UBQLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.14197877
2nuclear pore organization (GO:0006999)5.13977827
3alpha-linolenic acid metabolic process (GO:0036109)4.70569869
4L-phenylalanine catabolic process (GO:0006559)4.60173535
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.60173535
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.40815527
7L-phenylalanine metabolic process (GO:0006558)4.40815527
8pore complex assembly (GO:0046931)4.36922297
9regulation of NFAT protein import into nucleus (GO:0051532)4.33098489
10cysteine metabolic process (GO:0006534)4.30850750
11regulation of RNA export from nucleus (GO:0046831)4.14319997
12lysine catabolic process (GO:0006554)4.06188666
13lysine metabolic process (GO:0006553)4.06188666
14regulation of nucleobase-containing compound transport (GO:0032239)3.94407631
15mitotic chromosome condensation (GO:0007076)3.94195538
16sulfur amino acid catabolic process (GO:0000098)3.84748769
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.78913021
18regulation of cholesterol homeostasis (GO:2000188)3.76934671
19urea metabolic process (GO:0019627)3.70552197
20urea cycle (GO:0000050)3.70552197
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70035408
22DNA unwinding involved in DNA replication (GO:0006268)3.68207124
23negative regulation of fibrinolysis (GO:0051918)3.62956340
24embryonic process involved in female pregnancy (GO:0060136)3.62433563
25dicarboxylic acid biosynthetic process (GO:0043650)3.62341642
26glutamate metabolic process (GO:0006536)3.61123430
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.57692163
28regulation of translational termination (GO:0006449)3.52580374
29aromatic amino acid family catabolic process (GO:0009074)3.52566304
30cell-substrate adherens junction assembly (GO:0007045)3.45395938
31focal adhesion assembly (GO:0048041)3.45395938
32serine family amino acid catabolic process (GO:0009071)3.44689967
33adherens junction assembly (GO:0034333)3.44499347
34protein retention in ER lumen (GO:0006621)3.43061775
35vesicle coating (GO:0006901)3.42407125
36glyoxylate metabolic process (GO:0046487)3.38876418
37regulation of fatty acid beta-oxidation (GO:0031998)3.38553169
38bile acid biosynthetic process (GO:0006699)3.37509197
39nitrogen cycle metabolic process (GO:0071941)3.29621493
40kynurenine metabolic process (GO:0070189)3.29360420
41low-density lipoprotein particle clearance (GO:0034383)3.27905398
42layer formation in cerebral cortex (GO:0021819)3.27618484
43negative regulation of cholesterol transport (GO:0032375)3.25602553
44negative regulation of sterol transport (GO:0032372)3.25602553
45glucocorticoid receptor signaling pathway (GO:0042921)3.25182584
46acetyl-CoA metabolic process (GO:0006084)3.24803477
47cell-substrate junction assembly (GO:0007044)3.23525152
48complement activation, alternative pathway (GO:0006957)3.23394139
49RNA stabilization (GO:0043489)3.21652099
50mRNA stabilization (GO:0048255)3.21652099
51regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.20873502
52positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.20873502
53aspartate family amino acid catabolic process (GO:0009068)3.19516866
54synaptic vesicle maturation (GO:0016188)3.16286901
55activation of Rac GTPase activity (GO:0032863)3.14806646
56glycine metabolic process (GO:0006544)3.13823518
57serine family amino acid metabolic process (GO:0009069)3.13678367
58cellular protein complex localization (GO:0034629)3.13644125
59mitotic sister chromatid cohesion (GO:0007064)3.13432924
60protein localization to endosome (GO:0036010)3.13213730
61cellular modified amino acid catabolic process (GO:0042219)3.13112285
62dosage compensation (GO:0007549)3.12026230
63spliceosomal tri-snRNP complex assembly (GO:0000244)3.11695162
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.11545208
65protein localization to microtubule (GO:0035372)3.08198513
66positive regulation of fatty acid beta-oxidation (GO:0032000)3.07932194
67positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.07662021
68cellular ketone body metabolic process (GO:0046950)3.07230950
69acylglycerol catabolic process (GO:0046464)3.06496847
70neutral lipid catabolic process (GO:0046461)3.06496847
71regulation of protein activation cascade (GO:2000257)3.05564907
722-oxoglutarate metabolic process (GO:0006103)3.04998602
73plasma lipoprotein particle clearance (GO:0034381)3.03453851
74homocysteine metabolic process (GO:0050667)3.01606864
75serine family amino acid biosynthetic process (GO:0009070)2.99784224
76peptidyl-lysine dimethylation (GO:0018027)2.99631318
77fatty-acyl-CoA biosynthetic process (GO:0046949)2.98425596
78regulation of clathrin-mediated endocytosis (GO:2000369)2.97781371
79paraxial mesoderm development (GO:0048339)2.96190461
80protein export from nucleus (GO:0006611)2.95809642
81fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.95417772
82high-density lipoprotein particle remodeling (GO:0034375)2.93985273
83regulation of fibrinolysis (GO:0051917)2.92911054
84hemidesmosome assembly (GO:0031581)2.92239653
85regulation of histone H3-K27 methylation (GO:0061085)2.91249182
863-UTR-mediated mRNA stabilization (GO:0070935)2.90544147
87histone H3-K9 demethylation (GO:0033169)2.90199317
88protein carboxylation (GO:0018214)2.89805039
89peptidyl-glutamic acid carboxylation (GO:0017187)2.89805039
90regulation of complement activation (GO:0030449)2.88639142
91triglyceride catabolic process (GO:0019433)2.87316362
92Golgi transport vesicle coating (GO:0048200)2.87161942
93COPI coating of Golgi vesicle (GO:0048205)2.87161942
94positive regulation of lipid catabolic process (GO:0050996)2.87055551
95long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.86955539
96acyl-CoA biosynthetic process (GO:0071616)2.85950088
97thioester biosynthetic process (GO:0035384)2.85950088
98bile acid metabolic process (GO:0008206)2.84024420
99peptidyl-threonine modification (GO:0018210)2.83086183
100alpha-amino acid catabolic process (GO:1901606)2.82959964
