0005084_abnormal_gallbladder_morpholo	1.35063012
37	MP0002160_abnormal_reproductive_system	1.34253563
38	MP0008789_abnormal_olfactory_epithelium	1.31049673
39	MP0003567_abnormal_fetal_cardiomyocyte	1.30328621
40	MP0002234_abnormal_pharynx_morphology	1.30220266
41	MP0005253_abnormal_eye_physiology	1.27878019
42	MP0003786_premature_aging	1.25555344
43	MP0003646_muscle_fatigue	1.24522226
44	MP0002277_abnormal_respiratory_mucosa	1.23855607
45	MP0005075_abnormal_melanosome_morpholog	1.22099796
46	MP0003122_maternal_imprinting	1.20726726
47	MP0003119_abnormal_digestive_system	1.19111825
48	MP0004142_abnormal_muscle_tone	1.17420354
49	MP0003077_abnormal_cell_cycle	1.17036039
50	MP0001929_abnormal_gametogenesis	1.16682543
51	MP0002210_abnormal_sex_determination	1.15907237
52	MP0001286_abnormal_eye_development	1.15213950
53	MP0008872_abnormal_physiological_respon	1.14725248
54	MP0006035_abnormal_mitochondrial_morpho	1.13244596
55	MP0001346_abnormal_lacrimal_gland	1.12609083
56	MP0002233_abnormal_nose_morphology	1.09593256
57	MP0003787_abnormal_imprinting	1.08620794
58	MP0000049_abnormal_middle_ear	1.08350116
59	MP0005389_reproductive_system_phenotype	1.05302953
60	MP0002697_abnormal_eye_size	1.05221213
61	MP0005499_abnormal_olfactory_system	1.05126600
62	MP0005394_taste/olfaction_phenotype	1.05126600
63	MP0008932_abnormal_embryonic_tissue	1.04944141
64	MP0002876_abnormal_thyroid_physiology	1.03379367
65	MP0006276_abnormal_autonomic_nervous	1.03350721
66	MP0006036_abnormal_mitochondrial_physio	1.02972191
67	MP0000653_abnormal_sex_gland	1.01898861
68	MP0001986_abnormal_taste_sensitivity	1.01263708
69	MP0001145_abnormal_male_reproductive	1.00538831
70	MP0000427_abnormal_hair_cycle	1.00342707
71	MP0002095_abnormal_skin_pigmentation	1.00033879
72	MP0003878_abnormal_ear_physiology	0.99843557
73	MP0005377_hearing/vestibular/ear_phenot	0.99843557
74	MP0008875_abnormal_xenobiotic_pharmacok	0.97535136
75	MP0005195_abnormal_posterior_eye	0.96974505
76	MP0005174_abnormal_tail_pigmentation	0.96604101
77	MP0003938_abnormal_ear_development	0.96508178
78	MP0003698_abnormal_male_reproductive	0.96311032
79	MP0001486_abnormal_startle_reflex	0.95978573
80	MP0001764_abnormal_homeostasis	0.95452049
81	MP0002751_abnormal_autonomic_nervous	0.95349925
82	MP0000647_abnormal_sebaceous_gland	0.92642034
83	MP0009745_abnormal_behavioral_response	0.92005165
84	MP0000778_abnormal_nervous_system	0.91615030
85	MP0002272_abnormal_nervous_system	0.91203931
86	MP0009379_abnormal_foot_pigmentation	0.91036892
87	MP0005367_renal/urinary_system_phenotyp	0.88552984
88	MP0000516_abnormal_urinary_system	0.88552984
89	MP0005391_vision/eye_phenotype	0.87681999
90	MP0002163_abnormal_gland_morphology	0.87058724
91	MP0005646_abnormal_pituitary_gland	0.86720542
92	MP0002090_abnormal_vision	0.84464634
93	MP0001119_abnormal_female_reproductive	0.84252721
94	MP0001324_abnormal_eye_pigmentation	0.83706518
95	MP0002638_abnormal_pupillary_reflex	0.82670300
96	MP0005645_abnormal_hypothalamus_physiol	0.80642820
97	MP0001919_abnormal_reproductive_system	0.80454492
98	MP0004215_abnormal_myocardial_fiber	0.79939326
99	MP0008007_abnormal_cellular_replicative	0.78774383
100	MP0005395_other_phenotype	0.78130802

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.59933846
2	Pancreatic fibrosis (HP:0100732)	3.59603110
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.51459558
4	Chromsome breakage (HP:0040012)	3.34146338
5	True hermaphroditism (HP:0010459)	3.26564604
6	Meckel diverticulum (HP:0002245)	3.24275084
7	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.22600102
8	Abnormality of midbrain morphology (HP:0002418)	3.20805501
9	Molar tooth sign on MRI (HP:0002419)	3.20805501
10	Reticulocytopenia (HP:0001896)	3.16312333
11	Abnormality of the ileum (HP:0001549)	3.15886244
12	Abnormality of chromosome stability (HP:0003220)	3.01280312
13	Acute necrotizing encephalopathy (HP:0006965)	2.98529153
14	Nephronophthisis (HP:0000090)	2.95871914
15	Medial flaring of the eyebrow (HP:0010747)	2.87500808
16	Acute encephalopathy (HP:0006846)	2.68260436
17	Increased CSF lactate (HP:0002490)	2.64745145
