UBL5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1estrogen biosynthetic process (GO:0006703)5.00315867
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.82308196
3protein neddylation (GO:0045116)4.72859777
4positive regulation of growth hormone secretion (GO:0060124)4.71001031
5opioid receptor signaling pathway (GO:0038003)4.54574092
6adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.54492175
7transmission of nerve impulse (GO:0019226)4.44734183
8behavioral response to ethanol (GO:0048149)4.44444680
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.34405404
10behavioral response to nicotine (GO:0035095)4.33400795
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.30632117
12ATP synthesis coupled proton transport (GO:0015986)4.21433298
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21433298
14head development (GO:0060322)4.14800538
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.13716178
16negative regulation of organelle assembly (GO:1902116)4.10913538
17myoblast migration (GO:0051451)4.07399475
18forebrain neuron differentiation (GO:0021879)4.03451236
19growth hormone secretion (GO:0030252)4.02321461
20axoneme assembly (GO:0035082)4.01356838
21DNA deamination (GO:0045006)3.97316839
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93905027
23ribosomal small subunit assembly (GO:0000028)3.92610285
24actin nucleation (GO:0045010)3.92074144
25cytidine metabolic process (GO:0046087)3.86590640
26cytidine catabolic process (GO:0006216)3.86590640
27cytidine deamination (GO:0009972)3.86590640
28pyrimidine nucleotide catabolic process (GO:0006244)3.75523402
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58931692
30pyrimidine ribonucleoside catabolic process (GO:0046133)3.54929695
31negative regulation of cytosolic calcium ion concentration (GO:0051481)3.54468360
32ribosomal small subunit biogenesis (GO:0042274)3.51630493
33DNA demethylation (GO:0080111)3.44274874
34spinal cord association neuron differentiation (GO:0021527)3.42893305
35deoxyribonucleotide catabolic process (GO:0009264)3.41273027
36negative regulation of mast cell activation (GO:0033004)3.40524788
37pyrimidine nucleobase catabolic process (GO:0006208)3.40396941
38respiratory electron transport chain (GO:0022904)3.37588196
39detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.33521090
40purine deoxyribonucleotide catabolic process (GO:0009155)3.32055788
41electron transport chain (GO:0022900)3.31848357
42oxidative demethylation (GO:0070989)3.23995136
43positive regulation of cAMP-mediated signaling (GO:0043950)3.22283508
44ncRNA 3-end processing (GO:0043628)3.19388592
45adaptation of signaling pathway (GO:0023058)3.16282390
46somite development (GO:0061053)3.12963208
47neurofilament cytoskeleton organization (GO:0060052)3.12185209
48gonadal mesoderm development (GO:0007506)3.07746132
49pyrimidine nucleoside catabolic process (GO:0046135)3.05526330
50deoxyribose phosphate catabolic process (GO:0046386)3.04351769
51negative regulation of interleukin-1 beta production (GO:0032691)3.03266953
52regulation of G0 to G1 transition (GO:0070316)2.98402075
53blood vessel maturation (GO:0001955)2.97233587
54establishment of mitochondrion localization (GO:0051654)2.97077443
55maturation of SSU-rRNA (GO:0030490)2.94271935
56sequestering of actin monomers (GO:0042989)2.93848796
57detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.93727360
58negative regulation of cAMP-mediated signaling (GO:0043951)2.93113781
59dendritic spine morphogenesis (GO:0060997)2.92436825
60DNA dealkylation (GO:0035510)2.89803470
61regulation of action potential (GO:0098900)2.88993947
62regulation of synapse structural plasticity (GO:0051823)2.85950187
63ubiquinone biosynthetic process (GO:0006744)2.85065953
64olfactory bulb development (GO:0021772)2.83959043
65synaptic transmission, cholinergic (GO:0007271)2.77342156
66regulation of growth hormone secretion (GO:0060123)2.74619351
67adult feeding behavior (GO:0008343)2.73091004
68GPI anchor metabolic process (GO:0006505)2.72918831
69mitochondrion transport along microtubule (GO:0047497)2.72474978
70establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72474978
71nucleobase catabolic process (GO:0046113)2.72162870
72ubiquinone metabolic process (GO:0006743)2.72095228
73positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.71761728
74viral transcription (GO:0019083)2.71672918
75negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69551932
76pyrimidine-containing compound catabolic process (GO:0072529)2.68787409
77translational termination (GO:0006415)2.67030712
78cellular ketone body metabolic process (GO:0046950)2.66612421
79forebrain morphogenesis (GO:0048853)2.65120910
80negative regulation of telomere maintenance (GO:0032205)2.65072573
81layer formation in cerebral cortex (GO:0021819)2.64694144
82negative regulation of nitric-oxide synthase activity (GO:0051001)2.62794865
83DNA damage response, detection of DNA damage (GO:0042769)2.62295961
84monocyte chemotaxis (GO:0002548)2.59829297
85negative regulation of interleukin-1 production (GO:0032692)2.58741031
86protein complex biogenesis (GO:0070271)2.58521753
87establishment of protein localization to mitochondrial membrane (GO:0090151)2.58203083
88brain morphogenesis (GO:0048854)2.57319295
89glomerulus development (GO:0032835)2.56483929
90sulfate transport (GO:0008272)2.55984613
91proteasome assembly (GO:0043248)2.52643714
92purine deoxyribonucleotide metabolic process (GO:0009151)2.52147220
93nucleoside diphosphate catabolic process (GO:0009134)2.52141712
94cell proliferation in forebrain (GO:0021846)2.48645906
95regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.48630130
96regulation of response to food (GO:0032095)2.47322156
97hydrogen ion transmembrane transport (GO:1902600)2.45173600
98thalamus development (GO:0021794)2.43893114
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.42400073
100cerebellar Purkinje cell differentiation (GO:0021702)2.41363643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44665537
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.31053362
3ZNF274_21170338_ChIP-Seq_K562_Hela2.73313613
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63286339
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56159201
6VDR_22108803_ChIP-Seq_LS180_Human2.39330664
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39036141
8IRF1_19129219_ChIP-ChIP_H3396_Human2.24630207
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19048730
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04721837
11ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99288042
12REST_21632747_ChIP-Seq_MESCs_Mouse1.97618747
13CBX2_27304074_Chip-Seq_ESCs_Mouse1.91721415
14GATA1_26923725_Chip-Seq_HPCs_Mouse1.90902632
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88909056
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86269891
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83858812
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73555953
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.71597811
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65982496
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.63660852
22GBX2_23144817_ChIP-Seq_PC3_Human1.62124449
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60560522
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57069454
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.57033000
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.56732460
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55941111
28IGF1R_20145208_ChIP-Seq_DFB_Human1.52832054
29MYC_18940864_ChIP-ChIP_HL60_Human1.51518111
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.50977554
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49670055
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49089453
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48116483
34GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44868266
35RNF2_27304074_Chip-Seq_NSC_Mouse1.44780228
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44716269
37TP53_22573176_ChIP-Seq_HFKS_Human1.41105633
38P300_19829295_ChIP-Seq_ESCs_Human1.38722091
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37149217
40ER_23166858_ChIP-Seq_MCF-7_Human1.36664171
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36591438
