UBQLN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.82843074
2epithelial cilium movement (GO:0003351)9.73955552
3motile cilium assembly (GO:0044458)9.64094158
4regulation of cilium movement (GO:0003352)9.26072073
5reproduction (GO:0000003)9.20209769
6cilium or flagellum-dependent cell motility (GO:0001539)9.20147221
7response to pheromone (GO:0019236)8.68819404
8cilium movement (GO:0003341)7.89263582
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.46270437
10single fertilization (GO:0007338)7.43094346
11piRNA metabolic process (GO:0034587)7.37010779
12phosphatidylethanolamine biosynthetic process (GO:0006646)7.34310978
13sperm capacitation (GO:0048240)7.17097501
14negative regulation of inclusion body assembly (GO:0090084)7.14680670
15synaptonemal complex organization (GO:0070193)7.05840661
16rRNA methylation (GO:0031167)7.01466286
17male meiosis (GO:0007140)6.91293744
18synaptonemal complex assembly (GO:0007130)6.83148903
19spermatogenesis (GO:0007283)6.81206710
20male gamete generation (GO:0048232)6.78714792
21phosphatidylethanolamine metabolic process (GO:0046337)6.78001912
22organic cation transport (GO:0015695)6.72467645
23microtubule depolymerization (GO:0007019)6.60981441
24fertilization (GO:0009566)6.34177040
25protein targeting to Golgi (GO:0000042)6.29442183
26gamete generation (GO:0007276)6.23523429
27establishment of protein localization to Golgi (GO:0072600)6.05625116
28cellular ketone body metabolic process (GO:0046950)5.97363421
29regulation of inclusion body assembly (GO:0090083)5.96365928
30rRNA modification (GO:0000154)5.91746672
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.88838564
32calcium ion-dependent exocytosis (GO:0017156)5.61869517
33regulation of microtubule-based movement (GO:0060632)5.48281508
34germ cell development (GO:0007281)5.48257919
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.44184999
36ketone body metabolic process (GO:1902224)5.27316960
37ventricular system development (GO:0021591)5.21969859
38chromosome condensation (GO:0030261)5.10512641
39cell recognition (GO:0008037)5.03249309
40male meiosis I (GO:0007141)4.95219890
41multicellular organismal reproductive process (GO:0048609)4.91882801
42glycerol ether metabolic process (GO:0006662)4.88758636
43DNA packaging (GO:0006323)4.88320013
44microtubule severing (GO:0051013)4.83941144
45seminiferous tubule development (GO:0072520)4.80186012
46centriole replication (GO:0007099)4.79560843
47positive regulation of Rab GTPase activity (GO:0032851)4.71418987
48regulation of Rab GTPase activity (GO:0032313)4.71418987
49DNA methylation involved in gamete generation (GO:0043046)4.68601416
50chromosome organization involved in meiosis (GO:0070192)4.65333566
51left/right pattern formation (GO:0060972)4.63394663
52ether metabolic process (GO:0018904)4.51592490
53chromatin silencing (GO:0006342)4.49871291
54protein localization to Golgi apparatus (GO:0034067)4.49434937
55regulation of transcription involved in cell fate commitment (GO:0060850)4.44395200
56centriole assembly (GO:0098534)4.38681761
57spermatid nucleus differentiation (GO:0007289)4.38065467
58meiotic nuclear division (GO:0007126)4.19414794
59regulation of somitogenesis (GO:0014807)4.12974287
60chaperone-mediated protein complex assembly (GO:0051131)4.03809085
61meiosis I (GO:0007127)3.95830449
62multicellular organismal development (GO:0007275)3.95540214
63negative regulation of Rho protein signal transduction (GO:0035024)3.91128198
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87446837
65response to acidic pH (GO:0010447)3.81858625
66protein polyglutamylation (GO:0018095)3.76119507
67nucleosome disassembly (GO:0006337)3.73261721
68multicellular organismal movement (GO:0050879)3.69410423
69musculoskeletal movement (GO:0050881)3.69410423
70coenzyme catabolic process (GO:0009109)3.66222044
71regulation of centriole replication (GO:0046599)3.62806388
72genitalia morphogenesis (GO:0035112)3.61104347
73sexual reproduction (GO:0019953)3.59267934
74cellular response to pH (GO:0071467)3.55105799
75single strand break repair (GO:0000012)3.54307795
76regulation of spindle checkpoint (GO:0090231)3.53012755
77meiotic cell cycle (GO:0051321)3.44189942
78sequestering of actin monomers (GO:0042989)3.40540126
79peptidyl-threonine dephosphorylation (GO:0035970)3.40465976
80protein localization to cilium (GO:0061512)3.36176347
81microtubule polymerization or depolymerization (GO:0031109)3.35749983
82membrane protein intracellular domain proteolysis (GO:0031293)3.34951340
83protein refolding (GO:0042026)3.34341737
84carnitine transport (GO:0015879)3.32643377
85amino-acid betaine transport (GO:0015838)3.32643377
86homeostasis of number of cells within a tissue (GO:0048873)3.29401122
87regulation of interleukin-13 production (GO:0032656)3.26374394
88RNA localization (GO:0006403)3.23097812
89monoubiquitinated protein deubiquitination (GO:0035520)3.22896131
90regulation of T-helper 2 cell differentiation (GO:0045628)3.22648065
91regulation of phosphoprotein phosphatase activity (GO:0043666)3.21753497
92interferon-gamma secretion (GO:0072643)3.20246811
93mitotic sister chromatid cohesion (GO:0007064)3.19503966
94cranial nerve morphogenesis (GO:0021602)3.17597111
95carnitine transmembrane transport (GO:1902603)3.16558968
96cerebral cortex neuron differentiation (GO:0021895)3.15406647
97RNA destabilization (GO:0050779)3.14538185
98glycolytic process (GO:0006096)3.12074286
99polyol catabolic process (GO:0046174)3.10885910
100nucleus organization (GO:0006997)3.07722300
101protein K11-linked deubiquitination (GO:0035871)3.05971003
102negative regulation of gene expression, epigenetic (GO:0045814)3.03254448