18	Mitochondrial inheritance (HP:0001427)	2.64102802
19	Ectopic kidney (HP:0000086)	2.59069006
20	Progressive macrocephaly (HP:0004481)	2.57411906
21	Colon cancer (HP:0003003)	2.55663691
22	Absent thumb (HP:0009777)	2.54980350
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.53911898
24	Abnormality of the preputium (HP:0100587)	2.53033627
25	Duplicated collecting system (HP:0000081)	2.52979899
26	Abnormality of the renal medulla (HP:0100957)	2.45094445
27	Abnormality of the labia minora (HP:0012880)	2.45054011
28	Abnormality of the renal collecting system (HP:0004742)	2.40560588
29	Hepatocellular necrosis (HP:0001404)	2.40539470
30	Triphalangeal thumb (HP:0001199)	2.38795759
31	Sclerocornea (HP:0000647)	2.37489634
32	Hepatic necrosis (HP:0002605)	2.37195645
33	Congenital primary aphakia (HP:0007707)	2.36886410
34	Bile duct proliferation (HP:0001408)	2.36405776
35	Abnormal biliary tract physiology (HP:0012439)	2.36405776
36	Abnormality of the renal cortex (HP:0011035)	2.34093139
37	Gait imbalance (HP:0002141)	2.30343974
38	Chronic hepatic failure (HP:0100626)	2.29956985
39	Clubbing of toes (HP:0100760)	2.29178925
40	Intestinal atresia (HP:0011100)	2.26257541
41	Septo-optic dysplasia (HP:0100842)	2.22563778
42	Genital tract atresia (HP:0001827)	2.22503149
43	Anencephaly (HP:0002323)	2.22364642
44	Abnormality of alanine metabolism (HP:0010916)	2.21932795
45	Hyperalaninemia (HP:0003348)	2.21932795
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.21932795
47	Type II lissencephaly (HP:0007260)	2.21109027
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20964534
49	3-Methylglutaconic aciduria (HP:0003535)	2.15103622
50	Small intestinal stenosis (HP:0012848)	2.14444776
51	Duodenal stenosis (HP:0100867)	2.14444776
52	Cystic liver disease (HP:0006706)	2.14304163
53	Vaginal atresia (HP:0000148)	2.13430925
54	Nephrogenic diabetes insipidus (HP:0009806)	2.09433159
55	Tubular atrophy (HP:0000092)	2.08218641
56	Sloping forehead (HP:0000340)	2.05428683
57	Methylmalonic acidemia (HP:0002912)	2.05099455
58	Optic nerve hypoplasia (HP:0000609)	2.02926713
59	Abnormality of the duodenum (HP:0002246)	2.02329612
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.02272988
61	Pendular nystagmus (HP:0012043)	2.01045597
62	Increased serum lactate (HP:0002151)	1.98736159
63	Hypothermia (HP:0002045)	1.98662960
64	Increased hepatocellular lipid droplets (HP:0006565)	1.97918418
65	Cerebral edema (HP:0002181)	1.96788623
66	Abolished electroretinogram (ERG) (HP:0000550)	1.96655876
67	Postaxial foot polydactyly (HP:0001830)	1.96641511
68	Congenital stationary night blindness (HP:0007642)	1.96385557
69	Hypoplasia of the pons (HP:0012110)	1.96333525
70	Congenital, generalized hypertrichosis (HP:0004540)	1.95075334
71	Abnormality of the pons (HP:0007361)	1.94303418
72	Abnormal rod and cone electroretinograms (HP:0008323)	1.93423122
73	Preaxial hand polydactyly (HP:0001177)	1.92957666
74	Hyperglycinemia (HP:0002154)	1.92623427
75	Astigmatism (HP:0000483)	1.90766093
76	Renal cortical cysts (HP:0000803)	1.88755722
77	Male pseudohermaphroditism (HP:0000037)	1.88326274
78	Abnormality of the carotid arteries (HP:0005344)	1.85779811
79	Volvulus (HP:0002580)	1.85465910
80	Abnormal number of erythroid precursors (HP:0012131)	1.84289003
81	Dandy-Walker malformation (HP:0001305)	1.83834082
82	Absent radius (HP:0003974)	1.83830819
83	Gastrointestinal atresia (HP:0002589)	1.83329590
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.83324555
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83324555
86	Birth length less than 3rd percentile (HP:0003561)	1.82314348
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79848754
88	Absent/shortened dynein arms (HP:0200106)	1.79485593
89	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79485593
90	Abnormal ciliary motility (HP:0012262)	1.79233959
91	Horseshoe kidney (HP:0000085)	1.79079578
92	Aganglionic megacolon (HP:0002251)	1.78410778
93	Cerebellar dysplasia (HP:0007033)	1.78275946
94	Poor coordination (HP:0002370)	1.78138754
95	Abnormal lung lobation (HP:0002101)	1.76936951
96	Pancytopenia (HP:0001876)	1.75902436
97	Attenuation of retinal blood vessels (HP:0007843)	1.75759902