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.36041756
43CBP_20019798_ChIP-Seq_JUKART_Human1.29729009
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29729009
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.29419073
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28914354
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.26854192
48EWS_26573619_Chip-Seq_HEK293_Human1.26725231
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.26279782
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24989917
51TAF2_19829295_ChIP-Seq_ESCs_Human1.24171132
52NCOR_22424771_ChIP-Seq_293T_Human1.23621555
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22254287
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22100257
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21998308
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21733912
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21347495
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20399279
59HTT_18923047_ChIP-ChIP_STHdh_Human1.20076974
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.19830930
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16698980
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16100996
63VDR_23849224_ChIP-Seq_CD4+_Human1.15295502
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13952462
65BCAT_22108803_ChIP-Seq_LS180_Human1.12550296
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11903061
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11355611
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11205565
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.10429334
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09865537
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07205648
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.06288265
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04673157
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.03522082
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03479802
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02677654
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01302243
78ERA_21632823_ChIP-Seq_H3396_Human1.00014651
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99833469
80NANOG_19829295_ChIP-Seq_ESCs_Human0.99066627
81SOX2_19829295_ChIP-Seq_ESCs_Human0.99066627
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98964391
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98828160
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97987543
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97771354
86SMAD4_21799915_ChIP-Seq_A2780_Human0.97764600
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97030752
88RING1B_27294783_Chip-Seq_ESCs_Mouse0.96872572
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96774551
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95983575
91TCF4_22108803_ChIP-Seq_LS180_Human0.95860912
92OCT4_20526341_ChIP-Seq_ESCs_Human0.95508964
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.94269020
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94218733
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93963544
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93415462
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92930167
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.92921149
99NANOG_20526341_ChIP-Seq_ESCs_Human0.92598392
100MYC_19829295_ChIP-Seq_ESCs_Human0.92471811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.37687866
2MP0003122_maternal_imprinting3.87572070
3MP0003787_abnormal_imprinting3.78879683
4MP0004145_abnormal_muscle_electrophysio3.43781087
5MP0006292_abnormal_olfactory_placode3.03252859
6MP0009379_abnormal_foot_pigmentation3.01292451
7MP0006276_abnormal_autonomic_nervous2.64980838
8MP0001968_abnormal_touch/_nociception2.59254384
9MP0003121_genomic_imprinting2.57177174
10MP0008877_abnormal_DNA_methylation2.44061203
11MP0003646_muscle_fatigue2.32994804
12MP0005645_abnormal_hypothalamus_physiol2.32786676
13MP0002733_abnormal_thermal_nociception2.19063310
14MP0003880_abnormal_central_pattern2.16524414
15MP0002138_abnormal_hepatobiliary_system2.16372249
