UBOX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.96027445
2DNA strand elongation involved in DNA replication (GO:0006271)4.85391624
3nucleobase biosynthetic process (GO:0046112)4.72281354
4DNA unwinding involved in DNA replication (GO:0006268)4.70612833
5DNA strand elongation (GO:0022616)4.61320353
6DNA replication initiation (GO:0006270)4.55138031
7DNA deamination (GO:0045006)4.40820365
8IMP biosynthetic process (GO:0006188)4.32714765
9telomere maintenance via semi-conservative replication (GO:0032201)4.29891559
10maturation of SSU-rRNA (GO:0030490)4.29187471
11purine nucleobase biosynthetic process (GO:0009113)4.27895530
12platelet dense granule organization (GO:0060155)4.21307487
13DNA replication checkpoint (GO:0000076)4.18792169
14DNA replication-dependent nucleosome assembly (GO:0006335)4.03664836
15DNA replication-dependent nucleosome organization (GO:0034723)4.03664836
16mitotic metaphase plate congression (GO:0007080)3.99904255
17folic acid-containing compound biosynthetic process (GO:0009396)3.97673611
18folic acid metabolic process (GO:0046655)3.95991479
19mitotic nuclear envelope disassembly (GO:0007077)3.95235508
20protein localization to kinetochore (GO:0034501)3.93121874
21telomere maintenance via recombination (GO:0000722)3.88593655
22ribosomal small subunit assembly (GO:0000028)3.86825569
23formation of translation preinitiation complex (GO:0001731)3.83050063
24ribosome biogenesis (GO:0042254)3.75346565
25L-fucose catabolic process (GO:0042355)3.73874919
26fucose catabolic process (GO:0019317)3.73874919
27L-fucose metabolic process (GO:0042354)3.73874919
28response to pheromone (GO:0019236)3.70165976
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.68650971
30membrane disassembly (GO:0030397)3.67037432
31nuclear envelope disassembly (GO:0051081)3.67037432
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.64062006
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.64062006
34telomere maintenance via telomere lengthening (GO:0010833)3.61487925
35mitotic recombination (GO:0006312)3.60566659
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.59448996
37metaphase plate congression (GO:0051310)3.56076032
38nuclear pore organization (GO:0006999)3.54395719
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.54311192
40IMP metabolic process (GO:0046040)3.50860088
41spliceosomal complex assembly (GO:0000245)3.50355427
42spliceosomal snRNP assembly (GO:0000387)3.49868955
43piRNA metabolic process (GO:0034587)3.48692617
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47778222
45CENP-A containing nucleosome assembly (GO:0034080)3.42241089
46regulation of translation in response to stress (GO:0043555)3.41292585
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41291860
48chromatin remodeling at centromere (GO:0031055)3.41018755
49protein localization to chromosome, centromeric region (GO:0071459)3.39682905
50tryptophan catabolic process (GO:0006569)3.39623412
51indole-containing compound catabolic process (GO:0042436)3.39623412
52indolalkylamine catabolic process (GO:0046218)3.39623412
53ribosome assembly (GO:0042255)3.39332591
54negative regulation of telomere maintenance (GO:0032205)3.36932356
55kynurenine metabolic process (GO:0070189)3.36564070
56ribosomal large subunit biogenesis (GO:0042273)3.34777697
57pseudouridine synthesis (GO:0001522)3.33699187
58transcription-coupled nucleotide-excision repair (GO:0006283)3.33551478
59nuclear pore complex assembly (GO:0051292)3.30606187
60DNA replication-independent nucleosome assembly (GO:0006336)3.30568773
61DNA replication-independent nucleosome organization (GO:0034724)3.30568773
62protein-cofactor linkage (GO:0018065)3.27739208
63indolalkylamine metabolic process (GO:0006586)3.27540891
64signal peptide processing (GO:0006465)3.27053408
65rRNA processing (GO:0006364)3.25111109
66respiratory chain complex IV assembly (GO:0008535)3.23260559
67ribonucleoprotein complex biogenesis (GO:0022613)3.22373552
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22370513
69peptidyl-arginine omega-N-methylation (GO:0035247)3.21129700
70regulation of protein heterodimerization activity (GO:0043497)3.19839745
71regulation of spindle organization (GO:0090224)3.17780279
72viral mRNA export from host cell nucleus (GO:0046784)3.17438324
73maturation of 5.8S rRNA (GO:0000460)3.16437859
74water-soluble vitamin biosynthetic process (GO:0042364)3.15467512
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14936229
76rRNA metabolic process (GO:0016072)3.14610210
77mannosylation (GO:0097502)3.12230853
78protein complex biogenesis (GO:0070271)3.11232509
79establishment of chromosome localization (GO:0051303)3.08761526
80snRNA metabolic process (GO:0016073)3.08156852
81preassembly of GPI anchor in ER membrane (GO:0016254)3.07413518
82cellular response to ATP (GO:0071318)3.07336964
83histone H2A acetylation (GO:0043968)3.07167092
84tryptophan metabolic process (GO:0006568)3.06596236
85histone exchange (GO:0043486)3.06009617
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04757470
87mitochondrial respiratory chain complex I assembly (GO:0032981)3.04757470
88NADH dehydrogenase complex assembly (GO:0010257)3.04757470
89attachment of spindle microtubules to kinetochore (GO:0008608)3.04470019
90DNA geometric change (GO:0032392)3.04375878
91mismatch repair (GO:0006298)3.03685977
92methionine biosynthetic process (GO:0009086)3.02742255
93neural tube formation (GO:0001841)3.02431886
94protein K11-linked deubiquitination (GO:0035871)3.01308730
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01288042
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00924977
97negative regulation of sister chromatid segregation (GO:0033046)3.00924977
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.00924977
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00924977
100DNA duplex unwinding (GO:0032508)3.00680325
101negative regulation of chromosome segregation (GO:0051985)2.99989449
102mitotic spindle assembly checkpoint (GO:0007094)2.98739309
103histone arginine methylation (GO:0034969)2.98295890
104mitotic sister chromatid segregation (GO:0000070)2.98243607
105photoreceptor cell maintenance (GO:0045494)2.98228062
106detection of light stimulus involved in visual perception (GO:0050908)2.96432994
107detection of light stimulus involved in sensory perception (GO:0050962)2.96432994
108axoneme assembly (GO:0035082)2.96303066
109intra-S DNA damage checkpoint (GO:0031573)2.96249278
110cytochrome complex assembly (GO:0017004)2.95907699
111spindle assembly checkpoint (GO:0071173)2.95837778
112auditory receptor cell stereocilium organization (GO:0060088)2.94414181
113RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.93584618
114mRNA splicing, via spliceosome (GO:0000398)2.93584618
115postreplication repair (GO:0006301)2.93482710
