UBL4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.29867660
2ATP synthesis coupled proton transport (GO:0015986)5.72609247
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.72609247
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.25675073
5NADH metabolic process (GO:0006734)5.11891721
6respiratory electron transport chain (GO:0022904)5.11720489
7negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.01211515
8proline biosynthetic process (GO:0006561)5.00504679
9electron transport chain (GO:0022900)4.99339511
10cullin deneddylation (GO:0010388)4.97465796
11tricarboxylic acid cycle (GO:0006099)4.96436266
12oxidative phosphorylation (GO:0006119)4.93485892
13protein maturation by protein folding (GO:0022417)4.93071903
14L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.92467973
15proteasome assembly (GO:0043248)4.87424543
16protein complex biogenesis (GO:0070271)4.65444461
17protein deneddylation (GO:0000338)4.64327580
18DNA unwinding involved in DNA replication (GO:0006268)4.60242433
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.59706665
20mitochondrial respiratory chain complex I assembly (GO:0032981)4.59706665
21NADH dehydrogenase complex assembly (GO:0010257)4.59706665
22DNA deamination (GO:0045006)4.59364838
23chaperone-mediated protein transport (GO:0072321)4.49346913
24mitochondrial respiratory chain complex assembly (GO:0033108)4.33262428
25positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.13646422
26L-methionine salvage (GO:0071267)4.04183575
27L-methionine biosynthetic process (GO:0071265)4.04183575
28amino acid salvage (GO:0043102)4.04183575
29regulation of mitochondrial translation (GO:0070129)3.95835008
30pentose-phosphate shunt (GO:0006098)3.85287719
31oxaloacetate metabolic process (GO:0006107)3.79712907
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77821639
33peptidyl-arginine omega-N-methylation (GO:0035247)3.76974946
34regulation of cellular amino acid metabolic process (GO:0006521)3.76447587
35GDP-mannose metabolic process (GO:0019673)3.74097576
36regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73116391
37deoxyribose phosphate biosynthetic process (GO:0046385)3.71410611
382-deoxyribonucleotide biosynthetic process (GO:0009265)3.71410611
39DNA strand elongation involved in DNA replication (GO:0006271)3.70978924
40ribosomal small subunit assembly (GO:0000028)3.70258036
41DNA strand elongation (GO:0022616)3.69861964
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.68634723
43protein targeting to mitochondrion (GO:0006626)3.68567465
44regulation of acyl-CoA biosynthetic process (GO:0050812)3.64496966
45deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.60728761
46aerobic respiration (GO:0009060)3.56220394
47respiratory chain complex IV assembly (GO:0008535)3.55349736
48mitotic chromosome condensation (GO:0007076)3.54470451
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.52153877
50termination of RNA polymerase III transcription (GO:0006386)3.52153877
51regulation of cofactor metabolic process (GO:0051193)3.51575291
52regulation of coenzyme metabolic process (GO:0051196)3.51575291
53regulation of translational fidelity (GO:0006450)3.49480499
54nucleobase-containing small molecule interconversion (GO:0015949)3.48637916
55mitochondrial fusion (GO:0008053)3.46758394
56establishment of protein localization to mitochondrion (GO:0072655)3.46528082
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45540257
58ATP biosynthetic process (GO:0006754)3.42590862
59negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.41689132
60succinate metabolic process (GO:0006105)3.41479334
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.40770904
62COPI coating of Golgi vesicle (GO:0048205)3.38682440
63Golgi transport vesicle coating (GO:0048200)3.38682440
64inner mitochondrial membrane organization (GO:0007007)3.38514241
65cytochrome complex assembly (GO:0017004)3.37965519
66guanosine-containing compound biosynthetic process (GO:1901070)3.37091663
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35131337
68nuclear envelope reassembly (GO:0031468)3.33962525
69mitotic nuclear envelope reassembly (GO:0007084)3.33962525
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33620201
71negative regulation of ligase activity (GO:0051352)3.33620201
72galactose catabolic process (GO:0019388)3.33309063
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.30094284
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29514117
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29514117
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29448438
77deoxyribonucleotide biosynthetic process (GO:0009263)3.28585093
78NADPH regeneration (GO:0006740)3.28479225
79retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27577950
80purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27363637
81glucose catabolic process (GO:0006007)3.27336547
82formation of translation preinitiation complex (GO:0001731)3.26652192
83purine nucleobase biosynthetic process (GO:0009113)3.26354153
84protein localization to mitochondrion (GO:0070585)3.25708657
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25534951
86signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25534951
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25534951
88DNA replication initiation (GO:0006270)3.23796994
89signal peptide processing (GO:0006465)3.23597616
90telomere maintenance via semi-conservative replication (GO:0032201)3.23551848
91regulation of early endosome to late endosome transport (GO:2000641)3.22163509
92iron-sulfur cluster assembly (GO:0016226)3.21608699
93metallo-sulfur cluster assembly (GO:0031163)3.21608699
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17878550
95protoporphyrinogen IX metabolic process (GO:0046501)3.17738193
96ATP hydrolysis coupled proton transport (GO:0015991)3.16832471
97energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.16832471
98nucleobase biosynthetic process (GO:0046112)3.15112415
99synaptic vesicle docking involved in exocytosis (GO:0016081)3.15007990