16MP0010386_abnormal_urinary_bladder2.01762226
17MP0004859_abnormal_synaptic_plasticity2.00706911
18MP0005423_abnormal_somatic_nervous2.00267896
19MP0001188_hyperpigmentation1.96414860
20MP0001984_abnormal_olfaction1.83057191
21MP0000778_abnormal_nervous_system1.80115045
22MP0001970_abnormal_pain_threshold1.75906971
23MP0001485_abnormal_pinna_reflex1.69394817
24MP0002063_abnormal_learning/memory/cond1.68334551
25MP0002184_abnormal_innervation1.66641625
26MP0004742_abnormal_vestibular_system1.60707641
27MP0003635_abnormal_synaptic_transmissio1.57180522
28MP0005646_abnormal_pituitary_gland1.55637093
29MP0003011_delayed_dark_adaptation1.53760776
30MP0001905_abnormal_dopamine_level1.53052528
31MP0002736_abnormal_nociception_after1.53035324
32MP0005084_abnormal_gallbladder_morpholo1.51314691
33MP0005551_abnormal_eye_electrophysiolog1.46956984
34MP0004142_abnormal_muscle_tone1.43907094
35MP0004134_abnormal_chest_morphology1.41052024
36MP0009745_abnormal_behavioral_response1.39684396
37MP0000049_abnormal_middle_ear1.34771521
38MP0001486_abnormal_startle_reflex1.34322379
39MP0004885_abnormal_endolymph1.33969447
40MP0000631_abnormal_neuroendocrine_gland1.31436875
41MP0002638_abnormal_pupillary_reflex1.28988413
42MP0005083_abnormal_biliary_tract1.27536441
43MP0002272_abnormal_nervous_system1.27151280
44MP0001764_abnormal_homeostasis1.25121081
45MP0002572_abnormal_emotion/affect_behav1.24182293
46MP0002734_abnormal_mechanical_nocicepti1.24175363
47MP0002095_abnormal_skin_pigmentation1.22263764
48MP0002837_dystrophic_cardiac_calcinosis1.22054733
49MP0008789_abnormal_olfactory_epithelium1.20750703
50MP0002557_abnormal_social/conspecific_i1.18990487
51MP0004133_heterotaxia1.18326498
52MP0003938_abnormal_ear_development1.18035818
53MP0002735_abnormal_chemical_nociception1.17588558
54MP0000955_abnormal_spinal_cord1.16399462
55MP0002752_abnormal_somatic_nervous1.13029795
56MP0008569_lethality_at_weaning1.10644287
57MP0002909_abnormal_adrenal_gland1.08573966
58MP0001293_anophthalmia1.07058175
59MP0005394_taste/olfaction_phenotype1.04682794
60MP0005499_abnormal_olfactory_system1.04682794
61MP0000026_abnormal_inner_ear1.04084633
62MP0005671_abnormal_response_to1.03340444
63MP0008875_abnormal_xenobiotic_pharmacok1.02497194
64MP0002067_abnormal_sensory_capabilities0.98348201
65MP0005253_abnormal_eye_physiology0.97245663
66MP0003137_abnormal_impulse_conducting0.95231790
67MP0002653_abnormal_ependyma_morphology0.95068241
68MP0002882_abnormal_neuron_morphology0.95013072
69MP0002938_white_spotting0.92545283
70MP0008872_abnormal_physiological_respon0.91605520
71MP0003567_abnormal_fetal_cardiomyocyte0.91499048
72MP0006072_abnormal_retinal_apoptosis0.90887224
73MP0001529_abnormal_vocalization0.90015651
74MP0004858_abnormal_nervous_system0.88855573
75MP0004270_analgesia0.88791211
76MP0002234_abnormal_pharynx_morphology0.86170129
77MP0005670_abnormal_white_adipose0.85480092
78MP0005195_abnormal_posterior_eye0.84894066
79MP0006054_spinal_hemorrhage0.80678784
80MP0002160_abnormal_reproductive_system0.80390402
81MP0005266_abnormal_metabolism0.80356013
82MP0003119_abnormal_digestive_system0.79770956
83MP0001765_abnormal_ion_homeostasis0.79497166
84MP0000230_abnormal_systemic_arterial0.79294843
85MP0000537_abnormal_urethra_morphology0.78640136
86MP0002152_abnormal_brain_morphology0.74463286
87MP0000534_abnormal_ureter_morphology0.72646057
88MP0002064_seizures0.72280912
89MP0005171_absent_coat_pigmentation0.71117071
90MP0001963_abnormal_hearing_physiology0.70222221
91MP0005389_reproductive_system_phenotype0.70053957
92MP0004130_abnormal_muscle_cell0.68955871
93MP0004811_abnormal_neuron_physiology0.68681211
94MP0002210_abnormal_sex_determination0.68217518
95MP0003878_abnormal_ear_physiology0.67619867
96MP0005377_hearing/vestibular/ear_phenot0.67619867
97MP0002090_abnormal_vision0.64777997
98MP0001286_abnormal_eye_development0.61249866
99MP0003942_abnormal_urinary_system0.60930491
100MP0005248_abnormal_Harderian_gland0.60909609

Predicted human phenotypes

RankGene SetZ-score
1Stenosis of the external auditory canal (HP:0000402)4.44251829
2Abnormality of midbrain morphology (HP:0002418)3.64830052
