UBTD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)6.00669924
2sperm motility (GO:0030317)5.68366048
3sperm-egg recognition (GO:0035036)5.64777274
4cell wall macromolecule metabolic process (GO:0044036)5.51579427
5cell wall macromolecule catabolic process (GO:0016998)5.51579427
6binding of sperm to zona pellucida (GO:0007339)5.27912629
7barbed-end actin filament capping (GO:0051016)5.12356749
8cell-cell recognition (GO:0009988)5.05602119
9protein localization to endosome (GO:0036010)5.03596493
10acrosome assembly (GO:0001675)4.91636680
11multicellular organism reproduction (GO:0032504)4.87053722
12acrosome reaction (GO:0007340)4.70559035
13plasma membrane fusion (GO:0045026)4.51195170
14reproduction (GO:0000003)4.31762590
15synaptonemal complex assembly (GO:0007130)4.22319471
16spermatid development (GO:0007286)4.20541598
17synaptonemal complex organization (GO:0070193)4.08009470
18pinocytosis (GO:0006907)3.81422488
19stress fiber assembly (GO:0043149)3.79013238
20regulation of early endosome to late endosome transport (GO:2000641)3.65164890
21Golgi transport vesicle coating (GO:0048200)3.51916908
22COPI coating of Golgi vesicle (GO:0048205)3.51916908
23axonemal dynein complex assembly (GO:0070286)3.49466371
24protein maturation by protein folding (GO:0022417)3.48592060
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.43038783
26motile cilium assembly (GO:0044458)3.42467628
27low-density lipoprotein particle clearance (GO:0034383)3.41248024
28cellular response to arsenic-containing substance (GO:0071243)3.39505210
29hyaluronan catabolic process (GO:0030214)3.39133745
30interferon-gamma secretion (GO:0072643)3.38744099
31basement membrane organization (GO:0071711)3.32146201
32cilium or flagellum-dependent cell motility (GO:0001539)3.28597549
33substrate-dependent cell migration (GO:0006929)3.28361188
34amino sugar catabolic process (GO:0046348)3.28014686
35regulation of cilium movement (GO:0003352)3.27461616
36amyloid precursor protein catabolic process (GO:0042987)3.26189668
37tooth mineralization (GO:0034505)3.24520062
38piRNA metabolic process (GO:0034587)3.23273777
39adhesion of symbiont to host cell (GO:0044650)3.21528718
40virion attachment to host cell (GO:0019062)3.21528718
41sequestering of actin monomers (GO:0042989)3.14713722
42protein retention in ER lumen (GO:0006621)3.14163644
43natural killer cell mediated immunity (GO:0002228)3.13797625
44natural killer cell mediated cytotoxicity (GO:0042267)3.13797625
45single fertilization (GO:0007338)3.13190785
46glycosphingolipid catabolic process (GO:0046479)3.11342971
47vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.09631955
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.07322296
49endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.06486656
50male meiosis (GO:0007140)3.00677899
51decidualization (GO:0046697)3.00590721
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98237041
53positive regulation of receptor recycling (GO:0001921)2.98038175
54cell-substrate junction assembly (GO:0007044)2.96806077
55regulation of podosome assembly (GO:0071801)2.93453068
56epithelial cell-cell adhesion (GO:0090136)2.92707889
57adhesion of symbiont to host (GO:0044406)2.88108119
58adherens junction assembly (GO:0034333)2.87623758
59epithelial cilium movement (GO:0003351)2.86687180
60response to peptidoglycan (GO:0032494)2.85336706
61organic cation transport (GO:0015695)2.82077280
62neutrophil activation involved in immune response (GO:0002283)2.82041037
63pentose-phosphate shunt (GO:0006098)2.81826688
64positive regulation by symbiont of host defense response (GO:0052509)2.80806117
65modulation by symbiont of host defense response (GO:0052031)2.80806117
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80806117
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80806117
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.80806117
69modulation by symbiont of host immune response (GO:0052553)2.80806117
70negative regulation of inclusion body assembly (GO:0090084)2.79584541
71spermatogenesis (GO:0007283)2.79182543
72glial cell migration (GO:0008347)2.78668737
73male gamete generation (GO:0048232)2.78208660
74adenosine receptor signaling pathway (GO:0001973)2.78020395
75embryo implantation (GO:0007566)2.77990377
76apoptotic cell clearance (GO:0043277)2.76376290
77response to laminar fluid shear stress (GO:0034616)2.74548443
78vascular endothelial growth factor signaling pathway (GO:0038084)2.73247693
79cellular response to thyroid hormone stimulus (GO:0097067)2.73133471
80hemidesmosome assembly (GO:0031581)2.71681730
81semaphorin-plexin signaling pathway (GO:0071526)2.71392660
82response to muramyl dipeptide (GO:0032495)2.71311985
83Arp2/3 complex-mediated actin nucleation (GO:0034314)2.70042335
84glycolipid catabolic process (GO:0019377)2.69107489
85immunoglobulin mediated immune response (GO:0016064)2.68569546
86fertilization (GO:0009566)2.68512999
87regulation of membrane protein ectodomain proteolysis (GO:0051043)2.65133962
88endodermal cell differentiation (GO:0035987)2.65103301
89positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64788079
90membrane protein ectodomain proteolysis (GO:0006509)2.63729997
91cortical actin cytoskeleton organization (GO:0030866)2.63562623
92chromosome condensation (GO:0030261)2.61879128
93positive regulation of extracellular matrix organization (GO:1903055)2.61724230
94extracellular fibril organization (GO:0043206)2.61115996
