UBR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)6.61087872
2actin-myosin filament sliding (GO:0033275)6.61087872
3actin-mediated cell contraction (GO:0070252)5.70154935
4myofibril assembly (GO:0030239)5.35301708
5regulation of relaxation of muscle (GO:1901077)5.31178232
6sarcomere organization (GO:0045214)4.78033014
7response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.76435938
8cardiac myofibril assembly (GO:0055003)4.76154936
9skeletal muscle contraction (GO:0003009)4.63372675
10striated muscle contraction (GO:0006941)4.62875393
11actin filament-based movement (GO:0030048)4.59342984
12regulation of skeletal muscle contraction (GO:0014819)4.40309676
13synaptic vesicle maturation (GO:0016188)4.38483664
14cardiac muscle contraction (GO:0060048)4.36924847
15regulation of actin filament-based movement (GO:1903115)4.35778684
16cardiac muscle hypertrophy (GO:0003300)4.32373235
17striated muscle hypertrophy (GO:0014897)4.12180663
18glutamate secretion (GO:0014047)4.10230333
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.02795573
20actomyosin structure organization (GO:0031032)4.02287979
21response to inactivity (GO:0014854)3.93487541
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.92073554
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89009734
24regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.88556990
25locomotory exploration behavior (GO:0035641)3.84140943
26skeletal muscle adaptation (GO:0043501)3.62127280
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57818666
28regulation of synaptic vesicle exocytosis (GO:2000300)3.57653865
29positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.57302817
30synaptic vesicle exocytosis (GO:0016079)3.56410598
31muscle hypertrophy (GO:0014896)3.50686834
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.46201625
33muscle contraction (GO:0006936)3.45126249
34creatine metabolic process (GO:0006600)3.38231099
35striated muscle adaptation (GO:0014888)3.35357597
36response to muscle activity (GO:0014850)3.34850441
37dicarboxylic acid biosynthetic process (GO:0043650)3.33382413
38cardiac muscle adaptation (GO:0014887)3.26014294
39cardiac muscle hypertrophy in response to stress (GO:0014898)3.26014294
40muscle hypertrophy in response to stress (GO:0003299)3.26014294
41relaxation of cardiac muscle (GO:0055119)3.21934263
42regulation of synaptic vesicle transport (GO:1902803)3.21499008
43vocalization behavior (GO:0071625)3.20570048
44activation of protein kinase A activity (GO:0034199)3.18230693
45muscle system process (GO:0003012)3.15166510
46neurotransmitter secretion (GO:0007269)3.15090350
47regulation of skeletal muscle cell differentiation (GO:2001014)3.14776521
48plasma membrane repair (GO:0001778)3.14549262
49cell communication by electrical coupling (GO:0010644)3.12413742
50regulation of striated muscle contraction (GO:0006942)3.11959926
51layer formation in cerebral cortex (GO:0021819)3.10621606
52regulation of the force of heart contraction (GO:0002026)3.10151402
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.07138518
54regulation of cardiac muscle cell contraction (GO:0086004)3.05615240
55regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05171162
56adult heart development (GO:0007512)3.04535091
57cellular response to epinephrine stimulus (GO:0071872)3.00639573
58relaxation of muscle (GO:0090075)2.99365095
59regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.98533312
60response to epinephrine (GO:0071871)2.97904633
61regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.97745493
62carnitine shuttle (GO:0006853)2.97388204
63myotube differentiation (GO:0014902)2.96962711
64ventricular cardiac muscle cell action potential (GO:0086005)2.96115415
65sarcoplasmic reticulum calcium ion transport (GO:0070296)2.95984394
66regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94910795
67regulation of synapse structural plasticity (GO:0051823)2.94081846
68protein targeting to Golgi (GO:0000042)2.93823904
69cardiac muscle tissue morphogenesis (GO:0055008)2.92312232
70positive regulation of cation channel activity (GO:2001259)2.92242994
71regulation of glutamate receptor signaling pathway (GO:1900449)2.92187664
72skeletal muscle fiber development (GO:0048741)2.92031720
73cellular potassium ion homeostasis (GO:0030007)2.91451575
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91181800
75glucan catabolic process (GO:0009251)2.90687139
76regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89791116
77neuronal action potential propagation (GO:0019227)2.89259575
78cardiac muscle cell development (GO:0055013)2.88916842
79cell communication involved in cardiac conduction (GO:0086065)2.88540686
80myotube cell development (GO:0014904)2.87657704
81sodium ion export (GO:0071436)2.87051359
82proline transport (GO:0015824)2.86462152
83muscle tissue morphogenesis (GO:0060415)2.85845409
84cerebellar Purkinje cell differentiation (GO:0021702)2.83824379
85fatty acid transmembrane transport (GO:1902001)2.79969402
86gamma-aminobutyric acid transport (GO:0015812)2.79590196
87carnitine transmembrane transport (GO:1902603)2.79482182
88regulation of clathrin-mediated endocytosis (GO:2000369)2.78622091
89negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77390164