3Molar tooth sign on MRI (HP:0002419)3.64830052
4Acute necrotizing encephalopathy (HP:0006965)3.56517611
5Pancreatic cysts (HP:0001737)3.50801202
6True hermaphroditism (HP:0010459)3.43897519
7Nephronophthisis (HP:0000090)3.40765706
8Pancreatic fibrosis (HP:0100732)3.40443823
9Agitation (HP:0000713)3.35427440
10Chronic hepatic failure (HP:0100626)3.21031592
11Reticulocytopenia (HP:0001896)3.19383809
12Abnormal mitochondria in muscle tissue (HP:0008316)3.19324228
13Methylmalonic acidemia (HP:0002912)3.06350330
14Progressive macrocephaly (HP:0004481)3.01059418
15Abolished electroretinogram (ERG) (HP:0000550)2.99424917
16Severe visual impairment (HP:0001141)2.97862738
17Polyphagia (HP:0002591)2.96968654
18Mitochondrial inheritance (HP:0001427)2.87352192
19Pendular nystagmus (HP:0012043)2.83831325
20Acute encephalopathy (HP:0006846)2.83476817
21Type 2 muscle fiber atrophy (HP:0003554)2.78233520
22Abnormality of cells of the erythroid lineage (HP:0012130)2.72305642
23Abnormality of alanine metabolism (HP:0010916)2.71072167
24Hyperalaninemia (HP:0003348)2.71072167
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71072167
26Cerebral edema (HP:0002181)2.64028764
273-Methylglutaconic aciduria (HP:0003535)2.63498969
28Oligomenorrhea (HP:0000876)2.60692700
29Cortical dysplasia (HP:0002539)2.57783481
30Renal Fanconi syndrome (HP:0001994)2.54459805
31Abnormal rod and cone electroretinograms (HP:0008323)2.53698316
32Abnormality of the renal medulla (HP:0100957)2.51923247
33Abnormality of urine glucose concentration (HP:0011016)2.46460461
34Glycosuria (HP:0003076)2.46460461
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45941621
36Abnormality of homocysteine metabolism (HP:0010919)2.45861045
37Homocystinuria (HP:0002156)2.45861045
38Increased CSF lactate (HP:0002490)2.45729801
39Medial flaring of the eyebrow (HP:0010747)2.45450131
40Abnormality of the renal cortex (HP:0011035)2.41028753
41Increased hepatocellular lipid droplets (HP:0006565)2.38238165
42Generalized aminoaciduria (HP:0002909)2.37648591
43Abnormality of the labia minora (HP:0012880)2.35751169
44Gonadotropin excess (HP:0000837)2.35446011
45Cystic liver disease (HP:0006706)2.35002241
46Increased intramyocellular lipid droplets (HP:0012240)2.31454391
47Methylmalonic aciduria (HP:0012120)2.31035970
48Bifid tongue (HP:0010297)2.30029521
49Aplastic anemia (HP:0001915)2.29482884
50Megalencephaly (HP:0001355)2.26789560
51Morphological abnormality of the middle ear (HP:0008609)2.26693397
52Muscle fiber atrophy (HP:0100295)2.23068725
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20014331
54Abnormality of renal resorption (HP:0011038)2.17727367
55IgG deficiency (HP:0004315)2.15427639
56Congenital stationary night blindness (HP:0007642)2.13819127
57Abnormal lung lobation (HP:0002101)2.11236133
58Sclerocornea (HP:0000647)2.09922218
59Palpebral edema (HP:0100540)2.08508043
60Hepatic necrosis (HP:0002605)2.08455289
61Lipid accumulation in hepatocytes (HP:0006561)2.06726561
62Abnormality of macular pigmentation (HP:0008002)2.06562911
63Sleep apnea (HP:0010535)2.05848638
64Cerebral hypomyelination (HP:0006808)2.03929284
65Keratoconus (HP:0000563)2.01700848
66Increased corneal curvature (HP:0100692)2.01700848
67Optic disc pallor (HP:0000543)2.00976616
68Drooling (HP:0002307)1.97205880
69Renal cortical cysts (HP:0000803)1.96290900
70Leukodystrophy (HP:0002415)1.96072162
71Hepatocellular necrosis (HP:0001404)1.95510268
72Myokymia (HP:0002411)1.95144161
73Hyperphosphaturia (HP:0003109)1.93769348
74Congenital hepatic fibrosis (HP:0002612)1.93677198
75Abnormal pancreas size (HP:0012094)1.92805817
76Poor suck (HP:0002033)1.92770489
77Anencephaly (HP:0002323)1.92523461
78Narrow forehead (HP:0000341)1.91637848
79Lethargy (HP:0001254)1.90298035
80Abnormal number of erythroid precursors (HP:0012131)1.90259789
81Abnormal eating behavior (HP:0100738)1.89969157
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.89890193
83Postaxial hand polydactyly (HP:0001162)1.89519158
84Absent thumb (HP:0009777)1.88969784
85Male pseudohermaphroditism (HP:0000037)1.88127791
86Failure to thrive in infancy (HP:0001531)1.86076755
87Postaxial foot polydactyly (HP:0001830)1.82557604
88Focal seizures (HP:0007359)1.80978065
89Abnormal drinking behavior (HP:0030082)1.79117984
90Polydipsia (HP:0001959)1.79117984
91Excessive salivation (HP:0003781)1.78675990
92B lymphocytopenia (HP:0010976)1.78186116
93Increased muscle lipid content (HP:0009058)1.78004713
94Pachygyria (HP:0001302)1.76701055
95Acute hepatic failure (HP:0006554)1.76526465
96Tubular atrophy (HP:0000092)1.75080963
97Abnormal urine phosphate concentration (HP:0012599)1.74498412
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74435718
99Anophthalmia (HP:0000528)1.74144308
100Absent eyebrow (HP:0002223)1.69821188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.56427683
2CDK193.73749229
3ADRBK23.52411977
4WNK32.86930759
5PINK12.84890216
6WNK42.59051156
7GRK12.55131858
8MAP2K72.44761392
9BMPR1B2.40728416
10PDK22.34566850
11MAP3K122.29572173
12NTRK22.25411936
13NEK12.17742484
14MUSK2.13957384
15MAP3K42.12095836
16DYRK22.09608014
17FRK2.05307004
18TESK22.03882541
19TNK21.94826571
20VRK21.79289867
21KDR1.75568176
22TXK1.72251044
23PAK31.50840931
24TAOK21.45833425
25PRKCG1.34604988
26LIMK11.33791236
27MINK11.30252968
28PAK61.25833300
29MARK11.20747619
30SIK21.14847453
31ERBB31.08404984
32RPS6KA41.07130139
33MAPK130.98405164
34NUAK10.94980367
35BUB10.93241507
36EPHB20.89921932
37NTRK30.89396259
38STK390.89114490
39DAPK10.89051226
40CSNK1G30.87388369
41MAPKAPK30.86349885
42PRKCQ0.83339958
43CAMKK20.81009102
44NEK20.80518941
45SGK4940.78542983
46SGK2230.78542983
47MAP4K20.77696127
48FES0.74419585
49CSNK1G10.71145552
50ADRBK10.71052302
51BRSK10.70293777
52CSNK1G20.70149279
53NTRK10.69118076
54TRIM280.69032078
55MYLK0.68658451
56INSRR0.64909261
57CAMK10.64616737
58TNIK0.62697093
59AKT30.62251401
60VRK10.62214062
61ITK0.61777605
62CAMK2A0.59382381
63PRKD30.58808096
64PIK3CA0.58565380
65CSNK1A10.49552036
66TIE10.49539815
67OBSCN0.47794001
68ILK0.46526194
69TESK10.46104114
70ERBB20.44684175
71PLK10.44374574
72CSNK1A1L0.43732861
73WEE10.43500947
74PRKACA0.43130617
75CSNK2A10.41546108
76OXSR10.41389396
77CDK50.40241462
78PLK20.38688871
79PNCK0.37035028
80MAP3K110.36264713
81TYRO30.35915810
82CSNK2A20.35678707
83PRKCH0.35626219
84AURKA0.35485874
85PRKCA0.34618763
86MAPK150.34613410
87CDK11A0.34609424
88MAP2K40.33094544
89FYN0.31581877
90PRKCE0.30638498
91PAK10.30094139
92SGK20.29028912
93DYRK1B0.27696961
94SYK0.27660477
95LCK0.26925325
96PRKCB0.26836109
97RPS6KB10.26464994
98PRKACB0.26396163
99INSR0.25289191
100PRPF4B0.25139127

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.07677479
2Parkinsons disease_Homo sapiens_hsa050123.37925243
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.02379021
4Cardiac muscle contraction_Homo sapiens_hsa042603.02064562
5Ribosome_Homo sapiens_hsa030102.99144468
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74800536
7Steroid biosynthesis_Homo sapiens_hsa001002.73414859
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68597807
9Alzheimers disease_Homo sapiens_hsa050102.53306545
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.52360579
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.47919219
12Primary immunodeficiency_Homo sapiens_hsa053402.39153446
13Folate biosynthesis_Homo sapiens_hsa007902.22385081
14Huntingtons disease_Homo sapiens_hsa050162.20462673
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14789199
16Protein export_Homo sapiens_hsa030601.86458132
17Taste transduction_Homo sapiens_hsa047421.85624774
18Butanoate metabolism_Homo sapiens_hsa006501.84347278
19One carbon pool by folate_Homo sapiens_hsa006701.64660281
20Nicotine addiction_Homo sapiens_hsa050331.62730153
21Phototransduction_Homo sapiens_hsa047441.59184497
22Peroxisome_Homo sapiens_hsa041461.57960355
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55700144
24Caffeine metabolism_Homo sapiens_hsa002321.46610728
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44758847
26Proteasome_Homo sapiens_hsa030501.41818293
27Regulation of autophagy_Homo sapiens_hsa041401.37031121
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31619200
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.30816987
30Propanoate metabolism_Homo sapiens_hsa006401.27403575
31Homologous recombination_Homo sapiens_hsa034401.22697073
32Nitrogen metabolism_Homo sapiens_hsa009101.17596008
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08339178
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03202295
35Linoleic acid metabolism_Homo sapiens_hsa005910.96408339
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94620669
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92928629
38GABAergic synapse_Homo sapiens_hsa047270.91163202
39Ether lipid metabolism_Homo sapiens_hsa005650.87665610
40Tryptophan metabolism_Homo sapiens_hsa003800.86820949
41Pyruvate metabolism_Homo sapiens_hsa006200.84418656
42Morphine addiction_Homo sapiens_hsa050320.82945928
43Olfactory transduction_Homo sapiens_hsa047400.82385287
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81886309
45Hedgehog signaling pathway_Homo sapiens_hsa043400.81475066
46RNA polymerase_Homo sapiens_hsa030200.79645543
47Fanconi anemia pathway_Homo sapiens_hsa034600.78751764
48Chemical carcinogenesis_Homo sapiens_hsa052040.78569524
49Fatty acid elongation_Homo sapiens_hsa000620.78419144
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77757643
51Dopaminergic synapse_Homo sapiens_hsa047280.74667673
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70937027
53Retinol metabolism_Homo sapiens_hsa008300.70175007
54Amphetamine addiction_Homo sapiens_hsa050310.69493692
55Serotonergic synapse_Homo sapiens_hsa047260.69435014
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69424202
57Fatty acid biosynthesis_Homo sapiens_hsa000610.66997221
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.64931327
59ABC transporters_Homo sapiens_hsa020100.64690364
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64123283
61Metabolic pathways_Homo sapiens_hsa011000.60991731
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58577013
63Hematopoietic cell lineage_Homo sapiens_hsa046400.54671128
64Insulin secretion_Homo sapiens_hsa049110.52378901
65Salmonella infection_Homo sapiens_hsa051320.51457931
66Basal transcription factors_Homo sapiens_hsa030220.51312382
67Axon guidance_Homo sapiens_hsa043600.50918337
68Basal cell carcinoma_Homo sapiens_hsa052170.50121112
69Cocaine addiction_Homo sapiens_hsa050300.49968182
70Fat digestion and absorption_Homo sapiens_hsa049750.49326438
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48513021
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47253117
73Fatty acid degradation_Homo sapiens_hsa000710.46525433
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45566461
75Glutamatergic synapse_Homo sapiens_hsa047240.45014780
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42811655
77Purine metabolism_Homo sapiens_hsa002300.41811290
78Graft-versus-host disease_Homo sapiens_hsa053320.41326611
79Antigen processing and presentation_Homo sapiens_hsa046120.40634318
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39574819
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39458715
82T cell receptor signaling pathway_Homo sapiens_hsa046600.39075633
83Cholinergic synapse_Homo sapiens_hsa047250.38902038
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38819562
85Arachidonic acid metabolism_Homo sapiens_hsa005900.38600035
86Ras signaling pathway_Homo sapiens_hsa040140.37565815
87cAMP signaling pathway_Homo sapiens_hsa040240.37193994
88Circadian entrainment_Homo sapiens_hsa047130.36909140
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.36784020
90Oxytocin signaling pathway_Homo sapiens_hsa049210.36724600
91Fatty acid metabolism_Homo sapiens_hsa012120.36108742
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35860462
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34790020
94Melanoma_Homo sapiens_hsa052180.33255443
95Pyrimidine metabolism_Homo sapiens_hsa002400.30779719
96Synaptic vesicle cycle_Homo sapiens_hsa047210.29535129
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28879087
98Calcium signaling pathway_Homo sapiens_hsa040200.28864152
99Dilated cardiomyopathy_Homo sapiens_hsa054140.27748391
100Ovarian steroidogenesis_Homo sapiens_hsa049130.27122645

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