95negative regulation of adherens junction organization (GO:1903392)2.60571232
96negative regulation of focal adhesion assembly (GO:0051895)2.60571232
97negative regulation of cell junction assembly (GO:1901889)2.60571232
98cell-substrate adherens junction assembly (GO:0007045)2.60554540
99focal adhesion assembly (GO:0048041)2.60554540
100retina vasculature morphogenesis in camera-type eye (GO:0061299)2.60528057
101heterochromatin organization (GO:0070828)2.60512167
102fibril organization (GO:0097435)2.59972430
103regulation of cholesterol storage (GO:0010885)2.59568810
104endothelial cell chemotaxis (GO:0035767)2.59010918
105hypotonic response (GO:0006971)2.56709804
106regulation of superoxide anion generation (GO:0032928)2.56359164
107negative regulation of smooth muscle cell migration (GO:0014912)2.55742773
108leukocyte mediated cytotoxicity (GO:0001909)2.55387510
109peptidyl-proline hydroxylation (GO:0019511)2.55357666
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55192861
111positive regulation of interferon-alpha production (GO:0032727)2.55183585
112positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55036137
113negative regulation of interleukin-8 production (GO:0032717)2.51891574
114angiogenesis involved in wound healing (GO:0060055)2.51847198
115oligosaccharide catabolic process (GO:0009313)2.51638062
116gamete generation (GO:0007276)2.51557186
117skin morphogenesis (GO:0043589)2.50695283
118respiratory burst (GO:0045730)2.50463538
119modulation by symbiont of host cellular process (GO:0044068)2.50371900
120regulation of inclusion body assembly (GO:0090083)2.50358903
121collagen metabolic process (GO:0032963)2.49389839
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48914724
123regulation of mammary gland epithelial cell proliferation (GO:0033599)2.47697206
124regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46653185
125seminiferous tubule development (GO:0072520)2.46489571
126cortical cytoskeleton organization (GO:0030865)2.46181407
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.45712075
128cell migration involved in heart development (GO:0060973)2.44502739
129collagen catabolic process (GO:0030574)2.44060416
130negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.43621576
131regulation of G0 to G1 transition (GO:0070316)2.43255632
132monoubiquitinated protein deubiquitination (GO:0035520)2.42938073
133NADPH regeneration (GO:0006740)2.42380155
134regulation of interferon-beta biosynthetic process (GO:0045357)2.42326364
135wound healing, spreading of cells (GO:0044319)2.41982693
136glucose catabolic process (GO:0006007)2.40267500
137heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.39934225
138regulation of extracellular matrix disassembly (GO:0010715)2.39666222
139regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.39574365
140sexual reproduction (GO:0019953)2.38243628
141folic acid transport (GO:0015884)2.38242545
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37796765
143response to progesterone (GO:0032570)2.37751377
144cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.37237113
145cellular copper ion homeostasis (GO:0006878)2.37232410
146regulation of interferon-alpha production (GO:0032647)2.37182248
147protein heterotrimerization (GO:0070208)2.35825288
148extracellular matrix disassembly (GO:0022617)2.35644017
149cellular response to interferon-alpha (GO:0035457)2.35146213
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.35055329
151left/right pattern formation (GO:0060972)2.34789235
152regulation of apoptotic process involved in morphogenesis (GO:1902337)2.34514121
153cellular process involved in reproduction in multicellular organism (GO:0022412)2.33766457
154protein hydroxylation (GO:0018126)2.33319139
155regulation of mononuclear cell migration (GO:0071675)2.32897900
156mannose metabolic process (GO:0006013)2.32374790
157wound healing, spreading of epidermal cells (GO:0035313)2.31988542
158response to magnesium ion (GO:0032026)2.30299227
159negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.30245476
160negative regulation of cell size (GO:0045792)2.30124784
161DNA packaging (GO:0006323)2.30004668
162cell adhesion mediated by integrin (GO:0033627)2.29705839
163negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.29548379
164response to acidic pH (GO:0010447)2.28588114
165macrophage activation involved in immune response (GO:0002281)2.27634780
166sperm capacitation (GO:0048240)2.26317819
167positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.26177412
168positive regulation of protein import into nucleus, translocation (GO:0033160)2.25881259
169membrane protein intracellular domain proteolysis (GO:0031293)2.25446387
170antigen processing and presentation via MHC class Ib (GO:0002475)2.23907866
171regulation of protein import into nucleus, translocation (GO:0033158)2.23200511
172chromosome organization involved in meiosis (GO:0070192)2.22948213
173negative regulation of fatty acid transport (GO:2000192)2.22641323
174male meiosis I (GO:0007141)2.22543440
175apoptotic process involved in morphogenesis (GO:0060561)2.22536679
176germ cell development (GO:0007281)2.22383056
177protein localization to chromosome, centromeric region (GO:0071459)2.22190919
178negative regulation of interleukin-12 production (GO:0032695)2.21942606
179antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.21467983
180antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.21467983
181negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.21001692
182T cell apoptotic process (GO:0070231)2.20875674
183polyamine biosynthetic process (GO:0006596)2.19206362
184positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.19053602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.55759251
2IRF8_21731497_ChIP-ChIP_J774_Mouse2.75055415
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67203336
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.63763403
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55503904
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.30921155
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29596981
8* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11148873
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08605675
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03384342
11IRF8_22096565_ChIP-ChIP_GC-B_Human1.95329292
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92134073
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89242657
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86510302
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84558921
16IRF8_27001747_Chip-Seq_BMDM_Mouse1.83352057
17* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80639595
18* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80024654
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.79621835
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74042662
21UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.72038345
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71044427
23ZNF263_19887448_ChIP-Seq_K562_Human1.68991018
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.68595293
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68337344
26* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68281708
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66601982
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64075096
29* ESR2_21235772_ChIP-Seq_MCF-7_Human1.61654466
30* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61444541
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60723144
32VDR_21846776_ChIP-Seq_THP-1_Human1.55272256
33* KDM2B_26808549_Chip-Seq_K562_Human1.54926953
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50583196
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47998545
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47848985
37* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47436235
38MYC_22102868_ChIP-Seq_BL_Human1.45569605
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42012155
40* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40671925
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40540589
42* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40524933
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.39906147
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39622000
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38013630
46ATF3_27146783_Chip-Seq_COLON_Human1.36936103
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.36881221
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34760029
49PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33848671
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.33543988
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33099268
52* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32988887
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32751978
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32099466
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31324266
56* SPI1_23547873_ChIP-Seq_NB4_Human1.30964946
57MAF_26560356_Chip-Seq_TH1_Human1.30391793
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.29620423
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27227109
60VDR_24763502_ChIP-Seq_THP-1_Human1.26744334
61* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26663372
62P68_20966046_ChIP-Seq_HELA_Human1.25492736
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25475880
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25318599
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24872819
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24489365
67* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23915691
68* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23868370
69LXR_22292898_ChIP-Seq_THP-1_Human1.22379111
70* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22237801
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.21373746
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20511387
73* UBF1/2_26484160_Chip-Seq_HMECs_Human1.20222149
74BCOR_27268052_Chip-Seq_Bcells_Human1.19249688
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19243825
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17346847
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17269822
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17234907
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.16741334
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16516572
81BCL6_27268052_Chip-Seq_Bcells_Human1.15463350
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.14855288
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14448047
84UTX_26944678_Chip-Seq_JUKART_Human1.13835325
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13760938
86RACK7_27058665_Chip-Seq_MCF-7_Human1.13066470
