UBTFL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine metabolic process (GO:0006586)5.30025511
2thalamus development (GO:0021794)5.11416657
3tryptophan metabolic process (GO:0006568)4.48907684
4amine catabolic process (GO:0009310)4.28332290
5cellular biogenic amine catabolic process (GO:0042402)4.28332290
6regulation of receptor binding (GO:1900120)4.17270655
7indole-containing compound metabolic process (GO:0042430)3.99055324
8regulation of G0 to G1 transition (GO:0070316)3.99032318
9protein neddylation (GO:0045116)3.95675654
10response to lipoprotein particle (GO:0055094)3.90969647
11regulation of glucokinase activity (GO:0033131)3.79771255
12regulation of hexokinase activity (GO:1903299)3.79771255
13negative regulation of telomerase activity (GO:0051974)3.75736002
14negative regulation of heart rate (GO:0010459)3.74616455
15regulation of sequestering of triglyceride (GO:0010889)3.70051282
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60868178
17serotonin metabolic process (GO:0042428)3.60596117
18tryptophan catabolic process (GO:0006569)3.56971518
19indole-containing compound catabolic process (GO:0042436)3.56971518
20indolalkylamine catabolic process (GO:0046218)3.56971518
21positive regulation of oligodendrocyte differentiation (GO:0048714)3.48520587
22regulation of telomerase activity (GO:0051972)3.48132631
23histone H4-K12 acetylation (GO:0043983)3.44753911
24somite development (GO:0061053)3.43883650
25ADP metabolic process (GO:0046031)3.40119309
26alkaloid metabolic process (GO:0009820)3.39524539
27positive regulation of cAMP-mediated signaling (GO:0043950)3.37284438
28primary amino compound metabolic process (GO:1901160)3.35195793
29transmission of nerve impulse (GO:0019226)3.28042524
30peptidyl-threonine dephosphorylation (GO:0035970)3.22470823
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21343433
32response to caffeine (GO:0031000)3.13611204
33axonemal dynein complex assembly (GO:0070286)3.11931493
34dendritic spine morphogenesis (GO:0060997)3.09044572
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09002431
36ATP synthesis coupled proton transport (GO:0015986)3.09002431
37negative regulation of acute inflammatory response (GO:0002674)3.08785076
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.07097918
39NADH dehydrogenase complex assembly (GO:0010257)3.07097918
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07097918
41spinal cord development (GO:0021510)3.05505701
42cellular biogenic amine biosynthetic process (GO:0042401)3.03631868
43sequestering of actin monomers (GO:0042989)3.01322217
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00639088
45negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.00314529
46kynurenine metabolic process (GO:0070189)2.98645457
47cell differentiation in hindbrain (GO:0021533)2.96758972
48dopamine transport (GO:0015872)2.93786833
49serine family amino acid catabolic process (GO:0009071)2.93156913
50cell proliferation in forebrain (GO:0021846)2.91902192
51behavioral response to nicotine (GO:0035095)2.90407954
52hindbrain development (GO:0030902)2.89603933
53amine biosynthetic process (GO:0009309)2.87985105
54positive regulation of fatty acid oxidation (GO:0046321)2.87460934
55cornea development in camera-type eye (GO:0061303)2.86625614
56negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.85996577
57sympathetic nervous system development (GO:0048485)2.83859504
58positive regulation of glomerulus development (GO:0090193)2.81942236
59neuronal action potential propagation (GO:0019227)2.80800610
60pharyngeal system development (GO:0060037)2.80075908
61negative regulation of response to food (GO:0032096)2.77020221
62negative regulation of appetite (GO:0032099)2.77020221
63regulation of memory T cell differentiation (GO:0043380)2.75623599
64nitric oxide mediated signal transduction (GO:0007263)2.75618383
65lateral sprouting from an epithelium (GO:0060601)2.75514126
66regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73194055
67white fat cell differentiation (GO:0050872)2.71266206
68cardiolipin metabolic process (GO:0032048)2.71193048
69regulation of collateral sprouting (GO:0048670)2.67170431
70negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.66494814
71neuronal action potential (GO:0019228)2.65314238
72retinal ganglion cell axon guidance (GO:0031290)2.63208651
73glycerophospholipid catabolic process (GO:0046475)2.61245263
74branching involved in labyrinthine layer morphogenesis (GO:0060670)2.60908178
75positive regulation of gastrulation (GO:2000543)2.59363544
76parturition (GO:0007567)2.57996869
77glycerol metabolic process (GO:0006071)2.57845187
78ether metabolic process (GO:0018904)2.57634455
79spinal cord motor neuron differentiation (GO:0021522)2.56095681
80regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.55569411
81pyrimidine nucleobase catabolic process (GO:0006208)2.54441427
82cellular response to lithium ion (GO:0071285)2.52126693
83negative regulation of axon guidance (GO:1902668)2.51140860
84exogenous drug catabolic process (GO:0042738)2.50932211
85presynaptic membrane assembly (GO:0097105)2.50480617
86negative regulation of calcium ion transport into cytosol (GO:0010523)2.49216806
87negative chemotaxis (GO:0050919)2.47527073
88negative regulation of astrocyte differentiation (GO:0048712)2.47317837
89negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.46809412
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.46715486
91adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.42982580
92multicellular organism reproduction (GO:0032504)2.42729125
93ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.42078694
94catecholamine transport (GO:0051937)2.41669526
95positive regulation of steroid hormone secretion (GO:2000833)2.41625548
96ovulation cycle (GO:0042698)2.41317789
97positive regulation of potassium ion transmembrane transport (GO:1901381)2.40674146
98cell differentiation in spinal cord (GO:0021515)2.40290973
99membrane depolarization during action potential (GO:0086010)2.40266912
100cochlea development (GO:0090102)2.37476429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.54173879
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.69903207
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90958378
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74764925
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.68186840
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.67940807
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.56359849
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56132829
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.56056165
10ZNF274_21170338_ChIP-Seq_K562_Hela2.53572045
11IRF1_19129219_ChIP-ChIP_H3396_Human2.47546528
12GBX2_23144817_ChIP-Seq_PC3_Human2.35211470
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33344860
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21006424
15IGF1R_20145208_ChIP-Seq_DFB_Human2.20511328
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.17014849
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15514345
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.14895040
19REST_21632747_ChIP-Seq_MESCs_Mouse2.14163624
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11254134
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11254134
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03613948
23RNF2_27304074_Chip-Seq_NSC_Mouse2.03431718
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01061137
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00006251
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97624326
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93446056
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91565708
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89006683
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87305439
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84981132
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.84981132
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80020417
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.78689509
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74209748
36DROSHA_22980978_ChIP-Seq_HELA_Human1.73828691
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65630241
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62770506