100signal transduction involved in DNA integrity checkpoint (GO:0072401)3.14998084
101signal transduction involved in DNA damage checkpoint (GO:0072422)3.14998084
102regulation of oxidative phosphorylation (GO:0002082)3.13795496
103spliceosomal tri-snRNP complex assembly (GO:0000244)3.13131323
104adenosine receptor signaling pathway (GO:0001973)3.12558677
105hydrogen ion transmembrane transport (GO:1902600)3.12285253
106GMP metabolic process (GO:0046037)3.11268974
107platelet aggregation (GO:0070527)3.10284809
108negative regulation of homotypic cell-cell adhesion (GO:0034111)3.09565017
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09008021
110pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.08647925
111translation (GO:0006412)3.08635303
112antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.08237701
113signal transduction involved in cell cycle checkpoint (GO:0072395)3.08073309
114purine nucleoside monophosphate biosynthetic process (GO:0009127)3.07971286
115purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.07971286
116quinone biosynthetic process (GO:1901663)3.06873061
117ubiquinone biosynthetic process (GO:0006744)3.06873061
118ribonucleoside triphosphate biosynthetic process (GO:0009201)3.03841398
119pentose metabolic process (GO:0019321)3.03240297
120cotranslational protein targeting to membrane (GO:0006613)3.02994397
121proline metabolic process (GO:0006560)3.02169360
122peptidyl-histidine modification (GO:0018202)3.00908116
123protein targeting to ER (GO:0045047)2.98740385
124mitochondrial transport (GO:0006839)2.97644417
125regulation of cellular respiration (GO:0043457)2.97569305
126positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.96909353
127protein neddylation (GO:0045116)2.96837473
128pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96412586
129mitochondrial calcium ion transport (GO:0006851)2.94223161
130protein localization to endoplasmic reticulum (GO:0070972)2.93621102
131histone arginine methylation (GO:0034969)2.93453212
132nucleoside triphosphate biosynthetic process (GO:0009142)2.92774044
133peptidyl-arginine N-methylation (GO:0035246)2.92079040
134peptidyl-arginine methylation (GO:0018216)2.92079040
135negative regulation of erythrocyte differentiation (GO:0045647)2.90081907
136polyamine biosynthetic process (GO:0006596)2.89779716
137positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.89617201
138RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88604060
139tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88604060
140protein localization to endosome (GO:0036010)2.86367269
141nucleoside diphosphate biosynthetic process (GO:0009133)2.86238310
142gluconeogenesis (GO:0006094)2.83595642
143regulation of chromatin binding (GO:0035561)2.82784187
144monosaccharide biosynthetic process (GO:0046364)2.82577935
145glucose 6-phosphate metabolic process (GO:0051156)2.72355884
146barbed-end actin filament capping (GO:0051016)2.72191505
147pyrimidine nucleoside salvage (GO:0043097)2.70878223
148pyrimidine-containing compound salvage (GO:0008655)2.70878223
149nucleotide salvage (GO:0043173)2.66669323
150glycolytic process (GO:0006096)2.64797374
151pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63999875
152hexose biosynthetic process (GO:0019319)2.62623517
153protein complex localization (GO:0031503)2.61738326
154ribosomal small subunit biogenesis (GO:0042274)2.59481156
155cellular protein complex localization (GO:0034629)2.57732567
156pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.57678291
157rRNA transcription (GO:0009303)2.56699339
158folic acid metabolic process (GO:0046655)2.54185170
159protein retention in ER lumen (GO:0006621)2.51777112
160endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.49418564
161regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.46126961
162creatine metabolic process (GO:0006600)2.45764061
163regulation of mitochondrial membrane potential (GO:0051881)2.44853426
164platelet formation (GO:0030220)2.44419416
165cellular response to arsenic-containing substance (GO:0071243)2.42776624
166nuclear pore complex assembly (GO:0051292)2.42179417
167negative regulation of DNA-templated transcription, elongation (GO:0032785)2.39761384
168regulation of translational termination (GO:0006449)2.39308698
169protoporphyrinogen IX biosynthetic process (GO:0006782)2.39044881
170deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.38277561
171regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.38175203
172adherens junction assembly (GO:0034333)2.37758261
173regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.36694424
174regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.33218894
175positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.33218894
176peptidyl-arginine modification (GO:0018195)2.32633646
177apoptotic process involved in morphogenesis (GO:0060561)2.32456174
178negative regulation of cell size (GO:0045792)2.31280959
179telomere maintenance via recombination (GO:0000722)2.30873254
180maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30252476
181snRNA metabolic process (GO:0016073)2.30235180
182focal adhesion assembly (GO:0048041)2.29729858
183cell-substrate adherens junction assembly (GO:0007045)2.29729858
184negative regulation of protein localization to plasma membrane (GO:1903077)2.28671313
185UV protection (GO:0009650)2.28359835
186UMP metabolic process (GO:0046049)2.28213066
187pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.28213066
188UMP biosynthetic process (GO:0006222)2.28213066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.08160896
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.90371982
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.60669002
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.49664325
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.16474780
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.10438707
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.99000583
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.77443822