90negative regulation of potassium ion transmembrane transport (GO:1901380)2.76952799
91nucleus localization (GO:0051647)2.76859303
92establishment of protein localization to Golgi (GO:0072600)2.74598174
93vesicle transport along microtubule (GO:0047496)2.74249983
94muscle fiber development (GO:0048747)2.73927797
95regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.73812296
96macroautophagy (GO:0016236)2.73018251
97striated muscle atrophy (GO:0014891)2.72255985
98regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72146861
99cellular polysaccharide catabolic process (GO:0044247)2.70585558
100regulation of neuronal synaptic plasticity (GO:0048168)2.70378217
101cardiac cell development (GO:0055006)2.69756521
102exploration behavior (GO:0035640)2.68870354
103interkinetic nuclear migration (GO:0022027)2.68619719
104skeletal muscle tissue development (GO:0007519)2.64910980
105regulation of sarcomere organization (GO:0060297)2.62634342
106cardiac muscle cell action potential (GO:0086001)2.61155062
107carnitine transport (GO:0015879)2.59674335
108amino-acid betaine transport (GO:0015838)2.59674335
109glutamate metabolic process (GO:0006536)2.59421742
110lysine catabolic process (GO:0006554)2.58561362
111lysine metabolic process (GO:0006553)2.58561362
112retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58488150
113regulation of cAMP-dependent protein kinase activity (GO:2000479)2.57413525
114regulation of ARF protein signal transduction (GO:0032012)2.57212423
115positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.57003861
116potassium ion import (GO:0010107)2.56307247
117regulation of calcium ion transmembrane transport (GO:1903169)2.55925466
118regulation of calcium ion transmembrane transporter activity (GO:1901019)2.55925466
119muscle cell cellular homeostasis (GO:0046716)2.55132591
120muscle adaptation (GO:0043500)2.54547804
121ionotropic glutamate receptor signaling pathway (GO:0035235)2.54307441
122regulation of dendritic spine morphogenesis (GO:0061001)2.52575572
123dendrite morphogenesis (GO:0048813)2.51782357
124myoblast fusion (GO:0007520)2.49792665
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.48834188
126organelle transport along microtubule (GO:0072384)2.48269877
127regulation of muscle adaptation (GO:0043502)2.47372199
128regulation of membrane repolarization (GO:0060306)2.47336771
129muscle atrophy (GO:0014889)2.45729998
130membrane depolarization during action potential (GO:0086010)2.44925339
131establishment of nucleus localization (GO:0040023)2.44374986
1322-oxoglutarate metabolic process (GO:0006103)2.43813734
133regulation of cell communication by electrical coupling (GO:0010649)2.43365833
134cerebellar Purkinje cell layer development (GO:0021680)2.41828420
135neuromuscular process controlling balance (GO:0050885)2.41660897
136cardiac muscle cell action potential involved in contraction (GO:0086002)2.40542793
137protein localization to synapse (GO:0035418)2.39926882
138regulation of cardiac muscle contraction (GO:0055117)2.38857778
139neurotransmitter transport (GO:0006836)2.38850561
140neurotransmitter-gated ion channel clustering (GO:0072578)2.37562900
141innervation (GO:0060384)2.37228949
142regulation of sodium ion transmembrane transporter activity (GO:2000649)2.36665844
143detection of calcium ion (GO:0005513)2.36368320
144membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.35790523
145cellular sodium ion homeostasis (GO:0006883)2.35715169
146positive regulation of synapse maturation (GO:0090129)2.34503640
147alanine transport (GO:0032328)2.34255535
148aspartate family amino acid catabolic process (GO:0009068)2.33866678
149dendritic spine morphogenesis (GO:0060997)2.33464404
150dicarboxylic acid catabolic process (GO:0043649)2.33015606
151long-term memory (GO:0007616)2.31116503
152glutamate receptor signaling pathway (GO:0007215)2.30961930
153regulation of excitatory postsynaptic membrane potential (GO:0060079)2.30390239
154regulation of neurotransmitter levels (GO:0001505)2.29715574
155positive regulation of muscle hypertrophy (GO:0014742)2.29443662
156positive regulation of cardiac muscle hypertrophy (GO:0010613)2.29443662
157regulation of synaptic plasticity (GO:0048167)2.28877518
158neuromuscular junction development (GO:0007528)2.27159203
159glycogen catabolic process (GO:0005980)2.26340311
160neuron-neuron synaptic transmission (GO:0007270)2.25601471
161negative regulation of sodium ion transport (GO:0010766)2.25090652
162regulation of postsynaptic membrane potential (GO:0060078)2.24969557
163alpha-linolenic acid metabolic process (GO:0036109)2.24739456
164synaptic transmission, glutamatergic (GO:0035249)2.24172512
165nerve growth factor signaling pathway (GO:0038180)2.24148537
166regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.23745979
167positive regulation of fatty acid beta-oxidation (GO:0032000)2.23279440
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.22448989
169regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.21969560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19834983
2GBX2_23144817_ChIP-Seq_PC3_Human2.60891295
3DROSHA_22980978_ChIP-Seq_HELA_Human2.25439907
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19343219
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07340865
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06511818
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.06112525
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04548990
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04103214
10RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92069290
11ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91783818
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87252354
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86777889
14RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82871657
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82871657
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82535459
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79366849
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76567499
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74829663
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72803544
21REST_21632747_ChIP-Seq_MESCs_Mouse1.68081815
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67888271
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65946590
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62958738
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62833277
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.59786269
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59645046
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57590553
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.57551266
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57154222
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53240623
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.52816451
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52494856
34AR_21572438_ChIP-Seq_LNCaP_Human1.52294701
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50203775
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49902428
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47827572
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.47664931
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44866349
40SOX2_21211035_ChIP-Seq_LN229_Gbm1.44270239
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.41814729
42GATA1_22025678_ChIP-Seq_K562_Human1.41395167
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41248102
44FUS_26573619_Chip-Seq_HEK293_Human1.40257259
45* TBX20_22328084_ChIP-Seq_HEART_Mouse1.40153430
46* TBX20_22080862_ChIP-Seq_HEART_Mouse1.40153430
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.40028071
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.39634640
49IGF1R_20145208_ChIP-Seq_DFB_Human1.39537155
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39336648
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38589558
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.38503808
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.37299726
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.36799668
55TP53_16413492_ChIP-PET_HCT116_Human1.34444065
56* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34352222
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33832621
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.33611659
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.33574209
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32999293
61ZNF274_21170338_ChIP-Seq_K562_Hela1.32523542
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.31551176
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31147366
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.30946088
65AHR_22903824_ChIP-Seq_MCF-7_Human1.30528650
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30516987
67AR_19668381_ChIP-Seq_PC3_Human1.30258437
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.30140186
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29753907
70TAF15_26573619_Chip-Seq_HEK293_Human1.28766794
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.27426590
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.27363366
73* STAT3_23295773_ChIP-Seq_U87_Human1.26966626
74* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25735550
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.25557919
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25312690
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22681557
78ER_23166858_ChIP-Seq_MCF-7_Human1.21126398
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21059272
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20870429
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20498129
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.20084545
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20041990
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19923340
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19040544
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18972221
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18789514
88RXR_22108803_ChIP-Seq_LS180_Human1.18352203
89* E2F1_18555785_Chip-Seq_ESCs_Mouse1.18338186
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17213282
91CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15346263
92PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15004078
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14902259
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14537256
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.14339870
96* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13268994
97AR_25329375_ChIP-Seq_VCAP_Human1.12618398
98* SMAD3_21741376_ChIP-Seq_EPCs_Human1.11842823
99BCAT_22108803_ChIP-Seq_LS180_Human1.11587257
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10711807
101* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10411766
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10377378
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09315093
104TCF4_23295773_ChIP-Seq_U87_Human1.08181695
105KDM2B_26808549_Chip-Seq_K562_Human1.08171169
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07847809
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07807341
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07369541
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.07265769
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.06794623
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06775606
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06260187
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05914119
114* P53_22387025_ChIP-Seq_ESCs_Mouse1.05727944
115SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05392007
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05257293
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04060100
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02514089
119CJUN_26792858_Chip-Seq_BT549_Human1.02076106
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01626992
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.01163399
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.01083076
123* P300_19829295_ChIP-Seq_ESCs_Human1.00723826
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00073750
125NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00073750
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.99917752
127* CMYC_18555785_Chip-Seq_ESCs_Mouse0.99020564
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98551656
129SOX9_26525672_Chip-Seq_HEART_Mouse0.98329302
130* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97772393
131OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97678630
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96013921
133* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95575016
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.95285051
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94870629
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94165106
137ZNF263_19887448_ChIP-Seq_K562_Human0.91215187
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.90322239
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89663473
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87252378
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86352901
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85593045
143TP53_18474530_ChIP-ChIP_U2OS_Human0.85143503
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85007990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.82563852
2MP0004270_analgesia3.32713729
3MP0002837_dystrophic_cardiac_calcinosis2.89463692
4MP0003635_abnormal_synaptic_transmissio2.84381731
5MP0000751_myopathy2.70469017
6MP0009780_abnormal_chondrocyte_physiolo2.53900436
7MP0004130_abnormal_muscle_cell2.44069072
8MP0004145_abnormal_muscle_electrophysio2.43692937
9MP0002139_abnormal_hepatobiliary_system2.38055948
10MP0002063_abnormal_learning/memory/cond2.20965893
11MP0003880_abnormal_central_pattern2.19822452
12MP0002332_abnormal_exercise_endurance2.19792922
13MP0009046_muscle_twitch2.16651960
14MP0005085_abnormal_gallbladder_physiolo2.15960776
15MP0009745_abnormal_behavioral_response2.10817896
16MP0003646_muscle_fatigue2.10344132
17MP0002064_seizures2.07950336
18MP0005360_urolithiasis2.05935397
19MP0002909_abnormal_adrenal_gland2.00458868
20MP0005365_abnormal_bile_salt1.99074937
21MP0002822_catalepsy1.92708231
22MP0000569_abnormal_digit_pigmentation1.92167218
23MP0003950_abnormal_plasma_membrane1.88777160
24MP0005451_abnormal_body_composition1.83787352
25MP0004215_abnormal_myocardial_fiber1.79320177
26MP0000749_muscle_degeneration1.76339786
27MP0004036_abnormal_muscle_relaxation1.74331395
28MP0000747_muscle_weakness1.73607624
29MP0002572_abnormal_emotion/affect_behav1.72141798
30MP0002734_abnormal_mechanical_nocicepti1.68298690
31MP0001661_extended_life_span1.66192533
32MP0000750_abnormal_muscle_regeneration1.63094721
33MP0001486_abnormal_startle_reflex1.61357580
34MP0000733_abnormal_muscle_development1.61258325
35MP0008961_abnormal_basal_metabolism1.60270662
36MP0003252_abnormal_bile_duct1.57812469
37MP0002272_abnormal_nervous_system1.56944404
38MP0010234_abnormal_vibrissa_follicle1.56483797
39MP0004087_abnormal_muscle_fiber1.55726051
40MP0004084_abnormal_cardiac_muscle1.52979600
41MP0003329_amyloid_beta_deposits1.51478116
42MP0002269_muscular_atrophy1.48999230
43MP0004233_abnormal_muscle_weight1.47465454
44MP0001968_abnormal_touch/_nociception1.46248282
45MP0005620_abnormal_muscle_contractility1.43845844
46MP0010329_abnormal_lipoprotein_level1.39708465
47MP0002127_abnormal_cardiovascular_syste1.39613616
48MP0000013_abnormal_adipose_tissue1.38236645
49MP0004510_myositis1.36732575
50MP0008875_abnormal_xenobiotic_pharmacok1.34074693
51MP0004811_abnormal_neuron_physiology1.32478843
52MP0004924_abnormal_behavior1.31843283
53MP0005386_behavior/neurological_phenoty1.31843283
54MP0003633_abnormal_nervous_system1.30295903
55MP0001440_abnormal_grooming_behavior1.30075828
56MP0005330_cardiomyopathy1.27687189
57MP0004484_altered_response_of1.27587141
58MP0002067_abnormal_sensory_capabilities1.26619210
59MP0001501_abnormal_sleep_pattern1.26301453
60MP0005385_cardiovascular_system_phenoty1.26071886
61MP0001544_abnormal_cardiovascular_syste1.26071886
62MP0008569_lethality_at_weaning1.24689156
63MP0004858_abnormal_nervous_system1.22258745
64MP0004185_abnormal_adipocyte_glucose1.19540785
65MP0004085_abnormal_heartbeat1.19237016
66MP0000759_abnormal_skeletal_muscle1.18681780
67MP0004043_abnormal_pH_regulation1.18542821
68MP0005666_abnormal_adipose_tissue1.17475278
69MP0002106_abnormal_muscle_physiology1.15386358
70MP0005187_abnormal_penis_morphology1.14173309
71MP0003221_abnormal_cardiomyocyte_apopto1.12678278
72MP0005646_abnormal_pituitary_gland1.12574391
73MP0002735_abnormal_chemical_nociception1.09301771
74MP0002972_abnormal_cardiac_muscle1.09191604
75MP0004885_abnormal_endolymph1.09070784
76MP0002733_abnormal_thermal_nociception1.07200093
77MP0003690_abnormal_glial_cell1.06402378
78MP0005423_abnormal_somatic_nervous1.04786730
79MP0003705_abnormal_hypodermis_morpholog1.03769137
80MP0005535_abnormal_body_temperature1.03501956
81MP0003195_calcinosis1.02274671
82MP0005369_muscle_phenotype1.00837292
83MP0005375_adipose_tissue_phenotype1.00784015
84MP0008874_decreased_physiological_sensi1.00668197
85MP0002118_abnormal_lipid_homeostasis1.00607473
86MP0002066_abnormal_motor_capabilities/c0.99615837
87MP0000003_abnormal_adipose_tissue0.99564964
88MP0003631_nervous_system_phenotype0.98662824
89MP0002557_abnormal_social/conspecific_i0.97785094
90MP0003045_fibrosis0.97533854
91MP0010352_gastrointestinal_tract_polyps0.96470418
92MP0002009_preneoplasia0.96378257
93MP0001299_abnormal_eye_distance/0.96134363
94MP0003828_pulmonary_edema0.96063673
95MP0002078_abnormal_glucose_homeostasis0.95579724
96MP0003137_abnormal_impulse_conducting0.95245094
97MP0000955_abnormal_spinal_cord0.94620775
98MP0001970_abnormal_pain_threshold0.94320440
99MP0004134_abnormal_chest_morphology0.94135249
100MP0000778_abnormal_nervous_system0.93588950
101MP0005332_abnormal_amino_acid0.90624010
102MP0010368_abnormal_lymphatic_system0.89529496
103MP0002184_abnormal_innervation0.86090312
104MP0006138_congestive_heart_failure0.86002476
105MP0005409_darkened_coat_color0.85367014
106MP0002971_abnormal_brown_adipose0.83851026
107MP0003879_abnormal_hair_cell0.83554042
108MP0002882_abnormal_neuron_morphology0.83099597
109MP0005266_abnormal_metabolism0.83099436
110MP0010630_abnormal_cardiac_muscle0.82784794
111MP0008775_abnormal_heart_ventricle0.82666409
112MP0003283_abnormal_digestive_organ0.81790109
113MP0002736_abnormal_nociception_after0.81788982
114MP0000604_amyloidosis0.81401434
115MP0002108_abnormal_muscle_morphology0.81204294
116MP0000266_abnormal_heart_morphology0.80987493
117MP0005670_abnormal_white_adipose0.80008208
118MP0002229_neurodegeneration0.78184443
119MP0003868_abnormal_feces_composition0.77451489
120MP0003656_abnormal_erythrocyte_physiolo0.77203628
121MP0008438_abnormal_cutaneous_collagen0.75765068
122MP0005275_abnormal_skin_tensile0.75161891
123MP0000462_abnormal_digestive_system0.71439455
124MP0008057_abnormal_DNA_replication0.71215808
125MP0004272_abnormal_basement_membrane0.67618427
126MP0002896_abnormal_bone_mineralization0.65078852
127MP0001177_atelectasis0.65004120
128MP0002128_abnormal_blood_circulation0.63909479
129MP0010678_abnormal_skin_adnexa0.62878568
130MP0003091_abnormal_cell_migration0.58067850
131MP0009115_abnormal_fat_cell0.55568946
132MP0005248_abnormal_Harderian_gland0.54697153
133MP0010386_abnormal_urinary_bladder0.52617530
134MP0003890_abnormal_embryonic-extraembry0.52381254
135MP0002168_other_aberrant_phenotype0.51416026
136MP0003385_abnormal_body_wall0.49833852
137MP0001879_abnormal_lymphatic_vessel0.48765948

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the left ventricular outflow tract (HP:0011103)4.28400458
2Subaortic stenosis (HP:0001682)4.28400458
3Exercise-induced myalgia (HP:0003738)4.15691199
4Focal motor seizures (HP:0011153)4.12847716
5Focal seizures (HP:0007359)3.81714791
6Centrally nucleated skeletal muscle fibers (HP:0003687)3.45919145
7Rimmed vacuoles (HP:0003805)3.45853430
8Round ear (HP:0100830)3.43981592
9Myopathic facies (HP:0002058)3.43606702
10Neck muscle weakness (HP:0000467)3.43174275
11Myokymia (HP:0002411)3.37728789
12Hyporeflexia of lower limbs (HP:0002600)3.27244304
13Dysmetric saccades (HP:0000641)3.21111524
14Exercise-induced muscle cramps (HP:0003710)3.16991823
15Visual hallucinations (HP:0002367)3.14758314
16Sudden death (HP:0001699)3.14094551
17Rhabdomyolysis (HP:0003201)3.12829038
18Ventricular tachycardia (HP:0004756)3.11621077
19Action tremor (HP:0002345)3.04662885
20Difficulty running (HP:0009046)3.01200115
21Hyperventilation (HP:0002883)2.95327746
22Muscle hypertrophy of the lower extremities (HP:0008968)2.92683189
23Asymmetric septal hypertrophy (HP:0001670)2.90489216
24Ulnar deviation of the wrist (HP:0003049)2.87980356
25Abnormal social behavior (HP:0012433)2.87566632
26Impaired social interactions (HP:0000735)2.87566632
27Calf muscle hypertrophy (HP:0008981)2.86417802
28Epileptic encephalopathy (HP:0200134)2.83214149
29Distal lower limb muscle weakness (HP:0009053)2.76444407
30Progressive cerebellar ataxia (HP:0002073)2.73473579
31Postural instability (HP:0002172)2.72883747
32Poor eye contact (HP:0000817)2.72671754
33Generalized tonic-clonic seizures (HP:0002069)2.69101660
34Impaired vibration sensation in the lower limbs (HP:0002166)2.69002272
35Termporal pattern (HP:0011008)2.67872130
36Insidious onset (HP:0003587)2.67872130
37Myoglobinuria (HP:0002913)2.63502620
38Urinary bladder sphincter dysfunction (HP:0002839)2.59153127
39Absence seizures (HP:0002121)2.57854599
40Heart block (HP:0012722)2.55257056
41Ketoacidosis (HP:0001993)2.54410458
42Genetic anticipation (HP:0003743)2.54309643
43Dysdiadochokinesis (HP:0002075)2.54051142
44Areflexia of lower limbs (HP:0002522)2.52344171
45Mildly elevated creatine phosphokinase (HP:0008180)2.51931149
46Dilated cardiomyopathy (HP:0001644)2.51095212
47Broad-based gait (HP:0002136)2.49619312
48Bundle branch block (HP:0011710)2.48488071
49Papillary thyroid carcinoma (HP:0002895)2.47688082
50Abnormality of the calf musculature (HP:0001430)2.45917702
51Lipoatrophy (HP:0100578)2.45116452
52Distal lower limb amyotrophy (HP:0008944)2.43842591
53Fetal akinesia sequence (HP:0001989)2.42338151
54Ketosis (HP:0001946)2.42007419
55Muscle fiber splitting (HP:0003555)2.38344917
56Abnormal atrioventricular conduction (HP:0005150)2.37904080
57Atonic seizures (HP:0010819)2.36787894
58Calcaneovalgus deformity (HP:0001848)2.36226957
59Muscle fiber inclusion bodies (HP:0100299)2.33728696
60Dialeptic seizures (HP:0011146)2.29168473
61Excessive salivation (HP:0003781)2.27677634
62Drooling (HP:0002307)2.27677634
63Type 1 muscle fiber predominance (HP:0003803)2.26617186
64Status epilepticus (HP:0002133)2.26547039
65Syncope (HP:0001279)2.25717020
66Depression (HP:0000716)2.25502244
67Absent phalangeal crease (HP:0006109)2.25450162
68EMG: myopathic abnormalities (HP:0003458)2.25092925
69Epileptiform EEG discharges (HP:0011182)2.24971636
70Increased variability in muscle fiber diameter (HP:0003557)2.24840698
71Myotonia (HP:0002486)2.24661277
72EEG with generalized epileptiform discharges (HP:0011198)2.23727277
73Urinary urgency (HP:0000012)2.23678868
74Hypsarrhythmia (HP:0002521)2.22268750
75Scapular winging (HP:0003691)2.21933764
76Macroorchidism (HP:0000053)2.21755569
77Deep venous thrombosis (HP:0002625)2.21556376
78Dysmetria (HP:0001310)2.21150119
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.21100205
80Abnormality of the lower motor neuron (HP:0002366)2.19653232
81Febrile seizures (HP:0002373)2.18228395
82Gaze-evoked nystagmus (HP:0000640)2.15644519
83Proximal amyotrophy (HP:0007126)2.14022381
84Pheochromocytoma (HP:0002666)2.12166459
85Generalized muscle weakness (HP:0003324)2.08761639
86Deformed tarsal bones (HP:0008119)2.06618672
87Malignant hyperthermia (HP:0002047)2.06581051
88Hip contracture (HP:0003273)2.06050704
89Hypoglycemic coma (HP:0001325)2.05305950
90Prolonged QT interval (HP:0001657)2.05190045
91Ventricular fibrillation (HP:0001663)2.04337530
92Abnormal finger flexion creases (HP:0006143)2.04118713
93Hypoalphalipoproteinemia (HP:0003233)2.03818896
94Hyperglycemia (HP:0003074)2.02236420
95Overgrowth (HP:0001548)2.02186838
96Muscular dystrophy (HP:0003560)2.01970688
97Slender build (HP:0001533)2.01340473
98Supranuclear gaze palsy (HP:0000605)2.00348479
99Abnormality of the ischium (HP:0003174)2.00029324
100Hyperinsulinemic hypoglycemia (HP:0000825)1.99806829
101Impaired vibratory sensation (HP:0002495)1.99762442
102Muscle stiffness (HP:0003552)1.98903888
103Abnormality of the foot musculature (HP:0001436)1.98623879
104Scanning speech (HP:0002168)1.96848229
105Resting tremor (HP:0002322)1.95650270
106Intention tremor (HP:0002080)1.94586433
107Xanthomatosis (HP:0000991)1.93825521
108Intrahepatic cholestasis (HP:0001406)1.92858697
109Supraventricular tachycardia (HP:0004755)1.92621891
110Abnormality of the Achilles tendon (HP:0005109)1.92579978
111Torticollis (HP:0000473)1.92230931
112Abnormality of skeletal muscle fiber size (HP:0012084)1.91766579
113Anxiety (HP:0000739)1.91645916
114Truncal ataxia (HP:0002078)1.91463663
115Spinal rigidity (HP:0003306)1.90323228
116Supraventricular arrhythmia (HP:0005115)1.89507083
117Limited hip movement (HP:0008800)1.89457940
118Atrioventricular block (HP:0001678)1.88663131
119Gowers sign (HP:0003391)1.87460303
120Foot dorsiflexor weakness (HP:0009027)1.85954305
121Lower limb amyotrophy (HP:0007210)1.85911737
122Atrial fibrillation (HP:0005110)1.84974893
123Cerebral inclusion bodies (HP:0100314)1.84484799
124Impaired smooth pursuit (HP:0007772)1.84479414
125Frequent falls (HP:0002359)1.83264803
126Increased connective tissue (HP:0009025)1.82702062
127Right ventricular cardiomyopathy (HP:0011663)1.82502258
128Central scotoma (HP:0000603)1.82162270
129Ankle clonus (HP:0011448)1.81082909
130Epidermoid cyst (HP:0200040)1.80732488
131Long clavicles (HP:0000890)1.79975792
132Achilles tendon contracture (HP:0001771)1.79532781
133EMG: neuropathic changes (HP:0003445)1.79323249
134Distal arthrogryposis (HP:0005684)1.79294286
135Nemaline bodies (HP:0003798)1.79251658
136Gout (HP:0001997)1.78453702
137Abnormality of the corticospinal tract (HP:0002492)1.78173877
138Primary atrial arrhythmia (HP:0001692)1.77356410
139Hemiplegia (HP:0002301)1.76201378
140Insulin-resistant diabetes mellitus (HP:0000831)1.75844454
141Hypoplastic ischia (HP:0003175)1.74962626
142Hyperkalemia (HP:0002153)1.74942184
143Focal dystonia (HP:0004373)1.74138300
144Hyperlipoproteinemia (HP:0010980)1.73547413
145Absent speech (HP:0001344)1.73259025
146Ventricular arrhythmia (HP:0004308)1.72817920
147Metatarsus adductus (HP:0001840)1.69035475
148Difficulty climbing stairs (HP:0003551)1.63443723
149Steppage gait (HP:0003376)1.61650366
150Bulbar palsy (HP:0001283)1.57104225
151Abnormality of the shoulder girdle musculature (HP:0001435)1.55728529
152Abnormality of the hip-girdle musculature (HP:0001445)1.54541134
153Abnormality of the musculature of the pelvis (HP:0001469)1.54541134
154Ulnar deviation of finger (HP:0009465)1.53592173
155Fatigable weakness (HP:0003473)1.50613406
156Abnormality of the neuromuscular junction (HP:0003398)1.50613406
157Abnormal EKG (HP:0003115)1.50421232
158Limb-girdle muscle weakness (HP:0003325)1.49325193
159Limb-girdle muscle atrophy (HP:0003797)1.49063947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.40250536
2MAP3K43.14927195
3MAP3K93.09322866
4EPHA42.87306643
5MAP2K42.63114379
6PIK3CG2.17371812
7PAK62.15247935
8KSR22.02653815
9PHKG21.96913518
10PHKG11.96913518
11MAP2K71.88388726
12DAPK21.85837517
13MINK11.75720251
14TRPM71.70134226
15INSRR1.68650474
16OBSCN1.67504352
17MARK11.65841676
18MAP3K21.62779285
19CAMK1G1.60920533
20CAMKK11.59581809
21CASK1.56453531
22TTN1.48420173
23KSR11.48328185
24DMPK1.48095642
25FGFR31.46486517
26NTRK11.46399754
27PRKD31.42857308
28PNCK1.40234687
29RET1.38633394
30MAP3K71.36210071
31STK381.36193615
32TRIB31.34006857
33PAK31.31611262
34EEF2K1.27165907
35RIPK41.24220200
36SGK31.22768474
37CDK51.20460685
38RIPK11.18922465
39ERBB31.18099040
40PKN21.16925562
41NEK91.16593176
42PDK41.11306179
43PDK31.11306179
44LATS21.08403539
45CAMK1D1.07435856
46NTRK21.07246718
47SGK21.06604005
48LMTK21.06433142
49NEK11.04532795
50FGFR21.04072049
51FRK1.03787473
52CAMKK21.00526928
53BRD40.99254291
54SGK4940.97593548
55SGK2230.97593548
56SIK10.97578173
57PINK10.94227705
58WNK10.94058603
59FER0.93992053
60STK110.93829873
61MUSK0.93485760
62PRKCH0.92320918
63PDK10.90293336
64TAOK10.85166425
65UHMK10.84380826
66PDPK10.82212905
67CDK120.82119810
68CAMK10.82022916
69CCNB10.80391215
70TYRO30.80319183
71PDGFRA0.80186614
72MAPK120.79046047
73SGK10.77445444
74MAP3K10.76014929
75LATS10.76014322
76PDK20.74350246
77CAMK2A0.74260248
78BCKDK0.73715495
79PRKCG0.72927965
80ROCK10.72160077
81ALK0.69626207
82PRKAA10.68730361
83SCYL20.68551543
84MAP3K60.67671292
85WNK40.66115640
86EPHA30.65785503
87PTK2B0.63017388
88CAMK2B0.62500759
89NLK0.61531726
90CAMK40.59870400
91PLK20.59806481
92CAMK2G0.59767547
93RPS6KA30.59742878
94OXSR10.58746524
95MAP2K30.58453955
96PIK3CA0.58278454
97MAP3K130.58223972
98FES0.57311502
99MAP2K10.56834340
100MTOR0.56544837
101STK390.55658593
102PRKG10.55452806
103MAPK70.55351602
104DAPK10.55076461
105PTK60.53322547
106CDC42BPA0.53245850
107JAK10.52857770
108PDGFRB0.51735870
109ICK0.51135225
110RPS6KB10.51054996
111MARK20.50930147
112PRKAA20.50577338
113CAMK2D0.50227348
114STK38L0.49860604
115SIK20.49725302
116CDK190.49293877
117AKT20.48489270
118GRK50.48042244
119MYLK0.47454194
120RAF10.46276408
121AKT30.46218447
122CDK180.46155445
123MAP3K50.45888613
124PRKD10.45501633
125CDK140.45368383
126MAPK100.45294405
127PTK20.45198543
128CSNK1G20.45000295
129TNIK0.44417221
130MAPK130.44044881
131NEK60.42691684
132STK240.40687865
133PRKACB0.36258933
134MAPKAPK30.36074856
135PRKCE0.32028537
136YES10.31494134
137FGFR10.31009149
138MAPK40.30758646

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.04439391
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62050306
3Arginine biosynthesis_Homo sapiens_hsa002201.90983787
4Synaptic vesicle cycle_Homo sapiens_hsa047211.81481439
5Long-term potentiation_Homo sapiens_hsa047201.81281879
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78145194
7Circadian entrainment_Homo sapiens_hsa047131.74358179
8Insulin secretion_Homo sapiens_hsa049111.66415885
9GABAergic synapse_Homo sapiens_hsa047271.63506111
10Nicotine addiction_Homo sapiens_hsa050331.62883224
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60124930
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59774028
13Olfactory transduction_Homo sapiens_hsa047401.53111205
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52855869
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52131464
16Amphetamine addiction_Homo sapiens_hsa050311.51869512
17Type II diabetes mellitus_Homo sapiens_hsa049301.50117652
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46442090
19Glutamatergic synapse_Homo sapiens_hsa047241.45593826
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45248431
21Butanoate metabolism_Homo sapiens_hsa006501.45206083
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.42097390
23Salivary secretion_Homo sapiens_hsa049701.41238232
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41058030
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41057940
26Gastric acid secretion_Homo sapiens_hsa049711.39689393
27Renin secretion_Homo sapiens_hsa049241.35119143
28Dopaminergic synapse_Homo sapiens_hsa047281.34145504
29Propanoate metabolism_Homo sapiens_hsa006401.32072538
