UBR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1macroautophagy (GO:0016236)4.72952833
2regulation of histone H3-K27 methylation (GO:0061085)4.63680846
3cytoplasmic mRNA processing body assembly (GO:0033962)4.41637987
4positive regulation of histone deacetylation (GO:0031065)4.34099605
5Golgi transport vesicle coating (GO:0048200)4.20575383
6COPI coating of Golgi vesicle (GO:0048205)4.20575383
7pre-miRNA processing (GO:0031054)4.02639248
8nuclear pore complex assembly (GO:0051292)3.91317686
9establishment of protein localization to Golgi (GO:0072600)3.83350444
10protein targeting to Golgi (GO:0000042)3.75967523
11activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.70757517
12retrograde transport, vesicle recycling within Golgi (GO:0000301)3.64960213
13peptidyl-lysine dimethylation (GO:0018027)3.57014703
14focal adhesion assembly (GO:0048041)3.52335257
15cell-substrate adherens junction assembly (GO:0007045)3.52335257
16NLS-bearing protein import into nucleus (GO:0006607)3.52167627
17regulation of NFAT protein import into nucleus (GO:0051532)3.52022586
18positive regulation of nuclease activity (GO:0032075)3.49403971
19L-alpha-amino acid transmembrane transport (GO:1902475)3.48121323
20embryonic process involved in female pregnancy (GO:0060136)3.46777735
21negative regulation of erythrocyte differentiation (GO:0045647)3.43979464
22stress granule assembly (GO:0034063)3.40898621
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.38268556
24positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.36325393
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.35298586
26regulation of protein polyubiquitination (GO:1902914)3.34813315
27insulin-like growth factor receptor signaling pathway (GO:0048009)3.32927907
28histone H3-K9 demethylation (GO:0033169)3.27336170
29nuclear pore organization (GO:0006999)3.27030155
30regulation of ARF protein signal transduction (GO:0032012)3.23205177
31mitotic chromosome condensation (GO:0007076)3.18897534
32regulation of nuclease activity (GO:0032069)3.18784372
33mannose metabolic process (GO:0006013)3.11098558
34endoplasmic reticulum unfolded protein response (GO:0030968)3.04384445
35negative regulation of DNA repair (GO:0045738)3.02463430
36plasma membrane repair (GO:0001778)2.97836950
37histone H3-K36 demethylation (GO:0070544)2.96710878
38negative regulation of cell size (GO:0045792)2.96206034
39positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.95717200
40positive regulation of p38MAPK cascade (GO:1900745)2.94145876
41cellular response to unfolded protein (GO:0034620)2.94081007
42DNA unwinding involved in DNA replication (GO:0006268)2.92796194
43COPII vesicle coating (GO:0048208)2.91230895
44negative regulation of myotube differentiation (GO:0010832)2.88086776
45vesicle coating (GO:0006901)2.87948094
46definitive hemopoiesis (GO:0060216)2.87206353
47regulation of translational fidelity (GO:0006450)2.86449811
48ER-nucleus signaling pathway (GO:0006984)2.84852762
49growth hormone receptor signaling pathway (GO:0060396)2.84794239
50glucocorticoid receptor signaling pathway (GO:0042921)2.83695133
51negative regulation of histone methylation (GO:0031061)2.78155248
52protein export from nucleus (GO:0006611)2.77991480
53regulation of p38MAPK cascade (GO:1900744)2.77317319
54histone H3-K4 methylation (GO:0051568)2.77308693
55negative regulation of fatty acid transport (GO:2000192)2.75782130
56dosage compensation (GO:0007549)2.75387520
57gene silencing by RNA (GO:0031047)2.71130603
58positive regulation of protein deacetylation (GO:0090312)2.70455432
59pore complex assembly (GO:0046931)2.69963058
60response to epidermal growth factor (GO:0070849)2.69523250
61embryonic camera-type eye morphogenesis (GO:0048596)2.68514463
62gene silencing (GO:0016458)2.66247510
63regulation of histone methylation (GO:0031060)2.65453404
64cellular response to topologically incorrect protein (GO:0035967)2.65409378
65positive regulation of protein import into nucleus, translocation (GO:0033160)2.64625344
66histone lysine demethylation (GO:0070076)2.64282526
67regulation of histone H3-K4 methylation (GO:0051569)2.63353393
68heterochromatin organization (GO:0070828)2.62834356
69monoubiquitinated protein deubiquitination (GO:0035520)2.62669753
70histone H3-K4 trimethylation (GO:0080182)2.61937696
71DNA duplex unwinding (GO:0032508)2.58471387
72positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.56944469
73synaptonemal complex assembly (GO:0007130)2.56528806
74negative regulation of translation, ncRNA-mediated (GO:0040033)2.56145265
75regulation of translation, ncRNA-mediated (GO:0045974)2.56145265
76negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56145265
77regulation of mRNA catabolic process (GO:0061013)2.50851181
78intra-Golgi vesicle-mediated transport (GO:0006891)2.50778073
79histone lysine methylation (GO:0034968)2.50469408
80histone H4-K16 acetylation (GO:0043984)2.48525520
81regulation of RNA export from nucleus (GO:0046831)2.47815462
82RNA stabilization (GO:0043489)2.47365614
83mRNA stabilization (GO:0048255)2.47365614
84regulation of polysaccharide biosynthetic process (GO:0032885)2.46885268
85cellular response to growth hormone stimulus (GO:0071378)2.46620783
86histone demethylation (GO:0016577)2.46449615
87peptidyl-threonine phosphorylation (GO:0018107)2.45237795
88Golgi organization (GO:0007030)2.44180307
89embryonic eye morphogenesis (GO:0048048)2.44093291
90regulation of ARF GTPase activity (GO:0032312)2.43986316
91negative regulation of histone modification (GO:0031057)2.42745558
92regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.42577029
93corticosteroid receptor signaling pathway (GO:0031958)2.42386432
94peptidyl-threonine modification (GO:0018210)2.42286691
95activation of Rac GTPase activity (GO:0032863)2.42220430
96cellular response to epidermal growth factor stimulus (GO:0071364)2.40973097
97positive thymic T cell selection (GO:0045059)2.40742084
98positive regulation of gamma-delta T cell activation (GO:0046645)2.40395283
99chromatin silencing (GO:0006342)2.39838862
100neural tube development (GO:0021915)2.39579297
101DNA geometric change (GO:0032392)2.39531064
102positive regulation of glycogen biosynthetic process (GO:0045725)2.39442317
103endoplasmic reticulum organization (GO:0007029)2.37841300
104epithelial cell fate commitment (GO:0072148)2.37727086
105regulation of cholesterol homeostasis (GO:2000188)2.37338160
106regulation of glucose import in response to insulin stimulus (GO:2001273)2.37305113
107membrane disassembly (GO:0030397)2.37246215
108nuclear envelope disassembly (GO:0051081)2.37246215
109regulation of early endosome to late endosome transport (GO:2000641)2.36460314
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.35375471
111regulation of gamma-delta T cell differentiation (GO:0045586)2.35051533
112response to endoplasmic reticulum stress (GO:0034976)2.34453274
113phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.34256043
114adherens junction assembly (GO:0034333)2.34175236
115lipid translocation (GO:0034204)2.33897208
116phospholipid translocation (GO:0045332)2.33897208
117mitotic sister chromatid cohesion (GO:0007064)2.33532911
118mitotic nuclear envelope disassembly (GO:0007077)2.32292431
119spliceosomal tri-snRNP complex assembly (GO:0000244)2.32177117
120regulation of histone deacetylation (GO:0031063)2.32019659
121negative regulation of organelle assembly (GO:1902116)2.31911573
122regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.31844585
123positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.31844585
124positive regulation of hormone biosynthetic process (GO:0046886)2.30964821
125interkinetic nuclear migration (GO:0022027)2.30297487
126apoptotic cell clearance (GO:0043277)2.29703077
127protein localization to endosome (GO:0036010)2.28754636
128histone H4-K8 acetylation (GO:0043982)2.28399315
129histone H4-K5 acetylation (GO:0043981)2.28399315
130cell-substrate junction assembly (GO:0007044)2.28205130
131negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.28115569
132hemidesmosome assembly (GO:0031581)2.28091763
133DNA synthesis involved in DNA repair (GO:0000731)2.28038352
134synaptonemal complex organization (GO:0070193)2.27775153
135embryonic retina morphogenesis in camera-type eye (GO:0060059)2.27483042
136protein dealkylation (GO:0008214)2.26935273
137protein demethylation (GO:0006482)2.26935273
138peptidyl-lysine trimethylation (GO:0018023)2.26338209
139sodium ion export (GO:0071436)2.26287293
140sister chromatid segregation (GO:0000819)2.26223434
141regulation of nucleobase-containing compound transport (GO:0032239)2.25434930
142regulation of gamma-delta T cell activation (GO:0046643)2.24766774
143coronary vasculature morphogenesis (GO:0060977)2.24560995
144response to laminar fluid shear stress (GO:0034616)2.24388528
145cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.24349090
146positive regulation of glycolytic process (GO:0045821)2.23719846
147regulation of interleukin-12 biosynthetic process (GO:0045075)2.23588490
148skin morphogenesis (GO:0043589)2.22407791
149hypotonic response (GO:0006971)2.21956245
150heart morphogenesis (GO:0003007)2.21127384
151regulation of histone H3-K9 methylation (GO:0051570)2.20867829
152establishment of spindle localization (GO:0051293)2.20174180
153cortical actin cytoskeleton organization (GO:0030866)2.19730214
154establishment of spindle orientation (GO:0051294)2.18489178
155trophectodermal cell differentiation (GO:0001829)2.18190367
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.17126951
157negative regulation of striated muscle cell differentiation (GO:0051154)2.15799324
158regulation of DNA damage checkpoint (GO:2000001)2.15222125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.77371554
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.59994848
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.18061263
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70342832
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69784077
6GATA1_22025678_ChIP-Seq_K562_Human2.55829481
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49777059
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45876641
9TCF7_22412390_ChIP-Seq_EML_Mouse2.29196442
10* MYC_22102868_ChIP-Seq_BL_Human2.26904467
11* KDM2B_26808549_Chip-Seq_DND41_Human2.21852035
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.21615572
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19304888