98	Renal hypoplasia (HP:0000089)	1.75295589
99	Aplasia involving forearm bones (HP:0009822)	1.74991426
100	Absent forearm bone (HP:0003953)	1.74991426

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.89834845
2	ZAK	2.99876296
3	BMPR1B	2.93627823
4	WNK3	2.90707941
5	INSRR	2.58505465
6	MKNK2	2.51628603
7	NUAK1	2.42838241
8	CDC7	2.34324874
9	BUB1	2.14298986
10	VRK2	1.99672701
11	MAP4K2	1.98935127
12	ACVR1B	1.95580897
13	TRIM28	1.92382395
14	EPHA4	1.88885941
15	SRPK1	1.87627867
16	VRK1	1.86633906
17	MKNK1	1.84898017
18	GRK1	1.73009714
19	TNIK	1.71462965
20	PLK3	1.69489526
21	EIF2AK3	1.68712404
22	TLK1	1.66997233
23	ADRBK2	1.66836110
24	MST4	1.63880440
25	PLK4	1.63378818
26	PNCK	1.61626121
27	STK16	1.61359086
28	PASK	1.51386344
29	MAP3K4	1.50598836
30	BCKDK	1.49215902
31	BRSK2	1.43933408
32	WEE1	1.43456362
33	TSSK6	1.39739174
34	PINK1	1.37602714
35	TGFBR1	1.31576500
36	TTK	1.31241707
37	STK39	1.29833715
38	FGFR2	1.19428548
39	MAPK13	1.16213915
40	PLK1	1.13719305
41	NME1	1.11617868
42	TIE1	1.09562564
43	CASK	1.08018095
44	PDK2	1.06257189
45	TAF1	1.03711595
46	PLK2	0.99020293
47	ATR	0.98431346
48	OXSR1	0.96417896
49	STK3	0.96042000
50	DYRK2	0.95530208
51	TAOK3	0.93768802
52	STK38L	0.92485465
53	WNK4	0.90810286
54	PRKCG	0.89081658
55	CHEK2	0.87385292
56	MAP2K7	0.86537969
57	PRKCE	0.85974923
58	CSNK1G1	0.84794491
59	NEK1	0.79203547
60	ATM	0.78040113
61	MAP3K12	0.73478706
62	PBK	0.72475380
63	ERBB3	0.66977570
64	CAMK1G	0.65001359
65	CSNK1G3	0.61868560
66	BCR	0.61758115
67	CSNK1G2	0.58526603
68	AURKB	0.57135956
69	PAK3	0.53287238
70	CSNK1A1L	0.50690386
71	CHEK1	0.50385737
72	NLK	0.48932101
73	PIK3CG	0.47758488
74	OBSCN	0.47153900
75	EIF2AK2	0.46753299
76	CDK3	0.46279683
77	CSNK1A1	0.46107947
78	ADRBK1	0.45687437
79	RPS6KA5	0.45261202
80	CCNB1	0.44789775
81	RPS6KA4	0.43912749
82	BRD4	0.42276148
83	DYRK3	0.42111816
84	CSNK2A1	0.41610880
85	FGFR1	0.40475824
86	TXK	0.39825359
87	CDK8	0.39578671
88	FLT3	0.39207903
89	CSNK2A2	0.39088320
90	CSNK1E	0.38257917
91	CDK19	0.36611680
92	BRSK1	0.34407493
93	PIK3CA	0.33599235
94	CAMK1	0.33485735
95	CAMK1D	0.33396079
96	PRKDC	0.32821624
97	PRKCQ	0.32697396
98	NEK2	0.32430473
99	CSNK1D	0.29757350
100	PKN1	0.28914992

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.28863128
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.02136666
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.91529012
4	RNA polymerase_Homo sapiens_hsa03020	2.88791478
5	Protein export_Homo sapiens_hsa03060	2.72067709
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.63448085
7	Mismatch repair_Homo sapiens_hsa03430	2.53977983
8	Proteasome_Homo sapiens_hsa03050	2.49137565
9	Ribosome_Homo sapiens_hsa03010	2.42625395
10	Parkinsons disease_Homo sapiens_hsa05012	2.38361596
11	DNA replication_Homo sapiens_hsa03030	2.22420993
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17426126
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.08390311
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.04647813
15	Basal transcription factors_Homo sapiens_hsa03022	1.99823887
16	Huntingtons disease_Homo sapiens_hsa05016	1.94645154
17	RNA degradation_Homo sapiens_hsa03018	1.94230492
18	One carbon pool by folate_Homo sapiens_hsa00670	1.87929331
19	Propanoate metabolism_Homo sapiens_hsa00640	1.84707013
20	Butanoate metabolism_Homo sapiens_hsa00650	1.84543662
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.71568130
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.63598907
23	RNA transport_Homo sapiens_hsa03013	1.56952404
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.52695243
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.48348396
26	Alzheimers disease_Homo sapiens_hsa05010	1.48252834
27	Phototransduction_Homo sapiens_hsa04744	1.45404898
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.44678963
29	Spliceosome_Homo sapiens_hsa03040	1.38589200
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.37737534
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35432093
32	Base excision repair_Homo sapiens_hsa03410	1.34649183
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32120786
