UBTD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)5.38164794
2paraxial mesoderm development (GO:0048339)3.99208661
3notochord development (GO:0030903)3.65780188
4positive regulation of cell cycle G2/M phase transition (GO:1902751)3.50532806
5positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.50532806
6regulation of NFAT protein import into nucleus (GO:0051532)3.49639223
7positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.44741186
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.43368479
9positive regulation of DNA-templated transcription, initiation (GO:2000144)3.42115745
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41500011
11regulation of RNA export from nucleus (GO:0046831)3.38305481
12pre-miRNA processing (GO:0031054)3.31333271
13nuclear pore complex assembly (GO:0051292)3.31072488
14nuclear pore organization (GO:0006999)3.27130448
15hippo signaling (GO:0035329)3.26767063
16axon extension involved in axon guidance (GO:0048846)3.22723894
17neuron projection extension involved in neuron projection guidance (GO:1902284)3.22723894
18axon extension (GO:0048675)3.20065010
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18498043
20regulation of establishment of planar polarity (GO:0090175)3.11747646
21peptidyl-arginine omega-N-methylation (GO:0035247)3.09852040
22positive regulation of gastrulation (GO:2000543)3.03114618
23glucocorticoid receptor signaling pathway (GO:0042921)3.01368373
24apical protein localization (GO:0045176)3.00975621
25outer ear morphogenesis (GO:0042473)2.99791092
26inner ear receptor cell development (GO:0060119)2.94262185
27peptidyl-arginine methylation (GO:0018216)2.92602574
28peptidyl-arginine N-methylation (GO:0035246)2.92602574
29limb bud formation (GO:0060174)2.92569051
30establishment of planar polarity (GO:0001736)2.91868114
31establishment of tissue polarity (GO:0007164)2.91868114
32heterochromatin organization (GO:0070828)2.88357012
33cerebral cortex radially oriented cell migration (GO:0021799)2.88084001
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87182002
35lateral sprouting from an epithelium (GO:0060601)2.85912976
36hematopoietic stem cell proliferation (GO:0071425)2.85048963
37response to parathyroid hormone (GO:0071107)2.85027387
38neuron projection extension (GO:1990138)2.83540033
39mitotic chromosome condensation (GO:0007076)2.77248473
40neuron recognition (GO:0008038)2.76050683
41G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.75925752
42body morphogenesis (GO:0010171)2.75038851
43protein heterotrimerization (GO:0070208)2.74027717
44cellular protein complex localization (GO:0034629)2.69742619
45regulation of DNA-templated transcription, initiation (GO:2000142)2.69646615
46regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.69556001
47positive regulation of smoothened signaling pathway (GO:0045880)2.69462961
48axonal fasciculation (GO:0007413)2.69016592
49embryonic body morphogenesis (GO:0010172)2.68647387
50non-canonical Wnt signaling pathway (GO:0035567)2.67731480
51protein localization to chromosome, centromeric region (GO:0071459)2.67123324
52nucleosome disassembly (GO:0006337)2.66177196
53protein-DNA complex disassembly (GO:0032986)2.66177196
54presynaptic membrane assembly (GO:0097105)2.65828235
55intracellular estrogen receptor signaling pathway (GO:0030520)2.65097550
56regulation of mesoderm development (GO:2000380)2.64426515
57establishment of integrated proviral latency (GO:0075713)2.63712336
58regulation of sister chromatid cohesion (GO:0007063)2.61687796
59negative regulation of chromosome segregation (GO:0051985)2.61534394
60regulation of nuclear cell cycle DNA replication (GO:0033262)2.60186032
61positive regulation of DNA-dependent DNA replication (GO:2000105)2.59355115
62mitotic sister chromatid cohesion (GO:0007064)2.59082449
63chondrocyte proliferation (GO:0035988)2.59070998
64camera-type eye morphogenesis (GO:0048593)2.58021536
65negative regulation of mitotic sister chromatid separation (GO:2000816)2.57693141
66negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57693141
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57693141
68negative regulation of sister chromatid segregation (GO:0033046)2.57693141
69lung-associated mesenchyme development (GO:0060484)2.56355278
70urogenital system development (GO:0001655)2.56192266
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.55802402
72histone arginine methylation (GO:0034969)2.54743585
73regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.54458754
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53826002
75positive regulation of mitotic sister chromatid separation (GO:1901970)2.53826002
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53826002
77regulation of nucleobase-containing compound transport (GO:0032239)2.53524949
78NLS-bearing protein import into nucleus (GO:0006607)2.52301703
79anterior/posterior axis specification, embryo (GO:0008595)2.52263688
80microtubule depolymerization (GO:0007019)2.52175179
81monoubiquitinated protein deubiquitination (GO:0035520)2.51453926
82regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51077619
83mitotic spindle assembly checkpoint (GO:0007094)2.49333207
84regulation of chromosome segregation (GO:0051983)2.47846485
85chromosome condensation (GO:0030261)2.47573202
86negative regulation of catenin import into nucleus (GO:0035414)2.47518867
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.47440874