101cytoplasmic mRNA processing body assembly (GO:0033962)2.81491058
102ethanol oxidation (GO:0006069)2.80900044
103pyrimidine nucleobase catabolic process (GO:0006208)2.80592932
104locomotory exploration behavior (GO:0035641)2.80291207
105amino-acid betaine metabolic process (GO:0006577)2.79327111
106fatty acid homeostasis (GO:0055089)2.78040278
107cellular amino acid catabolic process (GO:0009063)2.77907469
108regulation of triglyceride catabolic process (GO:0010896)2.75360384
109regulation of ARF protein signal transduction (GO:0032012)2.75326969
110COPII vesicle coating (GO:0048208)2.74640017
111acylglycerol homeostasis (GO:0055090)2.73497325
112triglyceride homeostasis (GO:0070328)2.73497325
113regulation of glucose import in response to insulin stimulus (GO:2001273)2.73418933
114histone H3-K36 demethylation (GO:0070544)2.72585152
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.71515985
116corticosteroid receptor signaling pathway (GO:0031958)2.71440459
117peptidyl-threonine phosphorylation (GO:0018107)2.71154027
118drug catabolic process (GO:0042737)2.71079754
119hypotonic response (GO:0006971)2.70113779
120protein localization to chromosome, centromeric region (GO:0071459)2.69433911
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69271643
122histone lysine demethylation (GO:0070076)2.68877246
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66607503
124protein complex localization (GO:0031503)2.66550211
125skin morphogenesis (GO:0043589)2.65560599
126cell adhesion mediated by integrin (GO:0033627)2.65362773
127cortical actin cytoskeleton organization (GO:0030866)2.64789337
128stress granule assembly (GO:0034063)2.64404753
129dicarboxylic acid catabolic process (GO:0043649)2.64151614
130sodium ion export (GO:0071436)2.63813059
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63652278
132nucleobase catabolic process (GO:0046113)2.63531390
133negative regulation of lipid transport (GO:0032369)2.62586139
134epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61943889
135regulation of mitotic spindle organization (GO:0060236)2.61834795
136regulation of cholesterol biosynthetic process (GO:0045540)2.61638453
137CDP-diacylglycerol metabolic process (GO:0046341)2.61285550
138ketone body metabolic process (GO:1902224)2.60317214
139reverse cholesterol transport (GO:0043691)2.59967948
140one-carbon metabolic process (GO:0006730)2.58651322
141triglyceride metabolic process (GO:0006641)2.57270747
142tryptophan catabolic process (GO:0006569)2.57237132
143indole-containing compound catabolic process (GO:0042436)2.57237132
144indolalkylamine catabolic process (GO:0046218)2.57237132
145histone demethylation (GO:0016577)2.57058142
146CDP-diacylglycerol biosynthetic process (GO:0016024)2.56057727
147stress fiber assembly (GO:0043149)2.54957407
148negative regulation of cell size (GO:0045792)2.54904674
149clathrin coat assembly (GO:0048268)2.53837663
150acylglycerol metabolic process (GO:0006639)2.53740827
151short-chain fatty acid metabolic process (GO:0046459)2.53463078
152pre-miRNA processing (GO:0031054)2.52324589
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.51746588
154tricarboxylic acid metabolic process (GO:0072350)2.51194312
155regulation of early endosome to late endosome transport (GO:2000641)2.50641252
156neutral lipid metabolic process (GO:0006638)2.50475355
157cellular glucuronidation (GO:0052695)2.50445852
158fatty acid transmembrane transport (GO:1902001)2.49639967
159glutamate secretion (GO:0014047)2.48820356
160positive regulation of fatty acid oxidation (GO:0046321)2.48257662
161triglyceride biosynthetic process (GO:0019432)2.48193599
162positive regulation of protein export from nucleus (GO:0046827)2.47482590
163localization within membrane (GO:0051668)2.47422433
164positive regulation of nuclease activity (GO:0032075)2.46409922
165regulation of translational fidelity (GO:0006450)2.46337611
166regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.46047975
167heterochromatin organization (GO:0070828)2.43649191
168ER-nucleus signaling pathway (GO:0006984)2.43454896
169regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.43095641
170NLS-bearing protein import into nucleus (GO:0006607)2.42564174
171endoplasmic reticulum unfolded protein response (GO:0030968)2.41198974
172response to laminar fluid shear stress (GO:0034616)2.38991707
173negative regulation of fatty acid transport (GO:2000192)2.38491079
174receptor recycling (GO:0001881)2.37151821
175protein targeting to plasma membrane (GO:0072661)2.34639101
176regulation of sister chromatid cohesion (GO:0007063)2.34346039
177negative regulation of histone methylation (GO:0031061)2.32973825
178desmosome organization (GO:0002934)2.29708603
179epithelial cell-cell adhesion (GO:0090136)2.28964220
180mating behavior (GO:0007617)2.27124966
181insulin-like growth factor receptor signaling pathway (GO:0048009)2.26466016
182positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25926483
183negative regulation of anoikis (GO:2000811)2.24022159
184cellular response to unfolded protein (GO:0034620)2.23377259
185histone H2B ubiquitination (GO:0033523)2.23252510
186protein demethylation (GO:0006482)2.22676073
187protein dealkylation (GO:0008214)2.22676073
188positive regulation of cellular response to insulin stimulus (GO:1900078)2.21460140
189regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.20712869
190cytoskeleton-dependent cytokinesis (GO:0061640)2.20422918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.20476358
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.33371873
3E2F7_22180533_ChIP-Seq_HELA_Human4.30397623
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.03056262
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.95394480
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.57674238
7ZNF263_19887448_ChIP-Seq_K562_Human3.42048630
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16921774
9CLOCK_20551151_ChIP-Seq_293T_Human2.96518812