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30714744
35	Purine metabolism_Homo sapiens_hsa00230	1.27441048
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23284520
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.19077588
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.17159780
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.17084715
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13241404
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.11462116
42	Steroid biosynthesis_Homo sapiens_hsa00100	1.09327087
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08945899
44	Cell cycle_Homo sapiens_hsa04110	1.06786736
45	Pyruvate metabolism_Homo sapiens_hsa00620	1.05619050
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00774998
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.98656707
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95871066
49	Nicotine addiction_Homo sapiens_hsa05033	0.91164663
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.89708693
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89445917
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87181366
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.86988032
54	Peroxisome_Homo sapiens_hsa04146	0.85540647
55	Sulfur relay system_Homo sapiens_hsa04122	0.84237816
56	Basal cell carcinoma_Homo sapiens_hsa05217	0.80407022
57	Metabolic pathways_Homo sapiens_hsa01100	0.79881628
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.78812956
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77131637
60	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.72880302
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.72585551
62	Olfactory transduction_Homo sapiens_hsa04740	0.71928920
63	Taste transduction_Homo sapiens_hsa04742	0.71918098
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71106441
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.70893574
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64688216
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64634491
68	Caffeine metabolism_Homo sapiens_hsa00232	0.62373674
69	Retinol metabolism_Homo sapiens_hsa00830	0.61594815
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59158073
71	Fatty acid elongation_Homo sapiens_hsa00062	0.58218377
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58192264
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57562377
74	Glutathione metabolism_Homo sapiens_hsa00480	0.57498844
75	Folate biosynthesis_Homo sapiens_hsa00790	0.57303060
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.55905521
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54390568
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53302856
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52249983
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.50501321
81	Oocyte meiosis_Homo sapiens_hsa04114	0.49219337
82	mRNA surveillance pathway_Homo sapiens_hsa03015	0.48877954
83	Sulfur metabolism_Homo sapiens_hsa00920	0.48514041
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48467193
85	Regulation of autophagy_Homo sapiens_hsa04140	0.47022311
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45951340
87	p53 signaling pathway_Homo sapiens_hsa04115	0.43804149
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42395513
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41748429
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.38730220
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36664674
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.36527909
93	Fatty acid degradation_Homo sapiens_hsa00071	0.31735849
94	Alcoholism_Homo sapiens_hsa05034	0.30475002
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.29320516
96	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.28943820
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.27253080
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.26583113
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25541137
100	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.25428424

UBE3D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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