88spindle assembly checkpoint (GO:0071173)2.47286197
89somite development (GO:0061053)2.46460063
90protein complex localization (GO:0031503)2.45874386
91dorsal/ventral axis specification (GO:0009950)2.45837412
92regulation of sister chromatid segregation (GO:0033045)2.45521960
93regulation of mitotic sister chromatid separation (GO:0010965)2.45521960
94regulation of mitotic sister chromatid segregation (GO:0033047)2.45521960
95embryonic foregut morphogenesis (GO:0048617)2.45439557
96pyrimidine nucleobase catabolic process (GO:0006208)2.45081648
97negative regulation of chondrocyte differentiation (GO:0032331)2.44871574
98lens fiber cell development (GO:0070307)2.44272373
99collagen fibril organization (GO:0030199)2.44206480
100cochlea morphogenesis (GO:0090103)2.44164352
101developmental cell growth (GO:0048588)2.43741174
102negative regulation of DNA repair (GO:0045738)2.43712203
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.43305766
104mitotic metaphase plate congression (GO:0007080)2.43013984
105protein localization to kinetochore (GO:0034501)2.42930019
106retina vasculature morphogenesis in camera-type eye (GO:0061299)2.42721579
107regulation of mitotic spindle organization (GO:0060236)2.42702816
108artery development (GO:0060840)2.42565122
109regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.40869197
110establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.40615158
111corticosteroid receptor signaling pathway (GO:0031958)2.39873108
112cell surface receptor signaling pathway involved in heart development (GO:0061311)2.39856758
113asymmetric protein localization (GO:0008105)2.39029094
114convergent extension (GO:0060026)2.38969169
115lens morphogenesis in camera-type eye (GO:0002089)2.38741555
116regulation of SMAD protein import into nucleus (GO:0060390)2.38546279
117regulation of spindle organization (GO:0090224)2.38142182
118regulation of catenin import into nucleus (GO:0035412)2.37650147
119ectodermal placode formation (GO:0060788)2.37495402
120post-anal tail morphogenesis (GO:0036342)2.37017473
121DNA unwinding involved in DNA replication (GO:0006268)2.36973634
122regulation of cell cycle G2/M phase transition (GO:1902749)2.36702468
123embryonic hindlimb morphogenesis (GO:0035116)2.36565651
124negative regulation of embryonic development (GO:0045992)2.35954071
125DNA replication-dependent nucleosome assembly (GO:0006335)2.35850716
126DNA replication-dependent nucleosome organization (GO:0034723)2.35850716
127negative regulation of cell fate specification (GO:0009996)2.35846502
128cell migration involved in sprouting angiogenesis (GO:0002042)2.34912622
129regulation of DNA damage checkpoint (GO:2000001)2.34912134
130mitotic spindle checkpoint (GO:0071174)2.34757571
131protein localization to chromosome (GO:0034502)2.34745970
132hindlimb morphogenesis (GO:0035137)2.33839665
133branching involved in salivary gland morphogenesis (GO:0060445)2.33758353
134negative regulation of cartilage development (GO:0061037)2.33506595
135Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32243230
136regulation of DNA methylation (GO:0044030)2.32216624
137regulation of hair follicle development (GO:0051797)2.31906658
138gastrulation with mouth forming second (GO:0001702)2.31569428
139positive regulation of SMAD protein import into nucleus (GO:0060391)2.31380467
140sister chromatid segregation (GO:0000819)2.30982979
141sperm-egg recognition (GO:0035036)2.30797223
142metanephric mesenchyme development (GO:0072075)2.30721678
143kinetochore organization (GO:0051383)2.30177929
144embryonic cranial skeleton morphogenesis (GO:0048701)2.29226631
145negative chemotaxis (GO:0050919)2.27677197
146ganglion development (GO:0061548)2.27269575
147negative regulation of vascular permeability (GO:0043116)2.26891828
148cerebral cortex cell migration (GO:0021795)2.26649149
149positive regulation of catenin import into nucleus (GO:0035413)2.26601539
150neuronal stem cell maintenance (GO:0097150)2.25452378
151epithelial tube branching involved in lung morphogenesis (GO:0060441)2.24296767
152establishment or maintenance of apical/basal cell polarity (GO:0035088)2.23739095
153establishment or maintenance of bipolar cell polarity (GO:0061245)2.23739095
154ATP-dependent chromatin remodeling (GO:0043044)2.23686367
155establishment of monopolar cell polarity (GO:0061162)2.22208286
156establishment or maintenance of monopolar cell polarity (GO:0061339)2.22208286
157regulation of transforming growth factor beta2 production (GO:0032909)2.21371692
158skeletal muscle organ development (GO:0060538)2.21338841
159mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.21148275
160chondrocyte development (GO:0002063)2.21098697
161craniofacial suture morphogenesis (GO:0097094)2.20487646
162chromatin remodeling at centromere (GO:0031055)2.19799644
163embryonic retina morphogenesis in camera-type eye (GO:0060059)2.19565469
164heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.17563194
165regulation of centriole replication (GO:0046599)2.16528532
166regulation of cell fate specification (GO:0042659)2.16162770
167mesenchymal cell differentiation (GO:0048762)2.14605945
168histone H2B ubiquitination (GO:0033523)2.14363387
169generation of neurons (GO:0048699)2.13988077
170mesenchymal to epithelial transition (GO:0060231)2.13432531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.47976676
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.42702977
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.11642837
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.15103046
5EZH2_22144423_ChIP-Seq_EOC_Human2.92909852
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83670158
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.81914003
8HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.72137617
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.71582578
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.65474903
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51882987
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42267592
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.40549591
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.32574225
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.29491274
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.23475603
17AR_21909140_ChIP-Seq_LNCAP_Human2.22369380
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21468540
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.09249367
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85971596
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85971596
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85971596
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83300016
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83163686
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79306705
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.74740505
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74729027
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.73687095
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72678374
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72620343
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71859963
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.66824905
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66516674
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66490158
35* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.65492775
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61263197
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53992221
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52230998
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49562047
40ZNF274_21170338_ChIP-Seq_K562_Hela1.47205495
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47117639
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45051118
43FUS_26573619_Chip-Seq_HEK293_Human1.42996141
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42608176
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.40934551
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40905537
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40524048
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.39200508
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38586500
50TP53_18474530_ChIP-ChIP_U2OS_Human1.38410766
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.37792270
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37223008
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36134753
54CLOCK_20551151_ChIP-Seq_293T_Human1.35541489
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35407481
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34521636
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34106492
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33762866
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33353234
60* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32622788
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31582921
62* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31420292
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27161483
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26870627
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26146467
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.25462997
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25295256
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.25109570
69TAF15_26573619_Chip-Seq_HEK293_Human1.24424702
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21834810
71* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19783881
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.19493526
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.19306999
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19092574
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19003813
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19003813
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18983684
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.18647928
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17621565
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17211793
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16302339
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15738284
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14950988
84RNF2_27304074_Chip-Seq_NSC_Mouse1.14427870
85* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14370860
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13963627
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13678429
88* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12164909
89P300_19829295_ChIP-Seq_ESCs_Human1.11436359
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10923719
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10535388
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09807050
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09690277
94* BRD4_25478319_ChIP-Seq_HGPS_Human1.09052284
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08496064
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07797333
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07386373
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07288092
99XRN2_22483619_ChIP-Seq_HELA_Human1.07244116
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06757243
101* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06743055
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06593318
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04139455
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.04024003
105GBX2_23144817_ChIP-Seq_PC3_Human1.03972173
106GF1B_26923725_Chip-Seq_HPCs_Mouse1.03419722
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02974077
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01568846
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.01212472
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01050650
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00946166
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99455324
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.99371880
114ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98481971
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95408360
116TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95341560
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94301304
118RNF2_27304074_Chip-Seq_ESCs_Mouse0.94180315
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93308502
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92977453
121ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91597418
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90945146
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90267060
124SOX9_26525672_Chip-Seq_HEART_Mouse0.89910940
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89782025
126MYC_22102868_ChIP-Seq_BL_Human0.89148102
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88477994
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88076505
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87367898
130TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87183977
131TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87142646
132EED_16625203_ChIP-ChIP_MESCs_Mouse0.86456626
133TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84634070
134UBF1/2_26484160_Chip-Seq_HMECs_Human0.83246058
135* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83187966
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82913023
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82829648
138NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82082735
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81869336
140EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81381547
141RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81381547
142* RING1B_27294783_Chip-Seq_ESCs_Mouse0.80422582
143TRIM28_21343339_ChIP-Seq_HEK293_Human0.80074015
144* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.79485645
145POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79235933
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79138929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.11736090
2MP0010030_abnormal_orbit_morphology3.07145443
3MP0005503_abnormal_tendon_morphology2.97788689
4MP0008057_abnormal_DNA_replication2.74750879
5MP0002102_abnormal_ear_morphology2.69157075
6MP0003123_paternal_imprinting2.58448293
7MP0003705_abnormal_hypodermis_morpholog2.51925509
8MP0009053_abnormal_anal_canal2.43147722
9MP0000537_abnormal_urethra_morphology2.41261513
10MP0003283_abnormal_digestive_organ2.37099317
11MP0000778_abnormal_nervous_system2.24030427
12MP0005275_abnormal_skin_tensile2.20174209
13MP0005623_abnormal_meninges_morphology2.06876863
14MP0003122_maternal_imprinting1.95376674
15MP0003121_genomic_imprinting1.85920405
16MP0009379_abnormal_foot_pigmentation1.82994966
17MP0003890_abnormal_embryonic-extraembry1.81936146
18MP0003385_abnormal_body_wall1.81508060
19MP0003119_abnormal_digestive_system1.73826699
20MP0000049_abnormal_middle_ear1.71619723
21MP0003942_abnormal_urinary_system1.67504069
22MP0003937_abnormal_limbs/digits/tail_de1.63909918
23MP0002282_abnormal_trachea_morphology1.63507869
24MP0005076_abnormal_cell_differentiation1.62209646
25MP0005257_abnormal_intraocular_pressure1.59164907
26MP0003111_abnormal_nucleus_morphology1.58950293
27MP0003115_abnormal_respiratory_system1.58068786
28MP0010094_abnormal_chromosome_stability1.58008074
29MP0000428_abnormal_craniofacial_morphol1.52972983
30MP0003755_abnormal_palate_morphology1.52160905
31MP0001293_anophthalmia1.51726062
32MP0000733_abnormal_muscle_development1.48956296
33MP0009250_abnormal_appendicular_skeleto1.48815293
34MP0005508_abnormal_skeleton_morphology1.46776078
35MP0009384_cardiac_valve_regurgitation1.45294882
36MP0000569_abnormal_digit_pigmentation1.44784275
37MP0005410_abnormal_fertilization1.42398003
38MP0008007_abnormal_cellular_replicative1.41808162
39MP0004957_abnormal_blastocyst_morpholog1.40642270
40MP0003077_abnormal_cell_cycle1.39856454
41MP0002938_white_spotting1.39539632
42MP0008932_abnormal_embryonic_tissue1.39107683
43MP0005248_abnormal_Harderian_gland1.38807794