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.55821426
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.47691195
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.25349581
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10569460
13THAP11_20581084_ChIP-Seq_MESCs_Mouse3.05507964
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04959742
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.84848614
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.60422510
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53744605
18DCP1A_22483619_ChIP-Seq_HELA_Human2.50661396
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.47437172
20VDR_23849224_ChIP-Seq_CD4+_Human2.45516323
21GABP_19822575_ChIP-Seq_HepG2_Human2.41002275
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.40058728
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40045559
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30225422
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24464558
26MYC_22102868_ChIP-Seq_BL_Human2.20689087
27XRN2_22483619_ChIP-Seq_HELA_Human2.18141078
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17607917
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14843351
30FOXP3_21729870_ChIP-Seq_TREG_Human2.13327912
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09725742
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.05183509
33VDR_21846776_ChIP-Seq_THP-1_Human2.04616621
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02040444
35LXR_22292898_ChIP-Seq_THP-1_Human1.94812690
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.89327673
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.88696200
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.87904945
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81411488
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80976628
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79798603
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78354729
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74497014
44GATA1_22025678_ChIP-Seq_K562_Human1.72883405
45TTF2_22483619_ChIP-Seq_HELA_Human1.72439912
46RACK7_27058665_Chip-Seq_MCF-7_Human1.72231979
47CIITA_25753668_ChIP-Seq_RAJI_Human1.68350126
48E2F7_22180533_ChIP-Seq_HELA_Human1.67964156
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66567868
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65509626
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65197570
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64011102
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60210602
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59142151
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57751579
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57196341
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57118366
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56883181
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54578247
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52362356
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50839150
62ELK1_19687146_ChIP-ChIP_HELA_Human1.50425019
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48091494
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.47413213
65* NCOR1_26117541_ChIP-Seq_K562_Human1.45458253
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41938452
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41671601
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41377671
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40063403
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.38420235
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37922958
72P68_20966046_ChIP-Seq_HELA_Human1.35230996
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34130303
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33611732
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.31863493
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29940292
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28275346
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28132735
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26567708
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24687134
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24682421
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24267516
83TCF7_22412390_ChIP-Seq_EML_Mouse1.23642951
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23007878
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20794015
86TBX5_21415370_ChIP-Seq_HL-1_Mouse1.20428422
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19050580
88KDM2B_26808549_Chip-Seq_DND41_Human1.17614517
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17080975
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.16079866
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15728977
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.15294379
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.14478498
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14317737
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.14086178
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12921817
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11689186
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11588570
99MAF_26560356_Chip-Seq_TH1_Human1.10743926
100ATF3_27146783_Chip-Seq_COLON_Human1.09342498
101ZNF263_19887448_ChIP-Seq_K562_Human1.08593022
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07737898
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07169255
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06497285
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05588357
106MAF_26560356_Chip-Seq_TH2_Human1.03932977
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02279018
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00902793
109BCOR_27268052_Chip-Seq_Bcells_Human1.00807431
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.00447620
111KDM5A_27292631_Chip-Seq_BREAST_Human0.99408137
112BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98707655
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98218918
114UTX_26944678_Chip-Seq_JUKART_Human0.98172373
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97572738
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.90756683
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90432940
118TFEB_21752829_ChIP-Seq_HELA_Human0.89544439
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89515345
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89439808
121NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87798244
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87717904
123E2F4_17652178_ChIP-ChIP_JURKAT_Human0.86552478
124GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85455214
125FOXP1_21924763_ChIP-Seq_HESCs_Human0.84741260
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84414579
127MYC_18940864_ChIP-ChIP_HL60_Human0.84401703
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.84399688
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82987260
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80644651
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79762709
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79590759
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79478033
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78318465
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77870054
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77683851
137TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.76527224
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75073443
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.74494938
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73847674
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.72388524
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71837411
143KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71827073
144BCL6_27268052_Chip-Seq_Bcells_Human0.71057928
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70310234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.54619403
2MP0002837_dystrophic_cardiac_calcinosis4.23472011
3MP0005451_abnormal_body_composition3.99848526
4MP0005464_abnormal_platelet_physiology3.96302907
5MP0006036_abnormal_mitochondrial_physio3.60582402
6MP0000749_muscle_degeneration3.34481585
7MP0005058_abnormal_lysosome_morphology3.17268418
8MP0000751_myopathy3.07606755
9MP0003705_abnormal_hypodermis_morpholog2.76329124
10MP0002736_abnormal_nociception_after2.76143655
11MP0001968_abnormal_touch/_nociception2.70146262
12MP0004215_abnormal_myocardial_fiber2.68753836
13MP0002877_abnormal_melanocyte_morpholog2.64957721
14MP0003111_abnormal_nucleus_morphology2.64033453
15MP0003806_abnormal_nucleotide_metabolis2.60600096
16MP0004147_increased_porphyrin_level2.58726336
17MP0004084_abnormal_cardiac_muscle2.58611914
18MP0006035_abnormal_mitochondrial_morpho2.56930930
19MP0004036_abnormal_muscle_relaxation2.48533152
20MP0003656_abnormal_erythrocyte_physiolo2.45711745
21MP0003880_abnormal_central_pattern2.44726648
22MP0004185_abnormal_adipocyte_glucose2.31895737
23MP0009379_abnormal_foot_pigmentation2.23796009
24MP0004145_abnormal_muscle_electrophysio2.23010950
25MP0003566_abnormal_cell_adhesion2.21326080
26MP0010094_abnormal_chromosome_stability2.09361137
27MP0008932_abnormal_embryonic_tissue2.06321517
28MP0003693_abnormal_embryo_hatching2.06243056
29MP0005330_cardiomyopathy2.03098571
30MP0001661_extended_life_span2.01552410
31MP0002876_abnormal_thyroid_physiology2.00613676
32MP0003077_abnormal_cell_cycle1.96831880
33MP0005501_abnormal_skin_physiology1.96772745
34MP0009333_abnormal_splenocyte_physiolog1.89778596
35MP0002735_abnormal_chemical_nociception1.83453781
36MP0001529_abnormal_vocalization1.81566645
37MP0003186_abnormal_redox_activity1.75358073
38MP0004859_abnormal_synaptic_plasticity1.74455930
39MP0001730_embryonic_growth_arrest1.68332298
40MP0001849_ear_inflammation1.67605366
41MP0004043_abnormal_pH_regulation1.65566448
42MP0004957_abnormal_blastocyst_morpholog1.65465458
43MP0000747_muscle_weakness1.63568747
44MP0003879_abnormal_hair_cell1.60918744
45MP0002734_abnormal_mechanical_nocicepti1.60777398
46MP0002822_catalepsy1.58537020
47MP0000343_altered_response_to1.57653106
48MP0002269_muscular_atrophy1.56661221
49MP0003453_abnormal_keratinocyte_physiol1.46687339
50MP0003195_calcinosis1.43799352
51MP0001984_abnormal_olfaction1.43177858
52MP0002909_abnormal_adrenal_gland1.43163226
53MP0003635_abnormal_synaptic_transmissio1.41579847
54MP0000013_abnormal_adipose_tissue1.41218946
55MP0005084_abnormal_gallbladder_morpholo1.40188923
56MP0005666_abnormal_adipose_tissue1.40005038
57MP0000350_abnormal_cell_proliferation1.39408858
58MP0004270_analgesia1.38913914
59MP0005620_abnormal_muscle_contractility1.38002831
60MP0000678_abnormal_parathyroid_gland1.37837575
61MP0002796_impaired_skin_barrier1.34783168
62MP0002972_abnormal_cardiac_muscle1.34735670
63MP0001764_abnormal_homeostasis1.34210514
64MP0000750_abnormal_muscle_regeneration1.34123430
65MP0002272_abnormal_nervous_system1.33898692
66MP0002106_abnormal_muscle_physiology1.33360144
67MP0000858_altered_metastatic_potential1.32245590
68MP0004510_myositis1.30976717
69MP0000313_abnormal_cell_death1.30756388
70MP0010234_abnormal_vibrissa_follicle1.29411105
71MP0006276_abnormal_autonomic_nervous1.29283501
72MP0001664_abnormal_digestion1.29264413
73MP0000490_abnormal_crypts_of1.28188940
74MP0004130_abnormal_muscle_cell1.27916355
75MP0009840_abnormal_foam_cell1.26211259
76MP0001905_abnormal_dopamine_level1.26081394
77MP0002064_seizures1.25874499
78MP0003191_abnormal_cellular_cholesterol1.25484360
79MP0001346_abnormal_lacrimal_gland1.23381159
80MP0002080_prenatal_lethality1.22951876
81MP0008004_abnormal_stomach_pH1.22542535
82MP0003137_abnormal_impulse_conducting1.22072349
83MP0008007_abnormal_cellular_replicative1.22001332
84MP0004087_abnormal_muscle_fiber1.20687454
85MP0000759_abnormal_skeletal_muscle1.20095761
86MP0002132_abnormal_respiratory_system1.18495673
