UBR7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.70976507
2nuclear pore organization (GO:0006999)5.10071821
3DNA replication-dependent nucleosome organization (GO:0034723)5.09262374
4DNA replication-dependent nucleosome assembly (GO:0006335)5.09262374
5DNA replication initiation (GO:0006270)5.02942414
6DNA strand elongation involved in DNA replication (GO:0006271)4.94725927
7nuclear pore complex assembly (GO:0051292)4.88792997
8protein localization to kinetochore (GO:0034501)4.81967400
9DNA strand elongation (GO:0022616)4.67975868
10mitotic nuclear envelope disassembly (GO:0007077)4.57385298
11DNA ligation (GO:0006266)4.55892037
12folic acid-containing compound biosynthetic process (GO:0009396)4.52576266
13DNA topological change (GO:0006265)4.48066723
14telomere maintenance via semi-conservative replication (GO:0032201)4.38178897
15nucleobase biosynthetic process (GO:0046112)4.37322845
16membrane disassembly (GO:0030397)4.29613915
17nuclear envelope disassembly (GO:0051081)4.29613915
18IMP biosynthetic process (GO:0006188)4.21319632
19protein localization to chromosome, centromeric region (GO:0071459)4.17961748
20regulation of histone H3-K9 methylation (GO:0051570)4.07079637
21regulation of gene silencing by miRNA (GO:0060964)4.07051739
22regulation of gene silencing by RNA (GO:0060966)4.07051739
23regulation of posttranscriptional gene silencing (GO:0060147)4.07051739
24mitotic chromosome condensation (GO:0007076)4.03761006
25DNA duplex unwinding (GO:0032508)4.01779938
26DNA geometric change (GO:0032392)4.01731442
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.99853596
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.99853596
29DNA replication checkpoint (GO:0000076)3.96975038
30mitotic metaphase plate congression (GO:0007080)3.92462526
31purine nucleobase biosynthetic process (GO:0009113)3.91004033
32formation of translation preinitiation complex (GO:0001731)3.90514345
33non-recombinational repair (GO:0000726)3.89364033
34double-strand break repair via nonhomologous end joining (GO:0006303)3.89364033
35mitotic recombination (GO:0006312)3.84877198
36telomere maintenance via recombination (GO:0000722)3.83766491
37chromatin remodeling at centromere (GO:0031055)3.79807115
38mitotic sister chromatid segregation (GO:0000070)3.77978286
39regulation of helicase activity (GO:0051095)3.77329230
40sister chromatid segregation (GO:0000819)3.77275961
41deoxyribonucleotide biosynthetic process (GO:0009263)3.77159151
42IMP metabolic process (GO:0046040)3.73094840
43CENP-A containing nucleosome assembly (GO:0034080)3.65850491
44chromosome segregation (GO:0007059)3.63949046
45pre-miRNA processing (GO:0031054)3.62003701
46establishment of viral latency (GO:0019043)3.61972409
47pore complex assembly (GO:0046931)3.61249776
48telomere maintenance via telomere lengthening (GO:0010833)3.60744183
49DNA replication-independent nucleosome assembly (GO:0006336)3.59202078
50DNA replication-independent nucleosome organization (GO:0034724)3.59202078
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.57651918
52mitotic sister chromatid cohesion (GO:0007064)3.56025776
53negative regulation of histone methylation (GO:0031061)3.53373339
54regulation of double-strand break repair via homologous recombination (GO:0010569)3.53282115
55metaphase plate congression (GO:0051310)3.52078443
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50748262
57histone exchange (GO:0043486)3.43869554
58dosage compensation (GO:0007549)3.43582673
59heterochromatin organization (GO:0070828)3.41849463
60chromatin assembly or disassembly (GO:0006333)3.40212170
61attachment of spindle microtubules to kinetochore (GO:0008608)3.40078431
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39467745
63kinetochore organization (GO:0051383)3.38548961
64regulation of DNA endoreduplication (GO:0032875)3.38294984
65regulation of translational fidelity (GO:0006450)3.37846970
66positive regulation of chromosome segregation (GO:0051984)3.36858930
67DNA conformation change (GO:0071103)3.35812416
68translesion synthesis (GO:0019985)3.34560592
69kinetochore assembly (GO:0051382)3.34191628
70regulation of mitotic sister chromatid separation (GO:0010965)3.33920703
71regulation of mitotic sister chromatid segregation (GO:0033047)3.33920703
72regulation of sister chromatid segregation (GO:0033045)3.33920703
73DNA packaging (GO:0006323)3.31497081
74negative regulation of DNA recombination (GO:0045910)3.31487560
75base-excision repair (GO:0006284)3.30877967
76nuclear envelope organization (GO:0006998)3.30019290
77postreplication repair (GO:0006301)3.30007086
78regulation of centrosome cycle (GO:0046605)3.28994280
79regulation of translational termination (GO:0006449)3.28383019
80mitotic cell cycle (GO:0000278)3.27972107