44MP0004233_abnormal_muscle_weight1.38454189
45MP0000516_abnormal_urinary_system1.38401120
46MP0005367_renal/urinary_system_phenotyp1.38401120
47MP0004197_abnormal_fetal_growth/weight/1.37778350
48MP0003935_abnormal_craniofacial_develop1.37427967
49MP0002084_abnormal_developmental_patter1.37325279
50MP0002932_abnormal_joint_morphology1.37012041
51MP0010352_gastrointestinal_tract_polyps1.36773766
52MP0002085_abnormal_embryonic_tissue1.33211190
53MP0005197_abnormal_uvea_morphology1.32593446
54MP0000566_synostosis1.32480891
55MP0003941_abnormal_skin_development1.31906747
56MP0002116_abnormal_craniofacial_bone1.30704420
57MP0002249_abnormal_larynx_morphology1.30599836
58MP0000534_abnormal_ureter_morphology1.28199758
59MP0001346_abnormal_lacrimal_gland1.26873106
60MP0000762_abnormal_tongue_morphology1.26054562
61MP0000678_abnormal_parathyroid_gland1.23616734
62MP0001730_embryonic_growth_arrest1.23432672
63MP0005409_darkened_coat_color1.23344448
64MP0002108_abnormal_muscle_morphology1.22727930
65MP0003567_abnormal_fetal_cardiomyocyte1.22618911
66MP0003693_abnormal_embryo_hatching1.22095910
67MP0001188_hyperpigmentation1.21845649
68MP0000350_abnormal_cell_proliferation1.18942488
69MP0005380_embryogenesis_phenotype1.17973847
70MP0001672_abnormal_embryogenesis/_devel1.17973847
71MP0002233_abnormal_nose_morphology1.17711043
72MP0003279_aneurysm1.16617646
73MP0001697_abnormal_embryo_size1.15242744
74MP0008058_abnormal_DNA_repair1.14504016
75MP0002234_abnormal_pharynx_morphology1.13352446
76MP0003861_abnormal_nervous_system1.13137209
77MP0003938_abnormal_ear_development1.12717867
78MP0008789_abnormal_olfactory_epithelium1.12664959
79MP0000432_abnormal_head_morphology1.12411863
80MP0002081_perinatal_lethality1.11237816
81MP0001299_abnormal_eye_distance/1.09871479
82MP0000579_abnormal_nail_morphology1.06254446
83MP0004272_abnormal_basement_membrane1.06180352
84MP0003984_embryonic_growth_retardation1.05425371
85MP0002088_abnormal_embryonic_growth/wei1.04720567
86MP0000955_abnormal_spinal_cord1.04688302
87MP0008877_abnormal_DNA_methylation1.02907477
88MP0010368_abnormal_lymphatic_system1.02526891
89MP0006054_spinal_hemorrhage1.01866252
90MP0004270_analgesia1.01044032
91MP0001958_emphysema1.00708392
92MP0002109_abnormal_limb_morphology0.99219958
93MP0002653_abnormal_ependyma_morphology0.98428355
94MP0002114_abnormal_axial_skeleton0.97995936
95MP0009672_abnormal_birth_weight0.97501996
96MP0001286_abnormal_eye_development0.97469950
97MP0002896_abnormal_bone_mineralization0.97342597
98MP0002184_abnormal_innervation0.97239218
99MP0002089_abnormal_postnatal_growth/wei0.96536230
100MP0002697_abnormal_eye_size0.96381434
101MP0005187_abnormal_penis_morphology0.96321105
102MP0002092_abnormal_eye_morphology0.95252168
103MP0001177_atelectasis0.94957398
104MP0009703_decreased_birth_body0.93981443
105MP0001849_ear_inflammation0.93763728
106MP0002111_abnormal_tail_morphology0.93743044
107MP0003091_abnormal_cell_migration0.93471117
108MP0002152_abnormal_brain_morphology0.92382036
109MP0000163_abnormal_cartilage_morphology0.91301302
110MP0010307_abnormal_tumor_latency0.89789723
111MP0002086_abnormal_extraembryonic_tissu0.89773826
112MP0004133_heterotaxia0.89208059
113MP0003315_abnormal_perineum_morphology0.89197981
114MP0000750_abnormal_muscle_regeneration0.86958627
115MP0002751_abnormal_autonomic_nervous0.86926492
116MP0002177_abnormal_outer_ear0.86161620
117MP0006072_abnormal_retinal_apoptosis0.85627106
118MP0005499_abnormal_olfactory_system0.84868303
119MP0005394_taste/olfaction_phenotype0.84868303
120MP0006292_abnormal_olfactory_placode0.84152038
121MP0002822_catalepsy0.82595089
122MP0001879_abnormal_lymphatic_vessel0.82477215
123MP0005391_vision/eye_phenotype0.82134414
124MP0005193_abnormal_anterior_eye0.81104033
125MP0004858_abnormal_nervous_system0.80906813
126MP0001340_abnormal_eyelid_morphology0.80675848
127MP0000026_abnormal_inner_ear0.79866799

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.16230527
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.16230527
3Protrusio acetabuli (HP:0003179)4.07065509
4Shallow orbits (HP:0000586)3.56229061
5Abnormality of the 4th metacarpal (HP:0010012)3.19464297
6Oligodactyly (HP:0012165)3.12814793
7Septo-optic dysplasia (HP:0100842)3.12359361
8Oligodactyly (hands) (HP:0001180)3.03508705
9Renal duplication (HP:0000075)2.84143230
10Premature rupture of membranes (HP:0001788)2.80805688
11Cortical dysplasia (HP:0002539)2.69652804
12Microglossia (HP:0000171)2.63387529
13Ankle contracture (HP:0006466)2.57769910
14Bladder diverticulum (HP:0000015)2.51578095
15Partial duplication of thumb phalanx (HP:0009944)2.47322767
16Partial duplication of the phalanx of hand (HP:0009999)2.42219313
17Macroorchidism (HP:0000053)2.35848638
18Wrist flexion contracture (HP:0001239)2.34588688
19Trigonocephaly (HP:0000243)2.33917385
20Genu recurvatum (HP:0002816)2.33883002
21Abdominal situs inversus (HP:0003363)2.31285029
22Abnormality of abdominal situs (HP:0011620)2.31285029
23Split foot (HP:0001839)2.29937509
24Arnold-Chiari malformation (HP:0002308)2.28022064
25Insidious onset (HP:0003587)2.27058878
26Termporal pattern (HP:0011008)2.27058878
27Absent septum pellucidum (HP:0001331)2.24957468
28Bowel diverticulosis (HP:0005222)2.24492582
29Abnormality of the septum pellucidum (HP:0007375)2.23351688
30Soft skin (HP:0000977)2.23182730
31Abnormal number of incisors (HP:0011064)2.21074058
32Mild short stature (HP:0003502)2.20618727
33Arterial tortuosity (HP:0005116)2.19664301
34Myelomeningocele (HP:0002475)2.17265864
35Mesomelia (HP:0003027)2.15881723
36Broad thumb (HP:0011304)2.15505513
37Cutaneous syndactyly (HP:0012725)2.15324623
38Missing ribs (HP:0000921)2.12960566
39Deviation of the hallux (HP:0010051)2.11754964
40Dilatation of the ascending aorta (HP:0005111)2.11293799
41Hepatoblastoma (HP:0002884)2.09931981
42Overriding aorta (HP:0002623)2.08834689
43Cutaneous finger syndactyly (HP:0010554)2.07493591
44Broad phalanges of the hand (HP:0009768)2.06059742
45Broad long bones (HP:0005622)2.03810703
46Abnormality of the distal phalanx of the thumb (HP:0009617)2.01281745
47Neonatal short-limb short stature (HP:0008921)2.00924268
48Selective tooth agenesis (HP:0001592)2.00213611
49Hallux valgus (HP:0001822)1.98731368
50Maternal diabetes (HP:0009800)1.98504448
51Broad palm (HP:0001169)1.97013103
52Broad phalanx (HP:0006009)1.96082998
53Increased nuchal translucency (HP:0010880)1.94710077
54Large earlobe (HP:0009748)1.92528083
55Papillary thyroid carcinoma (HP:0002895)1.91265927
56Broad finger (HP:0001500)1.91243663
57Abnormality of dentin (HP:0010299)1.91148132
58Omphalocele (HP:0001539)1.90603577
59Choanal stenosis (HP:0000452)1.89826031
60Short middle phalanx of the 5th finger (HP:0004220)1.89404955
61Asymmetry of the thorax (HP:0001555)1.86826616
62Wide anterior fontanel (HP:0000260)1.85621191
63Spinal cord lesions (HP:0100561)1.85559906
64Syringomyelia (HP:0003396)1.85559906
65Duplication of thumb phalanx (HP:0009942)1.84170777
66Midline defect of the nose (HP:0004122)1.83561465
67Atrophic scars (HP:0001075)1.82879151
68Wormian bones (HP:0002645)1.82824049
69Pendular nystagmus (HP:0012043)1.81808643
70Facial cleft (HP:0002006)1.81562777
71Long eyelashes (HP:0000527)1.80547039
72Aortic aneurysm (HP:0004942)1.80289255
73Turricephaly (HP:0000262)1.80097153
74Renovascular hypertension (HP:0100817)1.79096441
75Pelvic girdle muscle weakness (HP:0003749)1.78962050
76Facial hemangioma (HP:0000329)1.78862311
77Abnormality of the calcaneus (HP:0008364)1.78568350
78Vertebral clefting (HP:0008428)1.78473494
79Abnormality of the parietal bone (HP:0002696)1.78346721
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.77046895
81Aplasia involving bones of the upper limbs (HP:0009823)1.77024351
82Aplasia of the phalanges of the hand (HP:0009802)1.77024351
83Aplasia involving bones of the extremities (HP:0009825)1.77024351
84Broad metatarsal (HP:0001783)1.76050419
85Uterine leiomyosarcoma (HP:0002891)1.75946558
86Leiomyosarcoma (HP:0100243)1.75946558
87Abnormality of the antihelix (HP:0009738)1.75350937
88Severe visual impairment (HP:0001141)1.75302239
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74514072
90Short 5th finger (HP:0009237)1.74029744
91High anterior hairline (HP:0009890)1.73951211
92Gastrointestinal carcinoma (HP:0002672)1.73913854
93Malignant gastrointestinal tract tumors (HP:0006749)1.73913854
94Anophthalmia (HP:0000528)1.73891830
95Abnormal lung lobation (HP:0002101)1.73885083
96Abnormality of the diencephalon (HP:0010662)1.73210434
97Transitional cell carcinoma of the bladder (HP:0006740)1.72822579
98Absent frontal sinuses (HP:0002688)1.72748361
99Abnormality of the ischium (HP:0003174)1.72729088
100Increased density of long bones (HP:0006392)1.71931897
101Atresia of the external auditory canal (HP:0000413)1.70444801
102Heterotopia (HP:0002282)1.70224660
103Calcaneovalgus deformity (HP:0001848)1.70161225
104Medulloblastoma (HP:0002885)1.69983038
105Abnormality of the labia minora (HP:0012880)1.69205732
106Vertebral arch anomaly (HP:0008438)1.69124993
107Thickened helices (HP:0000391)1.68515143
108Abnormality of the aortic arch (HP:0012303)1.68133833
109Flat cornea (HP:0007720)1.68008289
110Striae distensae (HP:0001065)1.67459412
111Hyperacusis (HP:0010780)1.67134636
112Thin ribs (HP:0000883)1.66387208
113Joint laxity (HP:0001388)1.64533913
114Vitreoretinal degeneration (HP:0000655)1.64412804
115Hypoplasia of the maxilla (HP:0000327)1.63992292
116Morphological abnormality of the middle ear (HP:0008609)1.63108401
117Shoulder girdle muscle weakness (HP:0003547)1.62721871
118Bifid tongue (HP:0010297)1.61590457
119Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61305737
120Hyperextensible skin (HP:0000974)1.61021878
121Deviation of the thumb (HP:0009603)1.60836109
122Astrocytoma (HP:0009592)1.60504683
123Abnormality of the astrocytes (HP:0100707)1.60504683
124Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.59881250
125Wide cranial sutures (HP:0010537)1.59310359
126Abnormality of the phalanges of the hallux (HP:0010057)1.58721508
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58319993
128Overgrowth (HP:0001548)1.57507910
129Aortic dissection (HP:0002647)1.57297108
130Broad toe (HP:0001837)1.56959314
131Preaxial foot polydactyly (HP:0001841)1.56726813
132Colon cancer (HP:0003003)1.56532477
133Bladder carcinoma (HP:0002862)1.56528982
134Bladder neoplasm (HP:0009725)1.56528982
135Patellar aplasia (HP:0006443)1.55744524
136Deformed tarsal bones (HP:0008119)1.55512274
137Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55159494
138Protruding ear (HP:0000411)1.54883623
139Volvulus (HP:0002580)1.54298995
140Spinal rigidity (HP:0003306)1.53842616
141Buphthalmos (HP:0000557)1.52920785
142Mitral valve prolapse (HP:0001634)1.51847091
143Broad ribs (HP:0000885)1.51805982