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.62687556
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61365407
41VDR_22108803_ChIP-Seq_LS180_Human1.53217365
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49038061
43SMAD4_21799915_ChIP-Seq_A2780_Human1.37841752
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33163852
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33012883
46TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29017778
47TAF15_26573619_Chip-Seq_HEK293_Human1.25233232
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.22355426
49AR_25329375_ChIP-Seq_VCAP_Human1.19753132
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.16277196
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14757710
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13652260
53P300_19829295_ChIP-Seq_ESCs_Human1.13340394
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11705367
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10843485
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08268297
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07051841
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05631353
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04079731
60ER_23166858_ChIP-Seq_MCF-7_Human1.02359474
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.01711028
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01291029
63GATA3_21878914_ChIP-Seq_MCF-7_Human0.99807454
64AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99573619
65ARNT_22903824_ChIP-Seq_MCF-7_Human0.98845906
66FUS_26573619_Chip-Seq_HEK293_Human0.97519477
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97006712
68TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96708558
69TCF4_23295773_ChIP-Seq_U87_Human0.96007824
70TAL1_26923725_Chip-Seq_HPCs_Mouse0.95945969
71STAT3_23295773_ChIP-Seq_U87_Human0.95349351
72BCAT_22108803_ChIP-Seq_LS180_Human0.95056463
73WDR5_24793694_ChIP-Seq_LNCAP_Human0.94584199
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93559360
75SMAD4_21741376_ChIP-Seq_HESCs_Human0.92640069
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92593710
77JUN_21703547_ChIP-Seq_K562_Human0.91337771
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91238821
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90844370
80RUNX2_22187159_ChIP-Seq_PCA_Human0.90399844
81MYC_18940864_ChIP-ChIP_HL60_Human0.89748188
82EGR1_19032775_ChIP-ChIP_M12_Human0.89331977
83NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89330055
84AHR_22903824_ChIP-Seq_MCF-7_Human0.89013913
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88908108
86AR_21572438_ChIP-Seq_LNCaP_Human0.88802966
87GATA1_26923725_Chip-Seq_HPCs_Mouse0.88771414
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87646564
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87417126
90TP53_22573176_ChIP-Seq_HFKS_Human0.86853126
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86709175
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.86405454
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84838399
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.84355508
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83423402
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82849780
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82827681
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.82717104
99ERG_20517297_ChIP-Seq_VCAP_Human0.82504172
100EWS_26573619_Chip-Seq_HEK293_Human0.81780087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.32114488
2MP0000569_abnormal_digit_pigmentation3.82411803
3MP0003724_increased_susceptibility_to3.70449308
4MP0002138_abnormal_hepatobiliary_system2.79367002
5MP0003122_maternal_imprinting2.67623145
6MP0004859_abnormal_synaptic_plasticity2.42272357
7MP0005645_abnormal_hypothalamus_physiol2.20969749
8MP0004858_abnormal_nervous_system2.19646706
9MP0002102_abnormal_ear_morphology2.09649793
10MP0000372_irregular_coat_pigmentation2.09084122
11MP0001440_abnormal_grooming_behavior2.01314330
12MP0001968_abnormal_touch/_nociception1.99051583
13MP0003121_genomic_imprinting1.90001290
14MP0002733_abnormal_thermal_nociception1.88927147
15MP0005646_abnormal_pituitary_gland1.87677648
