UBTF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.21084993
2protein localization to kinetochore (GO:0034501)4.82434906
3negative regulation of erythrocyte differentiation (GO:0045647)4.81018190
4nuclear pore organization (GO:0006999)4.61770388
5nuclear pore complex assembly (GO:0051292)4.48986794
6heterochromatin organization (GO:0070828)4.25984488
7pre-miRNA processing (GO:0031054)4.19419154
8regulation of translational termination (GO:0006449)4.14871721
9folic acid-containing compound biosynthetic process (GO:0009396)3.99842248
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.94376652
11regulation of translational fidelity (GO:0006450)3.93513197
12negative regulation of histone methylation (GO:0031061)3.86329360
13protein localization to chromosome, centromeric region (GO:0071459)3.85964083
14mitotic nuclear envelope disassembly (GO:0007077)3.85130167
15chromatin assembly (GO:0031497)3.83737823
16DNA replication-dependent nucleosome organization (GO:0034723)3.80179090
17DNA replication-dependent nucleosome assembly (GO:0006335)3.80179090
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.78924959
19regulation of histone H3-K27 methylation (GO:0061085)3.78534356
20DNA duplex unwinding (GO:0032508)3.77846333
21DNA geometric change (GO:0032392)3.73255260
22regulation of RNA export from nucleus (GO:0046831)3.70871137
23sister chromatid segregation (GO:0000819)3.65675125
24nuclear envelope disassembly (GO:0051081)3.63672789
25membrane disassembly (GO:0030397)3.63672789
26mitotic sister chromatid segregation (GO:0000070)3.61847947
27histone H3-K36 demethylation (GO:0070544)3.60904081
28regulation of histone H3-K9 methylation (GO:0051570)3.59007311
29regulation of posttranscriptional gene silencing (GO:0060147)3.56663268
30regulation of gene silencing by miRNA (GO:0060964)3.56663268
31regulation of gene silencing by RNA (GO:0060966)3.56663268
32DNA replication initiation (GO:0006270)3.55335727
33mitotic chromosome condensation (GO:0007076)3.54723260
34IMP biosynthetic process (GO:0006188)3.48211954
35peptidyl-lysine dimethylation (GO:0018027)3.46784234
36negative regulation of mRNA processing (GO:0050686)3.45814945
37negative regulation of RNA splicing (GO:0033119)3.45686148
38pore complex assembly (GO:0046931)3.45521315
39positive regulation of chromosome segregation (GO:0051984)3.44588220
40dosage compensation (GO:0007549)3.43765944
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.41903904
42formation of translation preinitiation complex (GO:0001731)3.38811213
43RNA stabilization (GO:0043489)3.38014909
44mRNA stabilization (GO:0048255)3.38014909
45regulation of NFAT protein import into nucleus (GO:0051532)3.37387935
46thymic T cell selection (GO:0045061)3.34992547
47spliceosomal tri-snRNP complex assembly (GO:0000244)3.33923138
48regulation of chromatin binding (GO:0035561)3.33306029
49regulation of spindle organization (GO:0090224)3.32567426
50DNA topological change (GO:0006265)3.31589054
51negative regulation of mRNA metabolic process (GO:1903312)3.29274697
52nucleosome disassembly (GO:0006337)3.27364622
53alternative mRNA splicing, via spliceosome (GO:0000380)3.26255067
54mitotic G1 DNA damage checkpoint (GO:0031571)3.24928245
55adherens junction assembly (GO:0034333)3.24299764
56DNA strand elongation involved in DNA replication (GO:0006271)3.23950475
57positive thymic T cell selection (GO:0045059)3.22441715
58nucleobase biosynthetic process (GO:0046112)3.20956639
59maturation of SSU-rRNA (GO:0030490)3.20550489
60regulation of glucose import in response to insulin stimulus (GO:2001273)3.19292295
61peptidyl-arginine omega-N-methylation (GO:0035247)3.14549886
62focal adhesion assembly (GO:0048041)3.13779445
63cell-substrate adherens junction assembly (GO:0007045)3.13779445
64regulation of sister chromatid cohesion (GO:0007063)3.12996863
65regulation of mitotic spindle organization (GO:0060236)3.12555468
66cellular response to epidermal growth factor stimulus (GO:0071364)3.10002847
67nuclear envelope organization (GO:0006998)3.08558001
68protein localization to chromosome (GO:0034502)3.07440908
69viral transcription (GO:0019083)3.07073239
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.05975667
71histone H2A monoubiquitination (GO:0035518)3.04419141
72DNA strand elongation (GO:0022616)3.02091626
73chromatin assembly or disassembly (GO:0006333)3.01126139
74regulation of nucleobase-containing compound transport (GO:0032239)3.01073798
75embryonic process involved in female pregnancy (GO:0060136)2.99642383
76translational termination (GO:0006415)2.99220252
77regulation of hippo signaling (GO:0035330)2.98452584
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98082230
79apoptotic process involved in morphogenesis (GO:0060561)2.97459864
80mitotic metaphase plate congression (GO:0007080)2.97310121
81histone H4-K12 acetylation (GO:0043983)2.96956865
82trophectodermal cell differentiation (GO:0001829)2.95721120
83DNA replication checkpoint (GO:0000076)2.95297609
84protein localization to endosome (GO:0036010)2.95278545
85mitotic sister chromatid cohesion (GO:0007064)2.95023052
86translational initiation (GO:0006413)2.94511504
87ribosome biogenesis (GO:0042254)2.93577144
88negative regulation of cell size (GO:0045792)2.92244391
89regulation of helicase activity (GO:0051095)2.90577145
90positive regulation of gamma-delta T cell activation (GO:0046645)2.90380096
91DNA conformation change (GO:0071103)2.89714508
92establishment of apical/basal cell polarity (GO:0035089)2.88838237
93ribosome assembly (GO:0042255)2.88151503
94positive regulation of SMAD protein import into nucleus (GO:0060391)2.87847870
95RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.86901488
96mRNA splicing, via spliceosome (GO:0000398)2.86901488
97IMP metabolic process (GO:0046040)2.86788919
983-UTR-mediated mRNA stabilization (GO:0070935)2.86785482
99RNA splicing, via transesterification reactions (GO:0000375)2.83463309
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83176832
101peptidyl-arginine methylation (GO:0018216)2.80653493
102peptidyl-arginine N-methylation (GO:0035246)2.80653493
103mitotic G1/S transition checkpoint (GO:0044819)2.80132212
104cellular hyperosmotic response (GO:0071474)2.78651482
105planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78467203
106intracellular estrogen receptor signaling pathway (GO:0030520)2.78078746
107mannose metabolic process (GO:0006013)2.77165829
108cellular protein complex localization (GO:0034629)2.77134966
109maternal placenta development (GO:0001893)2.76597074
110G1 DNA damage checkpoint (GO:0044783)2.76496644
111modulation by virus of host process (GO:0019054)2.76451959
112response to epidermal growth factor (GO:0070849)2.75854032
113translesion synthesis (GO:0019985)2.74711470
114translational elongation (GO:0006414)2.74702389
115regulation of RNA stability (GO:0043487)2.73982789
116histone H4-K5 acetylation (GO:0043981)2.72916972
117histone H4-K8 acetylation (GO:0043982)2.72916972
118spindle assembly involved in mitosis (GO:0090307)2.72385537
119activation of Rac GTPase activity (GO:0032863)2.71676921
120protein complex localization (GO:0031503)2.71364793
121protein export from nucleus (GO:0006611)2.71244606
122glucocorticoid receptor signaling pathway (GO:0042921)2.70373987
123mRNA transport (GO:0051028)2.70170412
124response to laminar fluid shear stress (GO:0034616)2.69441401
125corticosteroid receptor signaling pathway (GO:0031958)2.69395474
126regulation of mRNA stability (GO:0043488)2.68774891
127modulation by symbiont of host cellular process (GO:0044068)2.68768101
128regulation of chromosome segregation (GO:0051983)2.68758858
129positive regulation of RNA splicing (GO:0033120)2.68531270
130regulation of DNA damage checkpoint (GO:2000001)2.66555493
131histone lysine demethylation (GO:0070076)2.65442936
132ribonucleoprotein complex biogenesis (GO:0022613)2.64942301
133determination of adult lifespan (GO:0008340)2.64563635
134regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64311736
135pentose-phosphate shunt (GO:0006098)2.64223526
136T cell selection (GO:0045058)2.63605758
137ribosomal large subunit biogenesis (GO:0042273)2.63545514
138protein-DNA complex disassembly (GO:0032986)2.62840239
139epithelial cell differentiation involved in prostate gland development (GO:0060742)2.59649754
140regulation of gamma-delta T cell differentiation (GO:0045586)2.59348658
141positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58936348
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.56911068
143negative thymic T cell selection (GO:0045060)2.55142410
144V(D)J recombination (GO:0033151)2.54920401
145histone H3-K9 demethylation (GO:0033169)2.53466408
146COPI coating of Golgi vesicle (GO:0048205)2.52859795
147Golgi transport vesicle coating (GO:0048200)2.52859795
148regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51495804
149histone demethylation (GO:0016577)2.50301512
150positive T cell selection (GO:0043368)2.48841750
151cellular response to interleukin-4 (GO:0071353)2.48716875
152B cell receptor signaling pathway (GO:0050853)2.48275992
153positive regulation of Cdc42 GTPase activity (GO:0043089)2.45873951
154negative regulation of histone modification (GO:0031057)2.44442242
155negative regulation of myotube differentiation (GO:0010832)2.44176212
156proline biosynthetic process (GO:0006561)2.44048658
157cellular response to virus (GO:0098586)2.41844141
158positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.38914443
159regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.38914443
160regulation of histone methylation (GO:0031060)2.38725834
161stress fiber assembly (GO:0043149)2.37551114
162regulation of ARF protein signal transduction (GO:0032012)2.36602004
163antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.34920387
164barbed-end actin filament capping (GO:0051016)2.34744254
165megakaryocyte development (GO:0035855)2.34369609
166negative regulation of striated muscle cell differentiation (GO:0051154)2.33997715
167Peyers patch development (GO:0048541)2.33070146
168mucosal-associated lymphoid tissue development (GO:0048537)2.33070146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.36268393
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.99708107
3* MYC_22102868_ChIP-Seq_BL_Human3.22573212
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.17306103
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07501341
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.06249794
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03223681
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79520545
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62633381
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28142258
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16601974
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04856494
13* VDR_21846776_ChIP-Seq_THP-1_Human2.00859416
14ZNF263_19887448_ChIP-Seq_K562_Human1.94663289
15CIITA_25753668_ChIP-Seq_RAJI_Human1.89924636
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87403855
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85008087
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.83729144
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83490226
20XRN2_22483619_ChIP-Seq_HELA_Human1.83083753
21AR_21909140_ChIP-Seq_LNCAP_Human1.78830394
22* VDR_24763502_ChIP-Seq_THP-1_Human1.74235329
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72763992
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72561967
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69677971
26TCF7_22412390_ChIP-Seq_EML_Mouse1.69631222
27* KDM2B_26808549_Chip-Seq_DND41_Human1.64910171
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62384694
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58808998
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58808998
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58808998
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58209102
33KDM2B_26808549_Chip-Seq_K562_Human1.56488906
34* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53763686
35* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52880625
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52141498
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50742360
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49945834
39KDM5A_27292631_Chip-Seq_BREAST_Human1.49849524
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47046991
41* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46692741
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.45467029
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44873698
44* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44396033
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.43766251
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43516017
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43337666
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.40849443
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40461412
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39938886
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38178765
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36695147
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36585809
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36077568
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34381317
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33901090
57* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31842288
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31748529
59* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30693735
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.30262193
61* UTX_26944678_Chip-Seq_JUKART_Human1.28166625
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27578649
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27472090
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26992566
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26299347
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26055564
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24336496
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23296381
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.22413542
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22333958
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21852511
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21800855
73P68_20966046_ChIP-Seq_HELA_Human1.20383072
74* MAF_26560356_Chip-Seq_TH1_Human1.19717396
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.19485047
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18024041
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.17832808
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17752428
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17515976
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17264046
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17041093
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16993429
83ATF3_27146783_Chip-Seq_COLON_Human1.16419321
84NCOR1_26117541_ChIP-Seq_K562_Human1.16383881
85TTF2_22483619_ChIP-Seq_HELA_Human1.16235229
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15043926
87SCL_19346495_ChIP-Seq_HPC-7_Human1.14457222
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14291959
89* CREB1_26743006_Chip-Seq_LNCaP_Human1.14259040
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12885110
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12658247
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12531287
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12231338
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12201840
95* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11838697
96GABP_19822575_ChIP-Seq_HepG2_Human1.10257580
97SMC4_20622854_ChIP-Seq_HELA_Human1.08995335
98CHD1_26751641_Chip-Seq_LNCaP_Human1.08634647
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07767760
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07595215
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07137867
102FOXP3_21729870_ChIP-Seq_TREG_Human1.06527857
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06298609
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06085735
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05144197
106MYB_26560356_Chip-Seq_TH1_Human1.04998581
107YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04255253
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04119519
109* KDM2B_26808549_Chip-Seq_JURKAT_Human1.03954083
110* RACK7_27058665_Chip-Seq_MCF-7_Human1.03843473
111TP63_17297297_ChIP-ChIP_HaCaT_Human1.03758798
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02940330
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02579320
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02486603
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02296797
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02242727
117VDR_23849224_ChIP-Seq_CD4+_Human1.01493819
118* LXR_22292898_ChIP-Seq_THP-1_Human1.00917519
119EST1_17652178_ChIP-ChIP_JURKAT_Human1.00791196
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00017718
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99983019
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.99913449
123CLOCK_20551151_ChIP-Seq_293T_Human0.99902395
124TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99591739
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99493745
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99196862
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.98972059
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98783921
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98542871
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.98531360
131FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98141042
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97173758
133NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97165206
134THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96867968
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95950543
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94221094
137SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93133601
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92453408
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92441393
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92222982
141MAF_26560356_Chip-Seq_TH2_Human0.92111178
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92093126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.95600654
2MP0004957_abnormal_blastocyst_morpholog3.59146091
3MP0003693_abnormal_embryo_hatching3.56246765
4MP0010094_abnormal_chromosome_stability3.32173194
5MP0003705_abnormal_hypodermis_morpholog3.21161247
6MP0003077_abnormal_cell_cycle3.10402373
7MP0005076_abnormal_cell_differentiation2.85811113
8MP0010352_gastrointestinal_tract_polyps2.83893670
9MP0008057_abnormal_DNA_replication2.73664131
10MP0001730_embryonic_growth_arrest2.60376350
11MP0005451_abnormal_body_composition2.43089214
12MP0000350_abnormal_cell_proliferation2.35249182
13MP0003123_paternal_imprinting2.30176625
14MP0000537_abnormal_urethra_morphology2.26090099
15MP0002009_preneoplasia2.23899771
16MP0010307_abnormal_tumor_latency2.20344949
17MP0002396_abnormal_hematopoietic_system2.05334483
18MP0001672_abnormal_embryogenesis/_devel2.01136077
19MP0005380_embryogenesis_phenotype2.01136077
20MP0009278_abnormal_bone_marrow1.98274963
21MP0002084_abnormal_developmental_patter1.95812179
22MP0005409_darkened_coat_color1.90779121
23MP0002086_abnormal_extraembryonic_tissu1.90738073
24MP0002085_abnormal_embryonic_tissue1.90524698
25MP0004197_abnormal_fetal_growth/weight/1.90080329
26MP0001697_abnormal_embryo_size1.87481136
27MP0003984_embryonic_growth_retardation1.87094538
28MP0002088_abnormal_embryonic_growth/wei1.85622811
29MP0008007_abnormal_cellular_replicative1.78680001
30MP0002080_prenatal_lethality1.75438368
31MP0008260_abnormal_autophagy1.71065630
32MP0003566_abnormal_cell_adhesion1.70251564
33MP0010234_abnormal_vibrissa_follicle1.69413985
34MP0001849_ear_inflammation1.67769636
35MP0003091_abnormal_cell_migration1.64979305
36MP0004808_abnormal_hematopoietic_stem1.64542194
37MP0004185_abnormal_adipocyte_glucose1.62410337
38MP0003300_gastrointestinal_ulcer1.57369669
39MP0008932_abnormal_embryonic_tissue1.56796759
40MP0003567_abnormal_fetal_cardiomyocyte1.51937143
41MP0003436_decreased_susceptibility_to1.45849382
42MP0008058_abnormal_DNA_repair1.43108706
43MP0003119_abnormal_digestive_system1.41587973
44MP0000490_abnormal_crypts_of1.39331408
45MP0000733_abnormal_muscle_development1.36819568
46MP0000428_abnormal_craniofacial_morphol1.34837065
47MP0004381_abnormal_hair_follicle1.33247027
48MP0002166_altered_tumor_susceptibility1.32541833
49MP0000703_abnormal_thymus_morphology1.29444581
50MP0004947_skin_inflammation1.28762808
51MP0001348_abnormal_lacrimal_gland1.28043132
52MP0003121_genomic_imprinting1.27530825
53MP0005058_abnormal_lysosome_morphology1.27210613
54MP0004858_abnormal_nervous_system1.26489188
55MP0008877_abnormal_DNA_methylation1.25332906
56MP0000858_altered_metastatic_potential1.23224262
57MP0003786_premature_aging1.21141295
58MP0002019_abnormal_tumor_incidence1.20837392
59MP0000313_abnormal_cell_death1.20334495
60MP0009672_abnormal_birth_weight1.19738377
61MP0003303_peritoneal_inflammation1.19683996
62MP0000685_abnormal_immune_system1.18310306
63MP0001873_stomach_inflammation1.14741631
64MP0008438_abnormal_cutaneous_collagen1.14352081
65MP0005623_abnormal_meninges_morphology1.14303620
66MP0009053_abnormal_anal_canal1.13806975
67MP0003763_abnormal_thymus_physiology1.13107745
68MP0010030_abnormal_orbit_morphology1.12756559
69MP0003172_abnormal_lysosome_physiology1.12596692
70MP0003283_abnormal_digestive_organ1.11559228
71MP0005397_hematopoietic_system_phenotyp1.11387435
72MP0001545_abnormal_hematopoietic_system1.11387435
73MP0005377_hearing/vestibular/ear_phenot1.10625645
74MP0003878_abnormal_ear_physiology1.10625645
75MP0000678_abnormal_parathyroid_gland1.10591057
76MP0003115_abnormal_respiratory_system1.10393070
77MP0002092_abnormal_eye_morphology1.10025832
78MP0009703_decreased_birth_body1.08867943
79MP0001293_anophthalmia1.08651659
80MP0002089_abnormal_postnatal_growth/wei1.08235608
81MP0003890_abnormal_embryonic-extraembry1.05609550
82MP0004233_abnormal_muscle_weight1.04108822
83MP0002249_abnormal_larynx_morphology1.00994629
84MP0002925_abnormal_cardiovascular_devel1.00695472
85MP0002111_abnormal_tail_morphology1.00591974
86MP0002429_abnormal_blood_cell1.00335133
87MP0005023_abnormal_wound_healing0.98449992
88MP0002060_abnormal_skin_morphology0.97792227
89MP0003935_abnormal_craniofacial_develop0.97345749
90MP0008770_decreased_survivor_rate0.95635776
91MP0008961_abnormal_basal_metabolism0.95272808
92MP0000716_abnormal_immune_system0.95198341
93MP0005501_abnormal_skin_physiology0.95097849
94MP0002877_abnormal_melanocyte_morpholog0.95012837
95MP0001915_intracranial_hemorrhage0.93688444
96MP0002697_abnormal_eye_size0.93666871
97MP0009931_abnormal_skin_appearance0.93216398
98MP0003191_abnormal_cellular_cholesterol0.92383094
99MP0001800_abnormal_humoral_immune0.92125065
100MP0000477_abnormal_intestine_morphology0.91178886
101MP0002398_abnormal_bone_marrow0.91085053
102MP0000747_muscle_weakness0.89927773
103MP0002420_abnormal_adaptive_immunity0.89630335
104MP0002722_abnormal_immune_system0.87640138
105MP0001819_abnormal_immune_cell0.87557427
106MP0003861_abnormal_nervous_system0.83845488
107MP0004264_abnormal_extraembryonic_tissu0.83047598
108MP0000003_abnormal_adipose_tissue0.82983854
109MP0002653_abnormal_ependyma_morphology0.82532766
110MP0005666_abnormal_adipose_tissue0.82058823
111MP0003656_abnormal_erythrocyte_physiolo0.81706075
112MP0005621_abnormal_cell_physiology0.81357185
113MP0003937_abnormal_limbs/digits/tail_de0.81065438
114MP0000432_abnormal_head_morphology0.78949295
115MP0000759_abnormal_skeletal_muscle0.78861983
116MP0001835_abnormal_antigen_presentation0.78149027
117MP0009333_abnormal_splenocyte_physiolog0.78046538
118MP0004087_abnormal_muscle_fiber0.77617834
119MP0001784_abnormal_fluid_regulation0.77380010
120MP0003453_abnormal_keratinocyte_physiol0.77157571
121MP0003866_abnormal_defecation0.77020065
122MP0002405_respiratory_system_inflammati0.76852462
123MP0005000_abnormal_immune_tolerance0.76512952
124MP0010630_abnormal_cardiac_muscle0.76434082
125MP0000266_abnormal_heart_morphology0.76065783
126MP0008995_early_reproductive_senescence0.74019467
127MP0005384_cellular_phenotype0.72484560
128MP0006054_spinal_hemorrhage0.70934591
129MP0000689_abnormal_spleen_morphology0.70920798
130MP0003221_abnormal_cardiomyocyte_apopto0.70865657
131MP0001145_abnormal_male_reproductive0.69261805
132MP0002796_impaired_skin_barrier0.68750992
133MP0000377_abnormal_hair_follicle0.67754752
134MP0003787_abnormal_imprinting0.65911185
135MP0002210_abnormal_sex_determination0.64761721
136MP0000467_abnormal_esophagus_morphology0.64442619
137MP0005375_adipose_tissue_phenotype0.63772968

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.13842175
2Hyperacusis (HP:0010780)3.15454771
3Astrocytoma (HP:0009592)3.13281812
4Abnormality of the astrocytes (HP:0100707)3.13281812
5Selective tooth agenesis (HP:0001592)3.10579529
6Cerebral aneurysm (HP:0004944)2.91608710
7Asymmetry of the thorax (HP:0001555)2.80805119
8Increased nuchal translucency (HP:0010880)2.78212475
9Proximal placement of thumb (HP:0009623)2.75912251
10Obstructive sleep apnea (HP:0002870)2.67600768
11Medulloblastoma (HP:0002885)2.65530144
12Volvulus (HP:0002580)2.65365874
13Broad face (HP:0000283)2.64466387
14Cellulitis (HP:0100658)2.64028373
15Basal cell carcinoma (HP:0002671)2.62412149
16Deviation of the thumb (HP:0009603)2.61480332
17Colon cancer (HP:0003003)2.59289573
18Shallow orbits (HP:0000586)2.51783107
19Ankle contracture (HP:0006466)2.45365596
20Centrally nucleated skeletal muscle fibers (HP:0003687)2.43106353
21Pseudobulbar signs (HP:0002200)2.41210664
22Abnormality of the lower motor neuron (HP:0002366)2.41013495
23Glioma (HP:0009733)2.39134846
24Dysmetric saccades (HP:0000641)2.36519977
25Renal duplication (HP:0000075)2.35969906
26Rectal prolapse (HP:0002035)2.35725396
27Insomnia (HP:0100785)2.35472696
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32340762
29Short 4th metacarpal (HP:0010044)2.32340762
30Ulnar bowing (HP:0003031)2.29327353
31Neoplasm of the oral cavity (HP:0100649)2.27868435
32Distal lower limb amyotrophy (HP:0008944)2.25782585
33Abnormality of the labia minora (HP:0012880)2.25081715
34Prominent nose (HP:0000448)2.24629420
35Neoplasm of striated muscle (HP:0009728)2.22860232
36Colitis (HP:0002583)2.21640725
37Eczematoid dermatitis (HP:0000976)2.20898448
38Genu recurvatum (HP:0002816)2.20078580
39Rhabdomyosarcoma (HP:0002859)2.20013324
40Ankyloglossia (HP:0010296)2.19887485
41High pitched voice (HP:0001620)2.19703670
42Renovascular hypertension (HP:0100817)2.18020041
43Reticulocytopenia (HP:0001896)2.17708490
44Multiple enchondromatosis (HP:0005701)2.17708290
45Overriding aorta (HP:0002623)2.17344065
46Pelvic girdle muscle weakness (HP:0003749)2.16069083
47Elfin facies (HP:0004428)2.14476609
48Disproportionate tall stature (HP:0001519)2.10708591
49Long palpebral fissure (HP:0000637)2.10599282
50Spinal cord lesions (HP:0100561)2.10529780
51Syringomyelia (HP:0003396)2.10529780
52Patellar aplasia (HP:0006443)2.09506248
53Abnormal number of incisors (HP:0011064)2.08959261
54Gastrointestinal carcinoma (HP:0002672)2.07930901
55Malignant gastrointestinal tract tumors (HP:0006749)2.07930901
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.05312100
57Deep palmar crease (HP:0006191)2.05186967
58Atresia of the external auditory canal (HP:0000413)2.04966135
59Breast hypoplasia (HP:0003187)2.04301042
60Thin bony cortex (HP:0002753)2.03744186
61Abnormality of the thoracic spine (HP:0100711)2.03531061
62Angiofibromas (HP:0010615)2.01728363
63Adenoma sebaceum (HP:0009720)2.01728363
64Pointed chin (HP:0000307)2.00347156
65Aplasia/Hypoplasia of the patella (HP:0006498)2.00328713
66Missing ribs (HP:0000921)1.98670387
67Hand muscle atrophy (HP:0009130)1.97901289
68Abnormality of the fingertips (HP:0001211)1.97869986
69Trismus (HP:0000211)1.94895081
70Biliary tract neoplasm (HP:0100574)1.94081954
71Abnormality of oral frenula (HP:0000190)1.94056425
72Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93835825
73Protrusio acetabuli (HP:0003179)1.93277078
74Bowel diverticulosis (HP:0005222)1.91865418
75Neoplasm of the pancreas (HP:0002894)1.90716116
76Biconcave vertebral bodies (HP:0004586)1.90114409
77Progressive muscle weakness (HP:0003323)1.89956281
78Dislocated radial head (HP:0003083)1.89343163
79Gastrointestinal inflammation (HP:0004386)1.87654935
80Cafe-au-lait spot (HP:0000957)1.87358123
81Increased IgE level (HP:0003212)1.86499119
82Germ cell neoplasia (HP:0100728)1.86323361
83Distal upper limb amyotrophy (HP:0007149)1.85945470
84Upper limb amyotrophy (HP:0009129)1.85945470
85Patellar dislocation (HP:0002999)1.85704905
86Fibrous tissue neoplasm (HP:0012316)1.85418560
87Fibroma (HP:0010614)1.84954581
88Skin tags (HP:0010609)1.84620849
89Flat acetabular roof (HP:0003180)1.83527596
90Long eyelashes (HP:0000527)1.83296439
91Recurrent viral infections (HP:0004429)1.82400419
92Annular pancreas (HP:0001734)1.82251804
93Heterotopia (HP:0002282)1.82094674
94Thoracic kyphosis (HP:0002942)1.81993951
95Abnormality of cells of the erythroid lineage (HP:0012130)1.81978584
96Turricephaly (HP:0000262)1.81963174
97Urethral obstruction (HP:0000796)1.81930330
98Premature rupture of membranes (HP:0001788)1.81435992
99Vertebral clefting (HP:0008428)1.79236206
100Abnormality of the 4th metacarpal (HP:0010012)1.79164667
101Sparse lateral eyebrow (HP:0005338)1.77452355
102Viral hepatitis (HP:0006562)1.77005647
103Abnormality of skeletal muscle fiber size (HP:0012084)1.76647506
104Progressive external ophthalmoplegia (HP:0000590)1.76057636
105Gastrointestinal stroma tumor (HP:0100723)1.75793474
106Short 1st metacarpal (HP:0010034)1.75347245
107Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75347245
108Metaphyseal cupping (HP:0003021)1.74889518
109Vertebral compression fractures (HP:0002953)1.74858169
110Increased variability in muscle fiber diameter (HP:0003557)1.74654976
111Persistence of primary teeth (HP:0006335)1.74390374
112Abnormality of the radial head (HP:0003995)1.74276936
113Shoulder girdle muscle weakness (HP:0003547)1.74075537
114Increased connective tissue (HP:0009025)1.73056430
115Slow saccadic eye movements (HP:0000514)1.72234753
116Lower limb amyotrophy (HP:0007210)1.71565422
117Supernumerary ribs (HP:0005815)1.71463236
118Short phalanx of the thumb (HP:0009660)1.70132205
119Abnormality of the calcaneus (HP:0008364)1.69989365
120Cutis marmorata (HP:0000965)1.69583566
121Broad palm (HP:0001169)1.69503162
122Abnormality of the hip-girdle musculature (HP:0001445)1.69331994
123Abnormality of the musculature of the pelvis (HP:0001469)1.69331994
124Dilatation of the ascending aorta (HP:0005111)1.69204933
125Achilles tendon contracture (HP:0001771)1.69187481
126Abnormality of the peritoneum (HP:0002585)1.68676070
127Absent radius (HP:0003974)1.68615131
128Birth length less than 3rd percentile (HP:0003561)1.68402755
129Facial hemangioma (HP:0000329)1.68040165
130Flat cornea (HP:0007720)1.67928162
131Reticulocytosis (HP:0001923)1.67870041
132Abnormality of the Achilles tendon (HP:0005109)1.67686085
133Blepharitis (HP:0000498)1.66929767
134Agammaglobulinemia (HP:0004432)1.66676702
135Sandal gap (HP:0001852)1.66477033
136Preauricular skin tag (HP:0000384)1.66300895
137Squamous cell carcinoma (HP:0002860)1.65952744
138Polygenic inheritance (HP:0010982)1.65798462
139Vertebral arch anomaly (HP:0008438)1.65692439
140Mitral regurgitation (HP:0001653)1.65309802
141Impulsivity (HP:0100710)1.65181845
142Increased density of long bones (HP:0006392)1.64532030
143Thin ribs (HP:0000883)1.64215566
144Bladder diverticulum (HP:0000015)1.64194564
145Chromsome breakage (HP:0040012)1.64192622
146Subacute progressive viral hepatitis (HP:0006572)1.63950580
147Arnold-Chiari malformation (HP:0002308)1.63945479
148Back pain (HP:0003418)1.63202184
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.62550555
150Osteolytic defects of the hand bones (HP:0009699)1.62550555
151Esophageal atresia (HP:0002032)1.62470182
152Distal lower limb muscle weakness (HP:0009053)1.62251399
153Premature ovarian failure (HP:0008209)1.62069797
154Absent thumb (HP:0009777)1.60771548
155Mitral valve prolapse (HP:0001634)1.60618019
156High anterior hairline (HP:0009890)1.60215318
157Segmental peripheral demyelination/remyelination (HP:0003481)1.58990222
158Abnormality of the phalanges of the hallux (HP:0010057)1.58755677
159Insidious onset (HP:0003587)1.57829938
160Termporal pattern (HP:0011008)1.57829938
161Fatigue (HP:0012378)1.56790364
162Abnormality of the columella (HP:0009929)1.56240792
163Emphysema (HP:0002097)1.55963071
164Precocious puberty (HP:0000826)1.54772500
165Broad distal phalanx of finger (HP:0009836)1.54132937
166Macroorchidism (HP:0000053)1.53048049
167Bowel incontinence (HP:0002607)1.51796463
168Flared metaphyses (HP:0003015)1.51575718
169Inflammation of the large intestine (HP:0002037)1.51409962
170Hypercortisolism (HP:0001578)1.51404649
171Spina bifida occulta (HP:0003298)1.50932521
172Aneurysm (HP:0002617)1.48711370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.12440672
2SMG13.92966336
3TRIB33.84418971
4CDK123.79380638
5EEF2K3.72955264
6MAP3K103.51845548
7PKN23.46484159
8CDC73.11477777
9NEK22.84533814
10WEE12.16063795
11ALK1.99874606
12RPS6KB21.90692908
13BUB11.88863203
14ICK1.72097202
15TTK1.71584366
16STK101.69642500
17TSSK61.63951132
18PTK61.50220349
19NEK11.48744717
20MAP4K11.47694806
21RIPK41.47521069
22CDK71.47355035
23MAP3K131.43935805
24SCYL21.40825430
25LRRK21.39022675
26* CDK41.36320998
27MAP3K81.36073892
28PAK41.33882446
29PASK1.32083676
30PDGFRA1.31592632
31MTOR1.30198639
32MAP2K31.27106633
33PLK11.24080259
34EPHA21.23457494
35CHEK11.21402706
36TYRO31.21064075
37SIK21.20820901
38GRK61.15368363
39TLK11.13942002
40RIPK11.13766494
41RPS6KA41.13390819
42ATR1.12421643
43TESK21.11246109
44TTN1.09922104
45CDK61.08446017
46AURKB1.08008983
47MARK21.06262306
48DMPK1.03589719
49STK31.03580727
50DYRK31.00754891
51PAK21.00647232
52KSR20.98883627
53BRD40.96883256
54IRAK30.95660557
55* CDK20.94467094
56BMX0.94455110
57SRPK10.94383832
58CHEK20.92004062
59MAP3K140.91781128
60CDC42BPA0.91524713
61PIM10.87086882
62LATS10.85447892
63MKNK20.85095861
64TAOK10.83854271
65STK40.82027965
66TAOK20.80475402
67FGFR30.80150741
68MKNK10.75060581
69ATM0.74115403
70LATS20.74077500
71ILK0.71720603
72DDR20.70657362
73BRSK10.70595973
74MAP3K70.69978388
75AURKA0.69736762
76FES0.69438199
77SIK10.68380105
78TYK20.68056735
79PRKD20.67923628
80MAP3K10.67294946
81CSNK1E0.65755396
82TGFBR10.65538574
83PLK30.64548928
84BTK0.64337264
85RAF10.64183368
86FLT30.61914305
87IRAK40.61382214
88EPHB10.61318577
89BRSK20.61300686
90RET0.60780145
91ZAP700.60416678
92RPS6KA20.60072275
93CDK10.59554895
94SIK30.57887963
95CAMKK10.57730989
96PDPK10.56704754
97PAK10.56163725
98PNCK0.55746224
99CAMK1G0.55701983
100FGFR10.55355761
101NTRK10.54849561
102MAPK120.54662313
103MELK0.54072547
104PRKD30.53253335
105PRKCI0.52816695
106PDGFRB0.52727856
107AKT20.52391577
108PRKDC0.51833272
109CSNK1D0.51250882
110MAP3K110.50310651
111JAK10.49947045
112MAPK110.49669125
113CSNK2A20.47800374
114JAK30.47748346
115CSF1R0.46929224
116MAPK100.44082640
117CDK90.43813347
118BLK0.42852890
119ERN10.42201561
120HCK0.41938841
121RPS6KA10.41776661
122RPS6KA60.41767706
123* MAPK140.40799075
124NME20.40403866
125CAMK1D0.39954255
126MAP3K30.39512093
127HIPK20.38436741
128IRAK20.37833066
129CLK10.35574027
130MARK30.35489491
131TBK10.35476013
132PDK10.35130073
133SGK30.34517944
134FGFR40.34312936
135RPS6KC10.33484288
136RPS6KL10.33484288
137* MAPK10.32472816
138MAPKAPK30.32461937
139* GSK3B0.32400132
140YES10.32317923
141CSK0.32101081
142PAK60.29352758

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.52847907
2Mismatch repair_Homo sapiens_hsa034303.03849175
3Spliceosome_Homo sapiens_hsa030403.00143128
4RNA transport_Homo sapiens_hsa030132.92686777
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85919236
6Cell cycle_Homo sapiens_hsa041102.43577586
7One carbon pool by folate_Homo sapiens_hsa006702.33282348
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22732516
9mRNA surveillance pathway_Homo sapiens_hsa030152.22492010
10Base excision repair_Homo sapiens_hsa034102.09939096
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95188927
12Ribosome_Homo sapiens_hsa030101.70620774
13Nucleotide excision repair_Homo sapiens_hsa034201.62948044
14Chronic myeloid leukemia_Homo sapiens_hsa052201.59750896
15Homologous recombination_Homo sapiens_hsa034401.53816571
16mTOR signaling pathway_Homo sapiens_hsa041501.47438801
17MicroRNAs in cancer_Homo sapiens_hsa052061.46051788
18Small cell lung cancer_Homo sapiens_hsa052221.45721791
19Viral carcinogenesis_Homo sapiens_hsa052031.41558207
20Notch signaling pathway_Homo sapiens_hsa043301.39977280
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33189258
22Systemic lupus erythematosus_Homo sapiens_hsa053221.33184473
23p53 signaling pathway_Homo sapiens_hsa041151.28440253
24Colorectal cancer_Homo sapiens_hsa052101.26588207
25Non-small cell lung cancer_Homo sapiens_hsa052231.25664896
26Hippo signaling pathway_Homo sapiens_hsa043901.23319345
27HTLV-I infection_Homo sapiens_hsa051661.22977368
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21600687
29Lysine degradation_Homo sapiens_hsa003101.21589244
30Endometrial cancer_Homo sapiens_hsa052131.20793603
31Antigen processing and presentation_Homo sapiens_hsa046121.20432815
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20021980
33RNA polymerase_Homo sapiens_hsa030201.17844846
34Fanconi anemia pathway_Homo sapiens_hsa034601.17364056
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15114242
36Other glycan degradation_Homo sapiens_hsa005111.14579562
37Oocyte meiosis_Homo sapiens_hsa041141.10823056
38Basal cell carcinoma_Homo sapiens_hsa052171.10380580
39Acute myeloid leukemia_Homo sapiens_hsa052211.08751982
40Adherens junction_Homo sapiens_hsa045201.08426734
41Thyroid cancer_Homo sapiens_hsa052161.06661013
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06147183
43Bladder cancer_Homo sapiens_hsa052191.02949373
44Osteoclast differentiation_Homo sapiens_hsa043801.02389547
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01965158
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.00773365
47Choline metabolism in cancer_Homo sapiens_hsa052311.00701381
48Epstein-Barr virus infection_Homo sapiens_hsa051690.99665609
49RNA degradation_Homo sapiens_hsa030180.98335040
50Hepatitis C_Homo sapiens_hsa051600.97898838
51Inositol phosphate metabolism_Homo sapiens_hsa005620.97238563
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96548234
53Proteoglycans in cancer_Homo sapiens_hsa052050.94779207
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94066423
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.94005187
56Measles_Homo sapiens_hsa051620.93800379
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93506901
58Long-term potentiation_Homo sapiens_hsa047200.93004038
59Prion diseases_Homo sapiens_hsa050200.92312025
60Influenza A_Homo sapiens_hsa051640.91393271
61B cell receptor signaling pathway_Homo sapiens_hsa046620.91103342
62GnRH signaling pathway_Homo sapiens_hsa049120.88188708
63Herpes simplex infection_Homo sapiens_hsa051680.87908085
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87297215
65Pyrimidine metabolism_Homo sapiens_hsa002400.87026396
66Glioma_Homo sapiens_hsa052140.86841495
67VEGF signaling pathway_Homo sapiens_hsa043700.86631722
68Focal adhesion_Homo sapiens_hsa045100.82748097
69Leishmaniasis_Homo sapiens_hsa051400.82676206
70Non-homologous end-joining_Homo sapiens_hsa034500.82112333
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.80221812
72Hedgehog signaling pathway_Homo sapiens_hsa043400.79663814
73Primary immunodeficiency_Homo sapiens_hsa053400.79348318
74Prostate cancer_Homo sapiens_hsa052150.79089745
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.77658764
76T cell receptor signaling pathway_Homo sapiens_hsa046600.77248618
77Renal cell carcinoma_Homo sapiens_hsa052110.76784821
78Fructose and mannose metabolism_Homo sapiens_hsa000510.76399802
79Alcoholism_Homo sapiens_hsa050340.76263392
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76094280
81Apoptosis_Homo sapiens_hsa042100.75204568
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74612635
83Tight junction_Homo sapiens_hsa045300.74610777
84Estrogen signaling pathway_Homo sapiens_hsa049150.73752364
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73406902
86Pathways in cancer_Homo sapiens_hsa052000.73353396
87Pancreatic cancer_Homo sapiens_hsa052120.73152271
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.71961965
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71903149
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.70697413
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70146737
92Hepatitis B_Homo sapiens_hsa051610.69496882
93Wnt signaling pathway_Homo sapiens_hsa043100.69340975
94Shigellosis_Homo sapiens_hsa051310.68784762
95TGF-beta signaling pathway_Homo sapiens_hsa043500.68303975
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67428171
97Biosynthesis of amino acids_Homo sapiens_hsa012300.63879816
98Sulfur relay system_Homo sapiens_hsa041220.61905693
99Viral myocarditis_Homo sapiens_hsa054160.61716951
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61370047
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61077314
102Endocytosis_Homo sapiens_hsa041440.60686766
103HIF-1 signaling pathway_Homo sapiens_hsa040660.59718959
104AMPK signaling pathway_Homo sapiens_hsa041520.58566922
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.58230690
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57683957
107Chemokine signaling pathway_Homo sapiens_hsa040620.57520205
108Selenocompound metabolism_Homo sapiens_hsa004500.55115411
109TNF signaling pathway_Homo sapiens_hsa046680.53489698
110ECM-receptor interaction_Homo sapiens_hsa045120.53448575
111Melanogenesis_Homo sapiens_hsa049160.53390129
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52483687
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51912870
114FoxO signaling pathway_Homo sapiens_hsa040680.51873215
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51714721
116Type II diabetes mellitus_Homo sapiens_hsa049300.50971548
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.49953882
118MAPK signaling pathway_Homo sapiens_hsa040100.49589603
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49574871
120Dorso-ventral axis formation_Homo sapiens_hsa043200.48325385
121ErbB signaling pathway_Homo sapiens_hsa040120.47607793
122Basal transcription factors_Homo sapiens_hsa030220.47477782
123Insulin signaling pathway_Homo sapiens_hsa049100.47346186
124Insulin resistance_Homo sapiens_hsa049310.46817948
125Platelet activation_Homo sapiens_hsa046110.45638398
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45002780
127Pentose phosphate pathway_Homo sapiens_hsa000300.43767337
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43672647
129Prolactin signaling pathway_Homo sapiens_hsa049170.43067396
130Toxoplasmosis_Homo sapiens_hsa051450.42669613
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.40627119
132Vitamin B6 metabolism_Homo sapiens_hsa007500.38822267
133Amoebiasis_Homo sapiens_hsa051460.37278028
134Melanoma_Homo sapiens_hsa052180.36542127

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »