ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of mitochondrial translation (GO:0070129)	7.40035571
2	adaptation of signaling pathway (GO:0023058)	7.02232534
3	base-excision repair, AP site formation (GO:0006285)	6.42966569
4	positive regulation of fatty acid beta-oxidation (GO:0032000)	6.30605937
5	regulation of fatty acid beta-oxidation (GO:0031998)	6.24122300
6	pseudouridine synthesis (GO:0001522)	5.74763000
7	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.60730671
8	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	5.47047949
9	negative regulation of membrane potential (GO:0045837)	5.45007041
10	positive regulation of endothelial cell differentiation (GO:0045603)	5.44004973
11	water-soluble vitamin biosynthetic process (GO:0042364)	5.38182105
12	protein K48-linked deubiquitination (GO:0071108)	5.21985702
13	negative regulation of DNA-templated transcription, elongation (GO:0032785)	5.08816128
14	kidney mesenchyme development (GO:0072074)	4.86431871
15	pyrimidine nucleotide catabolic process (GO:0006244)	4.79955693
16	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	4.74758246
17	positive regulation of triglyceride biosynthetic process (GO:0010867)	4.69400067
18	histone deubiquitination (GO:0016578)	4.54706023
19	mitochondrial respiratory chain complex assembly (GO:0033108)	4.54650142
20	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.54329328
21	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.26829310
22	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	4.24207734
23	cysteine metabolic process (GO:0006534)	4.16043768
24	protein complex biogenesis (GO:0070271)	4.10107118
25	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.85544710
26	histone H2A monoubiquitination (GO:0035518)	3.74227260
27	protein localization to peroxisome (GO:0072662)	3.71626932
28	protein targeting to peroxisome (GO:0006625)	3.71626932
29	establishment of protein localization to peroxisome (GO:0072663)	3.71626932
30	mitochondrial RNA metabolic process (GO:0000959)	3.64903340
31	lung secretory cell differentiation (GO:0061140)	3.64274709
32	protein import into peroxisome matrix (GO:0016558)	3.63916963
33	positive regulation of fatty acid oxidation (GO:0046321)	3.63422133
34	adenine nucleotide transport (GO:0051503)	3.62882146
35	L-serine transport (GO:0015825)	3.59291218
36	peroxisomal transport (GO:0043574)	3.53081146
37	serine transport (GO:0032329)	3.50564222
38	regulation of endothelial cell differentiation (GO:0045601)	3.50192693
39	purine ribonucleotide transport (GO:0015868)	3.40516236
40	vitamin biosynthetic process (GO:0009110)	3.38390183
41	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	3.35838300
42	regulation of triglyceride biosynthetic process (GO:0010866)	3.35324299
43	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	3.35078327
44	deoxyribonucleotide catabolic process (GO:0009264)	3.33666735
45	protein neddylation (GO:0045116)	3.32719067
46	dopaminergic neuron differentiation (GO:0071542)	3.31504052
47	cobalamin metabolic process (GO:0009235)	3.21506307
48	negative regulation of cell aging (GO:0090344)	3.21244331
49	pattern specification involved in kidney development (GO:0061004)	3.18723040
50	deoxyribose phosphate catabolic process (GO:0046386)	3.14187124
51	protein-cofactor linkage (GO:0018065)	3.10548466
52	response to gravity (GO:0009629)	3.07402302
53	behavioral response to nicotine (GO:0035095)	3.06539935
54	regulation of activin receptor signaling pathway (GO:0032925)	3.05575451
55	regulation of NFAT protein import into nucleus (GO:0051532)	3.01010137
56	metanephric mesenchyme development (GO:0072075)	2.98195461
57	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.96097911
58	positive regulation of histone deacetylation (GO:0031065)	2.96020648
59	transcription from mitochondrial promoter (GO:0006390)	2.93057533
60	embryonic skeletal joint morphogenesis (GO:0060272)	2.88528084
61	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	2.88171468
62	regulation of histone phosphorylation (GO:0033127)	2.87120458
63	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.86560137
64	primary amino compound metabolic process (GO:1901160)	2.86136816
65	serotonin metabolic process (GO:0042428)	2.85875247
66	cholesterol biosynthetic process (GO:0006695)	2.83046612
67	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.80278598
68	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.80278598
69	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.78103384
70	L-phenylalanine metabolic process (GO:0006558)	2.78103384
71	positive regulation of receptor biosynthetic process (GO:0010870)	2.77976125
72	purine nucleotide transport (GO:0015865)	2.75661318
73	histone H2A ubiquitination (GO:0033522)	2.75219306
74	regulation of translational fidelity (GO:0006450)	2.75173522
75	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.72458714
76	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.72239242
77	retinal ganglion cell axon guidance (GO:0031290)	2.65748362
78	positive regulation of triglyceride metabolic process (GO:0090208)	2.65381047
79	maturation of 5.8S rRNA (GO:0000460)	2.64196459
80	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.62785666
81	regulation of cardioblast proliferation (GO:0003264)	2.62785666
82	regulation of sequestering of triglyceride (GO:0010889)	2.62098524
83	sulfur amino acid catabolic process (GO:0000098)	2.61608617
84	sequestering of actin monomers (GO:0042989)	2.61499090
85	resolution of meiotic recombination intermediates (GO:0000712)	2.61323869
86	cochlea morphogenesis (GO:0090103)	2.60948887
87	L-phenylalanine catabolic process (GO:0006559)	2.60267760
88	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.60267760
89	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.60144805
90	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.60144805
91	NADH dehydrogenase complex assembly (GO:0010257)	2.60144805
92	negative regulation of phagocytosis (GO:0050765)	2.60089406
93	negative regulation of glycogen biosynthetic process (GO:0045719)	2.60023970
94	regulation of fatty acid oxidation (GO:0046320)	2.58743716
95	cytochrome complex assembly (GO:0017004)	2.57599267
96	activation of MAPKKK activity (GO:0000185)	2.54753407
97	homocysteine metabolic process (GO:0050667)	2.52347584
98	tRNA methylation (GO:0030488)	2.52135356
99	establishment of planar polarity (GO:0001736)	2.51297740
100	monoubiquitinated protein deubiquitination (GO:0035520)	12.5414112

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.75858037
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.59765440
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.44258207
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.39569434
5	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.91108424
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.81490267
7	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.64033716
8	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.62739011
9	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.60002818
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.59041284
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.50912246
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.50073154
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.49653743
14	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.48290230
15	MYC_22102868_ChIP-Seq_BL_Human	2.38032886
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.26364682
17	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.08900314
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.08069376
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.07618518
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.07233539
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.06316792
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.06185358
23	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.02395381
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.01862876
25	CIITA_25753668_ChIP-Seq_RAJI_Human	1.98023498
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.95716861
27	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.94176898
28	GABP_19822575_ChIP-Seq_HepG2_Human	1.92599389
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.91937904
30	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.87829570
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.85546191
32	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.83781860
33	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.82138802
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.76053188
35	VDR_21846776_ChIP-Seq_THP-1_Human	1.74973677
36	DCP1A_22483619_ChIP-Seq_HELA_Human	1.71706670
37	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.68592056
38	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.68194086
39	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.64697960
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.63824129
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.63600499
42	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.61668357
43	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.60983746
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.57777620
45	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.57657633
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55120414
47	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.54026134
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.53357854
49	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.47191017
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.46489816
51	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.45752736
52	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.45379069
53	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.40012359
54	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.39927493
55	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.38623490
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.38112849
57	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.36813253
58	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.36107318
59	TP53_22127205_ChIP-Seq_IMR90_Human	1.35851181
60	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.32384307
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.31786076
62	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.29667181
63	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27119910
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.24831147
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.24180965
66	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.24007107
67	P68_20966046_ChIP-Seq_HELA_Human	1.22200041
68	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.22076810
69	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20805777
70	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.20787893
71	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.16989750
72	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.16526310
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.15652654
74	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.14569492
75	LXR_22292898_ChIP-Seq_THP-1_Human	1.14132209
76	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.12782370
77	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.12036975
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11537481
79	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.09739571
80	ZNF263_19887448_ChIP-Seq_K562_Human	1.09524840
81	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.08580581
82	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.06336978
83	RACK7_27058665_Chip-Seq_MCF-7_Human	1.05328885
84	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.04580532
85	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.03640032
86	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.03230498
87	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.02671132
88	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.02608085
89	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02331873
90	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.98585496
91	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.97591451
92	ZNF274_21170338_ChIP-Seq_K562_Hela	0.97486784
93	BCL6_27268052_Chip-Seq_Bcells_Human	0.95629952
94	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.94299881
95	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.94239825
96	TFEB_21752829_ChIP-Seq_HELA_Human	0.93011933
97	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.91709119
98	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.91347398
99	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.90564341
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.89816902

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	7.87345066
2	MP0002837_dystrophic_cardiac_calcinosis	4.65746214
3	MP0003122_maternal_imprinting	4.54827371
4	MP0002736_abnormal_nociception_after	4.08509867
5	MP0003011_delayed_dark_adaptation	3.15668464
6	MP0004185_abnormal_adipocyte_glucose	2.85949695
7	MP0000537_abnormal_urethra_morphology	2.84877831
8	MP0003123_paternal_imprinting	2.77094805
9	MP0001905_abnormal_dopamine_level	2.60781495
10	MP0001529_abnormal_vocalization	2.59984746
11	MP0004742_abnormal_vestibular_system	2.51797678
12	MP0001968_abnormal_touch/_nociception	2.51053823
13	MP0003121_genomic_imprinting	2.45115065
14	MP0005645_abnormal_hypothalamus_physiol	2.30747882
15	MP0003890_abnormal_embryonic-extraembry	2.26349699
16	MP0010030_abnormal_orbit_morphology	2.25455425
17	MP0002735_abnormal_chemical_nociception	1.99480632
18	MP0000534_abnormal_ureter_morphology	1.94128770
19	MP0005670_abnormal_white_adipose	1.92305531
20	MP0009384_cardiac_valve_regurgitation	1.89888117
21	MP0000049_abnormal_middle_ear	1.84918689
22	MP0001853_heart_inflammation	1.83256452
23	MP0004133_heterotaxia	1.75452496
24	MP0008775_abnormal_heart_ventricle	1.73633051
25	MP0001346_abnormal_lacrimal_gland	1.64611012
26	MP0003942_abnormal_urinary_system	1.59220260
27	MP0002249_abnormal_larynx_morphology	1.56419132
28	MP0000678_abnormal_parathyroid_gland	1.55974125
29	MP0001270_distended_abdomen	1.53161083
30	MP0001727_abnormal_embryo_implantation	1.46221198
31	MP0008789_abnormal_olfactory_epithelium	1.43554625
32	MP0005367_renal/urinary_system_phenotyp	1.42262452
33	MP0000516_abnormal_urinary_system	1.42262452
34	MP0000343_altered_response_to	1.36772176
35	MP0002277_abnormal_respiratory_mucosa	1.32945455
36	MP0010234_abnormal_vibrissa_follicle	1.30126314
37	MP0002102_abnormal_ear_morphology	1.27805565
38	MP0005666_abnormal_adipose_tissue	1.24464634
39	MP0001188_hyperpigmentation	1.22450882
40	MP0003755_abnormal_palate_morphology	1.18720953
41	MP0005058_abnormal_lysosome_morphology	1.14804289
42	MP0000751_myopathy	1.13896566
43	MP0001661_extended_life_span	1.10849753
44	MP0000778_abnormal_nervous_system	1.10794571
45	MP0002282_abnormal_trachea_morphology	1.06024326
46	MP0000026_abnormal_inner_ear	1.02658369
47	MP0001666_abnormal_nutrient_absorption	1.01754670
48	MP0003111_abnormal_nucleus_morphology	1.01283804
49	MP0002938_white_spotting	0.97851864
50	MP0003077_abnormal_cell_cycle	0.97557021
51	MP0000538_abnormal_urinary_bladder	0.96843709
52	MP0000681_abnormal_thyroid_gland	0.95621098
53	MP0003937_abnormal_limbs/digits/tail_de	0.95359729
54	MP0010094_abnormal_chromosome_stability	0.95231179
55	MP0002822_catalepsy	0.94358160
56	MP0005386_behavior/neurological_phenoty	0.92966677
57	MP0004924_abnormal_behavior	0.92966677
58	MP0002751_abnormal_autonomic_nervous	0.88826858
59	MP0009046_muscle_twitch	0.87997948
60	MP0003786_premature_aging	0.78948228
61	MP0008058_abnormal_DNA_repair	0.78630005
62	MP0004130_abnormal_muscle_cell	0.78518835
63	MP0002557_abnormal_social/conspecific_i	0.78142542
64	MP0004233_abnormal_muscle_weight	0.77956820
65	MP0003183_abnormal_peptide_metabolism	0.74220395
66	MP0009780_abnormal_chondrocyte_physiolo	0.68361729
67	MP0000631_abnormal_neuroendocrine_gland	0.67758976
68	MP0003938_abnormal_ear_development	0.65829919
69	MP0002116_abnormal_craniofacial_bone	0.63578784
70	MP0009764_decreased_sensitivity_to	0.63549390
71	MP0008875_abnormal_xenobiotic_pharmacok	0.63330817
72	MP0001340_abnormal_eyelid_morphology	0.63203105
73	MP0002932_abnormal_joint_morphology	0.63114119
74	MP0008007_abnormal_cellular_replicative	0.62782428
75	MP0005332_abnormal_amino_acid	0.62392697
76	MP0004782_abnormal_surfactant_physiolog	0.61690586
77	MP0002177_abnormal_outer_ear	0.59596278
78	MP0001963_abnormal_hearing_physiology	0.59341212
79	MP0001730_embryonic_growth_arrest	0.54450932
80	MP0003718_maternal_effect	0.54008718
81	MP0001502_abnormal_circadian_rhythm	0.52687731
82	MP0001849_ear_inflammation	0.51746645
83	MP0005220_abnormal_exocrine_pancreas	0.51516249
84	MP0003221_abnormal_cardiomyocyte_apopto	0.51403207
85	MP0002160_abnormal_reproductive_system	0.51345644
86	MP0009053_abnormal_anal_canal	0.50621139
87	MP0003699_abnormal_female_reproductive	0.49389403
88	MP0003329_amyloid_beta_deposits	0.49351240
89	MP0005410_abnormal_fertilization	0.48926120
90	MP0005266_abnormal_metabolism	0.48857191
91	MP0005375_adipose_tissue_phenotype	0.47904437
92	MP0002928_abnormal_bile_duct	0.47166278
93	MP0002272_abnormal_nervous_system	0.47083585
94	MP0002572_abnormal_emotion/affect_behav	0.46518690
95	MP0005408_hypopigmentation	0.46027747
96	MP0001944_abnormal_pancreas_morphology	0.45328701
97	MP0003693_abnormal_embryo_hatching	0.44996273
98	MP0003861_abnormal_nervous_system	0.43580241
99	MP0001324_abnormal_eye_pigmentation	0.42691439
100	MP0002067_abnormal_sensory_capabilities	0.42107777

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Meningioma (HP:0002858)	6.93630440
2	Hyperglycinemia (HP:0002154)	6.42434285
3	Methylmalonic aciduria (HP:0012120)	5.52856415
4	Methylmalonic acidemia (HP:0002912)	5.39913856
5	Melanoma (HP:0002861)	4.43064196
6	Asymmetry of the thorax (HP:0001555)	4.11353824
7	Neoplasm of the lung (HP:0100526)	3.53446644
8	Lymphangioma (HP:0100764)	3.49930820
9	Benign neoplasm of the central nervous system (HP:0100835)	3.34666227
10	Neoplasm of the respiratory system (HP:0100606)	3.26511282
11	Abnormality of glycine metabolism (HP:0010895)	3.23375058
12	Abnormality of serine family amino acid metabolism (HP:0010894)	3.23375058
13	Small epiphyses (HP:0010585)	3.08805311
14	Progressive sensorineural hearing impairment (HP:0000408)	3.00847099
15	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.93590356
16	Dicarboxylic aciduria (HP:0003215)	2.93590356
17	Squamous cell carcinoma (HP:0002860)	2.92072806
18	Neonatal onset (HP:0003623)	2.78313861
19	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.57847438
20	Short nail (HP:0001799)	2.54708868
21	Back pain (HP:0003418)	2.52836319
22	Delayed epiphyseal ossification (HP:0002663)	2.51382520
23	Ulnar deviation of the wrist (HP:0003049)	2.51303401
24	Neoplasm of the adrenal gland (HP:0100631)	2.48122909
25	Ureteral duplication (HP:0000073)	2.43163506
26	Subacute progressive viral hepatitis (HP:0006572)	2.42550665
27	Amblyopia (HP:0000646)	2.29489580
28	Anxiety (HP:0000739)	2.26284928
29	Abnormality of vitamin B metabolism (HP:0004340)	2.21538176
30	Congenital, generalized hypertrichosis (HP:0004540)	2.21157424
31	Rough bone trabeculation (HP:0100670)	2.19821271
32	Abdominal distention (HP:0003270)	2.16149714
33	Neoplasm of the adrenal cortex (HP:0100641)	2.14508087
34	Torticollis (HP:0000473)	2.13609379
35	Sparse eyelashes (HP:0000653)	2.13061132
36	Progressive inability to walk (HP:0002505)	2.08623620
37	Type I transferrin isoform profile (HP:0003642)	2.06753604
38	Respiratory distress (HP:0002098)	2.06057780
39	Intestinal atresia (HP:0011100)	2.05000083
40	Cortical dysplasia (HP:0002539)	2.04829135
41	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.00711215
42	Cutaneous melanoma (HP:0012056)	16.0176276
43	Hyperkalemia (HP:0002153)	1.99469365
44	Carpal bone hypoplasia (HP:0001498)	1.99037059
45	Irregular vertebral endplates (HP:0003301)	1.98990960
46	Exostoses (HP:0100777)	1.98279135
47	Obsessive-compulsive behavior (HP:0000722)	1.97184245
48	Abnormal trabecular bone morphology (HP:0100671)	1.94635258
49	Hyperammonemia (HP:0001987)	1.92082035
50	Viral hepatitis (HP:0006562)	1.89909048
51	Abnormality of glycolysis (HP:0004366)	1.89443231
52	Abnormality of the parathyroid morphology (HP:0011766)	1.87827756
53	Hyperacusis (HP:0010780)	1.86584827
54	Rhabdomyolysis (HP:0003201)	1.83133231
55	Increased hepatocellular lipid droplets (HP:0006565)	1.81905779
56	Craniofacial dystonia (HP:0012179)	1.80998291
57	Achilles tendon contracture (HP:0001771)	1.79889907
58	Abnormal protein N-linked glycosylation (HP:0012347)	1.78444918
59	Abnormal protein glycosylation (HP:0012346)	1.78444918
60	Abnormal glycosylation (HP:0012345)	1.78444918
61	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78444918
62	Abnormality of the line of Schwalbe (HP:0008048)	1.77708296
63	Incomplete penetrance (HP:0003829)	1.77630679
64	Insomnia (HP:0100785)	1.75749130
65	Large eyes (HP:0001090)	1.73221172
66	Hypokinesia (HP:0002375)	1.72735485
67	Abnormality of the Achilles tendon (HP:0005109)	1.71006058
68	Increased serum pyruvate (HP:0003542)	1.70652623
69	Natal tooth (HP:0000695)	1.69847638
70	Increased nuchal translucency (HP:0010880)	1.69306629
71	Lipid accumulation in hepatocytes (HP:0006561)	1.69129415
72	Short femoral neck (HP:0100864)	1.69024950
73	Focal dystonia (HP:0004373)	1.68787939
74	Sparse scalp hair (HP:0002209)	1.68745419
75	Septate vagina (HP:0001153)	1.68642732
76	Patellar aplasia (HP:0006443)	1.67806856
77	Long palpebral fissure (HP:0000637)	1.67246051
78	Congenital glaucoma (HP:0001087)	1.67044752
79	Overlapping toe (HP:0001845)	1.65557608
80	Abnormality of vitamin metabolism (HP:0100508)	1.64990917
81	Pancytopenia (HP:0001876)	1.64889564
82	Increased intramyocellular lipid droplets (HP:0012240)	1.64847099
83	Abnormality of serum amino acid levels (HP:0003112)	1.64398497
84	Gastrointestinal stroma tumor (HP:0100723)	1.61026386
85	Corneal erosion (HP:0200020)	1.59811028
86	Abnormality of the vertebral endplates (HP:0005106)	1.59667998
87	Breast hypoplasia (HP:0003187)	1.58964423
88	Renal Fanconi syndrome (HP:0001994)	1.58892724
89	Supernumerary nipples (HP:0002558)	1.57744813
90	Abnormal epiphyseal ossification (HP:0010656)	1.57401054
91	Neurodegeneration (HP:0002180)	1.57348341
92	Hepatitis (HP:0012115)	1.55079506
93	Progressive microcephaly (HP:0000253)	1.54619970
94	Agammaglobulinemia (HP:0004432)	1.54446622
95	Aplasia/Hypoplasia of the patella (HP:0006498)	1.54101072
96	Diminished movement (HP:0002374)	1.53862867
97	Bicornuate uterus (HP:0000813)	1.53440938
98	Upper limb muscle weakness (HP:0003484)	1.53302090
99	Progressive hearing impairment (HP:0001730)	1.52691069
100	Overriding aorta (HP:0002623)	1.52208607

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K10	3.63830292
2	MAP3K13	3.41154005
3	BCKDK	3.28526453
4	TLK1	3.22233739
5	VRK1	3.01128213
6	ICK	2.75501268
7	FRK	2.73580993
8	EPHB2	2.51740587
9	TSSK6	2.48721110
10	ZAK	2.29694122
11	FGFR2	2.17750526
12	CDC7	2.11724834
13	NEK9	2.11045949
14	PBK	2.01399727
15	SMG1	1.93339698
16	CDK12	1.83111355
17	MAPK13	1.81530747
18	MARK1	1.79469885
19	CSNK1G3	1.74038629
20	VRK2	1.66497200
21	AURKA	1.64639927
22	DYRK3	1.63762807
23	MAP3K14	1.59242008
24	DYRK2	1.58381456
25	BCR	1.56846801
26	TRIB3	1.46915086
27	WNK4	1.46226651
28	CSNK1A1L	1.43626283
29	TRIM28	1.40543496
30	CSNK1G2	1.26740451
31	NEK2	1.20589159
32	PRKD2	1.18542635
33	PASK	1.16029900
34	EEF2K	1.15680002
35	DAPK3	1.14245651
36	MAPKAPK5	1.13064913
37	EIF2AK1	1.11913950
38	PIM2	1.09844928
39	MAP2K7	1.09304664
40	CDK7	1.09220309
41	LATS2	1.04994178
42	PLK1	1.02962312
43	RPS6KA5	1.02685841
44	SIK1	1.01134083
45	SRPK1	0.98223475
46	IRAK3	0.97457013
47	MAP3K7	0.95319490
48	PRKD3	0.95201346
49	PLK3	0.94510942
50	LRRK2	0.93818277
51	MST1R	0.89837281
52	TESK1	0.89427364
53	IRAK2	0.88671901
54	CSNK1G1	0.87230169
55	PKN1	0.84340765
56	IKBKB	0.81174806
57	WNK1	0.79915178
58	CHUK	0.72720491
59	MAPKAPK3	0.70255538
60	PRKCZ	0.69880047
61	STK16	0.69062729
62	DYRK1B	0.68925004
63	SIK3	0.68074498
64	ATR	0.66254161
65	ILK	0.65333811
66	SIK2	0.61269263
67	CHEK2	0.60809334
68	MAPK15	0.58759825
69	BUB1	0.58747756
70	AURKB	0.56584274
71	CSNK1A1	0.56299343
72	STK4	0.55350255
73	EPHA2	0.55144718
74	UHMK1	0.53645810
75	TGFBR1	0.52252161
76	MET	0.51708643
77	TAOK2	0.49286036
78	NEK1	0.48752107
79	CDK14	0.48512386
80	NTRK1	0.48150621
81	MAPK4	0.46457774
82	CDK18	0.43454807
83	MAP3K11	0.40985699
84	TAOK1	0.40602009
85	WEE1	0.40454702
86	CDK15	0.40133508
87	ROCK2	0.39780802
88	SGK1	0.39703836
89	RPS6KA4	0.39071199
90	CDK11A	0.36676548
91	MTOR	0.36265662
92	ROCK1	0.35531530
93	NME2	0.34992531
94	IRAK4	0.34847453
95	TAF1	0.34062096
96	CSNK1D	0.34037492
97	PRKCQ	0.33376731
98	ADRBK1	0.33194555
99	NTRK2	0.32987814
100	PKN2	0.31354631

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	5.08397200
2	Steroid biosynthesis_Homo sapiens_hsa00100	4.01770952
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.98433057
4	Sulfur metabolism_Homo sapiens_hsa00920	3.49175799
5	Alcoholism_Homo sapiens_hsa05034	3.38778561
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.05455054
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.99232547
8	Base excision repair_Homo sapiens_hsa03410	2.90394757
9	DNA replication_Homo sapiens_hsa03030	2.77124549
10	Spliceosome_Homo sapiens_hsa03040	2.47222623
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.44228759
12	Sulfur relay system_Homo sapiens_hsa04122	2.37289357
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.27533178
14	Basal transcription factors_Homo sapiens_hsa03022	1.95704396
15	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.64657708
16	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.63435271
17	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.62077659
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.57909845
19	Ribosome_Homo sapiens_hsa03010	1.40964030
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.37503259
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37212539
22	Basal cell carcinoma_Homo sapiens_hsa05217	1.34279113
23	Viral carcinogenesis_Homo sapiens_hsa05203	1.31102427
24	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.28848092
25	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.28435029
26	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.28292914
27	Folate biosynthesis_Homo sapiens_hsa00790	1.27096539
28	Proteasome_Homo sapiens_hsa03050	1.24683573
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.23231249
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21209836
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19911095
32	Type II diabetes mellitus_Homo sapiens_hsa04930	1.14475387
33	Oxidative phosphorylation_Homo sapiens_hsa00190	0.97228276
34	Peroxisome_Homo sapiens_hsa04146	0.96856757
35	Hippo signaling pathway_Homo sapiens_hsa04390	0.93430639
36	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.92759748
37	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.91257749
38	RNA degradation_Homo sapiens_hsa03018	0.88428234
39	Cell cycle_Homo sapiens_hsa04110	0.85139697
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81384370
41	Mismatch repair_Homo sapiens_hsa03430	0.79358958
42	Parkinsons disease_Homo sapiens_hsa05012	0.78736468
43	Butanoate metabolism_Homo sapiens_hsa00650	0.78630767
44	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.76328962
45	mRNA surveillance pathway_Homo sapiens_hsa03015	0.75881862
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71919695
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71415508
48	Glutathione metabolism_Homo sapiens_hsa00480	0.70723683
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70093777
50	Endometrial cancer_Homo sapiens_hsa05213	0.69913149
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67729365
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67581686
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66840958
54	Homologous recombination_Homo sapiens_hsa03440	0.65590711
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64758023
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.61327322
57	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.59575396
58	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.59156556
59	p53 signaling pathway_Homo sapiens_hsa04115	0.59029119
60	RNA polymerase_Homo sapiens_hsa03020	0.58740950
61	Phenylalanine metabolism_Homo sapiens_hsa00360	0.56866267
62	Carbon metabolism_Homo sapiens_hsa01200	0.54116549
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.53010086
64	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.52874699
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.52429190
66	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51413459
67	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.51066625
68	Axon guidance_Homo sapiens_hsa04360	0.51000137
69	Pentose phosphate pathway_Homo sapiens_hsa00030	0.49542999
70	Renin-angiotensin system_Homo sapiens_hsa04614	0.49402171
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.49286883
72	Fatty acid metabolism_Homo sapiens_hsa01212	0.48590639
73	RNA transport_Homo sapiens_hsa03013	0.48166951
74	Cocaine addiction_Homo sapiens_hsa05030	0.47304456
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46994805
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.45847041
77	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45024140
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.44502661
79	Galactose metabolism_Homo sapiens_hsa00052	0.42313789
80	Insulin resistance_Homo sapiens_hsa04931	0.40084743
81	Metabolic pathways_Homo sapiens_hsa01100	0.39181755
82	Shigellosis_Homo sapiens_hsa05131	0.39161266
83	Huntingtons disease_Homo sapiens_hsa05016	0.38619311
84	Alzheimers disease_Homo sapiens_hsa05010	0.37573487
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.37246968
86	Bladder cancer_Homo sapiens_hsa05219	0.35693577
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.34216346
88	AMPK signaling pathway_Homo sapiens_hsa04152	0.32458398
89	MicroRNAs in cancer_Homo sapiens_hsa05206	0.32337069
90	Apoptosis_Homo sapiens_hsa04210	0.28083913
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25762778
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25340453
93	One carbon pool by folate_Homo sapiens_hsa00670	0.24852436
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.24052299
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.22859844
96	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.21794748
97	PPAR signaling pathway_Homo sapiens_hsa03320	0.21293731
98	HTLV-I infection_Homo sapiens_hsa05166	0.20930149
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.20820507
100	Purine metabolism_Homo sapiens_hsa00230	0.20734460

UBQLN4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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