116RNA splicing, via transesterification reactions (GO:0000375)2.93419051
117ubiquinone biosynthetic process (GO:0006744)2.92634895
118regulation of centrosome cycle (GO:0046605)2.91978437
119G1/S transition of mitotic cell cycle (GO:0000082)2.91133472
120cell cycle G1/S phase transition (GO:0044843)2.91133472
1217-methylguanosine mRNA capping (GO:0006370)2.90044263
122proteasome assembly (GO:0043248)2.89827647
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89510864
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89371291
125purinergic nucleotide receptor signaling pathway (GO:0035590)2.88508226
126mitotic G1 DNA damage checkpoint (GO:0031571)2.88071782
127snRNA processing (GO:0016180)2.87742168
128telomere organization (GO:0032200)2.87350959
129negative regulation of mast cell activation (GO:0033004)2.87216048
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87018551
131spindle checkpoint (GO:0031577)2.86736870
132regulation of chromosome segregation (GO:0051983)2.86733079
133telomere maintenance (GO:0000723)2.86179365
134kinetochore organization (GO:0051383)2.86089279
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85713075
136ATP-dependent chromatin remodeling (GO:0043044)2.84793653
137L-serine metabolic process (GO:0006563)2.84708756
138nuclear envelope organization (GO:0006998)2.82112803
139cellular ketone body metabolic process (GO:0046950)2.79409180
140anterograde synaptic vesicle transport (GO:0048490)2.79122785
141mitochondrial respiratory chain complex assembly (GO:0033108)2.77876478
142RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77618669
143ubiquinone metabolic process (GO:0006743)2.73988294
144S-adenosylmethionine metabolic process (GO:0046500)2.72581789
145regulation of meiosis I (GO:0060631)2.72516232
146DNA double-strand break processing (GO:0000729)2.71947868
147protein polyglutamylation (GO:0018095)2.71146687
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69352903
149positive regulation of defense response to virus by host (GO:0002230)2.67549075
150DNA methylation involved in gamete generation (GO:0043046)2.66711711
151rhodopsin mediated signaling pathway (GO:0016056)2.66698684
152regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64080572
153activated T cell proliferation (GO:0050798)2.61895626
154RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59803951
155tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59803951
156regulation of cilium movement (GO:0003352)2.59424646
157NAD biosynthetic process (GO:0009435)2.58370844
158ketone body metabolic process (GO:1902224)2.54218115
159arginine catabolic process (GO:0006527)2.54155786
160adaptation of signaling pathway (GO:0023058)2.53306790
161nonmotile primary cilium assembly (GO:0035058)2.53248281
162pyrimidine nucleobase catabolic process (GO:0006208)2.51128585
163negative regulation of JAK-STAT cascade (GO:0046426)2.48991888
164amine catabolic process (GO:0009310)2.48533548
165cellular biogenic amine catabolic process (GO:0042402)2.48533548
166negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45341055
167neuronal action potential (GO:0019228)2.44836958
168negative regulation of cAMP-mediated signaling (GO:0043951)2.43284609
169positive regulation of fatty acid transport (GO:2000193)2.42943755
170regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.42112568
171regulation of telomere maintenance (GO:0032204)2.42067929
172gamma-aminobutyric acid transport (GO:0015812)2.41673063
173reflex (GO:0060004)2.41186833
174synapsis (GO:0007129)2.39866347
175positive regulation of prostaglandin secretion (GO:0032308)2.39063947
176glycosphingolipid biosynthetic process (GO:0006688)2.38801928
177RNA destabilization (GO:0050779)2.36421970
178amino acid salvage (GO:0043102)2.35473981
179L-methionine salvage (GO:0071267)2.35473981
180L-methionine biosynthetic process (GO:0071265)2.35473981
181GPI anchor metabolic process (GO:0006505)2.34946633
182recombinational repair (GO:0000725)2.34723523
183epithelial cilium movement (GO:0003351)2.31795984
184retinal cone cell development (GO:0046549)2.31730070
185cytidine metabolic process (GO:0046087)2.30998182
186cytidine catabolic process (GO:0006216)2.30998182
187cytidine deamination (GO:0009972)2.30998182
188phosphatidylinositol acyl-chain remodeling (GO:0036149)2.30022617
189regulation of hippo signaling (GO:0035330)2.29897950
190multicellular organism reproduction (GO:0032504)2.29758907
191double-strand break repair via homologous recombination (GO:0000724)2.29360408
192organelle membrane fusion (GO:0090174)2.29170806
193negative regulation of DNA-dependent DNA replication (GO:2000104)2.28999060
194adenosine metabolic process (GO:0046085)2.28846205
195cilium morphogenesis (GO:0060271)2.28561218
196inner ear receptor stereocilium organization (GO:0060122)2.28151145
197indole-containing compound metabolic process (GO:0042430)2.27953711
198negative regulation of interleukin-1 production (GO:0032692)2.27318483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19910354
2ZNF274_21170338_ChIP-Seq_K562_Hela4.72018673
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.24841930
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68969253
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.33925356
6VDR_22108803_ChIP-Seq_LS180_Human3.33139292
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24556088
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16086570
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.11039051
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01686131
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01561643
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97661810
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90425096
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.89064498
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89031769
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88345527
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88238933
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.85004835
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.77357698
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.74530000
21IGF1R_20145208_ChIP-Seq_DFB_Human2.73627273
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69769451
23XRN2_22483619_ChIP-Seq_HELA_Human2.53023222
24GBX2_23144817_ChIP-Seq_PC3_Human2.50257874
25EZH2_22144423_ChIP-Seq_EOC_Human2.45158636
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42729874
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41082995
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34970738
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33833132
30VDR_23849224_ChIP-Seq_CD4+_Human2.24086241
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23731629
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23595562
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21707878
34* FOXP3_21729870_ChIP-Seq_TREG_Human2.15102054
35EGR1_19374776_ChIP-ChIP_THP-1_Human2.12935766
36FLI1_27457419_Chip-Seq_LIVER_Mouse2.11001528
37DCP1A_22483619_ChIP-Seq_HELA_Human2.08198207
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05675739
39* GABP_19822575_ChIP-Seq_HepG2_Human2.05403200
40E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03278653
41ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02962377
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99857046
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97117109
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96466643
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.95314470
46AR_21909140_ChIP-Seq_LNCAP_Human1.93406257
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92195012
48ER_23166858_ChIP-Seq_MCF-7_Human1.91330695
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90701135
50MYC_22102868_ChIP-Seq_BL_Human1.88285292
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86106926
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84467232
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82847548
54CIITA_25753668_ChIP-Seq_RAJI_Human1.78954276
55* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78220267
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76900784
57EWS_26573619_Chip-Seq_HEK293_Human1.72636067
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70924287
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70165776
60TTF2_22483619_ChIP-Seq_HELA_Human1.69984109
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68979201
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67420325
63TP53_22573176_ChIP-Seq_HFKS_Human1.66426908
64P300_19829295_ChIP-Seq_ESCs_Human1.66400213
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65623120
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64561482
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62363460
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62212994
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58429563
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.58323791
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.58222614
72BCAT_22108803_ChIP-Seq_LS180_Human1.57027561
73* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54268962
74KDM5A_27292631_Chip-Seq_BREAST_Human1.54028000
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53983426
76IRF1_19129219_ChIP-ChIP_H3396_Human1.51999214
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51367667
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50603511
79ELK1_19687146_ChIP-ChIP_HELA_Human1.50533111
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43297851
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42549154
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40218395
83CBP_20019798_ChIP-Seq_JUKART_Human1.39780716
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39780716
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.37197344
86* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35986604
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35444687
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.35444687
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35443884
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.34172524
91TAF15_26573619_Chip-Seq_HEK293_Human1.33671891
92GATA3_26560356_Chip-Seq_TH2_Human1.32646812
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31526860
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31174824
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30431121
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28146330
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28146330
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27110794
99ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27062910
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26605266
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26437514
102HOXB7_26014856_ChIP-Seq_BT474_Human1.25495735
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25290955
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24721216
105STAT3_23295773_ChIP-Seq_U87_Human1.23586054
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23211078
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22982296
108TFEB_21752829_ChIP-Seq_HELA_Human1.22018047
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21321446
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.21216539
111AR_25329375_ChIP-Seq_VCAP_Human1.20332034
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20313799
113SOX2_19829295_ChIP-Seq_ESCs_Human1.20239229
114NANOG_19829295_ChIP-Seq_ESCs_Human1.20239229
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20109242
116NCOR_22424771_ChIP-Seq_293T_Human1.19429215
117AR_20517297_ChIP-Seq_VCAP_Human1.18214512
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17192497
119* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17109645
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17024221
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16762486
122* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15433717
123SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15350056
124RUNX_20019798_ChIP-Seq_JUKART_Human1.15090692
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13434583
126TP63_19390658_ChIP-ChIP_HaCaT_Human1.13142440
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11673238
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11253766
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11161828
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.11085729
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10916268
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10410127
133EZH2_27294783_Chip-Seq_NPCs_Mouse1.09924436
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09619832
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09305068
136TCF4_23295773_ChIP-Seq_U87_Human1.09260973
137MYC_19829295_ChIP-Seq_ESCs_Human1.08975572
138REST_21632747_ChIP-Seq_MESCs_Mouse1.08756552
139ERA_21632823_ChIP-Seq_H3396_Human1.08653626
140TCF4_22108803_ChIP-Seq_LS180_Human1.08449196
141SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08419483
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08302327
143FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07214826
144FUS_26573619_Chip-Seq_HEK293_Human1.06152078
145SMAD4_21799915_ChIP-Seq_A2780_Human1.05862989
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05360549
147RUNX2_22187159_ChIP-Seq_PCA_Human1.04984321
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04530308
149EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04264255
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.02699368