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18120579
15DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.00589080
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95941155
17KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93448103
18* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88113287
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88001594
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75302598
21KDM2B_26808549_Chip-Seq_K562_Human1.74321286
22ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59104441
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.55158558
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54906629
25KDM2B_26808549_Chip-Seq_JURKAT_Human1.54351002
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53145997
27DROSHA_22980978_ChIP-Seq_HELA_Human1.51165576
28SCL_19346495_ChIP-Seq_HPC-7_Human1.49250330
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48648638
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47891282
31* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47421060
32* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46173962
33GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46083733
34SPI1_23127762_ChIP-Seq_K562_Human1.45611244
35GATA1_19941826_ChIP-Seq_K562_Human1.45279089
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44191707
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42763073
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38173854
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38116105
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.37024713
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.36443134
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35831908
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35105844
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.33488452
45* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32369252
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32170128
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31913000
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.31891553
49NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.31651078
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31417340
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31108087
52* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30681727
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28992608
54FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.28829429
55VDR_21846776_ChIP-Seq_THP-1_Human1.28225501
56UTX_26944678_Chip-Seq_JUKART_Human1.27711749
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.27348641
58TBX20_22080862_ChIP-Seq_HEART_Mouse1.27348641
59* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27185146
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.27060391
61FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26857583
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26426196
63CREB1_26743006_Chip-Seq_LNCaP_Human1.26345812
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.25521415
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23949544
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.23193274
67* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22164699
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22071291
69ZNF263_19887448_ChIP-Seq_K562_Human1.21934805
70AR_21909140_ChIP-Seq_LNCAP_Human1.21627788
71LXR_22292898_ChIP-Seq_THP-1_Human1.21486972
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.20983129
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20368930
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18149558
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16854938
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16854938
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16145149
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.15961377
79NCOR1_26117541_ChIP-Seq_K562_Human1.15601219
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14908272
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14869323
82* ELK3_25401928_ChIP-Seq_HUVEC_Human1.14054116
83VDR_24763502_ChIP-Seq_THP-1_Human1.13684037
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13664934
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13285237
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13283883
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13203119
88* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12998690
89CHD1_26751641_Chip-Seq_LNCaP_Human1.11595478
90* MAF_26560356_Chip-Seq_TH1_Human1.11108795
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.11012435
92CLOCK_20551151_ChIP-Seq_293T_Human1.10925029
93* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09984069
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08247023
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.08056830
96* RACK7_27058665_Chip-Seq_MCF-7_Human1.08042333
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.06599455
98* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05911436
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05400042
100* GATA6_25053715_ChIP-Seq_YYC3_Human1.04977149
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04834340
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04811616
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04444990
104AHR_22903824_ChIP-Seq_MCF-7_Human1.03914959
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03632613
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03594296
107* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03526070
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03428174
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03420025
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03062198
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02890991
112GATA1_19941827_ChIP-Seq_MEL_Mouse1.00788624
113* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00730042
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00500703
115TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99148941
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99068740
117* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98692727
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98152731
119E2F1_21310950_ChIP-Seq_MCF-7_Human0.97044587
120TP53_22127205_ChIP-Seq_IMR90_Human0.96921852
121* MYB_26560356_Chip-Seq_TH1_Human0.96642224
122* GATA2_21666600_ChIP-Seq_HMVEC_Human0.94715081
123RUNX_20019798_ChIP-Seq_JUKART_Human0.93939193
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92671612
125GATA2_19941826_ChIP-Seq_K562_Human0.92217225
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91477827
127PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91342184
128* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91301776
129* ATF3_27146783_Chip-Seq_COLON_Human0.91123109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.93061372
2MP0002877_abnormal_melanocyte_morpholog3.56549298
3MP0003300_gastrointestinal_ulcer3.47797009
4MP0005076_abnormal_cell_differentiation3.32989100
5MP0009780_abnormal_chondrocyte_physiolo3.17066057
6MP0008961_abnormal_basal_metabolism3.16354422
7MP0008057_abnormal_DNA_replication3.11785419
8MP0003283_abnormal_digestive_organ3.06906948
9MP0005451_abnormal_body_composition3.05355435
10MP0003705_abnormal_hypodermis_morpholog2.95332260
11MP0003045_fibrosis2.73061148
12MP0010352_gastrointestinal_tract_polyps2.62912389
13MP0002909_abnormal_adrenal_gland2.58691547
14MP0008438_abnormal_cutaneous_collagen2.48431280
15MP0002009_preneoplasia2.48352866
16MP0005409_darkened_coat_color2.47283711
17MP0005670_abnormal_white_adipose2.22043540
18MP0003172_abnormal_lysosome_physiology2.08410786
19MP0003183_abnormal_peptide_metabolism2.05426509
20MP0010307_abnormal_tumor_latency2.05347592
21MP0003566_abnormal_cell_adhesion1.97427907
22MP0000003_abnormal_adipose_tissue1.96428896
23MP0004264_abnormal_extraembryonic_tissu1.88915124
24MP0002396_abnormal_hematopoietic_system1.87727562
25MP0009278_abnormal_bone_marrow1.83629377
26MP0004272_abnormal_basement_membrane1.81509487
27MP0000013_abnormal_adipose_tissue1.77236209
28MP0008877_abnormal_DNA_methylation1.74571086
29MP0010234_abnormal_vibrissa_follicle1.73306673
30MP0003111_abnormal_nucleus_morphology1.70079313
31MP0005375_adipose_tissue_phenotype1.67939152
32MP0003950_abnormal_plasma_membrane1.63066672
33MP0002693_abnormal_pancreas_physiology1.61267611
34MP0003656_abnormal_erythrocyte_physiolo1.60068651
35MP0003787_abnormal_imprinting1.59979553
36MP0001661_extended_life_span1.56704933
37MP0005666_abnormal_adipose_tissue1.56446445
38MP0003453_abnormal_keratinocyte_physiol1.55547551
39MP0003252_abnormal_bile_duct1.51236415
40MP0004233_abnormal_muscle_weight1.49849024
41MP0003091_abnormal_cell_migration1.48742347
42MP0001944_abnormal_pancreas_morphology1.46966486
43MP0004185_abnormal_adipocyte_glucose1.46757834
44MP0005410_abnormal_fertilization1.45574752
45MP0004130_abnormal_muscle_cell1.44862700
46MP0003303_peritoneal_inflammation1.39687039
47MP0004510_myositis1.39444709
48MP0002928_abnormal_bile_duct1.37876488
49MP0003763_abnormal_thymus_physiology1.33845749
50MP0004858_abnormal_nervous_system1.25242160
51MP0000350_abnormal_cell_proliferation1.24629819
52MP0005275_abnormal_skin_tensile1.23669042
53MP0002078_abnormal_glucose_homeostasis1.23481718
54MP0005623_abnormal_meninges_morphology1.22617440
55MP0002269_muscular_atrophy1.21255291
56MP0002837_dystrophic_cardiac_calcinosis1.20081453
57MP0000733_abnormal_muscle_development1.19682593
58MP0009672_abnormal_birth_weight1.18834746
59MP0000371_diluted_coat_color1.18212787
60MP0004197_abnormal_fetal_growth/weight/1.17905792
61MP0002168_other_aberrant_phenotype1.17372947
62MP0010630_abnormal_cardiac_muscle1.16590762
63MP0001849_ear_inflammation1.14655401
64MP0003077_abnormal_cell_cycle1.12892821
65MP0001348_abnormal_lacrimal_gland1.11937976
66MP0002166_altered_tumor_susceptibility1.11858498
67MP0002234_abnormal_pharynx_morphology1.10013550
68MP0002896_abnormal_bone_mineralization1.09084452
69MP0001299_abnormal_eye_distance/1.08387205
70MP0004087_abnormal_muscle_fiber1.08040590
71MP0009840_abnormal_foam_cell1.07857230
72MP0009703_decreased_birth_body1.07458847
73MP0002089_abnormal_postnatal_growth/wei1.06313764
74MP0004084_abnormal_cardiac_muscle1.02459320
75MP0002086_abnormal_extraembryonic_tissu1.01273487
76MP0002060_abnormal_skin_morphology1.00552712
77MP0006138_congestive_heart_failure0.98678701
78MP0003115_abnormal_respiratory_system0.97092812
79MP0004808_abnormal_hematopoietic_stem0.96750480
80MP0002084_abnormal_developmental_patter0.95924148
81MP0008260_abnormal_autophagy0.94771968
82MP0003828_pulmonary_edema0.94693069
83MP0002088_abnormal_embryonic_growth/wei0.93056830
84MP0003984_embryonic_growth_retardation0.92825147
85MP0010094_abnormal_chromosome_stability0.91884167
86MP0001873_stomach_inflammation0.90077244
87MP0003121_genomic_imprinting0.89830477
88MP0004947_skin_inflammation0.89085799
89MP0003941_abnormal_skin_development0.88228062
90MP0009115_abnormal_fat_cell0.87999439
91MP0005023_abnormal_wound_healing0.87249550
92MP0000767_abnormal_smooth_muscle0.84597110
93MP0005380_embryogenesis_phenotype0.84166040
94MP0001672_abnormal_embryogenesis/_devel0.84166040
95MP0003866_abnormal_defecation0.84117714
96MP0002925_abnormal_cardiovascular_devel0.83838824
97MP0000537_abnormal_urethra_morphology0.83710586
98MP0004043_abnormal_pH_regulation0.83198665
99MP0000703_abnormal_thymus_morphology0.83174887
100MP0005621_abnormal_cell_physiology0.83015418
101MP0001730_embryonic_growth_arrest0.81875599
102MP0001958_emphysema0.80627509
103MP0000266_abnormal_heart_morphology0.79831327
104MP0003385_abnormal_body_wall0.79789887
105MP0002998_abnormal_bone_remodeling0.79647904
106MP0003890_abnormal_embryonic-extraembry0.79387039
107MP0002085_abnormal_embryonic_tissue0.78557798
108MP0002006_tumorigenesis0.78543195
109MP0005058_abnormal_lysosome_morphology0.78293724
110MP0000747_muscle_weakness0.78052169
111MP0008007_abnormal_cellular_replicative0.77981895
112MP0003122_maternal_imprinting0.77907848
113MP0000751_myopathy0.77387792
114MP0003221_abnormal_cardiomyocyte_apopto0.76402816
115MP0004957_abnormal_blastocyst_morpholog0.75636832
116MP0000609_abnormal_liver_physiology0.73656954
117MP0004036_abnormal_muscle_relaxation0.73454493
118MP0002970_abnormal_white_adipose0.73040346
119MP0005187_abnormal_penis_morphology0.72710216
120MP0000428_abnormal_craniofacial_morphol0.72260698
121MP0002108_abnormal_muscle_morphology0.71937615
122MP0008770_decreased_survivor_rate0.71419189
123MP0001915_intracranial_hemorrhage0.70446669
124MP0003698_abnormal_male_reproductive0.70345067
125MP0001784_abnormal_fluid_regulation0.67538400
126MP0005334_abnormal_fat_pad0.67510946
127MP0000678_abnormal_parathyroid_gland0.66944253
128MP0005448_abnormal_energy_balance0.65349124
129MP0000759_abnormal_skeletal_muscle0.64207983
130MP0001929_abnormal_gametogenesis0.63167752
131MP0005384_cellular_phenotype0.62407258
132MP0002080_prenatal_lethality0.59967300
133MP0002971_abnormal_brown_adipose0.59649226
134MP0005257_abnormal_intraocular_pressure0.59499925
135MP0001697_abnormal_embryo_size0.58865065
136MP0005397_hematopoietic_system_phenotyp0.57850134
137MP0001545_abnormal_hematopoietic_system0.57850134
138MP0003119_abnormal_digestive_system0.57653845

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)3.80397924
2Abnormality of the fingertips (HP:0001211)3.71509542
3Cerebral aneurysm (HP:0004944)3.50965165
4Heterotopia (HP:0002282)3.01979538
5Hand muscle atrophy (HP:0009130)2.91246267
6Hyperinsulinemic hypoglycemia (HP:0000825)2.84003986
7Ankyloglossia (HP:0010296)2.83263645
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.81513837
9Distal upper limb amyotrophy (HP:0007149)2.79394932
10Upper limb amyotrophy (HP:0009129)2.79394932
11Hyperacusis (HP:0010780)2.75134234
12Urethral obstruction (HP:0000796)2.70088805
13Broad face (HP:0000283)2.64616526
14Abnormality of the lower motor neuron (HP:0002366)2.60908165
15Protrusio acetabuli (HP:0003179)2.60568291
16Aneurysm (HP:0002617)2.55125313
17Disproportionate tall stature (HP:0001519)2.49090922
18Abnormality of oral frenula (HP:0000190)2.42812039
19Flat acetabular roof (HP:0003180)2.42121654
20Dislocated radial head (HP:0003083)2.40976100
21Hyperglycemia (HP:0003074)2.40879104
22Abnormality of the astrocytes (HP:0100707)2.38077573
23Astrocytoma (HP:0009592)2.38077573
24Hyporeflexia of lower limbs (HP:0002600)2.37390949
25Truncal obesity (HP:0001956)2.36513312
26Difficulty running (HP:0009046)2.32926245
27Persistence of primary teeth (HP:0006335)2.32141167
28Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.31912783
29Hypoglycemic seizures (HP:0002173)2.29603936
30Frequent falls (HP:0002359)2.29518317
31Insulin-resistant diabetes mellitus (HP:0000831)2.25110305
32Ependymoma (HP:0002888)2.23103504
33Resting tremor (HP:0002322)2.22874806
34Dysmetric saccades (HP:0000641)2.21727444
35Neoplasm of the heart (HP:0100544)2.19298842
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17377891
37Narrow palate (HP:0000189)2.15870699
38Abnormality of the radial head (HP:0003995)2.14714999
39Relative macrocephaly (HP:0004482)2.11178220
40Elfin facies (HP:0004428)2.10450002
41Abnormality of the distal phalanx of the thumb (HP:0009617)2.10074142
42Abnormality of the pancreatic islet cells (HP:0006476)2.09610767
43Abnormality of endocrine pancreas physiology (HP:0012093)2.09610767
44EMG: neuropathic changes (HP:0003445)2.08265442
45Renovascular hypertension (HP:0100817)2.08173854
46Long toe (HP:0010511)2.06273020
47Obstructive sleep apnea (HP:0002870)2.04453847
48Acute myeloid leukemia (HP:0004808)2.01663453
49Long eyelashes (HP:0000527)2.00695009
50Pancreatic islet-cell hyperplasia (HP:0004510)1.99252505
51Osteolytic defects of the phalanges of the hand (HP:0009771)1.98231155
52Osteolytic defects of the hand bones (HP:0009699)1.98231155
53Overgrowth (HP:0001548)1.97112122
54Bowel incontinence (HP:0002607)1.96769540
55Limited elbow extension (HP:0001377)1.96692150
56Hypoplastic ischia (HP:0003175)1.96062766
57Premature rupture of membranes (HP:0001788)1.95997114
58Bowel diverticulosis (HP:0005222)1.94367428
59Sparse lateral eyebrow (HP:0005338)1.91205705
60Arterial tortuosity (HP:0005116)1.91007929
61Insomnia (HP:0100785)1.90490462
62Increased connective tissue (HP:0009025)1.89712401
63Centrally nucleated skeletal muscle fibers (HP:0003687)1.89075579
64Subacute progressive viral hepatitis (HP:0006572)1.88162777
65Advanced eruption of teeth (HP:0006288)1.87937069
66Spinal cord lesions (HP:0100561)1.87205559
67Syringomyelia (HP:0003396)1.87205559
68Neonatal hypoglycemia (HP:0001998)1.86605552
69Deep philtrum (HP:0002002)1.86343217
70Increased CSF protein (HP:0002922)1.84408055
71Vertebral arch anomaly (HP:0008438)1.82419484
72Abnormality of the ischium (HP:0003174)1.82407064
73Obsessive-compulsive behavior (HP:0000722)1.82195386
74Broad palm (HP:0001169)1.82036316
75Abnormal large intestine physiology (HP:0012700)1.81580882
76Shallow orbits (HP:0000586)1.79606512
77Lower limb amyotrophy (HP:0007210)1.79159292
78Hypoplastic labia majora (HP:0000059)1.78874076
79Spinal muscular atrophy (HP:0007269)1.78596677
80Absent frontal sinuses (HP:0002688)1.78502491
81Bundle branch block (HP:0011710)1.77417658
82Prominent nose (HP:0000448)1.77218533
83Wormian bones (HP:0002645)1.76852264
84Turricephaly (HP:0000262)1.76785964
85Sandal gap (HP:0001852)1.76709034
86Overlapping toe (HP:0001845)1.75702614
87Patellar dislocation (HP:0002999)1.73863843
88Reticulocytosis (HP:0001923)1.73595366
89Nasal polyposis (HP:0100582)1.72862905
90Mitral valve prolapse (HP:0001634)1.72859552
91Abnormality of the calcaneus (HP:0008364)1.72393107
92Global brain atrophy (HP:0002283)1.71864285
93Mildly elevated creatine phosphokinase (HP:0008180)1.71509869
94Colitis (HP:0002583)1.71480931
95Large for gestational age (HP:0001520)1.71138797
96Asymmetry of the thorax (HP:0001555)1.71107860
97Aortic aneurysm (HP:0004942)1.70079596
98Broad thumb (HP:0011304)1.67713214
99Vascular tortuosity (HP:0004948)1.67559330
100Symptomatic seizures (HP:0011145)1.67505444
101Glioma (HP:0009733)1.67267961
102Hypoglycemic coma (HP:0001325)1.67127352
103Difficulty climbing stairs (HP:0003551)1.66031336
104Cubitus valgus (HP:0002967)1.63459656
105Deep venous thrombosis (HP:0002625)1.62455106
106Aortic dissection (HP:0002647)1.62184754
107Mask-like facies (HP:0000298)1.61847571
108Smooth philtrum (HP:0000319)1.61844207
109Enlarged penis (HP:0000040)1.61783370
110Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.61220779
111Proximal amyotrophy (HP:0007126)1.61085146
112Volvulus (HP:0002580)1.60551998
113Papillary thyroid carcinoma (HP:0002895)1.59855153
114Abnormality of the epiphyses of the hand (HP:0005924)1.59846165
115Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59696813
116Short 4th metacarpal (HP:0010044)1.59696813
117Myocardial infarction (HP:0001658)1.59651932
118Impaired smooth pursuit (HP:0007772)1.59590183
119Pseudobulbar signs (HP:0002200)1.59212625
120Abnormality of the labia majora (HP:0012881)1.59043376
121Flat cornea (HP:0007720)1.58311505
122Abnormality of ocular smooth pursuit (HP:0000617)1.58018960
123Distal lower limb amyotrophy (HP:0008944)1.57768550
124Skull defect (HP:0001362)1.57655817
125Abnormality of the humeroradial joint (HP:0100744)1.56580016
126Joint laxity (HP:0001388)1.56443400
127Increased nuchal translucency (HP:0010880)1.56420937
128Decreased motor nerve conduction velocity (HP:0003431)1.56412558
129Anal stenosis (HP:0002025)1.56271453
130Deep palmar crease (HP:0006191)1.56098550
131Long palpebral fissure (HP:0000637)1.55819188
132Striae distensae (HP:0001065)1.55797024
133Hypopigmentation of the fundus (HP:0007894)1.55184206
134Abnormal foot bone ossification (HP:0010675)1.54819648
135Dilatation of the ascending aorta (HP:0005111)1.54785806
136Male infertility (HP:0003251)1.54643972
137Thin ribs (HP:0000883)1.54228233
138Pointed chin (HP:0000307)1.53912070
139Thick eyebrow (HP:0000574)1.53691174
140Hypercortisolism (HP:0001578)1.53553942
141Abnormal ossification of hand bones (HP:0005921)1.53078608
142Cervical subluxation (HP:0003308)1.52970985
143Biconcave vertebral bodies (HP:0004586)1.52934341
144Mitral regurgitation (HP:0001653)1.52366445
145Progressive hearing impairment (HP:0001730)1.52334133
146Severe short stature (HP:0003510)1.51509222
147Hammertoe (HP:0001765)1.50572233
148Onion bulb formation (HP:0003383)1.49054897
149High pitched voice (HP:0001620)1.48975569
150Metaphyseal cupping (HP:0003021)1.48651327
151Cupped ribs (HP:0000887)1.48573635
152Asymmetric septal hypertrophy (HP:0001670)1.48412260
153Renal duplication (HP:0000075)1.48296816
154Autoimmune thrombocytopenia (HP:0001973)1.47752399
155Prominent forehead (HP:0011220)1.47372923
156Bronchomalacia (HP:0002780)1.47324289
157Germ cell neoplasia (HP:0100728)1.46967609
158Ulnar bowing (HP:0003031)1.46625073
159Genetic anticipation (HP:0003743)1.46463579
160Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.46107128
161Abnormality of the thoracic spine (HP:0100711)1.45753658
162Atrophic scars (HP:0001075)1.44850610
163Natal tooth (HP:0000695)1.44810668
164Coarse hair (HP:0002208)1.44588320
165Tapered finger (HP:0001182)1.44257473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.46440708
2TRIB32.96568655
3PRKD32.91829699
4CAMK1G2.56968222
5PRPF4B2.50862069
6TAOK32.50711351
7CAMK1D2.36456870
8ICK2.26819136
9MAP3K102.16528007
10SMG12.13997912
11EEF2K2.13386934
12RIPK12.10914881
13BRD41.99938931
14PKN21.97617281
15PDGFRA1.94176110
16PTK61.92807099
17TTN1.89381415
18AKT31.88479662
19SIK11.84999391
20INSRR1.82923763
21SCYL21.68019059
22ERN11.66885713
23* MTOR1.60062644
24KSR21.58434297
25FGFR41.56456428
26FGFR31.46507968
27IRAK31.46342414
28JAK11.44300910
29LATS11.42460793
30PASK1.38084459
31TRPM71.36063282
32ALK1.32190433
33CDC42BPA1.28254251
34SIK21.22877071
35MAP3K131.20647959
36PRKCH1.19870970
37MAP2K31.18370074
38MAP3K21.18123735
39SGK31.13857497
40WNK11.13041492
41PDGFRB1.09035608
42HIPK21.08499986
43JAK31.08230092
44EPHB11.05875565
45PTK21.05437040
46MELK1.03291859
47RET1.02007461
48FLT31.01390576
49EPHA31.00669542
50MAP3K70.97558777
51MST1R0.96165202
52MAPK110.95928822
53LATS20.91859614
54PNCK0.91111565
55MAP3K60.90850658
56TAOK10.87652857
57PDK40.86817176
58PDK30.86817176
59MARK20.86153903
60RIPK40.85771628
61TYK20.84268807
62MAP3K90.83983377
63MAP3K140.83822607
64NTRK10.83765999
65STK380.83608736
66PRKAA10.82862476
67TYRO30.77045494
68CDK60.75932229
69NEK20.75377898
70JAK20.75375483
71CHUK0.75363578
72CLK10.72149574
73SGK20.71239125
74RAF10.70749698
75DYRK1B0.70573042
76DDR20.69738240
77BMX0.69329615
78NEK90.69096956
79MAP4K10.68155679
80FRK0.68082288
81KSR10.67687516
82MAP3K10.66987560
83CDK90.65902903
84DMPK0.65049706
85RPS6KB20.64033092
86STK30.61243735
87MAP3K40.57546447
88LMTK20.57169913
89PAK20.56697642
90PRKD20.56502802
91MAP3K80.55843277
92DAPK20.53959799
93EPHA20.53334240
94SGK10.52633122
95CAMKK10.52455965
96RPS6KA20.52344572
97CHEK10.51440317
98PDK10.50575515
99STK110.50321376
100MAPK100.49858019
101SGK4940.49627712
102SGK2230.49627712
103PAK60.49244174
104PRKDC0.48340393
105CDK70.46687490
106ATM0.46287629
107HCK0.45452024
108NLK0.45226495
109FGFR10.45044006
110MAPK140.44101644
111NTRK30.43930968
112CDK40.43913041
113EGFR0.43644681
114MARK30.43515914
115RPS6KA30.42979929
116RPS6KB10.42444506
117PRKD10.41635439
118GSK3B0.41630604
119CAMK40.41367931
120CDK10.41204579
121MET0.41042406
122FGFR20.40437998
123ZAP700.39783991
124PDPK10.39294795
125MAPK80.39237290
126TTK0.39106703
127CDK20.39078649
128FER0.38875244
129MAPK10.38821272
130PRKAA20.38279635
131STK40.37987984
132RPS6KC10.37623748
133RPS6KL10.37623748
134AKT10.35635603

Predicted pathways (KEGG)

RankGene SetZ-score
1Type II diabetes mellitus_Homo sapiens_hsa049302.61137057
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.31561438
3Lysine degradation_Homo sapiens_hsa003102.15770020
4Dorso-ventral axis formation_Homo sapiens_hsa043202.00838051
5Carbohydrate digestion and absorption_Homo sapiens_hsa049731.85839290
6mTOR signaling pathway_Homo sapiens_hsa041501.78672597
7Insulin resistance_Homo sapiens_hsa049311.72409677
8Insulin secretion_Homo sapiens_hsa049111.71999662
9Thyroid cancer_Homo sapiens_hsa052161.57415623
10Other glycan degradation_Homo sapiens_hsa005111.56304439
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46600219
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.46099551
13Glucagon signaling pathway_Homo sapiens_hsa049221.39444887
14Nitrogen metabolism_Homo sapiens_hsa009101.39028027
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39009269
16Chronic myeloid leukemia_Homo sapiens_hsa052201.37293554
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36262654
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31504672
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29336822
20Longevity regulating pathway - mammal_Homo sapiens_hsa042111.27786168
21Insulin signaling pathway_Homo sapiens_hsa049101.24231411
22Estrogen signaling pathway_Homo sapiens_hsa049151.20656307
23Colorectal cancer_Homo sapiens_hsa052101.18297223
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.16866476
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15956957
26Prolactin signaling pathway_Homo sapiens_hsa049171.13023770
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.12755131
28AMPK signaling pathway_Homo sapiens_hsa041521.11106952
29ABC transporters_Homo sapiens_hsa020101.09861434
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.09531497
31Hepatitis B_Homo sapiens_hsa051611.09412460
32Adherens junction_Homo sapiens_hsa045201.08549434
33Glioma_Homo sapiens_hsa052141.08116831
34ECM-receptor interaction_Homo sapiens_hsa045121.06872193
35Inositol phosphate metabolism_Homo sapiens_hsa005621.06786883
36Endometrial cancer_Homo sapiens_hsa052131.03151052
37Selenocompound metabolism_Homo sapiens_hsa004501.02414142
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00475266
39Acute myeloid leukemia_Homo sapiens_hsa052210.97523785
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96988788
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95699492
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95559021
43Proteoglycans in cancer_Homo sapiens_hsa052050.95277621
44Prion diseases_Homo sapiens_hsa050200.94615063
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93251720
46Focal adhesion_Homo sapiens_hsa045100.93105299
47Non-small cell lung cancer_Homo sapiens_hsa052230.89792989
48Type I diabetes mellitus_Homo sapiens_hsa049400.88492285
49mRNA surveillance pathway_Homo sapiens_hsa030150.87952933
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87459409
51B cell receptor signaling pathway_Homo sapiens_hsa046620.87358820
52Hepatitis C_Homo sapiens_hsa051600.86311310
53Dilated cardiomyopathy_Homo sapiens_hsa054140.86206648
54Notch signaling pathway_Homo sapiens_hsa043300.86014534
55MicroRNAs in cancer_Homo sapiens_hsa052060.84464525
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84212331
57Small cell lung cancer_Homo sapiens_hsa052220.83897733
58Cell cycle_Homo sapiens_hsa041100.82837213
59Toxoplasmosis_Homo sapiens_hsa051450.81057771
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80010057
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.79368048
62Apoptosis_Homo sapiens_hsa042100.78822949
63Prostate cancer_Homo sapiens_hsa052150.78285601
64Osteoclast differentiation_Homo sapiens_hsa043800.77486744
65Long-term potentiation_Homo sapiens_hsa047200.76964284
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76201429
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.76126435
68Thyroid hormone synthesis_Homo sapiens_hsa049180.75303344
69Amoebiasis_Homo sapiens_hsa051460.74361923
70Fatty acid biosynthesis_Homo sapiens_hsa000610.74213663
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74078380
72Bile secretion_Homo sapiens_hsa049760.74048511
73Pancreatic cancer_Homo sapiens_hsa052120.72845640
74FoxO signaling pathway_Homo sapiens_hsa040680.70004973
75Renal cell carcinoma_Homo sapiens_hsa052110.69364158
76Pathways in cancer_Homo sapiens_hsa052000.68068307
77T cell receptor signaling pathway_Homo sapiens_hsa046600.67284377
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67168728
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67140059
80Renin secretion_Homo sapiens_hsa049240.67062737
81ErbB signaling pathway_Homo sapiens_hsa040120.66983386
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65968499
83VEGF signaling pathway_Homo sapiens_hsa043700.65275728
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65257856
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.64797562
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.64052684
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63908544
88Cocaine addiction_Homo sapiens_hsa050300.63756135
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63386795
90Influenza A_Homo sapiens_hsa051640.63314862
91Melanoma_Homo sapiens_hsa052180.62129479
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61976203
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61831954
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60952248
95Viral myocarditis_Homo sapiens_hsa054160.60655506
96HIF-1 signaling pathway_Homo sapiens_hsa040660.59443401
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59362292
98Gastric acid secretion_Homo sapiens_hsa049710.59282943
99Cholinergic synapse_Homo sapiens_hsa047250.58677907
100cAMP signaling pathway_Homo sapiens_hsa040240.58625403
101MAPK signaling pathway_Homo sapiens_hsa040100.58471449
102Antigen processing and presentation_Homo sapiens_hsa046120.58384433
103Pancreatic secretion_Homo sapiens_hsa049720.58371284
104TNF signaling pathway_Homo sapiens_hsa046680.57572471
105GnRH signaling pathway_Homo sapiens_hsa049120.56284989
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55573922
107Platelet activation_Homo sapiens_hsa046110.54783024
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54283473
109Endocytosis_Homo sapiens_hsa041440.54266205
110HTLV-I infection_Homo sapiens_hsa051660.52673616
111Bladder cancer_Homo sapiens_hsa052190.52589413
112Choline metabolism in cancer_Homo sapiens_hsa052310.52010282
113Amphetamine addiction_Homo sapiens_hsa050310.51575631
114Rap1 signaling pathway_Homo sapiens_hsa040150.51478205
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.50706474
116Chemokine signaling pathway_Homo sapiens_hsa040620.50698125
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50350332
118Fructose and mannose metabolism_Homo sapiens_hsa000510.50234530
119* Viral carcinogenesis_Homo sapiens_hsa052030.50101315
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50065036
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49869897
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.49521990
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48979151
124Measles_Homo sapiens_hsa051620.48824944
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48800399
126Complement and coagulation cascades_Homo sapiens_hsa046100.46844278
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46328229
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45486122
129TGF-beta signaling pathway_Homo sapiens_hsa043500.44183720

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