16MP0006292_abnormal_olfactory_placode1.86729568
17MP0002653_abnormal_ependyma_morphology1.86445836
18MP0005085_abnormal_gallbladder_physiolo1.85275413
19MP0008872_abnormal_physiological_respon1.80401211
20MP0009745_abnormal_behavioral_response1.71220651
21MP0004142_abnormal_muscle_tone1.70007356
22MP0002272_abnormal_nervous_system1.69057719
23MP0004130_abnormal_muscle_cell1.68671903
24MP0000013_abnormal_adipose_tissue1.67920215
25MP0009053_abnormal_anal_canal1.67673599
26MP0002736_abnormal_nociception_after1.66136173
27MP0003635_abnormal_synaptic_transmissio1.65925579
28MP0008004_abnormal_stomach_pH1.63672559
29MP0008875_abnormal_xenobiotic_pharmacok1.62165345
30MP0002184_abnormal_innervation1.60488188
31MP0003787_abnormal_imprinting1.60386532
32MP0002064_seizures1.56647773
33MP0000778_abnormal_nervous_system1.55579747
34MP0000537_abnormal_urethra_morphology1.51122907
35MP0005551_abnormal_eye_electrophysiolog1.48524880
36MP0008569_lethality_at_weaning1.48483308
37MP0001970_abnormal_pain_threshold1.44869821
38MP0001485_abnormal_pinna_reflex1.42980663
39MP0004133_heterotaxia1.41488672
40MP0002160_abnormal_reproductive_system1.38906589
41MP0002572_abnormal_emotion/affect_behav1.38684837
42MP0003938_abnormal_ear_development1.36258603
43MP0003252_abnormal_bile_duct1.35785127
44MP0005174_abnormal_tail_pigmentation1.35316150
45MP0006276_abnormal_autonomic_nervous1.31854619
46MP0003123_paternal_imprinting1.31147854
47MP0003119_abnormal_digestive_system1.29637781
48MP0009765_abnormal_xenobiotic_induced1.29017619
49MP0002876_abnormal_thyroid_physiology1.28148575
50MP0008877_abnormal_DNA_methylation1.27349547
51MP0000049_abnormal_middle_ear1.24938718
52MP0002063_abnormal_learning/memory/cond1.24038382
53MP0003011_delayed_dark_adaptation1.23779404
54MP0005464_abnormal_platelet_physiology1.21611033
55MP0009379_abnormal_foot_pigmentation1.19462534
56MP0002751_abnormal_autonomic_nervous1.18701652
57MP0003890_abnormal_embryonic-extraembry1.18534093
58MP0002557_abnormal_social/conspecific_i1.17877769
59MP0001905_abnormal_dopamine_level1.15114373
60MP0002277_abnormal_respiratory_mucosa1.13768007
61MP0000534_abnormal_ureter_morphology1.13085161
62MP0005367_renal/urinary_system_phenotyp1.12664614
63MP0000516_abnormal_urinary_system1.12664614
64MP0003718_maternal_effect1.12463419
65MP0000230_abnormal_systemic_arterial1.11465032
66MP0003879_abnormal_hair_cell1.10252370
67MP0005379_endocrine/exocrine_gland_phen1.08844147
68MP0005365_abnormal_bile_salt1.08793437
69MP0002067_abnormal_sensory_capabilities1.08786531
70MP0005167_abnormal_blood-brain_barrier1.08420769
71MP0002752_abnormal_somatic_nervous1.08418546
72MP0005195_abnormal_posterior_eye1.06988125
73MP0000955_abnormal_spinal_cord1.06330883
74MP0005423_abnormal_somatic_nervous1.05851957
75MP0001963_abnormal_hearing_physiology1.04163905
76MP0009046_muscle_twitch1.02330812
77MP0000015_abnormal_ear_pigmentation0.98722683
78MP0001664_abnormal_digestion0.98032018
79MP0005389_reproductive_system_phenotype0.97165839
80MP0002132_abnormal_respiratory_system0.96985168
81MP0000026_abnormal_inner_ear0.95137682
82MP0002882_abnormal_neuron_morphology0.94779190
83MP0001486_abnormal_startle_reflex0.94471785
84MP0001661_extended_life_span0.92735951
85MP0003646_muscle_fatigue0.91188277
86MP0003638_abnormal_response/metabolism_0.88849035
87MP0004145_abnormal_muscle_electrophysio0.88682454
88MP0000631_abnormal_neuroendocrine_gland0.88256762
89MP0003329_amyloid_beta_deposits0.88027272
90MP0003942_abnormal_urinary_system0.87341169
91MP0005083_abnormal_biliary_tract0.87302206
92MP0002734_abnormal_mechanical_nocicepti0.86791964
93MP0006072_abnormal_retinal_apoptosis0.85187586
94MP0004043_abnormal_pH_regulation0.83252280
95MP0003315_abnormal_perineum_morphology0.82809880
96MP0002735_abnormal_chemical_nociception0.76656484
97MP0003283_abnormal_digestive_organ0.76376715
98MP0003937_abnormal_limbs/digits/tail_de0.75417177
99MP0004885_abnormal_endolymph0.75381659
100MP0002837_dystrophic_cardiac_calcinosis0.74341530

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)5.46546370
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.46546370
3Stenosis of the external auditory canal (HP:0000402)4.98848418
4Abnormality of the 1st metacarpal (HP:0010009)4.84229144
5Oligomenorrhea (HP:0000876)3.94543701
6Short phalanx of the thumb (HP:0009660)3.86560264
7Abnormal ciliary motility (HP:0012262)3.68760955
8Focal motor seizures (HP:0011153)3.53536768
9Myokymia (HP:0002411)3.52495627
10Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.32637745
11Agitation (HP:0000713)3.27339051
12Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.22247659
13Acute necrotizing encephalopathy (HP:0006965)3.21060134
14Pendular nystagmus (HP:0012043)3.10019625
15Abnormality of the phalanges of the 5th finger (HP:0004213)3.08764401
16Congenital stationary night blindness (HP:0007642)2.96825427
17Abnormal mitochondria in muscle tissue (HP:0008316)2.95496827
18Recurrent corneal erosions (HP:0000495)2.85494369
19Fused cervical vertebrae (HP:0002949)2.85280841
20Short hallux (HP:0010109)2.80799529
21Abnormality of the costochondral junction (HP:0000919)2.74564819
22Aplasia/Hypoplasia of the hallux (HP:0008362)2.72316731
23Abnormal respiratory motile cilium physiology (HP:0012261)2.71884137
24Synostosis of carpal bones (HP:0005048)2.71043280
25Focal seizures (HP:0007359)2.64307896
26Absent thumb (HP:0009777)2.60606575
27Progressive macrocephaly (HP:0004481)2.60189839
28Febrile seizures (HP:0002373)2.59477311
29Nephronophthisis (HP:0000090)2.59477092
30Increased corneal curvature (HP:0100692)2.53274992
31Keratoconus (HP:0000563)2.53274992
32Acute encephalopathy (HP:0006846)2.45695947
33Abnormality of the labia minora (HP:0012880)2.42979565
34Hematochezia (HP:0002573)2.42753929
35Polyphagia (HP:0002591)2.42381788
36Optic disc pallor (HP:0000543)2.39473946
37Hypothermia (HP:0002045)2.39461472
38Conjugated hyperbilirubinemia (HP:0002908)2.35510017
39Conical tooth (HP:0000698)2.34791644
40Maternal diabetes (HP:0009800)2.32808123
41Abnormality of the renal collecting system (HP:0004742)2.31746699
42Hyperventilation (HP:0002883)2.29673420
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28813369
44Symphalangism affecting the phalanges of the hand (HP:0009773)2.25509063
45Abnormality of DNA repair (HP:0003254)2.25221070
46Decreased subcutaneous fat (HP:0001002)2.22778486
47Tented upper lip vermilion (HP:0010804)2.22277937
48Abnormal rod and cone electroretinograms (HP:0008323)2.19395862
49Esotropia (HP:0000565)2.18017752
50Attenuation of retinal blood vessels (HP:0007843)2.17664528
51Hypoalphalipoproteinemia (HP:0003233)2.17334238
52Visual hallucinations (HP:0002367)2.16795196
53Abnormal drinking behavior (HP:0030082)2.15708388
54Polydipsia (HP:0001959)2.15708388
55Chorioretinal atrophy (HP:0000533)2.14529926
56Short humerus (HP:0005792)2.14459626
57Abnormality of midbrain morphology (HP:0002418)2.13752159
58Molar tooth sign on MRI (HP:0002419)2.13752159
59Limb dystonia (HP:0002451)2.04184078
60Abnormality of cells of the erythroid lineage (HP:0012130)2.04001038
61Bony spicule pigmentary retinopathy (HP:0007737)2.03436388
62Status epilepticus (HP:0002133)2.03407366
63Pancreatic cysts (HP:0001737)2.03177203
64Tubulointerstitial fibrosis (HP:0005576)2.02482109
65Abnormality of the renal medulla (HP:0100957)2.01248456
66Ectopic kidney (HP:0000086)2.00527021
67Abnormality of the renal cortex (HP:0011035)2.00091326
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99544557
69Abnormality of the nasal septum (HP:0000419)1.98648039
70Abnormality of the proximal phalanges of the hand (HP:0009834)1.98050777
71Morphological abnormality of the middle ear (HP:0008609)1.97876196
72Hypoplasia of the ulna (HP:0003022)1.97000019
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96918914
74Abnormality of alanine metabolism (HP:0010916)1.96918914
75Hyperalaninemia (HP:0003348)1.96918914
76Carpal synostosis (HP:0009702)1.95709266
77Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95500001
78Medial flaring of the eyebrow (HP:0010747)1.95272460
79Short thumb (HP:0009778)1.94661347
80Petechiae (HP:0000967)1.94192036
81Mitochondrial inheritance (HP:0001427)1.92120480
82True hermaphroditism (HP:0010459)1.91534919
83Increased CSF lactate (HP:0002490)1.90651998
84Reticulocytopenia (HP:0001896)1.89963084
85Tubular atrophy (HP:0000092)1.87492914