151NFE2_27457419_Chip-Seq_LIVER_Mouse1.02490299
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01462647
153SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01134598
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00763478
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00612727
156NANOG_21062744_ChIP-ChIP_HESCs_Human1.00148978
157GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99597082
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98929025
159CRX_20693478_ChIP-Seq_RETINA_Mouse0.98871031
160KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98404610
161NANOG_20526341_ChIP-Seq_ESCs_Human0.97642417
162GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97402582
163SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96503778
164TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96271949
165* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96261852
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96224234
167TAF2_19829295_ChIP-Seq_ESCs_Human0.95445552
168* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93527537
169CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93041012
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.92051089
171SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91217337
172SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88380273
173KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87747909
174KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87747909
175KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87747909
176* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86808196
177MYC_18940864_ChIP-ChIP_HL60_Human0.81016976
178ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80160816
179SPI1_23547873_ChIP-Seq_NB4_Human0.76334703
180* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76263469
181KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75221405
182TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74498426
183CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73611767
184HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.72819420
185VDR_21846776_ChIP-Seq_THP-1_Human0.72647891
186SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70461674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.26446468
2MP0010094_abnormal_chromosome_stability4.59523202
3MP0003111_abnormal_nucleus_morphology4.51072736
4MP0004957_abnormal_blastocyst_morpholog4.12223231
5MP0003077_abnormal_cell_cycle3.92736817
6MP0008057_abnormal_DNA_replication3.80651972
7MP0008058_abnormal_DNA_repair3.34868031
8MP0008007_abnormal_cellular_replicative2.98933133
9MP0002138_abnormal_hepatobiliary_system2.98248237
10MP0003195_calcinosis2.93618988
11MP0008932_abnormal_embryonic_tissue2.73125242
12MP0001730_embryonic_growth_arrest2.66823093
13MP0003123_paternal_imprinting2.66024738
14MP0008877_abnormal_DNA_methylation2.61422241
15MP0002396_abnormal_hematopoietic_system2.47452247
16MP0001968_abnormal_touch/_nociception2.43702376
17MP0005084_abnormal_gallbladder_morpholo2.39785887
18MP0003806_abnormal_nucleotide_metabolis2.36516888
19MP0002653_abnormal_ependyma_morphology2.36318027
20MP0002102_abnormal_ear_morphology2.34364650
21MP0010352_gastrointestinal_tract_polyps2.25322171
22MP0000350_abnormal_cell_proliferation2.19986797
23MP0003646_muscle_fatigue2.10827364
24MP0003786_premature_aging2.08289833
25MP0001293_anophthalmia2.03399834
26MP0005551_abnormal_eye_electrophysiolog1.99574919
27MP0002736_abnormal_nociception_after1.92996785
28MP0000372_irregular_coat_pigmentation1.91435142
29MP0001501_abnormal_sleep_pattern1.89207209
30MP0005174_abnormal_tail_pigmentation1.85550759
31MP0002837_dystrophic_cardiac_calcinosis1.85195770
32MP0010307_abnormal_tumor_latency1.81890207
33MP0001697_abnormal_embryo_size1.81744135
34MP0005377_hearing/vestibular/ear_phenot1.78695789
35MP0003878_abnormal_ear_physiology1.78695789
36MP0001672_abnormal_embryogenesis/_devel1.73449884
37MP0005380_embryogenesis_phenotype1.73449884
38MP0008872_abnormal_physiological_respon1.72506368
39MP0005671_abnormal_response_to1.67726148
40MP0002876_abnormal_thyroid_physiology1.67386050
41MP0001986_abnormal_taste_sensitivity1.67218052
42MP0004885_abnormal_endolymph1.64787478
43MP0002080_prenatal_lethality1.64754258
44MP0002928_abnormal_bile_duct1.63283622
45MP0005645_abnormal_hypothalamus_physiol1.62194601
46MP0004808_abnormal_hematopoietic_stem1.62016522
47MP0003724_increased_susceptibility_to1.61399361
48MP0003787_abnormal_imprinting1.61093981
49MP0002210_abnormal_sex_determination1.57900022
50MP0003984_embryonic_growth_retardation1.57353598
51MP0002088_abnormal_embryonic_growth/wei1.54197098
52MP0000313_abnormal_cell_death1.52376967
53MP0005253_abnormal_eye_physiology1.50772833
54MP0003136_yellow_coat_color1.49130007
55MP0002085_abnormal_embryonic_tissue1.48603418
56MP0008875_abnormal_xenobiotic_pharmacok1.45308613
57MP0001145_abnormal_male_reproductive1.44652942
58MP0006072_abnormal_retinal_apoptosis1.43651137
59MP0004133_heterotaxia1.40602054
60MP0004142_abnormal_muscle_tone1.40248910
61MP0002084_abnormal_developmental_patter1.37678230
62MP0009745_abnormal_behavioral_response1.37407164
63MP0001929_abnormal_gametogenesis1.36484497
64MP0002277_abnormal_respiratory_mucosa1.36472224
65MP0002638_abnormal_pupillary_reflex1.36012966
66MP0003011_delayed_dark_adaptation1.34009815
67MP0002086_abnormal_extraembryonic_tissu1.33801821
68MP0009046_muscle_twitch1.31797050
69MP0004742_abnormal_vestibular_system1.31300689
70MP0004197_abnormal_fetal_growth/weight/1.30893183
71MP0005187_abnormal_penis_morphology1.29250931
72MP0000653_abnormal_sex_gland1.27092349
73MP0003718_maternal_effect1.25988556
74MP0001485_abnormal_pinna_reflex1.24899334
75MP0002019_abnormal_tumor_incidence1.24482716
76MP0003890_abnormal_embryonic-extraembry1.23748928
77MP0004145_abnormal_muscle_electrophysio1.23703457
78MP0001984_abnormal_olfaction1.21519699
79MP0009672_abnormal_birth_weight1.19792832
80MP0002163_abnormal_gland_morphology1.19706528
81MP0004043_abnormal_pH_regulation1.18914348
82MP0000490_abnormal_crypts_of1.17421383
83MP0010030_abnormal_orbit_morphology1.17272620
84MP0003283_abnormal_digestive_organ1.16538745
85MP0002272_abnormal_nervous_system1.16393058
86MP0006276_abnormal_autonomic_nervous1.16295453
87MP0003315_abnormal_perineum_morphology1.15906113
88MP0005076_abnormal_cell_differentiation1.15519177
89MP0002733_abnormal_thermal_nociception1.13349501
90MP0003763_abnormal_thymus_physiology1.13089379
91MP0001486_abnormal_startle_reflex1.12870520
92MP0000703_abnormal_thymus_morphology1.12150169
93MP0005646_abnormal_pituitary_gland1.11795581
94MP0000685_abnormal_immune_system1.11624902
95MP0009764_decreased_sensitivity_to1.09960588
96MP0005410_abnormal_fertilization1.09563553
97MP0009333_abnormal_splenocyte_physiolog1.09204519