87MP0009745_abnormal_behavioral_response1.18434054
88MP0005636_abnormal_mineral_homeostasis1.17056657
89MP0000537_abnormal_urethra_morphology1.14895448
90MP0009046_muscle_twitch1.14806015
91MP0001970_abnormal_pain_threshold1.13428268
92MP0005266_abnormal_metabolism1.13143222
93MP0005646_abnormal_pituitary_gland1.13016945
94MP0003786_premature_aging1.11707656
95MP0004142_abnormal_muscle_tone1.10874924
96MP0000733_abnormal_muscle_development1.10045424
97MP0008775_abnormal_heart_ventricle1.08790544
98MP0005083_abnormal_biliary_tract1.08785315
99MP0010630_abnormal_cardiac_muscle1.08675596
100MP0000358_abnormal_cell_content/1.08263984
101MP0009278_abnormal_bone_marrow1.07757345
102MP0005369_muscle_phenotype1.07258907
103MP0009697_abnormal_copulation1.06964890
104MP0003183_abnormal_peptide_metabolism1.06505309
105MP0005623_abnormal_meninges_morphology1.03655903
106MP0005385_cardiovascular_system_phenoty1.03634728
107MP0001544_abnormal_cardiovascular_syste1.03634728
108MP0001697_abnormal_embryo_size1.03282367
109MP0003221_abnormal_cardiomyocyte_apopto1.01926348
110MP0008872_abnormal_physiological_respon1.01715086
111MP0008874_decreased_physiological_sensi1.00903309
112MP0005621_abnormal_cell_physiology1.00668974
113MP0000003_abnormal_adipose_tissue1.00414075
114MP0004085_abnormal_heartbeat1.00046400
115MP0005584_abnormal_enzyme/coenzyme_acti0.99642743
116MP0005375_adipose_tissue_phenotype0.99429919
117MP0002063_abnormal_learning/memory/cond0.99270319
118MP0010030_abnormal_orbit_morphology0.98719109
119MP0002163_abnormal_gland_morphology0.98445945
120MP0009672_abnormal_birth_weight0.96861611
121MP0005384_cellular_phenotype0.94779370
122MP0002067_abnormal_sensory_capabilities0.94205306
123MP0000465_gastrointestinal_hemorrhage0.93727758
124MP0002572_abnormal_emotion/affect_behav0.93654026
125MP0005386_behavior/neurological_phenoty0.93573065
126MP0004924_abnormal_behavior0.93573065
127MP0010386_abnormal_urinary_bladder0.93283424
128MP0005397_hematopoietic_system_phenotyp0.91921529
129MP0001545_abnormal_hematopoietic_system0.91921529
130MP0002249_abnormal_larynx_morphology0.91850045
131MP0001727_abnormal_embryo_implantation0.91794248
132MP0005076_abnormal_cell_differentiation0.90645005
133MP0005332_abnormal_amino_acid0.90183395
134MP0002638_abnormal_pupillary_reflex0.89980224
135MP0005380_embryogenesis_phenotype0.89422918
136MP0001672_abnormal_embryogenesis/_devel0.89422918
137MP0003123_paternal_imprinting0.88889803
138MP0008058_abnormal_DNA_repair0.88802005
139MP0008260_abnormal_autophagy0.88435917
140MP0008569_lethality_at_weaning0.87535866
141MP0004484_altered_response_of0.87225130
142MP0002733_abnormal_thermal_nociception0.86977729
143MP0002019_abnormal_tumor_incidence0.85094710
144MP0003984_embryonic_growth_retardation0.84488552
145MP0000230_abnormal_systemic_arterial0.84329954
146MP0009780_abnormal_chondrocyte_physiolo0.84270725
147MP0005535_abnormal_body_temperature0.83428590
148MP0005165_increased_susceptibility_to0.82150061
149MP0002086_abnormal_extraembryonic_tissu0.82136711
150MP0000703_abnormal_thymus_morphology0.81768543
151MP0005319_abnormal_enzyme/_coenzyme0.79418593
152MP0006054_spinal_hemorrhage0.78713592
153MP0004947_skin_inflammation0.78199656
154MP0002088_abnormal_embryonic_growth/wei0.75057609
155MP0002398_abnormal_bone_marrow0.74103536
156MP0009931_abnormal_skin_appearance0.73903970
157MP0005220_abnormal_exocrine_pancreas0.73550488
158MP0005376_homeostasis/metabolism_phenot0.72572193
159MP0000467_abnormal_esophagus_morphology0.72031651
160MP0000681_abnormal_thyroid_gland0.71390345
161MP0003763_abnormal_thymus_physiology0.70234269
162MP0004233_abnormal_muscle_weight0.70005695
163MP0001663_abnormal_digestive_system0.69321185
164MP0006138_congestive_heart_failure0.69055091
165MP0002078_abnormal_glucose_homeostasis0.68673955
166MP0002332_abnormal_exercise_endurance0.65326432
167MP0000372_irregular_coat_pigmentation0.65222227

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.62262476
2Abnormal mitochondria in muscle tissue (HP:0008316)5.59015276
3Hepatocellular necrosis (HP:0001404)5.46810879
4Mitochondrial inheritance (HP:0001427)5.36440729
5Hepatic necrosis (HP:0002605)5.34243159
6Increased CSF lactate (HP:0002490)5.04504292
7Acute encephalopathy (HP:0006846)4.81667083
8Petechiae (HP:0000967)4.63515709
9Progressive macrocephaly (HP:0004481)4.42291806
10Increased serum pyruvate (HP:0003542)4.33743837
11Abnormality of glycolysis (HP:0004366)4.33743837
12Increased mean platelet volume (HP:0011877)3.95952889
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.91131576
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.91131576
15Lactic acidosis (HP:0003128)3.90628464
16Increased intramyocellular lipid droplets (HP:0012240)3.89033639
17Prolonged bleeding time (HP:0003010)3.86611691
18Increased serum lactate (HP:0002151)3.83555399
19Increased hepatocellular lipid droplets (HP:0006565)3.78523697
20Neuroendocrine neoplasm (HP:0100634)3.76799296
21Distal lower limb amyotrophy (HP:0008944)3.76691208
22Menorrhagia (HP:0000132)3.73977973
23Abnormal platelet volume (HP:0011876)3.73454684
24Lipid accumulation in hepatocytes (HP:0006561)3.71197055
25Pheochromocytoma (HP:0002666)3.68543809
26Purpura (HP:0000979)3.66621669
27Exercise intolerance (HP:0003546)3.65335688
28Increased muscle lipid content (HP:0009058)3.63345156
29Abnormal gallbladder physiology (HP:0012438)3.58107058
30Cholecystitis (HP:0001082)3.58107058
31Increased connective tissue (HP:0009025)3.56552601
32Centrally nucleated skeletal muscle fibers (HP:0003687)3.47382395
33Nemaline bodies (HP:0003798)3.44677363
34Respiratory failure (HP:0002878)3.42442645
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.38547596
36Distal lower limb muscle weakness (HP:0009053)3.37501782
37Cerebral edema (HP:0002181)3.37463643
38Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.36355036
39Myopathic facies (HP:0002058)3.31098142
40Cerebral hypomyelination (HP:0006808)3.20475889
41Truncus arteriosus (HP:0001660)3.16053062
423-Methylglutaconic aciduria (HP:0003535)3.15415208
43Renal Fanconi syndrome (HP:0001994)3.08694690
44CNS demyelination (HP:0007305)3.05064634
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.03778492
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99465958
47Abnormality of alanine metabolism (HP:0010916)2.99465958
48Hyperalaninemia (HP:0003348)2.99465958
49Abnormal platelet function (HP:0011869)2.98733657
50Impaired platelet aggregation (HP:0003540)2.98733657
51Palpitations (HP:0001962)2.96266297
52Hyperthyroidism (HP:0000836)2.84818735
53Emotional lability (HP:0000712)2.84137744
54Ragged-red muscle fibers (HP:0003200)2.77433569
55Reticulocytosis (HP:0001923)2.76581294
56Abnormality of the Achilles tendon (HP:0005109)2.75752385
57Generalized aminoaciduria (HP:0002909)2.75212849
58Abnormality of skeletal muscle fiber size (HP:0012084)2.73130595
59Achilles tendon contracture (HP:0001771)2.69602688
60Myoglobinuria (HP:0002913)2.66517512
61Lower limb amyotrophy (HP:0007210)2.64006915
62Respiratory difficulties (HP:0002880)2.60542614
63Vertebral compression fractures (HP:0002953)2.56830806
64Paralysis (HP:0003470)2.55563714
65Exercise-induced muscle cramps (HP:0003710)2.54950944
66Exercise-induced myalgia (HP:0003738)2.53470640
67Optic disc pallor (HP:0000543)2.52623176
68Epistaxis (HP:0000421)2.49553983
69Leukodystrophy (HP:0002415)2.47266772
70Exertional dyspnea (HP:0002875)2.46678097
71Abnormal number of erythroid precursors (HP:0012131)2.45327467
72Lethargy (HP:0001254)2.45144962
73Sudden death (HP:0001699)2.44062644
74Unsteady gait (HP:0002317)2.43573935
75Progressive muscle weakness (HP:0003323)2.43438029
76Aplastic anemia (HP:0001915)2.39458746
77Dicarboxylic aciduria (HP:0003215)2.39281091
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39281091
79Myotonia (HP:0002486)2.35571510
80Poor suck (HP:0002033)2.34029925
81Abnormality of fatty-acid metabolism (HP:0004359)2.32802667
82Abnormality of cells of the erythroid lineage (HP:0012130)2.31706317
83Type I transferrin isoform profile (HP:0003642)2.31600330
84Increased variability in muscle fiber diameter (HP:0003557)2.31190526
85Neoplasm of the adrenal gland (HP:0100631)2.25702811
86Rhabdomyolysis (HP:0003201)2.24063883
87Type 1 muscle fiber predominance (HP:0003803)2.23738223
88Abnormal large intestine physiology (HP:0012700)2.22688935
89Hypokinesia (HP:0002375)2.21583646
90Abnormality of the tricuspid valve (HP:0001702)2.20987878
91Reduced subcutaneous adipose tissue (HP:0003758)2.20770082
92Methylmalonic aciduria (HP:0012120)2.20621341
93Microvesicular hepatic steatosis (HP:0001414)2.20554873
94Abnormality of the umbilical cord (HP:0010881)2.20254395
95Abnormality of reticulocytes (HP:0004312)2.19906636
96Calf muscle hypertrophy (HP:0008981)2.17947379
97Neoplasm of the peripheral nervous system (HP:0100007)2.17397438
98EMG: myopathic abnormalities (HP:0003458)2.17117869
99Progressive external ophthalmoplegia (HP:0000590)2.16769359
100Bulbar palsy (HP:0001283)2.11767436
101Irregular epiphyses (HP:0010582)2.10281576
102Muscle hypertrophy of the lower extremities (HP:0008968)2.09089156
103Hypertensive crisis (HP:0100735)2.08458597
104Conjunctival hamartoma (HP:0100780)2.08023585
105Trismus (HP:0000211)2.07601562
106Gout (HP:0001997)2.06161799
107Abnormality of urine glucose concentration (HP:0011016)2.05722291
108Glycosuria (HP:0003076)2.05722291
109Back pain (HP:0003418)2.03635991
110Hepatosplenomegaly (HP:0001433)2.02420526
111Septate vagina (HP:0001153)2.02193810
112Epileptic encephalopathy (HP:0200134)2.01645214
113Upper limb muscle weakness (HP:0003484)2.01622088
114Gliosis (HP:0002171)2.01154145
115Hypoplasia of the uterus (HP:0000013)2.00536600
116Bowel incontinence (HP:0002607)1.99756343
117Muscle stiffness (HP:0003552)1.98920513
118Aplasia/hypoplasia of the uterus (HP:0008684)1.97367748
119Neck muscle weakness (HP:0000467)1.95666984
120Oral leukoplakia (HP:0002745)1.94771243
121Abnormality of the distal phalanges of the toes (HP:0010182)1.94766407
122Difficulty climbing stairs (HP:0003551)1.93116984
123Reduced antithrombin III activity (HP:0001976)1.91746703
124Abnormality of lateral ventricle (HP:0030047)1.91568378
125Cholelithiasis (HP:0001081)1.91494831
126Fatigue (HP:0012378)1.91477799
127Spinal rigidity (HP:0003306)1.91180203
128Hyperventilation (HP:0002883)1.90251646
129Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88292219
130X-linked dominant inheritance (HP:0001423)1.87216676
131Hyperacusis (HP:0010780)1.86866174
132Broad distal phalanx of finger (HP:0009836)1.86509913
133Delusions (HP:0000746)1.85606074
134CNS hypomyelination (HP:0003429)1.84727648
135Abnormal protein N-linked glycosylation (HP:0012347)1.84726738
136Abnormal protein glycosylation (HP:0012346)1.84726738
137Abnormal glycosylation (HP:0012345)1.84726738
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84726738
139Neoplasm of head and neck (HP:0012288)1.83640258
140Esophageal neoplasm (HP:0100751)1.83640258
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.83474587
142Vomiting (HP:0002013)1.83232375
143Increased serum ferritin (HP:0003281)1.83002683
144Focal motor seizures (HP:0011153)1.82039065
145Abnormal gallbladder morphology (HP:0012437)1.81998368
146Abnormality of renal resorption (HP:0011038)1.80337293
147Abnormality of the gallbladder (HP:0005264)1.79870673
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78720629
149Polycythemia (HP:0001901)1.78548882
150Calcaneovalgus deformity (HP:0001848)1.77772978
151Microretrognathia (HP:0000308)1.77622895
152Generalized amyotrophy (HP:0003700)1.75708712
153Hypoparathyroidism (HP:0000829)1.74949101
154Hyporeflexia of lower limbs (HP:0002600)1.74502974
155Postnatal microcephaly (HP:0005484)1.74489705
156Upper limb amyotrophy (HP:0009129)1.73667855
157Distal upper limb amyotrophy (HP:0007149)1.73667855
158Mildly elevated creatine phosphokinase (HP:0008180)1.73543749
159Oligomenorrhea (HP:0000876)1.73120753
160Foot dorsiflexor weakness (HP:0009027)1.72583034
161Insidious onset (HP:0003587)1.71883248
162Termporal pattern (HP:0011008)1.71883248