81maturation of SSU-rRNA (GO:0030490)3.27127427
82regulation of spindle organization (GO:0090224)3.25988082
83establishment of chromosome localization (GO:0051303)3.25265994
84regulation of chromosome segregation (GO:0051983)3.24689524
85regulation of sister chromatid cohesion (GO:0007063)3.20747965
86regulation of centriole replication (GO:0046599)3.19479485
87chromatin assembly (GO:0031497)3.19309134
88ribosome assembly (GO:0042255)3.19128802
89mismatch repair (GO:0006298)3.17915347
90negative regulation of chromosome segregation (GO:0051985)3.16871799
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16469686
92chromosome condensation (GO:0030261)3.15544202
93L-serine metabolic process (GO:0006563)3.15390180
94V(D)J recombination (GO:0033151)3.14551326
95cell cycle G1/S phase transition (GO:0044843)3.13614660
96G1/S transition of mitotic cell cycle (GO:0000082)3.13614660
97protein localization to chromosome (GO:0034502)3.12988191
98protein K6-linked ubiquitination (GO:0085020)3.12478421
99negative regulation of mitotic sister chromatid separation (GO:2000816)3.10090339
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10090339
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10090339
102negative regulation of sister chromatid segregation (GO:0033046)3.10090339
103microtubule depolymerization (GO:0007019)3.09419598
104ribosomal small subunit assembly (GO:0000028)3.07431615
105ATP-dependent chromatin remodeling (GO:0043044)3.06745196
106ribosome biogenesis (GO:0042254)3.03840375
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03005821
108spindle assembly checkpoint (GO:0071173)3.02165115
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00483825
110regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00330768
111spliceosomal tri-snRNP complex assembly (GO:0000244)2.98532801
112mitotic spindle assembly checkpoint (GO:0007094)2.97597452
113telomere maintenance (GO:0000723)2.97308805
114spindle checkpoint (GO:0031577)2.97176489
115telomere organization (GO:0032200)2.96890346
116positive regulation of mitotic sister chromatid separation (GO:1901970)2.96290609
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96290609
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96290609
119meiotic chromosome segregation (GO:0045132)2.95029064
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93129361
121regulation of mitotic spindle organization (GO:0060236)2.93033757
122mitotic spindle checkpoint (GO:0071174)2.92679990
123establishment of integrated proviral latency (GO:0075713)2.92644147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.75770470
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95165836
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.93552663
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35508536
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10202453
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93953875
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66297320
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.53556072
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50251393
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41747296
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31749618
12AR_21909140_ChIP-Seq_LNCAP_Human2.30996999
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.20446196
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17130135
15XRN2_22483619_ChIP-Seq_HELA_Human2.10104471
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.09305353
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03373220
18E2F7_22180533_ChIP-Seq_HELA_Human10.3945434
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98848433
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.97245976
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97180555
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97027596
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93805687
24MYC_22102868_ChIP-Seq_BL_Human1.90566519
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90035431
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88886731
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88295442
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86322595
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81344262
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76185355
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76085514
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.74872918
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73203376
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.72297357
35* VDR_23849224_ChIP-Seq_CD4+_Human1.67513863
36FOXP3_21729870_ChIP-Seq_TREG_Human1.58619738
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55887699