98MP0005379_endocrine/exocrine_gland_phen1.08532204
99MP0003121_genomic_imprinting1.08226978
100MP0001790_abnormal_immune_system1.07316383
101MP0005387_immune_system_phenotype1.07316383
102MP0003119_abnormal_digestive_system1.05372617
103MP0002148_abnormal_hypersensitivity_rea1.04376041
104MP0005167_abnormal_blood-brain_barrier1.03364763
105MP0009703_decreased_birth_body1.00880463
106MP0005075_abnormal_melanosome_morpholog1.00287596
107MP0003252_abnormal_bile_duct0.98781994
108MP0005367_renal/urinary_system_phenotyp0.98517411
109MP0000516_abnormal_urinary_system0.98517411
110MP0002160_abnormal_reproductive_system0.98367350
111MP0002064_seizures0.97817600
112MP0001800_abnormal_humoral_immune0.97812195
113MP0002398_abnormal_bone_marrow0.96784888
114MP0002572_abnormal_emotion/affect_behav0.96546926
115MP0001119_abnormal_female_reproductive0.96063166
116MP0004084_abnormal_cardiac_muscle0.95904691
117MP0005397_hematopoietic_system_phenotyp0.95697027
118MP0001545_abnormal_hematopoietic_system0.95697027
119MP0002693_abnormal_pancreas_physiology0.95629146
120MP0002735_abnormal_chemical_nociception0.95550703
121MP0002557_abnormal_social/conspecific_i0.94452524
122MP0009697_abnormal_copulation0.92179224
123MP0000631_abnormal_neuroendocrine_gland0.91832945
124MP0003567_abnormal_fetal_cardiomyocyte0.91756402
125MP0002067_abnormal_sensory_capabilities0.91524620
126MP0005389_reproductive_system_phenotype0.91487013
127MP0008961_abnormal_basal_metabolism0.91202695
128MP0002254_reproductive_system_inflammat0.90913692
129MP0002722_abnormal_immune_system0.90721977
130MP0003698_abnormal_male_reproductive0.90457647
131MP0001970_abnormal_pain_threshold0.90454272
132MP0005083_abnormal_biliary_tract0.88281977
133MP0002723_abnormal_immune_serum0.88102106
134MP0000689_abnormal_spleen_morphology0.88014618
135MP0009785_altered_susceptibility_to0.87543207
136MP0002111_abnormal_tail_morphology0.85497767
137MP0000230_abnormal_systemic_arterial0.84849020
138MP0000358_abnormal_cell_content/0.84341553
139MP0001905_abnormal_dopamine_level0.83909175
140MP0008770_decreased_survivor_rate0.83852486
141MP0000613_abnormal_salivary_gland0.83830477
142MP0004233_abnormal_muscle_weight0.83193253
143MP0005310_abnormal_salivary_gland0.82455277
144MP0001529_abnormal_vocalization0.82218583
145MP0005384_cellular_phenotype0.82155879
146MP0003186_abnormal_redox_activity0.82023485
147MP0001764_abnormal_homeostasis0.81132175
148MP0010386_abnormal_urinary_bladder0.80795437
149MP0002938_white_spotting0.80529787
150MP0005408_hypopigmentation0.80337306
151MP0001324_abnormal_eye_pigmentation0.80138964
152MP0008995_early_reproductive_senescence0.79459599
153MP0000427_abnormal_hair_cycle0.78600507
154MP0001915_intracranial_hemorrhage0.78314388
155MP0005621_abnormal_cell_physiology0.77970502
156MP0006054_spinal_hemorrhage0.77319253
157MP0003880_abnormal_central_pattern0.75795320
158MP0002420_abnormal_adaptive_immunity0.75575038
159MP0002092_abnormal_eye_morphology0.75223136
160MP0000858_altered_metastatic_potential0.74367808
161MP0003705_abnormal_hypodermis_morpholog0.73151930
162MP0001819_abnormal_immune_cell0.72717089
163MP0002161_abnormal_fertility/fecundity0.72468641
164MP0001919_abnormal_reproductive_system0.71017549
165MP0002429_abnormal_blood_cell0.70789441
166MP0006036_abnormal_mitochondrial_physio0.70695012
167MP0009053_abnormal_anal_canal0.69069562
168MP0000569_abnormal_digit_pigmentation0.68281056
169MP0003172_abnormal_lysosome_physiology0.68126293
170MP0003699_abnormal_female_reproductive0.67908967
171MP0003221_abnormal_cardiomyocyte_apopto0.66303894
172MP0002269_muscular_atrophy0.66268009
173MP0005266_abnormal_metabolism0.65935127
174MP0002751_abnormal_autonomic_nervous0.65710503
175MP0004147_increased_porphyrin_level0.65425714
176MP0002095_abnormal_skin_pigmentation0.64999789
177MP0008260_abnormal_autophagy0.64898503
178MP0003115_abnormal_respiratory_system0.63603053
179MP0000015_abnormal_ear_pigmentation0.63097969
180MP0003566_abnormal_cell_adhesion0.62291815
181MP0001286_abnormal_eye_development0.60667123

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.76427782
2Breast hypoplasia (HP:0003187)4.56096523
3Oral leukoplakia (HP:0002745)4.27022145
4Pancreatic cysts (HP:0001737)4.24396488
5Abnormality of the anterior horn cell (HP:0006802)4.17494701
6Degeneration of anterior horn cells (HP:0002398)4.17494701
7Ependymoma (HP:0002888)4.03459489
8True hermaphroditism (HP:0010459)3.79393345
9Aplastic anemia (HP:0001915)3.78609867
10Agnosia (HP:0010524)3.76072053
11Colon cancer (HP:0003003)3.75441292
12Cerebral hypomyelination (HP:0006808)3.72351478
13Abnormality of midbrain morphology (HP:0002418)3.66934808
14Molar tooth sign on MRI (HP:0002419)3.66934808
15Medulloblastoma (HP:0002885)3.66782744
16Stomatitis (HP:0010280)3.55456936
17Selective tooth agenesis (HP:0001592)3.48856490
18Abolished electroretinogram (ERG) (HP:0000550)3.36315663
19Congenital stationary night blindness (HP:0007642)3.34123003
20Type II lissencephaly (HP:0007260)3.33974401
21Nephronophthisis (HP:0000090)3.32558950
22Patellar aplasia (HP:0006443)3.27801789
23Aplasia/Hypoplasia of the patella (HP:0006498)3.04630698
24Megaloblastic anemia (HP:0001889)3.03346355
25Gaze-evoked nystagmus (HP:0000640)3.00760032
26Attenuation of retinal blood vessels (HP:0007843)2.98479992
27Abnormality of the renal medulla (HP:0100957)2.89750567
28Depressed nasal tip (HP:0000437)2.86372973
29Abnormality of homocysteine metabolism (HP:0010919)2.84000015
30Homocystinuria (HP:0002156)2.84000015
31Rough bone trabeculation (HP:0100670)2.76048986
32Neoplasm of the pancreas (HP:0002894)2.75530618
33Astrocytoma (HP:0009592)2.73412821
34Abnormality of the astrocytes (HP:0100707)2.73412821
35Premature graying of hair (HP:0002216)2.71451997
36Carpal bone hypoplasia (HP:0001498)2.65734783
37Inability to walk (HP:0002540)2.65691228
38Medial flaring of the eyebrow (HP:0010747)2.65514536
39Stomach cancer (HP:0012126)2.65144162
40Impulsivity (HP:0100710)2.63326374
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.63104361
42Abnormality of the renal cortex (HP:0011035)2.62323845
43Reticulocytopenia (HP:0001896)2.59658724
44Hyperventilation (HP:0002883)2.59249461
45Hypothermia (HP:0002045)2.58932148
46Glioma (HP:0009733)2.57264659
47Cystic liver disease (HP:0006706)2.56593497
48Postnatal microcephaly (HP:0005484)2.54813326
49Abnormality of the labia minora (HP:0012880)2.48169845
50Progressive inability to walk (HP:0002505)2.47687513
51Abnormal rod and cone electroretinograms (HP:0008323)2.45767165
52Macrocytic anemia (HP:0001972)2.43680545
53Abnormal biliary tract physiology (HP:0012439)2.40491279
54Bile duct proliferation (HP:0001408)2.40491279
55Rhabdomyosarcoma (HP:0002859)2.38818600
56Tongue fasciculations (HP:0001308)2.37645757
57Abnormality of cells of the erythroid lineage (HP:0012130)2.36969248