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12788163
88SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12743483
89CLOCK_20551151_ChIP-Seq_293T_Human1.12632036
90* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11964072
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.11676241
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11168476
93CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10721582
94* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10418025
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09704464
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08925371
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08658042
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08320437
99SMC4_20622854_ChIP-Seq_HELA_Human1.07519534
100CTCF_26484167_Chip-Seq_Bcells_Mouse1.07113535
101* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05942421
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05654818
103MYB_26560356_Chip-Seq_TH2_Human1.05548616
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05167094
105* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04896719
106TP53_22127205_ChIP-Seq_IMR90_Human1.03912528
107* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03611822
108CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03488466
109MYC_18555785_ChIP-Seq_MESCs_Mouse1.02338113
110MAF_26560356_Chip-Seq_TH2_Human1.01718687
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01537727
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00789031
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.00493784
114NCOR1_26117541_ChIP-Seq_K562_Human0.99975125
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.99266919
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.99266919
117MYB_26560356_Chip-Seq_TH1_Human0.99150191
118RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98410415
119TFEB_21752829_ChIP-Seq_HELA_Human0.98395077
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98230603
121SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97497496
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97445588
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96561576
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.96064549
125PHF8_20622854_ChIP-Seq_HELA_Human0.95604772
126* KDM2B_26808549_Chip-Seq_DND41_Human0.95585503
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.95527041
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95490769
129FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94953762
130CTCF_21964334_Chip-Seq_Bcells_Human0.94544986
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94107000
132RXR_22158963_ChIP-Seq_LIVER_Mouse0.93978789
133* SPI1_20517297_ChIP-Seq_HL60_Human0.93783670
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92516451
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92212683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.90788543
2MP0008438_abnormal_cutaneous_collagen3.10271454
3MP0003705_abnormal_hypodermis_morpholog3.07382080
4MP0005451_abnormal_body_composition2.40072741
5MP0008260_abnormal_autophagy2.35539629
6MP0003303_peritoneal_inflammation2.24386478
7MP0009278_abnormal_bone_marrow2.23582605
8MP0010030_abnormal_orbit_morphology2.16502580
9MP0009840_abnormal_foam_cell2.14895353
10MP0003436_decreased_susceptibility_to2.14525495
11MP0003279_aneurysm2.11147740
12MP0010368_abnormal_lymphatic_system2.05413887
13MP0003566_abnormal_cell_adhesion1.94731370
14MP0005397_hematopoietic_system_phenotyp1.91118052
15MP0001545_abnormal_hematopoietic_system1.91118052
16MP0005058_abnormal_lysosome_morphology1.90513207
17MP0005275_abnormal_skin_tensile1.82801134
18MP0004858_abnormal_nervous_system1.77280875
19MP0003075_altered_response_to1.76546524
20MP0005023_abnormal_wound_healing1.75269202
21MP0002254_reproductive_system_inflammat1.67962143
22MP0010307_abnormal_tumor_latency1.58661871
23MP0010352_gastrointestinal_tract_polyps1.58519023
24MP0005623_abnormal_meninges_morphology1.57705160
25MP0004233_abnormal_muscle_weight1.57677651
26MP0006082_CNS_inflammation1.56929960
27MP0005257_abnormal_intraocular_pressure1.56702973
28MP0000858_altered_metastatic_potential1.55725613
29MP0000750_abnormal_muscle_regeneration1.55280799
30MP0000751_myopathy1.55077126
31MP0001533_abnormal_skeleton_physiology1.54440493
32MP0003191_abnormal_cellular_cholesterol1.50973773
33MP0000733_abnormal_muscle_development1.50045418
34MP0000604_amyloidosis1.49542990
35MP0009333_abnormal_splenocyte_physiolog1.45932708
36MP0000343_altered_response_to1.44180503
37MP0002419_abnormal_innate_immunity1.44109468
38MP0009785_altered_susceptibility_to1.43474294
39MP0003448_altered_tumor_morphology1.41094557
40MP0001929_abnormal_gametogenesis1.39851812
41MP0001958_emphysema1.35328176
42MP0004808_abnormal_hematopoietic_stem1.35125749
43MP0003329_amyloid_beta_deposits1.34129168
44MP0003698_abnormal_male_reproductive1.33408108
45MP0004947_skin_inflammation1.28709140
46MP0001835_abnormal_antigen_presentation1.27450179
47MP0002877_abnormal_melanocyte_morpholog1.26502562
48MP0002796_impaired_skin_barrier1.26377396
49MP0004510_myositis1.24936552
50MP0003091_abnormal_cell_migration1.24147444
51MP0005165_increased_susceptibility_to1.23654777
52MP0005670_abnormal_white_adipose1.21668260
53MP0002405_respiratory_system_inflammati1.19919031
54MP0005025_abnormal_response_to1.18662927
55MP0003724_increased_susceptibility_to1.17967610