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55718805
39CIITA_25753668_ChIP-Seq_RAJI_Human1.55362154
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54919424
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54646866
42TTF2_22483619_ChIP-Seq_HELA_Human1.54346919
43GABP_19822575_ChIP-Seq_HepG2_Human1.48396295
44DCP1A_22483619_ChIP-Seq_HELA_Human1.46647976
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44041720
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43363715
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.43123278
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41917753
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39023605
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39023605
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39023605
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36273507
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35075451
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34139554
55KDM5A_27292631_Chip-Seq_BREAST_Human1.32572971
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31436144
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29671579
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28337158
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25718188
60ELK1_19687146_ChIP-ChIP_HELA_Human1.24601809
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24077098
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23448496
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23323424
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21669343
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20854581
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19828287
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18611257
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18400214
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17355947
70TFEB_21752829_ChIP-Seq_HELA_Human1.16095683
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16041757
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15427069
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13935444
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13662440
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12998753
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12396392
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12131754
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.11507876
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.11361483
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08150330
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.06413752
82ZNF263_19887448_ChIP-Seq_K562_Human1.05086949
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03791572
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03195538
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01326816
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01041235
87* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99650710
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98014333
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97993834
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96990212
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96936107
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96798148
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.96789317
94SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96157073
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94953648
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.94846859
97VDR_21846776_ChIP-Seq_THP-1_Human0.92090490
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91851525
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89118165
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88674655
101SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88333102
102MYC_18940864_ChIP-ChIP_HL60_Human0.88129278
103SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87124516
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86613763
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85818562
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84033269
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.83597150
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82860850
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82276451
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81851740
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78757317
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77569104
113CHD1_26751641_Chip-Seq_LNCaP_Human0.76616694
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.75111917
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.68686277
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.65955362
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65860316
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.64721562
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.61269205
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.60789354
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.59550037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.95510231
2MP0003693_abnormal_embryo_hatching4.64876471
3MP0003111_abnormal_nucleus_morphology4.45037524
4MP0004957_abnormal_blastocyst_morpholog4.25001476
5MP0003077_abnormal_cell_cycle3.93103125
6MP0008057_abnormal_DNA_replication3.71719957
7MP0008058_abnormal_DNA_repair3.18885108
8MP0010352_gastrointestinal_tract_polyps3.15799689
9MP0001730_embryonic_growth_arrest2.67206126
10MP0010307_abnormal_tumor_latency2.60369571
11MP0003123_paternal_imprinting2.60292947
12MP0000350_abnormal_cell_proliferation2.42588745
13MP0008877_abnormal_DNA_methylation2.35570775
14MP0008007_abnormal_cellular_replicative2.35445345
15MP0008932_abnormal_embryonic_tissue2.35062500
16MP0005380_embryogenesis_phenotype2.08778752
17MP0001672_abnormal_embryogenesis/_devel2.08778752
18MP0001697_abnormal_embryo_size2.05854745
19MP0002084_abnormal_developmental_patter1.95354518
20MP0004197_abnormal_fetal_growth/weight/1.93499601
21MP0009697_abnormal_copulation1.90920838
22MP0003984_embryonic_growth_retardation1.89071648
23MP0002085_abnormal_embryonic_tissue1.87553565
24MP0002088_abnormal_embryonic_growth/wei1.86449527
25MP0002080_prenatal_lethality1.82713473
26MP0002086_abnormal_extraembryonic_tissu1.82503759
27MP0003567_abnormal_fetal_cardiomyocyte1.79758812
28MP0003121_genomic_imprinting1.78929384
29MP0002396_abnormal_hematopoietic_system1.75890775
30MP0005076_abnormal_cell_differentiation1.73471101
31MP0003705_abnormal_hypodermis_morpholog1.73140080
32MP0003806_abnormal_nucleotide_metabolis1.70489345
33MP0006054_spinal_hemorrhage1.67981448
34MP0001346_abnormal_lacrimal_gland1.64468929
35MP0003890_abnormal_embryonic-extraembry1.63725270
36MP0004133_heterotaxia1.58244693
37MP0000537_abnormal_urethra_morphology1.55014519
38MP0010030_abnormal_orbit_morphology1.52111069
39MP0000490_abnormal_crypts_of1.48414287
40MP0001293_anophthalmia1.45787924
41MP0003786_premature_aging1.44549737
42MP0000313_abnormal_cell_death1.42306717
43MP0004808_abnormal_hematopoietic_stem1.40062751
44MP0003283_abnormal_digestive_organ1.38401522
45MP0003119_abnormal_digestive_system1.36245082
46MP0002019_abnormal_tumor_incidence1.35202924
47MP0002210_abnormal_sex_determination1.28848633
48MP0004185_abnormal_adipocyte_glucose1.27626549
49MP0001929_abnormal_gametogenesis1.22190588
50MP0001145_abnormal_male_reproductive1.18549151
51MP0001529_abnormal_vocalization1.16241304
52MP0002653_abnormal_ependyma_morphology1.14203200
53MP0010234_abnormal_vibrissa_follicle1.10791307
54MP0006035_abnormal_mitochondrial_morpho1.09927278
55MP0003566_abnormal_cell_adhesion1.09653908
56MP0009672_abnormal_birth_weight1.09464658
57MP0009053_abnormal_anal_canal1.06644755
58MP0003941_abnormal_skin_development1.03173713
59MP0001849_ear_inflammation1.00013335
60MP0009703_decreased_birth_body0.99054583
61MP0000653_abnormal_sex_gland0.98161668
62MP0001915_intracranial_hemorrhage0.97467923
63MP0002009_preneoplasia0.95877651
64MP0000703_abnormal_thymus_morphology0.94335360
65MP0003718_maternal_effect0.92446504
66MP0002938_white_spotting0.90516340
67MP0005397_hematopoietic_system_phenotyp0.89360775
68MP0001545_abnormal_hematopoietic_system0.89360775
69MP0006292_abnormal_olfactory_placode0.87844464
70MP0002925_abnormal_cardiovascular_devel0.86537472
71MP0000372_irregular_coat_pigmentation0.85106684
72MP0002111_abnormal_tail_morphology0.83608251
73MP0004264_abnormal_extraembryonic_tissu0.83452282
74MP0000358_abnormal_cell_content/0.82244042
75MP0005384_cellular_phenotype0.80909801
76MP0005023_abnormal_wound_healing0.80029176
77MP0002092_abnormal_eye_morphology0.79676882
78MP0000428_abnormal_craniofacial_morphol0.79207999
79MP0003937_abnormal_limbs/digits/tail_de0.78869187
80MP0009278_abnormal_bone_marrow0.78531153
81MP0006036_abnormal_mitochondrial_physio0.77662392
82MP0003698_abnormal_male_reproductive0.77123241
83MP0002697_abnormal_eye_size0.76132219
84MP0005501_abnormal_skin_physiology0.75894757
85MP0005621_abnormal_cell_physiology0.75808736
86MP0003221_abnormal_cardiomyocyte_apopto0.74515948
87MP0000516_abnormal_urinary_system0.73615243
88MP0005367_renal/urinary_system_phenotyp0.73615243
89MP0003943_abnormal_hepatobiliary_system0.73480891
90MP0001177_atelectasis0.73193656
91MP0005623_abnormal_meninges_morphology0.72769633
92MP0008789_abnormal_olfactory_epithelium0.72418971
93MP0003115_abnormal_respiratory_system0.72321220
94MP0004233_abnormal_muscle_weight0.71731852
95MP0002095_abnormal_skin_pigmentation0.71395687
96MP0002877_abnormal_melanocyte_morpholog0.71237454
97MP0002127_abnormal_cardiovascular_syste0.71164398
98MP0000858_altered_metastatic_potential0.70453958
99MP0002722_abnormal_immune_system0.69764009
100MP0002398_abnormal_bone_marrow0.69130309
101MP0003861_abnormal_nervous_system0.69033137
102MP0000266_abnormal_heart_morphology0.68356334
103MP0005266_abnormal_metabolism0.68326619
104MP0002233_abnormal_nose_morphology0.67930166
105MP0003755_abnormal_palate_morphology0.67669222
106MP0005410_abnormal_fertilization0.67086073
107MP0004084_abnormal_cardiac_muscle0.67078827
108MP0002075_abnormal_coat/hair_pigmentati0.66958250
109MP0008770_decreased_survivor_rate0.66528498
110MP0004147_increased_porphyrin_level0.66212271
111MP0001286_abnormal_eye_development0.66028888
112MP0005187_abnormal_penis_morphology0.65587143
113MP0003315_abnormal_perineum_morphology0.65461651
114MP0000733_abnormal_muscle_development0.65243985
115MP0005394_taste/olfaction_phenotype0.64852886
116MP0005499_abnormal_olfactory_system0.64852886
117MP0002160_abnormal_reproductive_system0.63506748
118MP0000371_diluted_coat_color0.63235666
119MP0002161_abnormal_fertility/fecundity0.62781226
120MP0005075_abnormal_melanosome_morpholog0.62654972
121MP0001727_abnormal_embryo_implantation0.61695624
122MP0003385_abnormal_body_wall0.61205376
123MP0008260_abnormal_autophagy0.61195785
124MP0000477_abnormal_intestine_morphology0.61049028
125MP0003935_abnormal_craniofacial_develop0.60796139
126MP0001119_abnormal_female_reproductive0.60506141
127MP0000689_abnormal_spleen_morphology0.59997690
128MP0002269_muscular_atrophy0.57070257
129MP0002081_perinatal_lethality0.55810056
130MP0002970_abnormal_white_adipose0.55171666
131MP0000534_abnormal_ureter_morphology0.54887861
132MP0003699_abnormal_female_reproductive0.54728110
133MP0002177_abnormal_outer_ear0.53261984

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.03200618
2Medulloblastoma (HP:0002885)4.43047931
3Birth length less than 3rd percentile (HP:0003561)4.21480486
4Colon cancer (HP:0003003)3.75045255
5Selective tooth agenesis (HP:0001592)3.69288348
6Chromsome breakage (HP:0040012)3.65776685
7Abnormality of the astrocytes (HP:0100707)3.56855200
8Astrocytoma (HP:0009592)3.56855200
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49384803
10Agnosia (HP:0010524)3.47033246
11Rhabdomyosarcoma (HP:0002859)3.37266674
12Abnormality of chromosome stability (HP:0003220)3.33751592
13Reticulocytopenia (HP:0001896)3.19802839
14Breast hypoplasia (HP:0003187)3.13001108
15Nephroblastoma (Wilms tumor) (HP:0002667)3.10684448
16Abnormality of the labia minora (HP:0012880)3.08625541
17Cortical dysplasia (HP:0002539)3.02350644
18Glioma (HP:0009733)3.02253624
19Abnormal gallbladder physiology (HP:0012438)2.96732847
20Cholecystitis (HP:0001082)2.96732847
21Neoplasm of the oral cavity (HP:0100649)2.94672414
22Basal cell carcinoma (HP:0002671)2.92531334
23Embryonal renal neoplasm (HP:0011794)2.89841359
24Increased nuchal translucency (HP:0010880)2.88370067
25Meckel diverticulum (HP:0002245)2.85077656
26Absent radius (HP:0003974)2.84255658
27Patellar aplasia (HP:0006443)2.83681765
28Degeneration of anterior horn cells (HP:0002398)2.83001971
29Abnormality of the anterior horn cell (HP:0006802)2.83001971
30Neoplasm of striated muscle (HP:0009728)2.80037443
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.77230370
32Proximal placement of thumb (HP:0009623)2.76500206
33Deviation of the thumb (HP:0009603)2.73779269
34Short 4th metacarpal (HP:0010044)2.73251568
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.73251568
36Aplasia involving forearm bones (HP:0009822)2.73158398
37Absent forearm bone (HP:0003953)2.73158398
38Missing ribs (HP:0000921)2.73040732
39Abnormality of the ileum (HP:0001549)2.71884256
40Oral leukoplakia (HP:0002745)2.70940033
41Absent thumb (HP:0009777)2.66165318
42Biliary tract neoplasm (HP:0100574)2.65608171
43Impulsivity (HP:0100710)2.65231018
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63175376
45Abnormality of the preputium (HP:0100587)2.61809583
46Supernumerary spleens (HP:0009799)2.60974744
47Small intestinal stenosis (HP:0012848)2.57096355
48Duodenal stenosis (HP:0100867)2.57096355
49Aplasia/Hypoplasia of the patella (HP:0006498)2.56848528
50Clubbing of toes (HP:0100760)2.54304831
51Volvulus (HP:0002580)2.49818118
5211 pairs of ribs (HP:0000878)2.48684745
53Abnormality of cells of the erythroid lineage (HP:0012130)2.45867326
54Abnormality of the carotid arteries (HP:0005344)2.43566045
55Cafe-au-lait spot (HP:0000957)2.43379146
56Myelodysplasia (HP:0002863)2.41959868
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.41555652
58Progressive external ophthalmoplegia (HP:0000590)2.37531235
59High pitched voice (HP:0001620)2.36582978
60Abnormality of glycolysis (HP:0004366)2.35643695
61Neoplasm of the pancreas (HP:0002894)2.35616116
62Spinal muscular atrophy (HP:0007269)2.35441606
63Microglossia (HP:0000171)2.34331090
64Amaurosis fugax (HP:0100576)2.32872340
65Multiple enchondromatosis (HP:0005701)2.32557145
66Abnormal number of incisors (HP:0011064)2.30334869
67Abnormal number of erythroid precursors (HP:0012131)2.25826553
68Atresia of the external auditory canal (HP:0000413)2.24918653
69Triphalangeal thumb (HP:0001199)2.24085907
70Abnormality of abdominal situs (HP:0011620)2.23101135
71Abdominal situs inversus (HP:0003363)2.23101135
72Angiofibromas (HP:0010615)2.22795687
73Adenoma sebaceum (HP:0009720)2.22795687
74Choanal atresia (HP:0000453)2.21907354
75Embryonal neoplasm (HP:0002898)2.21265053
76Abnormality of the duodenum (HP:0002246)2.21213919
77Arteriovenous malformation (HP:0100026)2.21132852
78Postnatal microcephaly (HP:0005484)2.19667416
79Ectopic kidney (HP:0000086)2.18367387
80Sloping forehead (HP:0000340)2.17469703
81Abnormality of the lower motor neuron (HP:0002366)2.16520562
82Tracheoesophageal fistula (HP:0002575)2.16285452
83Aplasia/hypoplasia of the humerus (HP:0006507)2.14556132
84Deep philtrum (HP:0002002)2.14168624
85Abnormal lung lobation (HP:0002101)2.13515130
86Gastrointestinal carcinoma (HP:0002672)2.10962999
87Malignant gastrointestinal tract tumors (HP:0006749)2.10962999
88Prominent nose (HP:0000448)2.10699296
89Aplastic anemia (HP:0001915)2.09291238
90Carpal bone hypoplasia (HP:0001498)2.09212638
91Microvesicular hepatic steatosis (HP:0001414)2.09061807
92Renal duplication (HP:0000075)2.08830534
93Ovarian neoplasm (HP:0100615)2.08474723
94Short humerus (HP:0005792)2.06621263
95Facial hemangioma (HP:0000329)2.02646337
96Increased serum pyruvate (HP:0003542)2.02410738
97Abnormal umbilical cord blood vessels (HP:0011403)2.02175004
98Single umbilical artery (HP:0001195)2.02175004
99Abnormality of the fetal cardiovascular system (HP:0010948)2.02175004
100Abnormality of the calcaneus (HP:0008364)2.02075788
101Abnormality of chromosome segregation (HP:0002916)2.00023180
102Squamous cell carcinoma (HP:0002860)1.99685605
103Intestinal polyp (HP:0005266)1.99217008
104Hypoplastic pelvis (HP:0008839)1.97334017
105Abnormality of the 4th metacarpal (HP:0010012)1.97026887
106Bone marrow hypocellularity (HP:0005528)1.96829484
107Spastic diplegia (HP:0001264)1.96477127
108Neoplasm of the colon (HP:0100273)1.94335514
109Skull defect (HP:0001362)1.91354167
110Hyperacusis (HP:0010780)1.90608939
111Intestinal polyposis (HP:0200008)1.90191771
112Overlapping toe (HP:0001845)1.89648988
113Neoplasm of the rectum (HP:0100743)1.86210386
114Horseshoe kidney (HP:0000085)1.86118884
115Abnormality of cochlea (HP:0000375)1.85622652
116Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85265293
117Nervous tissue neoplasm (HP:0030060)1.85197528
118Neuroectodermal neoplasm (HP:0030061)1.85197528
119Neuroepithelial neoplasm (HP:0030063)1.85197528
120Esophageal atresia (HP:0002032)1.84240143
121Abnormality of pyrimidine metabolism (HP:0004353)1.84233723
122Insomnia (HP:0100785)1.83939569
123Cellular immunodeficiency (HP:0005374)1.83243452
124Progressive muscle weakness (HP:0003323)1.81857842
125Slender long bone (HP:0003100)1.81572753
126Premature graying of hair (HP:0002216)1.81559374
127Rough bone trabeculation (HP:0100670)1.81419740
128Abnormality of the salivary glands (HP:0010286)1.80458620
129Abnormality of the umbilical cord (HP:0010881)1.80317277
130Trismus (HP:0000211)1.80234079
131Duplicated collecting system (HP:0000081)1.79884644
132Short thumb (HP:0009778)1.79553075
133Septate vagina (HP:0001153)1.79478628
134Abnormality of the diencephalon (HP:0010662)1.79295112
135Broad distal phalanx of finger (HP:0009836)1.79089051
136Freckling (HP:0001480)1.78957311
137Overriding aorta (HP:0002623)1.78641370
138Duplication of thumb phalanx (HP:0009942)1.78219988
139Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.76583504
140Neuroblastoma (HP:0003006)1.76583504
141Primitive neuroectodermal tumor (HP:0030065)1.76583504
142Neuroblastic tumors (HP:0004376)1.76583504
143B lymphocytopenia (HP:0010976)1.74097542
144Leiomyosarcoma (HP:0100243)1.72208794
145Uterine leiomyosarcoma (HP:0002891)1.72208794
146High anterior hairline (HP:0009890)1.71590102
147Urethral obstruction (HP:0000796)1.70520390
148Combined immunodeficiency (HP:0005387)1.68954502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.04344316
2WEE13.96310209
3BUB13.38815832
4NEK23.10198141
5EEF2K3.03939175
6NEK12.90552790
7TTK2.75285489
8VRK22.40031642
9CDK122.32716430
10PASK2.30045738
11RPS6KB22.12110004
12PKN22.06359763
13TSSK62.01924067
14MAP3K102.00485439
15SCYL21.99377528
16TRIM281.90816448
17TLK11.88327478
18TAF11.86921747
19PLK11.86381931
20ATR1.84621209
21SRPK11.83600257
22ACVR1B1.77238110
23EIF2AK11.76810179
24PBK1.72581268
25BRSK21.71927806
26CDK71.65528878
27SMG11.59381825
28EPHA21.57534550
29CDK41.53254846
30AURKB1.51970628
31DYRK31.51232391
32PLK31.46809483
33CHEK21.46446414
34VRK11.41680609
35TESK21.40425643
36MAP3K81.37359518
37TGFBR11.36777047
38CHEK11.36659115
39MKNK11.33971035
40STK41.27238857
41PAK41.26925056
42PDK41.26530518
43PDK31.26530518
44STK101.22630025
45FLT31.20909228
46MST41.19670987
47EIF2AK31.12807415
48AURKA1.11143711
49BRSK11.08489760
50CDK61.07989018
51EIF2AK21.06398438
52ATM1.04907242
53TESK11.04257392
54ALK1.03724390
55MAPKAPK31.02218117
56BRD41.01167370
57CCNB10.98463283
58PDK20.97582724
59CDK20.96837031
60RPS6KA40.93303263
61PIM10.91072653
62CDK30.88698302
63CDK80.86701592
64PLK40.85014596
65BRAF0.83714945
66MAP2K30.83665066
67STK30.81138066
68BCR0.79858779
69PNCK0.78670775
70MKNK20.77984058
71TRIB30.73501685
72CDK140.72589235
73CLK10.72068206
74CDK180.71818646
75CDK190.71324691
76LATS10.71031082
77MINK10.70211831
78CDK90.69628747
79MTOR0.69184585
80CDK10.68884319
81MELK0.64865868
82LIMK10.64844117
83RAF10.64010830
84NUAK10.61686770
85ZAK0.61670670
86LRRK20.61328274
87CSNK2A20.61312882
88ICK0.60351550
89MAP3K90.57450370
90KSR20.56255764
91KDR0.55375019
92PAK20.54687464
93TTN0.53925169
94ERBB30.53410793
95PLK20.52312279
96CSNK1G30.50400015
97CSNK1D0.49892700
98ARAF0.49621021
99FGFR10.49474056
100NME20.48781990
101PRKDC0.48534660
102PAK10.48350509
103STK160.45595057
104MET0.44548174
105CSNK2A10.44059784
106KSR10.43662816
107AKT20.43610131
108SIK30.40409308
109CSNK1G10.40223907
110CSNK1E0.39787029
111PRKD30.38227218
112STK38L0.37954222
113GRK60.37572952
114PAK60.37204105
115PRKCI0.34535378
116RIPK10.34370968
117CSNK1A1L0.33570256
118NEK90.32540468
119RPS6KB10.31354434
120MAPK140.30366430
121ERBB40.30079325
122NEK60.29234754
123PTK60.28794481
124CDK11A0.28714407
125AKT10.28280142
126DAPK10.27978772
127EPHA40.27803755
128RPS6KA50.27262078
129MAP2K70.25957106
130CSNK1G20.25538856
131LATS20.23661915
132PDGFRA0.22046920
133GSK3B0.21682193
134BCKDK0.21493560
135CDK150.20959390

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.39901749
2Mismatch repair_Homo sapiens_hsa034304.88150788
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40763811
4RNA transport_Homo sapiens_hsa030133.39803322
5Spliceosome_Homo sapiens_hsa030403.33694629
6Base excision repair_Homo sapiens_hsa034103.12414134
7One carbon pool by folate_Homo sapiens_hsa006703.07022540
8Cell cycle_Homo sapiens_hsa041103.01639841
9Homologous recombination_Homo sapiens_hsa034402.96299081
10Nucleotide excision repair_Homo sapiens_hsa034202.83196057
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.81260075
12Fanconi anemia pathway_Homo sapiens_hsa034602.30379022
13Ribosome_Homo sapiens_hsa030102.25084537
14mRNA surveillance pathway_Homo sapiens_hsa030152.18227163
15Non-homologous end-joining_Homo sapiens_hsa034502.16112309
16RNA polymerase_Homo sapiens_hsa030202.11526462
17Pyrimidine metabolism_Homo sapiens_hsa002402.00105863
18Systemic lupus erythematosus_Homo sapiens_hsa053221.89665703
19Proteasome_Homo sapiens_hsa030501.87111911
20RNA degradation_Homo sapiens_hsa030181.71731971
21p53 signaling pathway_Homo sapiens_hsa041151.62812863
22Basal transcription factors_Homo sapiens_hsa030221.50066312
23Vitamin B6 metabolism_Homo sapiens_hsa007501.46793270
24Oocyte meiosis_Homo sapiens_hsa041141.39454277
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29733609
26Selenocompound metabolism_Homo sapiens_hsa004501.29616813
27Biosynthesis of amino acids_Homo sapiens_hsa012301.28810492
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25186428
29Fatty acid elongation_Homo sapiens_hsa000621.23581585
30Viral carcinogenesis_Homo sapiens_hsa052031.23558075
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15451175
32Purine metabolism_Homo sapiens_hsa002301.01658563
33Epstein-Barr virus infection_Homo sapiens_hsa051691.01092427
34Antigen processing and presentation_Homo sapiens_hsa046120.96038424
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96029022
36Alcoholism_Homo sapiens_hsa050340.92753545
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91684442
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.91620529
39MicroRNAs in cancer_Homo sapiens_hsa052060.90313800
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90260095
41HTLV-I infection_Homo sapiens_hsa051660.89705023
42Propanoate metabolism_Homo sapiens_hsa006400.89209933
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88885047
44Carbon metabolism_Homo sapiens_hsa012000.84029672
45Protein export_Homo sapiens_hsa030600.81375979