58Short middle phalanx of the 5th finger (HP:0004220)2.36888081
59Supernumerary spleens (HP:0009799)2.33844000
60Chromsome breakage (HP:0040012)2.33803559
61Abnormal number of erythroid precursors (HP:0012131)2.32988840
62Optic nerve coloboma (HP:0000588)2.32001186
63Large for gestational age (HP:0001520)2.31463311
64Myelodysplasia (HP:0002863)2.30843837
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30433228
66Bone marrow hypocellularity (HP:0005528)2.29143893
67Albinism (HP:0001022)2.28721071
68Lissencephaly (HP:0001339)2.27593429
69Amyotrophic lateral sclerosis (HP:0007354)2.26834363
70Amaurosis fugax (HP:0100576)2.25173097
71Basal cell carcinoma (HP:0002671)2.24823161
72Abnormal number of incisors (HP:0011064)2.24667949
73Slender long bone (HP:0003100)2.24227008
74Increased CSF lactate (HP:0002490)2.23593808
75Sclerocornea (HP:0000647)2.23093700
76Increased nuchal translucency (HP:0010880)2.22669692
77Neoplasm of the oral cavity (HP:0100649)2.22506692
78Abnormal spermatogenesis (HP:0008669)2.22396612
79Hepatocellular necrosis (HP:0001404)2.22286850
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.20913208
81Abnormality of the pons (HP:0007361)2.20001251
82Abnormal drinking behavior (HP:0030082)2.19928279
83Polydipsia (HP:0001959)2.19928279
84Absent radius (HP:0003974)2.19274812
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19112001
86Meckel diverticulum (HP:0002245)2.18411990
87Blepharitis (HP:0000498)2.16445830
88Increased serum pyruvate (HP:0003542)2.15459484
89Abnormality of glycolysis (HP:0004366)2.15459484
90Abnormality of the ileum (HP:0001549)2.15362184
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15226187
92Neoplasm of striated muscle (HP:0009728)2.15128423
93Retinal dysplasia (HP:0007973)2.15012560
94Clumsiness (HP:0002312)2.14516444
95Tubular atrophy (HP:0000092)2.14500040
96Chronic hepatic failure (HP:0100626)2.14459087
97Ectopic kidney (HP:0000086)2.14208686
98Amelogenesis imperfecta (HP:0000705)2.12391854
99Abnormality of alanine metabolism (HP:0010916)2.11984678
100Hyperalaninemia (HP:0003348)2.11984678
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11984678
102Mitochondrial inheritance (HP:0001427)2.10767739
103Cerebellar dysplasia (HP:0007033)2.10006854
104Pendular nystagmus (HP:0012043)2.09814871
105Facial cleft (HP:0002006)2.08325562
106Spinal muscular atrophy (HP:0007269)2.08036263
107Preauricular skin tag (HP:0000384)2.07785356
108Pulmonary fibrosis (HP:0002206)2.07721738
109Intestinal atresia (HP:0011100)2.07548651
110Methylmalonic acidemia (HP:0002912)2.07383892
111Muscle fibrillation (HP:0010546)2.06425679
112Opisthotonus (HP:0002179)2.05918692
113Pachygyria (HP:0001302)2.05635524
114Congenital hepatic fibrosis (HP:0002612)2.04655299
115Hypoplasia of the pons (HP:0012110)2.04611696
116Neoplasm of the colon (HP:0100273)2.04279190
117Furrowed tongue (HP:0000221)2.04233605
118Abnormality of chromosome stability (HP:0003220)2.03236754
119Disproportionate short-trunk short stature (HP:0003521)2.03120930
120Absent speech (HP:0001344)2.03076738
121High pitched voice (HP:0001620)2.02973284
122Abnormal protein glycosylation (HP:0012346)2.02649449
123Abnormal glycosylation (HP:0012345)2.02649449
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02649449
125Abnormal protein N-linked glycosylation (HP:0012347)2.02649449
126Abnormality of the preputium (HP:0100587)2.02494196
127Microvesicular hepatic steatosis (HP:0001414)2.02321195
128Skin tags (HP:0010609)2.02183246
12911 pairs of ribs (HP:0000878)2.02126799
130Hepatic necrosis (HP:0002605)2.00844972
131Ketosis (HP:0001946)2.00412191
132Acute necrotizing encephalopathy (HP:0006965)1.99671583
133Methylmalonic aciduria (HP:0012120)1.99096944
134Type I transferrin isoform profile (HP:0003642)1.98251163
135Male pseudohermaphroditism (HP:0000037)1.97929896
136Polyuria (HP:0000103)1.97326438
137Pancreatic fibrosis (HP:0100732)1.96810090
138Fair hair (HP:0002286)1.96161186
139Optic neuritis (HP:0100653)1.95548113
140Retrobulbar optic neuritis (HP:0100654)1.95548113
141Breast aplasia (HP:0100783)1.95262770
142Abnormal lung lobation (HP:0002101)1.94615107
143Absent forearm bone (HP:0003953)1.94525256
144Aplasia involving forearm bones (HP:0009822)1.94525256
145Anencephaly (HP:0002323)1.94168664
146Cellular immunodeficiency (HP:0005374)1.92222212
147Prominent metopic ridge (HP:0005487)1.91692522
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.91542638
149Abnormality of the umbilical cord (HP:0010881)1.91395024
150Petechiae (HP:0000967)1.90694844
151Proximal placement of thumb (HP:0009623)1.89647660
152Abnormality of lateral ventricle (HP:0030047)1.89469591
153Aplasia/Hypoplasia of the breasts (HP:0010311)1.89358933
154Microretrognathia (HP:0000308)1.89072354
155Severe muscular hypotonia (HP:0006829)1.88880610
156Gait imbalance (HP:0002141)1.88390439
157Decreased central vision (HP:0007663)1.88250151
158Optic disc pallor (HP:0000543)1.88189091
159Constricted visual fields (HP:0001133)1.88103256
160Deviation of the thumb (HP:0009603)1.87892214
161Short palpebral fissure (HP:0012745)1.87672686
162Absent thumb (HP:0009777)1.87653785
163Congenital primary aphakia (HP:0007707)1.87282271
164Protruding tongue (HP:0010808)1.85938920
165Small intestinal stenosis (HP:0012848)1.85842265
166Duodenal stenosis (HP:0100867)1.85842265
167Abnormal trabecular bone morphology (HP:0100671)1.85551062
168Ketoacidosis (HP:0001993)1.85466279
169Abnormality of the columella (HP:0009929)1.85451164
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.84885037
171Abnormality of the fingertips (HP:0001211)1.84871414
172Progressive microcephaly (HP:0000253)1.84540680
173Febrile seizures (HP:0002373)1.84487651
174Secondary amenorrhea (HP:0000869)1.84422836
175Decreased circulating renin level (HP:0003351)1.84323947
176Congenital sensorineural hearing impairment (HP:0008527)1.84265426
177Acute encephalopathy (HP:0006846)1.84092333
178Biliary tract neoplasm (HP:0100574)1.83198939
179Progressive macrocephaly (HP:0004481)1.82562424
180Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82044144
181Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79117568
182Short 4th metacarpal (HP:0010044)1.79117568
183Atonic seizures (HP:0010819)1.78901071
184Personality changes (HP:0000751)1.78476560
185Nephrogenic diabetes insipidus (HP:0009806)1.78399194
186Freckling (HP:0001480)1.78067273
187Atresia of the external auditory canal (HP:0000413)1.77928939
1883-Methylglutaconic aciduria (HP:0003535)1.77244279
189Asplenia (HP:0001746)1.76562069
190Renal cortical cysts (HP:0000803)1.75887976
191Broad-based gait (HP:0002136)1.75005684
192Thyroiditis (HP:0100646)1.74209456
193Severe combined immunodeficiency (HP:0004430)1.72777126
194Bony spicule pigmentary retinopathy (HP:0007737)1.71619303
195Retinitis pigmentosa (HP:0000510)1.71253519