144Nephroblastoma (Wilms tumor) (HP:0002667)1.51770007
145Coronal craniosynostosis (HP:0004440)1.50667313
146Proximal placement of thumb (HP:0009623)1.50649053
147Vascular tortuosity (HP:0004948)1.50507814
148Abnormality of the hip-girdle musculature (HP:0001445)1.50306927
149Abnormality of the musculature of the pelvis (HP:0001469)1.50306927
150Elfin facies (HP:0004428)1.49944197
151Enlarged penis (HP:0000040)1.49907758
152Synostosis of carpal bones (HP:0005048)1.49892595
153Aplasia/Hypoplasia of the patella (HP:0006498)1.49771468
154Megalocornea (HP:0000485)1.49625586
155Bicornuate uterus (HP:0000813)1.49001095
156Embryonal renal neoplasm (HP:0011794)1.48158381
157Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.48007740
158Vertebral hypoplasia (HP:0008417)1.48007740
159Deep philtrum (HP:0002002)1.46875304
160Esophageal atresia (HP:0002032)1.46611330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.30225450
2LATS22.85186220
3BRD42.81529947
4LATS12.79791125
5DDR22.66335275
6TNIK2.66190531
7PRKD32.54122771
8CASK2.46743392
9EPHB22.39702470
10PNCK2.36990927
11PRPF4B2.27751404
12PASK2.22466554
13TAOK22.20905233
14CDC72.17006483
15PDGFRA2.16195367
16NEK22.06925984
17KSR11.91181437
18STK38L1.90714833
19MAP3K101.89549571
20STK241.87184428
21TAF11.79185192
22TRIB31.73328127
23ERBB31.73286083
24BUB11.72591926
25IRAK31.65624923
26ICK1.61805040
27SIK31.59782988
28UHMK11.57581036
29TESK11.51826278
30ACVR1B1.50682235
31NTRK11.50448177
32MKNK11.48622878
33PLK31.45845044
34STK31.40370258
35MARK11.31851639
36BCR1.30551216
37CDK71.28168247
38FGFR11.27503147
39MKNK21.23023026
40MTOR1.22655789
41BRSK11.22084917
42PLK11.21288936
43CHEK21.18182075
44RPS6KA41.17806094
45WEE11.16926316
46NTRK21.15478556
47MAP3K41.14337797
48PAK41.13555373
49MOS1.12133472
50TTK1.00997043
51PTK61.00119255
52EPHA40.97105828
53TYRO30.97005696
54CAMK1G0.95921334
55BRSK20.95556771
56ATR0.95455669
57DYRK30.93490112
58DYRK20.92867556
59WNK30.90543124
60MINK10.90158584
61PKN20.89395577
62CHEK10.87157707
63SRPK10.86825674
64CDK11A0.86706659
65PTK20.84083465
66AKT30.83032121
67PDGFRB0.81818426
68FGFR20.79549751
69PDK40.78825663
70PDK30.78825663
71TTN0.78113066
72BMX0.77665212
73ERBB40.76758771
74DMPK0.76649824
75PLK40.73457985
76ALK0.73335631
77BRAF0.71801524
78TGFBR10.71770268
79AURKB0.71736680
80NEK10.69523419
81CDK20.69390840
82TSSK60.68360273
83PAK20.67418241
84MET0.64120300
85LIMK10.63530327
86ATM0.60824978
87NTRK30.60713493
88FER0.59257604
89YES10.58721589
90CDK10.56898079
91CSNK1G20.56751956
92CDK180.56300770
93AURKA0.56215561
94PAK60.56206904
95CSNK1E0.54034856
96NEK90.53965255
97MAP3K90.52777513
98EPHA20.52505556
99WNK10.52325269
100CDK60.51974394
101CAMK1D0.50954698
102STK390.49966002
103SCYL20.49300701
104PLK20.48964107
105MELK0.48196626
106PAK30.48002137
107CDK40.47744756
108RIPK10.47177704
109EPHA30.46879932
110MAP2K70.46052540
111EIF2AK20.45504987
112CHUK0.45296121
113CDK140.44431969
114ILK0.43093813
115CDK150.42835740
116TAOK10.42764470
117CSNK1A1L0.42514151
118DYRK1B0.41845438
119FGFR40.40880385
120DAPK10.39868319
121EEF2K0.39744630
122PBK0.39613282
123MAP3K80.39412947
124PAK10.38490850
125RPS6KB10.38481984
126ROCK20.38057785
127MAPK90.37932374
128PRKCG0.37753638
129MAPK140.37590019
130CSNK1G10.37165179
131CDK90.37151759
132IRAK10.36873803
133RET0.34707740
134SGK2230.33792018
135SGK4940.33792018
136RPS6KA20.33181139
137PRKDC0.30843780
138CDK50.30823973

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.89048005
2Hedgehog signaling pathway_Homo sapiens_hsa043402.70763043
3Cell cycle_Homo sapiens_hsa041102.54815203
4Hippo signaling pathway_Homo sapiens_hsa043902.33397009
5RNA transport_Homo sapiens_hsa030132.26430151
6Steroid biosynthesis_Homo sapiens_hsa001001.97498359
7Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.92084668
8Spliceosome_Homo sapiens_hsa030401.86714287
9mRNA surveillance pathway_Homo sapiens_hsa030151.79032492
10Oocyte meiosis_Homo sapiens_hsa041141.67447067
11MicroRNAs in cancer_Homo sapiens_hsa052061.66899305
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.65892227
13Wnt signaling pathway_Homo sapiens_hsa043101.63150056
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63127013
15Adherens junction_Homo sapiens_hsa045201.56473859
16Proteoglycans in cancer_Homo sapiens_hsa052051.54109218
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51167089
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49790348
19Endometrial cancer_Homo sapiens_hsa052131.46607974
20Base excision repair_Homo sapiens_hsa034101.46034872
21Colorectal cancer_Homo sapiens_hsa052101.42414015
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41727035
23Prion diseases_Homo sapiens_hsa050201.41607980
24Small cell lung cancer_Homo sapiens_hsa052221.40714319
25TGF-beta signaling pathway_Homo sapiens_hsa043501.36774340
26p53 signaling pathway_Homo sapiens_hsa041151.35386943
27Chronic myeloid leukemia_Homo sapiens_hsa052201.30943298
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28627135
29ECM-receptor interaction_Homo sapiens_hsa045121.28595257
30DNA replication_Homo sapiens_hsa030301.26732459
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24673035
32Focal adhesion_Homo sapiens_hsa045101.23917924
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22090887
34HTLV-I infection_Homo sapiens_hsa051661.21485209
35Axon guidance_Homo sapiens_hsa043601.19987020
36mTOR signaling pathway_Homo sapiens_hsa041501.15455909
37Melanogenesis_Homo sapiens_hsa049161.14033131
38Glioma_Homo sapiens_hsa052141.11467855
39Basal transcription factors_Homo sapiens_hsa030221.10869029
40Prostate cancer_Homo sapiens_hsa052151.07669907
41Viral carcinogenesis_Homo sapiens_hsa052031.06600755
42Dorso-ventral axis formation_Homo sapiens_hsa043201.05867706
43Bladder cancer_Homo sapiens_hsa052191.05030024
44Mismatch repair_Homo sapiens_hsa034301.04337686
45Pathways in cancer_Homo sapiens_hsa052001.03412509
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03394955
47RNA polymerase_Homo sapiens_hsa030201.01955009
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98789201
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97648972
50Tight junction_Homo sapiens_hsa045300.97407461
51Fanconi anemia pathway_Homo sapiens_hsa034600.97163113
52Notch signaling pathway_Homo sapiens_hsa043300.97086381
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95175188
54Melanoma_Homo sapiens_hsa052180.93210923
55Viral myocarditis_Homo sapiens_hsa054160.92935985
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.92222865
57RNA degradation_Homo sapiens_hsa030180.89874475
58Thyroid cancer_Homo sapiens_hsa052160.88722683
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.88409407
60ErbB signaling pathway_Homo sapiens_hsa040120.87670288
61Insulin secretion_Homo sapiens_hsa049110.86813674
62Alcoholism_Homo sapiens_hsa050340.86534405
63Nucleotide excision repair_Homo sapiens_hsa034200.86345492
64Fatty acid biosynthesis_Homo sapiens_hsa000610.85718483
65Epstein-Barr virus infection_Homo sapiens_hsa051690.84689983
66N-Glycan biosynthesis_Homo sapiens_hsa005100.84689830
67Salmonella infection_Homo sapiens_hsa051320.83858719
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82841029
69Non-small cell lung cancer_Homo sapiens_hsa052230.82374648
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82341468
71One carbon pool by folate_Homo sapiens_hsa006700.82069662
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81489289
73Vitamin B6 metabolism_Homo sapiens_hsa007500.79686654
74Renal cell carcinoma_Homo sapiens_hsa052110.79360364
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79144647
76Non-homologous end-joining_Homo sapiens_hsa034500.78973625
77Estrogen signaling pathway_Homo sapiens_hsa049150.78531975
78Pancreatic cancer_Homo sapiens_hsa052120.76897779
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75437703
80Protein export_Homo sapiens_hsa030600.75432741
81Protein digestion and absorption_Homo sapiens_hsa049740.73914448
82Homologous recombination_Homo sapiens_hsa034400.73152299
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72538883
84Renin-angiotensin system_Homo sapiens_hsa046140.71557258
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70827382
86Pyrimidine metabolism_Homo sapiens_hsa002400.70201625
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69927376
88Shigellosis_Homo sapiens_hsa051310.69592329
89Hepatitis B_Homo sapiens_hsa051610.67472175
90Dilated cardiomyopathy_Homo sapiens_hsa054140.67346726
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.66411293
92Glucagon signaling pathway_Homo sapiens_hsa049220.65402016
93FoxO signaling pathway_Homo sapiens_hsa040680.65095218
94Gap junction_Homo sapiens_hsa045400.64855892
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64680311
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64654073
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63040725
98Rap1 signaling pathway_Homo sapiens_hsa040150.62534385
99MAPK signaling pathway_Homo sapiens_hsa040100.60137823
100Systemic lupus erythematosus_Homo sapiens_hsa053220.59542320
101Prolactin signaling pathway_Homo sapiens_hsa049170.59426312
102Selenocompound metabolism_Homo sapiens_hsa004500.55874663
103Ribosome_Homo sapiens_hsa030100.55183602
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54877368
105Dopaminergic synapse_Homo sapiens_hsa047280.54478474
106Type II diabetes mellitus_Homo sapiens_hsa049300.53846511
107HIF-1 signaling pathway_Homo sapiens_hsa040660.53664735
108Lysine degradation_Homo sapiens_hsa003100.53075980
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52527254
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52301602
111Insulin signaling pathway_Homo sapiens_hsa049100.51231240
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50843910
113Cocaine addiction_Homo sapiens_hsa050300.50671372
114Long-term potentiation_Homo sapiens_hsa047200.50600857
115Glutamatergic synapse_Homo sapiens_hsa047240.50123898
116Purine metabolism_Homo sapiens_hsa002300.49551520
117Amphetamine addiction_Homo sapiens_hsa050310.49468588
118Circadian entrainment_Homo sapiens_hsa047130.49379060
119VEGF signaling pathway_Homo sapiens_hsa043700.48807058
120AMPK signaling pathway_Homo sapiens_hsa041520.48766661
121Amoebiasis_Homo sapiens_hsa051460.48679238
122Folate biosynthesis_Homo sapiens_hsa007900.48666002
123Ras signaling pathway_Homo sapiens_hsa040140.46589258
124Long-term depression_Homo sapiens_hsa047300.44880411
125Biosynthesis of amino acids_Homo sapiens_hsa012300.40997122
126Thyroid hormone synthesis_Homo sapiens_hsa049180.39694062
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38748077
128Vibrio cholerae infection_Homo sapiens_hsa051100.36826186
129PPAR signaling pathway_Homo sapiens_hsa033200.34228540
130Choline metabolism in cancer_Homo sapiens_hsa052310.32977885

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