56MP0002896_abnormal_bone_mineralization1.17718038
57MP0002148_abnormal_hypersensitivity_rea1.17601721
58MP0000678_abnormal_parathyroid_gland1.17359174
59MP0003693_abnormal_embryo_hatching1.16561037
60MP0005076_abnormal_cell_differentiation1.16156855
61MP0005464_abnormal_platelet_physiology1.15750711
62MP0000685_abnormal_immune_system1.15363792
63MP0009053_abnormal_anal_canal1.12891287
64MP0008007_abnormal_cellular_replicative1.12495495
65MP0005000_abnormal_immune_tolerance1.11760886
66MP0002060_abnormal_skin_morphology1.10465876
67MP0003646_muscle_fatigue1.09348442
68MP0006054_spinal_hemorrhage1.09260531
69MP0005390_skeleton_phenotype1.08130660
70MP0001853_heart_inflammation1.08081072
71MP0005595_abnormal_vascular_smooth1.06592573
72MP0001542_abnormal_bone_strength1.06132553
73MP0003172_abnormal_lysosome_physiology1.04420574
74MP0002295_abnormal_pulmonary_circulatio1.04024794
75MP0002452_abnormal_antigen_presenting1.03848564
76MP0005164_abnormal_response_to1.00192831
77MP0000767_abnormal_smooth_muscle0.99458932
78MP0000747_muscle_weakness0.98378500
79MP0005503_abnormal_tendon_morphology0.97533265
80MP0003828_pulmonary_edema0.97496221
81MP0000759_abnormal_skeletal_muscle0.96643468
82MP0002998_abnormal_bone_remodeling0.95760114
83MP0005501_abnormal_skin_physiology0.93824380
84MP0005409_darkened_coat_color0.92807530
85MP0009384_cardiac_valve_regurgitation0.92737370
86MP0003011_delayed_dark_adaptation0.92345922
87MP0003186_abnormal_redox_activity0.92110026
88MP0003300_gastrointestinal_ulcer0.91917799
89MP0001915_intracranial_hemorrhage0.91276074
90MP0005375_adipose_tissue_phenotype0.90741200
91MP0001845_abnormal_inflammatory_respons0.90176664
92MP0002723_abnormal_immune_serum0.90173984
93MP0003634_abnormal_glial_cell0.87943125
94MP0003453_abnormal_keratinocyte_physiol0.87274765
95MP0008469_abnormal_protein_level0.86951736
96MP0002210_abnormal_sex_determination0.85194093
97MP0001879_abnormal_lymphatic_vessel0.84284279
98MP0005166_decreased_susceptibility_to0.82391719
99MP0003950_abnormal_plasma_membrane0.82020721
100MP0000003_abnormal_adipose_tissue0.81726131
101MP0002332_abnormal_exercise_endurance0.81667797
102MP0002161_abnormal_fertility/fecundity0.80974096
103MP0001849_ear_inflammation0.80868816
104MP0002653_abnormal_ependyma_morphology0.80630515
105MP0001819_abnormal_immune_cell0.80515276
106MP0003941_abnormal_skin_development0.80383643
107MP0000358_abnormal_cell_content/0.80193129
108MP0002420_abnormal_adaptive_immunity0.79180878
109MP0004084_abnormal_cardiac_muscle0.78997696
110MP0003795_abnormal_bone_structure0.78747659
111MP0003111_abnormal_nucleus_morphology0.78507090
112MP0005508_abnormal_skeleton_morphology0.77005640
113MP0005666_abnormal_adipose_tissue0.76717761
114MP0002933_joint_inflammation0.76120372
115MP0000490_abnormal_crypts_of0.75135212
116MP0003077_abnormal_cell_cycle0.75120565
117MP0005319_abnormal_enzyme/_coenzyme0.74931338
118MP0004272_abnormal_basement_membrane0.74908938
119MP0010234_abnormal_vibrissa_follicle0.74479523
120MP0001145_abnormal_male_reproductive0.74426137
121MP0004087_abnormal_muscle_fiber0.74022668
122MP0001243_abnormal_dermal_layer0.73878568
123MP0002282_abnormal_trachea_morphology0.73593823
124MP0002089_abnormal_postnatal_growth/wei0.73144173
125MP0002269_muscular_atrophy0.72143388
126MP0005167_abnormal_blood-brain_barrier0.72132822
127MP0001800_abnormal_humoral_immune0.72022144
128MP0005330_cardiomyopathy0.70972509
129MP0005197_abnormal_uvea_morphology0.70201977
130MP0001614_abnormal_blood_vessel0.69875832
131MP0001851_eye_inflammation0.69291351
132MP0000249_abnormal_blood_vessel0.68990364
133MP0001216_abnormal_epidermal_layer0.68611391
134MP0009764_decreased_sensitivity_to0.68491873
135MP0000689_abnormal_spleen_morphology0.67148630
136MP0004883_abnormal_blood_vessel0.66945409
137MP0004185_abnormal_adipocyte_glucose0.66504979
138MP0000749_muscle_degeneration0.66480320
139MP0002398_abnormal_bone_marrow0.65887407
140MP0010155_abnormal_intestine_physiology0.65872994
141MP0000681_abnormal_thyroid_gland0.65677722
142MP0000598_abnormal_liver_morphology0.65565398
143MP0000716_abnormal_immune_system0.65544306

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.74161210
2Abnormality of liposaccharide metabolism (HP:0010968)4.74161210
3Premature rupture of membranes (HP:0001788)4.69062812
4Protrusio acetabuli (HP:0003179)4.52650191
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.33963755
6Nasal polyposis (HP:0100582)4.33395204
7Abnormality of the nasal mucosa (HP:0000433)3.90169260
8Difficulty climbing stairs (HP:0003551)3.81788519
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.67788213
10Absent/shortened dynein arms (HP:0200106)3.67788213
11Eczematoid dermatitis (HP:0000976)3.64069812
12Peritonitis (HP:0002586)3.46059329
13Distal lower limb muscle weakness (HP:0009053)3.37086601
14Osteolytic defects of the hand bones (HP:0009699)3.30567260
15Osteolytic defects of the phalanges of the hand (HP:0009771)3.30567260
16Recurrent abscess formation (HP:0002722)3.13337909
17Increased connective tissue (HP:0009025)3.11936083
18Ankle contracture (HP:0006466)3.09895177
19Cerebral aneurysm (HP:0004944)3.06417164
20Vertebral compression fractures (HP:0002953)3.05929366
21Cervical subluxation (HP:0003308)3.04469468
22Short nail (HP:0001799)2.95715344
23Recurrent bacterial skin infections (HP:0005406)2.95400766
24Recurrent gram-negative bacterial infections (HP:0005420)2.93318350