103histone H3-K9 demethylation (GO:0033169)3.00054546
104cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.99147096
105mitochondrial fission (GO:0000266)2.98562356
106nucleoside diphosphate phosphorylation (GO:0006165)2.95441311
107microtubule nucleation (GO:0007020)2.94873034
108alditol metabolic process (GO:0019400)2.92445872
109negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.91618875
110DNA conformation change (GO:0071103)2.90989460
111protein depolymerization (GO:0051261)2.89047889
112cellular biogenic amine biosynthetic process (GO:0042401)2.88249387
113mitotic G1 DNA damage checkpoint (GO:0031571)2.81786366
114cilium organization (GO:0044782)2.81236961
115tooth mineralization (GO:0034505)2.79540856
116synapsis (GO:0007129)2.77874993
117neurofilament cytoskeleton organization (GO:0060052)2.77223790
118meiotic cell cycle process (GO:1903046)2.76871036
119microtubule-based movement (GO:0007018)2.75595197
120positive regulation of macrophage activation (GO:0043032)2.74847216
121peptidyl-glutamic acid modification (GO:0018200)2.74019537
122regulation of cilium assembly (GO:1902017)2.73626557
123gene silencing by RNA (GO:0031047)2.73596001
124cilium morphogenesis (GO:0060271)2.73434379
125amine biosynthetic process (GO:0009309)2.71466766
126cilium assembly (GO:0042384)2.69968838
127negative regulation of organelle assembly (GO:1902116)2.69885708
128positive regulation of skeletal muscle tissue development (GO:0048643)2.69342656
129polyamine biosynthetic process (GO:0006596)2.68345139
130axoneme assembly (GO:0035082)2.66629741
131cellular component assembly involved in morphogenesis (GO:0010927)2.64750763
132intraciliary transport (GO:0042073)2.63663940
133GTP biosynthetic process (GO:0006183)2.63541586
134lactate metabolic process (GO:0006089)2.60218968
135mitochondrion degradation (GO:0000422)2.52240293
136negative regulation of skeletal muscle tissue development (GO:0048642)2.50981521
137protein-DNA complex disassembly (GO:0032986)2.46376384
138sperm motility (GO:0030317)14.1659536
139fusion of sperm to egg plasma membrane (GO:0007342)13.2176305
140acrosome reaction (GO:0007340)12.4682676
141cell wall macromolecule catabolic process (GO:0016998)11.9127504
142cell wall macromolecule metabolic process (GO:0044036)11.9127504
143sperm-egg recognition (GO:0035036)11.6086556
144acrosome assembly (GO:0001675)11.1632617
145multicellular organism reproduction (GO:0032504)10.8047886
146binding of sperm to zona pellucida (GO:0007339)10.6071590
147cell-cell recognition (GO:0009988)10.3849699
148axonemal dynein complex assembly (GO:0070286)10.0809804
149plasma membrane fusion (GO:0045026)10.0658466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.60669409
2EZH2_22144423_ChIP-Seq_EOC_Human4.50124626
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.49219875
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.03630372
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.48585572
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28226464
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.96979162
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91061538
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88149364
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.81467105
11VDR_22108803_ChIP-Seq_LS180_Human2.47748095
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.30247739
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.29295034
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.20510807
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10229987
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02489408
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00160001
18ZNF274_21170338_ChIP-Seq_K562_Hela1.98201567
19DROSHA_22980978_ChIP-Seq_HELA_Human1.92601247
20RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.90895200
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.90735606
22ERA_21632823_ChIP-Seq_H3396_Human1.89989101
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89419260
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87153140
25RAC3_21632823_ChIP-Seq_H3396_Human1.86820058
26CTCF_27219007_Chip-Seq_Bcells_Human1.86238198
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79992802
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.78669767
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78614279
30BCL6_27268052_Chip-Seq_Bcells_Human1.76861554
31STAT1_17558387_ChIP-Seq_HELA_Human1.72433906
32SMC4_20622854_ChIP-Seq_HELA_Human1.70398496
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69955969
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.65823382
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.65592887
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65170786
37E2F1_20622854_ChIP-Seq_HELA_Human1.63501933
38TAF2_19829295_ChIP-Seq_ESCs_Human1.60805949
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.59871937
40PHF8_20622854_ChIP-Seq_HELA_Human1.59366940
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58874763
42FUS_26573619_Chip-Seq_HEK293_Human1.58222817
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.56664159
44P68_20966046_ChIP-Seq_HELA_Human1.56362635
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53568329
46OCT4_20526341_ChIP-Seq_ESCs_Human1.53234732
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.51467143
48LXR_22292898_ChIP-Seq_THP-1_Human1.51317199
49TP63_22573176_ChIP-Seq_HFKS_Human1.50895290
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50696366
51GATA3_21867929_ChIP-Seq_CD8_Mouse1.50689150
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50311274
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47035653
54FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.45937045
55MYC_19829295_ChIP-Seq_ESCs_Human1.45681308
56P300_27268052_Chip-Seq_Bcells_Human1.45169354
57CBP_20019798_ChIP-Seq_JUKART_Human1.42962307
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42962307
59ER_23166858_ChIP-Seq_MCF-7_Human1.42689191
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.42474931
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.41756888
62KDM2B_26808549_Chip-Seq_REH_Human1.39305000
63AR_25329375_ChIP-Seq_VCAP_Human1.38798781
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.38629798
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38356021
66P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.38103561
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37821632
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35683327
69RUNX_20019798_ChIP-Seq_JUKART_Human1.34621022
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33867478
71P53_21459846_ChIP-Seq_SAOS-2_Human1.33648106
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32704365
73LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32513816
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32224867
75RBPJ_21746931_ChIP-Seq_IB4_Human1.32103451
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31626690
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.31334245
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31195091
79REST_21632747_ChIP-Seq_MESCs_Mouse1.31160965
80* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31066326
81HNFA_21074721_ChIP-Seq_CACO-2_Human1.29322708
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28200697
83CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28031965
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27516508
85TP53_18474530_ChIP-ChIP_U2OS_Human1.26636078
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.26472381
87CEBPB_22108803_ChIP-Seq_LS180_Human1.24712231
88ETV1_20927104_ChIP-Seq_GIST48_Human1.23569100
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23423781
90GATA3_21867929_ChIP-Seq_TH1_Mouse1.22824358
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20089662
92GF1_26923725_Chip-Seq_HPCs_Mouse1.19753481
93SMRT_27268052_Chip-Seq_Bcells_Human1.18956016
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.18640021
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.18293514
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.17510591
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.17442765
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.17442485
99CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17286987
100SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17053082
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.13879887
102SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13856436
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13235816
104RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12201061
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10910233
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10910233
107SPI1_26923725_Chip-Seq_HPCs_Mouse1.10515859
108MYC_27129775_Chip-Seq_CORNEA_Mouse1.09833990
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09731814
110P300_19829295_ChIP-Seq_ESCs_Human1.09332132
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09057324
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08900416
113ERG_20517297_ChIP-Seq_VCAP_Human1.08616398
114RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08600352
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07117999
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06758926
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06689178
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06054141
119OCT1_27270436_Chip-Seq_PROSTATE_Human1.05259440
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04814324
121EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04737633
122NANOG_19829295_ChIP-Seq_ESCs_Human1.04676980
123SOX2_19829295_ChIP-Seq_ESCs_Human1.04676980
124SMAD4_21741376_ChIP-Seq_HESCs_Human1.04377962
125* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03920810
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.03738623
127* SA1_27219007_Chip-Seq_Bcells_Human1.03733440
128TET1_21451524_ChIP-Seq_MESCs_Mouse1.03188752
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03162885
130CSB_26484114_Chip-Seq_FIBROBLAST_Human1.02822866
131CTCF_20526341_ChIP-Seq_ESCs_Human1.02374421
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.01277857
133SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01231007
134OCT4_19829295_ChIP-Seq_ESCs_Human1.01189449
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01164831
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00930438
137YY1_22570637_ChIP-Seq_MALME-3M_Human1.00336323
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00193393
139TP63_19390658_ChIP-ChIP_HaCaT_Human1.00184482
140SA1_27219007_Chip-Seq_ERYTHROID_Human1.00142940
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.99724590
142PHF8_20622853_ChIP-Seq_HELA_Human0.99668936
143GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99387203
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.99085671
145RUNX2_22187159_ChIP-Seq_PCA_Human0.98999920
146JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98851552
147TAF15_26573619_Chip-Seq_HEK293_Human0.98571497
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98362511
149KLF4_19829295_ChIP-Seq_ESCs_Human0.97777663
150FOXH1_21741376_ChIP-Seq_ESCs_Human0.97682989
151SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97429021
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.96751342
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94378274
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93424135
155LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92953668
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.92791138
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92021388
158* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89245778
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.89062120
160NFYB_21822215_ChIP-Seq_K562_Human0.88758099
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88696415
162NANOG_20526341_ChIP-Seq_ESCs_Human0.86459495
163BCOR_27268052_Chip-Seq_Bcells_Human0.86397454
164OCT4_18555785_Chip-Seq_ESCs_Mouse0.85923924
165KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85314508
166RNF2_27304074_Chip-Seq_NSC_Mouse0.85179080
167STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84196761
168OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84182248
169TBL1_22424771_ChIP-Seq_293T_Human0.84141515
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83677819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02655928
2MP0001929_abnormal_gametogenesis5.43480582
3MP0008877_abnormal_DNA_methylation3.96933029
4MP0002210_abnormal_sex_determination3.29269481
5MP0002161_abnormal_fertility/fecundity3.29246369
6MP0005670_abnormal_white_adipose3.02203755
7MP0001145_abnormal_male_reproductive2.80376984
8MP0001348_abnormal_lacrimal_gland2.79491848
9MP0000678_abnormal_parathyroid_gland2.70184558
10MP0000653_abnormal_sex_gland2.41769241
11MP0002653_abnormal_ependyma_morphology2.32456631
12MP0003718_maternal_effect2.17705801
13MP0005410_abnormal_fertilization16.6560283
14MP0002132_abnormal_respiratory_system1.85072074
15MP0003646_muscle_fatigue1.69783929
16MP0002160_abnormal_reproductive_system1.59510206
17MP0002249_abnormal_larynx_morphology1.55862765
18MP0004233_abnormal_muscle_weight1.44150350
19MP0005310_abnormal_salivary_gland1.41108320
20MP0005623_abnormal_meninges_morphology1.40005039
21MP0002822_catalepsy1.36349900
22MP0001485_abnormal_pinna_reflex1.36210245
23MP0002282_abnormal_trachea_morphology1.30228694
24MP0002138_abnormal_hepatobiliary_system1.27620695
25MP0009053_abnormal_anal_canal1.26073378
26MP0001486_abnormal_startle_reflex1.22204828
27MP0005379_endocrine/exocrine_gland_phen1.18113435
28MP0005451_abnormal_body_composition1.17663055
29MP0001765_abnormal_ion_homeostasis1.12918293
30MP0002735_abnormal_chemical_nociception1.12766510
31MP0002127_abnormal_cardiovascular_syste1.10634552
32MP0004859_abnormal_synaptic_plasticity1.09835766
33MP0004510_myositis1.01002088
34MP0005395_other_phenotype1.00760077
35MP0001984_abnormal_olfaction0.98735031
36MP0000681_abnormal_thyroid_gland0.96058333
37MP0001963_abnormal_hearing_physiology0.95889717
38MP0005248_abnormal_Harderian_gland0.90338439
39MP0001879_abnormal_lymphatic_vessel0.88359546
40MP0002229_neurodegeneration0.88201227
41MP0003115_abnormal_respiratory_system0.87299511
42MP0000026_abnormal_inner_ear0.87114408
43MP0008995_early_reproductive_senescence0.86833629
44MP0000955_abnormal_spinal_cord0.84956311
45MP0005647_abnormal_sex_gland0.83620422
46MP0005389_reproductive_system_phenotype0.78574134
47MP0000049_abnormal_middle_ear0.77001758
48MP0009046_muscle_twitch0.73557893
49MP0000613_abnormal_salivary_gland0.72819552
50MP0003878_abnormal_ear_physiology0.72571561
51MP0005377_hearing/vestibular/ear_phenot0.72571561
52MP0002067_abnormal_sensory_capabilities0.72295016
53MP0003011_delayed_dark_adaptation0.70606158
54MP0002234_abnormal_pharynx_morphology0.70480403
55MP0001873_stomach_inflammation0.68592551
56MP0002557_abnormal_social/conspecific_i0.68376302
57MP0001666_abnormal_nutrient_absorption0.67678329
58MP0001905_abnormal_dopamine_level0.67460600
59MP0008058_abnormal_DNA_repair0.67384986
60MP0005083_abnormal_biliary_tract0.66308415
61MP0005666_abnormal_adipose_tissue0.65984214
62MP0005636_abnormal_mineral_homeostasis0.59301727
63MP0004484_altered_response_of0.59196856
64MP0003329_amyloid_beta_deposits0.58864173
65MP0004085_abnormal_heartbeat0.57754811
66MP0009278_abnormal_bone_marrow0.53224859
67MP0000569_abnormal_digit_pigmentation0.52748815
68MP0001324_abnormal_eye_pigmentation0.52339610
69MP0002733_abnormal_thermal_nociception0.52249696
70MP0003077_abnormal_cell_cycle0.51471343
71MP0004036_abnormal_muscle_relaxation0.50153387
72MP0000358_abnormal_cell_content/0.49855790
73MP0002272_abnormal_nervous_system0.49273383
74MP0005397_hematopoietic_system_phenotyp0.49247650
75MP0001545_abnormal_hematopoietic_system0.49247650
76MP0000249_abnormal_blood_vessel0.49170372
77MP0001270_distended_abdomen0.48463751
78MP0002254_reproductive_system_inflammat0.47444545
79MP0001764_abnormal_homeostasis0.47170836
80MP0000534_abnormal_ureter_morphology0.46845140
81MP0002269_muscular_atrophy0.45273754
82MP0005367_renal/urinary_system_phenotyp0.44931017
83MP0000516_abnormal_urinary_system0.44931017
84MP0003699_abnormal_female_reproductive0.44884580
85MP0001293_anophthalmia0.44410139
86MP0010094_abnormal_chromosome_stability0.44294793
87MP0002572_abnormal_emotion/affect_behav0.44135195
88MP0009745_abnormal_behavioral_response0.43860216
89MP0000003_abnormal_adipose_tissue0.43453393
90MP0010329_abnormal_lipoprotein_level0.41885166
91MP0002928_abnormal_bile_duct0.41276336
92MP0001440_abnormal_grooming_behavior0.40950068
93MP0003137_abnormal_impulse_conducting0.39929772
94MP0009115_abnormal_fat_cell0.39447849
95MP0000470_abnormal_stomach_morphology0.38118525
96MP0005253_abnormal_eye_physiology0.37745667
97MP0005167_abnormal_blood-brain_barrier0.37671146
98MP0005535_abnormal_body_temperature0.36771909