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.39249738
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29956043
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28828451
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19863695
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03026619
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00490948
16ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99279517
17* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.91190191
18* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.89530482
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.88803058
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83483718
21ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82766086
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78483811
23* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.76343665
24KDM2B_26808549_Chip-Seq_DND41_Human1.70296402
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65842654
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65781160
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65548893
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.64506235
29MYC_22102868_ChIP-Seq_BL_Human1.63653689
30KDM2B_26808549_Chip-Seq_K562_Human1.63335509
31* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62909172
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.61706478
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61670322
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61639787
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61391302
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59885842
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56508133
38* ATF3_27146783_Chip-Seq_COLON_Human1.55353621
39* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54872356
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.53834557
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53630168
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52822684
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51635818
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51566303
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.50184919
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48296681
47RACK7_27058665_Chip-Seq_MCF-7_Human1.46851617
48CREB1_26743006_Chip-Seq_LNCaP_Human1.45939426
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42768673
50LXR_22292898_ChIP-Seq_THP-1_Human1.42557089
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42125415
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40806333
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40585753
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40176403
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39652438
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.39299890
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.37402546
58* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36574790
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.35740355
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34427016
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34081557
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33856370
63TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32233842
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31206053
65* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30842441
66* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30842441
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30804299
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30481933
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30419778
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30045472
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28840832
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28045736
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27781364
74GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.27778019
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27224385
76VDR_21846776_ChIP-Seq_THP-1_Human1.27219916
77* WT1_19549856_ChIP-ChIP_CCG9911_Human1.27140010
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26104842
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25305234
80AR_21909140_ChIP-Seq_LNCAP_Human1.24376735
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23738438
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.23415019
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22562085
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.19834813
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18780946
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17650100
87* KDM2B_26808549_Chip-Seq_JURKAT_Human1.17360218
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17246054
89NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16743144
90* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15675847
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15538828
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13881760
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13494734
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13305793
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13047306
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13022138
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12396022
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12248894
99* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11975215
100* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11116664
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10785244
102TFEB_21752829_ChIP-Seq_HELA_Human1.10745528
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10480262
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10321081
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.10055589
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10033228
107TCF7_22412390_ChIP-Seq_EML_Mouse1.09576495
108* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08054771