25Nuclear cataract (HP:0100018)2.81446827
26Abnormality of polysaccharide metabolism (HP:0011012)2.77596735
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77596735
28Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77596735
29Increased variability in muscle fiber diameter (HP:0003557)2.66123238
30Infertility (HP:0000789)2.65230836
31Urinary glycosaminoglycan excretion (HP:0003541)2.64822755
32Mucopolysacchariduria (HP:0008155)2.64822755
33Ulnar deviation of the wrist (HP:0003049)2.61728202
34Systemic lupus erythematosus (HP:0002725)2.53352447
35Neurofibrillary tangles (HP:0002185)2.52475652
36Male infertility (HP:0003251)2.52221707
37Distal lower limb amyotrophy (HP:0008944)2.51789008
38Rhinitis (HP:0012384)2.51296597
39Upper motor neuron abnormality (HP:0002127)2.49872206
40Abnormality of skeletal muscle fiber size (HP:0012084)2.47876010
41Myocardial infarction (HP:0001658)2.45557294
42Muscle fiber splitting (HP:0003555)2.45460326
43Increased cerebral lipofuscin (HP:0011813)2.42595662
44Asymmetric septal hypertrophy (HP:0001670)2.42471044
45Abnormality of the Achilles tendon (HP:0005109)2.36049009
46Abnormal respiratory motile cilium physiology (HP:0012261)2.35483118
47Upper limb amyotrophy (HP:0009129)2.33799551
48Distal upper limb amyotrophy (HP:0007149)2.33799551
49Abnormal respiratory motile cilium morphology (HP:0005938)2.33556075
50Abnormal respiratory epithelium morphology (HP:0012253)2.33556075
51Vascular tortuosity (HP:0004948)2.32972568
52Chronic bronchitis (HP:0004469)2.30403149
53Hand muscle atrophy (HP:0009130)2.29463072
54Slender build (HP:0001533)2.26903490
55Axonal loss (HP:0003447)2.24935111
56Tetraparesis (HP:0002273)2.23201640
57Elevated erythrocyte sedimentation rate (HP:0003565)2.22362588
58Spinal rigidity (HP:0003306)2.21536960
59Cerebral inclusion bodies (HP:0100314)2.21357541
60Alopecia of scalp (HP:0002293)2.19496409
61Arterial tortuosity (HP:0005116)2.19431671
62Myositis (HP:0100614)2.19116294
63Soft skin (HP:0000977)2.17191362
64Abnormality of macrophages (HP:0004311)2.16564437
65Trismus (HP:0000211)2.15776376
66Pustule (HP:0200039)2.14928648
67Aortic dissection (HP:0002647)2.13535757
68Spondylolisthesis (HP:0003302)2.11823959
69Dilatation of the ascending aorta (HP:0005111)2.09774226
70Abnormality of the distal phalanges of the toes (HP:0010182)2.09576257
71Genu recurvatum (HP:0002816)2.08883268
72Stridor (HP:0010307)2.07526530
73Centrally nucleated skeletal muscle fibers (HP:0003687)2.07385870
74Atrophic scars (HP:0001075)2.06047000
75Biconcave vertebral bodies (HP:0004586)2.02997558
76Shallow orbits (HP:0000586)2.02908649
77Hyperacusis (HP:0010780)2.02858317
78Type 1 muscle fiber predominance (HP:0003803)2.02814120
79Selective tooth agenesis (HP:0001592)2.02808422
80Mildly elevated creatine phosphokinase (HP:0008180)2.02173215
81Amyloidosis (HP:0011034)2.01858091
82Degeneration of anterior horn cells (HP:0002398)2.00896609
83Abnormality of the anterior horn cell (HP:0006802)2.00896609
84Thrombocytosis (HP:0001894)2.00827345
85Mitral regurgitation (HP:0001653)2.00369451
86Bladder diverticulum (HP:0000015)1.99832330
87Bulbar palsy (HP:0001283)1.98352346
88Fragile skin (HP:0001030)1.95210607
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.94098055
90Prolonged neonatal jaundice (HP:0006579)1.92791653
91Natal tooth (HP:0000695)1.91936862
92Vacuolated lymphocytes (HP:0001922)1.91707968
93Thin bony cortex (HP:0002753)1.90529004
94Polycythemia (HP:0001901)1.89896804
95Progressive neurologic deterioration (HP:0002344)1.89504558
96Abnormality of the acetabulum (HP:0003170)1.88780194
97Aortic aneurysm (HP:0004942)1.88484383
98Orchitis (HP:0100796)1.85245481
99Wrist flexion contracture (HP:0001239)1.85080999
100Deformed sella turcica (HP:0002681)1.84243506
101Bronchitis (HP:0012387)1.83044248
102Disproportionate tall stature (HP:0001519)1.81929285
103Increased density of long bones (HP:0006392)1.81834204
104Abnormal delivery (HP:0001787)1.80459842
105Pathologic fracture (HP:0002756)1.79400142
106Long toe (HP:0010511)1.79064134
107Interstitial pulmonary disease (HP:0006530)1.78963177
108Achilles tendon contracture (HP:0001771)1.78773719
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78431464
110Nephritis (HP:0000123)1.77483251
111Abnormality of the umbilical cord (HP:0010881)1.77475700
112Dysostosis multiplex (HP:0000943)1.76540690
113Generalized amyotrophy (HP:0003700)1.75708545
114Congenital glaucoma (HP:0001087)1.75426400
115J-shaped sella turcica (HP:0002680)1.74960709
116Apathy (HP:0000741)1.74825014
117Difficulty running (HP:0009046)1.74707986
118Supranuclear gaze palsy (HP:0000605)1.73997491
119Elbow flexion contracture (HP:0002987)1.73503137
120Joint stiffness (HP:0001387)1.72869133
121Personality changes (HP:0000751)1.72691355
122Abnormality of dentin (HP:0010299)1.72226583
123Reduced subcutaneous adipose tissue (HP:0003758)1.71991885
124Mitral stenosis (HP:0001718)1.71901201
125Multiple enchondromatosis (HP:0005701)1.71755094
126Diminished motivation (HP:0000745)1.71593117
127Lower limb amyotrophy (HP:0007210)1.71217875
128Easy fatigability (HP:0003388)1.71095946
129Aneurysm (HP:0002617)1.71005570
130Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.70656514
131Bone pain (HP:0002653)1.68195864
132Wormian bones (HP:0002645)1.67756140
133Entropion (HP:0000621)1.67608612
134Distal arthrogryposis (HP:0005684)1.66627760
135Abnormality of the calcaneus (HP:0008364)1.66597426