86Osteomalacia (HP:0002749)1.85885057
87Pancreatic fibrosis (HP:0100732)1.84441829
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.84353596
89Toxemia of pregnancy (HP:0100603)1.83200772
90Pachygyria (HP:0001302)1.83138086
91Progressive cerebellar ataxia (HP:0002073)1.81275146
92Vertebral fusion (HP:0002948)1.79867781
93Supernumerary spleens (HP:0009799)1.79203525
94Synostosis involving bones of the hand (HP:0004278)1.78671357
95Aplasia/hypoplasia of the humerus (HP:0006507)1.78437751
96Pallor (HP:0000980)1.75904110
97Insulin-resistant diabetes mellitus (HP:0000831)1.75818059
98Abnormal eating behavior (HP:0100738)1.75273236
99Chronic obstructive pulmonary disease (HP:0006510)1.75267478
100Obstructive lung disease (HP:0006536)1.75267478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.73560543
2GRK13.00337774
3BRAF2.76857130
4NTRK32.66882681
5MARK12.64266216
6ZAK2.32796374
7FRK2.31528834
8TLK12.13005105
9ARAF2.06910137
10NUAK12.05183308
11PHKG11.91243586
12PHKG21.91243586
13PIM21.90196090
14MAP2K21.85843497
15PLK21.84463251
16EPHB11.83775990
17MAPK131.81844224
18TEC1.75856095
19MAP3K101.73023752
20TRIM281.66195953
21DYRK21.63818587
22PTK2B1.61797693
23GRK71.60145317
24GRK51.57600267
25MAP2K71.54347835
26FLT31.48140124
27DYRK31.40926347
28MAP2K11.33380089
29RPS6KA21.31823151
30PKN11.27681544
31DYRK1B1.21461358
32GRK61.20065099
33PDK21.11953802
34ADRBK11.09989616
35CASK1.06439447
36LMTK21.05148132
37ERBB31.03918881
38WNK41.03863857
39MAP3K91.01981694
40PRKCG1.01278467
41DYRK1A1.01055378
42NTRK20.99501190
43CDK30.99290377
44RAF10.99171612
45NME10.92279240
46PRKCQ0.91910685
47CDK90.91550669
48SGK20.91231111
49RPS6KA50.90739217
50RPS6KA60.90043927
51ITK0.88314531
52MAPK150.88003599
53PRKCE0.87400972
54DMPK0.87323168
55TAOK30.86234542
56KIT0.79483492
57SYK0.77344404
58CAMK10.75331366
59VRK10.74636910
60PRKACA0.72193127
61SGK4940.71905041
62SGK2230.71905041
63MAP3K40.70546557
64MUSK0.70305955
65RPS6KL10.68546586
66RPS6KC10.68546586
67RPS6KA40.68419996
68PIM10.66962583
69EIF2AK10.66246564
70PAK30.66023305
71CAMK2A0.65016666
72CDK50.63515409
73MINK10.62957065
74INSRR0.61834445
75VRK20.61099890
76KDR0.60956786
77CAMKK20.57677882
78ERBB20.56967686
79ABL20.54573699
80MATK0.53672395
81MAP2K60.53354766
82SGK30.51643896
83CAMK40.51209341
84PRKCA0.49709622
85PNCK0.49432696
86MAPK30.47113983
87PRKCI0.46351906
88CSNK1G20.42996162
89CAMK2B0.41908341
90FYN0.40302262
91UHMK10.39783891
92ALK0.39712530
93PRKACG0.38404160
94LYN0.37468046
95CSNK1A10.37031969
96FES0.36409437
97CSNK1D0.36288246
98PRKCB0.36144738
99NTRK10.35369944
100CSK0.35235924

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.05497091
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.64281393
3Tryptophan metabolism_Homo sapiens_hsa003802.53221971
4Phototransduction_Homo sapiens_hsa047442.44506743
5Oxidative phosphorylation_Homo sapiens_hsa001902.44162347
6Caffeine metabolism_Homo sapiens_hsa002322.41237052
7Linoleic acid metabolism_Homo sapiens_hsa005912.40839237
8Nitrogen metabolism_Homo sapiens_hsa009102.16230477
9Nicotine addiction_Homo sapiens_hsa050332.12880525
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.05827319
11Cardiac muscle contraction_Homo sapiens_hsa042602.04812678
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04599688
13Alzheimers disease_Homo sapiens_hsa050101.98943477
14Parkinsons disease_Homo sapiens_hsa050121.97413116
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91014423
16Long-term depression_Homo sapiens_hsa047301.85519633
17Serotonergic synapse_Homo sapiens_hsa047261.80577556
18Collecting duct acid secretion_Homo sapiens_hsa049661.80510790
19Ether lipid metabolism_Homo sapiens_hsa005651.76522495
20Morphine addiction_Homo sapiens_hsa050321.65290199
21Olfactory transduction_Homo sapiens_hsa047401.64329599
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63505935
23Circadian entrainment_Homo sapiens_hsa047131.60546207
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58653993
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.54417536
26Sulfur metabolism_Homo sapiens_hsa009201.50801919
27Salivary secretion_Homo sapiens_hsa049701.41365315
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38031506
29Retinol metabolism_Homo sapiens_hsa008301.37329509
30Butanoate metabolism_Homo sapiens_hsa006501.36020965
31Gap junction_Homo sapiens_hsa045401.30499083
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29845050
33Huntingtons disease_Homo sapiens_hsa050161.26297225
34Synaptic vesicle cycle_Homo sapiens_hsa047211.25795403
35Chemical carcinogenesis_Homo sapiens_hsa052041.22139287
36Taste transduction_Homo sapiens_hsa047421.20544071
37Histidine metabolism_Homo sapiens_hsa003401.17781767
38Arachidonic acid metabolism_Homo sapiens_hsa005901.16384906
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14386190
40beta-Alanine metabolism_Homo sapiens_hsa004101.14290959
41Starch and sucrose metabolism_Homo sapiens_hsa005001.13352694
42ABC transporters_Homo sapiens_hsa020101.11567253
43GABAergic synapse_Homo sapiens_hsa047271.10494882
44Glutamatergic synapse_Homo sapiens_hsa047241.09903175
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08144949
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03958685
47Peroxisome_Homo sapiens_hsa041460.99697131
48Arginine and proline metabolism_Homo sapiens_hsa003300.97850631
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.97602617
50Insulin secretion_Homo sapiens_hsa049110.94081024
51Basal cell carcinoma_Homo sapiens_hsa052170.92984850
52Glycerolipid metabolism_Homo sapiens_hsa005610.85895256
53Axon guidance_Homo sapiens_hsa043600.83931527
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82818423
55Ovarian steroidogenesis_Homo sapiens_hsa049130.78419159
56Cholinergic synapse_Homo sapiens_hsa047250.75163177
57Fat digestion and absorption_Homo sapiens_hsa049750.74542388
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73038271
59Oxytocin signaling pathway_Homo sapiens_hsa049210.72744629
60Renin secretion_Homo sapiens_hsa049240.71364294
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69145334
62Pancreatic secretion_Homo sapiens_hsa049720.68706958
63Dopaminergic synapse_Homo sapiens_hsa047280.67878558
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62924481
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62232607
66Renin-angiotensin system_Homo sapiens_hsa046140.59903765
67Asthma_Homo sapiens_hsa053100.59547303
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.58492782
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.57127864
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55228523
71Steroid biosynthesis_Homo sapiens_hsa001000.55142311
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54990877
73Long-term potentiation_Homo sapiens_hsa047200.54887755
74Ribosome_Homo sapiens_hsa030100.54672887
75Phagosome_Homo sapiens_hsa041450.54189669
76Hematopoietic cell lineage_Homo sapiens_hsa046400.53579461
77Gastric acid secretion_Homo sapiens_hsa049710.52259985
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51171694
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50965217
80MAPK signaling pathway_Homo sapiens_hsa040100.50164448
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49942455
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48371941
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48211580
84Calcium signaling pathway_Homo sapiens_hsa040200.48133903
85Platelet activation_Homo sapiens_hsa046110.48107957
86Fatty acid degradation_Homo sapiens_hsa000710.47734221
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.47295101
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46772046
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46283132
90Ras signaling pathway_Homo sapiens_hsa040140.46234271
91Bile secretion_Homo sapiens_hsa049760.45484009
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45152526
93Hedgehog signaling pathway_Homo sapiens_hsa043400.42991043
94PPAR signaling pathway_Homo sapiens_hsa033200.42004316
95Cocaine addiction_Homo sapiens_hsa050300.41439253
96Alcoholism_Homo sapiens_hsa050340.40440242
97Thyroid cancer_Homo sapiens_hsa052160.39446567
98Primary immunodeficiency_Homo sapiens_hsa053400.36122985
99cAMP signaling pathway_Homo sapiens_hsa040240.35861536
100Rheumatoid arthritis_Homo sapiens_hsa053230.34652519

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