163Testicular atrophy (HP:0000029)1.71022987
164Hyperphosphaturia (HP:0003109)1.70832071
165Poikilocytosis (HP:0004447)1.70535076
166Tinnitus (HP:0000360)1.70258425
167Abnormality of the fetal cardiovascular system (HP:0010948)1.69928261
168Abnormal umbilical cord blood vessels (HP:0011403)1.69928261
169Single umbilical artery (HP:0001195)1.69928261
170Nausea (HP:0002018)1.69327888
171Abnormality of the calcaneus (HP:0008364)1.68934978
172Poor head control (HP:0002421)1.68223949
173Hypoplasia of the pons (HP:0012110)1.68183714
174Stridor (HP:0010307)1.68090008
175Muscle fiber inclusion bodies (HP:0100299)1.68021889
176Seborrheic dermatitis (HP:0001051)1.67611064
177Orthostatic hypotension (HP:0001278)1.66644986
178Rough bone trabeculation (HP:0100670)1.63996381
179Breast hypoplasia (HP:0003187)1.63258085
180Male infertility (HP:0003251)1.62858527
181Ankyloglossia (HP:0010296)1.61909748
182Acanthocytosis (HP:0001927)1.61581984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.88798223
2TRIB33.74061852
3EIF2AK13.49242549
4BUB13.14907386
5CCNB13.14760467
6SMG12.97827502
7MAP3K122.86330153
8CASK2.84600398
9BCKDK2.50602229
10NME22.38275677
11NEK12.32147698
12MYLK2.31509802
13NME12.26383136
14LMTK22.25432200
15CDK192.19323268
16EEF2K2.17903099
17DAPK12.11913601
18PIM21.95177611
19BMX1.86443591
20TSSK61.86432280
21PRPF4B1.79920130
22MAP2K71.79764309
23PDK31.78225801
24PDK41.78225801
25MUSK1.76288268
26ICK1.73775321
27SIK11.72980132
28VRK21.71016400
29SIK31.65786897
30WEE11.62558831
31ARAF1.61049538
32EIF2AK31.60512660
33OBSCN1.57987452
34EPHA21.51923542
35RIPK41.50704127
36FLT31.46758397
37VRK11.45754447
38MST1R1.45368226
39BRAF1.44917433
40BRSK11.44095275
41KSR21.43295790
42CAMKK21.42544963
43AKT31.42367460
44DAPK21.36409909
45SCYL21.34902201
46PHKG11.31584078
47PHKG21.31584078
48PAK41.25583637
49TAOK21.23288037
50LIMK11.22866537
51PLK21.17341800
52PINK11.14523027
53MAP3K81.13004466
54TESK11.11206322
55IRAK21.10811999
56PKN21.10448696
57BRSK21.08977445
58MINK11.08324819
59MAP3K111.08037821
60TLK11.06375182
61ILK0.99154902
62PAK10.97011085
63TESK20.94365516
64DAPK30.93664297
65MAP2K60.93312251
66NTRK30.91836344
67PDK20.90646023
68PRKD30.88273563
69CDK80.85654847
70CDK70.84499326
71MAPK110.82237555
72PLK40.81494308
73RPS6KB20.80701336
74MAPKAPK30.79149708
75PDPK10.78318868
76TAOK10.76625431
77LRRK20.76301366
78MAP3K10.74325338
79PRKG20.73545576
80CDC70.73179998
81STK40.72892556
82ACVR1B0.72648469
83TNIK0.72078078
84GRK50.71069204
85ABL20.70615267
86AKT20.68206402
87TTK0.67569355
88STK240.63463376
89RAF10.63421799
90KDR0.60777314
91MAP3K100.58897044
92SRPK10.58820903
93CHEK20.58312631
94AURKA0.56896759
95GRK70.52368937
96MAP2K40.52037893
97CAMK2D0.50747377
98PBK0.47757473
99GRK60.47735281
100IRAK30.46840515
101CLK10.46740343
102OXSR10.46593410
103CAMK10.44757065
104PRKCG0.44567963
105CDK40.44405825
106EPHA40.44113507
107MST40.44104943
108CAMK2B0.43850493
109TTN0.43749621
110MAP3K40.43183243
111CDK180.43150001
112BCR0.43126205
113CAMK2G0.41929539
114UHMK10.41829926
115AURKB0.41677024
116PLK30.41574608
117CDK140.40483732
118MAP3K50.40050095
119MTOR0.39993682
120CDK120.38752842
121MET0.37696749
122EPHB10.36865891
123ZAP700.36736153
124MAP2K20.36473580
125ADRBK10.35987429
126MAP2K30.35851399
127BTK0.35712575
128CSNK2A10.35146386
129PRKCI0.33804883
130PTK20.33596161
131CAMK2A0.32621659
132CDK150.31709885
133CDK11A0.31299254
134MAP3K130.31063156
135MAP3K20.30668599
136PRKACA0.29910532
137NEK90.28072428
138PLK10.28039644
139KSR10.27333305
140DYRK20.27303668
141MAP2K10.26553366
142ERN10.25562223
143CSNK2A20.24116806
144MAPK120.22981347
145IRAK40.22752719
146MAP3K30.22393141

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.59419266
2Oxidative phosphorylation_Homo sapiens_hsa001904.59047096
3Proteasome_Homo sapiens_hsa030504.17503837
4Parkinsons disease_Homo sapiens_hsa050124.09285598
5Ribosome_Homo sapiens_hsa030103.24384962
6Protein export_Homo sapiens_hsa030602.79612003
7Alzheimers disease_Homo sapiens_hsa050102.77744404
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.77332710
9Huntingtons disease_Homo sapiens_hsa050162.64326634
10RNA polymerase_Homo sapiens_hsa030202.54085970
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.25579636
12DNA replication_Homo sapiens_hsa030302.16812859
13Cardiac muscle contraction_Homo sapiens_hsa042602.11289182
14Carbon metabolism_Homo sapiens_hsa012001.91784630
15Synaptic vesicle cycle_Homo sapiens_hsa047211.89243587
16Vibrio cholerae infection_Homo sapiens_hsa051101.85031118
17Collecting duct acid secretion_Homo sapiens_hsa049661.84947354
18Pyrimidine metabolism_Homo sapiens_hsa002401.83821276
19Pyruvate metabolism_Homo sapiens_hsa006201.69621655
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.68678470
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60242642
22Non-small cell lung cancer_Homo sapiens_hsa052231.59781485
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.54581397
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52400571
25Bladder cancer_Homo sapiens_hsa052191.50561698
26Chronic myeloid leukemia_Homo sapiens_hsa052201.45658358
27Mismatch repair_Homo sapiens_hsa034301.44221979
28Biosynthesis of amino acids_Homo sapiens_hsa012301.43653861
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41096547
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38869961
31Propanoate metabolism_Homo sapiens_hsa006401.37305351
32Pancreatic cancer_Homo sapiens_hsa052121.35993812
33Fructose and mannose metabolism_Homo sapiens_hsa000511.35296922
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33554232
35Folate biosynthesis_Homo sapiens_hsa007901.31873181
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31342132
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.30154835
38Thyroid cancer_Homo sapiens_hsa052161.27038827
39Purine metabolism_Homo sapiens_hsa002301.26613568
40Acute myeloid leukemia_Homo sapiens_hsa052211.21790146
41Nucleotide excision repair_Homo sapiens_hsa034201.21430685
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20137707
43Platelet activation_Homo sapiens_hsa046111.20017053
44Shigellosis_Homo sapiens_hsa051311.19656416
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18576255
46Base excision repair_Homo sapiens_hsa034101.17980109
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14861771
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10120983
49Pentose phosphate pathway_Homo sapiens_hsa000301.09364110
50Spliceosome_Homo sapiens_hsa030401.09342097
51Glioma_Homo sapiens_hsa052141.06831950
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99726051
53Fatty acid elongation_Homo sapiens_hsa000620.99144152
54Other glycan degradation_Homo sapiens_hsa005110.98988826
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97743422
56VEGF signaling pathway_Homo sapiens_hsa043700.97296557
57Alcoholism_Homo sapiens_hsa050340.95426401
58Endometrial cancer_Homo sapiens_hsa052130.92694203
59Olfactory transduction_Homo sapiens_hsa047400.91663831
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.90276614
61Galactose metabolism_Homo sapiens_hsa000520.89351518
62Sulfur metabolism_Homo sapiens_hsa009200.89104687
63Regulation of autophagy_Homo sapiens_hsa041400.89049481
64Viral carcinogenesis_Homo sapiens_hsa052030.88375844
65Apoptosis_Homo sapiens_hsa042100.86382789
66Metabolic pathways_Homo sapiens_hsa011000.85179147
67Endocytosis_Homo sapiens_hsa041440.82649802
68Vitamin B6 metabolism_Homo sapiens_hsa007500.81321474
69Small cell lung cancer_Homo sapiens_hsa052220.77002717
70Fatty acid degradation_Homo sapiens_hsa000710.76267630
71RNA transport_Homo sapiens_hsa030130.74274325
72Renal cell carcinoma_Homo sapiens_hsa052110.72309801
73Homologous recombination_Homo sapiens_hsa034400.70731343
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68430549
75N-Glycan biosynthesis_Homo sapiens_hsa005100.65495307
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64995075
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63494216
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62124754
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61637554
80AMPK signaling pathway_Homo sapiens_hsa041520.61553096
81Nicotine addiction_Homo sapiens_hsa050330.60632711
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60379433
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.59596416
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59305610
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57769416
86Fatty acid metabolism_Homo sapiens_hsa012120.56934539
87Prion diseases_Homo sapiens_hsa050200.55865933
88ErbB signaling pathway_Homo sapiens_hsa040120.55794199
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.53360664
90HIF-1 signaling pathway_Homo sapiens_hsa040660.53081790
91B cell receptor signaling pathway_Homo sapiens_hsa046620.52591930
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52462294
93Systemic lupus erythematosus_Homo sapiens_hsa053220.51394696
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.51026432
95Butanoate metabolism_Homo sapiens_hsa006500.50564488
96Gap junction_Homo sapiens_hsa045400.50235119
97Sulfur relay system_Homo sapiens_hsa041220.48173022
98Focal adhesion_Homo sapiens_hsa045100.45418663
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44616369
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44546394
101Glutathione metabolism_Homo sapiens_hsa004800.44435926
102mTOR signaling pathway_Homo sapiens_hsa041500.44331746
103Pancreatic secretion_Homo sapiens_hsa049720.43772831
104Hepatitis B_Homo sapiens_hsa051610.42707025
105Peroxisome_Homo sapiens_hsa041460.41986044
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.41780122
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41310286
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40831599
109Lysosome_Homo sapiens_hsa041420.40784297
110Salmonella infection_Homo sapiens_hsa051320.40272390
111Phenylalanine metabolism_Homo sapiens_hsa003600.40245224
112Arginine and proline metabolism_Homo sapiens_hsa003300.39845751
113Notch signaling pathway_Homo sapiens_hsa043300.39837988
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39271951
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38539789
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38327844
117Circadian entrainment_Homo sapiens_hsa047130.36482197
118RNA degradation_Homo sapiens_hsa030180.35198790
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34622896
120Insulin secretion_Homo sapiens_hsa049110.33680840
121GABAergic synapse_Homo sapiens_hsa047270.33313749
122Legionellosis_Homo sapiens_hsa051340.31758019
123Amphetamine addiction_Homo sapiens_hsa050310.31220021
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30885159
125Long-term potentiation_Homo sapiens_hsa047200.29649373
126Calcium signaling pathway_Homo sapiens_hsa040200.28563739
127beta-Alanine metabolism_Homo sapiens_hsa004100.27661751
128Phagosome_Homo sapiens_hsa041450.27426563
129Dopaminergic synapse_Homo sapiens_hsa047280.26514406
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26118430
131Arachidonic acid metabolism_Homo sapiens_hsa005900.25555158
132Oocyte meiosis_Homo sapiens_hsa041140.25491700
133Epstein-Barr virus infection_Homo sapiens_hsa051690.24177981
134Morphine addiction_Homo sapiens_hsa050320.23654669
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22747201
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22700687
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.22276207
138Dilated cardiomyopathy_Homo sapiens_hsa054140.21128688
139Insulin signaling pathway_Homo sapiens_hsa049100.19051134
140Renin-angiotensin system_Homo sapiens_hsa046140.18036581
141Basal transcription factors_Homo sapiens_hsa030220.17153875
142Starch and sucrose metabolism_Homo sapiens_hsa005000.17003099
143Cell cycle_Homo sapiens_hsa041100.15530080
144One carbon pool by folate_Homo sapiens_hsa006700.15404339
145Fat digestion and absorption_Homo sapiens_hsa049750.13812342
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13492902

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