136Blue sclerae (HP:0000592)1.66201505
137Hemorrhage of the eye (HP:0011885)1.66070520
138Ulnar bowing (HP:0003031)1.65641325
139Fatigue (HP:0012378)1.65488578
140Global brain atrophy (HP:0002283)1.65088764
141Disinhibition (HP:0000734)1.64725399
142Loss of speech (HP:0002371)1.64565859
143Nonimmune hydrops fetalis (HP:0001790)1.64531180
144Gingivitis (HP:0000230)1.64450228
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.64438937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.42778933
2PDK43.63695945
3PDK33.63695945
4TRIB33.56722902
5ERN12.99104617
6PDK22.70877569
7PIM22.47829144
8TTN2.43817153
9SMG12.28431771
10NME22.20987592
11PKN22.17948907
12RPS6KA42.12111792
13PRPF4B2.11368545
14NEK22.09464326
15LIMK11.92035873
16ICK1.90376722
17EPHB21.86246665
18PRKD31.82677485
19TBK11.82349484
20MAP2K31.77791863
21MAP3K31.74883583
22PAK41.73108433
23TESK21.43073805
24TIE11.40963442
25EEF2K1.38316597
26MAP3K111.35135428
27PTK2B1.33897005
28BMX1.30785446
29RIPK41.28162695
30PRKD21.26689926
31LMTK21.24073468
32TYK21.21667652
33MAP3K101.20131481
34RIPK11.16113067
35STK101.15758221
36STK31.15526925
37DYRK1B1.13123273
38EPHA21.11991759
39NTRK11.11336332
40MAP4K11.10912118
41LRRK21.09059803
42PIM11.08846746
43MAP3K11.08759841
44MYLK1.07611387
45TGFBR21.07487943
46CDC42BPA1.07264783
47KDR1.06926688
48BUB11.06540707
49DDR21.05783420
50RPS6KA21.04612655
51KIT1.04235628
52MAPKAPK30.99838832
53MARK30.99185268
54MOS0.99095954
55ZAP700.97652791
56BLK0.96999789
57LATS20.96914106
58TAOK10.91405117
59PAK20.90729589
60BRAF0.88290765
61ABL20.87608268
62DYRK30.86943612
63IRAK40.86704698
64MST1R0.84741573
65WEE10.83845159
66PTK60.83358179
67MAP3K60.83152921
68PAK10.82562450
69MAP3K80.81616048
70IKBKB0.80786199
71JAK30.79173166
72EPHB10.77617673
73NEK90.77429588
74TRPM70.76026383
75STK160.72740003
76MAP3K50.72720339
77PBK0.71591993
78TAOK20.71481089
79KSR20.71248389
80ARAF0.71103503
81IRAK20.70085071
82CSK0.69349902
83STK380.66844706
84MTOR0.65362188
85ROCK20.65102998
86MAP3K140.64878138
87SCYL20.64396243
88FGR0.63579572
89ERBB40.63073946
90MARK20.63019246
91MAP3K130.60437467
92PDGFRA0.58821825
93TTK0.57612705
94DMPK0.57397561
95CDK40.56835593
96IRAK30.56805959
97MET0.56016323
98CDK60.54560479
99ILK0.53669513
100CSF1R0.52490907
101MATK0.52481321
102MAP2K20.51546433
103PDPK10.49186793
104PTK20.47759548
105PDK10.47584554
106PAK60.47278475
107FLT30.47089175
108DAPK30.46784762
109GRK70.46365316
110CHUK0.46165472
111GSK3A0.44997833
112PRKG20.44129748
113PIK3CG0.43667098
114CAMK2G0.43023727
115CAMK1D0.40505046
116MAPKAPK20.39358687
117PDGFRB0.38586473
118EIF2AK30.37990657
119IKBKE0.37766701
120HCK0.36665738
121ROCK10.36548445
122RPS6KA60.36108401
123NEK10.36037280
124PRKD10.35707147
125BCKDK0.35048919
126BRSK20.34669171
127SIK10.34020556
128JAK10.33187036
129PLK10.32836875
130EIF2AK10.30898891
131MAPK120.28412571
132LATS10.27841940
133AKT20.27821024
134RPS6KC10.27793643
135RPS6KL10.27793643
136AURKA0.27661170
137MAPK40.27131133
138MAPK70.26321310
139FGFR40.24428488

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.75042429
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.28840985
3Legionellosis_Homo sapiens_hsa051342.21225743
4Leishmaniasis_Homo sapiens_hsa051402.10666440
5Pentose phosphate pathway_Homo sapiens_hsa000301.94221582
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.81409310
7Staphylococcus aureus infection_Homo sapiens_hsa051501.75454577
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.69214630
9Lysosome_Homo sapiens_hsa041421.68127850
10Vibrio cholerae infection_Homo sapiens_hsa051101.64029461
11Prion diseases_Homo sapiens_hsa050201.62769800
12Malaria_Homo sapiens_hsa051441.61880352
13Shigellosis_Homo sapiens_hsa051311.59752787
14Osteoclast differentiation_Homo sapiens_hsa043801.56367936
15Antigen processing and presentation_Homo sapiens_hsa046121.51658282
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49751797
17p53 signaling pathway_Homo sapiens_hsa041151.45621422
18Toxoplasmosis_Homo sapiens_hsa051451.44199353
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41712968
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38800046
21Notch signaling pathway_Homo sapiens_hsa043301.35907785
22Tuberculosis_Homo sapiens_hsa051521.35876861
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34270773
24Salmonella infection_Homo sapiens_hsa051321.34064661
25Apoptosis_Homo sapiens_hsa042101.33108681
26TNF signaling pathway_Homo sapiens_hsa046681.32051251
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31631673
28Proteasome_Homo sapiens_hsa030501.24474556
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23829531
30Other glycan degradation_Homo sapiens_hsa005111.21588098
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21547830
32Phagosome_Homo sapiens_hsa041451.20883390
33Measles_Homo sapiens_hsa051621.20877936
34Influenza A_Homo sapiens_hsa051641.20051241
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19228631
36Sulfur relay system_Homo sapiens_hsa041221.18347018
37RNA transport_Homo sapiens_hsa030131.18279296
38Small cell lung cancer_Homo sapiens_hsa052221.18173014
39HIF-1 signaling pathway_Homo sapiens_hsa040661.16117095
40Amoebiasis_Homo sapiens_hsa051461.15357687
41Pertussis_Homo sapiens_hsa051331.14173357
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11977529
43Bladder cancer_Homo sapiens_hsa052191.11169649
44Herpes simplex infection_Homo sapiens_hsa051681.09892582