30Oxytocin signaling pathway_Homo sapiens_hsa049211.29015221
31Morphine addiction_Homo sapiens_hsa050321.28501881
32Bile secretion_Homo sapiens_hsa049761.26130319
33Cholinergic synapse_Homo sapiens_hsa047251.23027645
34Fatty acid degradation_Homo sapiens_hsa000711.18212086
35Endometrial cancer_Homo sapiens_hsa052131.15408008
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15323820
37Adherens junction_Homo sapiens_hsa045201.12601360
38Dilated cardiomyopathy_Homo sapiens_hsa054141.12330398
39Glucagon signaling pathway_Homo sapiens_hsa049221.11887895
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10266470
41Focal adhesion_Homo sapiens_hsa045101.09771088
42GnRH signaling pathway_Homo sapiens_hsa049121.09716567
43Long-term depression_Homo sapiens_hsa047301.07592126
44Calcium signaling pathway_Homo sapiens_hsa040201.04956141
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03240742
46Tight junction_Homo sapiens_hsa045301.02769143
47Fatty acid metabolism_Homo sapiens_hsa012121.00568476
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96339209
49Dorso-ventral axis formation_Homo sapiens_hsa043200.94898567
50Glioma_Homo sapiens_hsa052140.92796760
51Gap junction_Homo sapiens_hsa045400.92728984
52PPAR signaling pathway_Homo sapiens_hsa033200.90277812
53FoxO signaling pathway_Homo sapiens_hsa040680.89522452
54Renal cell carcinoma_Homo sapiens_hsa052110.88790063
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88754075
56Insulin resistance_Homo sapiens_hsa049310.88128986
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88007052
58Tryptophan metabolism_Homo sapiens_hsa003800.87765947
59cAMP signaling pathway_Homo sapiens_hsa040240.87443490
60Insulin signaling pathway_Homo sapiens_hsa049100.86283191
61Estrogen signaling pathway_Homo sapiens_hsa049150.86266943
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85902743
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85553355
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85409107
65mTOR signaling pathway_Homo sapiens_hsa041500.83942123
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82589319
67Taste transduction_Homo sapiens_hsa047420.81819921
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80676377
69Cocaine addiction_Homo sapiens_hsa050300.80192062
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78206355
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78016459
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.75935103
73Starch and sucrose metabolism_Homo sapiens_hsa005000.75520344
74Fatty acid biosynthesis_Homo sapiens_hsa000610.74551601
75Pyruvate metabolism_Homo sapiens_hsa006200.74542654
76ECM-receptor interaction_Homo sapiens_hsa045120.74027036
77ErbB signaling pathway_Homo sapiens_hsa040120.73114797
78Serotonergic synapse_Homo sapiens_hsa047260.72456938
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71384784
80Prolactin signaling pathway_Homo sapiens_hsa049170.69954223
81Cardiac muscle contraction_Homo sapiens_hsa042600.69281255
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68968263
83Carbon metabolism_Homo sapiens_hsa012000.68286841
84Thyroid hormone synthesis_Homo sapiens_hsa049180.68028604
85Melanogenesis_Homo sapiens_hsa049160.67728974
86Pancreatic secretion_Homo sapiens_hsa049720.67341625
87Platelet activation_Homo sapiens_hsa046110.66176637
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.65054208
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64854926
90AMPK signaling pathway_Homo sapiens_hsa041520.64787959
91Proteoglycans in cancer_Homo sapiens_hsa052050.64280458
92Non-small cell lung cancer_Homo sapiens_hsa052230.64014254
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63649037
94Circadian rhythm_Homo sapiens_hsa047100.63516867
95Ovarian steroidogenesis_Homo sapiens_hsa049130.62965624
96Lysine degradation_Homo sapiens_hsa003100.62517254
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60566333
98Amoebiasis_Homo sapiens_hsa051460.58554484
99beta-Alanine metabolism_Homo sapiens_hsa004100.54450127
100Axon guidance_Homo sapiens_hsa043600.52389559
101Arginine and proline metabolism_Homo sapiens_hsa003300.51922840
102Choline metabolism in cancer_Homo sapiens_hsa052310.48874163
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48209068
104VEGF signaling pathway_Homo sapiens_hsa043700.47938658
105Chronic myeloid leukemia_Homo sapiens_hsa052200.45684653
106Prion diseases_Homo sapiens_hsa050200.45595462
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.45377066
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.45156793
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45149877
110Glycerolipid metabolism_Homo sapiens_hsa005610.44686270
111Biosynthesis of amino acids_Homo sapiens_hsa012300.43511977
112Complement and coagulation cascades_Homo sapiens_hsa046100.43173767
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43005566
114Prostate cancer_Homo sapiens_hsa052150.42838380
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.42166003
116Colorectal cancer_Homo sapiens_hsa052100.41989059
117MAPK signaling pathway_Homo sapiens_hsa040100.41119373
118ABC transporters_Homo sapiens_hsa020100.41087649
119Inositol phosphate metabolism_Homo sapiens_hsa005620.39871386

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