46Herpes simplex infection_Homo sapiens_hsa051680.80929388
47Thyroid cancer_Homo sapiens_hsa052160.80153626
48Pentose phosphate pathway_Homo sapiens_hsa000300.79936886
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76950272
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76663001
51Hippo signaling pathway_Homo sapiens_hsa043900.75487786
52Basal cell carcinoma_Homo sapiens_hsa052170.75217993
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.71360890
54Small cell lung cancer_Homo sapiens_hsa052220.69125470
55Colorectal cancer_Homo sapiens_hsa052100.66206422
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62896389
57Steroid biosynthesis_Homo sapiens_hsa001000.59656421
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58534489
59TGF-beta signaling pathway_Homo sapiens_hsa043500.56390057
60Notch signaling pathway_Homo sapiens_hsa043300.54983850
61Pancreatic cancer_Homo sapiens_hsa052120.54977457
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.53358535
63Adherens junction_Homo sapiens_hsa045200.52169484
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51650359
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.49374752
66Legionellosis_Homo sapiens_hsa051340.46675351
67Chronic myeloid leukemia_Homo sapiens_hsa052200.46670713
68mTOR signaling pathway_Homo sapiens_hsa041500.46224884
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45919209
70HIF-1 signaling pathway_Homo sapiens_hsa040660.45414520
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44823696
72Lysine degradation_Homo sapiens_hsa003100.43085380
73Glioma_Homo sapiens_hsa052140.42011366
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41391203
75Hedgehog signaling pathway_Homo sapiens_hsa043400.40629124
76N-Glycan biosynthesis_Homo sapiens_hsa005100.40373770
77Apoptosis_Homo sapiens_hsa042100.40349670
78Fructose and mannose metabolism_Homo sapiens_hsa000510.39550386
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39321676
80Bladder cancer_Homo sapiens_hsa052190.39251026
81Renin-angiotensin system_Homo sapiens_hsa046140.38394724
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35222228
83Pathways in cancer_Homo sapiens_hsa052000.34635909
84Viral myocarditis_Homo sapiens_hsa054160.34233334
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33497980
86Tight junction_Homo sapiens_hsa045300.32890815
87Hepatitis B_Homo sapiens_hsa051610.29926741
88Fatty acid metabolism_Homo sapiens_hsa012120.29562655
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29338984
90Non-small cell lung cancer_Homo sapiens_hsa052230.28751907
91Glucagon signaling pathway_Homo sapiens_hsa049220.27774648
92Sulfur relay system_Homo sapiens_hsa041220.27530357
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27086254
94Huntingtons disease_Homo sapiens_hsa050160.27011634
95Wnt signaling pathway_Homo sapiens_hsa043100.24274252
96Proteoglycans in cancer_Homo sapiens_hsa052050.24171488
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23219134
98Shigellosis_Homo sapiens_hsa051310.22848839
99Pyruvate metabolism_Homo sapiens_hsa006200.22316118
100Endometrial cancer_Homo sapiens_hsa052130.20939201
101Prostate cancer_Homo sapiens_hsa052150.20882862
102Galactose metabolism_Homo sapiens_hsa000520.20234742
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20091888
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19890623
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19278632
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19266555
107Metabolic pathways_Homo sapiens_hsa011000.19192074
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.16879350
109FoxO signaling pathway_Homo sapiens_hsa040680.16569727
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16283434
111Vibrio cholerae infection_Homo sapiens_hsa051100.16274546
112Nitrogen metabolism_Homo sapiens_hsa009100.15453367
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15159922
114Folate biosynthesis_Homo sapiens_hsa007900.13726397
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13709996
116AMPK signaling pathway_Homo sapiens_hsa041520.13282487
117Parkinsons disease_Homo sapiens_hsa050120.13004381
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.11701145
119Acute myeloid leukemia_Homo sapiens_hsa052210.11059663
120Glutathione metabolism_Homo sapiens_hsa004800.10633397
121Melanoma_Homo sapiens_hsa052180.09749973
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08474762
123Insulin signaling pathway_Homo sapiens_hsa049100.07222716
124Influenza A_Homo sapiens_hsa051640.07098395
125Renal cell carcinoma_Homo sapiens_hsa052110.06493577
126Gap junction_Homo sapiens_hsa045400.06124248
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05548730

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