109RUNX1_27514584_Chip-Seq_MCF-7_Human1.07370607
110GATA6_25053715_ChIP-Seq_YYC3_Human1.06791349
111CHD1_26751641_Chip-Seq_LNCaP_Human1.05458667
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04907918
113SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04746399
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03877503
115* HNF4A_19822575_ChIP-Seq_HepG2_Human1.03375617
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02602978
117* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02461579
118PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01436351
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01406120
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00585507
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99465813
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98439205
123* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97994734
124NCOR1_26117541_ChIP-Seq_K562_Human0.97241604
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.97169280
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92865268
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.90331099
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.90331099
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90222743
130GATA1_19941826_ChIP-Seq_K562_Human0.88863211
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88110128
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87280443
133P68_20966046_ChIP-Seq_HELA_Human0.86831915
134FOXM1_23109430_ChIP-Seq_U2OS_Human0.86636068
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86513309
136SMC4_20622854_ChIP-Seq_HELA_Human0.84739822
137TP53_22127205_ChIP-Seq_IMR90_Human0.84144303
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82428301
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.81467463
140REST_18959480_ChIP-ChIP_MESCs_Mouse0.79349957
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79077213
142NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78886865
143DROSHA_22980978_ChIP-Seq_HELA_Human0.78285815
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77439970
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77359073
146KLF4_19829295_ChIP-Seq_ESCs_Human0.76140604
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75903118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.99820667
2MP0005360_urolithiasis4.84148518
3MP0010234_abnormal_vibrissa_follicle4.51249553
4MP0003705_abnormal_hypodermis_morpholog3.96754219
5MP0005085_abnormal_gallbladder_physiolo3.65991174
6MP0005365_abnormal_bile_salt3.54611713
7MP0004859_abnormal_synaptic_plasticity2.80027161
8MP0002009_preneoplasia2.71068797
9MP0003329_amyloid_beta_deposits2.63514367
10MP0010329_abnormal_lipoprotein_level2.62802133
11MP0008875_abnormal_xenobiotic_pharmacok2.62664092
12MP0003806_abnormal_nucleotide_metabolis2.60641199
13MP0005409_darkened_coat_color2.55435846
14MP0005083_abnormal_biliary_tract2.35109945
15MP0003252_abnormal_bile_duct2.30991312
16MP0009840_abnormal_foam_cell2.28373750
17MP0004185_abnormal_adipocyte_glucose2.00789533
18MP0000604_amyloidosis1.92134596
19MP0001666_abnormal_nutrient_absorption1.91899992
20MP0010352_gastrointestinal_tract_polyps1.91498622
21MP0008057_abnormal_DNA_replication1.83717389
22MP0005332_abnormal_amino_acid1.79523426
23MP0008260_abnormal_autophagy1.78243801
24MP0004270_analgesia1.73415541
25MP0009780_abnormal_chondrocyte_physiolo1.71178940
26MP0002118_abnormal_lipid_homeostasis1.67328407
27MP0004130_abnormal_muscle_cell1.66127295
28MP0008438_abnormal_cutaneous_collagen1.64226908
29MP0000537_abnormal_urethra_morphology1.61178782
30MP0004957_abnormal_blastocyst_morpholog1.60592290
31MP0003111_abnormal_nucleus_morphology1.58424551
32MP0005076_abnormal_cell_differentiation1.55872869
33MP0000609_abnormal_liver_physiology1.55571671
34MP0002796_impaired_skin_barrier1.53535559
35MP0000350_abnormal_cell_proliferation1.53243157
36MP0002909_abnormal_adrenal_gland1.49198788
37MP0000733_abnormal_muscle_development1.48389648
38MP0005666_abnormal_adipose_tissue1.46875638
39MP0005257_abnormal_intraocular_pressure1.44432832
40MP0004858_abnormal_nervous_system1.43753577
41MP0003191_abnormal_cellular_cholesterol1.43533265
42MP0009053_abnormal_anal_canal1.40192211
43MP0003656_abnormal_erythrocyte_physiolo1.39488888
44MP0001849_ear_inflammation1.37578682
45MP0001915_intracranial_hemorrhage1.36677443
46MP0005380_embryogenesis_phenotype1.36671642
47MP0001672_abnormal_embryogenesis/_devel1.36671642
48MP0008961_abnormal_basal_metabolism1.36426798
49MP0002060_abnormal_skin_morphology1.34145162
50MP0005621_abnormal_cell_physiology1.33603663
51MP0003984_embryonic_growth_retardation1.30979028
52MP0004885_abnormal_endolymph1.30929719
53MP0003077_abnormal_cell_cycle1.27917083
54MP0003941_abnormal_skin_development1.26785540
55MP0002086_abnormal_extraembryonic_tissu1.26199320
56MP0003300_gastrointestinal_ulcer1.25903938
57MP0005375_adipose_tissue_phenotype1.24445581
58MP0003635_abnormal_synaptic_transmissio1.24224938
59MP0002088_abnormal_embryonic_growth/wei1.23017821
60MP0002080_prenatal_lethality1.19679574
61MP0003195_calcinosis1.14387186
62MP0000003_abnormal_adipose_tissue1.13982002
63MP0008932_abnormal_embryonic_tissue1.13660019
64MP0005584_abnormal_enzyme/coenzyme_acti1.12906575
65MP0003115_abnormal_respiratory_system1.10249159
66MP0005187_abnormal_penis_morphology1.09415055
67MP0004087_abnormal_muscle_fiber1.08003902
68MP0000579_abnormal_nail_morphology1.07736268
69MP0004264_abnormal_extraembryonic_tissu1.07563887
70MP0010630_abnormal_cardiac_muscle1.06165086
71MP0004782_abnormal_surfactant_physiolog1.06021827
72MP0000013_abnormal_adipose_tissue1.05467925
73MP0001697_abnormal_embryo_size1.05383740
74MP0004808_abnormal_hematopoietic_stem1.04268556
75MP0009672_abnormal_birth_weight1.04212410
76MP0004272_abnormal_basement_membrane1.04111229
77MP0003690_abnormal_glial_cell1.03872627
78MP0002089_abnormal_postnatal_growth/wei1.03662119
79MP0000759_abnormal_skeletal_muscle1.03071944
80MP0000428_abnormal_craniofacial_morphol1.02043624
81MP0005058_abnormal_lysosome_morphology1.01953133
82MP0004233_abnormal_muscle_weight1.00857070
83MP0005384_cellular_phenotype1.00836993
84MP0003868_abnormal_feces_composition1.00780780
85MP0001730_embryonic_growth_arrest0.99666609
86MP0001216_abnormal_epidermal_layer0.99659999
87MP0005319_abnormal_enzyme/_coenzyme0.99154664
88MP0002877_abnormal_melanocyte_morpholog0.98114899
89MP0003283_abnormal_digestive_organ0.95909709
90MP0003828_pulmonary_edema0.95375855
91MP0010307_abnormal_tumor_latency0.94855785
92MP0000751_myopathy0.94799490
93MP0003632_abnormal_nervous_system0.94189345
94MP0002085_abnormal_embryonic_tissue0.93398295
95MP0000747_muscle_weakness0.92990519
96MP0003123_paternal_imprinting0.91173005
97MP0002063_abnormal_learning/memory/cond0.90951306
98MP0009703_decreased_birth_body0.90700123
99MP0004947_skin_inflammation0.90126806
100MP0010678_abnormal_skin_adnexa0.89826597
101MP0002896_abnormal_bone_mineralization0.89720539
102MP0004019_abnormal_vitamin_homeostasis0.89017440
103MP0000377_abnormal_hair_follicle0.88334151
104MP0009643_abnormal_urine_homeostasis0.87808691
105MP0002971_abnormal_brown_adipose0.87669440
106MP0001851_eye_inflammation0.87548796
107MP0003950_abnormal_plasma_membrane0.87409865
108MP0003566_abnormal_cell_adhesion0.86415805
109MP0002092_abnormal_eye_morphology0.85719142
110MP0003385_abnormal_body_wall0.85335086
111MP0003693_abnormal_embryo_hatching0.84383348
112MP0002078_abnormal_glucose_homeostasis0.84037465
113MP0004811_abnormal_neuron_physiology0.81441081
114MP0000762_abnormal_tongue_morphology0.80995998
115MP0003634_abnormal_glial_cell0.80773149
116MP0005451_abnormal_body_composition0.80583094
117MP0002254_reproductive_system_inflammat0.80528710
118MP0003221_abnormal_cardiomyocyte_apopto0.79126685
119MP0004043_abnormal_pH_regulation0.78135503
120MP0002697_abnormal_eye_size0.77935163
121MP0004197_abnormal_fetal_growth/weight/0.77591209
122MP0003453_abnormal_keratinocyte_physiol0.77385209
123MP0005501_abnormal_skin_physiology0.77168505
124MP0005670_abnormal_white_adipose0.77126271
125MP0002138_abnormal_hepatobiliary_system0.76771644
126MP0005623_abnormal_meninges_morphology0.75658307
127MP0001340_abnormal_eyelid_morphology0.75537689
128MP0000858_altered_metastatic_potential0.75268223
129MP0001756_abnormal_urination0.75262114
130MP0000598_abnormal_liver_morphology0.74871911
131MP0003075_altered_response_to0.74864511
132MP0001348_abnormal_lacrimal_gland0.74593590
133MP0006138_congestive_heart_failure0.74500608
134MP0003303_peritoneal_inflammation0.74484180
135MP0001299_abnormal_eye_distance/0.73387879
136MP0005535_abnormal_body_temperature0.73011878
137MP0000955_abnormal_spinal_cord0.68600923
138MP0002084_abnormal_developmental_patter0.66179597
139MP0003119_abnormal_digestive_system0.66016776
140MP0002733_abnormal_thermal_nociception0.65906858
141MP0001881_abnormal_mammary_gland0.65266907
142MP0001177_atelectasis0.64229315
143MP0002269_muscular_atrophy0.62540075
144MP0005334_abnormal_fat_pad0.61987436
145MP0005448_abnormal_energy_balance0.61554930
146MP0002822_catalepsy0.61407841
147MP0005248_abnormal_Harderian_gland0.61145149
148MP0002064_seizures0.60798317
149MP0008770_decreased_survivor_rate0.60446273
150MP0003631_nervous_system_phenotype0.60433316
151MP0005023_abnormal_wound_healing0.60326061
152MP0001440_abnormal_grooming_behavior0.59705606
153MP0003091_abnormal_cell_migration0.58887951
154MP0005275_abnormal_skin_tensile0.58009697
155MP0002653_abnormal_ependyma_morphology0.58000635
156MP0003890_abnormal_embryonic-extraembry0.57812698

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.72751867
2Xanthomatosis (HP:0000991)3.74801120
3Intrahepatic cholestasis (HP:0001406)3.57686088
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.45539716
5Insidious onset (HP:0003587)3.43430574
6Termporal pattern (HP:0011008)3.43430574
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35329378
8Hypobetalipoproteinemia (HP:0003563)3.32240619
9Cerebral inclusion bodies (HP:0100314)3.29250268
10Abnormality of the lower motor neuron (HP:0002366)3.25057045
11Complement deficiency (HP:0004431)3.08127499
12Abnormality of the Achilles tendon (HP:0005109)3.05403033
13Spastic diplegia (HP:0001264)3.02686666
14Distal lower limb amyotrophy (HP:0008944)3.02615521
15Epidermoid cyst (HP:0200040)2.82772226
16Achilles tendon contracture (HP:0001771)2.77091742
17Gout (HP:0001997)2.76605642
18Hyperglycinemia (HP:0002154)2.74996814
19Lower limb amyotrophy (HP:0007210)2.73666128
20Hyperlipoproteinemia (HP:0010980)2.73336778
21Hyperammonemia (HP:0001987)2.65047694
22Ketosis (HP:0001946)2.64426116
23Abnormality of glycine metabolism (HP:0010895)2.60565545
24Abnormality of serine family amino acid metabolism (HP:0010894)2.60565545
25Back pain (HP:0003418)2.53556571
26Heterotopia (HP:0002282)2.52128094
27Abnormality of oral frenula (HP:0000190)2.51970867
28Neurofibrillary tangles (HP:0002185)2.49740899
29Hypolipoproteinemia (HP:0010981)2.47960208
30Long palpebral fissure (HP:0000637)2.45253990
31Hyperglycinuria (HP:0003108)2.44216207
32Premature rupture of membranes (HP:0001788)2.43149500
33Vertebral arch anomaly (HP:0008438)2.41629561
34Supranuclear gaze palsy (HP:0000605)2.41494484
35Global brain atrophy (HP:0002283)2.41060377
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.38800780
37Protrusio acetabuli (HP:0003179)2.34602986
38Distal upper limb amyotrophy (HP:0007149)2.34200845
39Upper limb amyotrophy (HP:0009129)2.34200845
40Asymmetry of the thorax (HP:0001555)2.32883418
41Resting tremor (HP:0002322)2.32456433
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30866003
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.30667475
44Papillary thyroid carcinoma (HP:0002895)2.30288765
45Hand muscle atrophy (HP:0009130)2.29403972
46Relative macrocephaly (HP:0004482)2.26998675
47Spinal cord lesions (HP:0100561)2.25815003
48Syringomyelia (HP:0003396)2.25815003
49Abnormality of the common coagulation pathway (HP:0010990)2.23090881
50Abnormality of complement system (HP:0005339)2.22431449
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21230565
52Urinary urgency (HP:0000012)2.21177639
53Ketoacidosis (HP:0001993)2.17168753
54Turricephaly (HP:0000262)2.13230073
55Hypoalphalipoproteinemia (HP:0003233)2.12531167
56Flat acetabular roof (HP:0003180)2.12247275
57Abnormality of the corticospinal tract (HP:0002492)2.11831701
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.11490609
59Osteolytic defects of the hand bones (HP:0009699)2.11490609
60Amyotrophic lateral sclerosis (HP:0007354)2.11064087
61Action tremor (HP:0002345)2.09284149
62Cortical dysplasia (HP:0002539)2.09131153
63Neonatal onset (HP:0003623)2.09097597
64Malnutrition (HP:0004395)2.08362379
65Deep palmar crease (HP:0006191)2.07756900
66Intention tremor (HP:0002080)2.07317334
67Dysmetric saccades (HP:0000641)2.05586729
68Broad face (HP:0000283)2.04499500
69Morphological abnormality of the pyramidal tract (HP:0002062)2.04421736
70Impaired vibration sensation in the lower limbs (HP:0002166)2.03963458
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02872776
72Increased connective tissue (HP:0009025)2.02577785
73Cholecystitis (HP:0001082)2.01783635
74Abnormal gallbladder physiology (HP:0012438)2.01783635
75Deep philtrum (HP:0002002)2.01518918
76Vertebral compression fractures (HP:0002953)1.99697903
77Visual hallucinations (HP:0002367)1.98736681
78Myokymia (HP:0002411)1.97961778
79Pseudobulbar signs (HP:0002200)1.97902711
80Insomnia (HP:0100785)1.95808108
81Hypoglycemic coma (HP:0001325)1.95770145
82Deviation of the thumb (HP:0009603)1.95690960
83Impaired social interactions (HP:0000735)1.94303736
84Abnormal social behavior (HP:0012433)1.94303736
85Spastic tetraparesis (HP:0001285)1.92564541
86Tetraplegia (HP:0002445)1.90128726
87Enlarged penis (HP:0000040)1.89059473
88Fat malabsorption (HP:0002630)1.88829928
89Hammertoe (HP:0001765)1.88808763
90Macroorchidism (HP:0000053)1.87366666
91Spinal rigidity (HP:0003306)1.87349986
92Decreased motor nerve conduction velocity (HP:0003431)1.86982170
93Urinary bladder sphincter dysfunction (HP:0002839)1.86889714
94Spastic gait (HP:0002064)1.86112870
95Leiomyosarcoma (HP:0100243)1.86069744
96Uterine leiomyosarcoma (HP:0002891)1.86069744
97Hepatocellular carcinoma (HP:0001402)1.85107103
98Sensorimotor neuropathy (HP:0007141)1.85092264
99Pointed chin (HP:0000307)1.84185311
100Abnormality of purine metabolism (HP:0004352)1.83931384
101Neonatal hypoglycemia (HP:0001998)1.82408173
102Skin nodule (HP:0200036)1.81844050
103Cubitus valgus (HP:0002967)1.81462295
104Status epilepticus (HP:0002133)1.80453345
105Wormian bones (HP:0002645)1.79607500
106Pelvic girdle muscle weakness (HP:0003749)1.79297090
107Hyperacusis (HP:0010780)1.79223080
108Disproportionate tall stature (HP:0001519)1.78522173
109Scanning speech (HP:0002168)1.77642372
110Arnold-Chiari malformation (HP:0002308)1.76156842
111Ankyloglossia (HP:0010296)1.76104875
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.74701751
113Increased nuchal translucency (HP:0010880)1.74514188
114Distal sensory impairment (HP:0002936)1.74449551
115Abnormality of skeletal muscle fiber size (HP:0012084)1.74408976
116Abnormal cartilage morphology (HP:0002763)1.73681986
117Sparse lateral eyebrow (HP:0005338)1.73571659
118Progressive external ophthalmoplegia (HP:0000590)1.73209046
119Short nail (HP:0001799)1.72751275
120Postural instability (HP:0002172)1.72667531
121Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72207981
122Proximal placement of thumb (HP:0009623)1.72202879
123Glomerulosclerosis (HP:0000096)1.71586767
124Mitral regurgitation (HP:0001653)1.70988181
125Transitional cell carcinoma of the bladder (HP:0006740)1.70743295
126Tetraparesis (HP:0002273)1.70545034
127Clonus (HP:0002169)1.70095242
128Arterial tortuosity (HP:0005116)1.69769781
129Astrocytoma (HP:0009592)1.69638229
130Abnormality of the astrocytes (HP:0100707)1.69638229
131Overriding aorta (HP:0002623)1.68952701
132Torticollis (HP:0000473)1.68623090
133Cholelithiasis (HP:0001081)1.68428380
134Precocious puberty (HP:0000826)1.68091360
135Selective tooth agenesis (HP:0001592)1.68047769
136Increased variability in muscle fiber diameter (HP:0003557)1.67821776
137Atrophic scars (HP:0001075)1.67255654
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66870847
139Ulnar bowing (HP:0003031)1.66658221
140Advanced eruption of teeth (HP:0006288)1.66643683
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65606316
142Irritability (HP:0000737)1.65241349
143Elfin facies (HP:0004428)1.64739247
144Papilledema (HP:0001085)1.64580043
145Hypercholesterolemia (HP:0003124)1.64121190
146Overgrowth (HP:0001548)1.63923588
147Renal cell carcinoma (HP:0005584)1.63418848
148Neuronal loss in central nervous system (HP:0002529)1.63343049
149Ankle contracture (HP:0006466)1.63052127
150Abnormality of the intrinsic pathway (HP:0010989)1.62241980
151Delayed CNS myelination (HP:0002188)1.61637091
152Bronchomalacia (HP:0002780)1.61466395
153Cerebral aneurysm (HP:0004944)1.61318724
154Fibroma (HP:0010614)1.61220349
155Bladder carcinoma (HP:0002862)1.61089495
156Bladder neoplasm (HP:0009725)1.61089495
157Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60952247
158Obstructive sleep apnea (HP:0002870)1.60219413
159Prolonged partial thromboplastin time (HP:0003645)1.60196510
160Shallow orbits (HP:0000586)1.60165556
161Abnormal gallbladder morphology (HP:0012437)1.60018566
162Mildly elevated creatine phosphokinase (HP:0008180)1.59659219
163Intellectual disability, profound (HP:0002187)1.59217213
164Apathy (HP:0000741)1.58994581
165Ependymoma (HP:0002888)1.58189227
166Mitral valve prolapse (HP:0001634)1.58115864
167Abnormality of nucleobase metabolism (HP:0010932)1.57342149
168Hyperparathyroidism (HP:0000843)1.57260236
169Distal lower limb muscle weakness (HP:0009053)1.57176394
170Patellar dislocation (HP:0002999)1.57088042
171Lymphangioma (HP:0100764)1.56084354
172Depression (HP:0000716)1.55758577
173Subacute progressive viral hepatitis (HP:0006572)1.55568171
174Renal duplication (HP:0000075)1.55506540
175Germ cell neoplasia (HP:0100728)1.55495913
176Missing ribs (HP:0000921)1.55413789
177Shoulder girdle muscle weakness (HP:0003547)1.55015539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.69795208
2PRPF4B3.37944276
3MAP3K93.25255652
4PKN23.14080840
5KSR22.99194241
6LATS22.66440762
7EEF2K2.22683270
8SCYL22.20461518
9SMG12.08571892
10LATS12.07775752
11MAP3K22.05109675
12PAK62.03847922
13RIPK11.89294520
14ERN11.78454757
15BRD41.72743259
16KSR11.70870043
17SIK11.69225130
18MAP3K41.67113226
19RET1.61866274
20NEK11.61388411
21PRKD31.61027253
22MARK11.60247531
23MAP2K41.59639857
24MAP3K101.57624085
25NTRK11.56590911
26MAP3K131.50318188
27MAP3K61.49102485
28ALK1.46316392
29MINK11.43212813
30PTK61.38090559
31TAOK11.37838188
32BCKDK1.37068287
33ICK1.34952801
34TYRO31.31458110
35IRAK31.27912080
36NTRK31.25364243
37CAMKK11.25177829
38DAPK21.23820028
39ARAF1.23596235
40PDGFRA1.21708272
41MOS1.18485683
42BRAF1.17330313
43FGFR21.13280814
44PNCK1.13187697
45MAP3K141.12349909
46ERBB41.11700654
47PAK31.09196415
48FGFR41.09152386
49PDK41.06233926
50PDK31.06233926
51NEK91.02692025
52CAMK1G1.00670731
53STK381.00264571
54PTK20.97226891
55FER0.95319102
56BMX0.94614294
57LRRK20.89591859
58MET0.89246547
59MTOR0.89104311
60CAMK1D0.88214430
61CSNK1G20.87347199
62SIK30.85185000
63EPHA20.81460824
64MAP2K10.81248592
65MARK20.79602415
66AKT30.77947183
67TAOK20.77070493
68EPHA40.76127971
69PDPK10.72833011
70NEK60.72677292
71FGFR10.72019742
72MAP3K80.71216414
73TTK0.71135352
74EPHB10.69431357
75EIF2AK10.68602355
76PDK10.66712212
77WNK10.66503445
78CDK60.65990571
79PAK20.65735898
80CDK140.64429551
81LMTK20.64296891
82PRKCH0.64194992
83FGFR30.62770817
84STK110.62516832
85CDK50.62274533
86CDK40.62145895
87DYRK1B0.61973313
88TESK10.60696665
89RAF10.60307379
90CDK150.58955601
91FRK0.58258779
92MAPK100.58133508
93MAP3K10.57675473
94DMPK0.57405310
95PDGFRB0.55778846
96UHMK10.55522813
97CSNK1A1L0.55258804
98PBK0.54864115
99CSNK1G30.54111544
100YES10.52857241
101CDK180.52830036
102JAK20.52254288
103SGK4940.51840186
104SGK2230.51840186
105CSNK1E0.51755834
106PRKCZ0.51421791
107RPS6KA20.49643868
108CHEK10.49478744
109AKT20.49447837
110MAP2K30.49309279
111MST1R0.49079778
112NTRK20.48948774
113CSNK1G10.48826039
114BCR0.48122853
115CDK70.47896386
116SGK20.47839014
117SRPK10.47737996
118CDK11A0.47732667
119ERBB20.47286422
120LIMK10.46337612
121CDK120.45367886
122PRKAA10.43497772
123PDK20.43138914
124CSNK1D0.42887040
125SGK30.42526866
126GRK60.42196651
127BRSK10.41892003
128STK30.41461785
129TTN0.40945332
130SIK20.40293669
131TRPM70.38761949
132TESK20.38434224
133NEK20.37696463
134RPS6KA40.37244997
135MAP3K70.36422577
136PAK40.35613335
137MAPK110.35508504
138RPS6KB10.35175597
139ABL20.34864944
140RPS6KB20.34828025
141TSSK60.34772063
142STK100.34633893
143WNK40.34577574
144JAK10.33900878

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.72894944
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33606260
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.87090988
4Arginine biosynthesis_Homo sapiens_hsa002202.79495509
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41837032
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34809855
7Chronic myeloid leukemia_Homo sapiens_hsa052202.21537728
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15744400
9Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.10228013
10Butanoate metabolism_Homo sapiens_hsa006502.07672837
11Thyroid cancer_Homo sapiens_hsa052162.04162914
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02386904
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01604713
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84070970
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83305814
16Fatty acid degradation_Homo sapiens_hsa000711.80675551
17Pancreatic cancer_Homo sapiens_hsa052121.80589856
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80148524
19Propanoate metabolism_Homo sapiens_hsa006401.68081638
20Bile secretion_Homo sapiens_hsa049761.62754149
21PPAR signaling pathway_Homo sapiens_hsa033201.60024077
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.59444656
23Fatty acid metabolism_Homo sapiens_hsa012121.59368464
24Tryptophan metabolism_Homo sapiens_hsa003801.56876499
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.50571638
26Acute myeloid leukemia_Homo sapiens_hsa052211.45973425
27Colorectal cancer_Homo sapiens_hsa052101.42837717
28Biosynthesis of amino acids_Homo sapiens_hsa012301.42646516
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.40871430
30MicroRNAs in cancer_Homo sapiens_hsa052061.35530678
31Pyruvate metabolism_Homo sapiens_hsa006201.33142231
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32918787
33Small cell lung cancer_Homo sapiens_hsa052221.29606244
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28223071
35Complement and coagulation cascades_Homo sapiens_hsa046101.25583793
36Prostate cancer_Homo sapiens_hsa052151.25180401
37Carbon metabolism_Homo sapiens_hsa012001.24743519
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24317179
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20664345
40mRNA surveillance pathway_Homo sapiens_hsa030151.19425753
41Fatty acid biosynthesis_Homo sapiens_hsa000611.17786414
42Focal adhesion_Homo sapiens_hsa045101.16790058
43Fat digestion and absorption_Homo sapiens_hsa049751.15164455
44Prolactin signaling pathway_Homo sapiens_hsa049171.14765462
45Selenocompound metabolism_Homo sapiens_hsa004501.14394158
46Cell cycle_Homo sapiens_hsa041101.13404442
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12892861
48Inositol phosphate metabolism_Homo sapiens_hsa005621.12753475
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.11345428
50beta-Alanine metabolism_Homo sapiens_hsa004101.10141914
51Hepatitis B_Homo sapiens_hsa051611.01907451
52B cell receptor signaling pathway_Homo sapiens_hsa046620.99806383
53Viral carcinogenesis_Homo sapiens_hsa052030.97488798