99MP0003950_abnormal_plasma_membrane0.35520920
100MP0005166_decreased_susceptibility_to0.35453538
101MP0005551_abnormal_eye_electrophysiolog0.35423785
102MP0002736_abnormal_nociception_after0.35390998
103MP0003942_abnormal_urinary_system0.35365883
104MP0001970_abnormal_pain_threshold0.35284704
105MP0006036_abnormal_mitochondrial_physio0.35158035
106MP0005423_abnormal_somatic_nervous0.34754329
107MP0008961_abnormal_basal_metabolism0.34729702
108MP0003119_abnormal_digestive_system0.34671891
109MP0002734_abnormal_mechanical_nocicepti0.34593716
110MP0003091_abnormal_cell_migration0.33941193
111MP0001501_abnormal_sleep_pattern0.33251386
112MP0002971_abnormal_brown_adipose0.32995282
113MP0006292_abnormal_olfactory_placode0.32598509
114MP0003111_abnormal_nucleus_morphology0.32211226
115MP0001986_abnormal_taste_sensitivity0.31663735
116MP0003936_abnormal_reproductive_system0.31362020
117MP0003879_abnormal_hair_cell0.31236537
118MP0009697_abnormal_copulation0.30945025
119MP0002295_abnormal_pulmonary_circulatio0.30252079
120MP0004811_abnormal_neuron_physiology0.30202004
121MP0000230_abnormal_systemic_arterial0.30112242
122MP0003635_abnormal_synaptic_transmissio0.29743820
123MP0000604_amyloidosis0.29684535
124MP0005391_vision/eye_phenotype0.29214219
125MP0003632_abnormal_nervous_system0.29201177
126MP0003633_abnormal_nervous_system0.27956237
127MP0001730_embryonic_growth_arrest0.26351605
128MP0004133_heterotaxia0.26265366
129MP0003948_abnormal_gas_homeostasis0.25686998
130MP0003861_abnormal_nervous_system0.25534873
131MP0001661_extended_life_span0.24687103
132MP0005375_adipose_tissue_phenotype0.24309144
133MP0003786_premature_aging0.24191197
134MP0002139_abnormal_hepatobiliary_system0.23525887
135MP0002152_abnormal_brain_morphology0.23191418
136MP0002169_no_abnormal_phenotype0.22212363
137MP0003631_nervous_system_phenotype0.22050799
138MP0002873_normal_phenotype0.21973467
139MP0001119_abnormal_female_reproductive0.21634122
140MP0001849_ear_inflammation0.21545384
141MP0006035_abnormal_mitochondrial_morpho0.21245847
142MP0004742_abnormal_vestibular_system0.19940005
143MP0004270_analgesia0.19801324
144MP0004019_abnormal_vitamin_homeostasis0.19237371
145MP0001727_abnormal_embryo_implantation0.19222172
146MP0000751_myopathy0.18814036
147MP0004808_abnormal_hematopoietic_stem0.18675276
148MP0001968_abnormal_touch/_nociception0.17803971
149MP0003959_abnormal_lean_body0.17693068
150MP0002102_abnormal_ear_morphology0.17267649
151MP0003045_fibrosis0.16961884
152MP0004043_abnormal_pH_regulation0.16794400
153MP0003787_abnormal_imprinting0.16197627
154MP0002092_abnormal_eye_morphology0.15661489
155MP0008007_abnormal_cellular_replicative0.14992798
156MP0000313_abnormal_cell_death0.14574701
157MP0008875_abnormal_xenobiotic_pharmacok0.13981092
158MP0000001_mammalian_phenotype0.13890169
159MP0002118_abnormal_lipid_homeostasis0.13498606
160MP0004130_abnormal_muscle_cell0.13213672
161MP0005365_abnormal_bile_salt0.13080221
162MP0010307_abnormal_tumor_latency0.13048827
163MP0002084_abnormal_developmental_patter0.13021060
164MP0008569_lethality_at_weaning0.12965012

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.21861518
2Abnormal respiratory motile cilium morphology (HP:0005938)9.21861518
3Abnormal respiratory motile cilium physiology (HP:0012261)9.13744209
4Severe visual impairment (HP:0001141)8.08734225
5Rhinitis (HP:0012384)7.37789720
6Chronic bronchitis (HP:0004469)7.22971694
7Infertility (HP:0000789)7.14557866
8Abnormal ciliary motility (HP:0012262)7.05549414
9Nasal polyposis (HP:0100582)6.43950726
10Abnormality of the nasal mucosa (HP:0000433)5.30172319
11Male infertility (HP:0003251)5.11511348
12Hyperkalemia (HP:0002153)5.06222912
13Bony spicule pigmentary retinopathy (HP:0007737)4.89814463
14Chronic hepatic failure (HP:0100626)4.81327883
15Attenuation of retinal blood vessels (HP:0007843)4.80488366
16Resting tremor (HP:0002322)4.69620251
17Bronchitis (HP:0012387)4.66039208
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.63180647
19Bronchiectasis (HP:0002110)4.39574469
20Nephronophthisis (HP:0000090)4.20522568
21Abnormality of macular pigmentation (HP:0008002)4.09454439
22Potter facies (HP:0002009)4.03893654
23Facial shape deformation (HP:0011334)4.03893654
24Abnormal rod and cone electroretinograms (HP:0008323)3.86964389
25Abnormal spermatogenesis (HP:0008669)3.82801025
26Cone-rod dystrophy (HP:0000548)3.77319419
27Hypoplastic ischia (HP:0003175)3.63442200
28Hypoplasia of the thymus (HP:0000778)3.53288998
29Postural instability (HP:0002172)3.36629545
30Recurrent otitis media (HP:0000403)3.33374812
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.30256148
32Abnormality of the ischium (HP:0003174)3.24153148
33Unilateral renal agenesis (HP:0000122)3.21474299
34Recurrent sinusitis (HP:0011108)3.20203290
35Abnormality of the renal medulla (HP:0100957)3.14907965
36Hypoalphalipoproteinemia (HP:0003233)3.11019066
37Progressive sensorineural hearing impairment (HP:0000408)3.09957580
38Impulsivity (HP:0100710)3.01911573
39Abnormality of the aortic arch (HP:0012303)2.99414466
40Recurrent bronchitis (HP:0002837)2.94750885
41Enlarged epiphyses (HP:0010580)2.92567986
42Amelogenesis imperfecta (HP:0000705)2.83264515
43Menstrual irregularities (HP:0000858)2.81714935
44Abnormality of potassium homeostasis (HP:0011042)2.81540653
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.78329831
46Generalized aminoaciduria (HP:0002909)2.76515012
47Tubulointerstitial nephritis (HP:0001970)2.76214178
48Renovascular hypertension (HP:0100817)2.74479317
49Abnormality of the parathyroid morphology (HP:0011766)2.67631956
50Gonadotropin excess (HP:0000837)2.64514185
51Progressive cerebellar ataxia (HP:0002073)2.60947790
52Tubular atrophy (HP:0000092)2.60385637
53Abnormal gallbladder physiology (HP:0012438)2.60136725
54Cholecystitis (HP:0001082)2.60136725
55Abnormality of midbrain morphology (HP:0002418)2.51498581
56Molar tooth sign on MRI (HP:0002419)2.51498581
57Insulin-resistant diabetes mellitus (HP:0000831)2.49540418
58Tubulointerstitial abnormality (HP:0001969)2.43415544
59Portal hypertension (HP:0001409)2.41866902
60Abnormality of the costochondral junction (HP:0000919)2.39530093
61Dyschromatopsia (HP:0007641)2.32587204
62Recurrent pneumonia (HP:0006532)2.31097556
63Azoospermia (HP:0000027)2.30430023
64Ventricular tachycardia (HP:0004756)2.26721605
65Choroideremia (HP:0001139)2.25343279
66Spastic tetraparesis (HP:0001285)2.24004625
67Medial flaring of the eyebrow (HP:0010747)2.23301154
68Tetany (HP:0001281)2.23174162
69Abnormality of the hepatic vasculature (HP:0006707)2.20668090
70Abnormality of dental color (HP:0011073)2.16243068
71Transposition of the great arteries (HP:0001669)2.15862674
72Abnormal connection of the cardiac segments (HP:0011545)2.15862674
73Abnormal ventriculo-arterial connection (HP:0011563)2.15862674
74Hyperuricemia (HP:0002149)2.07541236
75Increased purine levels (HP:0004368)2.07541236
76Flattened epiphyses (HP:0003071)2.04651362
77Hyponatremia (HP:0002902)2.03544667
78Tubulointerstitial fibrosis (HP:0005576)2.02273070
79Absent/shortened dynein arms (HP:0200106)13.4599015
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.4599015
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8935758
82Osteomalacia (HP:0002749)1.97621151
83Decreased central vision (HP:0007663)1.96177408
84Myokymia (HP:0002411)1.93852829
85Heterotopia (HP:0002282)1.93110872
86Widely patent fontanelles and sutures (HP:0004492)1.89711358
87Epiphyseal dysplasia (HP:0002656)1.89555856
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89437525
89Neoplasm of the heart (HP:0100544)1.89390358
90Hyperthyroidism (HP:0000836)1.87946089
91Hypophosphatemic rickets (HP:0004912)1.87735201
92Hemorrhage of the eye (HP:0011885)1.85135772
93Abnormality of the epiphysis of the femoral head (HP:0010574)1.84966656
94Abnormality of the pubic bones (HP:0003172)1.84627077
95Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84322904
96Progressive hearing impairment (HP:0001730)1.83895796
97Optic nerve hypoplasia (HP:0000609)1.82510850
98Abnormal drinking behavior (HP:0030082)1.80905958
99Polydipsia (HP:0001959)1.80905958
100Postaxial foot polydactyly (HP:0001830)1.79767308
101Abnormality of chloride homeostasis (HP:0011422)1.78976007
102Amblyopia (HP:0000646)1.78721822
103Stage 5 chronic kidney disease (HP:0003774)1.77657441
104Subcapsular cataract (HP:0000523)1.75477203
105Flat capital femoral epiphysis (HP:0003370)1.75240664
106Bowel incontinence (HP:0002607)1.74782647
107Recurrent corneal erosions (HP:0000495)1.74081103
108Bell-shaped thorax (HP:0001591)1.73400691
109Atelectasis (HP:0100750)1.73245399
110Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.70889314
111Neurofibrillary tangles (HP:0002185)1.68000604
112Congenital hepatic fibrosis (HP:0002612)1.67518254
113Bile duct proliferation (HP:0001408)1.62976217
114Abnormal biliary tract physiology (HP:0012439)1.62976217
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.62313860
116Abnormality of renal excretion (HP:0011036)1.61808956
117Short ribs (HP:0000773)1.60309017
118Abnormality of the renal cortex (HP:0011035)1.60295293
119Oculomotor apraxia (HP:0000657)1.51721648
120Renal dysplasia (HP:0000110)1.50027155
121Abnormality of the lower motor neuron (HP:0002366)1.49970938
122Hemiparesis (HP:0001269)1.48828599
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.45204108
124Absent epiphyses (HP:0010577)1.45204108
125Aplasia/Hypoplasia of the lens (HP:0008063)1.44350612
126Abnormality of dentin (HP:0010299)1.43423189
127Asymmetric septal hypertrophy (HP:0001670)1.41413158
128Fibular hypoplasia (HP:0003038)1.40176907
129Deformed sella turcica (HP:0002681)1.39682606
130Postaxial hand polydactyly (HP:0001162)1.39589503
131Abnormality of the dental root (HP:0006486)1.39346922
132Taurodontia (HP:0000679)1.39346922
133Abnormality of permanent molar morphology (HP:0011071)1.39346922
134Cerebral inclusion bodies (HP:0100314)1.39047078
135Abnormal urine output (HP:0012590)1.38810544
136Facial cleft (HP:0002006)1.38232653
137Double outlet right ventricle (HP:0001719)1.37181508
138Congenital malformation of the right heart (HP:0011723)1.37181508
139Bundle branch block (HP:0011710)1.33606940
140Amyotrophic lateral sclerosis (HP:0007354)1.31565374
141Hypercholesterolemia (HP:0003124)1.30488676
142Easy fatigability (HP:0003388)1.30094986
143Loss of speech (HP:0002371)1.29819663
144Abnormality of the dental pulp (HP:0006479)1.29162985
145Abnormality of molar morphology (HP:0011070)1.28267945
146Abnormality of molar (HP:0011077)1.28267945
147Absent frontal sinuses (HP:0002688)1.26584421
148Cystic liver disease (HP:0006706)1.26203511
149Cerebellar dysplasia (HP:0007033)1.25657468
150Broad distal phalanx of finger (HP:0009836)1.24366039
151Exercise-induced myalgia (HP:0003738)1.23848603
152Short thorax (HP:0010306)1.23293086
153Short femoral neck (HP:0100864)1.22655340
154Chronic sinusitis (HP:0011109)1.22302345
155Nephropathy (HP:0000112)1.21688989
156Truncal obesity (HP:0001956)1.21675478
157Impaired proprioception (HP:0010831)1.20071010
158Myoglobinuria (HP:0002913)1.19965032
159Sensory axonal neuropathy (HP:0003390)1.17538728
160J-shaped sella turcica (HP:0002680)1.16601933
161Retinal dysplasia (HP:0007973)1.15797119
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.14904004
163Fatigable weakness (HP:0003473)1.14194240
164Abnormality of the neuromuscular junction (HP:0003398)1.14194240
165Polyuria (HP:0000103)1.13873441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.43889525
2PDK37.43889525
3TESK17.05735096
4PRKD36.37238516
5ICK4.95156385
6PDK24.80109434
7DDR24.43838769
8MAP4K23.19755398
9INSRR2.68675225
10BRD42.64502790
11PLK22.59143337
12PTK2B2.27985199
13WNK42.06431080
14STK381.98091490
15STK391.95015729
16PNCK1.94284535
17MST1R1.80081015
18DYRK1B1.71211992
19NEK21.65405750
20PIK3CG1.28465229
21AKT31.26357049
22CDK71.25885039
23KSR21.19983319
24MAP3K91.16842510
25PDK11.15104203
26SIK21.13637452
27DYRK30.93473913
28TYRO30.92695126
29MAPK150.90531084
30CAMK1D0.85750470
31WNK10.80503251
32PASK0.79899303
33MAP3K20.76191999
34PDPK10.75972825
35TESK20.74876414
36MAP3K110.74046328
37MAP2K20.71958359
38RIPK40.68788217
39IRAK10.66807500
40LATS20.65481696
41STK30.65297208
42RPS6KA20.65268090
43GRK10.64980265
44SGK4940.64905817
45SGK2230.64905817
46LATS10.63601199
47EEF2K0.63497606
48UHMK10.62137337
49CCNB10.60353007
50CAMK1G0.60269677
51MAP3K80.59722557
52ROCK10.59366493
53TTK0.59033364
54CAMK10.57754896
55ZAK0.56595162
56ACVR1B0.54854193
57CHEK20.54625900
58MAP2K60.54443950
59PINK10.53036929
60PRKAA20.50446568
61PAK10.44885057
62MUSK0.44860776
63CDK30.42980955
64MAPK10.41907837
65IRAK20.41512388
66NTRK20.41107585
67LMTK20.37815491
68SGK10.36448517
69CHEK10.36131801
70RIPK10.35397315
71PAK20.34791754
72ARAF0.33236978
73CAMK40.32859489
74STK38L0.32542923
75PRKCG0.31773718
76MAP3K100.31056202
77MTOR0.30623524
78RPS6KC10.30334030
79RPS6KL10.30334030
80PAK40.29778755
81MARK20.29729014
82NTRK30.29059099
83RPS6KA60.28613654
84CAMKK10.28527867
85ATM0.26244953
86TLK10.25507300
87MET0.25172830
88MAPKAPK50.24737734
89MAPK140.24663353
90ATR0.23287228
91MAPK100.22230730
92MARK10.21758525
93PRKAA10.21588967
94TIE10.21510814
95MAP3K130.20566647
96NEK60.19240236
97WEE10.17148985
98RPS6KB10.17032888
99PRKCZ0.15522313
100MAPK110.14828369
101MINK10.14466580
102TRPM70.14276223
103AKT10.11800229
104PRKCQ0.11691785
105CDK150.11579556
106SGK20.11295897
107BRSK20.09747552
108CDC70.09360417
109PRKACA0.09094147
110PLK10.09091403
111RPS6KA10.09080088
112CDK180.09040265
113CDK11A0.07820941
114PLK40.07517222
115PRKACB0.07264277
116FER0.06861396
117MAPK90.06407688
118CDK60.06390092
119GSK3B0.06028709
120BRSK10.05642811
121STK110.05208730
122CDK140.04765196
123CSNK2A10.04555243
124PRKG20.04392823
125TRIB30.04350068
126CSNK1D0.04057395
127BMPR1B0.03832564
128CLK10.03756943
129CSF1R0.03662779
130STK100.03190426
131PAK60.02593165
132CDK20.02012076
133CAMK2A0.01956337
134PIM10.01940150
135TAOK10.01938324
136PRKACG0.01921408
137PRKG10.01888618
138BRAF0.01585411
139CDK10.01056946
140MAPK80.00943895
141EPHB10.00702729
142PRKCB0.00660154
143PRKCD0.00592340
144MARK30.00417836
145ZAP700.00242353
146PKN10.00087611
147CDK40.00013791
148PDGFRB-0.0328513
149RPS6KA3-0.0268647
150AURKA-0.0207692
151MAP3K1-0.0174179
152CSNK2A2-0.0118084
153PRKCA-0.0108950
154CDK12-0.0053366
155EGFR-0.0010013

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.84828513
2Fatty acid biosynthesis_Homo sapiens_hsa000614.75332603
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.40675797
4Vitamin B6 metabolism_Homo sapiens_hsa007503.51779253
5Pyruvate metabolism_Homo sapiens_hsa006203.37178872
6Olfactory transduction_Homo sapiens_hsa047403.10030550
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09324752
8Linoleic acid metabolism_Homo sapiens_hsa005912.97387293
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.71650656
10Butanoate metabolism_Homo sapiens_hsa006502.67480876
11Propanoate metabolism_Homo sapiens_hsa006402.60602127
12Glucagon signaling pathway_Homo sapiens_hsa049222.57514887
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.49162482
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.46290673
15Glycerolipid metabolism_Homo sapiens_hsa005612.07014356
16Basal transcription factors_Homo sapiens_hsa030222.05463783
17Selenocompound metabolism_Homo sapiens_hsa004502.04096746
18PPAR signaling pathway_Homo sapiens_hsa033202.01063764
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.80580875
20Dorso-ventral axis formation_Homo sapiens_hsa043201.77197193
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.74594137
22Fructose and mannose metabolism_Homo sapiens_hsa000511.69556757
23* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68412835
24Phototransduction_Homo sapiens_hsa047441.67718126
25Oocyte meiosis_Homo sapiens_hsa041141.64345670
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.62166273
27Amphetamine addiction_Homo sapiens_hsa050311.60051626
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55187469
29Fatty acid metabolism_Homo sapiens_hsa012121.52084192
30Fatty acid degradation_Homo sapiens_hsa000711.51383278
31Pentose phosphate pathway_Homo sapiens_hsa000301.49879644
32Fat digestion and absorption_Homo sapiens_hsa049751.47965621
33Mineral absorption_Homo sapiens_hsa049781.42433187
34Ether lipid metabolism_Homo sapiens_hsa005651.37633055
35Type I diabetes mellitus_Homo sapiens_hsa049401.37589784
36Allograft rejection_Homo sapiens_hsa053301.33151359
37Autoimmune thyroid disease_Homo sapiens_hsa053201.30610866
38Carbon metabolism_Homo sapiens_hsa012001.30067566
39Phenylalanine metabolism_Homo sapiens_hsa003601.29074417
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.27885118
41Cardiac muscle contraction_Homo sapiens_hsa042601.25958059
42Fanconi anemia pathway_Homo sapiens_hsa034601.19005186
43Graft-versus-host disease_Homo sapiens_hsa053321.18616734
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.16462767
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14142460
46Renin secretion_Homo sapiens_hsa049241.13564071
47Arginine and proline metabolism_Homo sapiens_hsa003301.12029960
48Antigen processing and presentation_Homo sapiens_hsa046121.07738393
49mRNA surveillance pathway_Homo sapiens_hsa030150.99268749
50Morphine addiction_Homo sapiens_hsa050320.95277721
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93341581
52RNA transport_Homo sapiens_hsa030130.92976415
53Hedgehog signaling pathway_Homo sapiens_hsa043400.92126807
54Glutathione metabolism_Homo sapiens_hsa004800.92076591
55Purine metabolism_Homo sapiens_hsa002300.90904232
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.90713481
57Huntingtons disease_Homo sapiens_hsa050160.89456366
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87644640
59Viral myocarditis_Homo sapiens_hsa054160.87393875
60Insulin secretion_Homo sapiens_hsa049110.82929769
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82446920
62Long-term potentiation_Homo sapiens_hsa047200.82169531
63Collecting duct acid secretion_Homo sapiens_hsa049660.81787572
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81430896
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79449897
66Biosynthesis of amino acids_Homo sapiens_hsa012300.79228779
67Arachidonic acid metabolism_Homo sapiens_hsa005900.76870216
68Arginine biosynthesis_Homo sapiens_hsa002200.76216031
69Estrogen signaling pathway_Homo sapiens_hsa049150.75952129
70Bile secretion_Homo sapiens_hsa049760.75049990
71Chemical carcinogenesis_Homo sapiens_hsa052040.73501150
72Thyroid hormone synthesis_Homo sapiens_hsa049180.72561790
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70426956
74Systemic lupus erythematosus_Homo sapiens_hsa053220.69690186
75Influenza A_Homo sapiens_hsa051640.66684975
76Nitrogen metabolism_Homo sapiens_hsa009100.66235659
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65779399
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.62244528
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60899716
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.60854743
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60798148
82Legionellosis_Homo sapiens_hsa051340.58240941
83ABC transporters_Homo sapiens_hsa020100.56016124
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55110067
85Renin-angiotensin system_Homo sapiens_hsa046140.54473729
86Tyrosine metabolism_Homo sapiens_hsa003500.54425384
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53137520
88Calcium signaling pathway_Homo sapiens_hsa040200.52340541
89Endocytosis_Homo sapiens_hsa041440.50927112
90Pancreatic secretion_Homo sapiens_hsa049720.50819842
91Nicotine addiction_Homo sapiens_hsa050330.50142608
92AMPK signaling pathway_Homo sapiens_hsa041520.50055757
93Salivary secretion_Homo sapiens_hsa049700.49962043
94Glutamatergic synapse_Homo sapiens_hsa047240.49181237
95Retinol metabolism_Homo sapiens_hsa008300.47774147
96Protein digestion and absorption_Homo sapiens_hsa049740.47463925
97MAPK signaling pathway_Homo sapiens_hsa040100.46265626
98Tight junction_Homo sapiens_hsa045300.45520018
99Synaptic vesicle cycle_Homo sapiens_hsa047210.44542989
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.44215192
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41132786
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40846142
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.40508260
104Acute myeloid leukemia_Homo sapiens_hsa052210.40386914
105Gastric acid secretion_Homo sapiens_hsa049710.40273434
106Alcoholism_Homo sapiens_hsa050340.40187450
107VEGF signaling pathway_Homo sapiens_hsa043700.39986946
108Inositol phosphate metabolism_Homo sapiens_hsa005620.39727767
109Taste transduction_Homo sapiens_hsa047420.39601608
110Serotonergic synapse_Homo sapiens_hsa047260.37989106
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37852286
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36923314
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36268180
114Cholinergic synapse_Homo sapiens_hsa047250.35722699
115Sulfur metabolism_Homo sapiens_hsa009200.33496911
116cAMP signaling pathway_Homo sapiens_hsa040240.32871549
117Metabolic pathways_Homo sapiens_hsa011000.32639253
118Circadian entrainment_Homo sapiens_hsa047130.32572285
119Cocaine addiction_Homo sapiens_hsa050300.29052685
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28670464
121GABAergic synapse_Homo sapiens_hsa047270.28142559
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26885944
123Oxytocin signaling pathway_Homo sapiens_hsa049210.25030757
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22996375
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18275795
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18185952
127Pyrimidine metabolism_Homo sapiens_hsa002400.17481238
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.17130351
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16616831
130Basal cell carcinoma_Homo sapiens_hsa052170.15439157
131Circadian rhythm_Homo sapiens_hsa047100.15343819
132B cell receptor signaling pathway_Homo sapiens_hsa046620.13983072
133Peroxisome_Homo sapiens_hsa041460.13902332
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.13860046
135Chemokine signaling pathway_Homo sapiens_hsa040620.12012462
136Viral carcinogenesis_Homo sapiens_hsa052030.10880321
137HIF-1 signaling pathway_Homo sapiens_hsa040660.10237178
138Type II diabetes mellitus_Homo sapiens_hsa049300.10143622
139Wnt signaling pathway_Homo sapiens_hsa043100.09878584
140Insulin resistance_Homo sapiens_hsa049310.09816554

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