196Increased corneal curvature (HP:0100692)1.69359371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.08617175
2TSSK64.20857537
3SRPK14.16705214
4BUB14.10937200
5WEE13.76920395
6CDC73.56929368
7BMPR1B3.54449730
8PINK13.24042246
9TAOK33.06364978
10MAP4K22.99599352
11MUSK2.96500930
12TESK22.91171884
13EIF2AK12.86752396
14PASK2.74501685
15ADRBK22.54683349
16PLK42.54033133
17PRKD32.53196274
18NEK22.34000478
19NUAK12.30775484
20ACVR1B2.16440099
21WNK32.15634588
22MAPK132.12617935
23NEK12.12349879
24TRIM281.97328411
25GRK11.85156511
26CDK71.82750203
27ATR1.81728683
28TTK1.77308588
29CASK1.77164701
30PLK31.70539967
31MELK1.70127274
32PLK11.62979656
33CDK121.55720134
34WNK41.54130370
35TESK11.50434604
36INSRR1.50236306
37BRSK11.47445842
38EIF2AK31.46660091
39CDK81.46071521
40VRK11.45368132
41MKNK11.40690320
42CHEK21.40368088
43AURKA1.38995712
44PNCK1.33294115
45TLK11.30611985
46PDK31.28852527
47PDK41.28852527
48AURKB1.23128914
49IKBKB1.18003044
50MAP3K41.16541054
51MAP2K71.15167815
52NME21.15129371
53DAPK21.15121193
54CHEK11.14541938
55CAMKK21.14175339
56TNK21.13467893
57DYRK31.13248232
58CCNB11.12974085
59BRSK21.09110549
60PAK31.07493737
61MAP2K61.06941056
62AKT31.06939229
63CDK40.98658395
64PKN10.97025720
65EEF2K0.96260057
66MARK30.95594273
67OXSR10.94570394
68PHKG20.94317286
69PHKG10.94317286
70PAK40.94004966
71RPS6KA40.93537539
72GRK60.91982540
73ATM0.91029728
74STK390.90944954
75ADRBK10.90716571
76CDK20.89288422
77PIM10.87549983
78MKNK20.85786717
79IRAK10.85431549
80PRKCQ0.84460456
81RPS6KB20.83968925
82SCYL20.83158736
83TGFBR10.82625124
84VRK20.81325831
85BRAF0.80755172
86SIK20.79657492
87MAP3K80.77074817
88STK160.76811291
89SYK0.76553440
90KIT0.75018478
91FLT30.72665055
92MAPKAPK30.72358857
93BCKDK0.70568351
94MAPK150.70363745
95CSNK2A20.69390154
96BRD40.69107733
97LATS20.67757180
98STK100.67517192
99PAK10.66292522
100TXK0.65827757
101PLK20.65243551
102PTK2B0.65103525
103CDK10.64044057
104PRKCE0.63854355
105OBSCN0.63776366
106EPHA20.62939804
107MAP3K140.61167003
108TAF10.61055590
109LATS10.60949605
110IKBKE0.59819923
111CSNK2A10.57590922
112ZAK0.57089614
113CHUK0.55214541
114CSNK1A1L0.54543746
115MAP2K20.53247186
116PRKD20.52912504
117ALK0.52629076
118RPS6KA50.52112452
119FGFR10.51031460
120LIMK10.50167652
121LCK0.48669054
122MST40.48464535
123PRKCG0.48424223
124MAP4K10.48287296
125GRK70.47673300
126LYN0.46761479
127TEC0.46540645
128CSNK1E0.46380925
129BCR0.46089602
130ITK0.45569690
131MAP3K110.45412250
132PKN20.44440032
133STK40.44184679
134IRAK40.43652529
135PRKCI0.43569828
136GRK50.42834010
137CSNK1G30.42799986
138DYRK20.42545440
139MAP3K50.41248342
140STK38L0.41213399
141TAOK10.40405633
142SIK30.40004293
143CDK190.39812644
144PAK60.39259895
145STK110.39115396
146PIK3CG0.38257698
147MTOR0.38144636
148STK30.37816234
149PIM20.37523716
150ZAP700.37400270
151CSNK1A10.36228789
152PRKAA20.36151507
153PRKCZ0.35110819
154CAMK10.34384148
155EPHA30.33974574
156CSNK1G20.33016623
157RPS6KB10.32019938
158TYK20.31240174
159PRKDC0.30985653
160PRKACA0.30505076
161BLK0.30480436
162CDK30.29840148
163BTK0.29758376
164CSNK1D0.29398290
165PRKAA10.29352499
166MAPKAPK50.29102916
167AKT20.26693245
168MAPKAPK20.26337296
169CSNK1G10.24636254
170STK240.23100965
171ILK0.22333332
172DAPK10.20997770
173PDK20.20893421
174ERBB30.20847285
175GSK3B0.20801241
176MAPK110.20453044

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83814375
2Mismatch repair_Homo sapiens_hsa034304.72158023
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.83675236
4Spliceosome_Homo sapiens_hsa030403.33042846
5RNA transport_Homo sapiens_hsa030133.32135230
6Phototransduction_Homo sapiens_hsa047443.30510922
7RNA polymerase_Homo sapiens_hsa030203.19931540
8Nitrogen metabolism_Homo sapiens_hsa009103.12529968
9Nucleotide excision repair_Homo sapiens_hsa034203.11677976
10Proteasome_Homo sapiens_hsa030503.09833439
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95302759
12Base excision repair_Homo sapiens_hsa034102.94245468
13One carbon pool by folate_Homo sapiens_hsa006702.93463828
14Homologous recombination_Homo sapiens_hsa034402.90291277
15Cell cycle_Homo sapiens_hsa041102.86945145
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69104339
17Ribosome_Homo sapiens_hsa030102.47719681
18Pyrimidine metabolism_Homo sapiens_hsa002402.36737966
19Butanoate metabolism_Homo sapiens_hsa006502.36568924
20Linoleic acid metabolism_Homo sapiens_hsa005912.32976824
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31083870
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23361890
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22593218
24Maturity onset diabetes of the young_Homo sapiens_hsa049502.22488760
25Basal transcription factors_Homo sapiens_hsa030222.17348896
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10181718
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.02433482
28RNA degradation_Homo sapiens_hsa030181.97314828
29Fanconi anemia pathway_Homo sapiens_hsa034601.96751040
30mRNA surveillance pathway_Homo sapiens_hsa030151.89557981
31Ether lipid metabolism_Homo sapiens_hsa005651.85027509
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80638446
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.76911153
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.64611115
35Peroxisome_Homo sapiens_hsa041461.61569751
36Oxidative phosphorylation_Homo sapiens_hsa001901.60414739
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55928375
38p53 signaling pathway_Homo sapiens_hsa041151.50556555
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.47882528
40Tryptophan metabolism_Homo sapiens_hsa003801.47737855
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40501220
42Vitamin B6 metabolism_Homo sapiens_hsa007501.38304318
43Biosynthesis of amino acids_Homo sapiens_hsa012301.37394259
44Collecting duct acid secretion_Homo sapiens_hsa049661.35146907
45Protein export_Homo sapiens_hsa030601.34334976
46Non-homologous end-joining_Homo sapiens_hsa034501.30839267
47Folate biosynthesis_Homo sapiens_hsa007901.25913230
48Purine metabolism_Homo sapiens_hsa002301.25423572
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24485590
50Parkinsons disease_Homo sapiens_hsa050121.23017882
51Propanoate metabolism_Homo sapiens_hsa006401.22661100
52Pentose phosphate pathway_Homo sapiens_hsa000301.20939523
53Selenocompound metabolism_Homo sapiens_hsa004501.20747073
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18999088
55Olfactory transduction_Homo sapiens_hsa047401.18959358
56Epstein-Barr virus infection_Homo sapiens_hsa051691.16298841
57Arachidonic acid metabolism_Homo sapiens_hsa005901.10979131
58Oocyte meiosis_Homo sapiens_hsa041141.10638174
59Dorso-ventral axis formation_Homo sapiens_hsa043201.06564866
60Sulfur relay system_Homo sapiens_hsa041221.05034851
61Antigen processing and presentation_Homo sapiens_hsa046121.03993191
62ABC transporters_Homo sapiens_hsa020101.03854332
63Type I diabetes mellitus_Homo sapiens_hsa049401.03201698
64Nicotine addiction_Homo sapiens_hsa050331.01809805
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00192529
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99193732
67beta-Alanine metabolism_Homo sapiens_hsa004100.98718391
68Graft-versus-host disease_Homo sapiens_hsa053320.96953560
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96703708
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89980958
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.88941241
72Systemic lupus erythematosus_Homo sapiens_hsa053220.88527553
73* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87826035
74Carbon metabolism_Homo sapiens_hsa012000.87714501
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87626975
76Morphine addiction_Homo sapiens_hsa050320.87407798
77Caffeine metabolism_Homo sapiens_hsa002320.87078078
78Taste transduction_Homo sapiens_hsa047420.85975855
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85254738
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.84042335
81Autoimmune thyroid disease_Homo sapiens_hsa053200.82801168
82Circadian rhythm_Homo sapiens_hsa047100.82507325
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81939343
84Herpes simplex infection_Homo sapiens_hsa051680.81852243
85Asthma_Homo sapiens_hsa053100.81823638
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81653714
87Viral carcinogenesis_Homo sapiens_hsa052030.79620949
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77377875
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.76280288
90Circadian entrainment_Homo sapiens_hsa047130.75941931
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74994251
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.74981472
93Rheumatoid arthritis_Homo sapiens_hsa053230.73225216
94Legionellosis_Homo sapiens_hsa051340.71374505
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68643983
96Insulin secretion_Homo sapiens_hsa049110.68338095
97Glycerolipid metabolism_Homo sapiens_hsa005610.68247084
98Serotonergic synapse_Homo sapiens_hsa047260.66701184
99Ovarian steroidogenesis_Homo sapiens_hsa049130.64808450
100Salivary secretion_Homo sapiens_hsa049700.64774340
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.64327656
102HTLV-I infection_Homo sapiens_hsa051660.63219404
103Hematopoietic cell lineage_Homo sapiens_hsa046400.62186950
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61568712
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61224623
106Alzheimers disease_Homo sapiens_hsa050100.61008974
107Notch signaling pathway_Homo sapiens_hsa043300.60734014
108Calcium signaling pathway_Homo sapiens_hsa040200.59723656
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59146938
110Fructose and mannose metabolism_Homo sapiens_hsa000510.58505795
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57933145
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.56912381
113MicroRNAs in cancer_Homo sapiens_hsa052060.55745029
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53452759
115Fatty acid metabolism_Homo sapiens_hsa012120.53177321
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49630672
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.49154305
118Sulfur metabolism_Homo sapiens_hsa009200.48317792
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47221507
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44998201
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.44876582
122Steroid biosynthesis_Homo sapiens_hsa001000.44630185
123Shigellosis_Homo sapiens_hsa051310.44184515
124GABAergic synapse_Homo sapiens_hsa047270.43009342
125Fatty acid degradation_Homo sapiens_hsa000710.40479867
126Type II diabetes mellitus_Homo sapiens_hsa049300.40317732
127Chemical carcinogenesis_Homo sapiens_hsa052040.38992098
128Primary immunodeficiency_Homo sapiens_hsa053400.37115713
129Glutathione metabolism_Homo sapiens_hsa004800.36749039
130Pyruvate metabolism_Homo sapiens_hsa006200.36593997
131Hepatitis B_Homo sapiens_hsa051610.36389219
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36236093
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.34481926
134African trypanosomiasis_Homo sapiens_hsa051430.30737799
135Cardiac muscle contraction_Homo sapiens_hsa042600.30682096
136Huntingtons disease_Homo sapiens_hsa050160.29508759
137Mineral absorption_Homo sapiens_hsa049780.28786946
138Oxytocin signaling pathway_Homo sapiens_hsa049210.28667291
139Glutamatergic synapse_Homo sapiens_hsa047240.27769607
140Lysine degradation_Homo sapiens_hsa003100.27132980
141Basal cell carcinoma_Homo sapiens_hsa052170.27039622
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26890663
143Colorectal cancer_Homo sapiens_hsa052100.26033529
144Hippo signaling pathway_Homo sapiens_hsa043900.25920174
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24308944
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23734942
147Metabolic pathways_Homo sapiens_hsa011000.23230327
148Alcoholism_Homo sapiens_hsa050340.21959634
149Regulation of autophagy_Homo sapiens_hsa041400.21659868
150Galactose metabolism_Homo sapiens_hsa000520.21199725
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19721717
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19677540
153Viral myocarditis_Homo sapiens_hsa054160.19497968
154N-Glycan biosynthesis_Homo sapiens_hsa005100.18937087
155Thyroid cancer_Homo sapiens_hsa052160.18786017
156mTOR signaling pathway_Homo sapiens_hsa041500.17461280
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.16642004
158Arginine and proline metabolism_Homo sapiens_hsa003300.16550513
159Chronic myeloid leukemia_Homo sapiens_hsa052200.16480147
160Apoptosis_Homo sapiens_hsa042100.15883838
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15880601
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15722222
163HIF-1 signaling pathway_Homo sapiens_hsa040660.13478288
164Allograft rejection_Homo sapiens_hsa053300.11741382
165Bladder cancer_Homo sapiens_hsa052190.11315078
166Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.09320084
167Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.07782652
168Glucagon signaling pathway_Homo sapiens_hsa049220.07772631
169Measles_Homo sapiens_hsa051620.07091433
170TGF-beta signaling pathway_Homo sapiens_hsa043500.06743630
171Influenza A_Homo sapiens_hsa051640.06662396
172Vitamin digestion and absorption_Homo sapiens_hsa049770.06451537
173Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05672509
174Small cell lung cancer_Homo sapiens_hsa052220.05076621
175Hedgehog signaling pathway_Homo sapiens_hsa043400.04840958
176Neurotrophin signaling pathway_Homo sapiens_hsa047220.03109924

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