54Choline metabolism in cancer_Homo sapiens_hsa052310.97451801
55Shigellosis_Homo sapiens_hsa051310.95698445
56Glycerolipid metabolism_Homo sapiens_hsa005610.93451013
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93361053
58Notch signaling pathway_Homo sapiens_hsa043300.93295944
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.91248917
60Caffeine metabolism_Homo sapiens_hsa002320.91206038
61Vibrio cholerae infection_Homo sapiens_hsa051100.90887536
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89751225
63Phenylalanine metabolism_Homo sapiens_hsa003600.88953782
64Vitamin B6 metabolism_Homo sapiens_hsa007500.87882838
65FoxO signaling pathway_Homo sapiens_hsa040680.87767009
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87263718
67Synaptic vesicle cycle_Homo sapiens_hsa047210.87167188
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87093099
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86528523
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85511649
71Peroxisome_Homo sapiens_hsa041460.85208139
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.85064399
73mTOR signaling pathway_Homo sapiens_hsa041500.82947579
74Apoptosis_Homo sapiens_hsa042100.82735883
75Amoebiasis_Homo sapiens_hsa051460.82001933
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.81415951
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80678155
78AMPK signaling pathway_Homo sapiens_hsa041520.80412141
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79526343
80Prion diseases_Homo sapiens_hsa050200.76831993
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76774695
82HIF-1 signaling pathway_Homo sapiens_hsa040660.76740286
83Long-term potentiation_Homo sapiens_hsa047200.76657388
84Endocytosis_Homo sapiens_hsa041440.75725378
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.75715328
86Insulin resistance_Homo sapiens_hsa049310.74558809
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74349416
88Sulfur metabolism_Homo sapiens_hsa009200.74158962
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74057970
90Dorso-ventral axis formation_Homo sapiens_hsa043200.73756848
91Glucagon signaling pathway_Homo sapiens_hsa049220.71982281
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.71107640
93Histidine metabolism_Homo sapiens_hsa003400.70315935
94Estrogen signaling pathway_Homo sapiens_hsa049150.70032670
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69820423
96Hepatitis C_Homo sapiens_hsa051600.69614224
97Glioma_Homo sapiens_hsa052140.66602636
98Lysine degradation_Homo sapiens_hsa003100.66120490
99Type II diabetes mellitus_Homo sapiens_hsa049300.65878853
100Pathways in cancer_Homo sapiens_hsa052000.65450535
101Salmonella infection_Homo sapiens_hsa051320.65088897
102Chemical carcinogenesis_Homo sapiens_hsa052040.64957257
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.64637386
104Melanogenesis_Homo sapiens_hsa049160.64368373
105Insulin signaling pathway_Homo sapiens_hsa049100.63421556
106Melanoma_Homo sapiens_hsa052180.62693869
107Dilated cardiomyopathy_Homo sapiens_hsa054140.61625178
108Axon guidance_Homo sapiens_hsa043600.59989548
109Rap1 signaling pathway_Homo sapiens_hsa040150.59620835
110ECM-receptor interaction_Homo sapiens_hsa045120.59100529
111Renal cell carcinoma_Homo sapiens_hsa052110.58217236
112T cell receptor signaling pathway_Homo sapiens_hsa046600.58194677
113Starch and sucrose metabolism_Homo sapiens_hsa005000.57869021
114Endometrial cancer_Homo sapiens_hsa052130.57767812
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57140520
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55262386
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54452096
118Steroid biosynthesis_Homo sapiens_hsa001000.54011276
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53786053
120VEGF signaling pathway_Homo sapiens_hsa043700.53641339
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52900662
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52443616
123Dopaminergic synapse_Homo sapiens_hsa047280.52277284
124MAPK signaling pathway_Homo sapiens_hsa040100.51952955
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51440053
126Tyrosine metabolism_Homo sapiens_hsa003500.50817714
127Bladder cancer_Homo sapiens_hsa052190.50547087
128Thyroid hormone synthesis_Homo sapiens_hsa049180.50156798
129Oocyte meiosis_Homo sapiens_hsa041140.48645527
130Tight junction_Homo sapiens_hsa045300.48131667
131* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47879035
132Non-small cell lung cancer_Homo sapiens_hsa052230.47569815
133Gastric acid secretion_Homo sapiens_hsa049710.47434409
134Pentose phosphate pathway_Homo sapiens_hsa000300.46812104
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46721547
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45621775
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.44348262
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43898118
139GABAergic synapse_Homo sapiens_hsa047270.43377481
140ErbB signaling pathway_Homo sapiens_hsa040120.43173881
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42848426
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42460878
143Hippo signaling pathway_Homo sapiens_hsa043900.42302381
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42109529
145Gap junction_Homo sapiens_hsa045400.40422592
146GnRH signaling pathway_Homo sapiens_hsa049120.39808797
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39519140
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39293884
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38961046
150Arginine and proline metabolism_Homo sapiens_hsa003300.37899324
151Adherens junction_Homo sapiens_hsa045200.37250354
152Amphetamine addiction_Homo sapiens_hsa050310.36967242
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.36765980
154Staphylococcus aureus infection_Homo sapiens_hsa051500.36361165
155Proteoglycans in cancer_Homo sapiens_hsa052050.35772620

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