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.08455665
46ECM-receptor interaction_Homo sapiens_hsa045121.07110814
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04844296
48Fructose and mannose metabolism_Homo sapiens_hsa000511.03989905
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.03536170
50Pancreatic cancer_Homo sapiens_hsa052121.03234710
51Selenocompound metabolism_Homo sapiens_hsa004501.01603538
52Chronic myeloid leukemia_Homo sapiens_hsa052201.01206364
53Focal adhesion_Homo sapiens_hsa045100.98709377
54Acute myeloid leukemia_Homo sapiens_hsa052210.98279115
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95865309
56Epstein-Barr virus infection_Homo sapiens_hsa051690.94250498
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92677815
58Viral carcinogenesis_Homo sapiens_hsa052030.92267516
59Biosynthesis of amino acids_Homo sapiens_hsa012300.92029127
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.91831039
61Carbon metabolism_Homo sapiens_hsa012000.91329814
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.91012879
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.90342228
64Renal cell carcinoma_Homo sapiens_hsa052110.90006384
65Fatty acid biosynthesis_Homo sapiens_hsa000610.88795578
66Viral myocarditis_Homo sapiens_hsa054160.88636148
67B cell receptor signaling pathway_Homo sapiens_hsa046620.88104759
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87098901
69Sphingolipid metabolism_Homo sapiens_hsa006000.84464904
70Proteoglycans in cancer_Homo sapiens_hsa052050.84014132
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81719649
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79781731
73Sulfur metabolism_Homo sapiens_hsa009200.79773188
74Dilated cardiomyopathy_Homo sapiens_hsa054140.79224324
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78565520
76Hepatitis C_Homo sapiens_hsa051600.78185503
77VEGF signaling pathway_Homo sapiens_hsa043700.77814843
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.77457375
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76251874
80HTLV-I infection_Homo sapiens_hsa051660.75937509
81Glutathione metabolism_Homo sapiens_hsa004800.75903246
82Hepatitis B_Homo sapiens_hsa051610.75569522
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74202808
84Galactose metabolism_Homo sapiens_hsa000520.73922831
85Insulin signaling pathway_Homo sapiens_hsa049100.73307386
86Rheumatoid arthritis_Homo sapiens_hsa053230.73260144
87Cell cycle_Homo sapiens_hsa041100.72545638
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71930374
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69305695
90Endometrial cancer_Homo sapiens_hsa052130.68617754
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68461949
92Non-small cell lung cancer_Homo sapiens_hsa052230.67434178
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67218529
94Pyrimidine metabolism_Homo sapiens_hsa002400.66342443
95Thyroid cancer_Homo sapiens_hsa052160.65191351
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64986876
97Endocytosis_Homo sapiens_hsa041440.64513086
98Collecting duct acid secretion_Homo sapiens_hsa049660.64176911
99GnRH signaling pathway_Homo sapiens_hsa049120.64033325
100DNA replication_Homo sapiens_hsa030300.63982399
101PPAR signaling pathway_Homo sapiens_hsa033200.63137300
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.62381665
103Glioma_Homo sapiens_hsa052140.60967151
104Complement and coagulation cascades_Homo sapiens_hsa046100.60705534
105Base excision repair_Homo sapiens_hsa034100.59694057
106Adherens junction_Homo sapiens_hsa045200.59475320
107Caffeine metabolism_Homo sapiens_hsa002320.59065303
108Rap1 signaling pathway_Homo sapiens_hsa040150.58874749
109Mineral absorption_Homo sapiens_hsa049780.55688219
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.54544587
111Hematopoietic cell lineage_Homo sapiens_hsa046400.54369013
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54203189
113Pathways in cancer_Homo sapiens_hsa052000.53525630
114Fatty acid elongation_Homo sapiens_hsa000620.53470742
115Renin-angiotensin system_Homo sapiens_hsa046140.53054966
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52978121
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52895176
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52667072
119Folate biosynthesis_Homo sapiens_hsa007900.52011669
120Synaptic vesicle cycle_Homo sapiens_hsa047210.51430078
121Insulin resistance_Homo sapiens_hsa049310.51257508
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50285917
123AMPK signaling pathway_Homo sapiens_hsa041520.49729331
124N-Glycan biosynthesis_Homo sapiens_hsa005100.48921069
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47914274
126Asthma_Homo sapiens_hsa053100.47556774
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45935540
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45332990
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.44926336
130Basal transcription factors_Homo sapiens_hsa030220.44234781
131MicroRNAs in cancer_Homo sapiens_hsa052060.43833196
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43289754
133mTOR signaling pathway_Homo sapiens_hsa041500.43265741
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43137250
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43077035
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.42773010

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »